2010 Annual Report - U-M Kellogg Eye Center by U-M Kellogg Eye Center

UNIVERSITY OF MICHIGAN W.K. KELLOGG EYE CENTER 2010 ANNUAL REPORT

“

As much as we delight in the design of the newest medical

facility on campus, the Brehm Tower, its power lies inside.

It is the people and the programs that will make a

difference in the lives of our patients.

”

Dear Friends, It is a magnificent building. The light filters into our reception areas and meeting rooms. The clinics, operating rooms, and laboratories are spacious and filled with the most advanced equipment. Art graces every wall and, outside, a beautiful garden provides visitors with a restful place for reflection. As much as we delight in the design of the newest medical facility on campus, the Brehm Tower, its power lies inside. It is the people and the programs that will make a difference in the lives of our patients. And so this year’s Annual Report shares both the celebration and the great promise of the expanded W.K. Kellogg Eye Center. Dedication photos feature the people at the heart of our endeavor: friends, alumni, patients, donors, faculty, and staff who made this building and the Department’s bright future possible. You’ll see leaders of the University and Health System, as well as internationally known leaders in ophthalmology, many of whom traveled the globe to join us for a special symposium to share their clinical experiences. The theme that echoed through each event, Dedicated to Discovery, is our blueprint for the future. We begin by welcoming 13 new faculty members. In the fall, a team of scientists and clinicians joined the Department, bringing with them an innovative research program targeting diabetic eye disease. These faculty will work closely with other colleagues who study diabetic retinopathy and retinal regeneration. They will also collaborate with Brehm Center scientists who seek a cure for diabetes and with scientists across the medical campus who study the neurological and renal complications of the disease. These powerful collaborations are sure to yield new treatments for our patients suffering from the complications of diabetes. Another faculty recruit has joined the Department to establish a comprehensive ocular oncology service. This new service draws both on our faculty with many years’ experience in managing ocular tumors, as well as oncologists in Michigan’s Comprehensive Cancer Center. With this growing multidisciplinary service, we can help many more patients across the country who need the specialty care they will receive in our new clinic. There is much more. Our residents and fellows will benefit from training in this high-tech facility. With added faculty in pediatric ophthalmology, we can provide advanced treatment to many more children who suffer from eye disease. A new Low Vision Skills Center will help individuals with impaired vision maintain their independence. And all of our patients will enjoy comfortable and spacious surroundings as they visit some of the finest ophthalmologists in the nation. We are more optimistic than ever that the W.K. Kellogg Eye Center—thanks to the talented people within—will lead the next breakthroughs in vision science. With deep gratitude to our many friends and supporters, we remain dedicated to our patients and to the discoveries that will give them the best possible vision, allowing them to lead rich and independent lives.

Paul R. Lichter, M.D. F. Bruce Fralick Professor and Chair University of Michigan Department of Ophthalmology and Visual Sciences Director, W.K. Kellogg Eye Center

New building sets stage for “hope and possibility” as growing faculty pursues more effective treatments and cures for eye disease A crowd filled the seats and lined the walls of a sprawling tent set up to celebrate the dedication of the Brehm Tower at the W.K. Kellogg Eye Center in April. From the podium behind a row of colorful tulips, University President Mary Sue Coleman reminded everyone why they were there. She quoted W.K. Kellogg, who, blinded by glaucoma late in life, once said, “I would give all my money just to see the sun and green grass again.” “It is that simple desire to see the world,” President Coleman said, “that drives our students, our faculty and staff, and the generous donors who support the constant quest for answers at the Kellogg Eye Center.” Leading ophthalmologists from around the world joined University leaders and the Kellogg Eye Center’s friends, faculty, and staff as President Coleman, Kellogg Eye Center Director Paul R. Lichter, M.D., and Bill and Dee Brehm cut the ceremonial ribbon. The Brehms have launched a diabetes research center which makes its home in the new building. 2

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Dedication events included the ceremony, a reception and tours of the new building, a dinner for ophthalmologists from across the state and region, an Ann Arbor Symphony Orchestra concert, and a dedication dinner honoring supporters of the Eye Center’s expansion campaign. Dr. Lichter expressed his thanks to guests attending the celebration. “You have given us so much support,” he said, “and we will deliver for you in the years ahead.” Krista Anderson, Ph.D., spoke at the dedication dinner, recalling her family’s three generations of vision care at the University of Michigan and the “amazing advances in medicine” they’ve experienced. “Tonight is a time when I can smile and share the gratitude in my heart for Kellogg and the top-notch professionals who work here,” Dr. Anderson said. “To me, Kellogg has always been and will always be a place of hope and possibility.”

Dedicated to Discovery

More than 700 guests gathered to dedicate and celebrate the new W.K. Kellogg Eye Center.

President Mary Sue Coleman spoke of her hopes for research to cure diabetes and eye disease.

Dorrit Jensen and Larry Miller just before the ceremony begins.

Guests proceed to the Dedication ceremony alongside banners created for the event. Dedicated to Discovery

Students from the U-M School of Music perform â&#x20AC;&#x153;Our Michigan,â&#x20AC;? written by Bill Brehm.

Paul Sieving, M.D., Ph.D., Director of the National Eye Institute.

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Congressman John D. Dingell with his wife, Debbie, and the Reverend C. Parker Wright.

President Mary Sue Coleman, Dee and Bill Brehm, and Paul Lichter, M.D., cut the ceremonial ribbon. Keynote speaker Gail Wilensky, Ph.D., an economist and senior fellow at Project HOPE, stands at left.

Dean James Woolliscroft, Douglas Strong, M.B.A., CEO, U-M Hospitals and Health Centers, and Department Chair Paul Lichter, M.D., at the Dedication reception.

Jim Thompson and Mary Ann Brandt, friends of the Kellogg Eye Center.

Dedicated to Discovery

Brian Campbell, Martha Bloom, and Allen Lichter, M.D. Dr. Lichter served as Dean of the Medical School when the expansion project was initiated.

Krista Anderson, Ph.D., with her daughter, Zoe, and father, Bruce Oliver, described advances in eye care that helped her family. 6

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James McHale, Chief of Staff and Senior Vice President for Programs, W.K. Kellogg Foundation, spoke at the Dedication dinner.

Visionaries:

Campaign Finale Dinner Friends of the Kellogg Eye Center gave more than $36 million to expand our facility and our research programs during a 10-year fund-raising campaign that culminated with the dedication of the new building. Several hundred of those supporters toasted one another and took a celebratory look at the future at a dinner in the atrium of the Biomedical Science Research Building. Remarks were given by contributor Leonard G. Miller and James E. McHale, Senior Vice President for Programs at the W.K. Kellogg Foundation. Bruce Oliver and Krista Anderson, Ph.D., also took the stage to share their story of overcoming their familyâ&#x20AC;&#x2122;s vision difficulties. Alumnus W. Scott Wilkinson, M.D., ended the evening with a song he wrote about philanthropy and working together to make the world a better place. His theme: Planting shade trees under which you know youâ&#x20AC;&#x2122;ll never sit.

Dedicated to Discovery

Dee and Bill Brehm are recognized for their foresight and generosity in creating the Brehm Center for Diabetes Research, which is housed in the building named for them.

Carol Bradford, M.D., Chair of Otolaryngology. 8

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Kristen Del Monte and Elizabeth Stieg, Executive Director of the Carls Foundation, at the dinner celebrating friends and donors of the Eye Center.

Larry Gerbens, M.D., Mary Gerbens, Connie Benz, and Steven Benz, M.D. Dr. Gerbens and Dr. Benz are members of the Alumni Advisory Board.

Thomas G. Varbedian, M.D., and Darlene Eagle.

Helmut Stern, longtime friend of the Department, with Michael Staebler.

Dedicated to Discovery

Ophthalmologists came from around the world to speak at our Dedication symposium. Seated (l to r): Joan Oâ&#x20AC;&#x2122;Brien, M.D., Jialiang Zhao, M.D., Paul Lichter, M.D., Alfred Sommer, M.D., M.H.S., Paul Sieving, M.D., Ph.D., Anthony Adamis, M.D. Standing (l to r): Eduardo Alfonso, M.D., Gary Abrams, M.D., Anthony Moore, M.D., Hugh Taylor, A.C., M.D., Paul Lee, M.D., J.D., Rubens Belfort, Jr., M.D., Ph.D., Joan Miller, M.D., Peter Wiedemann, M.D., Robert Folberg, M.D., Paul Edwards, M.D., Jacob Peâ&#x20AC;&#x2122;er, M.D., David Kaufman, D.O., David Wilson, M.D.

Alfred Sommer, M.D., M.H.S., gave the Fralick Lecture and Joan Miller, M.D., was a guest lecturer at Spring Conference. 10

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Michael Mesaros, M.D., and Linferd Linabery, M.D., were among the ophthalmologists attending the symposium.

Leaders in the Field: Scientific Symposium

The Kellogg Eye Center welcomed 20 leading ophthalmologists from across the nation and around the world to Ann Arbor for a scientific symposium marking the historical occasion of our expansion. Among the distinguished guest faculty were the director of the National Eye Institute, deans and department chairs, and at least one entrepreneur turned corporate officer. The speakers drew on their experience to provide insight into both common and unexpected clinical problems. Alfred Sommer, M.D., M.H.S., Dean Emeritus and Professor of Epidemiology, Ophthalmology, and International Health at Johns Hopkins University’s Bloomberg School of Public Health, gave the F. Bruce Fralick Lecture on his work to improve international mortality rates and health through the study of vitamin A deficiencies. “I don’t think I’ve ever been to a meeting where so many luminaries in the field have been together in one spot,” commented Michael SmithWheelock, M.D., Assistant Professor of Ophthalmology and Visual Sciences, during the symposium. “It is incredibly exciting and wonderful to be a part of it.” Dedicated to Discovery

Reaching Out: Community Events

To honor the collaborative spirit of vision care in Michigan, we invited ophthalmologists from across the state and region to join us for a special dinner. Held at the University of Michigan Museum of Art, the event offered an opportunity to thank our partners and commemorate the dedication of a building that will benefit all ophthalmologists and their patients. To celebrate with and thank the broader community for the important role it plays in the success of our programs, the Kellogg Eye Center also sponsored a performance of the Ann Arbor Symphony Orchestra. Called â&#x20AC;&#x153;Musical Portraits,â&#x20AC;? the evening featured pieces that recall the meaningful connection between sight and sound.

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Alfred Sommer, M.D., M.H.S., Jill Sommer, Carolyn Lichter, and Paul Lichter, M.D., at the dinner celebrating guest speakers and ophthalmologists who practice in the region.

National Eye Institute Director Paul Sieving, M.D., Ph.D., with faculty member James Adams, M.D.

Paul Lichter, M.D., at right, with Ann Arbor Symphony Orchestra conductor Arie Lipsky and executive director Mary Steffek Blaske. Dedicated to Discovery

Growth and Beauty: Dedicating the Helmut F. Stern Garden

As Chair of the Community Advisory Board for the Eye Center’s expansion campaign, Helmut F. Stern played a crucial role in the project’s success. To celebrate his generosity, a garden linking the two buildings that form the W.K. Kellogg Eye Center was dedicated in his honor on September 24, 2010. Brian P. Campbell warmly saluted his longtime friend at the event, and Mr. Stern related the joy that being involved in the University brings him. Insite Design planned the garden to serve as both an entrance to the world-class Eye Center and to engage patients’ senses of sight, sound, and smell, said landscape architect Shannan Gibb-Randall. The sculpture incorporated in the garden’s water feature, entitled “Gathered Sounds,” stems from visual elements created in response to sounds in nature, explained Ann Arbor artist Anne Kirby Rubin.

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Artist Anne Kirby Rubin discusses her sculpture â&#x20AC;&#x153;Gathered Soundsâ&#x20AC;? with alumna Martha Wright, M.D.

Paul Lichter, M.D., and Helmut Stern.

Brian Campbell, Mary Campbell, Helmut Stern, and Candis Stern.

Dedicated to Discovery

The themes that echoed through the building campaign are now a reality. The building would allow us to recruit new faculty, expand research efforts, and bring advanced eye care to many more patients. Now it is all happening right before our very eyes.

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A nine-member research team has joined Kellogg, bringing with them new ways of thinking about diabetes-related eye disease. They are working with other Kellogg basic scientists and with our new colleagues at the Brehm Center for Diabetes Research to seek new treatments and cures for diabetes and its complications.

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A new service, the Orbital and Ocular Oncology Service, has been established under the direction of Hakan Demirci, M.D. One of a few such services in the country, Kellogg’s will expand treatment offerings and provide comprehensive, coordinated, and compassionate care to our patients with eye cancer.

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• Three new faculty members have joined our highly regarded Pediatric Ophthalmology Service, enabling us to serve many more children with eye problems. •

Faculty recruited during the past year are well on their way to establishing the Kellogg Eye Center as a nationally known research and treatment center for Graves’ eye disease. They also attend to the aesthetic concerns of these and other patients.

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The next generation of ophthalmologists, our residents and fellows, are delighted to train in one of the newest and most advanced eye centers in the country.

Realizing the Promise

The new Kellogg Eye Center opens its doors to new patient services and expanded research programs.

Anna Momont, M.D., Carol George, R.N., and Michael Smith-Wheelock, M.D., in one of our new operating rooms.

Karen Murphy, O.T.R., in the new Life Skills Center for patients with low vision.

Sudha Nallasamy, M.D., with newborn Ava and her mother during a post-surgery visit. Dedicated to Discovery

“A guiding principle for each of us is that the results of basic research should be used to help patients now.” —Thomas W. Gardner, M.D., M.S.

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Steven Abcouwer, Ph.D., Thomas Gardner, M.D., M.S., and David Antonetti, Ph.D., in the new Kellogg Eye Center.

New Perspectives on Vision Research Collaboration is the key as Kellogg’s newest research team drives toward treatment for diabetic eye disease It was not an easy decision for three senior scientists and another six associates to move their research program to Image of the retina shows damage done by leaking blood vessels in diabetic the University of Michigan Kellogg Eye Center. But as retinopathy and the abundant laser scars from treating it. Thomas W. Gardner, M.D., M.S., describes it, the pieces fell into place as the team began to see that Michigan offered a welcoming culture where scientists embraced Forming new points of view collaboration and the unique style of inquiry that is at Because damage to the blood vessels figures so promithe heart of their work on diabetic retinopathy. nently in diabetic retinopathy, many scientists focus Dr. Gardner, along with Steven F. Abcouwer, Ph.D., their research solely on the vasculature of the eye. and David A. Antonetti, Ph.D., is part of a dynamic Dr. Gardner and his team prefer, instead, to talk in team whose goal is to understand how diabetes inflicts terms of the “whole retina:” the neurons that form damage on the retina and then to vision by sending light converted into use their findings to develop better electrochemical signals to the brain; glial “It stands to reason that treatments for the disease. Says cells that support the metabolism of the Dr. Gardner, “A guiding principle this critical mass of world- neurons and perform immune functions; for each of us is that the results of and the system of blood vessels that are class scientists is sure to basic research should be used to the most visible signs of the disease. help patients now.” Dr. Gardner sees patients in discover new ways to fight The challenge is formidable. Kellogg’s Retina Clinic and conducts Today diabetes affects nearly 24 clinical trials as well as directing a the devastating ocular million people, and another 57 research laboratory. He investigates million have pre-diabetes. By 2050, changes in the retina’s neural tissue and complications of diabetes.” one in three Americans will have the features of diabetic retinopathy that diabetes, according to a new report cause neurons to die. That perspective —Paul R. Lichter, M.D. from the Centers for Disease Conallows new strategies to surface. “When trol. Scientists at the Kellogg Eye Center are driven by you view diabetic retinopathy as a neuro-degenerative the knowledge that diabetes-related eye disease is the disease, you begin to see that other classes of drugs leading cause of irreversible blindness among adults. could be effective in combating it,” says Dr. Gardner. Diabetes affects the blood vessels in the eye, One example is doxycycline, a drug also being resulting in observable changes characterizing a conditested for Parkinson’s disease. After promising results tion known as diabetic retinopathy. The blood vessels in animal models, Dr. Gardner and his team initiated become leaky, leading to retinal swelling, and eventua clinical trial to see whether the drug could reduce ally produce fragile, brush-like branches and scar tissue. the loss of vision in individuals with diabetic retinopaThe result is blurred or distorted vision that can lead to thy. Results from the study are expected in less than blindness if not promptly treated. two years.

Dedicated to Discovery

Cheng-mao Lin, Ph.D., Assistant Research Scientist, with lab staff members Mandy Losiewicz, Jason Keil, and Sumathi Shanmugam, all part of the new diabetic retinopathy research team.

“The glue that holds us together is our common inter Another promising treatment model is emerging est in the disease, despite our different perspectives,” from Dr. Antonetti’s laboratory. He has discovered a observes Dr. Antonetti. small drug inhibitor that blocks a protein well known How will this approach play out at Kellogg? Very to scientists—vascular endothelial growth factor or smoothly, the scientists agree. “Kellogg has a strong VEGF. This protein weakens the blood–retina barrier, group of basic scientists exploring retinal degeneraa tightly sealed structure that protects the retina. The tion and regeneration, the same kinds of problems we discovery of the inhibitor came from Dr. Antonetti’s are investigating,” says Dr. Gardner. Then we have a study of mechanisms involved in the formation and major diabetes research program in breakdown of this important the same building. Dr. Gardner had barrier. Now his lab is engaged in “Michigan has a unique just returned from a meeting with “medicinal chemistry,” fine-tuning the Brehm Coalition, scientists who the drug candidate in hopes of blend of talaent that you employ the kind of broad-based moving it toward clinical testing. would be hard pressed to inquiry that is familiar to his team. A third tack comes from Dr. And finally, says Dr. Gardner, we Abcouwer’s lab, with its focus find almost anywhere else.” have people at Michigan who are on the role of glial cells in diabetic experts in the other complications retinopathy. Glia help maintain —Thomas W. Gardner, M.D., M.S. of diabetes. “Michigan has a unique the well-being of other retinal cells. blend of talent that you would be Innate immune cells called microglia hard pressed to find almost anywhere else.” constantly monitor the retinal environment, extending Not surprisingly, the promise of collaboration arm-like projections into the neural tissue and vascuamong diabetes researchers was a frequent theme durlature that his colleagues study. “These cells undergo ing the building campaign. Department Chair Paul R. distinct changes during the course of the disease, but Lichter, M.D., who recruited the team from Penn State it is not clear whether the changes are beneficial or University, saw the possibilities early on. “It stands to detrimental,” he says. reason that this critical mass of world-class scientists The three investigators pursue their own areas of specialty, but they are a fluid group, pairing up in is sure to discover new ways to fight the devastating ocular complications of diabetes.” various combinations to launch promising new projects. 20

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Ava, held by her mother, was four days old when Dr. Nallasamy confirmed a diagnosis of glaucoma.

1 in 10,000 Kellogg pediatric ophthalmologist treats newborn with rare disease Ava was just two days old and still in the hospital when doctors noticed her cloudy corneas. They immediately suspected childhood glaucoma. It is a rare disease— occurring in just one out of every 10,000 births in the United States—so Ava was quickly referred to the pediatric eye specialists at the University of Michigan Kellogg Eye Center. In childhood glaucoma, the pressure inside the eye is elevated. If not treated early, this pressure can damage the optic nerve and cause irreversible vision loss. On day three of her young life, Ava and her mother, Jenny, traveled from Kalamazoo to Kellogg to see Sudha Nallasamy, M.D., an assistant professor on the Pediatric Ophthalmology and Adult Strabismus Service. Dr. Nallasamy examined Ava and found many signs of childhood glaucoma—cloudy corneas, elevated pressures, and asymmetrically enlarged corneas. To confirm the diagnosis, Dr. Nallasamy scheduled an examination under anesthesia for the next day, with the possibility of surgery. 22

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Ava is the first child in her family and her mother was overwhelmed by the thought of her newborn undergoing surgery. Dr. Nallasamy calmed her fears and explained that moving forward with surgery was the best option for treating the glaucoma and saving her baby’s vision. As Ava’s mother observed, “Dr. Nallasamy was very patient and answered all of our questions.” Dr. Nallasamy performed a surgical procedure, called a trabeculotomy, on both eyes. An opening is created in the eye’s impaired drainage channel, allowing fluid to properly flow out of the eye and thus relieve pressure. This procedure can successfully treat childhood glaucoma roughly 80 percent of the time. “After multiple follow-up appointments, Ava’s pressure has stabilized and her vision is developmentally appropriate,” says Dr. Nallasamy. “But, she still needs careful follow-up to be sure her eye pressure remains controlled.” “We understand what we have to do from here, but we’re just so thankful the problem was caught and treated early,” says Ava’s mother. “This was our first experience with Kellogg and we’re so happy with the outcome,” she adds. “Dr. Nallasamy has given Ava great personal care, calling to check on her several times after the surgery. After all we’ve been through, we’ve learned what a great place Kellogg is and how nice it is to have such a superb eye center nearby.”

“After all we’ve been through, we’ve learned what a great place Kellogg is and how nice it is to have such a superb eye center nearby.”

Dedicated to Discovery

“With new gene expression profiling tests, we’ll be better able to plan treatments that may prevent the spread of cancer for certain patients.” —Hakan Demirci, M.D.

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Expanding Services for Patients with Eye Cancer Creating a wide network of specialists and eliminating the hassle The most common type of primary eye cancer, uveal melanoma, affects a relatively small number of people, fewer than 2,500 in the U.S. each year. But an uncommon disease creates other complications. Many patients will need to travel a considerable distance to find an expert in ocular oncology. As director of Kellogg’s new Orbital and Ocular Oncology Service, Hakan Demirci, M.D., is determined to ease the way for his patients, helping them navigate a large and often confusing health system. “Once patients find our clinic, we quickly connect them with specialists who can provide the best care possible.” Dr. Demirci, associate professor of ophthalmology and a member of the U-M Comprehensive Cancer Center, is formalizing a network of specialists to streamline his patients’ care. His starting point is this department, where he has immediate access to experienced physicians specializing in pediatric ophthalmology, oculoplastics, and tumors affecting the cornea, iris, retina, and orbit. In addition, Dr. Demirci has established close ties with oncologists at Michigan’s Comprehensive Cancer Center, enabling him to consult with specialists in radiology, melanoma, radiation oncology, and pediatric oncology. These connections assure that patients receive multidisciplinary care, careful monitoring of their condition, and a wide range of treatment options. With another team of oncology specialists, Dr. Demirci is evaluating a new treatment for retinoblastoma, a life-threatening cancer affecting young children. Intra-arterial chemotherapy delivers medication directly to the tumor via a catheter placed in the artery that feeds the eye. This targeted treatment, available in only a few medical centers, shows promise for increasing control of the tumor while reducing systemic side effects that occur with traditional chemotherapy. “We are carefully assessing the dose and type of agents used in the treatment, as well as cases in which it can be used safely and effectively,” says Dr. Demirci. Thanks to advances in ocular oncology genetics, Dr. Demirci is providing his patients with genetic

testing that can assess the risk of metastasis in uveal melanoma. “With new gene expression profiling tests, we’ll be better able to plan treatments that may prevent the spread of cancer for these patients,” he says. Dr. Demirci’s new post marks a homecoming. He completed an eye plastic fellowship at Kellogg in 2006 with Christine C. Nelson, M.D., now chief of the service; Victor M. Elner, M.D., Ph.D.; and the late Bartley R. Frueh, M.D. He also completed a fellowship in ocular oncology and worked at the Wills Eye Institute in Philadelphia. While Dr. Demirci is enthusiastic about advances in treatment, he is well aware of his patients’ most basic need—to receive excellent care without confusion. “Our doctors and staff will help patients with whatever they need—from arranging appointments at the hospital to hotel reservations. We want to simplify their experience and keep their focus on healing,” he says. “It’s the least we can do for our patients.”

Among Kellogg’s ocular oncologists are (seated) Hakan Demirci, M.D., Christine Nelson, M.D., and (standing) Shahzad Mian, M.D., Steven Archer, M.D., Victor Elner, M.D., Ph.D., Alan Sugar, M.D., H. Kaz Soong, M.D., and Alon Kahana, M.D., Ph.D. Dedicated to Discovery

“Simply put, we have the best optics available in our new ORs.” —Michael W. Smith-Wheelock, M.D.

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A Good Trip to the OR New surgical floor offers comfort and cutting-edge technology Patients who come to the University of Michigan Kellogg Eye Center for surgery will partake in a whole new experience when they visit our new surgical floor. The first thing patients will notice is the spacious waiting area, set in calming soft tones with great views of the medical campus and surrounding nature areas and featuring a large screen digital television, two Internetconnected computers and free Wi-Fi access. The most impressive aspects of the new surgical floor, however, are beyond the waiting area and behind the scenes. Kellogg’s new operating rooms are the first in the world to feature the Zeiss OPMI Lumera 700 ceilingmounted surgical microscope, a cutting-edge microscope that we have fitted with high-definition cameras that can transmit images to video-feed screens throughout the building. “Simply put, we have the best optics available in our new ORs,” says Michael W. Smith-Wheelock, M.D. For patients, this can improve their surgical outcome and, for residents, this can improve their learning. “The new microscopes are great,” says Co-Chief Resident Anna Momont, M.D. “We have the best views possible, which is important when you’re doing cataract surgery. And our new ability to tape surgical cases in HD provides a tremendous teaching tool.” The Wilkinson Family Surgery Observation Suite adjoining one of the new operating rooms also enhances surgical training. This room allows fellows, residents, medical students and technicians to observe the whole range of surgical cases. “With the exception of the observation room, each operating room is identical so they are all used equally,” explains Carol George, R.N. “And each room is equipped with the same supplies and instruments, which are now sterilized on-site instead of being sent to the University Hospital. All this helps us function so much more efficiently.” All the operating rooms feature an integrated communications technology system that posts realtime surgery updates. “For the first time, we have our OR schedules available on large monitors, which helps maintain an efficient patient flow and also allows us to keep patients and their families updated on the

Anna Momont, M.D., Carol George, R.N., and Michael Smith-Wheelock, M.D., in one of Kellogg’s new high-tech operating rooms.

progress of their family member’s procedure,” says Dr. Smith-Wheelock. The new surgical area also has made it easier to care for patients before and after surgery. The new preop and post-op areas are larger and better organized. Nurses are better able to track the status of patients and patients have more privacy. These areas are welcoming, with comfortable, custom-made beds and artwork featuring scenes throughout the state of Michigan. A new consultation room allows Kellogg surgeons to talk privately to patients and their families. The on-site pharmacy is another example of the exceptional design of the surgical floor. It is staffed by a full-time registered pharmacist and stocks most of the ophthalmic medications prescribed by our surgeons. Patients now have the convenience of picking up their prescriptions before leaving the building. When thinking about the opening of the new operating rooms, Ms. George says, “We used to do such great work in a small place so I’m excited to see what’s on the horizon for us in this spectacular new space.” Dedicated to Discovery

“When I couldn’t read, I felt like I was losing everything.” —Mrs. Gragg

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Patients with Severely Reduced Vision Find a Few New Tools Make All the Difference Kellogg helps patient maintain vision for reading and for independence

Karen Murphy, O.T.R., with a TV monitor adapted to magnify newspapers, bills, letters, and other reading material. Opposite page: Ms. Murphy visits Clara Gragg in her home.

tools such as large-print checks for paying her bills. For more than 20 years, Clara Gragg worked as a One area where Mrs. Gragg struggled, however, teacher in her community’s Head Start program, was medication management for her diabetes. When helping preschoolers develop reading skills. So, when her daughter, Estella Gragg-Carson, stopped by for a Mrs. Gragg began to struggle with her own reading, visit, she immediately knew something was wrong. She she turned to the University of Michigan Kellogg Eye discovered that her mother had been having trouble Center for help. measuring her insulin. Soon thereafter, Mrs. Gragg was “When I couldn’t read, I felt like I was losing hospitalized with dangerously high blood sugar levels. everything,” says Mrs. Gragg, 89, who suffers from Upon discharge, she and her daughter met with Ms. glaucoma and cataracts, as well as diabetes. As Murphy to come up with a better her vision worsened, it was retina plan for handling medications. specialist David N. Zacks, M.D., “Our Living Skills Center Ms. Gragg-Carson is very Ph.D., who referred her to involved in her mother’s care and Kellogg’s Low Vision Clinic. provides a very realistic now visits every Saturday to set up The expanded Low Vision and all her medications for the week. Visual Rehabilitation Clinic has environment in which to Most important, though, Ms. Murtwo new centers—the Technology phy recommended that Mrs. Gragg Center and the Independent Living train our patients how to use a talking glucose meter to help Skills Center—to help patients function in their own homes.” her keep her blood sugar in check. learn to use optical aids and other Mrs. Gragg remains active and devices that make the most of —Karen Murphy, O.T.R. independent. While she does have their vision. Our optometrists and in-home care twice each week, she occupational therapist also teach attends church every Sunday and walks almost every patients to use aids that help with daily activities, day. Thanks to help from Ms. Murphy, she pays her from reading to financial management. bills, manages her low vision devices, and checks out “Our expanded clinic is working well for us,” says books on tape from the Washtenaw Library for the occupational therapist Karen Murphy, O.T.R. “We have Blind and Physically Disabled. wonderful new equipment and a lot of space for our “When you have a disability, you need to accept it,” patients to come in and use it. Our Living Skills Center says Mrs. Gragg. “It just makes everything worse if provides a very realistic environment in which to train you try to resist it.” While the loss of vision has been our patients on how to function in their own homes.” difficult, Ms. Gragg-Carson credits the Low Vision Mrs. Gragg began working with Ms. Murphy in Clinic for opening so many doors to help her mother this clinic and then arranged to have the occupational maintain her independence. therapist come to her home. This was where she learned “Everyone at Kellogg is very courteous, considerate, to make reading easier using various magnifiers and a and compassionate toward my mother and I feel very closed-circuit television. Ms. Murphy also made lighting comfortable knowing she’s receiving the best care,” and safety recommendations in the home, adapted her says Ms. Gragg-Carson. cooking areas, and introduced Mrs. Gragg to useful Dedicated to Discovery

university of michigan kellogg eye center

Videos from these residents can be seen on our website. Clockwise from top, Eric Schneider, M.D., Anna Momont, M.D., Benjamin Kramer, M.D., Dolly Padovani-Claudio, M.D., Ph.D.

Kellogg’s New Building a Prize for Teaching New faculty and new programs give residents many opportunities to learn When the new building opened its doors last April, patients weren’t the only ones to notice big changes. Residents, fellows, and medical students also found themselves in a new environment with extraordinary possibilities for education. Residency Director Shahzad I. Mian, M.D. was quick to cite the educational benefits of the new building. “More space has allowed us to recruit many more faculty members, which means that the residents interact with more clinicians and scientists,” he said. The variety of individuals from whom our residents can learn—in the clinics, the ORs and, during their research rotations, the laboratories—has increased substantially. The building has also allowed us to establish new programs, like our expanded Ocular Oncology program. “This program,” says Dr. Mian, “automatically enhances teaching because it is a fabulous opportunity that residents can get at just a few other places.” More faculty, of course, also means more opportunities for residents to perform surgery. Last year, for example, operating time for pediatric surgery was limited to one day. Now, with a larger pediatric ophthalmology team, our residents get more surgery time and have the chance to interact with a larger variety of physicians in the clinic. According to second-year resident Eric Schneider, M.D., “The expanded clinical space has dramatically improved the training experience. The space is both larger and better integrated, allowing residents to see a greater number of patients as well as confer more easily with other subspecialists.” The new building also has enhanced equipment. “Many exam rooms are equipped with slit lamp cameras,” notes Dr. Schneider. “This means that all trainees—medical students, residents, and fellows—can appreciate a particular patient’s clinical findings simultaneously in real-time, allowing

Residency Director Shahzad Mian, M.D., in the surgical observation room with second-year resident Eric Schneider, M.D.

for great case discussions.” In addition, each of the operating rooms is equipped with recording equipment, special microscopes, large monitors to allow residents to view the surgery from the observation room, and special cameras that are mounted in the overhead lights. According to Dr. Mian, “the fact that all operating rooms have the same equipment gives greater flexibility in coordinating surgical cases between the various subspecialties. This is a tremendous benefit.” The design and beauty of the new building also helps us to recruit residents and fellows. “Our building really stands out,” says Dr. Schneider. “No one’s going to forget Kellogg once they’ve been here.” Dr. Mian sums it all up: “The difference is simply amazing. The building is light, the colors are warm, there is beautiful artwork in every corridor. It’s wonderful for morale. We love to come to work here. Anyone can see that this building design is not opulent; all the space is well utilized. The building is true to who we are as a culture.” Dedicated to Discovery

Dean James Woolliscroft, Alon Kahana, M.D., Ph.D., and Helmut Stern.

Dr. Kahana with his wife, Heidi, and children (clockwise) Arielle, Kyra, Ethan and Adam.

Career Development Professorships Are Established by Helmut F. Stern and by the Dryer Foundation Two new professorships provide junior faculty with important research support Families, friends, and colleagues came from across campus and across the country to help two faculty members celebrate their installation into newly established career development professorships this fall. Special ceremonies honored the generosity of both the Edward T. and Ellen K. Dryer Charitable Foundation and of Helmut F. Stern and recognized the achievements and the potential of Grant M. Comer, M.D., and Alon Kahana, M.D., Ph.D. “I am deeply honored,” said Dr. Kahana, who was named the first Stern Professor. “A career development professorship supports a junior faculty member at the beginning of his or her career, when resources are desperately needed and hard to come by. It’s a tribute to Mr. Stern and to the Dryer Foundation that they had the foresight to make these investments.”

university of michigan kellogg eye center

In accepting a medal commemorating the inauguration of the Helmut F. Stern Career Development Professorship, Mr. Stern, an Ann Arbor businessman and philanthropist, remarked that he appreciated the opportunity to participate in the intellectual life of the university. “Support of worthwhile causes is as essential as our daily bread,” he said. Mr. Stern grew up in Germany and settled in Ann Arbor in 1942, where he served as president of Industrial Tectonics and later as president of Arcanum Corporation. A longtime supporter of the mission of the Kellogg Eye Center, he served as Chairman of the Community Advisory Board for the recent expansion campaign. He has generously contributed to research and educational endeavors over the years, including the work of Dr. Kahana. Dr. Kahana is a member of the Eye Plastic, Orbital and Facial Cosmetic Surgery Service at Kellogg. The professorship will help him expand his research on the biology and development of the extraocular muscles

Jon Gandelot, Lisa Gandelot, Grant Comer, M.D., Alicia Comer, Paul Lichter, M.D., Judith Drobot, and Joseph Drobot, Jr.

Grant Comer, M.D., his wife, Alicia, and children Maya and Garrett.

by his employer because of his condition, he created his surrounding the eye as well as neural crest-derived stem own opportunities for success. He kept in touch with cells in the orbit. His work could help improve care in colleagues and made his living by investing in the stock orbital cancer, craniofacial syndromes, congenital eye market. Mrs. Dryer was an advertising pioneer who disorders, and thyroid-related eye disease. served as W.B. Doner & Company’s first female media “Alon is an energetic collaborator,” said Christine director. When she came home from work in the eveC. Nelson, M.D., Professor of Ophthalmology and ning, she read her husband the stock reports. Mr. Dryer Visual Sciences, as she introduced Dr. Kahana. “He also urged large publicly traded companies to put their wants to involve other people in his ideas, and he is annual reports on audio tapes so generous in sharing his projects and “This valuable award will that he and others could listen to his time. Alon works with scientists them. The Dryer Foundation continhere and across campus to further his provide the opportunity ues to honor their goals. research and help others make prog“This valuable award will ress as well. And he works with our to diminish vision loss by provide the opportunity to diminish faculty and with physicians across vision loss by developing a number campus to make sure his patients have developing a number of of clinical research studies based the most effective care.” at Kellogg,” said Dr. Comer, who Dryer Foundation trustees Lisa M. clinical research studies specializes in diseases of the retina, and Jon B. Gandelot and Judith L. and including age-related macular Joseph A. Drobot, Jr., are pleased that based at Kellogg” degeneration. Dr. Comer, as the first Dryer Professor, The career development profeswill broaden his patient education and —Grant M. Comer, M.D. sorships will be held by Drs. Comer research efforts, especially in the area and Kahana for five years, after which they will be given of clinical trials. The Dryers, who lived in Detroit and to other junior faculty members launching promising who passed away within months of each other in 2001, research programs. “These professorships are remarkestablished the foundation through their estate plans in able,” said Paul R. Lichter, Director of the Kellogg Eye part to help individuals battling eye disease. Center. “They will touch many careers and improve Mr. Dryer, an international banking executive, was many lives through the research they support.” struck by blindness in the middle of his career. Let go

Dedicated to Discovery

“I appreciate the Eye Center’s focus on preventing eye disease, and I would like to see even more children benefit, as I did, in future years.“ —Timothy Wadhams

university of michigan kellogg eye center

A Winning Vision Timothy and Laurie G. Wadhams honor Dr. Harold Falls Vibrant artwork, a stimulating play center, and a tank full of brightly colored fish welcome children to their eye appointments—and to the Harold F. Falls Pediatric Harold F. Falls, M.D. Reception Area. Harold F. Falls, M.D., was an ophthalmologist renowned for his early contributions to the field of preventing eye disease, and I would like to see even genetics. He devoted his career to building a rich more children benefit, as I did, in future years,” he says. collection of family histories of eye disease. He also Dr. Falls, who passed away in 2006, is still fondly cared for many children. remembered by many patients and colleagues. “Many One of them was Timothy Wadhams, who today experts consider Dr. Falls to be the founder of mediis CEO of Masco, a Taylor, Michigan-based company cal genetics in this country,” says Paul R. Lichter, that is one of the world’s largest manufacturers of home M.D., Chair of the Department of Ophthalmology and improvement and building products. Mr. Wadhams Visual Sciences. “He had profound insights into mediwas treated by Dr. Falls for strabismus as a child, and cal genetics in the early 1940s, well ahead of his peers he and his wife, Laurie, this year made a generous in any medical field. His colleagues pledge of support to the Kellogg Eye “Laurie and I are pleased in ophthalmology regard him as the Center to honor Dr. Falls. undisputed master of clinical genetics “I had five or six surgeries before to be able to help the Eye in ophthalmology.” I entered elementary school and two Dr. Falls completed his medical later on, and the successful outcomes Center and to recognize education and a residency in ophthalmade a big difference for me,” Mr. mology at the University of MichiWadhams says. “I had a pretty severe Dr. Falls.” gan. In 1941 he helped to establish case of strabismus, and Dr. Falls the U-M Heredity Clinic, widely mentioned to my parents that I most —Timothy Wadhams recognized as the first such clinic in likely would have difficulty with handthe nation. He retired as a professor of ophthalmology eye coordination and limitations in the types of in 1975. Dr. Falls held numerous leadership positions activities that I would be able to participate in.” in local, state, and national medical associations. After the surgeries, however, he not only participated “I recall Dr. Falls as a thoughtful, gentle man with in a variety of youth sports, he played football and a good sense of humor,” Mr. Wadhams says. “I was basketball at Ann Arbor High School and played always very comfortable with him and felt that he was football for four years at the University of Michigan. truly interested in me as a person. As I look back, I “Dr. Falls’ ability helped me both cosmetically and feel very fortunate to have had such outstanding care. functionally, allowing me to enjoy success in athletics, Sometimes when we are young, we tend to focus on our which were a huge part of my youth,” he says. own problems and their implications. As you experience Mr. Wadhams, who earned a bachelor’s degree in life, you realize that everybody has challenges and issues economics and a master’s degree in business administraand you come to appreciate the advancements in science tion at U-M, has maintained close ties to the University and technology to address those challenges. Laurie and over the years, including serving on the Community I are pleased to be able to help the Eye Center and to Advisory Board for the Kellogg Eye Center’s expansion recognize Dr. Falls.” campaign. “I appreciate the Eye Center’s focus on Dedicated to Discovery

The Harold F. Falls Pediatric Reception Area is part of the Carls Pediatric Ophthalmology Clinic at the Kellogg Eye Center, which was named in honor of the late Detroit industrialist William Carls through a generous contribution by his foundation. Such named spaces are a special part of the expanded Eye Center facility and are facilitated through gifts that support capital projects as well as research programs. Other spaces named in honor of individuals include:

John F. & Casilda Daly Retina Reception Area. Mr. and Mrs. Daly made a significant gift to the new building. A member of the expansion campaignâ&#x20AC;&#x2122;s Community Advisory Board, Mr. Daly was CEO of Hoover Universal and vice chairman of Johnson Controls.

Brehm Tower. The addition to the Kellogg Eye Center is named the Brehm Tower for William and Delores Brehm. The building also houses the Brehm Center for Diabetes Research on the fifth and six floors. The Brehmsâ&#x20AC;&#x2122; goal is to find a cure for type 1 diabetes, which Dee Brehm has coped with for more than 60 years. Bill Brehm is chairman emeritus of SRA International.

Richard & Jane Manoogian Lobby. The Manoogians provided strong support for the expansion campaign. Richard Manoogian is executive chairman of Masco Corp.

Lynn H. & Robert W. Browne Glaucoma Reception Area. The Brownes supported our growth through a gift to the new building. Dr. Browne earned his undergraduate degree as well as advanced degrees in dentistry and orthodontics at U-M. He is CEO of Trust Investment Management Corporation. 36

university of michigan kellogg eye center

Ida Lucy Iacobucci Orthoptic Clinic. Miss Ida has served on the faculty for more than 52 years, working with children and adults to overcome conditions that affect eye movement and eye muscles.

The Leonard G. Miller Comprehensive Ophthalmology Clinic and the Leonard G. Miller Microscopy Suites. Mr. Miller supported the expansion and purchased important microscopy equipment for the department that is helping research move forward in exciting ways. Mr. Miller was a founding partner of Molmec, Inc., a major supplier of molded plastic components for the automotive industry.

Named Spaces

Leave Special Mark in New Building

Harold “Red” & Marian Poling Lobby. Mr. and Mrs. Poling were early contributors to the new building campaign and have supported research efforts as well. Mr. Poling is retired Chairman and CEO of Ford Motor Company. Helmut F. Stern Garden. Mr. Stern served as Chair of the Community Advisory Board for the expansion campaign, and he supports numerous other projects. He was president of Industrial Tectonics and of Arcanum Corporation. The Robert & Ellen Thompson Vision Research Conference Center. The Thompsons made an early, important gift to the new building campaign. Mr. Thompson founded the Thompson Foundation after selling the Thompson-McCully Company, Michigan’s largest asphalt paving firm. The Harry A. & Margaret D. Towsley Foundation Ophthalmic Photography Center. The Towsley Foundation, which has a long history supporting the Eye Center, helped fund our efforts to establish a new state-of-the-art ophthalmic photography center.

Rachel Mary Upjohn Lobby. The lobby on the first floor is named for a wonderful supporter and her grandmother, who shared the name Rachel Mary Upjohn. Later known as Mary Meader, the granddaughter of William E. Upjohn, and her husband, Edwin Meader, for years helped spur the growth of the Kellogg Eye Center’s programs and facilities. Mr. Meader was a military intelligence professional and Mrs. Meader was an adventurer who took the first aerial photos of Africa. Wilkinson Family Surgery Observation Suite. Mary June Wilkinson, along with her late husband, William C. Wilkinson, M.D., an alumnus, made the very first gift to the Eye Center expansion project. Their son, W. Scott Wilkinson, M.D., also an alumnus, and his wife, Jill, support the Eye Center as well. We also gratefully acknowledge the friends of the Eye Center who have named examination rooms, specialty service rooms, and laboratory areas as well as all of the donors who contributed to our expansion campaign and continue to support our mission.

Dedicated to Discovery

Bartley Frueh, M.D., with his wife, Cheryl; Calligraphy rendering of the Chinese poem, “River Snow,” in the form of an eye chart; and Dr. Frueh after surgery.

The Life of Bartley R. Frueh, M.D. On February 16th we lost a friend and colleague when Bartley R. Frueh, M.D., passed away. He was the founder of our oculoplastic service as well as our oculoplastic fellowship program. When Dr. Frueh was asked to form this subspecialty service in 1979, the field was relatively new and the plastic surgeons in the hospital resisted the notion that others were qualified to perform plastic surgery. However, with both tenacity and patience, Dr. Frueh was able to convince them that oculoplastic surgery had its own particular set of complexities that ophthalmologists could best resolve. Within a few years, our service was growing and the plastic surgeons had become colleagues who called upon Dr. Frueh for his expertise when they were faced with surgeries involving the eye. Dr. Frueh also established an accredited Eye Plastic, Orbital and Facial Cosmetic Surgery fellowship program, one of the first in the country. It has since become one of the finest. From the very beginning, Dr. Frueh strongly emphasized research and the consequence is that this service today is arguably the most active in the country in terms of basic research. The ophthalmologists in this two-year fellowship are expected to be active participants in research, publishing papers with faculty and submitting abstracts to national meetings. Recognized for his particular expertise in Graves’ eye disease and eyelid function, Dr. Frueh was called upon to give lectures around the country and was 38

university of michigan kellogg eye center

honored to give the American Society of Ophthalmic Plastic and Reconstructive Surgery’s prestigious Wendell L. Hughes Lecture in 1993 and the Kellogg Eye Center’s F. Bruce Fralick Lecture in 2003. He published over 100 peer-reviewed articles in his field. Dr. Frueh was also known for his many life-long interests outside of medicine, among them Roman history and archaeology, coin collecting, rebuilding antique automobiles, and woodworking. When he retired last year, he and his wife, Cheryl, traveled extensively, including several visits with friends and colleagues in Australia, where Dr. Frueh had taken two sabbaticals. The Fruehs also participated in an archaeological dig outside Rome. Yet he also found the time to continue to see patients here at the Kellogg Eye Center. The walls inside his clinic display a special tribute to Dr. Frueh. During his retirement he had become immersed in the study of Chinese calligraphy. He painted many beautiful scrolls, several of which are exhibited on the third floor of the Brehm Tower at the Kellogg Eye Center. Dr. Frueh’s parents taught him to value education. To honor them, Dr. and Mrs. Frueh established the Lloyd and Virginia Frueh Research Professorship in Eye Plastics and Orbital Surgery at the University of Michigan. Dr. Frueh had a tremendous influence on the growth of our oculoplastic service, on our residents and fellows, and on his colleagues and friends. We miss him.

Alumni and Friends Lend Support to a New Collegiate Professorship Collegiate professorships are among the greatest honors we can bestow on a faculty member. They are named for individuals who made substantial and distinguished contributions while at Michigan. A longtime faculty member and former director of the Residency Program, Dr. Terry Bergstrom’s most enduring legacy is as an educator. He has trained more than 200 ophthalmology residents and fellows and has taught thousands of medical students. Alumnus W. Scott Wilkinson, M.D. says “His unique combination of encouragement, clear thinking, and the occasional velvet brick to the forehead helped us all to develop confidence in our technical skills and, more importantly, sound clinical judgment.” Our goal is to inaugurate the professorship at a special event during Spring Conference. The following individuals are helping make that possible through their generous gifts and pledges.

Alumni and friends share a light moment with Terry Bergstrom, M.D. (lower right) during Fall Reunion Weekend.

$50,000 and above

$5,000 to $9,999

$500 to $999

Kenneth H. (R ’69) Musson and Patricia Musson Michael (R ’82) and Karen Pachtman

Harry E. (R ’81) and M. Patricia Bash Mr. Daniel and Dr. Holly M. Gross (R ’95) Michael Petersen (R ‘90) and Elizabeth Binasio Dr. S. Harry Robertson, P.E. Gregory L. Skuta, M.D. Ronald E. Warwar, M.D. (R ’96) Fuxiang and Fenfen Zhang (R ‘97)

Drs. Everton (R ’90) and Saundrett Arrindell Brian P. Brooks, M.D., Ph.D. (R ’01, F ’02) Dr. Theresa (R ’01, F ’02) and Mr. Frank Cooney James D. Izer, M.D. (R ’02) Patrick J. Parden, M.D. (R ’84) Drs. Penporn (R ’06) and Stephen Reck (R ’06, F ’07) Dr. Ralph and Judith Sawyer Becky Spaly Peter K. Speert, M.D., J.D. (R ’85)

$25,000 to $49,999 Jason M. Burgett, M.D. (R ’97) Scott M. Corin (R ’87) and Nina Blumenthal Dr. and Mrs. Gary Haynie (R ’91) David (R ’66) and Jayne VerLee

$15,000 to $24,999 Amjad Z. Ahmad, M.D. (R ’98, F ’00) Richard (R ’87) and Lisa Garfinkel David S. Hemmings, M.D. (R ’98) Richard L. (R ‘88, F ‘89) and Kay E. Watnick W. Scott Wilkinson (R ’89)

$2,500 to $4,999 Stephen Boorstein, M.D. (R ’96) William S. Clifford, M.D. Gayle Dickerson Dasa (R ’92) and Nalini Gangadhar Sunir J. Garg, M.D., F.A.C.S. (R ’02) Michael A. Kipp, M.D. (R ’97, F ’98) Michael (R ’00) and Linda Smith-Wheelock James F. Vander, M.D. (R ’88)

$10,000 to $14,999 Anthony (R ’89) and Mary Adamis Keith D. (R ‘87) and Cheryl D. Carter Keith (R ’80) and Susan Kobet Carolyn and Paul Lichter (R ’68) Kim Lindenmuth (R ’87, F ’88) and Matthew Bueche Keith (R ’68) and Della McKenzie Mark (R ‘94) and Kimberly Phelan Rennie and Michael Roth (R ’77) Lee S. (R ‘95, F ‘96) and Stephen T. Webster

$1,000 to $2,499 Mark (R ’70) and Judith Cohen Ralph P. Crew, D.O. (F ’90) Bita Esmaeli, M.D. (R ’94) Ayad A. Farjo, M.D. (R ’00, F ’01) and Karin R. Sletten, M.D. (R ’01) Robert (R ’84) and Teresa Grosserode Kenneth B. Gum (R ‘88) Katherine A. Lee, M.D., Ph.D. (R ’98) Gary Lelli (R ’06) and Kelly Bottger Drs. Thellea K. (R ‘05) and J.C. Leveque Margaret W. Vezina Daniel M. Wolner, M.D., Ph.D. (R ’92) Jeff (R ‘05) and Kate Zink

Up to $499 Anonymous Donor (1) Steven A. Boskovich, M.D. (R ’91) Dorothy M. Damon Edward F. Hall, M.D. (R ’06, F ’08) Dr. and Mrs. David G. Heidemann (R ’86) Michael and Jessica Ober Jared W. Parker, M.D. (R ’08) Warren J. Scherer, M.D., Ph.D. (R ’96) and Nancy Scherer Amit Tandon, M.D. (R ’07)

Generous alumni and friends have contributed close to 90 percent of our $500,000 goal. If you would like to make a gift in support of the Terry J. Bergstrom Collegiate Professorship, please contact Gayle Dickerson at 734-647-7382 or gayled@umich.edu. Dedicated to Discovery

With gratitude for gifts made from July 1, 2009, through June 30, 2010

Annual Honor Roll of Donors With heartfelt thanks to donors who made gifts from July 1, 2009,

$50,000 to $99,999

$5,000 to $9,999

Anonymous Donor (1) The Campbell Fund Frances and David H. Grossman Michigan Eye-Bank

Anonymous Donor (1) Herbert and Carol Amster Harry E. and M. Patricia Bash Frank and Barbara Batsch Michael and Joanne Bisson Scott M. Corin and Nina Blumenthal Jean E. Craig Joe and Beth Fitzsimmons Richard and Lisa Garfinkel Helen and Richard Kerr Michael R. Petersen, M.D., Ph.D., and Elizabeth Binasio S. Harry Robertson Karan and William Selezinka Alan and Gail Sugar Michael A. Wainstock, M.D. Ronald E. Warwar, M.D.

through June 30, 2010. Included in

$10,000 to $49,999

this listing are contributors whose

Anonymous Donor (1) Birkhill Family Foundation Mary L. Boyers Trust Thomas W. Breakey Ruth F. Clarke Estate Cosmetic Surgery Foundation Marguerite Damer Ann and Joseph W. Edwards Fight for Sight Elaine Frick James T. and Charlene L. Glerum Dr. and Mrs. Gary Haynie Howard Hughes Medical Institute W.R. Kenley The Knights Templar Eye Foundatiion Carolyn and Paul Lichter Keith and Della McKenzie The Meijer Foundation Joel and Susan Mindel Michael and Karen Pachtman Mickey and Karen Shapiro Elmer and Sylvia Sramek Charitable Foundation Mildred E. Swanson Foundation

donations are part of multi-year pledges. $1 million and above Anonymous Donor (1) Edward T. and Ellen K. Dryer Charitable Foundation

$500,000 to $999,999 The Foundation Fighting Blindness Larry G. Miller The Ravitz Foundation

$100,000 to $499,999 Edward P. & Kathryn M. Bellas Trust The Carls Foundation Bartley R. and Cheryl T. Frueh M. & H. Ghandour The Lincy Foundation Richard and Jane Manoogian Research to Prevent Blindness The Harry A. and Margaret D. Towsley Foundation

$1,000 to $4,999 Anthony and Mary Adamis James and Kathryn Adams Steven and Carol Archer Everton and Saundrett Arrindell Betty Baier and Mark Kesson David and Nancy Barbour Anne and Terry J. Bergstrom Miriam E. & Fred G. Blum, Jr. Eleanor E. Brownell Keith D. and Cheryl D. Carter Janet and Bill Cassebaum Mark and Janet Cichowski

“I am so proud of this facility. It is spectacular. You can feel the sense of excitement. My hope is that we use the potential that we have built around us to continue to grow and to practice medicine in a way that is worthy of the standards our predecessors established and will serve as a source of pride for those who follow in our steps.” — Michael Smith-Wheelock, M.D., Assistant Professor

university of michigan kellogg eye center

of Ophthalmology and Visual Sciences, speaking on

the occasion of the dedication of the Brehm Tower

at the Kellogg Eye Center, April 23, 2010

With gratitude for gifts made from July 1, 2009, through June 30, 2010 Mark and Judith Cohen Claude M. Coleman Michele Tameris Cook Katherine and Ralph Crew Damon’s Grill Gloria P. and William E. Dean, Jr. Jane and Irwin Deister, Jr. Rosemarie DeLand Monte A. and Kristen G. Del Monte Sandra and David Detrisac J. McGregor and Christine Dodds Dr. and Mrs. Paul A. Edwards Douglas P. and Shelley Felt Victor P. Freliga Margaret E. Gallup Larry and Mary Gerbens E. Paul Gieser, M.D. Marian L. Gotshall Daniel and Norma Green Robert and Teresa Grosserode Jerome B. Grossman Richard F. Gutow Kenneth Alan Haller Myron Hepner Barry P. and Mary Ann Hoffman Robert O. and Carolyn S. Hoffman Walter and Barbara Hungerford Professor Judy M. Judd Dr. Alon and Heidi Kahana Nancy and Jeffrey Khan, M.D. Keith and Susan Kobet Susan J. Lane Hugh Logan William W. Love Dr. Marvin and Sue Lubeck James Albert Maraldo Donald and Jacqueline McCulloch Beverly A. McKenney Dr. Corey A. Miller and Nancy J.Miller James and Marina Mitchell Andrew L. Moyes, M.D. Kenneth H. Musson and Patricia Musson Bruce and Roberta Oliver Mark E. and Barbara C. Overland Mark and Kimberly Phelan Scott M. Pinter, M.D. James and Nancy Ravin James Michael Rosenfield Dr. Ralph and Judith Sawyer Marcia and David Schmidt Don and Jane Schriver Sigma Xi Society Michael and Linda Smith-Wheelock H. Kaz Soong, M.D. Peter K. Speert Carol Standardi The Stempler Family Foundation Duane L. and Sheila P. Tarnacki

James B. Thompson and Mary Ann Brandt Susan and David Thoms Triford Foundation Margaret W. Vezina Genevieve E. Walinski Danny D. Wang and Yili Wang Herbert E. Weston George C. Whitaker Marina V.N. and Robert F. Whitman Jung and Chiung Yao Wu Fuxiang and Fenfen Zhang

$500 to $999 Anonymous Donors (3) Gerald and Gloria Abrams Roger D. Arnett Lana and David Berry Elizabeth A. Bertz Robert D. Biggs, M.D. Garry N. Binegar, M.D. Henry A. Boldt, Jr., M.D. James and Jacqueline Bowen Carl A. Brauer, Jr. Christine R. Buse Richard and Enid Carlin William S. Clifford, M.D. Jim and Marty Conrad Mr. Frank and Dr. Theresa Cooney Morton S. Cox Kim and Loraine Cranor Roland and Louise W. DeMartin Gayle D. Dickerson Robert and Cassandra Estes Janet and L. Scott Feiler, M.D. Dennis and Christine Fornal Jacqueline A. Forrest Philip J. Gage and Wendy Rampson-Gage Sunir J. Garg Millicent Higgins, M.D. Nathan and Shelley Johns James A. Johnson Virjean Johnson Daniel and Rose Kachnowski James G. and Carolyn Knaggs Ann Novak-Krajcik and Joseph S. Krajcik, M.D. C. Byron Landis, M.D. Richard Alan Lewis and Patricia N. Lewis Kim Lindenmuth and Matthew Bueche Dr. and Mrs. P. Anthony Meza Elaine J. Mickelson MTU Detroit Diesel Patrick J. Parden, M.D. Allen R. Pearce Donald and Debra Puro Drs. Penporn and Stephen Reck Paul and Marilyn Rizzo

“What I’ve learned over the years is that any size gift can make an impact. A gift might help a researcher develop something that is strong enough to submit to the National Institutes of Health or some other organization for a larger grant. It’s that seed money that really counts. I have seen so many people who have been affected by macular degeneration that I would really like to see some strides made toward curing that.” — Jon B. Gandelot, President, the Edward T. and Ellen K. Dryer Charitable

Foundation, and his wife, Lisa,

a trustee of the Foundation

Dedicated to Discovery

With gratitude for gifts made from July 1, 2009, through June 30, 2010 Iva Jean Roe Drs. Michael and Mary Ruddat Stephen J. and Kim R. Saxe Helen Schaper Charles Sherman Becky and Doug Spaly John and Alexandra Starr James P. and Dorothy Symons F. Brian and Lee Talbot Thomas G. Varbedian, M.D. Andrew Vine and Caroline Blane Dr. and Mrs. Keith M. Williams The Lawrence and Sylvia Wong Foundation

$100 to $499

“I credit the physicians here with drastically improving sight in one of my eyes, and I am walking proof of the skills they have. What impresses me the most is that they are so committed to research and to solving problems. They are taking care of today, but they are looking toward tomorrow. It’s very gratifying to be a part of this institution.” — John C. Schultz, with his wife, Karen,

who are annual supporters of the

Kellogg Eye Center

Anonymous Donors (17) Cynthia Abejuro Mowafak H. Albayya Ann T. Alexander Lyle and Margaret Allis Dr. Krista Anderson Catherine Andrea Deane and Marilyn Baker Dr. and Mrs. John D. Baker Mrs. Patricia Baker Sandra and William Baker Dr. and Mrs. Shan R. Baker Mary and Thomas Ball I. Josephine Ballert Lawrence A. Barnes Harold and Robert Barron Anne and Donald F. Baty, Jr. Lois Bereza Jean W. Berkley Rhoda L. and Roger M. Berkowitz Thomas A. Bersani and Joan Christy Robert Bickley Samir and Mona Binno Salvatore Bisaccia Michael and Clarita Bishel Drs. Barbara A. Blodi and Justin L. Gottlieb Donald and Georgia Boerma Stephen Boorstein, M.D. Nicholas and Paulajean Bosch Nancy S. Boutell Daniel L. Braden William and Julie Bromley Henry J. and Jean L. Brown Dr. Margaret C. Brown Rebecca E. Brown Joanna F. Brumfiel Wilbur and Carolyn Burkett Emily Burrell Donald V. Calamia James and Geraldine Chaffers Sherry and David Chang Anne M. Chase

university of michigan kellogg eye center

Hideki and Tomomi Chuman Marilyn L. Citron John and Carolyn Clark Martha and James Cleary Louise Clements Donald L. Cole Carl and Maria Constant Patrick and Laura Coppens Wayne and Barbara Cornblath Ellen L. Coulthard MargaretAnn Cross and James Van Fleteren Richard and Margaret Cundiff Cathleen A. Curley William and Carol Cutler Arthur and Larisa Czabaniuk Dolores and Michael Czerniak Lyubica Dabich, M.D. Dorothy M. Damon Dolores D. Daudt James E. Davies Prof. William and Virginia Dawson Judi and Daniel DeMartin Jonathan Demb and Mary Best James R. Devine Prof. Norma Diamond Dr. M. Kenneth and Arvene Dickstein David J. Disser Gregory and Dottie Dootz Mr. and Mrs. Kenneth R. Dornbrook Dr. and Mrs. Richard K. Dortzbach Daniel B. Drysdale, M.D. Mrs. Jeanette R. Duckworth John S. Dunn Deborah M. Eadie Beth Ann Eisler Bita Esmaeli, M.D. Michael J. Fanola Arnold and M. Joan Feener Michael Fetters and Sayoko Moroi Jerome and Polly Finkelstein Joan and Ted Fischer Dr. Kenneth and Lisa Fox Joan Foxwell Ralph N. Funk Benjamin and Renetta Gallup Michael J. Geiss III, M.D. Jacqueline and Richard Gilbert Michael Goldbaum Anitra and Jesse Gordon Mr. Waleed K. Gosaynie Julie Gothrup and John Phillips Norman Grigsby Jenny and Richard E. Hackel Margaret and Besondy Hagen Jane Hakken Hamilton Printing Company William P. Haney, M.D. Charlotte Hanson

With gratitude for gifts made from July 1, 2009, through June 30, 2010

“Getting to know the people who are using the microscopes I contributed and appreciating what they have accomplished, it makes me feel that I have accomplished something. Now that this building is in place and the faculty is in place, we’re going to see good things come out of it.” — Leonard G. Miller, leadership donor to the Kellogg Eye Center expansion campaign, with Dorrit Jensen

Laurelynn and George Harris Dr. and Mrs. Michael S. Harris Theodore and Naomi Harrison Noriko and Dr. Ken Hashimoto Ronald and Patricia Hebert Dr. and Mrs. David Heidemann Dr. and Mrs. John W. Henderson Gerald and Mignon Heppler Steven Herman Ruth Heyn, M.D. Frederick J. Heyner Jeanne and Conrad Heyner Richard and Jane Hiss Prof. Emeritus Gerald P. Hodge Charles F. Hoitash Mary M. Howrey Martin and Catherine Huebner Bret A. and Laura Hughes Margaret M. and James E. Hughes Larry J. Hunt Shelley L. Hurt Brianna Iddings Dr. Robert S. Jampel Kathryn and Wilbur Johnson Mr. and Mrs. Kenneth B. Johnson Mark and Linda Johnson Mary P. Johnson T. Mark Johnson, M.D. Mark E. Johnston, M.D., and Elizabeth McInerney Artie Jones and Kimberly Dulimba Prof. Dallas and Irene Jones S. Preston and Betty B. Jones Jill Taft Kaufman Robert B. Kaufman, M.D. Charlene and Leo Kay

Rosemary S. Kaye Mrs. Robert M. Keil Elissa L. Kilgore Michael A. Kipp, M.D. Robert and Toby Kleinberg William L. and Betty G. Knapp Mary Jo Knight Frank J. Konkel Theodore and Caroline Korn Drs. Teresa and Norman Krieger Sam and Marilyn Krimm Jennifer E. Kromrei Susan and James Krucki Gerald and Dorothy Kurtz Leonard J. Lachance Marie Lane Louis and Gail LaRiche Kurt K. Lark, M.D. David and Muriel Learned Lucille Lefler Mr. and Mrs. F. R. Lehman Gary Lelli and Kelly Bottger Cheryl L. and J. Paul Lemieux Jeanne M. Lerchen Bobbie and Myron Levine John C. Lillo Sherry L. Lindahl Mark and Carol Loessel Lonnie L. Loy Caroline MacDonald Angelo Maeso Lisa Maletic Lucille A. Malloure Steven Manikas Richard and Barbara Mannis Karen and Bob Martin

Taliva Martin, M.D. Mr. and Mrs. Terence L. McDaniel Judy and A.J. McDonald Virginia and Wilbert McKeachie Lloyd and Helen McKee Margaret McKinley and Dan Ketelaar Donald and Diane Meitz Carolyn E. Mesara Robert and Margery Mesler Herbert and Carolyn Metzger Laurie and Fredrick Metzger Charles and Kathleen Meyer Helen L. Mitchell Ms. Marlene M. Moleski Eugene and Barbara Moore Richard G. Mosteller Joseph and Alice Mottillo William J. Mundus Alphonsus and Ann Murphy David C. and Janice E. Musch Dr. Michel and Alice Nasif Diana and Robert Nast Catherine E. Nesbitt Jonathon P. Niemczak Betsy and Ken Nisbet Harry and Leeta Nistel Northport Lions Club Omondi L. Nyong’o, M.D. Michael and Jessica Ober Kenneth E. Oettle John Orr Constance and David Osler Mohammad I. and J. Elizabeth Othman Kishan Padakannaya John Papajohn

Dedicated to Discovery

With gratitude for gifts made from July 1, 2009, through June 30, 2010 Joseph and Betty Pavka Therese Pena Terry McKenney Person Donald and Dorothy Peterson Susan and Joseph Piangozza Barry S. Pinchoff, M.D. Sheryl and Douglas Podlewski Rebecca and Eric Priebe Drs. Douglas J. and Leslie E. Quint Jill and Eric Ray Venkat and Alvira Reddy Mr. and Mrs. Walter F. Redmond Ann M. Reed Robert O. Reisig, M.D. Charles S. Remenar Rita and Robert Reske Mr. and Mrs. Robert L. Richardson, Jr. Jeryl and John Wallace Risk Barbara and Art Rocco Horace and Yvonne Rodgers Dennis A. and Olivia S. Ross Rennie and Michael Roth Jonathan A. and Robin L. Rowe Clifton D. Rowland Mr. and Mrs. James C. Rucker Mr. Francis A. Sailer Loretta D. Sammet Warren and Nancy Scherer Charles R. Schmitter, Jr., M.D., and Allyn C. Ravitz Judith A. and Willard L. Schneider Eileen Schott John and Karen Schultz Lisbeth and Douglas Schwab Frances C. Scott Yamini Sebihi Ardith and Claude Sebring

Ruth I. Segura Joseph and Nancy Shore Kathleen A. Silverman James and Doris Sisson Kenneth S. Smith Sue-Ellen Smith Herbert Snitz State Farm Companies Foundation Virginia and Eric Stein Thomas and Jane Stratford Louise A. Strong-Vassau Joel Sugar and Anita Gerber John and Joan Tedford Dewey Tennent Edward and Karen Tenner Anna Belle R. Thomas Elaine J. Thompson E. J. Valley Ralph and Charlotte VanDerBos B. Craig Vrooman and Laura Dykstra Claudia M. Wagner David R. Wagner Randall S. and William K. Wallach Lee S. Webster Carol and Jack Weigel Carolyn Jean Weigle Cyrus R. Welman Dr. and Mrs. William W. Wells Avis L. White Margaret B. White Dr. Patrick T. and Mary White David and Phyllis Wittrock Ted and Lynda S. Wojno Alberta and Lloyd Wolfe Ford L. Wright Rebecca Wu, M.D. and Michael Mendez

Michael and Kathleen Yang Gloria Yff Harry and Miriam Yukelson Henry and Dorothy Zelisse Jeff and Kate Zink Wanda Zissis W. Tom and Helen ZurSchmiede, Jr.

In Memory Of The Kellogg Eye Center is honored to have received gifts in memory of the following individuals. Matthew Alpern, Ph.D. Peggy Baier Norbert Bereza Sandra Bessert Idelle Binder Edmund Brownell George Carter Ada Ruth Childers Ruth F. Clarke Birdie Cooper Clarence Damon Marie Doran Durell Dressler Harold H. Dye Betty Fagin Harold F. Falls, M.D. Marvin Fox F. Bruce Fralick, M.D. Bartley Frueh, M.D. Henry Gray, Ph.D. Yamina Imloue Steve Kaufman Robert Keil

“I love the Kellogg Eye Center. I’ve loved it for 52-and-a-half years. I am honored to work with all of the faculty members here, and Dr. Paul Lichter is a wonderful leader. He believes so much in research and advancement, and it shows. This new tower will have a very big influence. It’s going to mean an awful lot to our clinics and to our research.” — Ida L. Iacobucci, C.O., Associate Professor, Ophthalmology and Visual Sciences

university of michigan kellogg eye center

With gratitude for gifts made from July 1, 2009, through June 30, 2010 Betty Lachance Tom Lacy Susan Lichter Theodore Massenberg, Jr. Marvin Joe McKenney Dr. Agnes C. McMenemy Roland J. Morey Joan Oliver Stuart W. Porter Richard Priebe Carl Roe Arlene Rood Frank W. Sassaman, M.D. Earl L. Schaper William Selezinka, M.D. Mary Shaughnessy Charles L. Smith, M.D. Lillian Taylor Marilyn Varbedian Judge Thaddeus N. Walinski Lillian E. Weigle Holland Wesley Jean Wilson Thomas Wright, M.D. Mrs. Allan C. Zander

In Honor Of The following individuals were honored through gifts to the Kellogg Eye Center. Anthony P. Adamis, M.D. Terry J. Bergstrom, M.D. Mary Ann Brandt Michele Burke Paul and Kate Coleman Paul H. Drews Mr. and Mrs. Jay W. Dull Dr. and Mrs. Ernest L. Dunn Mrs. Jane G. Elliott Robert Goyer David H. Grossman Jerome Grossman John W. Henderson, M.D., Ph.D. Mark W. Johnson, M.D. Katelyn Kelleher Kellogg Eye Center Researchers Paul R. Lichter, M.D. Shahzad I. Mian, M.D. Sayoko E. Moroi, M.D., Ph.D. Christine C. Nelson, M.D. Michael Roth, M.D. Stephen J. Saxe, M.D. Chelsea Short Michael W. Smith-Wheelock, M.D. H. Kaz Soong, M.D. Carol L. Standardi, R.N. Alan Sugar, M.D.

Walter R. Szezur Marian Thompson Susan S. Thoms, M.D. Jonathan D. Trobe, M.D. Clare Van Fleteren Andrew K. Vine, M.D. Thomas and Margaret Waugh Evelyn Wiacek Dr. George J. Zissis

Bequests and Other Planned Gifts It is with deep gratitude that we recognize the following individuals for making the Kellogg Eye Center a part of their estate plans. Frank J. and Helga Arnold Nancy Bender Anne S. Benninghoff Rhoda L. and Roger M. Berkowitz Robert D. Biggs, M.D. Ruth F. Clarke Gloria P. and William E. Dean, Jr. Ralph M. Fox Helen A. (Poorbaugh) Freedman Larry and Mary Gerbens Conrad L. Giles Ed and Sue Gorney Ida Lucy Iacobucci Mrs. Harry Krashen Edward and Duffy Ladenberger Harry and Eva McGee Marvin Joe and Beverly McKenney Bruce L. and Roberta Oliver Sally J. Pryce Mrs. Shirley M. Schaible William Selezinka, M.D. E.H. Newel and Rosemary Smith Russell A. Stephens and Phyllis A. Capogna James B. Thompson and Mary Ann Brandt David and Jayne VerLee Michael A. Wainstock, M.D. Jean A. and Richard C. Wilson

Only those who gave their permission are included above.

“My husband gave the first donation to the new Eye Center more than 10 years ago, and as the years went on we continued to give what we could. We are very honored to have the privilege to donate to this fine facility. It is just an awesome place, and the research that goes on here is really exciting. I can’t believe that it’s been 25 years since the first tower went up. In 25 years, I hope my grandchildren will be back to donate.” — Mary June Wilkinson, whose husband, William, and son, W. Scott Wilkinson,

completed their ophthalmology training

at the University of Michigan

The Kellogg Eye Center greatly values our donors, and we make every effort to ensure the honor roll is accurate. Please call us at 734.615.0243 if you note any errors.

Dedicated to Discovery

Faculty honors, recognition, and publications Steven M. Archer, M.D. Awards/Honors/Leadership • Best Doctors in America • Director and host, 2010 Squint Club Annual Meeting Publications Pérez G, Archer SM, Artal P. Optical characterization of Bangerter foils. Invest Ophthalmol Vis Sci 2010;51:609-613. Bothun ED, Johnson CS, Archer SM, Del Monte MA. Evolution of postoperative astigmatism after large incision PMMA lens implantation in children. J AAPOS 2010 [in press]. Outreach and Public Service • Visiting Faculty, World Eye Mission, Trujillo, Peru

Terry J. Bergstrom, M.D. Grants See grants, page 55

Grant M. Comer, M.D. Grants See grants, page 55 Awards/Honors/Leadership • Edward T. and Ellen K. Dryer Career Development Professor of Ophthalmology and Visual Sciences • Editor, Ocular melanoma and retinal vein occlusions. Eye Wiki. American Academy of Ophthalmology • Reviewer, Ophthalmology • Reviewer, Retina • Reviewer, Eye

Theresa M. Cooney, M.D. Awards/Honors/Leadership • Representative of the Michigan Society of Eye Physicians and Surgeons to the Michigan State Medical Society Publications Parker J, Tandon A, Shtein RM, Cooney TM, Musch DC, Soong KH, Sugar A, Mian SI. Management of pain with diclofenac after LASIK with femtosecond laser. J Cataract Refract Surg 2010 (in press). Mian SI, Cooney T, Sugar A. Cornea. In: Gold DH, Lewis RA, eds. Clinical Eye Atlas, 2nd ed., Chicago:AMA Press 2010 [in press].

Wayne T. Cornblath, M.D. Grants See grants, page 55 Awards/Honors/Leadership • Best Doctors in America • Visiting Professor, University of Maryland 46

• Moderator: Breakfast with the Experts; Unexplained visual loss. American Academy of Ophthalmology Annual Meeting • Moderator: Top Ten Neuro-ophthalmic Diagnoses You Don’t Want to Miss. American Academy of Ophthalmology Annual Meeting • Moderator: The Distinguishing Ocular Motility Finding in “Wait, Wait … Don’t Tell Me”: Recognizing distinguishing signs in neuro-ophthalmology. North American Neuro-Ophthalmology Society. American Academy of Ophthalmology Annual Meeting • Director: Top Ten Neuro-ophthalmic Diagnoses You Can’t Afford to Miss. American Academy of Neurology Annual Meeting • Editorial Board, Frontiers in Ophthalmology • Editorial Board, Up-To-Date • Member, Scientific Program Subcommittee of the Education Committee, North American Neuro-Ophthalmology Society • Member, Education Liaison Committee, American Academy of Ophthalmology Publications Optic Neuritis Study Group. Visual field profile of optic neuritis: A final follow-up report from the Optic Neuritis Treatment Trial from baseline through 15 years. Arch Ophthalmol 2010;128:330-337.

Sherry H. Day, O.D. Awards/Honors/Leadership • Invited speaker, National Foundation for the Blind, Midwest Chapter Outreach and Public Service • Guest speaker on low vision, Vision 2010, Washtenaw Community College

Monte A. Del Monte, M.D. Awards/Honors/Leadership • Best Doctors in America • Keynote Speaker in Pediatric Ophthalmology, XXIX Congress of Ophthalmology of the Mexican Society of Ophthalmology, Monterrey, Mexico • 25th Annual Roger Johnson Lecturer, Seattle Children’s Hospital, University of Washington • Special Visiting Professor and Commissioned Trainer for Combined Ophthalmology Programs in Hong Kong • Keynote Speaker, International Summit for Strabismus and Pediatric Ophthalmology, Shanghai, China • Keynote Speaker, Pediatric Ophthalmology and Strabismus Symposium, Sino-Japan Ophthalmology Symposium, Tianjin International Ophthalmology Forum 2010, Tianjin, China

university of michigan kellogg eye center

• Member, Scientific Advisory Committee, Knight’s Templar Eye Research Foundation • Chairman, International Affairs Committee, American Association for Pediatric Ophthalmology and Strabismus • Member, Council of Chairs, American Association for Pediatric Ophthalmology and Strabismus Publications Weng CY, Kothary PC, Verkade AJ, Reed DM, Del Monte MA. MAP kinase pathway is involved in IGF-1-stimulated proliferation of human retinal pigment epithelial cells. Curr Eye Res 2009;34:867-876. Del Monte MA. Sturge Weber Syndrome. emedicine.com, vol. 9, 2009. Del Monte MA. Surgical treatment of residual accommodative esotropia. In: Ocular Potpourri, Audio-Digest Ophthalmology, 2010;48:13 (July 7). Kothary PC, Badhwar J, Weng C, Del Monte MA. Impaired intracellular signaling may allow up-regulation of CTGF-synthesis and secondary peri-retinal fibrosis in human retinal pigment epithelial cells from patients with age-related macular degeneration. In: Hollyfield JG, Anderson RE, Lavail MM, eds., Advances in Experimental Medicine and Biology/Retinal Degenerative Diseases. New York:Springer 2010;664:419-428. Enzenauer R, Del Monte MA. Strabismus. In: Rudolph C, Lister G, Gershon A, First L, Rudolph A, eds. Rudolph’s Pediatrics, 22nd ed. New York:McGraw-Hill 2010 [in press]. Del Monte MA. Ocular anatomy and physiology. In: Rudolph C, Lister G, Gershon A, First L, Rudolph A, eds. Rudolph’s Pediatrics, 22nd ed. New York:McGraw-Hill 2010 [in press]. Bothun ED, Johnson CS, Archer SM, Del Monte MA. Evolution of postoperative astigmatism after large incision PMMA lens implantation in children. J AAPOS 2010 [in press].

Jonathan B. Demb, Ph.D. Grants See grants, page 55 Awards/Honors/Leadership • Invited speaker, NEI 40th Anniversary Symposium on Neuroscience and Vision, NIH • Invited speaker, Yale University School of Medicine, Dept. of Ophthalmology & Visual Science • Invited speaker, Jefferson Medical College, Department of Neuroscience • Invited speaker, 13th Annual Vision Research Conference, Ft. Lauderdale • Invited speaker, FASEB: Retinal Neurobiology and Visual Processing

Faculty honors, recognition, and publications • Keynote speaker, International Myopia Conference, Tuebingen • Associate Editor, Journal of Neuroscience • Ad-Hoc Reviewer, NIH Study Section (Biology and Diseases of the Posterior Eye) Publications Manookin M, Demb JB. Information processing: contrast sensitivity. In: Encyclopedia of the Eye, Vol. 2. Darlene A. Dartt, ed. Oxford:Academic Press, 2009, pp 344-348. Manookin MB, Weick M, Stafford BK, Demb JB. NMDA receptor contributions to visual contrast coding. Neuron 2010;67:280-293. Demb JB. Retina: microcircuits for daylight, twilight and starlight. In: Handbook of Brain Microcircuits. Shepherd G, Grillner S, eds. New York:Oxford University Press, 2010 [in press].

Raymond S. Douglas, M.D., Ph.D. Grants See grants, page 55 Awards/Honors/Leadership • Invited speaker, American Thyroid Association Annual Meeting, Palm Beach, FL • Invited speaker, Graves’ Disease Foundation, Graves’ Disease Patient & Family Education Conference, Charlotte, NC • Invited speaker, International Thyroid Eye Disease Society Meeting, San Francisco, CA Publications Douglas RS, Tsirbas A, Gordon M, Lee D, Khadavi N, Garneau HC, Goldberg RA, Cahill K, Dolman PJ, Elner V, Feldon S, Lucarelli M, Uddin J, Kazim M, Smith TJ, Khanna D. Development of criteria for evaluating clinical response in thyroid eye disease using a modified Delphi technique. Arch Ophthalmol 2009;127:1155-1160. Khadavi NM, Mancini R, Nakra T, Tsirbas AC, Douglas RS, Goldberg RA, Duckwiler GR. Rare dural arteriovenous fistula of the lesser sphenoid wing sinus. Ophthal Plast Reconstr Surg 2009;25:404-406. Khanna D, Chong KL, Afifiyan HF, Hwang CJ, Lee DK, Garneau HC, Goldberg RA, Darwin CH, Smith TJ, Douglas RS. Rituximab treatment of patients with severe, corticosteroidresistant thyroid-associated ophthalmopathy. Ophthalmology 2010;117:179-186. Douglas RS, Affiyan NF, Hwang CJ, Chong K, Haider U, Richards P, Gianoukakis AG, Smith TJ. Increased generation of fibrocytes in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 2010;95:430-438. Naik VM, Naik MN, Goldberg RA, Smith TJ, Douglas RS. Immunopathogenesis of thyroid eye disease: emerging paradigms. Surv Ophthalmol 2010;55:215-226.

Lee S, Taban M, Chong KL, Goldberg RA, Douglas RS. Endoscopic removal of nasoglabellar dermoid cysts. Ophthal Plast Reconstr Surg 2010;26:136-139. Taban M, Nara T, Hwang C, Hoenig JA, Douglas RS, Shorr N, Goldberg RA. Aesthetic lateral canthoplasty. Ophthal Plast Reconstr Surg 2010;26:190-194. Janez L, Taban M, Wong C-A, Ranganath K, Douglas RS, Goldberg RA. Localized intraorbital Castleman’s Disease: a case report. Orbit 2010;29:158-160. Hegedus L, Smith TJ, Douglas RS, Nielsen CH. Targeted biological therapies for Graves’ disease and thyroid associated ophthalmopathy. Focus on B cell depletion with Rituximab. Clin Endocrinol 2010 [in press]. Chang HS, Lee D, Taban M, Douglas RS, Goldberg RA. “En-Glove” lysis of lower eyelid retractors with AlloDerm and dermisfat grafts in lower eyelid retraction surgery. Ophthal Plast Reconstr Surg 2010 [in press]. Yen MT, Hwang, C, Goldberg RA, Douglas RS. Surgery of the Eyelids, Orbit, and Lacrimal System (Ophthalmology Monographs; 8, 2nd ed.) New York:Oxford University Press, 2010 [in press].

Susan G. Elner, M.D. Grants See grants, page 55 Awards/Honors/Leadership • Best Doctors in America • Executive Editor, American Journal of Ophthalmology • Director, Vitreoretinal fellowship program, University of Michigan Kellogg Eye Center Publications Bian ZM, Elner SG, Elner VM. Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2009;50:6006-6014. Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Nathan DM, Zinman B, Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ. Modernday clinical course of type 1 diabetes mellitus after 30 years’ duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med 2009;169:1307-1316.

Ip MS, Scott IU, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M, Singerman LJ, Tolentino M, Chan CK, Gonzalez VH; SCORE Study Research Group. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to CRVO: the standard care vs corticosteroids for retinal vein occlusion (SCORE) study report 5. Arch Ophthalmol 2009;127:1101-14; Erratum: Arch Ophthalmol 2009;127:1648. Scott IU, Ip MS, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M, Chan CK, Gonzalez VH, Singerman LJ, Tolentino M; SCORE Study Research Group. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular edema secondary to BRVO: the standard care vs corticosteroids for retinal vein occlusion (SCORE) study report 6. Arch Ophthalmol 2009;127:1115-28; Erratum: Arch Ophthalmol 2009;127:1655. Scott IU, Oden NL, VanVeldhuisen PC, Ip MS, Blodi BA, Antonszyk AN; SCORE Study Investigator Group. SCORE Study Report 7: incidence of intravitreal silicone oil droplets associated with staked-on vs luer cone syringe design. Am J Ophthalmol 2009;148:725-732. Yang D, Elner SG, Lin L-R, Reddy VN, Petty HR, Elner VM. Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci 2009;50:4998-5005. Demirci H, Elner SG, Elner VM. Rigid nylon foil-anchored polytetrafluoroetyhlene (Gor-Tex) sheet stenting for conjunctival fornix reconstruction. Ophthalmology 2010;117:1736-1742.

Victor M. Elner, M.D., Ph.D. Grants See grants, page 55 Awards/Honors/Leadership • Best Doctors in America • Member, Committee for Ocular Tumors, Pathology and Orbit, Lacrimal Plastic Surgery • Member, Awards Committee, American Society of Ophthalmic Plastic and Reconstructive Surgery • Board of Directors: International Thyroid Eye Disease Society Publications Bian ZM, Elner SG, Elner VM. Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2009;50:6006-6014.

Dedicated to Discovery

Faculty honors, recognition, and publications Douglas RS, Tsirbas A, Gordon M, Lee D, Khadavi N, Garneau HC, Goldberg RA, Smith TJ, Cahill K, Dolman P, Elner V, Feldon S, Lucarelli M, Uddin J, Kazim M, Khannar D. Development of criteria for evaluating clinical response in thyroid eye disease (CRI-TED) using a modified Delphi technique. Arch Ophthalmol 2009;127:1155-1160. Field MG, Elner VM, Feuerman JM, Heckenlively JR, Petty HR. In Reply. Arch Ophthalmol 2009;127:943-944. Yang D, Elner SG, Lin L-R, Reddy VN, Petty HR, Elner VM. Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci 2009;50:4998-5005. Koreen IV, Flint A, Nelson CC, Frueh BR, Elner VM. Non-diagnostic conjunctival map biopsies for sebaceous carcinoma. Arch Ophthalmol 2009;127:961-963. Feuerman JM, Flint A, Elner VM. Cystic solitary fibrous tumor of the orbit. Arch Ophthalmol 2010;128:385-387. Shtein RM, Elner VM. Herpes simplex virus keratitis: histopathology and corneal allograft outcomes. Expert Rev Ophthalmol 2010;5:129-134. Petty HR, Elner VM, Kawaji T, Clark AJ, Thompson D, Yang D. A facile method for immunofluorescence microscopy of highly autofluorescent human retinal sections using nanoparticles with large Stokes shifts. J Neurosci Methods 2010;191;222-226. Demirci H, Elner SG, Elner VM. Rigid nylon foil-anchored polytetrafluoroetyhlene (Gor-Tex) sheet stenting for conjunctival fornix reconstruction. Ophthalmology 2010;117:1736-1742. Cho RI, Elner VM. Closure of mid-posterior Tenon’s capsule in enucleation. Ophthal Plast Reconstr Surg 2010 [in press]. Choe CH, Cho RI, Elner VM. Comparison of lateral and medial orbital decompression for the treatment of compressive optic neuropathy in thyroid eye disease. Ophthal Plast Reconstr Surg 2010 [in press]. Shtein RM, Newton DW, Elner VM. Actinomyces infectious crystalline keratopathy. Arch Ophthalmol 2010 [in press].

Jerome I. Finkelstein, M.D., FACS Awards/Honors/Leadership • Best Doctors in America • Invited Speaker, 46th Annual Northern Michigan Summer Conference: Update on Common Clinical Concerns in Primary Care

Bruce A. Furr, C.O., M.S.P.H. Awards/Honors/Leadership • President, American Association of Certified Orthoptists • Member, Executive Committee, American Orthoptic Council • Elected to Canadian Orthoptic Council • Co-host, American Academy of Ophthalmology/American Orthoptic Council/American Association of Certified Orthoptists Strabismus Symposium, AAO Annual Meeting

Philip J. Gage, Ph.D. Grants See grants, page 55 Publications Acharya M, Lingenfelter DJ, Huang L, Gage PJ, Walter MA. Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells. J Biol Chem 2009;284:3482934838. Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA. AP-2a knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet 2010;19:1791-1804. Zacharias AL, Gage PJ. Canonical Wnt/ßcatenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. Dev Dynamics 2010 [in press].

Richard E. Hackel, C.R.A. Awards/Honors/Leadership • Member, Board of Education, Ophthalmic Photographers’ Society • Editorial Board, Journal of Ophthalmic Photography • Editorial Board, Journal of Neuro Ophthalmology Publications Contributing author [photographs]: The Retina Atlas, Lawrence Yannuzzi, Saunders/ Elsevier, 2010. Koreen L, He S, Johnson MW, Hackel R, Khan N, Heckenlively JR. Anti-retinal pigment epithelium antibodies in acute exudative polymorphous vitelliform maculopathy: A new hypothesis about disease pathogenesis. Arch Ophthalmol 2010 (in press).

John R. Heckenlively, M.D. Grants See grants, page 55 Awards/Honors/Leadership • Best Doctors in America • Editorial Board, Eye

university of michigan kellogg eye center

• Reviewer, Study Section R24, National Eye Institute, NIH Publications Chang B, Grau T, Dangel S, Hurd R, Jurklies B, Sener EC, Andreasson S, Dollfus H, Baumann B, Bolz S, Artemyev N, Kohl S, Heckenlively J, Wissinger B. A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6 gene. Proc Natl Acad Sci U S A 2009;106(46):19581-19586. Lu Y, Jia L, He S, Hurley, Leys MJ, Jayasundera T, Heckenlively JR. Melanomaassociated retinopathy. A paraneoplastic autoimmune complication. Arch Ophthalmol 2009;127:1572-1580. Chen W, Stambolian D, Edwards AO, et al. Genetic variants near TIMP3 and highdensity lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A 2010;107(16):7401-7406. Heckenlively JR, Ferreyra HA, Jayasundera T. Controversies of diagnosing autoimmune retinopathy. Arch Ophthalmol 2010;128:147148. Lu Y, He S, Jia L, Khan NW, Heckenlively JR. Two mouse models for recoverin-associated autoimmune retinopathy. Mol Vis 2010;16:1935-1947. Wu DM, Khanna H, Atmaca-Sonmez P, Sieving PA, Branham K, Othman M, Swaroop A, Daiger SP, Heckenlively JR. Long-term followup of a family with dominant-linked retinitis pigmentosa. Eye 2010;24:764-774. Daiger SP, Sullivan LS, Bowne SJ, Birch DG, Heckenlively JR, Pierce EA, Weinstock GM. Targeted high-throughput DNA sequencing for gene discovery in retinitis pigmentosa. Adv Exp Med Biol 2010;664:325-331. Jayasundera T, Rhoades W, Branham K, Niziol LM, Musch DC, Heckenlively JR. Peripapillary dark choroid ring as a helpful diagnostic sign in advanced Stargardt disease. Am J Ophthalmol 2010;149:656-660. Jayasundera T, Branham KE, Othman M, Rhoades WE, Karoukis AJ, Khanna H, Swaroop A, Heckenlively JR. RP2 phenotype and pathogenetic correlations in X-linked retinitis pigmentosa. Arch Ophthalmol 2010;128:915-922. Friedman JS, Chang B, Krauth DS, Lopez I, Waseem NH, Hurd RE, Feathers KL, Branham KE, Shaw M, Thomas GE, Brooks MJ, Liu C, Bakeri HA, Campos MM, Maubaret C, Webster AR, Rodriguez IR, Thompson DA, Bhattacharya SS, Koenekoop RK, Heckenlively JR, Swaroop A. Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice. Proc Natl Acad Sci U S A. 2010;107(35):15523-15528.

Faculty honors, recognition, and publications Koreen L, He S, Johnson MW, Hackel R, Khan N, Heckenlively JR. Anti-retinal pigment epithelium antibodies in acute exudative polymorphous vitelliform maculopathy: A new hypothesis about disease pathogenesis. Arch Ophthalmol 2010 (in press). Yao J, Feathers KL, Khanna H, Thompson DA, Tsilfidis C, Hauswirth WW, Heckenlively JR, Swaroop A, Zacks DN. XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina. Invest Ophthalmol Vis Sci 2010 [in press].

Peter F. Hitchcock, Ph.D. Grants See grants, page 55 Awards/Honors/Leadership • Director (founding), University of Michigan Medical School Office of Postdoctoral Studies • Member, Executive Board, Rackham School of Graduate Studies, University of Michigan • Member, Advisory Committee, University of Michigan Medical School Biomedical Cores Research Facilities • Member, University of Michigan Medical School Basic Sciences Academic Review Board • Editorial Board, Journal of Ocular Biology, Diseases and Informatics Publications Calinescu A-A, Raymond PA, Hitchcock PF. Midkine expression is regulated by the circadian clock in the retina of the zebrafish. Vis Neurosci 2009;26:495-501. Ghosh AK, Murga-Zamalloa CA, Chan L, Hitchcock PF, Swaroop A, Khanna H. Human retinopathy-associated ciliary protein retinitis pigmentosa GTPase regulator mediates ciliadependent vertebrate develoment. Hum Mol Genet 2009;19:90-98. Craig SEL, Thummel R, Ahmed H, Vasta GR, Hyde DR, Hitchcock PF. The zebrafish galectin Drgal1-L2 is expressed by proliferating Müller glia and photoreceptor progenitors and regulates the regeneration of rod photoreceptors. Invest Ophthalmol Vis Sci 2010 [in press].

Bret A. Hughes, Ph.D. Grants See grants, page 56 Awards/Honors/Leadership • Member, Special Emphasis Panel, National Eye Institute, NIH • Director, University of Michigan Core Center for Vision Research

Publications Pattnaik B, Hughes BA. Regulation of Kir Channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate. Am J Physiol Cell Physiol 2009;297:C1001-1011.

The Score Study Research Group. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion. SCORE study report 5. Arch Ophthalmol 2009;127:1101-1114.

Denise A. John, M.D., FRCSC

The Score Study Research Group. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular edema secondary to branch retinal vein occlusion. SCORE study report 6. Arch Ophthalmol 2009;127:1115-1128.

Awards/Honors/Leadership • Chief, Ophthalmology Service, Veterans Administration Medical Center, Ann Arbor, MI • Assistant Director, Ophthalmology and Visual Sciences Residency Program, University of Michigan Publications John DA. Management of intraocular foreign bodies, EyeNet, Sept 2009. Outreach and Public Service • Glaucoma screening with medical students, University of Michigan Medical School • Glaucoma screening with medical students, Parkridge Community Center, Ypsilanti, MI

Mark W. Johnson, M.D. Grants See grants, page 56 Awards/Honors/Leadership • Best Doctors in America • Guide to America’s Top Ophthalmologists • Silver Fellow, Association for Research in Vision and Ophthalmology • Elected to membership, Gass Fluorescein Club • Member, Periodic Ophthalmic Review Tests Panel, American Board of Ophthalmology • Chairperson, Nominating Committee, Macula Society • Member, Data and Safety Monitoring Committee: Comparison of Age-related Macular Degeneration Treatments Trials, National Eye Institute, NIH • Member, Data and Safety Monitoring Committee: Clinical Trial of Stereotactic Radiotherapy for Exudative AMD and Clinical Trial of Combined Anti-PDGF and Anti-VEGF Therapy • Editorial Board, American Journal of Ophthalmology • Editorial Board, Retina • Editorial Board, Retinal Physician • Member, Committee on Programs, American Ophthalmological Society • Secretary, The Retina Society Publications Ip MS, Oden NL, Scott IU, et al., and the SCORE Study Investigator Group. SCORE study report 3: Study design and baseline characteristics. Ophthalmology 2009;116:1770-1777.

Scott IU, Oden NL, VanVeldhuisen PC, Ip MS, Blodi BA, Antoszyk AN and the The Score Study Investigator Group. SCORE Study report 7: Incidence of intravitreal silicone oil droplets associated with staked-on vs luer cone syringe design. Am J Ophthalmol 2009;148:725-732. Domalpally A, Blodi BA, Scott IU, Ip MS, Oden NL, Lauer AK, VanVeldhuisen PC and the SCORE Study Investigator Group. The standard care vs corticosteroid for retinal vein occlusion (SCORE) study system for evaluation of optical coherence tomograms: SCORE Study Report 4. Arch Ophthalmol 2009;127:1461-1467. Chong DY, Johnson MW, Shen D, Chan CC, Callanan DG. Vitreous metastases of primary cutaneous B-cell lymphoma. Ocul Immunol Inflamm 2009;17:342-344. Johnson MW. Posterior vitreous detachment: Evolution and complications of its early stages (Perspective). Am J Ophthalmol 2010;149:371-382. Koreen L, He S, Johnson MW, Hackel R, Khan N, Heckenlively JR. Anti-retinal pigment epithelium antibodies in acute exudative polymorphous vitelliform maculopathy: A new hypothesis about disease pathogenesis. Arch Ophthalmol 2010 (in press). Regillo C, Holekamp N, Johnson MW, Kaiser PK, Schubert H, Schmidt-Efurth U, Spaide R. Retina and Vitreous (Section 12). Basic and Clinical Science Course. American Academy of Ophthalmology, 2009-2010.

Alon Kahana, M.D., Ph.D. Grants See grants, page 56 Awards/Honors/Leadership • Best Doctors in America • Career Development Award recipient, Research to Prevent Blindness • ARVO/Alcon Early Career Clinician Scientist Research Award • Invited speaker, American Academy of Ophthalmology Annual Meeting • Member, University of Michigan Center for Organogenesis Dedicated to Discovery

Faculty honors, recognition, and publications • Visiting Professor, Hadassah Medical Center, Ein Kerem, Israel • Invited Speaker, Gordon Research Conference, Il Ciocco, Barga, Italy • Invited Speaker, Israel Oculoplastics Conference, Tel-Aviv, Israel Publications Kahana A, Bohnsack BL, Cho RI, Maher C. Subtotal excision with adjunctive sclerosing therapy for the treatment of severe symptomatic orbital lymphangiomas. Arch Ophthalmol 2010 [in press].

Naheed W. Khan, Ph.D. Awards/Honors/Leadership • Reviewer, Archives of Ophthalmology • Reviewer, Journal of Ophthalmology Publications Vasireddy V, Jablonski MM, Khan NW, Wang XF, Sahu P, Sparrow JR, Ayyagari R. Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin. Exp Eye Res 2009;89:905-912.

Paul E, Kielbasinski M, Sedivy JM, MurgaZamalloa C, Khanna H, Klysik JE. Widespread expression of the Supv3L1 mitochondrial RNA helicase in the house. Transgenic Res 2010;19:691-701. Jayasundera T, Branham KE, Othman M, Rhoades WE, Karoukis AJ, Khanna H, Swaroop A, Heckenlively JR. RP2 phenotype and pathogenetic correlations in X-linked retinitis pigmentosa. Arch Ophthalmol 2010;128:915-922. Wu DM, Khanna H, Atmaca-Sonmez P, Sieving PA, Branham K, Othman M, Swaroop A, Daiger SP, Heckenlively JR. Long-term follow-up of a family with dominant-linked retinitis pigmentosa. Eye 2010;24:764-774. Yao J, Feathers KL, Khanna H, Thompson DA, Tsilfidis C, Hauswirth WW, Heckenlively JR, Swaroop A, Zacks DN. XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina. Invest Ophthalmol Vis Sci 2010 [in press].

Helios T. Leung, Ph.D., O.D., FAAO

Lu Y, He S, Jia L, Khan NW, Heckenlively JR. Two mouse models for recoverin-associated autoimmune retinopathy. Mol Vis 2010;16:1935-1947.

Outreach and Public Service • Volunteer, Remote Area Medical. Weekend clinic, Maryville, TN

Koreen L, He S, Johnson MW, Hackel R, Khan NW, Heckenlively JR. Anti-retinal pigment epithelium antibodies in acute exudative polymorphous vitelliform maculopathy: a new hypothesis about disease pathogenesis. Arch Ophthalmol 2010 [in press].

Paul R. Lichter, M.D., FACS

Hemant Khanna, Ph.D. Grants See grants, page 56 Awards/Honors/Leadership • Editorial Board, Molecular Vision • Associate Editor, BMC Ophthalmology Publications Murga-Zamalloa CA, Swaroop A, Khanna H. RPGR-containing protein complexes in syndromic and non-syndromic retinal degeneration due to ciliary dysfunction. J Genet 2009;88:399-407. Ghosh AK, Murga-Zamalloa CA, Chan L, Hitchcock PF, Swaroop A, Khanna H. Human retinopathy-associated ciliary protein retinitis pigmentosa GTPase regulator mediates ciliadependent vertebrate develoment. Hum Mol Genet 2009;19:90-98. O’Toole JF, Liu Y, Davis EE, et al. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest 2010;120:791-802. Erratum: J Clin Invest 2010;120:1362.

Grants See grants, page 56 Awards/Honors/Leadership • Best Doctors in America • Associate Editor, American Journal of Ophthalmology • President, Academia Ophthalmologica Internationalis • Trustee, Heed Ophthalmic Foundation • Walter J. Stark Memorial Lectureship, University of Oklahoma • Chair, Conflict of Interest Group, University of Michigan Medical School Publications Stein JD, Newman-Casey PA, Niziol LM, Gillespie BW, Lichter PR, Musch DC. Association between the use of glaucoma medications and mortality. Arch Ophthalmol 2010;128:235-240.

Shahzad I. Mian, M.D. Grants See grants, page 56 Awards/Honors/Leadership • Best Doctors in America • Board of Directors, Midwest Eye Bank • Editor, “Cornea,” Ophthalmic News and Education Network, American Academy of Ophthalmology Publications Mian SI, Li AY, Dutta S, Musch DC, Shtein RM. Dry eyes and corneal sensation after LASIK with the IntraLase® femtosecond laser: Effect of hinge position, hinge angle, and flap thickness. J Cataract Refract Surg 2009;35:2092-2098. Schneider E, Mian SI. Recommended practices for femtosecond laser in refractive surgery. Insight 2009;34:8-12. Mian SI, Malta JB. Moraxella keratitis: risk factors, presentation, and management. Acta Ophthalmol 2009, Nov 20. Malta J, Ahmad F, Mian S, Sugar A. Corneal inflammatory disorders. In: Trattler W, Majmudar P, Luchs J, Swartz T, eds. Cornea Handbook. Thorofare, NJ:Slack Inc, 2010, pp. 37-60. Mian S, Sugar A. Corneal complications after intraocular surgery. In: Krachmer J, Mannis M, Holland E, eds. Cornea, 3rd ed, London:Elsevier Mosby, 2010. Kamyar R, Mian SI. Femtosecond laser-assisted surgery in ophthalmology. Ophthalmol International Spring 2010:45-48. Malta JB, Sugar A, Soong HK, Musch DC, Mian SI. Ocular graft vs host disease prophylaxis with topical cyclosporine. Cornea 2010 (in press). Mian SI, Cooney T, Sugar A. Cornea. In: Gold DH, Lewis RA, eds. Clinical Eye Atlas, 2nd ed., Chicago:AMA Press 2010 [in press]. Parker J, Tandon A, Shtein RM, Cooney TM, Musch DC, Soong HK, Sugar A, Mian SI. Management of pain with diclofenac after LASIK with femtosecond laser. J Cataract Refract Surg 2010 (in press).

Sayoko E. Moroi, M.D., Ph.D. Michael J. Lipson, O.D., FAAO Grants See grants, page 56 Awards/Honors/Leadership • Invited speaker, Global Specialty Lens Symposium • Invited speaker, Association of Optometric Contact Lens Educators

university of michigan kellogg eye center

Grants See grants, page 57 Awards/Honors/Leadership • Best Doctors in America • Invited speaker, Glaucoma Specialty Day, American Academy of Ophthalmology Annual Meeting • Keynote Speaker, Ohio Ophthalmological Society Meeting

Faculty honors, recognition, and publications • Invited speaker, XXXIX Nordic Congress of Ophthalmology, Reykjavik • Member, Glaucoma Subcommittee, National Eye Health Education Program Planning Committee, NIH Publications John DA, Stein JD, Moroi SE. Intraocular foreign bodies. Eyenet, September 2009. Weizer JS, Goyal A, Ple-Plakon P, Trzcinka A, Strong BD, Bruno CA, Junn J, Tseng I, Niziol LM, Musch DC, Moroi SE. Bleb morphology characteristics and effect on positional intraocular pressure variation. Ophthalmic Surg Lasers Imaging 2010;41:532-537. Moroi SE. Eyelash preservation during chemotherapy and topical prostaglandin therapy. Arch Intern Med 2010;170(14):1269-1270.

David C. Musch, Ph.D., M.P.H. Grants See grants, page 57 Awards/Honors/Leadership • Lew R. Wasserman Merit Award recipient, Research to Prevent Blindness • Editorial Board, Ophthalmology • Editorial Board, Retina • Faculty Associate, Center for Global Health, University of Michigan • Scientific Advisory Board, Clinical and Translational Science Award, Michigan Institute for Clinical and Health Research • Chair, Special Emphasis Grant Review Panel, National Eye Institute, NIH • Reviewer, National Medical Research Council, Singapore • Methodologist, Cornea and External Disease Preferred Practice Pattern Panel, American Academy of Ophthalmology • Member, Advisory Group, Cochrane Collaboration Eyes and Vision Group US Project • Course Director, ARVO Foundation for Eye Research Clinical Trials Education series, San Francisco, CA • Consultant, Ophthalmic Devices Panel, U.S. Food and Drug Administration • Member, Policy and Data Monitoring Board, Longitudinal Study of Ocular Complications of AIDS, NEI/NIH • Chair, Data Monitoring Oversight Committee, Telemedicine Approaches to Evaluating Acute-phase ROP (eROP), NEI/NIH • Invited speaker, Vision Seminar Series, Washington University Publications Lee WB, Jacobs DS, Musch DC, Kaufman SC, Reinhart WJ, Shtein RM. Descemet’s stripping endothelial keratoplasty: safety and outcomes. A report by the American Academy of Ophthalmology. Ophthalmology 2009; 116:1818-1830.

Friberg TR, Brennen PM, Freeman WR, Musch DC, PTAMD Study Group. Prophylactic treatment of age-related macular degeneration report #2: 810-nanometer laser to eyes with drusen: bilaterally eligible patients. Ophthalmic Surg Lasers Imaging 2009; 40:530-538. Mian SI, Li AY, Dutta S, Musch DC, Shtein RM. Dry eyes and corneal sensation after LASIK with the IntraLase® femtosecond laser: Effect of hinge position, hinge angle, and flap thickness. J Cataract Refract Surg 2009;35:2092-2098. Stein JD, Newman-Casey PA, Niziol LM, Gillespie BW, Lichter PR, Musch DC. The association between the use of glaucoma medications and mortality. Arch Ophthalmol 2010;128:235-240. Jayasundera T, Rhoades W, Branham K, Niziol LM, Musch DC, Heckenlively JR. Peripapillary dark choroid ring as a helpful diagnostic sign in advanced Stargardt disease. Am J Ophthalmol 2010;149:656-660. Weizer JS, Goyal A, Ple-Plakon P, Trzcinka A, Strong BD, Bruno CA, Junn J, Tseng I, Niziol LM, Musch DC, Moroi SE. Bleb morphology characteristics and effect on positional intraocular pressure variation. Ophthalmic Surg Lasers Imaging 2010;41:532-537. Radcliffe NM, Musch DC, Niziol LM, Liebmann JM, Ritch R. The effect of trabeculectomy on intraocular pressure of the untreated fellow eye in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology 2010 [in press]. Stein JD, Kim DS, Niziol LM, Talwar N, Nan B, Musch DC, Richards JE. Differences in rates of glaucoma among Asian Americans compared with other races and among individuals of different Asian ethnicities. Ophthalmology 2010 [in press]. Chen PP, Musch DC, Niziol LM. The effect of early post-trabeculectomy intraocular pressure spike in the Collaborative Initial Glaucoma Treatment Study. J Glaucoma 2010 [in press]. Malta JB, Soong HK, Shtein RM, Musch DC, Rhoades W, Sugar A, Mian SI. Treatment of ocular graft-versus-host disease with topical cyclosporine 0.05%. Cornea 2010 [in press]. Kymes SM, Lambert DL, Lee PP, Musch DC, Siegfried CJ, Kotak SV, Stwalley DL, Fain J, Johnson CJ, Gordon MO. The development of a decision analytic model of changes in mean deviation in people with glaucoma: the COA model. Am J Ophthalmol 2010 [in press].

Choe CH, Guss C, Musch DC, Niziol LM, Shtein RM. Incidence of diffuse lamellar keratitis after LASIK with 15 KHz, 30 KHz and 60 KHz IntraLase femtosecond laser flap creation. J Cataract Refract Surg 2010 [in press]. Parker J, Tandon A, Shtein RM, Cooney TM, Musch DC, Soong HK, Sugar A, Mian SI. Management of pain with diclofenac after LASIK with femtosecond laser. J Cataract Refract Surg 2010 [in press].

Christine C. Nelson, M.D., FACS Awards/Honors/Leadership • Best Doctors in America • Visiting Professor, Institut Regional de Oftalmologia, Trujillo, Peru • Invited speaker, Minnesota Academy of Medicine • Invited speaker, American Society of Ophthalmic Plastic & Reconstructive Surgery, 40th Annual Scientific Symposium • Invited speaker, 2nd Annual Detroit Regional Ophthalmology Interchange Publications Koreen IV, Flint A, Nelson CC, Frueh BR, Elner VM. Non-diagnostic conjunctival map biopsies for sebaceous carcinoma. Arch Ophthalmol 2009;127:961-963. Demirci H, Frueh BR, Nelson CC. Marcus Gunn Jaw Winking Synkinesis: clinical features and management. Ophthalmology 2010;117:1447-1452.

Howard R. Petty, Ph.D. Grants See grants, page 57 Publications Yang D, Elner SG, Lin L-R, Reddy VN, Petty HR, Elner VM. Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci 2009;50:49985005. Petty HR, Elner VM, Kawaji T, Clark AJ, Thompson D, Yang D. A facile method for immunofluorescence microscopy of highly autofluorescent human retinal sections using nanoparticles with large Stokes shifts. J Neurosci Methods 2010;191:222-226. Sitrin RG, Sassanella TM, Landers J, Petty HR. Migrating human neutrophils exhibit dynamic spatiotemporal variation in membrane lipid composition. Amer J Respir Cell Mol Biol 2010;43:498-506. Clark AJ, Petty HR. A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils. Cell Immunol 2010;261:153-158.

Dedicated to Discovery

Faculty honors, recognition, and publications Zhu A, Romero R, Petty HR. Amplex ultrared enhances the sensitivity of fluorimetric pyruvate detection. Anal Biochem 2010:430;123125. Xu Y, Madsen-Bouterse SA, Romero R, Hassan S, Mittal P, Elfline M, Zhu A, Petty HR. Leukocyte pyruvate kinase expression is reduced in normal human pregnancy but not in pre-eclampsia. Am J Reprod Immunol 2010;64,137-151. Clark AJ, Romero R, Petty HR. Improved detection of NAD(P)H oscillations within human neutrophils: a population study. Cytometry 2010;77A:976-982. Zhu A, Romero R, Huang J-B, Clark A, Petty HR. Maltooligosaccharides from JEG-3 trophoblast-like cells exhibit immunoregulatory properties. Am J Reprod Immunol 2010 [in press]. Elfline M, Clark A, Petty HR, Romero R. Bi-directional calcium signaling between adjacent leukocytes and trophoblast-like cells. Am J Reprod Immunol 2010 [in press]. Sitrin RG, Sassamella TM, Petty HR. An obligate role for membrane-associated neutral spingomyelinase activity in orienting chemotactic migration of human neutrophils. Amer J Respir Cell Mol Biol 2010 [in press].

Donald G. Puro, M.D., Ph.D. Grants See grants, page 57 Awards/Honors/Leadership • Best Doctors in America • Editorial Board, Microcirculation Publications Matsushita K, Fukumoto M, Kobayashi T, Kobayashi M, Minami M, Katsumura K, Liao SD, Wu DM, Puro DG. Diabetes-induced inhibition of voltage-dependent calcium channels in the retinal microvasculature: role of spermine. Invest Ophthalmol Vis Sci 2010 [in press].

Julia E. Richards, Ph.D. Grants See grants, page 57 Awards/Honors/Leadership • Director, Glaucoma Research Center, University of Michigan Kellogg Eye Center • Member, Scientific Advisory Board, The Glaucoma Foundation • Grant Review Panel, The Glaucoma Foundation • Member, Glaucoma Research Society, International Congress of Ophthalmology • Ad hoc reviewer, AED Study Section, National Eye Institute, NIH • Fellow, Association for Research in Vision and Ophthalmology 52

Publications Stein JD, Kim DS, Niziol LM, Talwar N, Nan B, Musch DC, Richards JE. Differences in rates of glaucoma among Asian Americans compared with other races and among individuals of different Asian ethnicities. Ophthalmology 2010 [in press]. Richards JE, Hawley RS. The Human Genome: A User’s Guide, 3rd ed. San Diego:Elsevier 2010 [in press].

Stephen J. Saxe, M.D. Awards/Honors/Leadership • Best Doctors in America • Invited speaker, Twenty-First Annual Midwest Ocular Angiography Conference, Reykjavik, Iceland

Roni M. Shtein, M.D. Grants See grants, page 57 Awards/Honors/Leadership • Methodologist, Cornea/Anterior Segment Panel, Ophthalmic Technology Assessment Committee, American Academy of Ophthalmology • Member, Vision Research Training Program, University of Michigan Kellogg Eye Center • Member, Unified Curriculum Committee, University of Michigan • Member, Accreditation Board, Eye Bank Association of America Publications Lee WB, Jacobs DS, Musch DC, Kaufman SC, Reinhart WJ, Shtein RM. Descemet’s stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology. Ophthalmology 2009;116:1818-1830. Mian SI, Li AY, Dutta S, Musch DC, Shtein RM. Dry eyes and corneal sensation after LASIK with the IntraLase® femtosecond Laser: Effect of hinge position, hinge angle, and flap thickness. J Cataract Refract Surg 2009;35: 2092-2098. Shtein RM, Elner VM. Herpes simplex virus keratitis: histopathology and corneal allograft outcomes. Expert Rev Ophthalmol 2010;5:129-134. Choe CH, Guss C, Musch DC, Niziol LM, Shtein RM. Incidence of diffuse lamellar keratitis after LASIK with 15 KHz, 30 KHz and 60 KHz IntraLase femtosecond laser flap creation. J Cataract Refract Surg 2010 [in press]. Parker J, Tandon A, Shtein RM, Cooney TM, Musch DC, Soong KH, Sugar A, Mian SI. Management of pain with diclofenac after LASIK with femtosecond laser. J Cataract Refract Surg 2010 (in press).

university of michigan kellogg eye center

Malta JB, Soong HK, Shtein RM, Musch DC, Rhoades W, Sugar A, Mian SI. Treatment of ocular graft-versus-host disease with topical cyclosporine 0.05%. Cornea 2010 [in press]. Shtein RM, Newton DW, Elner VM. Actinomyces infectious crystalline keratopathy. Arch Ophthalmol 2010 [in press]. Shtein RM, Sugar A. Lens and Cataract. In: Gold DH, Lewis RA, eds. Clinical Eye Atlas, 2nd ed., Chicago:AMA Press 2010 [in press].

Terry J. Smith, M.D. Grants See grants, page 57 Awards/Honors/Leadership • Best Doctors in America • Invited speaker, International Symposium on Graves’ Orbitopathy, Royal Netherlands Academy of Arts and Sciences, Amsterdam • Invited speaker, Summer Research Seminar, University of Michigan – Biomedical Research Program Publications Douglas RS, Tsirbas A, Gordon M, Lee D, Khadavi N, Garneau HC, Goldberg RA, Cahill K, Dolman PJ, Elner V, Feldon S, Lucarelli M, Uddin J, Kazim M, Smith TJ, Khanna D. Development of criteria for evaluating clinical response in thyroid eye disease using a modified Delphi technique. Arch Ophthalmol 2009;127:1155-1160. Khanna D, Chong KL, Afifiyan HF, Hwang CJ, Lee DK, Garneau HC, Goldberg RA, Darwin CH, Smith TJ, Douglas RS. Rituximab treatment of patients with severe, corticosteroidresistant thyroid-associated ophthalmopathy. Ophthalmology 2010;117:179-186. Warstat K, Hoberg M, Rudert M, Tsui S, Pap T, Angres B, Essl M, Smith TJ, Cruikshank W, Klein G, Gay S, Aicher WK. Transforming growth factor ß1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis. Ann Rheum Dis 2010;69:270-275. Douglas RS, Affiyan NF, Hwang CJ, Chong K, Haider U, Richards P, Gianoukakis AG, Smith TJ. Increased generation of fibrocytes in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 2010;95:430-438. Naik VM, Naik MN, Goldberg RA, Smith TJ, Douglas RS. Immunopathogenesis of thyroid eye disease: emerging paradigms. Surv Ophthalmol 2010;55:215-226. Smith TJ. Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev 2010;62:199-236. Smith TJ. Pathogenesis of Graves’ orbitopathy: A 2010 update. J Endocrinol Invest 2010;33:414-421.

Faculty honors, recognition, and publications Smith TJ. Do bone marrow-derived fibrocytes account for fibroblast heterogeneity? A novel paradigm for the autoimmunity underlying thyroid-associated ophthalmopathy. Clin Exp Immunol 2010;162:24-31. Hegedus L, Smith TJ, Douglas RS, Nielsen CH. Targeted biological therapies for Graves’ disease and thyroid associated ophthalmopathy. Focus on B cell depletion with Rituximab. Clin Endocrinol 2010 [in press].

Michael W. Smith-Wheelock, M.D. Awards/Honors/Leadership • Best Doctors in America • Medical Director, Ambulatory Care Unit, University of Michigan Kellogg Eye Center • Director, Medical Student Clerkship Program, University of Michigan Department of Ophthalmology and Visual Sciences • Chair, OR committee, University of Michigan Kellogg Eye Center

H. Kaz Soong, M.D. Awards/Honors/Leadership • Best Doctors in America • Board of Trustees, Haiti Nursing Foundation, U-M Nursing School and Leogane Nursing School • Visiting Professor, University Hospital of Haiti • Visiting Professor, Zhoushan Hospital, Shanghai, China Publications Lass JH, Sugar A, Benetz BA, Soong HK. Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty. Arch Ophthalmol 2010;128:63-69. Romero IL, Malta JB, Cely CB, Mimica LM, Soong HK, Hida RY. Antibacterial properties of cyanoacrylate adhesive (letter to the editor). Indian J Ophthalmol 2010;58(4): 348. LeBoyer RM, Soong HK. Complications of contact lenses. Up-To-Date, Jan 2010. Parker J, Tandon A, Shtein RM, Cooney TM, Musch DC, Soong HK, Sugar A, Mian SI. Management of pain with diclofenac after LASIK with femtosecond laser. J Cataract Refract Surg 2010 (in press). Malta JB, Soong HK, Shtein RM, Musch DC, Rhoades W, Sugar A, Mian SI. Treatment of ocular graft-versus-host disease with topical cyclosporine 0.05%. Cornea 2010 [in press]. Outreach and Public Service Emergency relief visit, Haiti, Jan., 2010. Haiti Relief Task Force, American Academy of Ophthalmology

Joshua D. Stein, M.D. Grants See grants, page 58 Awards/Honors/Leadership • BCBSM Foundation McDevitt Excellence in Research Award • Anthony Adamis Prize for Outstanding Research in Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center • Token of Appreciation from Medical Students (TAMS) Award recipient, University of Michigan • Editorial Board, Evidence-Based Ophthalmology Publications Stein JD, McCoy AN, Asrani S, Herndon LW, Lee PP, McKinnon SJ, Allingham RR, Challa P. Surgical management of hypotony due to overfiltration in eyes receiving glaucoma drainage devices. J Glaucoma 2009;18:638641. John DA, Stein JD, Moroi SE. Intraocular foreign bodies. Eyenet, September 2009. Weizer JS, Stein JD. Reader’s Digest Guide To Eye Care. New York:Readers Digest, 2009. Stein JD, Newman-Casey PA, Niziol LM, Gillespie BW, Lichter PR, Musch DC. The association between the use of glaucoma medications and mortality. Arch Ophthalmol 2010;128:235-240. Koreen I, Gupta C, Asrani S, Bhagat N, Stein JD. Applications of optical coherence tomography in the diagnosis and management of glaucoma. In: Tasman W, Jaeger EA, eds., Duane’s Clinical Ophthalmology, Vol. III, chapter 54f, Philadelphia:Lippincott Williams & Wilkins, 2010 [in press] Stein JD, Kim DS, Niziol LM, Talwar N, Nan B, Musch DC, Richards JE. Differences in rates of glaucoma among Asian Americans compared with other races and among individuals of different Asian ethnicities. Ophthalmology 2010 [in press].

Alan Sugar, M.D. Grants See grants, page 58 Awards/Honors/Leadership • Best Doctors in America • Associate Editor, Cornea • Editorial Board, Ophthalmology • Board of Directors, Midwest Eye Banks • Board of Directors, World Eye Mission • Medical Advisory Board, Eye Bank Association of America • Chair, Research Committee, Eye Bank Association of America

• Chair, Ophthalmic Technology Assessment Committee, American Academy of Ophthalmology • Vice-Chair, IRBMED, University of Michigan Medical School Publications Huang D, Schallhorn SC, Sugar A, Farjo AA, Majmudar PA, Trattler WB, Tanzer DS. Phakic intraocular lens implantation for the correction of myopia. A report by the American Academy of Ophthalmology. Ophthalmology 2009;116:2244-2258. Sugar A. Herpes simplex keratitis. Up-ToDate, Release 17.3, September 2009. Malta J, Ahmad F, Mian S, Sugar A. Corneal inflammatory disorders. In: Trattler W, Majmudar P, Luchs J, Swartz T, eds. Cornea Handbook. Thorofare, NJ:Slack Inc, 2010, pp. 37-60. Mian S, Sugar A. Corneal complications after intraocular surgery. In: Krachmer J, Mannis M, Holland E, eds. Cornea, 3rd ed, London:Elsevier Mosby, 2010. Malta JB, Soong HK, Shtein R, Musch DC, Rhoades W, Sugar A, Mian SI. Treatment of ocular graft-versus-host disease with topical cyclosporine 0.05%. Cornea 2010 [in press]. Mian SI, Cooney T, Sugar A. Cornea. In: Gold DH, Lewis RA, eds. Clinical Eye Atlas, 2nd ed., Chicago:AMA Press 2010 [in press]. Shtein RM, Sugar A. Lens and Cataract. In: Gold DH, Lewis RA, eds. Clinical Eye Atlas, 2nd ed., Chicago:AMA Press 2010 [in press]. Parker J, Tandon A, Shtein RM, Cooney TM, Musch DC, Soong HK, Sugar A, Mian SI. Management of pain with diclofenac after LASIK with femtosecond laser. J Cataract Refract Surg 2010 (in press).

Debra A. Thompson, Ph.D. Grants See grants, page 58 Awards/Honors/Leadership • Fellow, Association for Research in Vision and Ophthalmology Publications Petty HR, Elner VM, Kawaji T, Clark AJ, Thompson D, Yang D. A facile method for immunofluorescence microscopy of highly autofluorescent human retinal sections using nanoparticles with large Stokes shifts. J Neurosci Methods 2010;191:222-226. Marchette LD, Thompson DA, Kravtsova M, Ngansop TN, Mandal MNA, Kasus-Jacobi A. Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. Free Radic Biol Med 2010;48:16-25.

Dedicated to Discovery

Faculty honors, recognition, and publications Friedman JS, Chang B, Krauth DS, Lopez I, Waseem NH, Hurd RE, Feathers KL, Branham KE, Shaw M, Thomas GE, Brooks MJ, Liu C, Bakeri HA, Campos MM, Maubaret C, Webster AR, Rodriguez IR, Thompson DA, Bhattacharya SS, Koenekoop RK, Heckenlively JR, Swaroop A. Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice. Proc Natl Acad Sci U S A 2010;107:15523-15528. Yao J, Feathers KL, Khanna H, Thompson DA, Tsilfidis C, Hauswirth WW, Heckenlively JR, Swaroop A, Zacks DN. XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina. Invest Ophthalmol Vis Sci 2010 [in press]. Gearhart PM, Gearhart C, Thompson DA, Petersen-Jones SM. Intravitreal administration of 9-cis-retinal improves visual performance in RPE65 mutant dogs. Arch Ophthalmol 2010 [in press].

Susan S. Thoms, M.D. Awards/Honors/Leadership • Best Doctors in America

Jonathan D. Trobe, M.D. Grants See grants, page 58 Awards/Honors/Leadership • Best Doctors in America • Editor-in-Chief, Journal of Neuro Ophthalmology • Invited speaker, University of South Florida • Invited speaker, Pittsburgh Ophthalmological Society • Invited speaker, American Academy of Neurology • Invited speaker, International Neuro Ophthalmologic Society, Lyon, France Publications Margolin EA, Dev LS, Trobe JD. Prevalence of retinal hemorrhages in perpetrator-confessed cases of abusive head trauma. Arch Ophthalmol 2010;128:795. Bujak M, Margolin E, Thompson A, Trobe JD. Spontaneous resolution of two dural carotidcavernous fistulas presenting with optic neuropathy and marked congestive ophthalmopathy. J Neuroophthalmol 2010;30:222-227.

Garton HJ, Gebarski SS, Ahmad O, Trobe JD. Clival epidural hematoma in traumatic sixth cranial nerve palsies combined with cervical injuries. J Neuroophthalmol 2010;30:18-25. Trobe JD. The evaluation of Horner syndrome. J Neuroophthalmol 2010;30:1-2. Trobe JD. The way we’ve been: The Journal of Neuro-Ophthalmology, 2001-2010. J Neuroophthalmol 2010;30:3-4.

Jennifer S. Weizer, M.D. Publications Weizer JS, Stein JD. Reader’s Digest Guide To Eye Care. New York:Readers Digest, 2009. Weizer JS, Goyal A, Ple-Plakon P, Trzcinka A, Strong BD, Bruno CA, Junn J, Tseng I, Niziol LM, Musch DC, Moroi SE. Bleb morphology characteristics and effect on positional intraocular pressure variation. Ophthalmic Surg Lasers Imaging 2010;41:532-537. Weizer JS. Scheie syndrome and narrow angles. Glaucoma Today 2010;8:55-57.

Donna M. Wicker, O.D., FAAO Awards/Honors/Leadership • Invited speaker, National Foundation for the Blind, Midwest Chapter Outreach and Public Service • Guest speaker on low vision, Ann Arbor District Library

Kwoon Y. Wong, Ph.D. Grants See grants, page 58 Awards/Honors/Leadership Publications Dumitrescu ON, Pucci FG, Wong KY, Berson DM. Ectopic retinal ON bipolar cell synapses in the OFF inner plexiform layer: contacts with dopaminergic amacrine cells and melanopsin ganglion cells. J Comp Neurol 2009;517(2):226-244. Weng S, Wong KY, Berson DM. Circadian modulation of melanopsin-driven light response in rat ganglion-cell photoreceptors. J Biol Rhythms 2009;24(5):391-402.

Parmar H, Trobe JD. A “first cut” at interpreting brain MRI signal intensities: what’s white, what’s black, and what’s gray. J Neuroophthalmol 2010;30:91-93.

university of michigan kellogg eye center

Dongli Yang, M.D., Ph.D. Publications Yang D, Elner SG, Lin L-R, Reddy VN, Petty HR, Elner VM. Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci 2009;50:4998-5005. Petty HR, Elner VM, Kawaji T, Clark AJ, Thompson D, Yang D. A facile method for immunofluorescence microscopy of highly autofluorescent human retinal sections using nanoparticles with large Stokes shifts. J Neurosci Methods 2010;191:222-226.

David N. Zacks, M.D., Ph.D. Grants See grants, page 58 Awards/Honors/Leadership • Best Doctors in America • Terry J. Bergstrom Faculty Teaching Award, University of Michigan Kellogg Eye Center • Editorial Board, Current Eye Research • Writing Committee, Basic and Clinical Science Course, Retina Vol 12, American Academy of Ophthalmology Outreach and Public Service • Honorary Co-Chair, Foundation Fighting Blindness Eastern Michigan Vision Walk Publications Besirli CG, Chinskey ND, Zheng QD, Zacks DN. Inhibition of retinal detachment-induced apoptosis in photoreceptors by a small peptide inhibitor of the Fas receptor. Invest Ophthalmol Vis Sci 2010;51:2177-2184. Yao J, Feathers KL, Khanna H, Thompson DA, Tsilfidis C, Hauswirth WW, Heckenlively JR, Swaroop A, Zacks DN. XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina. Invest Ophthalmol Vis Sci 2010 [in press].

grants

Faculty Name

Source

Project Title

T. Bergstrom, M.D. NIH/Clinical Trial U10-EY010439-15 Ocular Hypertension Treatment Study (OHTS) Coordinating Center: Washington University G. Comer, M.D. Ocuscience/Clinical Trial Study of Retinal Flavoprotein Autofluorescence in Macular Degeneration LMRI/Clinical Trial A Natural History Study of Macular Telangiectasia — The MacTel Study W. Cornblath, M.D. ICON Clinical Research/Pfizer Case-Crossover Study of PDE5 Inhibitor Exposure as a Potential “Trigger Factor” for Acute NAION J. Demb, Ph.D. NIH R01-EY014454-06 Neural Circuits & Synapses for Early Visual Processing R01-EY014454-06-S1 RPB Career Development Award R. Douglas, M.D., Ph.D. NIH

K23-EY016339-06 Immune Activation of Fibroblasts

S. Elner, M.D. NIH/Clinical Trial U10-EY014660 Multicenter Uveitis Steroid Treatment (MUST) Trial Coordinating Center: Johns Hopkins University V. Elner, M.D., Ph.D. NIH R01-EY009441-13 RPE-MΦ Binding: Ca++ & O2- Dependent AMD Responses RPB Senior Scientific Investigator Award Michigan Universities Prototype Development ETCF Grant Commercialization Initiative P. Gage, Ph.D. NIH R01-EY014126-07 Pitx 2: Molecular Mechanisms in Eye Development and Disease J. Heckenlively, M.D. NIH R01-EY007758-20 Mouse Models of Human Hereditary Eye Diseases NIH R01-EY016862-05 Genetic Variations in Age-related Macular Degenerations FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Assessment of Therapies FFB Resource Facility for X-linked Retinitis Pigmentosa and Age-related Macular Degeneration Neurotech USA Phase II/III Study of Encapsulated Human Cell Implants Releasing CNTF for Participants with Retinitis Pigmentosa Sramek Foundation Interactive and Integrated Genetic Databases for the Study of Age-related Macular Degeneration P. Hitchcock, Ph.D. NIH R01-EY007060-20 Neuronal Development, Injury and Regeneration in Retina NIH R01-EY011115-12 Molecular Mechanisms of Retina-specific Gene Expression NIH T32-EY013934-08 Vision Research Training Program RPB Senior Scientific Investigator Award

Dedicated to Discovery

grants

Faculty Name

Source

Project Title

B. Hughes, Ph.D. NIH P30-EY007003-24 Core Center for Vision Research (five core modules) NIH R01-EY008850-19 Ion Conductances in the Retinal Pigment Epithelium RPB Lew R. Wasserman Award M. Johnson, M.D. Chiltern International/ThromboGenics Inc. A Randomized, Placebo-controlled, Double-masked, Multicenter Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion GlaxoSmithKline/Clinical Trial Study to Investigate Pharmacodynamics, Safety, and Systemic Pharmacokinetics of Pazopanib Eye Drops Regeneron Pharmaceutical/Clinical Trial Phase III Study of Efficacy, Safety, and Tolerability of Repeated Doses of Intravitreal VEGF Trap in Subjects with Neovascular AMD A. Kahana, M.D., Ph.D. NIH K08-EY018689-03 Zebrafish Model for Studying Orbital Development K08-EY018689-02-S1 and Disease FFB Development and Regeneration of Extraocular Muscles in Zebrafish - Student Fellowship RPB Career Development Award Sigma Xi Society Development and Regeneration of Extraocular Muscles in Zebrafish - Student Stipend Award H. Khanna, Ph.D. NIH R01-EY007961-21 X-Linked Retinitis Pigmentosa NIH R01-DC009606-02 Olfactory Signaling, Cilia, and Sensory Disorders Subcontract with Jeffrey Martens, Ph.D., Department of Pharmacology, University of Michigan FFB Center for the Study of Retinal Degenerative Diseases Midwest Eye-Banks Cilia Dependent Signal Transduction in Photoreceptor Degeneration U-M Center for Rare Disease Ciliary Signaling Cascades in Retinal and Syndromic Ciliopathies P. Lichter, M.D. RPB Unrestricted Grant VisionCare Ophthalmic Technologies/ VisionCare Ophthalmic Technologies Implantable Clinical Trial Miniature Telescope for Central Vision Impairment Associated with Age-related Macular Degeneration and Other Maculopathies M. Lipson, O.D.

EyeVis L.L.C.

Stabilizing Myopia by Accelerated Reshaping Technique

S. Mian, M.D. MICHR, Midwest Eye-Banks Femtosecond Laser-assisted Keratoplasty Midwest Eye-Banks Role of IGF-1 Signaling in Orbital Development in Zebrafish-Student Stipend Award

university of michigan kellogg eye center

grants

Faculty Name

Source

Project Title

S. Moroi, M.D., Ph.D. Merck and Company, Inc. Merck IISP #31911 Study: Effect of Myocilin Genetic Variants on Intraocular Pressure and Pressure Variation in Sitting and Supine Positions Midwest Eye-Banks Identifying Genomic Determinants of Thin Central Cornea as Risk Factor for Glaucoma D. Musch, Ph.D., M.P.H. NIH R21-EY118690-02 Clinical and Quality of Life Insights on Glaucoma from Analyses of CIGTS Data RPB Lew R. Wasserman Award Washington University/Pfizer Value Estimation Project in Glaucoma (Phase II) Subcontract with Washington University Michigan Center for Advancing A Survey of Vision Care Providers for Older Drivers Safe Transportation throughout the Lifespan H. Petty, Ph.D. NIH N01-HD-2-3342 Services in Support of the Perinatology Research Branch Subcontract with Wayne State University NIH R01-CA074120-10 Signaling Dynamics of Leukocyte-Tumor Cell Interactions NIH R01-AI060983-04 Lipid Raft Microdomains in Neutrophil Function Subcontract, Robert Sitrin, M.D., U-M Medical School Midwest Eye-Banks Retinal Metabolic Analysis of Glaucoma D. Puro, M.D., Ph.D. NIH R01-EY012507-11 Physiology of Retinal Pericytes RPB Senior Scientific Investigator Award Knights Templar Eye Foundation Physiology of Early Postnatal Retinal Microvessels and Implications for Retinopathy of Prematurity Award for David Wu, M.D., Ph.D. J. Richards, Ph.D. NIH R56-EY011671-10 Molecular Genetics of Glaucoma and Related Disorders NIH R01-EY019126-02-S1 Admixture Mapping of Glaucoma Genes in African Americans; subcontract with Duke University RPB Senior Scientific Investigator Award R. Shtein, M.D. NIH K23-EY017885-03 Neovascularization Patterns in Corneal Graft Rejection MICHR Pathogenesis of Idiopathic Dry Eye OVPR Faculty Grants and Awards Evaluation of Growth Factors in Tears of Patients with HSV Keratitis U-M Medical School Clinical Sciences Scholars Program Award T. Smith, M.D. NIH R01-EY008976-17 Regulation of Retro-ocular Connective Tissue NIH R01-EY011708-14 Functional Diversity of Orbital Fibroblasts NIH R01-DK063121-06 Immunoglobulin Activation of Fibroblasts RPB Physician Scientist Award

Dedicated to Discovery

grants

Faculty Name

Source

Project Title

J. Stein, M.D. NIH K23-EY019511-02 Association between Cataract Surgery and Progression of Diabetic Retinopathy American Glaucoma Society Mentoring for Advancement of Physician-Scientist Enabling Award Program American Glaucoma Society Racial Disparities in the Care of Elderly Americans with Glaucoma Blue Cross Blue Shield of Michigan Longitudinal Rates of Postoperative Adverse Outcomes after Glaucoma Surgery among Medicare Beneficiaries 1994-2005 Midwest Eye-Banks Monitoring of Patients for Ocular Side Effects of Corticosteroids A. Sugar, M.D. NIH/Clinical Trial U10-EY12358 Cornea Donor Study, Coordinating Center: Jaeb Lux Biosciences, Inc. A Randomized Dose-Ranging Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure following Penetrating Keratoplasty D. Thompson, Ph.D. FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Small Molecule Interventions RPB Visual Cycle Defects in Inherited Retinal Degeneration — Senior Scientific Investigator Award J. Trobe, M.D. University of Utah American Geriatrics Society

Proteomics and Genomics of Giant Cell Arteritis

K. Wong, Ph.D. NIH R00-EY018863-03 Cross-Talk between Ganglion-Cell Photoreceptors and Other Neurons in the Retina D. Zacks, M.D., Ph.D. FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Transplantation of Photoreceptor Precursors Lincy Foundation Preventing Photoreceptor Cell Death in Age-related Macular Degeneration Midwest Eye-Banks Activation of Autophagy During Retinal Detachment Midwest Eye-Banks Student Stipend Award RPB Sybil B. Harrington Special Scholar Award for Macular Degeneration

Source Abbreviations FFB – Foundation Fighting Blindness LMRI – Lowy Medical Research Institute MICHR – Michigan Institute for Clinical and Health Research

university of michigan kellogg eye center

NIH – National Institutes of Health OVPR – Office of the Vice President for Research, University of Michigan RPB – Research to Prevent Blindness

Faculty of the Department of Ophthalmology and Visual Sciences Paul R. Lichter, M.D., FACS Chair Glaucoma, Cataract and Anterior Segment Disease Steven F. Abcouwer, Ph.D. Vision Research James L. Adams, M.D. Eye Plastic, Orbital and Facial Cosmetic Surgery David A. Antonetti, Ph.D. Vision Research Steven M. Archer, M.D. Pediatric Ophthalmology and Adult Strabismus Terry J. Bergstrom, M.D. Comprehensive Ophthalmology Donald S. Beser, M.D., FACS Comprehensive Ophthalmology

Raymond S. Douglas, M.D., Ph.D. Eye Plastic, Orbital and Facial Cosmetic Surgery Elizabeth Du, M.D. Comprehensive Ophthalmology Susan G. Elner, M.D. Retina Victor M. Elner, M.D., Ph.D. Eye Plastic, Orbital and Facial Cosmetic Surgery Jerome I. Finkelstein, M.D., FACS Comprehensive Ophthalmology Patrice E. Fort, Ph.D. Vision Research Carlton J. Foster, O.D. Pediatric Ophthalmology and Adult Strabismus

Jill E. Bixler, M.D. Comprehensive Ophthalmology

Bruce A. Furr, C.O., M.S.P.H. Pediatric Ophthalmology and Adult Strabismus

Grant M. Comer, M.D. Retina

Philip J. Gage, Ph.D. Vision Research

Theresa M. Cooney, M.D. Cornea and External Disease, Cataract and Refractive Surgery

Christopher Gappy, M.D. Pediatric Ophthalmology and Adult Strabismus

Wayne T. Cornblath, M.D. Neuro-Ophthalmology

Thomas W. Gardner, M.D., M.S. Retina

Sherry H. Day, O.D. Contact Lens, Low Vision and Visual Rehabilitation

Hilary M. Grabe, M.D. Comprehensive Ophthalmology

Diane M. Jacobi, O.D. Contact Lens, Low Vision and Visual Rehabilitation Denise A. John, M.D., FRCSC Glaucoma, Cataract and Anterior Segment Disease Mark W. Johnson, M.D. Retina Alon Kahana, M.D., Ph.D. Eye Plastic, Orbital and Facial Cosmetic Surgery Harjeet Kaur, M.D., FRCS(I) Comprehensive Ophthalmology Naheed W. Khan, Ph.D. Vision Research

Terry J. Smith, M.D. Eye Plastic, Orbital and Facial Cosmetic Surgery Endocrinology Michael W. Smith-Wheelock, M.D. Comprehensive Ophthalmology H. Kaz Soong, M.D. Cornea and External Disease, Cataract and Refractive Surgery Joshua D. Stein, M.D., M.S. Glaucoma, Cataract and Anterior Segment Disease

Helios T. Leung, Ph.D., O.D., FAAO Contact Lens, Low Vision and Visual Rehabilitation

Alan Sugar, M.D. Cornea and External Disease, Cataract and Refractive Surgery

Cheng-mao Lin, Ph.D. Vision Research

Bradley W. Taylor, O.D., M.P.H. Contact Lens, Low Vision and Visual Rehabilitation

Michael J. Lipson, O.D., FAAO Contact Lens, Low Vision and Visual Rehabilitation Shahzad I. Mian, M.D. Cornea and External Disease, Cataract and Refractive Surgery Sayoko E. Moroi, M.D., Ph.D. Glaucoma, Cataract and Anterior Segment Disease David C. Musch, Ph.D., M.P.H. Vision Research Arivalagan Muthusamy, Ph.D. Vision Research Sudha Nallasamy, M.D. Pediatric Ophthalmology and Adult Strabismus Christine C. Nelson, M.D., FACS Eye Plastic, Orbital and Facial Cosmetic Surgery

Paul J. Grenier, O.D. Comprehensive Ophthalmology

Hemant Pawar, Ph.D. Vision Research

John R. Heckenlively, M.D. Retina

Howard R. Petty, Ph.D. Vision Research

Jonathan B. Demb, Ph.D. Vision Research

Peter F. Hitchcock, Ph.D. Vision Research

Donald G. Puro, M.D., Ph.D. Comprehensive Ophthalmology

Hakan Demirci, M.D. Orbital and Ocular Oncology

Bret A. Hughes, Ph.D. Vision Research

Julia E. Richards, Ph.D. Vision Research

Courtney A. Dewey, O.D. Pediatric Ophthalmology and Adult Strabismus

Ida L. Iacobucci, C.O. Pediatric Ophthalmology and Adult Strabismus

Gary S. Sandall, M.D., FACS Pediatric Ophthalmology and Adult Strabismus

Karen S. DeLoss, O.D. Contact Lens, Low Vision and Visual Rehabilitation

Roni M. Shtein, M.D. Cornea and External Disease, Cataract and Refractive Surgery

James G. Knaggs, M.D. Comprehensive Ophthalmology

Daniel G. Green, Ph.D. Vision Research

Monte A. Del Monte, M.D. Pediatric Ophthalmology and Adult Strabismus

Stephen J. Saxe, M.D., FACS Retina

Debra A. Thompson, Ph.D. Vision Research Susan S. Thoms, M.D. Comprehensive Ophthalmology Jonathan D. Trobe, M.D. Neuro-Ophthalmology Joshua P. Vrabec, M.D. Comprehensive Ophthalmology Jennifer S. Weizer, M.D. Glaucoma, Cataract and Anterior Segment Disease Adrienne L. West, M.D. Comprehensive Ophthalmology Donna M. Wicker, O.D., FAAO Contact Lens, Low Vision and Visual Rehabilitation Kwoon Y. Wong, Ph.D. Vision Research Maria A. Woodward, M.D. Cornea and External Disease, Cataract and Refractive Surgery Rebecca A. Wu, M.D. Comprehensive Ophthalmology David N. Zacks, M.D., Ph.D. Retina