2008 Annual Report - U-M Kellogg Eye Center by U-M Kellogg Eye Center

The Michigan Difference in Vision

UNIVERSIT Y OF MICHIGAN KELLOGG EYE CENTER 2008 ANNUAL REPORT

Table of Contents RESEARCH

New Use for Femtosecond Laser: Corneal Transplants. . . . . . . . . . . . . . . . . . . . . . 5

50 Years of Cornea Research at Kellogg. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Early Warning for Diabetes Appears in Snapshot of Eye.. . . . . . . . . . . . . . . . . . . 7

Study Reveals Gaps in Glaucoma Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Consortium Puts Retinitis Pigmentosa under the Microscope.. . . . . . . . . . . . . . . . . 9

EDUCATION

Iraq Veteran Hones Skills as Plastics Fellow.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

RetinaDx Goes Live. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2

Blueprint Drawn for 21st Century Resident Education Center.. . . . . . . . . . . . . . 1 3

Alums Care for Children Worldwide.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4

PATIENT CARE

Surgery Straightens Toddler’s Eyes.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 7

On the Road to Independent Living.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 8

African Teen Has Long Overdue Surgery.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 9

OUTREACH

Big Ten Doctors Go to Vietnam.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 0

GIVING

Ravitz Professorship Honors Ophthalmic Pathology.. . . . . . . . . . . . . . . . . . . . . . . 2 3

Carls Foundation Ushers in New Era of Pediatric Eye Care.. . . . . . . . . . . . . . . . 2 4

Eye Center Expansion Makes Rapid Progress. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 5

Kellogg Eye Center Expansion Honor Roll.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 6

Towsley Foundation Supports Expanded Ophthalmic Imaging Center.. . . . . . . 2 8

Fralick Society Recognizes Annual Donors.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9

Chair Receives Top Ophthalmology Award. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9

Annual Giving Honor Roll.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 0

DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES FACULTY Faculty Honors, Recognition and Publications.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4 Grants.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 4 Faculty Photos.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 8

2008 Annual Report • University of Michigan • W.K. Kellogg Eye Center This report covers the period July 1, 2007 through June 30, 2008

Dear Friends, The year has been marked by rapid progress on the Kellogg Eye Center Expansion, many new faculty initiatives and research advances, and, as always, exceptional generosity on the part of those who support the Eye Center. In this report, we have the opportunity to highlight the Cornea Service and its contributions to the Department over many years. Among the foremost contributors is Alan Sugar, M.D., nationally known for his leadership in that subspecialty. He is an expert on a complement of corneal disorders and surgeries, including corneal transplantation. He has served for many years as a medical director of the Michigan Eye-Banks, and is principal investigator for the Department’s arm of the Cornea Donor Study, a multi-center study sponsored by the National Eye Institute. Along with others of us, Dr. Sugar was in on early stages of discovery when the Department realized that an industrial laser, the femtosecond laser, could be used for eye surgery. That research resulted in the commercialization of a new laser for refractive surgery. Now Dr. Sugar and colleagues are investigating that laser’s use for corneal transplantation. Dr. Shahzad Mian leads a pilot study that investigates the femtosecond laser in cutting corneal tissue for the surgery, and he reports early positive outcomes. The Department continues its strong, long-standing reputation for research on retina function and disease. Such research has profound implications for understanding diseases that affect the vision of so many older individuals. As part of a new program initiated by the Foundation Fighting Blindness, several Kellogg scientists and clinicians are collaborating with colleagues from other institutions to create new treatments for retinitis pigmentosa, a disease that results in progressive loss of vision. The collaborative nature of the study is an example of research models now in favor among federal funding agencies. Pediatric ophthalmology at Kellogg has also grown at a record pace over the past several years. Far ahead of its peers, the Department announced in 1985 the nation’s first endowed pediatric ophthalmology chair, held then and now by Dr. Monte Del Monte. Since then we’ve added faculty and many more patients and today our children’s clinics are filled nearly to capacity. When the Eye Center Expansion opens in 2010 we will have a new spacious clinic, thanks to the Carls Foundation. Read about that organization’s generous support in this report. The recurring theme of growth, of course, is what has created the need for a new facility. And so this year, we celebrate the progress made toward the completion of the Eye Center expansion. In late fall we gathered to celebrate the completion of the steel structure and the traditional Topping Out ceremony. Before long the structure was completely enclosed. Now, as the clinics take shape inside and brick and glass appear outside, the new building is beginning to resemble the models and renderings we have viewed for the past couple of years. Each phase of construction brings us nearer to the day when we can realize our goal of having one of the finest, most advanced Eye Centers in the nation. So many individuals and organizations have supported our goals. Our new Fralick Society was formed to recognize annual partners in giving. And organizations like the Towsley Foundation are helping us build and name key components of the building. Take a minute, also, to run through the honor rolls in this report. We recognize and thank our supporters — friends, alumni, faculty and staff — who are committed to the growth of the Eye Center and believe in the power of its research programs to find new treatments for people with blinding eye disease.

Paul R. Lichter, M.D. F. Bruce Fralick Professor and Chair University of Michigan Department of Ophthalmology and Visual Sciences Director, W.K. Kellogg Eye Center

Building on Success In 1985 the W.K. Kellogg Eye Center opened. This ultra-modern eight-story building allowed us to expand our research and education efforts and our ability to care for patients needing advanced eye care. The new building also allowed us to bring our vision research scientists to a facility where they could easily exchange ideas with clinicians, nurturing the concepts of collaborative and translational research. That same year, 1985, the Eye Center employed 90 faculty and staff. If you follow the expanding circles on the charts below, you’ll see that we grew — in patient visits and in staff and faculty to serve them — beyond our greatest expectations.

In the late 1990s, Chair Paul R. Lichter, M.D., realized that we would outgrow this still seemingly brand new eye care facility. He commissioned a study and by 2005, the Regents of the University of Michigan had approved plans for expansion. When the U-M Kellogg Eye Center expansion opens in 2010, we expect that year’s tally of patient visits will approach 140,000. At the same time, the numbers of faculty and staff will increase to accommodate our patients and the urgent need to accelerate research efforts toward a cure for eye disease.

2010 Projected Patient Visits: 139,303

2005 Patient Visits: 119,915

1995 Patient Visits: 57,081

1985 Patient Visits: 36,852

2010 Expansion 230,000 sq. ft.

Growth in Patient Visits

1985 W.K. Kellogg Eye Center Research Tower and Clinic Building 147,442 sq. ft.

2010: 512 projected

2005: 410

1995: 198

In the spring of 2010, all clinics and surgical suites will move into the new U-M Kellogg Eye Center expansion. Research laboratories will be located in the Kellogg Research Tower (left) and in the upper floors of the new facility.

1985: 90

5% Eye Plastic Neuro

Faculty and Staff Growth since the W.K. Kellogg Center Opened Gifts Toward the New Building 2010: 512 projected

2005: 410

$5.7 million to goal

$20 Million Goal 1995: 198

1985: 90 $14.3 million raised

Gifts Toward theGifts NewToward Building Research and Endowment

$4.5 million to goal

$20 Million Goal

1% Glau Growth in research spurred the expansion of the Kellogg Eye Center. 6% Retina While our new building will enable us to accelerate efforts toward more effective treatments and cures for eye disease, it will also provide space for the growing number of individuals 8% Contact Lens Department Growt seeking eye care. Patients, faculty, in clinics by 2010 staff, alumni, and the community have generously supported the building campaign. Reaching our fundraising 10% Photography goals will ensure we can make the most of this unique moment in our history.

Gifts Toward the New Building Growth in Patient Visits

$5.7 million to goal

$20 Million Goal

$14.3 million raised

$20 Million Goal

$14.3 million raised

$15.5 million raised

university of michigan kellogg eye center

Gifts Toward Research and Endowment

Accelerating Research Through collaboration and individual effort, our scientists are achieving new insights into eye disease and treatment strategies. Their goal is to bring the best new therapies â&#x20AC;&#x201D; and hope â&#x20AC;&#x201D; to our patients and their families.

Shahzad I. Mian, M.D.

“We hope that with the use of the femtosecond laser, patients will have better vision, faster recovery of vision, and stronger wound construction ...” — Shahzad I. Mian, M.D.

Femtosecond laser could change corneal transplant surgery Early results show laser — developed at U-M for eye surgeries — improving corneal transplant outcomes Nearly 15 years ago, researchers at Kellogg were first to discover that the ultrafast or femtosecond laser, then used for industrial purposes, had great potential for eye surgeries that traditionally required a surgical blade. Faculty from Kellogg and the College of Engineering explored the laser’s surgical applications, and today it is used worldwide for LASIK surgery. Now, faculty hope for the same success in applying this exceptionally fast and precise laser to corneal transplant surgery. Physician–scientists at Kellogg are conducting a two-year pilot program — called the FLAK (Femtosecond Laser-Assisted Keratoplasty) study — which uses the femtosecond laser to perform full thickness corneal transplants. “We hope that with the use of the femtosecond laser, patients will have better vision, faster recovery of vision, and stronger wound construction that will provide more resistance to injury in the future,” says Shahzad I. Mian, M.D., assistant professor and Principal Investigator of the FLAK study. While lasers have been effective in eye surgeries for decades, they were not used for corneal transplants until the femtosecond laser was shown to be a superior cutting tool to the trephine, the cookie cutter-like knife currently used for transplants. “The advantage of this laser is that it allows the surgeon to focus the laser energy at a particular depth and then rapidly cut the tissue at that depth without causing any injury to the surrounding tissue,” says Dr. Mian. “It also allows the surgeon to pattern these cuts into shapes — such as a mushroom, a top hat or a zig zag — that allow for customized overlap between the donor’s corneal tissue and the patient’s corneal tissue.”

Because of the speed and precision of the femtosecond laser, the study results to date for corneal transplant surgery have been very encouraging, according to Dr. Mian. If these results hold true, a larger, multicenter clinical trial comparing this procedure to the traditional method could follow. The cornea is the clear, dome-shaped tissue covering the front of the eye. It is about the size of a dime and the thickness of a credit card. If the cornea becomes distorted in shape, or scarred or hazy from disease or injury, the light rays passing through it are distorted and vision is reduced. In some cases, corneal transplant surgery is necessary to replace the damaged cornea with a healthy donor cornea to restore good vision. Ophthalmologists perform more than 35,000 of these sight-saving procedures each year in the United States and, of all transplant surgeries done today, corneal transplants are the most common and most successful. Donor corneas are provided by eye banks and come from deceased individuals who arranged for donation prior to death or whose families gave consent.

Corneal transplant patient, Gary Abud, with clinic coordinator, Satavisha Dutta.

Accelerating Research

“This study indicates that corneas from older individuals are just as successful for corneal transplantation as those from younger donors.” — Alan Sugar, M.D.

Kellogg’s historical role in corneal transplantation Expanding the donor pool, improving success of transplants For years, U-M Kellogg Eye Center faculty have played a significant role in corneal transplantation. Kellogg ophthalmologists helped to establish the Michigan EyeBank in 1957, which resided in the Kellogg Eye Center until 2006. Faculty members have long collaborated with the Eye-Bank on research. In one recent example, Alan Sugar, M.D., cornea surgeon and professor of ophthalmology, led the Kellogg arm of Dr. Sugar led a team that studied age of cornea donors. a national study on cornea donor tissue. The study, sponsored by the National Eye Institute with tissue provided by the Midwest Eye-Banks, found strong support for raising the age limit for donors. A key finding of the study: the pool of corneal transplant donors — often limited to those 65 years of age and younger — should be expanded to include donors up to 75 years of age. According to the Cornea Donor Study, the success rate was the same whether the transplants were performed with corneas from donors ages 12 to 65 years or from donors ages 66 to 75. “This study indicates that corneas from older individuals are just as successful for corneal transplantation as those from younger donors,” said Dr. Sugar. He observes that in addition to expanding the pool of cornea donors, the study will help surgeons learn more about the procedure itself. “The study team is analyzing additional data that will help us understand more fully the factors involved in a successful cornea transplant,” he said. The Cornea Donor Study will continue for another five years, allowing more time to follow 6

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Dr. Shtein searches for ways to predict whether a cornea will be rejected after a transplant.

patients and interpret data. At the same time, cornea specialist Roni M. Shtein, M.D., is looking at another important aspect of corneal transplantation. One of the biggest concerns for patient and physician is that the new tissue will be rejected. In her study, Dr. Shtein will identify the characteristics of a patient’s cornea that could predict rejection of the new tissue. Specifically she will examine patterns of corneal neovascularization — the growth of blood vessels in the cornea — which is normally clear. In the first phase of the study she will determine the best way to measure these patterns. In the next and larger portion of the study, Dr. Shtein will develop ways to analyze characteristics of corneal neovascularization that can predict rejection or failure of the transplant. “This study is very specific in that it will allow us to identify high risk blood vessels,” says Dr. Shtein. “There is a great deal of interest now in medications used to treat excessive blood vessels in retinal diseases like diabetic retinopathy and wet macular degeneration. Perhaps these drugs, with some modification, could one day help reduce the risk of corneal transplant rejection,” she adds.

Screening for Diabetes with Retinal Imaging “Snapshots” of the eyes may give early warning of diabetes and related eye disease A new vision screening device could give physicians and patients a head start on treating diabetes and its vision complications. The instrument, invented by two Kellogg scientists, captures images of the eye that show metabolic stress and the tissue damage that occur before the first symptoms of disease are evident. The camera-like instrument can detect this damage earlier than any current clinical method. For people with diabetes — diagnosed or not — the new device could offer potentially significant advantages over blood glucose testing, the “gold standard” for diabetes detection. It is non-invasive and takes about five minutes to scan both eyes. Used as a firstline screening test, the device would indicate whether a patient should proceed with additional testing. In the July issue of Archives of Ophthalmology, Victor M. Elner, M.D., Ph.D., and Howard R. Petty, Ph.D., report on the potential of the new instrument to screen for diabetes. “Technology that can detect the earliest signs of diabetes gives us a new way to tackle a growing public health concern,” says Dr. Elner. “Early detection and treatment are critical in controlling the disease and its many complications.” He points out that 24 million Americans have diabetes and an additional 57 million have abnormal blood sugar levels that qualify as prediabetes. Some of these individuals will develop diabetic retinopathy, an eye disease that affects 4.1 million people and can cause blindness. The instrument can detect metabolic stress, and therefore disease, by measuring the intensity of cellular fluorescence in retinal tissue. This is the second study in which Drs. Petty and Elner reported that high levels of flavoprotein autofluorescence (FA) are reliable indicators of eye disease. Dr. Petty, a biophysicist and imaging expert, explains that hyperglycemia — or high blood sugar —

Dr. Petty and Dr. Elner review data suggesting early signs of diabetes.

is known to induce cell death in diabetic tissue soon after the onset of disease but before symptoms can be detected clinically. “Increased FA activity is the earliest indicator that cell death has occurred and tissue is beginning to break down,” says Dr. Petty. People with diabetes might take better care of themselves once they receive results from this kind of testing, suggests Dr. Petty. “A patient who understands that body tissue is being destroyed may be newly motivated to step up efforts to manage the disease,” he says. “Technology that can In the study, Drs. Elner and Petty measured FA levels detect the earliest signs of 21 individuals with diabeof diabetes gives us a new tes and compared the results to age-matched healthy way to tackle a growing controls. The Kellogg scientists found that FA activity public health concern.” was significantly higher for those with diabetes, regard— Victor M. elner, M.D., Ph.d. less of severity, compared to those who did not have the disease. Similarly, individuals with diabetic retinopathy had much higher FA activity compared to diabetic patients without any visible eye disease. The study also suggests that FA levels can be used to monitor the severity of the disease and the ability of treatments to stem tissue damage. Dr. Elner is a Research to Prevent Blindness Senior Scientific Investigator. The researchers have formed a company, OcuSciences, Inc., to commercialize the metabolic imaging instrument.

Accelerating Research

“As important as it is to look for new methods, if we just concentrate on getting people to come for the treatments we have, we can save a lot of vision.” — Joshua D. Stein, M.D., M.S.

Trends in health care emerge from claims data One troubling finding: many with glaucoma are not receiving treatment It appears that many older adults are not getting the treatment they need for a common form of glaucoma, according to a recent study. And perhaps more troubling, the data suggest that both nonwhite and lowincome individuals are less likely to receive treatment. For glaucoma specialist and author of the study Joshua D. Stein, M.D., M.S., these numbers are disturbing. Prompt and sustained treatment is essential for preventing loss of vision from glaucoma, a group of “There’s a wealth of eye diseases causing damage information available to the optic nerve. Once damage occurs, vision loss in these data sets. We cannot be restored. The findings come from just need to tap into an analysis of a database with information on serthe data, make sense vices provided to Medicare of the patterns, and, beneficiaries over a ten-year period, from 1992 to 2002. ultimately, use the Dr. Stein and his colleagues identified 6400 individuals, information to improve all 65 years of age or older, care for our patients.” who had received a diagnosis of primary open-angle — Joshua D. Stein, M.D., M.S. glaucoma (POAG). The most common form of glaucoma, POAG can silently and progressively destroy vision before symptoms are noticed. The study is one of several of Dr. Stein’s research projects in which he analyzes data from large health care databases to flesh out patterns of health care. For example, by studying large groups he can determine how frequently people use medical services, which medications are prescribed for them, which tests have been ordered, and other factors important in shaping health policy. “There’s a wealth of information available in these data sets,” he explains. “We just need to tap into 8

university of michigan kellogg eye center

Dr. Stein crunched the numbers in a national database to learn more about glaucoma treatment.

the data, make sense of the patterns, and, ultimately, use the information to improve care for our patients.” The current study, published in Ophthalmology, reported that nearly 30 percent of patients with glaucoma received neither medical nor surgical treatment. Dr. Stein further observed that those with Medicaid, a program for needy and low-income individuals, were 43 percent less likely to receive care for glaucoma. Another troubling statistic, he added, is that Hispanics, Asians and patients from other minority groups were all less likely than non-Hispanic whites to receive treatment. Now, says Dr. Stein, we need further studies to explain why these individuals aren’t receiving proper medical care. “Is access to health care the biggest problem, or is cost the obstacle? Perhaps there are barriers to communication,” he says. The answers to these questions could help more people with glaucoma get the care they need. The study also examined which glaucoma drugs are most frequently prescribed. And Dr. Stein says there is always debate about new and preferred treatments. But, he adds, “As important as it is to look for new glaucoma therapies, if we could just concentrate on getting people to take advantage of the treatments we already have, we would save a lot of vision.”

Consortium seeks answers on RP Is there more than one way to rescue a photoreceptor? Scientists and physicians from three universities are teaming up to develop therapies for an inherited retinal degenerative eye disease. Funded by the Foundation Fighting Blindness (FFB), the project brings together the best minds from various disciplines and perspectives to collaborate on treatments for X-linked retinitis pigmentosa (XLRP). A patient with XLRP has generously underwritten the research. Together the team will explore a variety of therapeutic approaches, all intended to replace or rescue dying photoreceptors. Of the seven team members, five are from the U-M Kellogg Eye Center. Collaboration is becoming an increasingly favored approach in research, says Debra A. Thompson, Ph.D., who will direct one section of the study. She points to recent results of a small study in which patients regained some vision after receiving gene therapy for a degenerative eye disease. “With this stunning success for patients with the RPE65 mutation, we now have evidence that similar approaches could work for a larger group of patients whose vision is compromised by other genetic mutations.” Retinitis pigmentosa is a group of diseases that cause slow but progressive loss of vision usually over decades. The designation “X-linked” means that the mutation responsible for the disease is carried on the X chromosome. Simply stated, this disorder results in the loss of photoreceptors, the rods and cones responsible for vision. Scientists who make up the FFB Consortium will explore different strategies for restoring the function of photoreceptors and preventing their loss. The project initially centers on a mouse model of XLRP identified by Kellogg’s John R. Heckenlively, M.D., in collaboration with the Jackson Laboratory. The model, known as rd9, has the same gene and type of mutations as seen in humans with XLRP. Using this mouse model, Hemant Khanna, Ph.D., and David N. Zacks, M.D., Ph.D., will explore whether cell-replacement therapy is an effective strategy for restoring lost vision. They will transplant healthy photoreceptor rods into the retinas of the diseased mice, with the goal of achieving at least partial recovery of

Hemant Khanna, Ph.D., John Heckenlively, M.D., David Zacks, M.D., Ph.D., (standing) and Naheed Khan, Ph.D., Debra Thompson, Ph.D., (seated) are on the Michigan team studying retinitis pigmentosa.

the rods’ ability to function. This builds on the work of Anand Swaroop, Ph.D., now a senior scientist at the National Eye Institute, whose work at Kellogg led to successful transplantation of rod precursor cells into blind mice in 2006. Dr. Swaroop, whose lab identified a key mutation in the RPGR gene, was the driving force behind the creation of the Consortium. Taking another tack, researchers at the University of Pennsylvania and the University of Florida will seek to repair photoreceptor damage by delivering therapeutic or “healthy” forms of the RPGR gene into the retina. They will investigate strategies using modified viruses that act as vectors to carry a replacement copy of the affected gene. The replacement genetic material was constructed at Kellogg by Dr. Khanna’s laboratory. While gene delivery using viral vectors has been successful in treating certain degenerative eye diseases, Kellogg’s Dr. Thompson observes that there are still lingering concerns about the safety of the approach. She is exploring alternate methods, involving the delivery into the eye of small molecules expected to rescue failing photoreceptor physiology affected by the RPGR mutation. Dr. Heckenlively, who sees patients with a range of inherited retinal diseases, and whose project found over 100 mouse models of human eye disease, will evaluate the effectiveness of each approach. Dr. Heckenlively will review fundus photographs and ERG recordings to see how close each approach has come to the collective goal of rescuing photoreceptors. Accelerating Research

Investing in Education By expanding our educational and training programs, we attract the best and brightest residents, clinical fellows, and postdoctoral research fellows. They go on to careers in ophthalmology and vision science, serving as leaders here and around the world.

Christine C. Nelson, M.D. and Raymond Cho, M.D.

“I am particularly grateful for the time and effort which all of the faculty continually invest in my development as an oculoplastic surgeon.” — Raymond Cho, M.D.

Kellogg Fellow is Battle Tested Physician who served in Iraq comes to Kellogg to hone his ophthalmic plastic surgery skills Lieutenant Colonel Raymond Cho, M.D. served in Iraq from November 2005 through April 2006. During that time, more than 90 percent of Dr. Cho’s patients were trauma victims — soldiers and civilians with ruptured eyes, facial fractures, and soft tissue trauma. After an intense time repairing eye damage caused by roadside bombs and improvised explosive devices, Dr. Cho came to Kellogg in 2007 to advance his clinical and surgical skills. He is now Kellogg’s fellow on the Eye Plastic, Orbital and Facial Cosmetic Surgery Service. Kellogg’s fellowship programs, among the best in the nation, allow physicians to train in a clinical program known for depth and excellence in each subspecialty. During the two-year oculoplastics program, fellows gain extensive experience in diagnosis, surgical management, pre- and postoperative care and management of patients with eye plastic and orbital disorders and diseases. “This fellowship at Kellogg has been a perfect fit for me,” says Dr. Cho. “I am particularly grateful for the time and effort which all of the faculty continually invest in my development as an oculoplastic surgeon. It has been an excellent program which will undoubtedly prepare me for the cases I will see in the future.” That training has included unusual and complex cases referred to Kellogg from far and wide. Dr. Cho’s mentors and colleagues at Kellogg are quick to praise him. “He is a compassionate physician, superb surgeon and has a humanitarian outlook,” says Christine C. Nelson, M.D., associate professor. “He is an inspiration to us all. His calm demeanor is refreshing, he is a pleasure to work with, and he is a wonderful teacher and mentor to the residents.” Before coming to Kellogg, Dr. Cho chose to follow the path of his father and brother and enrolled in the United States Military Academy at West Point for his

undergraduate degree. The Ohio native went on to the University of Cincinnati for medical school and completed his surgical internship at Brooke Army Medical Center in San Antonio. He then spent three years in the 82nd Airborne Division at Fort Bragg, North Carolina. He returned to Brooke for his residency, after which he was assigned first to Fort Knox, Kentucky, and later to West Point. As the only ophthalmologist at these military bases, Dr. Cho handled a variety of cases. “Working as the lone ophthalmologist taught me valuable organizational skills and helped me build a strong base in ophthalmology before moving on to a subspecialty,” says Dr. Cho. When the military introduced its Warfighter Refractive Eye Surgery Program in 2001, Dr. Cho’s ophthalmology repertoire expanded. He started a laser surgery program both at Fort Knox and at West Point. Once Dr. Cho completes his fellowship at Kellogg in 2009, he will go to one of the Army’s academic medical centers to train residents and handle the oculoplastics needs of the Army, including reconstructive eye surgeries for soldiers returning from combat.

West Point graduate, Dr. Raymond Cho, served in Iraq before joining Kellogg for his two-year ophthalmic plastics fellowship.

investing in EDUCATION

RetinaDx Goes Live An educational web site also invites dialogue Looking back at their residency training, most ophthalmologists remember, somewhat fondly, the “fluorescein conference” as an effective way to learn about retinal diseases. At professional meetings, retina specialists have found the same kind of forum to be among the most popular and thought-provoking. Physicians present interesting cases of retinal disease and then engage in animated discussions on possible diagnoses and treatments. David N. Zacks, M.D., Ph.D., a retina specialist at the Kellogg Eye Center, is creating the same spirit on a new web site — RetinaDx — with nearly 140 retina cases accompanied by spectacular images. For each case there is a brief history and presentation of findings, followed by retina photographs and diagnostic images and “So often physicians see studies. In addition to the diagnosis and the differena rare, isolated case and tial diagnosis, key teaching points — that is, “take would benefit by talking home” messages that can with others who have be applied when the physician encounters patients encountered the same.” with similar symptoms — are included. Each case also has — David N. Zacks, M.D., Ph.D. a section where users can post their comments. Dr. Zacks’ original intent was to create an educational site for medical students, residents and retina fellows. He believed that a comprehensive review of retina cases would be especially helpful during their training or when studying for Boards. But as the site evolved he envisioned yet another use — a forum where specialists could share insights and problem cases. “So often physicians see a rare, isolated case and would benefit by talking with others who have encountered the same,” he says. “Now they can submit the one-of-a-kind case and invite comments from their peers.”

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Dr. Zacks created a web program where doctors can review complex retinal cases, as well as submit their own.

An additional unforeseen benefit is the ease with which physicians will be able to collaborate on publications. As clusters of cases on rare conditions appear on RetinaDx, the contributing doctors could seek out each other and collaborate on case reports for ophthalmology journals. The site has grown since fall 2005 when Dr. Zacks first asked residents to submit cases during their rotation in Kellogg’s Retina Clinic. As favorable feedback came in, Dr. Zacks sought ways to make the site bigger and better. He reached out to his colleagues in other ophthalmology departments and has gathered an impressive Advisory Board. With feedback from the Board and users of the site, he expects RetinaDx to generate discussion and serve as a central gathering place for the retina community. Students, trainees and ophthalmologists are encouraged to view the site and to join in the discussion by offering feedback and posting comments on cases at www.kellogg.umich.edu/retinadx.

This fundus photograph shows the uncommon combination of choroidal neovascularization, angioid streaks and optic nerve head drusen that led to the diagnosis of pseudoxanthoma elasticum.

“We have one of the top residency programs in the country, and enhancing our teaching environment will help us build on that.” — Shahzad I. Mian, M.D.

A Center for Excellence Kellogg expansion leads to dedicated, high-tech space for residents With a goal of providing the best possible education to future ophthalmologists, the Department’s residency training program is designing a new 2,000-square-foot center that will feature state-of-the-art educational and communications technology as well as spaces to learn and interact with colleagues. “This project will create a cohesive, comprehensive space for resident education, and that’s important,” says Residency Director Shahzad I. Mian, M.D. “We have one of the top residency programs in the country, and enhancing our teaching environment will help us build on that. We are bringing together resources and technology that will enable residents to get the most out of their training here.” The Resident Education Center, which will be housed on the sixth floor of the current Kellogg Eye Center tower, will include: • A large conference room equipped with a variety of communication technologies and flexible furnishings that will accommodate conference table, classroom, or lecture-style seating • A surgical skills laboratory and surgery simulator • A pathology teaching laboratory

• Laboratory space for research and educational training • A residents lounge and work area • Close proximity to Kellogg’s John W. Henderson Library and to the residency program’s administrative offices “The teaching part of this center, including the surgical skills laboratory and surgery simulator, will be very helpful during all aspects of a resident’s training,” says Sunir J. Garg, M.D., who completed his training at Kellogg in 2002 and now serves on the Department’s Alumni Advisory Board. He is an assistant professor of ophthalmology at Wills Eye Hospital in Philadelphia. “Faculty members always appreciate when residents invest time in their own surgical development and research efforts.” The new center also includes a comfortable space for independent study or small group meetings as well as space for rest during on-call duty. The residents lounge will have a direct video link to Kellogg’s operating rooms, so residents can view surgeries at any time, without having to add traffic to the operating room environment. “Part of the experience of a residency is making friends with your classmates, many of whom you will see at meetings for the next 35 years,” Dr. Garg says. “Having a place to congregate as a group, both to trade notes on diagnostic and surgical techniques, and to have a chance to relax, makes training that much more memorable.”

Newly designed space for residents and fellows can be adapted for a variety of learning experiences and will include state-of-the-art instructional laboratories.

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Alums Care for Children Worldwide Residents and fellows who train at the Kellogg Eye Center see a wide range of challenging pediatric cases. The experience enables them to gain the skills they need to treat childhood eye diseases in rural and urban areas in the United States and around the world. Those profiled here offer a snapshot of that impact.

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hip complete a fellows ore to Michigan to ap ng Si e om us fr ca ng be o mi Le Co r Dr. nter wasn’t easy fo at the Kellogg Eye Ce inical and surgical cl e th t mily ties. Bu fa d an k while, or rw pe pa of rt more than worth fo ef e th de ma d ne experience she gai tric ophthalmology ore, she leads a pedia ap ng a Si In . ys sa e sh Healthcare Group, ce for the National rvi se y jo us en I ism “ rab le. st op d pe an s 3 million rve se at th y tit en re y public health ca ung ones, who reall pecially the very yo at tre d an e os gn helping patients, es to dia or’s clinical acumen at ion sit po ic depend on the doct academ . Leo also holds an them,” she says. Dr e. or ap ity of Sing the National Univers

Advancing Patient Care Our patients have come to expect exceptional care and access to the newest and best treatments for eye disease. At Kellogg they will find doctors who are leaders in their subspecialties and who also have time to offer a smile and words of encouragement.

Erika M. Levin, M.D.

Getting It Straightened Out Pediatric ophthalmologist improves the vision of Kellogg’s youngest patients No parents want to hear that their child needs surgery. However, when a child has strabismus — a visual disorder in which the eyes are misaligned and point in different directions — sometimes surgery is the only treatment that works. Such was the case for Derek and Rebecca Najarian and their 21-month-old daughter, Olivia, from Pinckney, Michigan. “It was the first surgery on our first child and we were scared,” says Mrs. Najarian. “But Dr. Levin treated us well every step of the way. She answered every question and explained each step of the process. We grew more and more comfortable, and, in the end, she really put our minds at ease.” Erika M. Levin, M.D., a pediatric ophthalmologist at Kellogg, first saw Olivia in May 2003, when she was just 16 months old. Olivia’s pediatrician noticed the strabismus at her 15-month well-child visit and referred her to Dr. Levin in Kellogg’s Brighton office. “When I first met Olivia, she was crying,” says Dr. Levin. “I wasn’t sure if she was nervous or scared, but we were able to work through the tears. I sang to her, worked quickly and we got the job done.” Even though Olivia was too young to read an eye chart, Dr. Levin was able to examine her using finger puppets, mechanical toys and other equipment. Olivia had esotropia (inward turning of the eyes), amblyopia (a “lazy eye” or poorly-seeing eye) and some far-sightedness. Dr. Levin first recommended glasses because they can sometimes help straighten the eyes in children with esotropia and farsightedness. This was not the case with Olivia. Dr. Levin also patched Olivia’s stronger eye to strengthen the vision in her weaker eye. Once her vision was equal and her misalignment was stable, Olivia was ready for surgery. The goal in treating strabismus — a condition affecting 4 percent of children in the United States — is to straighten the eyes so they can be used together. With normal alignment, both eyes aim at the same spot. When one eye is out of alignment, two different images are sent to the brain. While adults would suffer from double vision, a child’s brain simply ignores the image from the misaligned eye. Correcting the misalignment

Dr. Levin heard “proof positve” of the successful surgery. When Olivia and her parents went to Disney World, her improved vision allowed Olivia to see Mickey Mouse “jump” out of the 3-D movie and greet the children.

early increases the chances of developing or regaining stereoscopic vision. If glasses aren’t effective, surgery — or a combination of glasses and surgery — is recommended. In September 2003, “It was the first surgery when Olivia was 21 months old, she underwent successon our first child and ful strabismus surgery with Dr. Levin repositioning her we were scared. But inner eye muscles. She went Dr. Levin treated us home the same day, without any special bandages well every step of the or patches, and returned to normal activities within a way, and, in the end, few days. Two months later, she really put our minds Olivia’s eyes were perfectly aligned. Her amblyopia at ease.” hadn’t returned so she didn’t require further patching. — Ms. Rebecca Najarian Now, at 6 years old, Olivia sees 20/30 in each eye without glasses and her eyes remain straight. She returns to Kellogg once a year for a follow-up appointment, a visit Dr. Levin eagerly awaits. “One of the best things about being a pediatric ophthalmologist is seeing patients like Olivia grow and develop over the years,” says Dr. Levin. “It’s so rewarding to know that I’ve had a positive impact on my patients’ lives and on their families’ lives, too. I’m thrilled I can do that for them.” advancing Patient care

The Road to Independence Low Vision Clinic helps patients make the most of their limited vision In 1992, Jeff Crawford came to the U-M Kellogg Eye Center’s Low Vision Clinic with one goal: he wanted to improve his vision so he could earn his driver’s license. He was tired of taking the bus or relying on family and friends to drive him where he needed to go. After working with low vision specialist Donna M. Wicker, O.D., Mr. Crawford achieved his goal and — at age 28 — obtained his first license. He promptly bought a bright yellow Jeep Wrangler. “I figured that if I had any trouble seeing other drivers, at least they would be able to see me,” Mr. Crawford says, laughing. Kellogg’s Low Vision Clinic helps patients with vision loss ranging from mild impairment to legal blindness. These people typically suffer from macular degeneration, diabetic retinopathy, glaucoma and retinitis pigmentosa. Mr. Crawford is typical of many patients with low vision — a term that denotes vision that is 20/70 or less with the best conventional glasses prescription. Many come to their first appointment with specific goals, such as improving their ability to tackle tasks like meal preparation, reading, driving, writing checks and paying bills. “When patients come to our clinic, we discuss specific tasks they would like to accomplish or the ones that give them trouble,” explains Dr. Wicker. “Our job then is to test their vision and optimize their remaining functional vision with the use of optical devices, electronic devices and training techniques.” What patients need most are devices that can magnify the objects and material they encounter every day. Among these are high-power reading glasses, telescopes, and handheld and stand magnifiers. Other devices include special telephones and modified closed circuit televisions that enlarge reading material and project it onto a TV monitor. Non-optical devices include largeprint items and talking clocks and watches. It was the telescope that allowed Mr. Crawford to get that first driver’s license. Because he is legally blind due to congenital cataracts and aniridia (an absent or partially absent iris), he uses bioptic telescopes — minia18

university of michigan kellogg eye center

Jeff Crawford credits Dr. Wicker for helping him live and work on his own terms.

ture telescopes attached to the top of his eyeglasses — to help him drive. The low vision specialists see about 20 patients each week, most referred by Kellogg’s clinics and community offices. “Kellogg embraces a multi-disciplinary approach to the treatment of low vision,” explains Dr. Wicker. “We have a team of ophthalmologists, optometrists and occupational therapists working together to meet each patient’s needs.” A low vision patient typically has one to four appointments. The last is an optional in-home visit by occupational therapist Karen Murphy, who helps patients with lighting, safety, contrast and organization. Mr. Crawford, now 44, returns to Kellogg each year for a check-up with his ophthalmologist and sees Dr. Wicker if his vision has changed. “Dr. Wicker and the low vision staff are very professional and friendly and always are concerned about your well-being,” says Mr. Crawford. “The honesty and integrity at Kellogg are phenomenal.” Thanks to Kellogg, Mr. Crawford can drive to his job of 14 years. He is a machine operator for Edwards Brothers, a book and journal manufacturing company in Ann Arbor. “Kellogg gave me back my freedom and independence,” he states, proudly.

Reconstructing the Orbit — and a Young Boy’s Future Oculoplastics service built on teamwork, tough cases Taiwo Bilesanmi, now a teenager, lost his eye to cancer when he was just one year old and living in Nigeria. His family did not have access to a surgeon who could rebuild the child’s orbit, the bones and muscles that form the eye’s support. The proper supporting structure was essential if Taiwo were, one day, to have a new prosthetic eye created for him. Reconstructive surgery can make a big difference in people’s lives, observes Kellogg oculoplastic surgeon Alon Kahana, M.D., Ph.D. At first, Taiwo was too young to care about the loss of his eye, according to his father. But as he grew older, he became sensitive to comments from his friends about his appearance. By the time Taiwo came to the Kellogg Eye Center for orbital reconstruction, the young boy was anxious, but ready for surgery that would allow him to have a new eye. Dr. Kahana was aware the surgery would not be simple. Taiwo, whose family now lives in Detroit, had gone for some 12 years without an eye or prosthesis, and as a result, the orbit had become malformed. Much of the supporting tissue was lost, and the bony structure had grown inward, displacing a silicone implant from an earlier surgery and making it impossible to fit a prosthetic eye. There was one more obstacle, this one concerned with safety. Before Dr. Kahana would consider surgery, he insisted that Taiwo begin to wear polycarbonate glasses. Like his Kellogg colleagues, Dr. Kahana tells his patients they must protect their “good” eye with shatter-resistant lenses. Dr. Kahana then presented his plan: replace the earlier implant with tissue from Taiwo’s thigh to create the supporting structure. There are several techniques a surgeon can use to reshape the orbit, and many nuances in performing the surgery, says Dr. Kahana. “The ultimate goal is to have good reconstruction that is long lasting and allows for a good prosthetic fit,” he says. “Orbital reconstruction can be easy to do but hard to do well.” After surgery, Dr. Kahana was pleased at last to see a smile on his patient’s face. “I think he finally could

see the light at the end of the tunnel,” says Dr. Kahana. Then Taiwo went on to see Gregory Dootz, Kellogg’s ocularist who has been creating and fitting prosthetic eyes for Kellogg patients for some 29 years. One of three surgeons on Kellogg’s Eye Plastic, Orbital and Facial Cosmetic Surgery service, Dr. Kahana credits his colleagues with having built a strong practice that serves as a major referral center for “Orbital reconstruction difficult eye plastic surgery. Then too, there is the forecan be easy to do but sight of recently retired service chief, Bartley R. Frueh, hard to do well.” M.D., who came to the Department to start the Eye — Alon Kahana, M.D., Ph.D. Plastic Service nearly thirty years ago. One of his early decisions was to hire Gregory Dootz, says Dr. Kahana. “Dr. Frueh was an accomplished surgeon who knew that to do orbital reconstruction well it was essential to have an expert ocularist on staff and then work together as a team.” Despite many doctor’s appointments and surgeries, Taiwo is very positive. His father offered strong encouragement, and Taiwo, now 15 years of age, says, “It was easy except for the surgery. It’s all OK now.”

Taiwo Bilesanmi at a follow-up visit with Dr. Kahana. advancing Patient care

On the Road Again Big Ten eye doctors go to Vietnam In March, five-year-old Vee, who lives in a small village outside Da Nang, Vietnam, had surgery to correct a tendency for his eyes to turn inward and upward. Vee’s surgeon was pediatric ophthalmologist Monte A. Del Monte, M.D., who had come to Vietnam with ORBIS, an organization that brings a Flying Eye Hospital and ophthalmologists to countries where eye care and modern techniques are scarce. There was added commotion, as cameras followed Vee and Dr. Del Monte to film a televised special featuring ophthalmologists from Big Ten universities teaching local ophthalmologists and providing surgical treatment in developing countries. Michigan was represented Training local doctors is by Dr. Del Monte and alumnus Keith C. Carter, vital in a country like M.D., who completed his residency at Kellogg and Vietnam where just 10 today is chair of the Univerophthalmologists are sity of Iowa’s Department of Ophthalmology. available per million By the end of the week, Dr. Del Monte had people. performed 15 surgeries on children and adults with strabismus, a condition in which the eyes are not properly aligned. His young patient Vee had a form of strabismus called esotropia with overacting inferior oblique muscles, causing inward turning or crossing and vertical upshooting of his eyes, the most common condition Dr. Del Monte saw during his stay in Da Nang. At the heart of ORBIS is the goal of training local doctors, nurses, and other health workers in state-ofthe-art ophthalmic diagnostic and surgical techniques. This is vital in a country like Vietnam where just 10 ophthalmologists are available per million people. Assisted by a local ophthalmologist during Vee’s surgery, Dr. Del Monte was able to demonstrate a new surgical technique, a stitchless self-closing incision underneath the eyelid in a way that eliminates external stitches. “It is very comfortable for the patient, but technically more difficult for the surgeon,” says

university of michigan kellogg eye center

Representatives from the Big Ten on the tarmack in Da Nang: Keith Carter, M.D., Derek Del Monte, M.D., Wanda Martinez, M.D., Monte Del Monte, M.D., and Hua Gao, M.D., Ph.D.

Dr. Del Monte. “But when we use this technique, we see kids opening their eyes and smiling immediately after surgery. They have less pain, and they can be outside playing the next day.” Sure enough, when Dr. Del Monte visited Vee in his home after the surgery, the young boy was doing just fine, playing with a friend. When not performing surgery, Dr. Del Monte lectured to ophthalmologists who had come from all over the country. Again stressing its educational mission, ORBIS asks volunteer physicians to bring several educational lectures when they travel. Dr. Del Monte has participated in a number of international programs, but this one had special meaning for him. His son, Derek, who completed his medical training at Michigan and is now a first-year ophthalmology resident at Duke University, accompanied him on the trip. “The experience sold him on the excitement and rewards of international ophthalmology, and in a few years I expect to see him pursue the ORBIS program for third-year residents.” “One of the greatest rewards is that the families are so grateful,” adds Dr. Del Monte. “You know how frightened the patients are before surgery, and then you see big smiles on their faces after they become aware of the results.” Dr. Del Monte was especially touched by a unique personal gift he received from several of his patients’ families: an intricately carved marble tray, dragon pitcher and matching cups, each engraved with the name of one of his surgical patients. Dr. Del Monte will be featured in a televised special to air this fall. Check our web site for details.

“You know how frightened the patients are before surgery, and then you see big smiles on their faces after they become aware of the results.” — Monte A. Del Monte, M.D.

Dr. Del Monte teaching local ophthalmologists in the O.R.

Hua Imperial Palace, Hua, Vietnam.

Dr. Carter examines a patient’s x-ray.

Five-year-old Vee before his surgery.

Vee and his parents after his surgery.

Sanpan water taxi, Hoi An, Vietnam.

Dr. Del Monte with his local trainees: Dr. Ngoc, Dr. Huang, and Dr. Tan.

Celebrating Philanthropy By endowing professorships, providing support for expansion, and making annual gifts to research, individuals and foundations are helping the Kellogg Eye Center reach new levels of excellence.

university of michigan kellogg eye center

Victor M. Elner, M.D., Ph.D.

Endowing a Legacy Ophthalmic pathologist Dr. Victor Elner honored as Ravitz Foundation establishes a professorship that recognizes a little-known specialty When Detroit native Edward Ravitz began a Foundation to help improve the health of his fellow citizens, he decided to support efforts that sought good over glory, says Burton R. Shifman, president of the Ravitz Foundation. Mr. Shifman and his fellow trustees followed that mission in establishing the Ravitz Foundation Professorship in Ophthalmology and Visual Sciences at the Kellogg Eye Center this year. Victor M. Elner, M.D., Ph.D., is the first to hold the professorship. His specialty of ophthalmic pathology is essential to treating and understanding eye disease, but it receives little notice. There are only ten ophthalmic pathologists in the U.S., working to identify the correct source of disease. “In many ways, it’s a dying area of expertise, and I commend the Ravitz Foundation for recognizing its importance and working to ensure it continues to benefit patients,” Dr. Elner says. As an ophthalmologist and a pathologist, Dr. Elner examines eye tissue to draw connections between the underlying disease process and the most effective approaches to diagnosis and treatment. He plays a central role in training new ophthalmologists. “His appointment as Ravitz Professor will benefit both our Department and the entire field of ophthalmology,” says Paul R. Lichter, chair of the U-M Department of Ophthalmology and Visual Sciences. Dr. Elner has been on the Kellogg faculty since 1988. He received his medical degree, residency training, and fellowship training in pathology from the University of Chicago and completed additional fellowships in pathology and ophthalmic plastic and reconstructive surgery. His research has shown that inflammation is often a cause of eye disease or its complications, and he has described the chain of events that results in the destruction of cells leading to vision loss. He also collaborated with Kellogg scientist Howard R. Petty, Ph.D., in developing a state-of-the-

Taking time to celebrate: Ravitz Foundation board members Lawrence F. Handler, M.D., Bruce D. Gelbaugh, Burton R. Shifman, and Arnold J. Shifman with Kellogg’s Paul R. Lichter, M.D., (center left) and Victor M. Elner, M.D., Ph.D. (center right).

art camera system that detects eye disease long before the first symptoms occur (see p. 7). Dr. Elner’s clinical specialties include the evaluation and treatment of eyelid and orbital tumors, thyroid eye disease and disorders affecting the eyelid and tear ducts. He has published more than 150 articles on pathologic entities and advances in eye plastic surgery. Mr. Ravitz, a businessman who oversaw the building of more than 25,000 single-family homes and apartments in Michigan and other states, would have appreciated the steady, groundbreaking progress Dr. Elner has made. From his hardworking immigrant parents, Mr. Ravitz learned ethics and responsibility. He became a decorated combat army officer in World War II, after which he overcame many obstacles in building a company that ultimately grew to 600 individuals. Though Mr. Ravitz passed away in 1999, his Foundation continues to pursue his vision of supporting medical research and initiatives that eliminate prejudice and further a sense of community and shared humanity. At U-M, gifts from the Ravitz Foundation have established a professorship in the U-M Department of Pediatrics and Communicable Diseases and the Ravitz Foundation Phase 1 / Translational Research Center at the U-M Comprehensive Cancer Center. The Foundation has also supported C.S. Mott Children’s Hospital, the U-M Depression Center, the Medical School, the School of Public Health, the Dental School, the Department of Molecular and Integrative Physiology, and the Division of Kinesiology. Celebrating philanthropy

A New Era of Pediatric Eye Care The Carls Foundation Pediatric Ophthalmology Clinic will have more space, resources to help children battle eye disease and trauma Children with vision problems come from throughout Michigan and around the world to see pediatric ophthalmologists at the Kellogg Eye Center. Those physicians will be able to care for even more young patients when the addition, which will house the new Carls Foundation Pediatric Ophthalmology Clinic, opens in the spring of 2010. “We are nearly dou“We are nearly doubling bling the space we devote to children’s eye care and the space we devote to to pediatric vision research and training programs,” children’s eye care and to says Monte A. Del Monte, pediatric vision research M.D., Skillman Professor of Pediatric Ophthalmology and training programs.” and a Professor of Pediatrics and Communicable — Monte A. Del Monte, M.D. Diseases. The Carls Foundation, based in Detroit, is proud to be a part of the effort. The Foundation has pledged $2 million to support the expansion and sees the mission of the pediatric ophthalmology clinic as very close to its own, says Executive Director Elizabeth A. Stieg. “One of our main goals is to help make children’s lives better, and we understand how important it is to correct a child’s vision problems as early as possible.” The new 4,000-square-foot clinic will be on the first floor of the Kellogg addition and will include 10 examination rooms, each with the required 22-foot examination lane needed to accurately measure a child’s eye alignment. The clinic will also be equipped with advanced diagnostic technology as well as a special 24

university of michigan kellogg eye center

procedures room, a clinical trials and digital imaging room, and a multi-media patient education room where families can learn more about eye diseases. The new space will enable Kellogg to recruit two additional academic pediatric ophthalmologists who will see patients and conduct research. Kellogg faculty members today study conditions such as childhood glaucoma, retinopathy of prematurity, intraocular lens placement in children, thyroid-associated eye disease and strabismus, and many other vision diseases that affect children. Scientific breakthroughs were important to Detroit industrialist William Carls, who started the Foundation in 1961 with his wife, Marie Carls. They had lost a child in infancy and became interested in helping children receive the best possible medical care, Ms. Stieg says. Mr. Carls took an active role in directing the grants of the Foundation until his death in 1995. “He was a wonderful man, and he enjoyed seeing what resources matched with expertise could accomplish in a community,” says Ms. Stieg. “He liked to see things happen.” An engineer by training, Mr. Carls was particularly interested in building projects and technology, she says. The Carls Foundation today supports pediatric health facilities and programs throughout the state, as well as youth activity programs and the preservation of natural areas and historic buildings. At the University of Michigan, the Carls Foundation has also supported William Carls the Mott Children’s Hospital construction, a diagnostic and treatment program for children at risk for profound hearing loss, and research in the area of jaw-related birth defects.

the Eye Center Expansion makes rapid progress New building will help us improve the lives of our patients and achieve new levels of excellence in research and education On a blustery November day, friends, faculty, alumni, and staff gathered to celebrate another milestone in the Kellogg Eye Center expansion. The “Topping Out” ceremony marks completion of the major structural steel in a construction project, and the safety of the crew who worked on it. The traditional signing of the last beam took place during the morning and, later in the day, the Kellogg community gathered to watch and cheer as the beam was hoisted to the top of the building. Since that day work has continued with great speed. As the internal structure of this adjoining building takes shape, we can begin to see just how much space we will gain. The 8-story building will provide 230,000 square feet of additional space, allowing each of Kellogg’s seven clinics to expand patient care, as well as offer patients larger and more comfortable waiting areas. The facility will also include new surgical suites, new and innovative research space, and a unique diabetes research center: the Delores S. and William K. Brehm Center for Type 1 Diabetes Research and Analysis. This substantial increase in space means that we can recruit new faculty who, together with current faculty, will make the Department a formidable force in ophthalmology and the visual sciences. The educational benefits for our fellows, residents, and vision scientists will be immeasurable. The Eye Center will serve many more patients, and will be known as a destination for those seeking the most advanced care available. New research laboratories will accelerate progress toward treatments for debilitating eye disease. “Our essential mission is clear,” says Department Chair Paul R. Lichter, M.D. “We will discover treatments and cures to improve the lives of our patients. With growth and new resources, and the dedicated support from friends, we can offer hope to patients and their families that cures for eye disease and blindness are just ahead.”

The view looking south from Broadway.

The view from the park in back of the building.

Helmut Stern, Larry Miller, Carolyn Lichter, Marian Poling, Harold “Red” Poling, Paul Lichter, M.D., Doug Strong, and Perry Schechtman gather just before the Topping Out ceremony. Celebrating philanthropy

Kellogg Eye Center Expansion Honor Roll

We thank the following individuals for making gifts and multi-year pledges in support of the construction of the new Kellogg Eye Center building.

$2 million and up Carls Foundation Edwin E. and Mary U. Meader Larry G. Miller

$1,000,000 to $1,999,999 Lynn H. and Robert W. Browne, D.D.S. Richard and Jane Manoogian Foundation Harold A. and Marian L. Poling Helmut Stern Robert and Ellen Thompson The Harry A. and Margaret D. Towsley Foundation

$500,000 to $999,999 John F. and Casilda Daly

$250,000 to $499,999 Mickey and Karen Shapiro Timothy and Laurie G. Wadhams

$100,000 to $249,999 Anonymous Donor Frank J. and Helga Arnold Charles and Rita Gelman Johnson Controls Foundation Carolyn and Paul Lichter Keith and Della McKenzie Dr. Charles L. and Kathleen K. Smith David and Jayne VerLee Mary June and William Wilkinson

$50,000 to $99,999 Steven and Constance Benz Anne and Terry J. Bergstrom Dave and Yvette Bing Thomas C. Brown

university of michigan kellogg eye center

James and Martha Conrad William and Carol Cutler Gloria P. and William E. Dean, Jr. Ruth B. Dixon Robert and Cassandra Estes Douglas P. and Shelley Felt Vincent R. and Joyce McLean James and Nancy Ravin Rennie and Michael Roth Alan and Gail Sugar

$25,000 to $49,999 Anonymous Donor ~ 2 James and Kathryn Adams Herbert and Carol Amster Harry and Patricia Bash Joe and Beth Fitzsimmons Richard and Lisa Garfinkel Larry and Mary Gerbens James T. and Charlene L. Glerum Orpha Irwin Helen and Richard Kerr Kim Lindenmuth and Matthew Bueche Roger Meyer and Judy Gordon John and Phyllis Napley Michael Petersen and Elizabeth Binasio Helen and Earl Schaper

$10,000 to $24,999 Alfred Berkowitz Foundation Seth Bonder George and Connie Cress Dow Chemical Company Foundation Ann and Joseph W. Edwards Robert G. Fante, M.D. David Gavrin Harry C. Gibson, M.D. E. Paul and Lillian Gieser

Richard F. Gutow John R. Heckenlively Virginia Hickman Robert and Joan Hughes KALSEC Corporation W.R. Kenley Robert and Mary Kiess James G. and Carolyn Knaggs Carol L. Makielski and Charles D. Lake Donald and Jacqueline McCulloch Dean and Lynn Mitchell Andrew and Cathryn Moyes Stanley and June Oleksy U.E. Patrick Sally J. Pryce James R. Quinn Michael and Debra Raizman James D. and Helene C. Reader Franklin and Marilyn Sassaman Perry and Faith Schechtman Michael and Linda Smith-Wheelock Susan and David Thoms Alfred and Carol Wick W. Scott and Jill Wilkinson

$5,000 to $9,999 Everton and Saundrett Arrindell Nancy Bender Donald and Christine Beser Robert D. and Jennie P. Biggs Garry and Gretchen Binegar Fred and Miriam Blum Ralph and Kay Crew Andrew and Margaret Hanzlik Dr. and Mrs. John W. Henderson Peter and Karla Hitchcock Mark and Linda Johnson Metaldyne New England Eye Center Venkat and Alvira Reddy H. Kaz Soong and Barbara Nevins-Soong Danny D. Wang and Yili Wang

$1,000 to $4,999 Steven and Carol Archer James and Martha Barnett Edward and Martha Boggs William and Julie Bromley

Bruce Cameron Bill and Janet Cassebaum Mark and Judith Cohen Barb and Wayne Cornblath Deborah M. Cox Monte A. and Kristen G. Del Monte Gayle D. Dickerson Thomas and Susan Essman Francis Falck Judith FitzGerald and Robert Glinert Philip Gage and Wendy Rampson-Gage Dasa and Nalini Gangadhar Carol and Edward George Jon and Sarah Gieser Robert Goldsmith Daniel and Norma Green Robert O. and Carolyn S. Hoffman Bret and Laura Hughes David and Patricia Johnson Robert Keil Key Foundation Kirk and Constance Lignell Bernard L. Maas Foundation James Albert Maraldo Marvin Joe and Beverly McKenney Shahzad Mian and Uzma Ahmad Sayoko Moroi and Mike Fetters Christine Nelson and Willis Lillard Betsy and Ken Nisbet Mohammad and J. Elizabeth Othman Mark and Kimberly Phelan Sheryl and Douglas Podlewski Donald and Debra Puro Julia Richards and Carl Marrs Gary and Diana Sandall Marcia and David Schmidt Tara Schmitt and Christopher Palumbo Carol and Irving Smokler Carol L. Standardi Richard and Joyce Toner Peter and Adele Vaculik Margaret Vezina Richard L. Wacksman Randall S. and William K. Wallach Richard and Kay Watnick Adrienne West and Mark Hemmila

$500 to $999 William and Elizabeth Arendshorst Eric Arnold Frederick and Jean Birkhill Steven and Jacqueline Boskovich Christina Bruno MargaretAnn Cross and James Van Fleteren Carolyn and David Diles Gregory and Dottie Dootz Jerome and Polly Finkelstein Martin and Elaine Goode June and R. James Harvey William Hawkins Reid and Donna Johnson Richard Alan and Patricia N. Lewis Richard Rodman and Patrice Bouzan-Rodman Stephen and Kim Saxe Warren and Nancy Scherer Barney and Geraldine Schwartz Atta Rae and Gabriel Sitrin E.H. Newel and Rosemary Smith Thomas and Jane Stratford Scott E. Szalay Debra Thompson and William Strong James B. Thompson Jeanne K. Walters Ronald E. Warwar, M.D. Margaret B. White Beverly Yashar and John Mesberg David Zacks and Susan Harris

up to $499 Cynthia Abejuro Katherine Augustaitis Mike Bergiel Samir and Mona Binno Renee Blosser Carolyn and Leonard Bohm Marcia J. Boynton Lisa Burkhart and Frank Hunt James W. and Nola Cavett Beverly A. Conkle Marlene and Paul Dodge Donna M. Duffy Hal and Donna Estry Darlene C. Fero

Elena Filippova Jacqueline A. Forrest Bruce and Susan Furr Chad and Courtney Godfrey Dr. and Mrs. Edward F. Hall Theodore and Naomi Harrison Margaret Hartz Joseph and Lori Hymes Walter Ingram Robert and Joan Jampel Laura E. Kakuk-Atkins Athanasios J. Karoukis Adabelle Knief Judith Knitter Piyush and Sarla Kothary Susan L. Lichter Michael and Judy Lipson Susan Ludwig Steven Manikas James and Gay McGuckin Midwest Transmission, Inc. Donald and Barbara Mitrzyk Victor and Kendra Monroe David and Benita Murrel Dr. Dave and Jan Musch Ajay Natarajan and Ritu Khanna Olga Nelson Gale and Yehuda Oren Hemant Pawar Rebecca and Paul Pazkowski Carol J. Pollack-Rundle and Family Frank Rozsa and Szonja Puskas-Rozsa Ross and Shannan Saltz Cindy Shaffran Susan and Gary Simpson Camille S. Smith Jeanne F. Smith Becky and Doug Spaly Amy Steele Norma and Gene Stohler Anand and Manju Swaroop Pat and John Tongusi Jonathan Trobe and Joan Lowenstein Molly and Robert Wheaton Alyce Whipp Kim Wisniewski Anthony Wojciechowski Jennifer Ziehm-Scott Celebrating philanthropy

A New Image Photography faculty and staff look forward to the creation of the Harry A. and Margaret D. Towsley Ophthalmic Imaging Center With more than 70 years of combined experience in medical photography, the faculty and staff of the Harry A. and Margaret D. Towsley Ophthalmic Imaging Center are preparing to make the most of their new space when the addition to the Kellogg Eye Center The Ophthalmic Photography staff who will occupy the new Towsley Imaging Center: opens in 2010. Robert Prusak, Richard Rice, Richard Hackel (Director), and Linda Goings. The Harry A. and Margaret D. Towsley Foundation has agreed to make a $1.5 million grant to the Kellogg Eye important to diagnosing and treating disease, as well Center expansion campaign and will name the as for research and teaching purposes. Kellogg photogophthalmic imaging center. The gift builds on the raphers have also worked with Drs. Howard R. Petty Towsley family’s longtime support of vision care and Victor M. Elner to develop a camera that can detect at the University of Michigan. eye disease in its earliest stages. “It is a family tradition to be involved with the “Our new space will be conducive to those kinds Kellogg Eye Center, but more importantly we are of projects, and we are looking forward to doing more thrilled and excited about the work they are doing research,” says Richard E. Hackel, Director of Ophthaltoday,” says Margaret Ann Riecker, Chairperson of mic Photography and assistant professor in the U-M the Foundation and one of Harry and Margaret School of Art. Towsley’s daughters. Supporting medical progress is a priority of the The center will be completely digital, allowing Towsley Foundation. “The whole idea of good science photos to be a central part of Kellogg’s new electronic and research is so important to health care, and the medical record. It will feature individual procedure University of Michigan is certainly the place for that,” rooms for patients and will be located on the second says Mrs. Riecker. floor near the retina and glaucoma clinics, two subspe Both Harry and Margaret Towsley were graduates cialties that use photography services the most. of U-M. Harry Towsley, M.D., served the U-M as pro “The new space will be better for patients because fessor of pediatrics and chairman of the post-graduate of its proximity to the clinics, and it will encourage medicine department. The Towsley Foundation’s widemore communication between physicians and our ranging support at U-M has included leadership gifts staff,” says ophthalmic photographer Linda Goings. toward the construction of the Charles R. Walgreen, Jr. Ophthalmic photographers at Kellogg are involved Drama Center and the Athletic Department’s Stephen in patient care as well as research. They use special M. Ross Academic Center, as well as to the Harry A. equipment to take photos of the retina, cornea, and and Margaret Towsley Policymaker in Residence proother parts of the interior of the eye as well as perform gram in the Gerald R. Ford School of Public Policy. dye- and laser-based testing. Images of the eye are

university of michigan kellogg eye center

Annual Giving Propels Vision Research Forward Fralick Society recognizes donors who partner with Kellogg Discovering how the brain processes visual information, how zebrafish repair their own retinas, and what takes place when cells essential to sight begin dying — these are all areas of research that were supported by contributions to the Kellogg Eye Center’s annual funds this year. The Annual Fund and the Alumni and Faculty Annual Fund are the cornerstones of the philanthropic giving that helps Kellogg fulfill its mission. As unrestricted research funds, they support the most innovative and promising studies, sustain strong research programs between grants, and provide extra resources to projects in key stages of discovery. To recognize and celebrate annual gifts to research of $100 or more, Kellogg has created the F. Bruce Fralick Society. Named in honor of the Department’s fifth chair, the Society sponsors an annual luncheon where Chair Paul R. Lichter, M.D., and other faculty members share news of scientific advancements. The forum provides an opportunity for donors to interact with scientists and to meet one another. Members who support Kellogg’s programs at the Benefactor level ($1,000 or more) or above are also invited to special tours of our research laboratories. More than 600 individuals are members of the Fralick Society, including many alumni.

Chairman F. Bruce Fralick, M.D., broadened the mission of the Department to include investigations into the basic science of sight.

Fralick Professor Paul R. Lichter, M.D., Receives Top Ophthalmology Award Paul R. Lichter, M.D., received the Lucien Howe Medal from the American Ophthalmological Society (AOS) for his distinguished service to ophthalmology. The Howe Medal, first awarded in 1922, is one of the highest honors in the field of ophthalmology. Dr. Lichter is Chair and F. Bruce Fralick Professor of the U-M Department of Ophthalmology and Visual Sciences. He is also Director of the W.K. Kellogg Eye Center. Recipients of the Howe Medal are “individuals who have made powerful marks on our ophthalmic heritage,” said Dennis J. Robertson, M.D., Professor Emeritus of Ophthalmology at the Mayo Medical School, who presented the award on behalf of the AOS. He cited Dr. Lichter’s service to professional organizations, his pivotal role in clinical studies involving patients with glaucoma, and his research on the genetics of glaucoma. “His leadership and tenacity helped spearhead a number of studies, including one that was uniquely dear to his heart, involving quality-of-life issues among glaucoma patients,” said Dr. Robertson. Dr. Lichter’s leadership and vision have left their mark on every important ophthalmological organization, beginning with the American Academy of Ophthalmology (AAO), which he served as President during its centennial year. However, his influence on policies was also felt in other organizations where he was president, from the Association of University Professors of Ophthalmology to the Pan American Association of Ophthalmology. Dr. Lichter was recognized for having authored over 200 publications and for giving numerous named lectures. He served as Editor-in-Chief of the AAO’s journal, Ophthalmology, and on editorial boards of several major journals. Dr. Robertson noted that Dr. Lichter wrote many “thought-provoking editorials” and was never afraid to take on a controversial issue. Celebrating philanthropy

Annual Honor Roll of Donors With heartfelt thanks to donors who made gifts from July 1, 2007, to June 30, 2008. Included in this listing are contributors whose donations are part of multi-year pledges. $500,000 to $999,999 The Holmes family: Kristin, Jay, Kathy, and Jim

The Foundation Fighting Blindness The Ravitz Foundation

$100,000 to $499,999

Couple Makes Research a Priority Hope and empowerment are behind the enthusiasm with which Jim and Kathy Holmes support vision research. “Giving is a way for us to do something active to fight eye disease, and because such wonderful research is being done, we are able to hope for the future,” says Mrs. Holmes.

She and her son have retinitis pig-

mentosa, an inherited disease that causes the degeneration of light-sensing rod and cone cells. While she has vision difficulties associated with the condition, she believes the progress being made will help her son.

Mrs. Holmes began coming to the

Kellogg Eye Center in her mid-20s. “Kellogg has been a blessing,” she says. Mr. and Mrs. Holmes make annual gifts to the laboratory of David N. Zacks, M.D., Ph.D., a clinician–scientist who studies the biological chain of events that results in the death of rod and cone cells.

“As Jim and I were able to make gifts,

we decided to set priorities, and eye research was at the top of the list,” says Mrs. Holmes. “Vision is a gift. We would like to see more treatments and cures, and we want to do what we can toward that goal.”

university of michigan kellogg eye center

Edward T. and Ellen K. Dryer Charitable Foundation International Retinal Research Foundation Richard and Jane Manoogian Foundation Larry G. Miller Harold A. and Marian L. Poling Elmer and Sylvia Sramek Charitable Foundation

$50,000 to $99,999 Brian P. and Mary Lincoln Campbell Gloria P. and William E. Dean, Jr. Michael A. Wainstock, M.D. Mary June Wilkinson

$10,000 to $49,999 Anonymous donor Nancy Bender Adena D. Butler Jean E. Craig Ann and Joseph W. Edwards Rita Jane Edwards Estate Robert and Cassandra Estes Douglas P. and Shelley Felt Elaine Frick Bartley and Cheryl Frueh Muhieddine Ghandour and Hala Jaroudi James T. and Charlene L. Glerum Richard F. Gutow Velma E. Harness Intralase Corporation W.R. Kenley Raul Philip Martinez Keith and Della McKenzie Vincent R. and Joyce McLean Joel and Susan Mindel National Glaucoma Research Sally J. Pryce James and Nancy Ravin Roberta W. Siegel Virginia L. Sivacek Mildred E. Swanson Foundation Helen M. Taylor

Betty and Stanley J. Thomson Timothy and Laurie G. Wadhams

$5,000 to $9,999 Anonymous donor Harry and Patricia Bash Frank and Barbara Batsch Michael and Joanne Bisson Scott M. Corin and Nina Blumenthal Fairfield Corporation Emeline N. Falls Richard and Lisa Garfinkel Frances and David H. Grossman Gary Gutow John R. Heckenlively Pege Harvey-Matthews Barry and Mary Ann Hoffman Helen and Richard Kerr James G. and Carolyn Knaggs Michael Petersen and Elizabeth Binasio Marian A. and Edwin C. Schilling, Jr. Barbara and Anthony Stone Alan and Gail Sugar

$1,000 to $4,999 James and Kathryn Adams Ann Arbor Area Community Foundation Steven and Carol Archer Everton and Saundrett Arrindell Anne and Terry J. Bergstrom Robert D. and Jennie P. Biggs Garry N. Binegar, M.D. Fred and Miriam Blum Henry A. Boldt, Jr., M.D. Thomas W. Breakey Jason M. Burgett, M.D. Keith D. and Cheryl D. Carter Janet and Bill Cassebaum Mark and Janet Cichowski Mark and Judith Cohen William and Carol Cutler Monte A. and Kristen G. Del Monte J. McGregor and Christine Dodds Frances Dupont Frederick E. Dupont, Jr. Robert G. Fante, M.D. Fight for Sight Margaret E. Gallup Larry and Mary Gerbens E. Paul and Lillian Gieser Joanne R. Gradowski Robert and Teresa Grosserode Kenneth Alan Haller William P. Haney, M.D. Robert O. and Carolyn S. Hoffman Kathy and Jim Holmes Bret and Laura Hughes

Walter and Barbara Hungerford Mrs. Virjean Johnson Jeffrey A. Kahn Keith and Susan Kobet Carolyn and Paul Lichter William W. Love Dr. Marvin and Sue Lubeck James Albert Maraldo Jean Beyst-Martonyi and Csaba L. Martonyi Donald and Jacqueline McCulloch Marvin Joe and Beverly McKenney Corey A. Miller, M.D., and Nancy J. Miller Dean and Lynn Mitchell Kenneth H. Musson and Patricia Musson Bruce L. and Roberta Oliver P & G Fund Michael and Karen Pachtman Mark and Kimberly Phelan Scott M. Pinter, M.D. Venkat and Alvira Reddy Gary S. Sandall Franklin and Marilyn Sassaman Perry and Faith Schechtman Marcia and David Schmidt Donald H. Schriver Alan and Sandra Schwartz Alene M. Smith Charles and Kathleen Smith Michael and Linda Smith-Wheelock H. Kaz Soong and Barbara Nevins-Soong Peter K. Speert Triford Foundation Gerald M. Trocchio David and Jayne VerLee Andrew Vine and Caroline Blane Genevieve E. Walinski Herbert E. Weston George C. Whitaker Marina V.N. and Robert F. Whitman W. Scott and Jill Wilkinson

$500 to $999 Gerald and Gloria Abrams Roger D. Arnett Edward and Martha Boggs James and Jacqueline Bowen William and Julie Bromley Christine R. Buse Ruth F. Clarke Theresa M. Cooney, M.D. Deborah M. Cox Morton S. Cox Damon’s Grill Roland and Louise W. DeMartin Gayle D. Dickerson

M. Kenneth and Arvene Dickstein Dow Chemical Company Foundation John S. Dunn Magdalen Skuba Edwards Shawn F. Fagan John N. Fetters Ralph M. Fox Philip Gage and Wendy Rampson-Gage Dasa and Nalini Gangadhar Harry C. Gibson, M.D. Waleed K. Gosaynie Henry E. and Kathryn G. Gray Adele Gudes Froncie Gutman Theodore and Naomi Harrison June and R. James Harvey Dr. and Mrs. John W. Henderson Gerald W. Heppler Joyce D. Herron James A. Johnson Mark and Linda Johnson Maureen S. Kennelly Richard and Lucille King C. Byron Landis, M.D. Jean E. Lewis Richard Alan Lewis and Patricia N. Lewis Harry and Eva McGee Mary Ann and P. Anthony Meza Elaine J. Mickelson Betsy and Ken Nisbet Patrick J. and Bonnie K. Parden Elizabeth M. Potter Estate Ann M. Reed John Wallace Risk Paul Rizzo Robert Roosenberg, M.D. Charles Sherman Carol L. Standardi Richard and Joyce Toner Myrna Tumaneng James F. Vander Richard L. Wacksman Ronald E. Warwar, M.D. Marion T. Wirick

$100 to $499 Ann T. Alexander J. Gregg and Dorothy E. Arbaugh Charles R. Ashcraft Charles and Nancy Bagnasco Deane and Marilyn Baker I. Josephine Ballert Lawrence A. Barnes James and Martha Barnett Philip Barrons

Alum Is Proud to Support Growth When Larry J. Gerbens, M.D., finished his ophthalmology residency at the University of Michigan in 1978, the program was well respected but small. To watch it evolve into one of the top residency programs in the country has been exciting, he says. “I’m very proud of what I have seen happen.”

The generosity of Dr. Gerbens and

his wife, Mary, has helped support the Department’s growth over the years. They contributed to the initial building campaign for the Kellogg Eye Center in the early 1980s, and they made a gift to the current expansion effort. They also contribute to the Alumni Annual Fund for research, which Dr. Gerbens co-chaired this year, and they have included the Kellogg Eye Center in their estate plans. Dr. Gerbens is also a member of the Alumni Advisory Board.

“Philanthropy has always been very

important to us,” he says. “There’s a real joy that comes from giving.”

Dr. Gerbens is grateful for his train-

ing, which enabled him to earn a good living and help so many of his patients, he says. He practiced general and pediatric ophthalmology for years in Grand Rapids before retiring this past spring.

“This institution gave me the chance to

become an ophthalmologist, to enjoy the success that brings, and to develop a skill that I could use to help others,” he says. “It provided many opportunities for me and for my family.”

Celebrating philanthropy

Donald F. Baty, Jr. James C. Beachum Roy W. Beck Lois Bereza Dr. and Mrs. W.G. Bergen Rhoda L. and Roger M. Berkowitz Thomas A. Bersani and Joan Christy Mary Lee Beuerle Mike Bishel and Clarita Guerrero-Bishel Myrtle B. Bonem Stephen Boorstein, M.D. Nancy S. Boutell Daniel L. Braden Carl A. Brauer, Jr. Betty Jean Brown Jeremy and Barbara Brown Margaret C. Brown Wilbur and Carolyn Burkett Irving F. Burton Donald V. Calamia Carola Caroselli James W. Cavett William and Marilyn Chandler Anne M. Chase Lillian V. Choate Joan M. Christy Hideki and Tomomi Chuman Marilyn L. Citron Shirley CoeBeck and David Beck Donald L. Cole Clare R. Coles Carl and Maria Constant Patrick J. Coppens Ellen L. Coulthard MargaretAnn Cross and James Van Fleteren Speers M. Crumrine Lyubica Dabich James E. Davies William and Virginia Dawson Delta Gamma Fraternity Ann Arbor James R. Devine Helen DeWolfe Norma Diamond Marlene and Paul Dodge Donald A. Dodick Richard and Patricia Donahey Gregory and Dottie Dootz Mr. and Mrs. Kenneth R. Dornbrook Donna M. Duffy Cathlynn Duncan and George Watson Mrs. Lois A. Dyer Ms. Alice Engibous Bita Esmaeli-Gutstein, M.D. Hal and Donna Estry Blaine and Jean Evans

university of michigan kellogg eye center

Barbara Fazio Mrs. M. J. Feener Bryn A. and Suzanne M. Fick Carol and Paul Finch Jerome and Polly Finkelstein Dennis and Christine Fornal Jacqueline A. Forrest Stephen and Rosamund Forrest Ralph N. Funk Charles A. Gallup Patricia M. Gardner Sunir J. Garg, M.D. General Motors Foundation Carol and Edward George David and Sylvia Good Anitra and Jesse Gordon Star Guest Besondy and Margaret Hagen Jane Hakken Charlotte Hanson Hugh and Janet Harness Laurelynne D. Harris Michael and Carolyn Harris Helen F. Hatch Ruth Heyn, M.D. Frederick J. Heyner Milton and Geraldine Higgs Carolyn and Larry Hiss Richard and Jane Hiss Charles F. Hoitash Janet Woods Hoobler John and Barbara Hoshaw Hsin-Hong Huang Christy Bole Hughes Bernice E. Hyne Illinois Tool Works Foundation Johnson Controls Foundation Mr. and Mrs. Kenneth B. Johnson S. Preston and Betty B. Jones George H. Jury Daniel and Rose Kachnowski Jill Taft Kaufman Robert B. Kaufman, M.D. Rosemary S. Kaye Kelloggâ&#x20AC;&#x2122;s Corporate Citizenship Fund Michael A. Kipp, M.D. Robert and Toby Kleinberg William L. and Betty G. Knapp J. David Kotre Mrs. Harry Krashen Tommy Kromer Gerald and Dorothy Kurtz Marie Lane Louis and Gail LaRiche Gloria A. Lehman Jeanne M. Lerchen

Danute Leveckis and Timothy VanEvery Bobbie and Myron Levine Robertson A. Lewis Susan L. Lichter Kim Lindenmuth and Matthew Bueche Thomas J. Long Dr. A. Letitia Loveless Helen Price Luckham Raymond W. Lumley Angelo Maeso Steven Manikas Edna F. Manns Terrence and Joyce McCool Donna Rita McNally Donald and Diane Meitz Professor George E. Mendenhall Carolyn E. Mesara Robert and Margery Mesler Herbert R. Metzger Mary L. Meyer William M. Michaluk Helen Mitchell Ms. Marlene M. Moleski Sayoko Moroi and Mike Fetters Jock Morrison Richard G. Mosteller Dr. and Mrs. Joseph Mottillo Dr. Patrick J. and Mrs. Jacquelyn P. Mulrow William J. Mundus Dr. Dave and Jan Musch Dr. Michel and Alice Nasif Christine Nelson and Willis Lillard Jonathon P. Niemczak Edward Nishon Kenneth E. Oettle Charles I. Ojielo Paul L. Olson Gale and Yehuda Oren John Orr Mohammad and J. Elizabeth Othman Karen L. Pacer Mr. and Mrs. Edmund L. Palmer Harriet Parsons and John Brundage Carol M. Paull Joseph F. Pavka Gordon E. Peckham, Sr. Sheryl and Douglas Podlewski Carol J. Pollack-Rundle and Family Rebecca and Eric Priebe Donald and Debra Puro Drs. Douglas J. and Leslie E. Quint William M. Redfield Mr. and Mrs. Walter F. Redmond Robert and Alice Reisig Charles S. Remenar

Rita and Robert Reske Thomas R. Riggs Mr. and Mrs. Arthur C. Rocco Horace and Yvonne Rodgers Carl D. Roe Lucille and Harold Roper K.J. and P.J. Roper Rose Metal Recycling Beverly L. Rosenthal Rennie and Michael Roth Jonathan A. Rowe, M.D., and Robin L. Rowe Jim and Joan Rucker Majed and Rheame Sahouri Loretta D. Sammet Stephen and Kim Saxe John and Dorothy Schaefer Helen and Earl Schaper Larry and Barbara Scherer Leonard T. Schmidt Eileen Schott John and Karen Schultz Ruth I. Segura David and Elvera Shappirio Mrs. Lorraine M. Sheppard Paul and Pam Sieving Pauline Skinner Slauson Middle School PTSO E.H. Newel and Rosemary Smith Jeanne F. Smith Kenneth S. Smith Sue-Ellen Smith Becky and Doug Spaly Walter and Nesta Spink Mr. and Mrs. John Strand Thomas and Jane Stratford Joel Sugar and Anita Gerber James P. and Dorothy Symons Scott E. Szalay F. Brian Talbot John and Joan Tedford Dewey Tennent Edward and Karen Tenner Roger C. Thibault Karen and Michael Thomas James B. Thompson Edward Thornhill A. Richard Tischler Pat and John Tongusi Margaret J. Tuomari Nelly S. Ullman Frank Veres Claudia M. Wagner David R. Wagner A. Phyllis Wallace Sidney Warschausky and Lorraine Nadelman

Joyce Muriel Weber Lee S. Webster Carol and Jack Weigel Carolyn Jean Weigle Dr. and Mrs. William W. Wells Sue and Kenneth Wenrich-Bucholz Avis L. White Dr. Patrick T. and Mary White E. Suzanne and Keith Williams Jean A. and Richard C. Wilson Jeneane Wise Ford L. Wright Michael and Kathleen Yang Dr. Wen-Jei Yang Harry and Miriam Yukelson Henry and Dorothy Zelisse Jennifer Ziehm-Scott Jeff and Kate Zink Thomas and Delle ZurSchmiede

In Memory Of The Kellogg Eye Center is honored to have received gifts in memory of the following individuals. James Daniel Benore Fred Church Patrick Mathew Davis III Fred E. Dupont Jane G. Elliott Sylvia Goode Pailoon Jevaharian Dr. Kemmick Marjorie McDonald Edward W. Meyer Charles F. Moore, Sr. Madeline Pellerin Eileen Perault Harold A. Roper Madeline L. Vantine Dorothy Jane Williams Betty Yendall

In Honor Of The following individuals were honored through gifts to the Kellogg Eye Center. Monte A. Del Monte, M.D. Ernest and Linda Dunn Jerome I. Finkelstein, M.D., FACS F. Bruce Fralick, M.D. Martin Goode, D.D.S. John R. Heckenlively, M.D. Walter Hungerford Ida L. Iacobucci, C.O. Paul R. Lichter, M.D., FACS

Shahzad I. Mian, M.D. Sayoko E. Moroi, M.D., Ph.D. Stephen J. Saxe, M.D., FACS K. P. Sogoian Manufacturing and its employees Gabriella Stone Susan S. Thoms, M.D. Andrew K. Vine, M.D. David N. Zacks, M.D., Ph.D.

Bequests and Other Planned Gifts It is with deep gratitude that we recognize the following individuals for making the Kellogg Eye Center a part of their estate plans. Frank J. and Helga Arnold Nancy Bender Anne S. Benninghoff Rhoda L. and Roger M. Berkowitz Robert D. Biggs, M.D. Ruth F. Clarke Gloria P. and William E. Dean, Jr. Ralph M. Fox Helen A. (Poorbaugh) Freedman Larry and Mary Gerbens Ed and Sue Gorney Ida Lucy Iacobucci Mrs. Harry Krashen Harry and Eva McGee Marvin Joe and Beverly McKenney Bruce L. and Roberta Oliver Mrs. Shirley M. Schaible William Selezinka, M.D. E.H. Newel and Rosemary Smith Russell A. Stephens and Phyllis A. Capogna David and Jayne VerLee Michael A. Wainstock, M.D. Jean A. and Richard C. Wilson

Only those who gave their permission are included above. If you have a bequest and were not contacted, please call us at 734-615-0243. Special Thanks With appreciation to Myron Hepner and Delta Gamma Fraternity for their volunteer fundraising activities. We make every effort to ensure the honor roll is as accurate as possible. Please let us know if you note any errors.

Celebrating philanthropy

Faculty honors, recognition, and publications Steven M. Archer, M.D. Awards/Honors/Leadership • Best Doctors in America • Election to the Squint Club Publications Wolf AB, Yang MB, Archer SM. Postoperative myositis in reoperated extraocular muscles. J AAPOS 2007;11:373-6. Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. Surv Ophthalmol 2007;52:474-82. Garg SJ, Archer SM. Consecutive cyclic exotropia after surgery for adult-onset cyclic esotropia. J AAPOS 2007;11:412-3. Eibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA . Current concepts in the management of concomitant exodeviations. Comp Ophthalmol Update 2007;8:213-23. Peters ER, Archer SM. Long-standing, largeangle exotropia in adults. Am Orthoptic J 2007;57:104-6. Archer SM. Monocular diplopia due to spherocylindrical refractive errors. Trans Am Ophthalmol Soc 2007;105:252-71. Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens implant power prediction formulas in pediatric patients. J AAPOS 2008;12:173-6. Trzcinka A, Moroi S, Soans FP, Archer SM. Late-onset Haemophilus influenzae endophthalmitis in an immunized child following Baerveldt implant. J AAPOS 2008 [in press].

Radha Ayyagari, Ph.D. Grants see grants, page 44 Awards/Honors/Leadership • Scientific Advisory Board Member, Foundation Fighting Blindness • Reviewer, Foundation Fighting Blindness • Member, Steering Committee, National Ophthalmic Diagnostic Genotyping Network (eyeGENE), National Eye Institute, NIH Publications Reddy GBB, Satyanarayana A, Balakrishna N, Ayyagari R, Padma M, Viswanath K, Petrash JM. Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy. Mol Vision 2008;14:593-601. Yzer S, Zonneveld M, Lopez I, Ayyagari R, Teye-Botchway L, van den Born LI, MotaVieira L, Cremers FPM, Koenekoop RK. Phenotypic and molecular analysis of a family with three sibs affected by severe autosomal recessive retinitis pigmentosa and a second cousin affected by Stargardt macular dystrophy. Mol Vision 2007;13:1568-72. 34

Roberts DK, Ayyagari R, Moroi SE. Possible association between long anterior lens zonules and plateau iris configuration. J Glaucoma 2008 (in press).

Elner VM, Park S, Cornblath W, Hackel R, Petty HR. Flavoprotein autofluorescence detection of early ocular dysfunction. Arch Ophthalmol 2008;126:259-60.

Grant M. Comer, M.D.

Cornblath WT. Optic pathway glioma. In: Kashii S, ed. Ophthalmology: Clinical NeuroOphthalmology. Kanehara & Co., 2008, pp. 330-2.

Awards/Honors/Leadership • 2007 Kellogg Eye Center Resident Teaching Award Publications Huynh TH, Johnson MW, Comer GM, Fish D. Vitreous penetration of orally administered valacyclovir. Am J Ophthalmol 2008;145:682-6. Chong DY, Comer GM, Trobe JD. Optic disc edema, cystoid macular edema, and elevated vascular endothelial growth factor in a POEMS syndrome patient. J Neuro-Ophthalmol 2007;27:180-3. Comer GM, Johnson MW. Coats’ Disease and Retinal Telangiectasia. In: Albert, Miller, Azar, Blodi, eds, Albert and Jakobiec’s Principles and Practice of Ophthalmology, 3rd ed. Philadelphia, PA: Elsevier, 2008

Theresa M. Cooney, M.D. Awards/Honors/Leadership • Representative of the Michigan Society of Eye Physicians and Surgeons to the Michigan State Medical Society Publications Cooney TM, Johnson CS, Elner VM. Keratomalacia due to psychiatric-induced dietary restrictions [Case Report]. Cornea 2007;26:995-7.

Wayne T. Cornblath, M.D. Awards/Honors/Leadership • Best Doctors in America • Member, Education Liaison Committee, American Academy of Ophthalmology • Co-moderator, Management of Common Neuro-Ophthalmic Conditions: Critical Initial Steps in Management - 2007 AAO Neuroophthalmolgy Symposium • Director, Double or Nothing – Diplopia Diagnosis & Management. Indian Health Service Biennial Eye Care Conference • Director, Visual Field Loss with Anatomic Correlation. Indian Health Service Biennial Eye Care Conference • Director, Now You See It, Now You Know It: Pathognomonic Signs. Indian Health Service Biennial Eye Care Conference • Director, Anisocoria. Indian Health Service Biennial Eye Care Conference Publications Stephens T, Parmar H, Cornblath W. Giant tumefactive perivascular spaces [short communication]. J Neurol Sci 2008;266:171-3.

university of michigan kellogg eye center

Cornblath WT. Optic nerve sheath meningioma In: Kashii S, ed. Ophthalmology: Clinical Neuro-Ophthalmology. Kanehara & Co., 2008, pp. 322-5. Sisson JC, Schipper MJ, Nelson CC, Cornblath WT, Freitas JE, Frueh BR. Radioiodine therapy and thyroid eye disease. J Nuc Medicine 2008;49:923-30. Margolin E, Cornblath W, Hackel R. Retinal vasculitis due to systemic lupus erythematosus. Arch Ophthalmol 2008;126:126.

Monte A. Del Monte, M.D. Grants see grants, page 44 Awards/Honors/Leadership • Best Doctors in America • Special Invited Guest Speaker, III Congresso Brasileiro de Estrabismo e Ophthalmologia Pediatrica, IV Congresso Nacional de Oftalmologia da SBO, Rio de Janeiro, Brazil • David Friendly Award and Lecturer, Costenbader Pediatric Ophthalmology Society • Special Invited Guest Lecturer, 57th Annual Postgraduate Course, Syracuse University • Chairman, Program Committee, American Orthoptic Council • Chairman, International Affairs Committee, American Association for Pediatric Ophthalmology and Strabismus • Review Panel, Journal of Pediatric Ophthalmology and Strabismus • Medical Advisory Board, Knight’s Templar Eye Research Foundation Outreach • ORBIS International Flying Eye Hospital, Pediatric Visiting Professor and Mentor, Big Ten Challenge, Da Nang Eye Hospital, Da Nang, Vietnam Publications Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. Surv Ophthalmol 2007;52:474-82. Del Monte MA, O’Keefe M, Johnson A. Immediate postoperative strabismus management. J Pediatr Ophthalmol Strab 2007;44:330-2.

Faculty honors, recognition, and publications Kemper AR, Gurney JG, Eibschitz-Tsimhoni M, Del Monte MA. Corrective lens wear among adolescents: findings from the National Health and Nutrition Examination Survey. J Pediatr Ophthalmol Strabismus 2007;44:356-62. Eibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA. Current concepts in the management of concomitant exodeviations. Compr Ophthalmol Update 2007;8:213-23. Peters E, Del Monte MA. The pediatric eye examination. In: Reddy V, Greydanus DE, Feinberg AN, et al., eds. Degowin’s The Pediatric Diagnostic Examination, Philadelphia: McGraw Hill, 2007; Chap 7:137-58. Kothary PC, Del Monte MA. Impaired signal transduction in human pigment epithelial cells from patients with age related macular degeneration. Adv Exp Med Biol 2008;613:269-75. Pediatric Eye Disease Investigator Group. Primary treatment of nasolacrimal duct obstruction with probing in children younger than 4 years of age. Ophthalmology 2008;114:577-84. Eibschitz-Tsimhoni M, Archer SA, Del Monte M. Effect of axial length and keratometry measurement error on intraocular lens implant power prediction formulas in pediatric patients. J AAPOS 2008;12:173-6. Del Monte MA. Sturge-Weber syndrome. In: Fraunfelder FT, Roy H, eds. Current Ocular Therapy, 6th ed. Philadelphia:Saunders Elsevier 2008; Chap 105:195-9. Furr BA, Del Monte MA. Long-term outcome after surgical treatment for superior oblique palsy. In: Ryndberg A, Stephenson G, van Lammeren M, eds. Reflections on the Diversity of Current Orthoptics. Transactions of the XI International Orthoptic Association Congress. Verantwoordelijke uitgever 2008; pp. 282-5. Del Monte MA. Ocular anatomy and physiology. In: Rudolph C, Lister G, Gershon A, First L, Rudolph A, eds. Rudolph’s Pediatrics, 22nd ed, New York:McGraw-Hill 2008 [in press]. Enzenauer R, Del Monte MA. Strabismus. In: Rudolph C, Lister G, Gershon A, First L, Rudolph A, eds. Rudolph’s Pediatrics, 22nd ed, New York:McGraw-Hill 2008 [in press] Kemper AR, Del Monte MA. Vision screening and interpretation. In: Weitzman M, Tanski S, Garfunkel L, eds. Bright Futures in Practice, Pediatric Preventive Services Manual. San Francisco:American Academy of Pediatrics 2008 [in press].

Jonathan B. Demb, Ph.D. Grants see grants, page 44 Awards/Honors/Leadership • Editorial Board, Journal of Neuroscience • Keynote speaker, European Retina Meeting, Frankfurt Publications Demb JB. Cellular mechanisms for direction selectivity in the retina. Neuron 2007;55:17986. Demb JB, von Gersdorff H. Ultraweak signals can cause synaptic depression and adaptation. Neuron 2008;57:802-4. Manookin MB, Beaudoin DL, Ernst ZR, Flagel LJ, Demb JB. Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight. J Neurosci 2008;28:4136-50.

Maya Eibschitz, M.D. Publications Kemper AR, Gurney JG, Eibschitz-Tsimhoni M, Del Monte MA. Corrective lens wear among adolescents: findings from the National Health and Nutrition Examination Survey. J Pediatr Ophthalmol Strabismus 2007;44:356-62. Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. [Review] Surv Ophthalmol 2007;52:474-82. Eibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA . Current concepts in the management of concomitant exodeviations [Review]. Comp Ophthalmol Update 2007;8:213-23. Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens implant power prediction formulas in pediatric patients. J AAPOS 2008;12:173-6.

Demirci H, Hassan AS, Elner SG, Boehlke C, Elner VM. Comprehensive, combined anterior and transcaruncular orbital approach to medial canthal ligament plication. Ophthalmic Plast Reconstr Surg 2007;23:384-8. Elner SG, Elner VM, Field MG, Park S, Yang D, Heckenlively JR, Petty HR. Retinal flavoprotein autofluorescence as a measure of retinal health. Trans Am Ophthalmol Soc 2008 [in press].

Victor M. Elner, M.D., Ph.D. Grants see grants, page 44 Awards/Honors/Leadership • Best Doctors in America • Ravitz Foundation Professor of Ophthalmology & Visual Sciences • Board of Directors, American Association of Ophthalmic Pathologists Publications Boehlke CS, Frueh BR, Flint A, Elner VM. Malignant fibrous histiocytoma of the lateral conjunctiva and anterior orbit. Ophthalmic Plast Reconstr Surg 2007;23:338-42. Cooney T, Johnson CS, Elner VM. Keratomalacia due to psychiatric-induced dietary restrictions [Case Report]. Cornea 2007;26:995-7. Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462-72. Demirci H, Hassan AS, Elner SG, Boehlke C, Elner VM. Comprehensive, combined anterior and transcaruncular orbital approach to medial canthal ligament plication. Ophthalmic Plast Reconstr Surg 2007;23:384-8. Yen KG, Elner VM, Musch DC, Nelson CC. Periocular versus general anesthesia for ocular enucleation. Ophthalmic Plast Reconstr Surg 2008;1:24-8. Demirci H, Elner VM. Double bicanalicular silicone intubation for management of partial lacrimal drainage obstruction in adults. Ophthalmology 2008;115:383-5.

Susan G. Elner, M.D. Grants see grants, page 44 Awards/Honors/Leadership • Best Doctors in America • Thesis Review Committee, American Ophthalmological Society • Ad hoc member, Neurobiology C, Veterans Affairs Merit Review Committee • Section Editor, Eye Publications Yang D, Elner SG, Bian Z-M, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462-72.

Demirci H, Vine AK, Elner VM. Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma. Ophthalmic Surg Lasers Imaging 2008;39:57-9. Elner VM, Park S, Cornblath W, Hackel R, Petty HR. Flavoprotein autofluorescence detection of early ocular dysfunction. Arch Ophthalmol 2008;126:259-60.

university of michigan kellogg eye center

Faculty honors, recognition, and publications Victor M. Elner, cont’d

Demirci H, Elner VM. Tumors of soft tissue. In: Klintworth GK, Garner A, Heathcote JG, Cameron JD, Elner VM, Rao NA, eds. Garner & Klintworth’s Pathobiology of Ocular Disease. Taylor & Francis, New York 2008. Chap 57, pp. 1371-96. Elner VM. Apoptosis. In: Klintworth GK, Garner A, Heathcote JG, Cameron JD, Elner VM, Rao NA, eds. Garner & Klintworth’s Pathobiology of Ocular Disease. Taylor & Francis, New York 2008. Chap 2, pp.29-45. Hassan AS, Elner VM. Optic Nerve Glioma. In: Tasman W, Jaeger EA, eds. Duane’s Clinical Ophthalmology. Lippincott, Williams & Wilkins, Philadelphia, PA. 2008 [in press].

Scott GR, Frueh BR, Flint A, Elner VM. Fibrous dysplasia of the lacrimal sac. Ophthalmic Plast Reconstr Surg 2008 [in press].

Elner V, Park S, Cornblath W, Hackel R, Petty H. Flavoprotein autofluorescence detection of early ocular dysfunction. Arch Ophthalmol 2008;126:259-60.

Demirci H, Johnson T, Frueh BR, Musch DC, Fullen D, Nelson CC. Management of periocular cutaneous melanoma with a staged excision technique and permanent sections: the “square procedure.” Ophthalmology 2008 [in press].

Field MG, Elner VM, Puro DG, Feuerman J, Musch DC, Pop-Busui R, Hackel R, Heckenlively JR, Petty HR. Rapid, non-invasive detection of diabetes-induced retinal metabolic stress. Arch Ophthalmol 2008 [in press].

Bruce A. Furr, C.O. Awards/Honors/Leadership • President-elect, American Association of Certified Orthoptists

Kahana A, Pribila JT, Nelson CC, Elner VM. Sebaceous cell carcinoma. In: Albert DM, Levin LA, eds, Ocular Disease: Mechanisms and Management. New York:Elsevier, 2008 [in press].

Publications Eibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA. Current concepts in the management of concomitant exodeviations. Comp Ophthalmol Update 2007;8:213-23.

Furr BA, Del Monte MA. Long-term outcome after surgical treatment for superior oblique palsy. In: Ryndberg A, Stephenson G, van Lammeren M, eds. Reflections on the Diversity of Current Orthoptics. Transactions of the XI International Orthoptic Association Congress. Verantwoordelijke uitgever 2008; pp. 282-5.

Shtein RM, Garcia DD, Musch DC, Elner VM. HSV keratitis: histopathologic predictors of corneal allograft complications. Trans Am Ophthalmol Soc 2008 [in press]. Elner SG, Elner VM, Field MG, Park S, Yang D, Heckenlively JR, Petty HR. Retinal flavoprotein autofluorescence as a measure of retinal health. Trans Am Ophthalmol Soc 2008 [in press]. Scott GR, Frueh BR, Flint A, Elner VM. Fibrous dysplasia of the lacrimal sac. Ophthalmic Plast Reconstr Surg 2008 [in press]. Nelson CC, Pribila JT, Elner VM, Flint A, Frueh BR. Carcinoid tumors of the orbit: a clinicopathological review. Graefe’s Arch Clin & Exp Ophth 2008 [in press].

Bartley R. Frueh, M.D. Awards/Honors/Leadership • Best Doctors in America Publications Boehlke CS, Frueh BR, Flint A, Elner VM. Malignant fibrous histiocytoma of the lateral conjunctiva and anterior orbit. Ophthalmic Plast Reconstr Surg 2007;23:338-40. Sisson JC, Schipper MJ, Nelson CC, Corn blath WT, Freitas JE, Frueh BR. Radioiodine therapy and thyroid eye disease. J Nucl Medicine 2008;49:923-30 Nelson CC, Pribila JT, Elner VM, Flint A, Frueh BR. Carcinoid tumors of the orbit: a clinicopathological review. Graefe’s Arch Clin & Exp Ophth 2008 [in press]. 36

Philip J. Gage, Ph.D. Grants see grants, page 44 Publications Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M. Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Circ Res 2008;102:813-22. Gage PJ, Qian M, Wu D, Rosenberg KI. The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol 2008;317:310-24.

Richard E. Hackel, C.R.A. Awards/Honors/Leadership • Section editor,“Blink,” Eyenet • Editorial Board, Journal of Ophthalmic Photography • Editorial Board, Eyenet • Editorial Board, Journal of Neuro Ophthalmology Publications Margolin E, Cornblath W, Hackel R. Retinal vasculitis due to systemic lupus erythematosus. Arch Ophthalmol 2008;126:126.

university of michigan kellogg eye center

John R. Heckenlively, M.D. Grants see grants, page 44 Awards/Honors/Leadership • Best Doctors in America • Associate Editor, Eye • Editorial Board, Documenta Ophthalmologica • Editorial Board, Journal of Ocular Biology • Editorial Board, Diseases and Informatics • Editorial Board, Clinical Ophthalmology Publications Gire AI, Sullivan LS, Bowne SJ, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP. The Gly56Arg mutation in NR2E3 accounts for 1-2% of autosomal dominant retinitis pigmentosa. Mol Vis 2007;13:1970-5. Atmaca-Sonmez P, Khan NW, Heckenlively JR. Hereditary cone dystrophies. In: Albert D, Miller J, Azar D, Blodi B, eds. Principles and Practice of Ophthalmology, Philadelphia:WB Saunders 2008, Chap 178, pp. 2253-60. Atmaca-Sonmez P, Heckenlively JR. Genetic disorders of the retina and optic nerve. In: Garner A, Klintworth G, eds. Pathobiology of Ocular Disease, 3rd ed. Informa Healthcare 2008, Chap 35. pp. 751-84. Chang B, Hawes NL, Davisson MT, Heckenlively JR. Mouse models of RP. In: TombranTink J, Barnstable CJ, eds., Ophthalmology Research: Retinal Degenerations: Biology, Diagnostics, and Therapeutics. Humana Press Inc.:Totowa, NJ 2008, pp. 149-61. Daiger SP, Sullivan LS, Gire AI, Birch DG, Heckenlively JR, Bowne SJ. Mutations in known genes account for 58% of autosomal dominant retinitis pigmentosa (adRP). Adv Exp Med Biol 2008;613:203-9. Heckenlively JR, Ferreyra H. Autoimmune retinopathy: a review and summary. Semin Immunopathol 2008;30:127-34. Shimazaki K, Jirawuthiworavong GV, Heckenlively JR, Gordon LK. Frequency of antiretinal antibodies in normal human serum. J Neuro-Ophthalmol 2008;28:5-11.

Faculty honors, recognition, and publications Small KW, Silva-Garcia R, Udar N, Nguyen EV, Heckenlively JR. New mutation, P575L, in the GUCY2D gene in a family with autosomal dominant progressive cone degeneration. Arch Ophthalmol 2008;126:397-403. Bowne SJ, Sullivan LS, Gire AI, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP. Mutations in the TOPORS gene cause 1% of autosomal dominant retinitis pigmentosa. Mol Vis 2008;14:922-7. Moroi SE, Heckenlively JR. Progress toward personalized medicine for age-related macular degeneration [editorial]. Ophthalmology 2008;115:925-6. Field MG, Elner VM, Puro DG, Feuerman J, Musch DC, Pop-Busui R, Hackel R, Heckenlively JR, Petty HR. Rapid, non-invasive detection of diabetes-induced retinal metabolic stress. Arch Ophthalmol 2008 [in press].

Peter F. Hitchcock, Ph.D. Grants see grants, page 45 Awards/Honors/Leadership • Invited lecturer, Midwest Zebrafish Meeting, Notre Dame, IN • Director, University of Michigan Interdepartmental Neuroscience Graduate Program • Chair (ad hoc), Cell Biology Review Panel • Neurogenesis and Cell Fate Review Panel • Chair (ad hoc) Molecular, Developmental, Cellular Neuroscience Review Panel, NIH

Bret A. Hughes, Ph.D. Grants see grants, page 45 Awards/Honors/Leadership • Member, Special Emphasis Panel, National Eye Institute, NIH • Director, University of Michigan Core Center for Vision Research Publications Yang D, Swaminathan A, Zhang X, Hughes BA. Expression of Kir7.1 and a novel Kir7.1 splice variant in native human retinal pigment epithelium. Exp Eye Res 2008;86:81-91. Hughes BA, Swaminathan A. Modulation of the Kir7.1 potassium channel by extracellular and intracellular pH. Am J Physiol Cell Physiol 2008;294:C423-31. Yang D, Zhang X, Hughes BA. Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium. Exp Eye Res 2008 [in press].

Mark W. Johnson, M.D. Grants see grants, page 45 Awards/Honors/Leadership • Best Doctors in America • Guide to America’s Top Ophthalmologists • Member, Periodic Ophthalmic Review Tests (PORT) Panel, American Board of Ophthalmology • Chairperson, Nominating Committee, Macula Society • William H. Knobloch Lecturer, University of Minnesota, Minneapolis • Moderator, Fluorescein Angiography Conference, Macula Society Annual Meeting, London • Member, Data and Safety Monitoring Committee: Comparison of Age-related Macular Degeneration Treatments Trials (CATT), National Eye Institute, NIH • Editorial Board, American Journal of Ophthalmology • Editorial Board Member, Retina • Editorial Board Member, Retinal Physician Publications Chang TS, Bressler NM, Fine JT, et al, for the MARINA Study Group. Improved visionrelated function after ranibizumab treatment of neovascular age-related macular degeneration: Results of a randomized clinical trial. Arch Ophthalmol 2007;125:1460-70. Wu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration. Clin Ophthalmol 2007;1:157-65. Regillo C, Holekamp N, Johnson MW, Kaiser PK, Schubert H, Schmidt-Efurth U, Spaide R. Retina and Vitreous (Section 12). Basic and Clinical Science Course. San Francisco: American Academy of Ophthalmology, 2008-2009. Huynh TH, Johnson MW, Comer GM, Fish DN. Vitreous penetration of orally administered valacyclovir. Am J Ophthalmol 2008;145:682-6. Comer GM, Johnson MW. Coats’ Disease and Retinal Telangiectasia. In: Albert, Miller, Azar, Blodi, eds, Albert and Jakobiec’s Principles and Practice of Ophthalmology, 3rd ed. Philadelphia, PA: Elsevier, 2008 Conrad PW, Zacks DN, Johnson MW. Intravitreal bevacizumab has initial clinical benefit lasting eight weeks in eyes with neovascular age-related macular degeneration. Clin Ophthalmol 2008 [in press]. Taich A, Johnson MW. A syndrome resembling acute posterior multifocal placoid pigment epitheliopathy in older adults. Trans Am Ophthalmol Soc 2008 [in press].

Chong DY, Johnson MW. Vitelliform macular detachment associated with basal laminar drusen is unresponsive to vascular endothelial growth factor blockade. Ret Cases Brief Rep 2008 [in press].

Alon Kahana, M.D., Ph.D. Grants see grants, page 45 Awards/Honors/Leadership • Member, American Society of Ophthalmic Plastic and Reconstructive Surgery • Member, University of Michigan Comprehensive Cancer Center • Member, Scientific Advisory Committee, International Thyroid Eye Disease Society Publications Kahana A, Lucarelli MJ, Grayev AM, Van Buren JJ, Burkat CN, Gentry LR. Noninvasive dynamic magnetic resonance angiography with time-resolved imaging of contrast kineticS (TRICKS) in the evaluation of orbital vascular lesions. Arch Ophthalmol 2007;125:1635-42. Kahana A, Lucarelli MJ. Use of radiopaque intraorbital catheter in the treatment of sinoorbito-cranial mucormycosis. Arch Ophthalmol 2007;125:1714-15. Kahana A, Levin LA. Peripheral nerve tumors of the orbit. In: Albert DA, Miller JW, eds., Albert and Jakobiec’s Principles and Practice of Ophthalmology, 3rd ed. Philadelphia:WB Saunders 2007. Langenberg T, Kahana A, Wszalek JA, Halloran MC. The eye organizes neural crest cell migration. Dev Dyn 2008;237:1645-52. Kahana A, Lucarelli MJ. Corneal protective procedures: tarsorrhaphy and lacrimal occlusion. In: Brightbill FS, McDonnell PJ, McGhee CNJ, Farjo AA, Serdarevic O, eds. Corneal Surgery, 4th ed. New York:Elsevier 2008 [in press.] Kahana A, Lucarelli MJ, Burkat CN, Dortzbach RK. Diagnosis and management of orbital fractures. In: Mallajosyula S, ed., Surgical Atlas of the Orbit, Delhi, India:Jaypee Brothers 2008 [in press]. Lucarelli MJ, Ahn HB, Kulkarni A, Kahana A. Intratarsal epidermal inclusion cyst. Ophthal Plast Reconstr Surg 2008 [in press]. Kahana A, Lucarelli MJ. Adjunctive transcanthotomy lateral suborbicularis fat (SOOF) lift and orbitomalar ligament resuspension in lower lid ectropion repair. Ophthal Plast Reconstr Surg 2008 [in press]. Kahana A, Pribila JT, Nelson CC, Elner VM. Sebaceous cell carcinoma. In: Albert DM, Levin LA, eds, Ocular Disease: Mechanisms and Management. New York:Elsevier, 2008 [in press].

university of michigan kellogg eye center

Faculty honors, recognition, and publications Naheed W. Khan, Ph.D. Publications Khan NW, Wissinger B, Kohl S, Sieving PA. CNGB3 achromatopsia with progressive loss of residual cone function and impaired rodmediated function. Invest Ophthalmol Vis Sci 2008;48:3864-71. Feathers KL, Lyubarsky AL, Khan NW, Teofilo K, Swaroop A, Williams DS, Pugh EN Jr, Thompson DA. RPE65 is necessary for chromophore synthesis and outer segment morphogenesis in the cone photoreceptors of the Nrl knockout mouse. Invest Ophthalmol Vis Sci 2008;49:1126-35. Atmaca-Sonmez P, Khan NW, Heckenlively JR. Hereditary cone dystrophies. In: Albert D, Miller J, Azar D, Blodi B, eds. Principles and Practice of Ophthalmology, Philadelphia: WB Saunders 2008, Chap 178, pp. 2253-60. Oh ECT, Cheng H, Hao H, Jia L, Khan NW, Swaroop A. The rod differentiation factor NRL activates the expression of the nuclear receptor NR2E3 to suppress cone photoreceptor development. Brain Res 2008 [in press].

Hemant Khanna, Ph.D. Grants see grants, page 45 Awards/Honors/Leadership • RD2008 Young Investigator Award, Travel Fellowship, XIII International Symposium on Retinal Degenerations • Reviewer, Fight for Sight • Reviewer, Italian Telethon Foundation for Curing Genetic Diseases • Member, Proposal Review Committee, University of Michigan Undergraduate Research Opportunity Program • Member, Professional Development and Education Committee, Association for Research in Vision and Ophthalmology • Organizer, Special Interest Group Meeting: Ciliary Proteins and Retinal Degeneration: New Perspectives and Future Directions; Association for Research in Vision and Ophthalmology Publications Chakarova CF, Papaioannou MG, Khanna H, et al. Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular RPE atrophy. Am J Hum Genet 2007;81:1098-103. Cideciyan AV, Aleman TS, Jacobson SG, Khanna H, Sumaroka A, Aguirre GK, Schwartz SB, Windsor EA, He S, Chang B, Stone EM, Swaroop A. Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis. Hum Mut 2007;28:1074-83. 38

McEwen DP, Koenekoop RK, Khanna H, Jenkins PM, Lopez I, Swaroop A, Martens JR. Hypomorphic CEP290/NPHP6 mutations result in anosmia due to the selective loss of G proteins in cilia of olfactory sensory neurons. Proc Natl Acad Sci 2007;104:15917-22. He S, Parapuram SK, Hurd TW, Behnam B, Margolis B, Swaroop A, Khanna H. Retinitis pigmentosa GTPase regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked retinitis pigmentosa and associated ciliopathies. Vis Res 2008;48:366-76. Siffroi-Fernandez S, Felder-Schmittbuhl M, Khanna H, Swaroop A, Hicks D. FGF19 exhibits neuroprotective effects on adult mammalian photoreceptors in vitro. Invest Ophthalmol Vis Sci 2008;49:1696-704.

Thellea K. Leveque, M.D., M.P.H. Grants see grants, page 45 Publications Leveque TK, Yu L, Musch DC, Chervin RD, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep and Breathing 2007;11:253-7.

Erika M. Levin, M.D. Grants see grants, page 45 Awards/Honors/Leadership • Co-chair, Young Ophthalmologist Section, Michigan Society of Eye Physicians and Surgeons • Member, Membership committee, American Association for Pediatric Ophthalmology and Strabismus • Member, Bylaws and Rules Committee, American Association for Pediatric Ophthalmology and Strabismus • Invited lecturer, Department of Pediatrics, William Beaumont Hospital, Royal Oak, Michigan Publications West AL, Levin EM. Ocular injuries. In: Meredith FL, Schwab W, Taheri P, Trunkey D, eds. Trauma: Contemporary Principles and Therapy. Philadelphia:Lippincott, Williams and Wilkins, 2007. Pediatric Eye Disease Investigator Group. Primary treatment of nasolacrimal duct obstruction with probing in children younger than 4 years. Ophthalmology 2008;115:577-84.

Paul R. Lichter, M.D. Grants see grants, page 45 Awards/Honors/Leadership • Best Doctors in America

university of michigan kellogg eye center

• Lucien Howe Medal, American Ophthalmological Society • Associate Editor, American Journal of Ophthalmology • Secretary General, Academia Ophthalmologica Internationalis • Roger P. Mason Lecturer, National Medical Association Publications Jampel HD, Frick KD, Janz NK, Wren PA, Musch DC, Rimal R, Lichter PR. Depression and mood indicators in newly diagnosed glaucoma patients. Am J Ophthalmol 2007;144:238-44. Janz NK, Wren PA, Guire KE, Musch DC, Gillespie BW, Lichter PR. Fear of blindness in the Collaborative Initial Glaucoma Treatment Study: patterns and correlates over time. Ophthalmology 2007;114:2213-20. Musch DC, Gillespie BW, Niziol LM, Cashwell LF, Lichter PR. Factors associated with intraocular pressure before and during nine years of treatment in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology 2008;115:927-33. Lichter PR, Musch DC, Janz NK. The investigators’ perspective on the Collaborative Initial Glaucoma Treatment Study (CIGTS). Arch Ophthalmol 2008;126:122-24. Lichter PR. Harold F. Falls, MD (1909-2006) [obituary]. Arch Ophthalmol 2008;126:585-6. Lichter PR. Robert N. Shaffer, MD (19122007) [obituary]. Am J Ophthalmol 2008;146:143-4. Lichter PR. Debunking myths in physician– industry conflicts of interest [perspective]. Am J Ophthalmol 2008 [in press]. Lichter PR. CME, physicians and Pavlov: can we change what happens when industry rings the bell? [editorial]. Arch Ophthalmol 2008 [in press].

Michael J. Lipson, O.D. Grants see grants, page 46 Awards/Honors/Leadership • Invited lecturer, CLAO Educational Research Foundation • Invited lecturer, Illinois College of Optometry Publications Lipson MJ, Musch DC. Synergeyes vs. soft toric lenses: vision-related quality of life. Optom Vis Sci 2007;84:7:593-7. Lipson MJ. Long-term clinical outcomes of overnight corneal reshaping in children and adults. Eye and Contact Lens 2008;34:2:94-9.

Faculty honors, recognition, and publications Shahzad I. Mian, M.D. Grants see grants, page 46 Awards/Honors/Leadership • Best Doctors in America • Anthony Adamis Prize for Outstanding Research in Ophthalmology and Visual Sciences, University of Michigan, W.K. Kellogg Eye Center • Leadership Development Program, American Academy of Ophthalmology • Employee of the Year, University of Michigan, W.K. Kellogg Eye Center • Board of Directors, Midwest Eye Bank • Program Directors’ Council – Teaching and Learning Symposium Committee, American Academy of Ophthalmology • Editor, “Cornea,” Ophthalmic News and Education Network, American Academy of Ophthalmology Publications Mian SI, Shtein RM, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intralase. J Cataract Refract Surg 2007;33:1190-4. Ahmad OR, Mian SI, Sugar A. Future of keratoplasty. In: Brightbill FS, ed. Corneal Surgery, St. Louis:CV Mosby 2008 [in press]. Trizcinka A, Mian SI. Corneal biopsy. In: Dunn JP, Langer P, eds. Basic Techniques in Ophthalmic Surgery, San Francisco:American Academy of Ophthalmology 2008 [in press]. Schneider E, Mian SI. Recommended practices for femtosecond laser in refractive surgery. Am Soc Ophthalmic Reg Nurses 2008 [in press]. Malta J, Ahmad FK, Mian SI, Sugar A. Corneal inflammatory disorders. In: Trattler W, Majmudar P, Luchs J, eds: Cornea Essentials. Thorofare, New Jersey:Slack Inc. 2008 [in press].

Sayoko E. Moroi, M.D., Ph.D. Grants see grants, page 46 Awards/Honors/Leadership • Best Doctors in America • Alpha Omega Alpha, Gamma Chapter of Ohio Publications Mian SI, Shtein R, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intralase. J Cat Refract Surg 2007;33:1190-4. Rozsa F, Scott K, Pawar H, Moroi S, Richards JE. Effects of timolol on MYOC, OPTN, and WDR36 RNA levels. Arch Ophthalmol 2008;126:86-93.

Moroi SE, Richards JE. Glaucoma and genomic medicine: research results. Glaucoma Today 2008;6(1):16-24. Roberts DK, Ayyagari R, Moroi SE. Possible association between long anterior lens zonules and plateau iris configuration. J Glaucoma 2008 [in press]. Moroi SE, Heckenlively JR. Progress toward personalized medicine for age-related macular degeneration [editorial]. Ophthalmology 2008;115:925-6. Roberts DK, Lukic A, Yang Y, Moroi SEM, Wilensky JT, Wernick MN. Novel observations and potential applications using digital infrared iris imaging. Ophthalmic Surg Lasers Imaging 2008 [in press]. Trzcinka A, Soans FP, Archer SM, Moroi SE. Late-onset Haemophilus influenzae endophthalmitis in a child following Baerveldt implant. J AAPOS 2008 [in press].

David C. Musch, Ph.D., M.P.H. Grants see grants, page 46 Awards/Honors/Leadership • Editorial Board, Ophthalmology • Editorial Board, Retina • Scientific Advisory Board, Clinical and Translational Science Award, Michigan Institute for Clinical and Health Research • Consulting Editorial Board, Journal of Neuro-Ophthalmology • Chair, Special Emphasis Grant Review Panel, National Eye Institute, NIH • Methodologist, Cornea/Anterior Segment Panel, Ophthalmic Technology Assessment Committee, American Academy of Ophthalmology • Methodologist, Cornea and External Disease Preferred Practice Pattern Panel, American Academy of Ophthalmology • Reviewer, National Medical Research Council, Singapore • Member, Advisory Group, Cochrane Collaboration Eyes and Vision Group US Project • Expert group core member, Vision and Hearing Loss Expert Group, Noncommunicable Diseases Cluster, Global Burden of Diseases Study • Invited speaker, 10th Annual FDA-OCRA Educational Conference, Irvine, CA Publications Lipson MJ, Musch DC. Synergeyes vs. soft toric lenses: vision-related quality of life. Optom Vis Sci 2007;84:593-7. Mian SI, Shtein R, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intralase. J Cat Refract Surg 2007;33:1190-4.

Garcia DD, Farjo Q, Musch DC, Sugar A. The effect of prophylactic oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. Cornea 2007;26:930-4. Leveque TK, Yu L, Musch DC, Chervin RD, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep and Breathing 2007;11:253-7. Jampel HD, Frick KD, Janz NK, Wren PA, Musch DC, Rimal R, Lichter PR. Depression and mood indicators in newly diagnosed glaucoma patients. Am J Ophthalmol 2007;144:238-44. Wu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration. Clin Ophthalmol 2007;1:157-65. Janz NK, Wren PA, Guire KE, Musch DC, Gillespie BW, Lichter PR. Fear of blindness in the Collaborative Initial Glaucoma Treatment Study patterns and correlates over time. Ophthalmology 2007;114:2213-20. Musch DC, Gillespie BW, Niziol LM, Cashwell LF, Lichter PR. Factors associated with intraocular pressure before and during nine years of treatment in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology 2008;115:927-33. Lichter PR, Musch DC, Janz NK. The investigators’ perspective on the Collaborative Initial Glaucoma Treatment Study (CIGTS). Arch Ophthalmol 2008;126:122-4. Hall EF, Scott GR, Musch DC, Zacks DN. Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis following cataract surgery. Clinical Ophthalmol 2008;2:139-45. Yen KG, Elner VM, Musch DC, Nelson CC. Periocular versus general anesthesia for ocular enucleation. Ophthal Plast Reconstr Surg 2008; 24:24-8. Luttrull JK, Musch DC, Spink CA. Subthreshold diode micropulse panretinal photocoagulation for proliferative diabetic retinopathy. Eye 2008; 22:607-12. Demirci H, Johnson T, Frueh BR, Musch DC, Fullen D, Nelson CC. Management of periocular cutaneous melanoma with a staged excision technique and permanent sections: the “square procedure.” Ophthalmology 2008 [in press]. Field MG, Elner VM, Puro DG, Feuerman JM, Musch DC, Pop-Busui R, Hackel R, Heckenlively JR, Petty HR. Rapid non-invasive detection of diabetes-induced retinal metabolic stress. Arch Ophthalmol 2008 [in press].

university of michigan kellogg eye center

Faculty honors, recognition, and publications David C. Musch, cont’d

Shtein RM, Garcia DD, Musch DC, Elner VM. HSV keratitis: histopathologic predictors of corneal allograft complications. Trans Am Ophthalmol Soc 2008 [in press].

Christine C. Nelson, M.D. Grants see grants, page 46 Awards/Honors/Leadership • Best Doctors in America • Top Doctor, Hour Detroit • Guide to America’s Top Ophthalmologists • Senior Achievement Award, American Academy of Ophthalmology Publications Yen K, Elner V, Musch DC, Nelson CC. Periocular versus general anesthesia for ocular enucleation. Ophthal Plast Reconstr Surg 2008;24: 24-8.

Zhu A, Huang J-B, Clark AJ, Romero R, Petty HR. 2,5-Deoxyfructosazine, a D-glucosamine derivative, inhibits T cell Interleukin-2 production better than D-glucosamine. Carbohydr Res 2007;342:2745-9. Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462-72. Clark AJ, Petty HR. Super-quiet microfluorometry: examples of tumor cell metabolic dynamics. In: Méndez-Vilas A, Diaz J, eds. Modern Research Education: Topics on Microscopy 2007;3:403-8. Elner VM, Park S, Cornblath W, Hackel R, Petty HR. Flavoprotein autofluorescence detects early ocular dysfunction in pseudotumor cerebri. Arch Ophthalmol 2008;126:259-60.

Sisson JC, Schipper MJ, Nelson CC, Cornblath WT, Freitas JE, Frueh BR. Radioiodine therapy and Graves’ ophthalmopathy. J Nucl Med 2008;49:923-30.

Hinkovska-Galcheva V, Clark AJ, Hiraoka M, Abe A, Borofsky M, Shayman JA, Lanni F, Petty HR, Boxer LA. Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. J Lipid Res 2008;49:531-42.

Demirci H, Marentette LJ, Nelson CC. The transglabellar, subcranial approach for surgical excision of periocular second tumors in retinoblastoma. Orbit 2008 [in press].

Madsen-Bouterse S, Romero R, Xu Y, Petty HR. Quantification of O-GlcNAc protein modification in neutrophils by flow cytometry. Cytometry 2008 [in press].

Field MG, Elner VM, Puro DG, Feuerman J, Musch DC, Pop-Busui R, Hackel R, Heckenlively JR, Petty HR. Rapid, non-invasive detection of diabetes-induced ocular metabolic stress. Arch Ophthalmol 2008 [in press].

Kahana A, Pribila JT, Nelson CC, Elner VM. Sebaceous cell carcinoma. In: Albert DM, Levin LA, eds, Ocular Disease: Mechanisms and Management. New York:Elsevier, 2008 [in press]. Nelson CC, Pribila JT, Elner VM, Flint A, Frueh BR. Carcinoid tumors of the orbit: a clinicopathological review. Graefe’s Arch Clin & Exp Ophth 2008 [in press].

Howard R. Petty, Ph.D. Grants see grants, page 46 Awards/Honors/Leadership • Winner, Great Lakes Entrepreneur’s Quest, OcuSciences Publications Petty HR. Fluorescence microscopy: emerging methods and strategies to extract weak signals with applications in immunology. Micros Res Tech 2007;70:687-70.

Clark AJ, Petty HR. Observation of calcium microdomains at the uropod of living morphologically polarized human neutrophils using flashlamp-based fluorescence microscopy. Cytometry 2008 [in press].

Donald G. Puro, M.D., Ph.D. Grants see grants, page 46 Awards/Honors/Leadership • Best Doctors in America • Editorial Board Member, Microcirculation • Ad hoc member, Biology and Diseases of the Posterior Eye Study Section, Center for Scientific Review, NIH • Ad hoc member, National Eye Institute Special Emphasis Panel • Invited speaker, Physiological Society (United Kingdom) meeting concerning ion channels and the microcirculation

Huang J-B, Clark AJ, Petty HR. Preliminary report: the hexosamine biosynthesis pathway negatively regulates IL-2 production by Jurkat T cells. Cell Immunol 2007;245:1-6. 40

university of michigan kellogg eye center

Publications Puro DG. Physiology and pathobiology of the pericyte-containing retinal microvasculature: roles of ion channels and transporters. In: Tombran-Tink J, Barnstable C, eds. Ocular Transporters in Ophthalmic Diseases and Drug Delivery. Totowa, NJ:Humana Press, 127-37; 2008. Field MG, Elner VM, Puro DG, Feuerman JM, Musch DC, Pop-Busui R, Hackel R, Heckenlively JR, Petty HR. Rapid non-invasive detection of diabetes-induced retinal metabolic stress. Arch Ophthalmol 2008 [in press].

Julia E. Richards, Ph.D. Grants see grants, page 46 Awards/Honors/Leadership • Reviewer, The Glaucoma Foundation • Reviewer, Fight for Sight. • Member, Scientific Advisory Board, The Glaucoma Foundation • Member, Steering Committee, Multicenter Study to Map Novel Genes for Fuchs Corneal Endothelial Dystrophy, Case Western Reserve University • Director, Glaucoma Research Center, U-M Kellogg Eye Center • Module Director, Microarray Core Module, U-M Kellogg Eye Center • Faculty Member, Genetics Interdepart mental Concentration, U-M School of Public Health • Faculty Member, U-M Vision Science Training Program • Faculty Member, U-M Genome Sciences Training Program • Faculty Mentor, Kelloggians Trainee Group for Trainees in Vision Research • Member, Glaucoma Research Society, International Congress of Ophthalmology • Ad hoc member, Board of Scientific Counselors, National Eye Institute, NIH Publications Aldave AJ, Yellore VS, Yu F, Bourla N, Sonmez B, Salem AK, Rayner SA, Sampat KM, Krafchak CM, Richards JE. Posterior polymorphous corneal dystrophy is associated with TCF8 gene mutations and abdominal hernia. Am J Med Genet 2007;143:2549-56. Trager EH, Khanna R, Marrs A, Siden L, Branham K, Swaroop A, Richards JR. Madeline 2.0 PDE: A new program for local and web-based pedigree drawing. Bioinformatics 2007;23:1854-6. Rozsa FW, Scott K, Pawar H, Moroi S, Richards JE. Effects of timolol on MYOC. OPTN and WDR36 RNA levels. Arch Ophthalmol 2008;126:86-93.

Faculty honors, recognition, and publications Guevara-Fujita ML, Perez Grossmann R, Estrada Cuzcano A, Pawar H, Vargas E, Richards JE, Fujita R. Recurrent myocilin Asn480Lys glaucoma causative mutation arises de novo in a family of Andean descent. J Glaucoma 2008;17:67-72. Moroi SE, Richards JE. Glaucoma and genomic medicine: research results. Glaucoma Today 2008;6:16-24.

Frank W. Rozsa, Ph.D. Awards/Honors/Leadership • Invited lecturer, Geriatrics Center Research Symposium, University of Michigan Publications Rozsa FW, Scott K, Pawar H, Moroi S, Richards JE. Effects of Timolol on MYOC, OPTN, and WDR36 RNA levels. Arch Ophthalmol 2008;126:86-93.

Stephen J. Saxe, M.D. Awards/Honors/Leadership • Best Doctors in America Outreach • Special guest lecturer, physician, and mentor: Guatemala City, World Eye Mission

Roni M. Shtein, M.D. Grants see grants, page 46 Publications Mian SI, Shtein RM, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intralase. J Cataract Refract Surg 2007;33:1190-4. Sugar A, Mintz R. Koch-Weeks bacillus. In: Roy FH, Fraunfelder F, eds. Current Ocular Therapy, 6th ed., Philadelphia: WB Saunders, 2007.

• Invited speaker and visiting professor, National Taiwan University Hospital (Taipei, Taiwan) • Invited speaker, World Ophthalmology Congress

Stein JD, McDonnell PJ, Lee PP. Penetrating keratoplasty and glaucoma. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, 3rd ed. Philadelphia: Saunders 2008 [in press].

Publications Malta JB, Soong HK. Diamond drill superficial keratectomy in the treatment of visuallysignificant anterior corneal lesions. Arquivos Brasileiros de Oftalmo 2008 [in press].

Stein JD, Lee PP. Age and racial variation in the prevalence of open-angle glaucoma in the United States. In: Tombran-Tink J, Barnstalde CJ, Shields MB, eds, Mechanisms of the Glaucomas 2008 [in press].

Malta JB, Banitt M, Soong HK. Free-floating cyst in anterior chamber after cataract surgery. Br J Ophthalmol 2008 [in press].

Alan Sugar, M.D.

Romero I, Paiato TP, Silva CB, Malta JB, Mimica LMG, Soong HK, Hida RY. Different application volumes of ethyl-cyanoacrylate tissue adhesive can change its antibacterial effects against ocular pathogens in vitro. Curr Eye Res 2008 [in press]. Soong HK, Malta JB, Mian SI, Juhasz T. Femtosecond laser-assisted lamellar keratoplasty. Arquivos Brasileiros Oftalmol 2008 [in press].

Awards/Honors/Leadership • Invited lecturer, International Ocular Inflammation Society, Paris, France • Distinguished Alumnus Lecturer, Ethical and Regulatory Basis of Research in Ophthalmology, Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO

Banitt MR, Malta JB, Shtein RM, Soong HK. Delayed-onset isolated central Descemet’s membrane blister detachment following phacoemulsification. J Cat Refract Surg 2008 [in press].

Publications Garcia DD, Farjo Q, Musch DC, Sugar A. The effect of prophylactic oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. Cornea 2007;26:930-4.

Joshua D. Stein, M.D. Awards/Honors/Leadership • Editorial Board, Evidence-Based Ophthalmology • Judge, Ophthalmology Times Resident Writer’s Award Publications Stein JD, Ruiz D, Belsky S, et al. Longitudinal rates of postoperative adverse outcomes following glaucoma surgery among Medicare beneficiaries. Ophthalmology 2008; 115:1109-16.

Shtein RM, Garcia DD, Musch DC, Elner VM. HSV keratitis: histopathologic predictors of corneal allograft complications. Trans Am Ophthalmol Soc 2008 [in press].

Stein JD, Newman-Casey P. Glaucoma associated with corneal disorders. In: Tasman W, Jaeger EA, eds. Duane’s Clinical Ophthalmology, Foundations Vol. III, chap 54f, Philadelphia, PA: Lippincott Williams & Wilkins 2008.

Banitt MR, Malta JB, Shtein RM, Soong HK. Delayed-onset central Descemet’s membrane detachment following phacoemulsification. J Cataract Refract Surg 2008 [in press].

Stein JD, Herndon LW, Bond B, Challa P. Exposed Ex-PRESS tube shunts: case series and technique for tube shunt removal Glaucoma 2008;16:704-6.

H. Kaz Soong, M.D. Grants see grants, page 46 Awards/Honors/Leadership • Honorary Diploma, Member of Bulgarian Union of Ophthalmology • Invited speaker, 61st Annual Congress of Japanese Clinical Ophthalmology (Kyoto, Japan)

Grants see grants, page 47

Stein JD, Ayyagari P, Sloan FA, Lee PP. Rates of glaucoma medication utilization among persons with primary open-angle glaucoma, 1992 to 2002. Ophthalmology 2008 [Epub ahead of print]. Stein JD, Lee PP. Screening for glaucoma. In: Yanoff M, Duker JS, eds. Ophthalmology, 3rd ed. St. Louis:Mosby 2008 [in press].

Patel SV, Sugar A. Dermatophytosis. In: Roy FH, Fraunfelder F, eds. Current Ocular Therapy, 6th ed. Philadelphia:WB Saunders, 2007. Sugar A, Mintz R. Koch-Weeks bacillus. In: Roy FH, Fraunfelder F, eds. Current Ocular Therapy, 6th ed. Philadelphia:WB Saunders, 2007. Cornea Donor Study Investigator Group (Sugar A, writing committee). The effect of donor age on corneal transplantation. Results of the Cornea Donor Study. Ophthalmology 2008;115:620-6. Cornea Donor Study Investigator Group (Sugar A, writing committee). Donor age and corneal endothelial cell loss 5 years after successful corneal transplantation: Specular Microscopy Ancillary Study results. Ophthalmology 2008;115:627-32. Schallhorn SC, Farjo AA, Huang D, Boxer Wachler BS, Trattler WB, Tanzer DJ, Majmudar PA, Sugar A. Wavefront-guided LASIK for the correction of primary myopia and astigmatism. A report by the American Academy of Ophthalmology. Ophthalmology 2008;115:1294-61. Malta J, Ahmad FK, Mian SI, Sugar A. Corneal inflammatory disorders. In: Trattler W, Majmudar P, Luchs J, eds: Cornea Essentials. Thorofare, New Jersey:Slack Inc. 2008 [in press].

university of michigan kellogg eye center

Faculty honors, recognition, and publications Alan Sugar, cont’d

Ahmad OR, Mian SI, Sugar A. Future of keratoplasty. In: Brightbill FS, ed. Corneal Surgery. St. Louis:CV Mosby 2008 [in press].

Anand Swaroop, Ph.D. Grants see grants, page 47 Awards/Honors/Leadership • Editorial Board, Investigative Ophthalmology & Visual Science • Editorial Review Board, Molecular Vision • Reviewer, The Wellcome Trust, London,UK • Reviewer, Agence Nationale de la Recherche – Biotechnology and Biological Sciences Research Council • 29th Annual Distinguished Faculty Lecturership Award, University of Michigan Medical School • Invited lecturer, Bhubaneswar L V Prasad Eye Institute, Bhubaneswar, India • Invited lecturer, Symposium, “Trends in Human Genetics,” Toshali Sands, Puri, India • Invited lecturer, Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH • Invited plenary talk, annual retreat, Comparative Medicine and Integrative Biology Graduate Program, Michigan State University, East Lansing, MI • Invited lecturer, Save Sight Sunday Symposium, The Foundation Fighting Blindness North California Chapter • Invited lecturer, Department of Genetics, Faculty of Biology, University of Barcelona • Guest lecturer, Hospitales Universitarios Virgin del Rocio, Seville, Spain Publications Raven M, Oh E, Swaroop A, Reese B. Afferent control of horizontal cell morphology revealed by genetic re-specification of rods and cones. J Neurosci 2007;27:3540-7. Trager EH, Khanna R, Marrs A, Siden L, Branham K, Swaroop A, Richards JR. Madeline 2.0 PDE: A new program for local and web-based pedigree drawing. Bioinformatics 2007;23:1854-6. Cideciyan AV, Aleman TS, Jacobson SG, Khanna H, Sumaroka A, Aguirre GK, Schwartz SB, Windsor EAM, He S, Chang B, Stone EM, Swaroop A. Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis. Hum Mutation 2007;28:1074-83. Duncan JL, Zhang Y, Gandhi J, Nakanishi C, Othman M, Branham KEH, Swaroop A, Roorda A. High-resolution imaging with adaptive optics in patients with inherited retinal degeneration. Invest Ophthalmol Vis Sci 2007;48:3283-91. 42

Swain P, Kumar S, Patel D, Richong S, Oberoi P, Ghosh M, Swaroop A. Mutations associated with retinopathies alter mitogenactivated protein kinase-induced phosphorylation of neural retina leucine-zipper. Mol Vis 2007;13:1114-20. Swaroop A, Branham KEH, Chen W, Abecasis G. Genetic susceptibility to agerelated macular degeneration: a paradigm for dissecting complex disease traits [invited review]. Hum Mol Genet 2007;16 Spec No 2:R174-82. Kanda A, Chen W, Othman M, Branham KEH, Brooks M, Khanna R, He S, Lyons R, Abecasis GR, Swaroop A. A variant of mitochondrial protein LOC387715, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci USA 2007;104:16227-32. McEwen DP, Koenekoop RK, Khanna H, Jenkins PM, Lopez I, Swaroop A, Martens JR. Hypomorphic CEP290/NPHP6 mutations result in anosmia due to the loss of G-proteins in cilia of olfactory sensory neurons. Proc Natl Acad Sci USA 2007;104:15917-22. Iannaccone A, Othman MI, Cantrell AD, Jennings BJ, Branham K, Swaroop A. Retinal phenotype of an X-linked pseudo-Usher syndrome in association with the G173R mutation in the RPGR gene. Adv Exp Med Biol 2008;613:221-7. He S, Parapuram SK, Hurd TW, Behnam B, Margolis B, Swaroop A, Khanna H. Retinitis pigmentosa GTPase regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked retinitis pigmentosa and associated ciliopathies. Vision Res 2008;48:366-76. Oh E, Cheng H, Hao H, Jia L, Khan NW, Swaroop A. Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors. Brain Res 2008 [in press]. Walia S, Fishman GA, Swaroop A, Branham KEH, Lindeman M, Othman M, Weleber RG. Discordant phenotypes in fraternal twins having identical mutation in exon ORF15 of the RPGR gene. Arch Ophthalmol 2008;126:37984. Feathers K, Lyubarsky A, Khan N, Teofilo K, Swaroop A, Williams D, Pugh E, Thompson D. Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments. Invest Ophthalmol Vis Sci 2008;49:1126-35. Siffroi-Fernandez S, Felder-Schmittbuhl M, Khanna H, Swaroop A, Hicks D. FGF19 exhibits neuroprotective effects on adult mammalian photoreceptors in vitro. Invest Ophthalmol Vis Sci 2008;49:1694-1704.

university of michigan kellogg eye center

Kanda A, Abecasis G, Swaroop A. Inflammation in the pathogenesis of age-related macular degeneration. [editorial]. Br J Ophthalmol 2008;92:448-50.

Debra A. Thompson, Ph.D. Grants see grants, page 47 Publications Feathers KL, Lyubarsky AL, Khan NW, Teofilo K, Swaroop A, Williams DS, Pugh EN Jr, Thompson DA. Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments. Invest Ophthalmol Vis Sci 2008;49:1126-35.

Susan S. Thoms, M.D. Awards/Honors/Leadership • Best Doctors in America Outreach •Training students for global outreach; a medical student worked in rural Mongolia and an undergraduate student worked in Ghana through Fight for Sight.

Jonathan D. Trobe, M.D. Awards/Honors/Leadership • Best Doctors in America • Visiting Professor, Longwood Program in Neurology, Harvard Medical School • Visiting Professor, Department of Neurology, Massachusetts General Hospital, Harvard Medical School • Henry Van Dyke Lecturer, Department of Ophthalmology, Louisiana State University • Keynote Speaker, Asian Neuro Ophthalmology Society, Taipei • Keynote Speaker, German Ophthalmology Congress, Berlin • Visiting Lecturer, Birmingham Eye Hospital, Birmingham, England • Editor-in-Chief, Journal of Neuro Ophthalmology Publications Chong DY, Comer GM, Trobe JD. Optic disc edema, cystoid macular edema, and elevated vascular endothelial growth factor in a patient with POEMS syndrome. J NeuroOphthalmol 2007;27:180-3. Margolin E, Gujar SK, Trobe JD. Isolated cortical visual loss with subtle brain MRI abnormalities in a case of hypoxic-ischemic encephalopathy. J Neuro-Ophthalmol 2007;27:292-6. Margolin E, Flint A, Trobe JD. High-titer collapsing response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and vitritis as the only clinical manifestations in a patient with small cell lung carcinoma. J Neuro-Ophthalmol 2008;28:17-22.

Faculty honors, recognition, and publications Hassan KA, Kalemkerian GP, Trobe JD. Long-term survival in paraneoplastic opsoclonus-myoclonus syndrome associated with small cell lung cancer. J Neuro-Ophthalmol 2008;28:27-30. Pribila JT, Ronan SM, Trobe JD. Multiple intracranial meningiomas causing papilledema and visual loss in a patient with nevoid basal cell carcinoma syndrome. J Neuro-Ophthalmol 2008;28:41-6. Trobe JD. Rapid Diagnosis in Neuro-Ophthalmology. Edinburgh, Scotland:Elsevier Books, 2008.

Andrew K. Vine, M.D. Grants see grants, page 47 Awards/Honors/Leadership • Best Doctors in America Publications The PKC-DMES Study Group. Effect of Ruboxistaurin in patients with diabetic macular edema. Arch Ophthalmol 2007;125: 318-24. Demirci H, Vine AK, Elner VM. Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma. Ophthalmic Surg Lasers Imaging 2008;39:57-9.

Jennifer S. Weizer, M.D. Awards/Honors/Leadership • Director, Fellowship program, University of Michigan W.K. Kellogg Eye Center • Invited lecturer, American Glaucoma Society, Washington, DC Publications Weizer JS, Asrani S, Stinnett SS, Herndon LW. The clinical utility of dynamic contour tonometry and ocular pulse amplitude. J Glaucoma 2007;16:700-3. Weizer JS, Lee PP. Primary open-angle glaucoma. Atlas of Glaucoma, 2nd ed. Informa Healthcare, 2007 [in press] Weizer JS. Acute angle-closure glaucoma. Up-to-Date 2008 [in press].

Rebecca A. Wu, M.D. Publications Wu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration. Clin Ophthalmol 2007;1:157-65.

Dongli Yang, M.D., Ph.D. Publications Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462-72. Yang D, Swaminathan A, Zhang X, Hughes BA. Expression of Kir7.1 and a novel Kir7.1 splice variant in native human retinal pigment epithelium. Exp Eye Res 2008;86:81-91. Yang D, Zhang X, Hughes BA. Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium. Exp Eye Res 2008 [in press].

Chong DY, Boehlke CS, Zheng QD, Zhang L, Han Y, Zacks DN. Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 2008;49:3193-3200. Grabe H, Zacks DN. Seat belt retinopathy: a case of Purtscher-like retinopathy following a motor vehicle accident. Retinal Cases and Brief Reports 2008 [in press]. Conrad PW, Zacks DN, Johnson MW. Intravitreal bevacizumab has initial clinical benefit lasting eight weeks in eyes with neovascular age-related macular degeneration. Clinical Ophthalmol 2008 [in press].

Elner SG, Elner VM, Field MG, Park S, Yang D, Heckenlively JR, Petty HR. Retinal flavoprotein autofluorescence as a measure of retinal health. Trans Am Ophthalmol Soc 2008 [in press].

David N. Zacks, M.D., Ph.D. Grants see grants, page 47 Awards/Honors/Leadership • Section Moderator: Basic Science Section, 31st Macula Society annual meeting • Co-Director, 80th Annual Spring Conference, University of Michigan Department of Ophthalmology and Visual Sciences • Honorary Co-Chair, Foundation Fighting Blindness Eastern Michigan Vision-Walk • Keynote speaker, VISIONS 2008 • Guest faculty, 3rd Annual Heed Ophthalmologic Foundation Faculty–Resident Retreat • Section Moderator: Retinal Detachment– A Symposium in Honor of Charles L. Schepens, MD, 40th Annual Retina Society Meeting Publications Zacks DN, Boehlke C, Richards AL, Zheng QD. Photoreceptor neuroprotection: the role of the FAS signaling pathway. Arch Ophthalmol 2007;125:1389-95. Leveque TK, Yu L, Musch DC, Chervin RC, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep and Breathing 2007;11:253-7. Hall EF, Scott GR, Musch DC, Zacks DN. Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis following cataract surgery. Clinical Ophthalmol 2008;2:139-45.

university of michigan kellogg eye center

grants

Faculty Name

Source

R. Ayyagari, Ph.D. NIH R01-EY13198-06 R01-EY13198-06S1 FFB RPB

Project Title Macular Degeneration: Genetics of 4 Distinct Phenotypes Center for the Study of Retinal Degenerative Diseases International Research Scholar Award

T. Bergstrom, M.D. NIH/Clinical Trial U10-EY10439-15 Ocular Hypertension Treatment Study (OHTS) Coordinating Center: Washington University M. Del Monte, M.D. NIH/Clinical Trial U10-EY11751 Pediatric Eye Disease Investigator Group Multiple Projects, Coordinating Center: Jaeb Pfizer Ophthalmics Research Phase I Open Label Study of Latanoprost in Pediatric and Adult Glaucoma Patients J. Demb, Ph.D. NIH R01-EY14454-04 Functional Circuitry of Visual Adaptation RPB Career Development Award Sloan Foundation Sloan Research Fellowship S. Elner, M.D. NIH/Clinical Trial U10-EY14660 Multicenter Uveitis Steroid Treatment (MUST) Trial Coordinating Center: Johns Hopkins University V. Elner, M.D., Ph.D. NIH R01-EY09441-13 RPB U-M Medical School Michigan Universities Commercialization Initiative

RPE-MÎŚ Binding: Ca++ & O2- Dependent AMD Responses Senior Scientific Investigator Award Translational Research Initiatives Program Grant Prototype Development ETCF Grant

P. Gage, Ph.D. NIH R01-EY14126-05 Pitx 2: Molecular Mechanisms in Eye Development and Disease D. Green, Ph.D. NIH R01-EY10084-06 Clinical and Molecular Analysis of Oregon Eye Disease Subcontract with De-Ann Pillers, M.D., Ph.D., Oregon Health and Science University J. Heckenlively, M.D. NIH R01-EY07758-20 Mouse Models of Human Hereditary Eye Diseases NIH R01-EY16862-03 Genetic Variations in Age-Related Macular Degenerations FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Assessment of Therapies FFB Resource Facility for X-linked Retinitis Pigmentosa and Age-Related Macular Degeneration Neurotech USA Phase II/III Study of Encapsulated Human Cell Implants Releasing CNTF for Participants with Retinitis Pigmentosa Sramek Foundation Interactive and Integrated Genetic Databases for the Study of Age-Related Macular Degeneration

university of michigan kellogg eye center

grants

Faculty Name

Source

Project Title

P. Hitchcock, Ph.D. NIH R01-EY07060-19 Neuronal Development, Injury and Regeneration in Retina NIH R01-EY11115-11 Molecular Mechanisms of Retina-Specific Gene Expression NIH T32-EY17878-06 Early Stage Training in the Neurosciences FFB – Canada Identification and Function of Molecular Cues for Photoreceptor Regeneration in the Vertebrate Retina RPB Senior Scientific Investigator Award B. Hughes, Ph.D. NIH P30-EY07003-22 Core Center for Vision Research (four core modules) NIH R01-EY08850-17 Ion Conductances in the Retinal Pigment Epithelium RPB Lew R. Wasserman Award M. Johnson, M.D. NIH/Clinical Trial N01-EY12113 Preservative-Free Triamcinolone Acetonide as an Adjunct to Photodynamic Therapy for Age-Related Macular Degeneration, Coordinating Center: Emmes NIH/Clinical Trial U10-EY14351 Standard Care Versus Corticosteroid for Retinal Vein Occlusion (SCORE) Study, Coordinating Center: University of Wisconsin Genentech, Inc./Clinical Trial Ranibizumab in Naïve and Previously Treated Subjects with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration GlaxoSmithKline/Clinical Trial Study to Investigate Pharmacodynamics, Safety, and Systemic Pharmacokinetics of Pazopanib Eye Drops Regeneron Pharmaceutical/Clinical Trial Phase III Study of Efficacy, Safety, and Tolerability of Repeated Doses of Intravitreal VEGF Trap in Subjects with Neovascular AMD A. Kahana, M.D., Ph.D. NIH K08-EY018689-01 Zebrafish Model for Studying Orbital Development and Disease H. Khanna, Ph.D. NIH R01-EY07961-18 X-Linked Retinitis Pigmentosa FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Transplantation of Photoreceptor Precursors Midwest Eye-Banks Elucidation of Ciliary Dysfunction in CEP290/NPHP6 T. Leveque, M.D. NIH M01-RR00042 Prevalence of Obstructive Sleep Apnea in Patients with Central Serous Chorioretinopathy – funded by a Clinical and Translational Science Award E. Levin, M.D. NIH/Clinical Trial U10-EY11751 Pediatric Eye Disease Investigator Group Multiple Projects, Coordinating Center: Jaeb P. Lichter, M.D. RPB Unrestricted Grant VisionCare Ophthalmic Technologies/ VisionCare Ophthalmic Technologies Implantable Clinical Trial Miniature Telescope for Central Vision Impairment Associated with Age-Related Macular Degeneration and Other Maculopathies

university of michigan kellogg eye center

grants

Faculty Name

Source

Project Title

M. Lipson, O.D. EyeVis L.L.C. Stabilizing Myopia by Accelerated Reshaping Technique S. Mian, M.D. NIH R01-EY14163-01 Femtosecond Laser Posterior Lamellar Keratoplasty Subcontract with Tibor Juhasz, Ph.D., University of California - Irvine Fight for Sight and MICHR Femtosecond Laser-Assisted Keratoplasty S. Moroi, M.D., Ph.D. Pfizer/Clinical Trial Xalacom Given in the Evening, Xalatan in the Evening, and Timolol S in the Morning for Open-angle Glaucoma or Ocular Hypertension U-M Medical School Improving Trabeculectomy Outcome with Human Amniotic Membrane D. Musch, Ph.D., M.P.H. Midwest Eye-Banks

Long-Term Follow-up of Keratoconus Recipients

C. Nelson, M.D.

Genetics of Anophthalmia in a 3-Generation Pedigree Medical Student Fellowship

Midwest Eye-Banks Midwest Eye-Banks

H. Petty, Ph.D. NIH N01-HD-2-3342 Services in Support of the Perinatology Research Branch Subcontract with Wayne State University NIH R01-CA74120-10 Signaling Dynamics of Leukocyte-Tumor Cell Interactions NIH R01-AI60983-02 Lipid Raft Microdomains in Neutrophil Function Subcontract, Robert Sitrin, M.D., U-M Medical School Arthritis Foundation Novel Anti-Inflammatory Peptides Based upon FcRIIA Midwest Eye -Banks Time-Gated Single Molecule Fluorescence Imaging U-M Medical School Translational Research Initiatives Program Grant Wilson Foundation Signal Waves in Tumor Cell Killing: A Systems Biology Approach in Oncology D. Puro, M.D., Ph.D. NIH R01-EY12507-09 Physiology of Retinal Pericytes NIH T32-EY013934 Vision Research Training Program RPB Senior Scientific Investigator Award J. Richards, Ph.D. NIH R01-EY11671-08 Molecular Genetics of Glaucoma and Related Disorders AHAF Genetic Risk Factors and Glaucoma Outcomes Fight for Sight Sequence Variants in CLCN3 and the Associated Risk of Glaucoma â&#x20AC;&#x201D; Student Fellowship R. Shtein, M.D.

NIH K23-EY017885-01 MICHR

Neovascularization Patterns in Corneal Graft Rejection Pathogenesis of Idiopathic Dry Eye

H. Kaz Soong, M.D. NIH R01-EY014456 Femtosecond Laser Enhanced Aqueous Outflow Facility Subcontract with Tibor Juhasz, Ph.D., University of California - Irvine

university of michigan kellogg eye center

grants

Faculty Name

Source

Project Title

A. Sugar, M.D. NIH/Clinical Trial U10-EY12358 Cornea Donor Study, Coordinating Center: Jaeb NIH/Clinical Trial R01-EY016482 A Multi-Center Study to Map Genes for Fuchs Dystrophy Coordinating Center: Case Western Reserve University Lux Biosciences, Inc. A Randomized Dose-Ranging Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure following Penetrating Keratoplasty A. Swaroop, Ph.D. NIH P50-DK39255-19 Function of Ciliary Protein RPGR in Renal Epithelial Cells: Possible Implications for Renal-Retinal Disease Subcontract, Roger Wiggins, M.D., U-M Medical School NSF DBI 0543272 Integrated Biological Sequence Data Management Subcontract, Alfred Hero, Ph.D., University of Michigan Fight for Sight Screen for Human Mutations in RD11, the Gene Responsible for the rd11 Mouse Retinopathy — Student Fellowship Fight for Sight Novel Leucine-Rich Proteins— Student Fellowship Thompson Foundation Macular Degeneration Research Project D. Thompson, Ph.D. FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Small Molecular Interventions A. Vine, M.D. LMRI/Clinical Trial A Natural History Study of Macular Telangiectasia — The MacTel Study D. Zacks, M.D., Ph.D. NIH K08-EY14705-05 Apoptosis in Retinal Detachments FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Transplantation of Photoreceptor Precursors IRRF Control of Photoreceptor Apoptosis Midwest Eye-Banks Intravitreal Linezolid in Rabbits: an Electrophysiologic and Histopathologic Analysis RPB Career Development Award Source Abbreviations AHAF – American Health Assistance Foundation

MICHR – Michigan Institute for Clinical and Health Research

FFB – Foundation Fighting Blindness NIH – National Institutes of Health IRRF – International Retinal Research Foundation NSF – National Science Foundation LMRI – Lowy Medical Research Institute

RPB – Research to Prevent Blindness

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Faculty of the Department of Ophthalmology and Visual Sciences 2007â&#x20AC;&#x201C; 2008

our mission To solve the puzzles of blinding eye disease, to improve the quality of life for our patients, and to teach the next generation of vision scientists and clinicians.

Executive Officers of the University of Michigan Health System

For additional copies of this report,

Robert P. Kelch, M.D.

please contact us at:

Executive Vice President for Medical Affairs Douglas L. Strong, M.B.A.

University of Michigan

Director and CEO, University of Michigan Hospitals and Health Centers

Department of Ophthalmology

James O. Woolliscroft, M.D.

and Visual Sciences

Dean, University of Michigan Medical School

W.K. Kellogg Eye Center

The Regents of the University of Michigan

1000 Wall Street Ann Arbor, Michigan 48105

Julia Donovan Darlow, Ann Arbor; Laurence B. Deitch, Bingham Farms; Olivia P. Maynard, Goodrich; Rebecca McGowan, Ann Arbor;

734.647.5586

Andrea Fischer Newman, Ann Arbor; Andrew C. Richner, Grosse Pointe Park;

www.kellogg.umich.edu

S. Martin Taylor, Grosse Pointe Farms; Katherine E. White, Ann Arbor; Mary Sue Coleman, Ph.D., ex officio

Editors: Betsy Nisbet, Randy Wallach Writers and Editorial Assistants: Aimee Bergquist, Lisa Burkhart, MargaretAnn Cross Design: David Murrel Photographers: Scott Galvin, Lin Jones, Scott Soderberg, Martin Vloet: U-M Photo Services; Robert Prusak: U-M Department of Ophthalmology and Visual Sciences Portrait of William Carls (p. 24) painted by Robert Maniscalco. Photograph courtesy of Childrenâ&#x20AC;&#x2122;s Hospital of Michigan.

We are pleased to be ranked among the top hospitals in the nation for Ophthalmology in the 2008 U.S.News & World Report survey.