2007 Annual Report - U-M Kellogg Eye Center

university of michigan kellogg eye center 2007 annual Report

Table of Contents This report covers the period July 1, 2006 through June 30, 2007.

University of Michigan Department of Ophthalmology and Visual Sciences

RESEARCH

5

Will a new therapeutic implant save — or even restore — vision for people with RP? A clinical trial is under way to test an innovative treatment.

EDUCATION

11

Kellogg’s residency program trains the brightest and best, providing support and opportunities for research.

ALUMNI

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Alumni of the Department make a difference in academic centers, private practice, and research institutions around the world.

PATIENT CARE

17

Part advocate, part teacher, Kellogg’s genetic counselors help patients understand the intricacies of inherited eye disease.

OUTREACH

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In Guatemala, a Kellogg physician teaches, performs surgery, and successfully treats a family with a rare hereditary syndrome.

GIVING

23

Generous supporters of the Department help make the Eye Center expansion a reality.

Two Kellogg faculty members fund professorships.

PUBLICATIONS & GRANTS Faculty of the Department publish widely and attract critical research funding.

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Dear Friends, This is the Department of Ophthalmology’s 135th anniversary, a remarkable event in any year, but especially significant this year because we have also celebrated groundbreaking for a greatly expanded eye center. It would have been difficult for our founders to imagine the extent to which the Department and the entire medical center have grown since those early years.

We have trained 435 residents since 1872. They,

along with clinical and research fellows, have had a substantial impact on the fields of ophthalmology and visual sciences. Today you can find our alumni in nearly every state of the nation and in many countries around the world.

We can offer our patients specialized treatment that was unimaginable 135 or

even 35 years ago, and not necessarily available in all medical centers today. For example, one Kellogg physician performed successful surgery on a 5-month-old baby with glaucoma. Another traveled to Central America and performed surgery on a mother and son whose vision was impaired by a rare genetic syndrome. Both stories are in this report.

Vision research has also followed a remarkable trajectory. Who could imagine

in 1872 that today we would be testing an implant that could very well turn out to be the first viable treatment for a degenerative eye disease? Or that our own faculty would invent an imaging device capable of detecting eye disease before any visible signs occur?

We have also developed some steadfast friendships over the years. It is with

deep gratitude that I wish to thank the many supporters who have made our growth possible, particularly this year as our state-of-the-art eye care facility takes shape.

Many of you joined us at our groundbreaking ceremony last fall. In February construction began in earnest and now the steel beam structure is nearly in place for our new 8-story, 230,000-square-foot building that will house all of our clinics, operating rooms, and a portion of our research laboratories.

So much “history” has happened just this year, as well as over the past 135

years. Many individuals have contributed to our success, from faculty to alumni to donors. It’s a good year to say thanks to all of you.

Paul R. Lichter, M.D. F. Bruce Fralick Professor and Chair University of Michigan Department of Ophthalmology and Visual Sciences Director, W.K. Kellogg Eye Center

135 years of excellence

1870s

1893

Leaders in Ophthalmology since 1872

1890s

The Department of Ophthalmology was established in 1872, just 22 years after the U-M Medical School was founded. For 135 years, the Department’s faculty have made significant and lasting contributions to the field of ophthalmology. Here are a few measures of the faculty’s impact on patient care, education, and vision research.

While our research program star ted in the 1930s, it was not until later that more complete records were kept.

GRANT AWARDS TO THE KELLOGG EYE CENTER

university of michigan kellogg eye center

PATIENT VISITS TO U-M OPHTHALMOLOGISTS

in ophthalmology

1920s

1983

2010

133 FELLOWS HAVE RECEIVED SUBSPECIALT Y TRAINING SINCE 1965

CHAIRS OF THE DEPARTMENT HAVE TRAINED 435 RESIDENTS SINCE 1879

Number of residents

1 CLINICAL RESEARCH

GEORGE E. FROTHINGHAM, M.D. 1872 - 1889

26 CORNEA

FLEMMING CARROW, M.D. 1889 - 1904

1 COMPREHENSIVE OPHTHALMOLOGY

WALTER R. PARKER, M.D. 1904 - 1932

28 GL AUCOMA

F. BRUCE FRALICK, M.D. 1933 - 1968

18 NEURO-OPHTHALMOLOGY

JOHN W. HENDERSON , M.D., PH.D. 1968 - 1978

25 PEDIATRIC OPHTHALMOLOGY

PAUL R. LICHTER, M.D. 1978 - PRESENT

17 EYE PL ASTICS 17 RETINA

2007 annual Report

“In light of the preliminary work on CNTF, there are high expectations for this new therapeutic technology. This is the first non-specific therapy to emerge with promising experimental results.”

—John R. Heckenlively, M.D.

university of michigan kellogg eye center

Clinical Testing to Start on Treatment for RP

Evaluating RP therapy with hope and caution People with retinitis pigmentosa have watched and

waited for news of any treatment that might stop the progression of the disease or even allow them to recover lost vision. Now there is some reason to hope that a sustainedrelease implant being evaluated at the U-M Kellogg Eye Center and 13 other centers across the nation could deliver the long-awaited therapy.

Participants whose condition meets specific criteria will have surgery to receive an implant that releases a naturally occurring protein known to retard retinal degeneration.

Pamela Titus, C.O.T., is Clinical Coordinator for the treatment trial.

Today patients with retinitis pigmentosa (RP) have very few treatment options. Antioxidant vitamins may help, but they do not cure. There are no known effective “In light of the preliminary work on CNTF, there are treatments for these degenerative eye diseases that affect high expectations for this new therapeutic technology,” 100,000 Americans and, over time, can lead to blindness. says Dr. Heckenlively. “This is the first non-specific therapy

John R. Heckenlively, M.D., an internationally known to emerge with promising experimental results.” He adds expert on inherited retinal disease, will lead the study for that RP is difficult to treat, in part, because there are so the U-M Kellogg Eye Center. He is cautiously optimistic many genetic forms. “Rather than targeting a particular about the prospects for the new treatment because earlier type of RP,” says Dr. Heckenlively, “this new therapy research has demonstrated that the focuses on the endpoint of all RP types: protein, ciliary neurotrophic factor “I’m hoping that if this vision loss due to degeneration of (CNTF), has the ability to slow the photoreceptors.” study is successful, the degeneration of photoreceptors, the In 2005, a Phase I Clinical Trial light-sensing cells essential for sight. concluded that the CNTF implant treatment will become Dr. Heckenlively, Paul R. Lichter Profesexhibited a safe profile for humans. routine for people with sor of Ophthalmic Genetics, explains Currently, two Phase II/III clinical trials that after a promising start in the early are evaluating two different doses of RP and other types of 1990s, the research on CNTF stalled for CNTF: a high dose or a low dose in one eye diseases.” lack of a practical method to deliver the eye, as well as a sham surgery in the

— Vicki parker therapeutic protein to the eye. With the other eye so participants will not know development of encapsulated cell technology by Neurowhich eye has been treated with CNTF. tech USA, Inc., the delivery problem appears to have

Vicki Parker, whose mother and grandmother both been solved. had RP, hopes to participate in the trial. “With my family

The symptoms and severity of RP can vary, but the dishistory, I’m lucky. My mother and grandmother both had ease often begins with the loss of peripheral or side vision some vision in their final years,” she says. “Naturally, I’m and difficulty seeing at night. As the disease progresses, an always interested in the latest research. I’m hoping that if individual will have a narrower range of vision, resulting this study is successful, the treatment will become routine in tunnel vision. The remaining vision may or may not be for people with RP and other types of eye diseases.” clear and sharp.

2007 annual Report

Building a Better Ophthalmoscope

While the device has the potential for detecting diseases

Metabolic imaging detects early eye disease

such as glaucoma and macular degeneration, the inventors believe that its initial impact will be on those at risk for diabetes. Often, changes in the retina are the first signals that a person may be entering a pre-diabetic state. “About 50 million people have pre-diabetes,” says Dr. Elner. “When these individuals receive early treatment, it has been shown that 30 percent will not go on to develop the disease.”

Dr. Elner believes that the instrument will play an important role in controlling a disease that affects millions of people every year and is the leading cause of blindness and other

Two Kellogg faculty members have developed an early warning device for eye disease. After a

year of development and testing, they have collected data showing that the highly sensitive optical instrument can detect signs of disease before symptoms appear.

Now Howard R. Petty, Ph.D., and Victor M. Elner, M.D., Ph.D., have formed a company, OcuSciences, Inc., to develop the instrument and take it to a wider market. They have good reason to believe they will be successful. The business partners received the SPARK Entrepreneur Award, first place, from the Ann Arbor-based economic development group.

Victor M. Elner, M.D., Ph.D., and Howard R. Petty, Ph.D., have invented an instrument that captures cell activity within the eye.

debilitating complications in the developed world.

The new high-tech ophthalmoscope measures the metabolism of both healthy and diseased tissue, a technique that can reveal the earliest stages of eye disease in fragile retinal tissue. The device is the result of Dr. Petty’s pioneering research on both metabolism and imaging. He is a noted biophysicist and holds a number of patents for previous inventions. Dr. Elner is an ophthalmologist and a pathologist, perhaps one of a dozen or so in the country who is an authority in these two scientific disciplines. His research dealing with pathologic metabolic alterations in retinal cells—how they behave under the stress of disease— meshed with Dr. Petty’s imaging research and together they developed this innovative instrument.

While the new device will require state-of-the art imaging equipment, Drs. Petty and Elner plan to make it affordable so that it can be used for routine screening of patients at risk for diabetes in a variety of clinical settings.

The rapid, non-invasive test is simple to administer.

The new instrument captures images of cells as they react to stress before structural changes appear. Current clinical methods can detect structural changes only after the disease is already advanced.

“Not often do you have a technology that so radically changes how eye care is delivered,” says Anik Ganguly, acting president, as well as investor in the company. The new instrument is non-invasive, easy to use, and should become a standard feature in every ophthalmology practice.”

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national clinical trial directed by kellogg

Long-term study on glaucoma treatment yields new answers In 1989, researchers at the U-M Kellogg Eye Center set out to determine the best treatment

for patients who were newly diagnosed Coordinating the clinical trial requirements among 14 centers and over 600 glaucoma patients across with glaucoma: eye drops or surgery. the country are Paul R. Lichter, M.D., Carol L. Standardi, R.N., and David C. Musch, Ph.D., M.P.H. They led a national study, the Collaboravisual field data, Dr. Musch has some pertinent take-home tive Initial Glaucoma Treatment Study messages. “For starters, both groups did well. Intraocular (CIGTS), that would ultimately follow the care of 607 pressure reduction from treatment was substantial in both patients at 14 clinical centers around the U.S. Now, after groups, but significantly more so in the surgery group. following these patients for many years, researchers have Visual field loss was less than expected, likely due to the found that the data continue to reveal unexpected findings. superb treatment and follow-up care these patients re Paul R. Lichter, M.D., Principal Investigator on the ceived throughout the trial.” He surmises that the regular original CIGTS grant and Director of the Kellogg Eye clinic visits and frequent calls from Center, was hoping to put the coninterviewers might have encouraged troversy to rest once and for all. “For “It appears that patients the patients to comply better with years, practitioners have wondered who had more visual field instructions and treatment. which initial treatment was better loss at the time of diagnosis There was, quite unexpectedly, an for our patients. Some were sure it was medicine, others were sure it was ultimately do better if they intriguing finding within the surgery arm of the trial. According to Dr. surgery. But there were no data that are treated initially with Musch, the data show that smokcould prove either side.” ers had substantially higher intra Now we have data. With fundsurgery rather than with ocular pressures than non-smokers. ing from the National Eye Institute medication.”

A smoker who underwent surgery for the original grant and a subsefor glaucoma was worse off than a quent grant for data analysis, Dr.

— Paul R. Lichter, M.D. patient in the surgery arm who did Lichter and colleagues have had the not smoke. Whether this has any effect on long-term visual opportunity to follow patients for over a decade. “While field loss remains to be determined. early reports indicated that initial surgery and medications Although Dr. Musch and his colleagues will continue yielded similar outcomes, analyses of longer term follow-up to analyze the data, one finding appears to be indisputable. data have revealed an important result,” says Dr. Lichter.

Intraocular pressure fluctuation is a strong independent “It appears that patients who had more visual field loss at predictor of visual field loss. Thus, consistent control of the time of diagnosis ultimately do better if they are treated pressure remains vital. The better and more reliable the initially with surgery rather than with medication.” pressure control, the less loss of visual field. Pressures that

From the beginning David C. Musch, Ph.D., M.P.H., fluctuate increase the risk that the patient will lose visual has directed what is now a huge database, produced study function. reports, and crunched the numbers. After evaluating the

2007 annual Report

The Hepner family created a popular fundraiser to generate support for vision research. Here with Anand Swaroop, Ph.D. and Paul R. Lichter, M.D., are Myron, Caitlyn, and Karen Hepner with their son, Brendan.

Retina research gets boost

Grateful patients give back with first-time fundraiser

place this past March at Damon’s Grill in Ann Arbor.

During the two-day event, which was heavily

publicized by the local media, Mr. Hepner watched all 32 games and raised $6,000 for Kellogg’s vision research program. Brendan, now a happy and healthy 4-year-old, EVER SINCE THEIR SON, BRENDAN, WAS DIAGNOSED was right alongside him, serving as an inspiration to and treated for retinoblastoma when he was just nine everyone who donated. months old, Myron and Karen Hepner had been looking

Donations were received from individuals and organizafor a way to give back to the Kellogg physicians and staff tions from seven different states (Florida, Illinois, Indiana, who helped them so much.

Michigan, North Carolina, Tennessee,

“The doctors and staff were a shin- “This event provided so and Washington) and from people ing light to us when Brendan’s diagwho have a history of retinoblastoma, many people with the opnosis was made,” says Mrs. Hepner. as well as those who had never heard “Their caring attitude toward us went portunity to express their of this rare disease. far beyond just being patients and we “This event exceeded our wildest support and appreciation have been grateful for their sincerity expectations because it really struck for all the great experiences throughout all the follow-up visits. a nerve with the community,” says They are a blessing to our family.” they have had at Kellogg.” Mr. Hepner. “It provided so many

Over the years, Mr. Hepner has people with the opportunity to ex— Myron hepner gathered with friends to watch the press their support and appreciation NCAA Men’s Basketball Tournament for all the great experiences they have and, during the 2006 tournament, he hatched the idea to had at Kellogg. Kellogg has been a wonderful place for us watch all 32 games of the first round in exchange for donato have Brendan treated,” he adds. We know that all the tions. It was this simple idea that turned into the inaugural great work and research going on there will have a positive March Madness Against Blindness fundraiser that took impact throughout his life.”

university of michigan kellogg eye center

Blind mice can see — or at least regain visual function

What’s the next step in making retinal cell transplantation a reality?

Transplanting retina cells to restore vision

has been an aspiration of vision scientists for years. In November 2006, scientists at the University of Michigan Kellogg Eye Center attracted international attention when they demonstrated that transplantation can be successful if the cells are introduced to the mouse retina at a very particular point in their development.

Anand Swaroop, Ph.D., had devoted many years to investigating the development and life cycle of rods, a type of photoreceptor cell that is essential for sight. Eventually he discovered that each rod starts out as an unspecified stem cell and then evolves into a “precursor,” at which point it signals its intent to become a particular type of cell. When transplanted at its precursor stage, the rod continues to develop and is successfully integrated into the mouse retina.

Some reports claimed that “blind mice could see,” although it would be more accurate to say that these mice had “regained visual function,” as measured by the pupillary response to light.

The research findings immediately A young man struck a chord among people with eye

Anand Swaroop, Ph.D., leads the team that made marked progress on the thorny problem of photoreceptor transplantation.

translated into treatments for degenerative retinal diseases.”

Dr. Swaroop and colleagues will continue to study rod transplantation with the goal of increasing the rate of cell integration. Meanwhile, the Kellogg researcher is directing a new study to ask the next big from Brisbane, question: If rod precursors can be transplanted, why not cones? “The Australia wrote, “Your reearly data suggest we can rescue cone diseases like retinitis pigmentosa, in search holds much promise function,” says Hong Cheng, M.D., which vision loss is caused by the loss Ph.D., researcher in the Swaroop of rod photoreceptors. They emailed and it is hoped that I could laboratory, who spoke at a recent their congratulations and wanted to be a recipient of the technol- Kellogg Research Symposium. know when human testing would Cones are the light-sensing begin. A young man from Brisbane, ogy in the not too distant cells concentrated in the macula.

Australia wrote, “Your research holds future.

Best wishes for your If researchers replicate their success much promise and it is hoped that I could be a recipient of the technolcontinued research success.” and demonstrate that cones, too, can be transplanted, Dr. Swaroop ogy in the not too distant future. Best and colleagues will have good news for people suffering wishes for your continued research success.” from another devastating eye disease: age-related macular

Dr. Swaroop replied with cautious optimism. “It will degeneration. take time,” he said, “to make the transition from mouse

Dr. Swaroop is the Harold F. Falls Collegiate Professor models to human eye disease. Nonetheless, this is a very of Ophthalmology and Visual Sciences. exciting time for scientists who hope to see their research 2007 annual Report

“I chose Kellogg for my residency because of the amazing faculty.

I was so impressed with the depth and breadth of their abilities and experience in all of the subspecialty areas.”

—Deborah Y. Chong, M.D. 10

university of michigan kellogg eye center

Kellogg Trains the Brightest and Best

Co-chief resident looks toward career in academic medicine Every year, Kellogg attracts the brightest and best to its residency program and Deborah Y. Chong, M.D.,

is no exception. After completing both her bachelor’s and medical degrees at Harvard University, she decided it would be wise to experience life in a different part of the country.

She matched with Kellogg and began her residency in 2005.

“I chose Kellogg for my residency because of the amazing faculty. I was so impressed with the depth and breadth of their abilities and experience in all of the subspecialty areas,” says Dr. Chong.

Now entering her final year of residency, she continues to be impressed by the faculty. “One aspect of my residency that I’ve really enjoyed is the support from faculty,” explains Dr. Chong. “Even when one of the residents has to page a faculty member at 3 a.m., they never hesitate to call back immediately and share their expertise. This really shows how dedicated they are to our education and our residency program as a whole.”

Dr. Chong was awarded an NEI Travel Grant to attend the 2007 ARVO Annual Meeting in Florida, where she teamed with Susan G. Elner, M.D., David C. Musch, Ph.D., M.P.H., and fellow resident Tony H. Huynh, M.D., to present a poster on the effects of aspirin on the outcomes of photodynamic therapy. She also is working in the laboratory of David N. Zacks, M.D., Ph.D., on photoreceptor neuroprotection and studying vitreal drug penetration under Mark W. Johnson, M.D. With her combination of clinical skills and research interests, Dr. Chong has made her own impression on the Kellogg faculty. “Dr. Chong is not only one of the brightest clinicians and most talented surgeons I have had the opportunity to work with, but she also is one of the kindest and most humble people I know,” says Shahzad I. Mian, M.D., Kellogg’s Residency Program Director. “She is a star and certainly has a bright future ahead of her.”

Her bright future continues to take shape in 2007-08 when she assumes duties as Co-Chief Resident. “I know I have some big shoes to fill. There is a legacy of strong chiefs to uphold,” says Dr. Chong, who plans to pursue a retina fellowship and then begin a career in academic medicine.

Deborah Y. Chong, M.D., Co-Chief Resident, plans a career in academic medicine after a retina fellowship.

Residency Program Director Shahzad I. Mian, M.D., knows she has a bright future.

2007 annual Report

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Serendipity Sends Four Students to Internships Overseas

Kellogg researcher taps international network A student’s casual question TO JULIA E. RICHARDS, Ph.D., has resulted in overseas internships for four University of Michigan students. Dr. Richards had invited a group of students to her home to socialize and discuss research internships. One guest, a graduate student in epidemiology, Teja Patil, asked Dr. Richards if she knew of any international research opportunities.

Dr. Richards, an ophthalmic geneticist in the Department of Ophthalmology and Visual Sciences and faculty member in the School of Public Health, began to draw on her worldwide network of physicians, researchers, and former students. She quickly found a position for Teja A global network of collaborators enabled Julia E. Richards, Ph.D., to help four students with a researcher in Peru who had been a postdoctoral find internships with vision scientists overseas. fellow at Kellogg in the lab of Anand Swaroop, Ph.D.

The fourth student, Nolawi Taddes, has an interest in Teja’s interest in both laboratory and clinical research, epidemiology studies in Africa. He is on his way to Accra, and her ability to speak Spanish, made her well suited Ghana to work with Christine Ntim-Amponsah, M.D., to work with Ricardo Fujita, Ph.D., in Lima, on the who collaborates with Dr. Richards on the study of the molecular genetics of glaucoma. molecular genetics of glaucoma in

Meanwhile, a medical student The interns will help build West Africa. The genetic information called the Kellogg Eye Center to ask collected there is highly relevant to U.S. about foreign internships and was a database of patient epidemiology studies because a signifiput in touch with Dr. Richards, who characteristics that will cant number of African-Americans, specializes in epidemiology as well who are generally at a greater risk of as ophthalmic genetics. Several more constitute the first good developing glaucoma, can trace their students called and Dr. Richards epidemiologic survey of ancestry to West Africa. It is especially made the additional matches. relevant to families here with known

One of Dr. Richards’ own former glaucoma in Paraguay. relatives in Ghana. postdoctoral fellows, Rosa Ayala And even as our students work in South America and Lugo, M.D., an ophthalmologist in Asuncion, Paraguay, Africa learning how scientific research is conducted in other responded that she had positions for more than one countries, one of the sponsors has sent a student to a student. The medical student, Nisreen Mesiwala, and Kellogg laboratory. Alejandro Estrada Cuzcano, a student of Takayuki Shimizu, M.D., a physician from Japan who is Dr. Fujita from Peru, is here working with Anand Swaroop, studying for his M.P.H. in epidemiology at Michigan, will helping to make the bridge between these countries funcwork in Dr. Ayala-Lugo’s laboratory. Their task will be to tion as a two-way street. help her build a database of patient characteristics that will

constitute the first good epidemiologic characterization of glaucoma and other eye diseases in Paraguay.

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Training technicians

On-the-job clinical experience sets program apart Ophthalmic technicians are an integral component of the clinical team at Kellogg, working

closely with physicians in the evaluation and management of patients with a variety of ocular problems. Because of the critical role they play, only the most competent and highly skilled technicians are asked to join the staff of the Eye Center. Finding this kind of talent has been an increasingly difficult challenge for Jennifer Ziehm-Scott, Clinic Operations Manager at Kellogg. A one-time practicing technician herself, she has witnessed the demise of many ophthalmic technician training programs across the country over the past decade.

Because the need is great and the pool of qualified candidates small, Ms. Ziehm-Scott teamed with Amy Steele, Lead Technician in Kellogg’s Comprehensive Ophthalmology Clinic, to develop an in-house training program for ophthalmic technicians. The program was established on a trial basis four years ago and became official in 2006.

Training for this six-month program begins with Ms. Steele in the Comprehensive Clinic, which tends to be the first stop for many new Kellogg patients. It offers trainees the opportunity to see a wide variety of ocular conditions.

The trainees also work with physicians who understand that they and their patients will benefit directly from the assistance of a highly competent technician. Ms. Steele observes that this kind of physician involvement makes for a great learning environment.

During the first few months of the program, the trainee reviews written material and learns basic skills like vision testing and taking patient histories. In the next few months, technicians in one of Kellogg’s subspecialty clinics will introduce the trainee to procedures and diagnostic tests typically administered for patients with more complex diseases.

By the end of the program, the trainee will be shadowing a physician and tracking patient visits from beginning to end.

“The program we’ve created at Kellogg has the benefit of on-the-job, clinical training, which many formal programs lack,” says Ms. Steele. “I’ve heard from trainees and

established technicians that this is one of the most valuable parts of our program.” She also observes that both staff and physicians have the opportunity to spend one-on-one time with the trainees, getting to know them and finding out if they will be a good fit for Kellogg.

To qualify for training, a candidate must have completed two years of college and have a health care or science background. After completing the program, the technician joins the Kellogg staff and makes a two-year commitment. After one year (or 1,000 hours), he or she has the opportunity to become a Certified Ophthalmic Assistant (COA) by taking the national examination. To date, seven trainees have completed the program and four of them have gone on to pass the COA exam. The remaining three trainees will take the exam this year.

Typical of the intense one-on-one training, Amy Steele, C.O.T., demonstrates the proper use of the hand-held keratometer to Karen Schneider.

2007 annual Report

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Martha M. Wright, M.D. Associate Professor, Director, Glaucoma Service, and Director, Ophthalmology Residency Program University of Minnesota Department of Ophthalmology Completed residency in 1988

Patrick J. Parden, M.D. Private practice, Coeur D’Alene Eye Clinic Coeur D’Alene, Idaho Completed residency in 1984 The wide range of cases Dr. Parden saw as a resident at U-M prepared him for

Spending time as a volunteer in India

the variety of patients he has in Coeur D’Alene, a growing community in northern Idaho, and on surgical missions to Mexico, Guatemala, and China. “The most rewarding part of eye practice is the positive impact that we have on our patients’ quality of life,” he says. “We also have a tremendous opportunity to help abroad.”

and Nepal just after her residency gave Dr. Wright a perspective that continues to influence her. “It was a wonderful experience in which I learned more than I taught and received more than I gave,” she says.

Today she especially enjoys establishing relationships with patients and training residents.

Kimberly G. Yen, M.D. Assistant Professor of Ophthalmology and Pediatrics Baylor College of Medicine Houston, Texas Completed residency in 1999

William Selezinka, M.D. Retired San Diego, California Completed residency in 1973

As a pediatric ophthalmologist, Dr. Yen participates in a number of NIH-funded clinical trials, including work on retinopathy, amblyopia, nasolacri-

Instrumental in establishing the

mal duct obstruction, and congenital cataracts. Her responsibilities

Ukrainian Eye Project after the fall of

include educating residents, fellows, and medical students, helping

the Soviet Union, Dr. Selezinka says simply that he was “just doing what I like to do.” With Dr. Selezinka serving as the project’s medical director, the 15-year effort has resulted in 500 surgical procedures and has

others achieve their career goals just as faculty members at the Kellogg Eye Center assisted her. “My mentors helped me get where I am today,” she says.

provided more than $2 million of donated ophthalmic surgical supplies, equipment, and medicines as well as invaluable training for Ukrainian physicians in Ivano-Frankivsk, Ukraine.

It serves as a model for other medical outreach programs.

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university of michigan kellogg eye center

Training Leaders Gives Kellogg Worldwide Reach

Brian P. Brooks, M.D., Ph.D. Director, National Ophthalmic Disease Genotyping Network at the National Eye Institute and Director of the Ophthalmic Genetics Clinic at the Children’s National Medical Center Washington, D.C. Completed residency in 2001, fellowship in 2002 One of only a handful of physicians in the country who is board-certified both by the American Board of Medical Genetics as well as the American Board of Ophthalmology, Dr. Brooks is leading the nationwide effort to create a repository of DNA samples from patients with inherited eye diseases, called the National Ophthalmic Disease Genotyping Network, or eyeGENE. “Our hope is that this network will empower patients and their physicians with molecular genetic knowledge,” he says.

Hideki Chuman, M.D., Ph.D. Associate Professor of Ophthalmology University of Miyazaki Miyazaki, Japan Completed fellowship in 2001

Keith D. Carter, M.D. Chair, Department of Ophthalmology and Visual Sciences University of Iowa Iowa City, Iowa Completed residency in 1987

As a respected neuro-ophthalmologist, Dr. Chuman sees patients from a wide geographic area. He also gives frequent lectures and serves as the neuro-ophthalmology section editor for the Japanese Journal of Ophthalmology. “My time at the University

After serving as both medical director of

of Michigan made a difference in my career,” he says. “Many oph-

clinical services and director of resident education at the University of Iowa, Dr. Carter was tapped last year to lead the department of more than 30 clinicians and scientists.

thalmologists know I have been well trained and are comfortable sending their patients to see me.”

“It is an honor to help direct this talented group of individuals,” says Dr. Carter, a specialist in oculoplastic surgery. His own research interests include Graves eye disease, inflammatory orbital disease, anophthalmic socket reconstruction, and predictive factors for eyelid reconstruction.

More than 500 alumni in the United States and around the globe are making a difference in the lives of people with eye disease.

Those profiled here offer a snapshot of that impact.

2007 annual Report

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“Genetic counselors are trained to explain these complex, scientific issues to people in a way that will help them understand more about their disease.� —Kari E. Branham, M.S.

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university of michigan kellogg eye center

GENETIC COUNSELORS ARE ADVOCATES FOR PATIENTS and their families

Kellogg’s counselors give patients a short course in genetics There are only 10 ophthalmic genetic counselors in the United States and two of them reside at Kellogg. According to Kari Branham, M.S., Kellogg’s

comes to sharing the most up-to-date information on their disease, and I’m there to help them find the support they need.”

Kellogg’s genetic counselors see about 400 patients per year. They also work with clinicians and genetic counselors throughout the country to help patients get the information they need. In addition, they are involved heavily in research and clinical trials.

Donald Moore, 64, has been diagnosed with Stargardt disease—a disease characterized by progressive loss of central vision. He is one of many patients who find Kellogg’s genetic counseling valuable. “I am so surprised that other

lead genetic counselor, genetic counseling is an integral part of caring for patients who have inherited retinal diseases.

“Genetic counselors are trained to explain these complex, scientific issues to people in a way that will help them eye centers don’t have counselors to help patients with their understand more about their disease,” says Ms. Branham. diseases,” says Mr. Moore. “Having genetic counselors

Most of the patients Ms. Branham sees are referred really increases a person’s confidence in an eye center.”

by Kellogg retina specialist John R. Heckenlively, M.D.

Currently, Mr. Moore’s vision is stable and he visits They see Ms. Branham as part of their comprehensive Kellogg once a year for a routine eye examination. He first visit. During a typical appointment, Ms. Branham hopes to see a cure for his disease in his lifetime and says, talks with patients about their diagnosis and reviews if that happens, he believes that Kellogg will have played a information about their disease. She also explains how the key role in the discovery. “I’ve never heard of an eye center disease is inherited and informs them of available genetic more on top of these diseases,” says Mr. Moore. “I have a testing, describing its benefits and limitations. Lastly, she feeling they’re going to solve the next big thing.” spends time talking about how to understand the genetic test results.

Ms. Branham explains that some patients will decide to have testing even though treatment is not yet available for many inherited eye diseases. They may figure that the results will help them make career or lifestyle decisions and that a genetic diagnosis will provide the information needed when treatments begin to emerge.

If patients proceed with genetic testing, the analysis takes place in Kellogg’s state-of-the-art Ophthalmic Molecular Diagnostic Laboratory. The services include Ms. Branham’s on-site genetic counseling, both before and after the testing.

“I like to think of myself as an advocate for my patients,” says Ms. Branham. “I am their resource when it Donald Moore has a greater understanding of his disease after speaking with genetic counselor Kari Branham.

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how the composite image was created

Capturing a sharp and seamless image of the inner eye A good ophthalmic photographer can illuminate images of

the eye’s interior, providing the ophthalmologist with important details about the structure of the eye and the health of a patient’s vision. The Kellogg Eye Center has an outstanding group of ophthalmic photographers, and they are directed by Richard E. Hackel, C.R.A., FOPS. He has won In 1995 Richard Hackel, C.R.A., changed the way we view complex images of the retina. numerous national awards for his work, edits a column in EyeNet, and a little If that takes 3 to 4 hours, it’s still better than the 60-plus over ten years ago, developed an imaging technique that hours I spent on the very first image.” changed the nature of ophthalmic photography.

Mr. Hackel and colleagues Robert Prusak and Linda

Ophthalmic photographers produce detailed images Goings photograph the eyes of 30 to 60 patients a day. of the retina, optic nerve, and other structures that may They know that a large part of their job is to help patients reveal the course of a particular disease. However, photos feel comfortable as they enter an unfamiliar setting. taken through the patient’s pupil capture only a small part “Patients are often afraid and worried about their vision,” of the whole, much like the limited view of a room as seen he observes. “The photos are unlike any they’ve seen through a keyhole. Photographers traditionally pasted mulbefore, so it helps to explain what appears on the tiple images together, but the process left visible edges and computer screen.” a less than perfect image.

The academic setting creates another set of challenges.

Richard Hackel’s achievement in 1995 was to stitch While Mr. Hackel provides images for case presentations together some 92 images to create one clear seamless and journal articles, he is also involved in research, image. The result: the first digital composite of the retina. including the current Kellogg initiative to develop the

“I was on vacation when I received the images for first metabolic imaging device (see related story on p. 6). the cover of a journal I was editing at the time,” says

Then there is the constant need to keep pace with Mr. Hackel. “I spent the better part of the week scanning the newest technology. The Department will soon have digital photos and then piecing them together with high-speed spectral domain imaging equipment that will a software imaging program.” Word spread quickly, and software developers responded by adding a montage feature to imaging software.

With today’s software the process is much simpler.

“You can create a fairly good composite rendering in 5 to 10 minutes,” explains Mr. Hackel. “But the image will be much more useful if you spend the extra time refining it.

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display three-dimensional cross-sections of the retina in exceptional detail. When Eye Center clinics move into a new facility in 2010, Mr. Hackel and his staff will occupy a newly designed photography lab equipped with state-ofthe-art equipment to serve Kellogg’s patients and faculty.

university of michigan kellogg eye center

recognizing Pediatric Glaucoma

A grandmother’s concern and a physician’s expertise help save a baby’s vision When people commented on her baby grandson’s big blue eyes, Audrey Smith felt uneasy. From the time Jackson was born,

she had worried that the eyes everyone noticed looked different than other children’s eyes. In addition to being big, they were cloudy and had a film over them, she says. She finally suggested that her daughter-in-law ask Jackson’s doctor about it.

Maya Eibschitz, M.D., performed successful glaucoma surgery on Jackson Smith, seen here with his mother, Sharen.

“I kept watching his eyes, because I had never seen anything like that before,” she says. says Dr. Eibschitz, who is one of just a few dozen pediatric “I wanted them to be checked.” glaucoma specialists in the country.

Mrs. Smith, who has glaucoma, never dreamed Jackson

Jackson was in that successful majority, Dr. Eibschitz might have a congenital form of the disease. The child’s reports. “He is doing very well. His vision is normal, parents took him to see his pediatrician, who then referred his intraocular pressures are normal, his corneal edema him to the Kellogg Eye Center, where the condition was has resolved, and his optic nerve cupping has returned diagnosed. to normal.”

In pediatric glaucoma, pressure builds up in the eye and

His parents, Sharen and Almount Smith, are grateful can damage the eye and lead to vision loss. The key sympto Dr. Eibschitz and Jackson’s grandmother. “We thought toms include pain, abnormal sensitivity to light, tearing, his eyes were beautiful,” Sharen Smith says. “We just enlarged corneas, and redness of the eyes. Jackson’s tests didn’t know.” revealed high intraocular pressure, corneal swelling, and signs of optic nerve damage, says Maya Eibschitz, M.D., a pediatric glaucoma specialist in Kellogg’s Skillman Children’s Eye Care Clinic.

Primary congenital glaucoma is relatively rare, appearing in only one in 10,000 births. “But when that one patient walks into your office, prompt diagnosis and treatment are crucial to preserving vision,” Dr. Eibschitz says.

Jackson had surgery at the age of five months, the day after he was seen in the clinic.

While adults with glaucoma usually try medication to lower intraocular pressure first, the primary course of treatment for infants is typically surgery to improve drainage in the eyes. The success rates for such surgeries in infants are as high as 75 percent to 95 percent. But children have to Audrey Smith, Jackson’s grandmother, is delighted that her grandson is doing so well. be followed closely by their physicians after an operation, 2007 annual Report

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During a trip that was “not only gratifying but enlightening,�

Dr. Del Monte performed multiple surgeries, including a complex procedure for a mother and son suffering from a rare genetic syndrome. —Monte A. Del Monte, M.D. 20

university of michigan kellogg eye center

rare eye muscle syndrome treated

Kellogg Expert Takes Eye Care to Guatemala Among the many surprising moments for Monte Del Monte, M.D., on a recent trip to Guatemala

was his encounter with a family who had a rare hereditary syndrome. Dr. Del Monte, the Skillman Professor of Pediatric Ophthalmology at the U-M Kellogg Eye Center, traveled under the auspices of the World Eye Mission for a week of teaching, examining patients, and performing strabismus surgery to correct vision problems related to abnormal eye alignment. He visited two hospitals in Guatemala City and one in the Petén, a remote jungle region of northern Guatemala.

The family had a hereditary syndrome known as congenital fibrosis of the extraocular muscles type 1. The mother and son had severely limited visual function due to restrictive strabismus, in which the already misaligned eyes have such limited movement that affected individuals must assume abnormal and uncomfortable head positions in order to see. Because corrective surgery is complex and not available in Central America, the family accompanied Dr. Del Monte to the Petén, where he performed the complicated procedure. The surgery was successful in establishing eye alignment and in improving the range of eye movement—and thus vision—in both patients.

In a fortuitous coincidence, Dr. Del Monte has been involved with a research project that isolated the gene for one form of the syndrome. He sent blood samples to the laboratory of his long-time collaborator Dr. Elizabeth Engle at Harvard Medical School. If the gene affecting this family can be identified, Dr. Del Monte will have contributed useful knowledge about a region where little is known about genetic patterns of this disorder.

The entire trip was, according to Dr. Del Monte, “not only gratifying but enlightening.” At the Visualiza Clinic in Guatemala City, Dr. Del Monte examined 15–20 clinic patients, and performed or assisted in half a dozen eye muscle procedures in a surgical suite within the clinic.

At his second stop in Guatemala City, Roosevelt Hospital, Dr. Del Monte spent a great deal of time work-

Edwin Arias, M.D., (left) and Monte Del Monte, M.D., (center) explain how they will treat congenital cataract to this baby’s mother.

ing with the local residents. They presented complicated cases at a special Grand Rounds and also assisted Dr. Del Monte in the surgical procedures performed at that hospital. In the evenings, Dr. Del Monte led teaching conferences and presented several lectures each night, which often led to lengthy question-and-answer sessions, especially concerning those procedures that were new to this part of the world.

After leaving Guatemala City, Dr. Del Monte traveled to the remote northern province of Petén to visit the stateof-the-art Vincent Pescatore Eye Clinic, a unique clinical model for developing countries. The clinic has two fee structures: the revenue from “private” patients helps fund care for “social” patients who are unable to pay. The care, of course, is the same. This model is being duplicated in other countries in Central America, including Nicaragua and El Salvador.

At the Pescatore Clinic, Dr. Del Monte examined strabismus patients, children and adults, and performed surgeries assisted by one of his hosts, Dr. Edwin Arias. Despite being the only eye clinic in this poor jungle area, the rural Pescatore Eye Clinic was observed by Dr. Del Monte to be “well equipped with most modern instruments and supplies so I needed to bring only a few specialized instruments and sutures.” He added, “This clinic really did have almost anything you would need.”

Board members of the World Eye Mission were instrumental in arranging Dr. Del Monte’s travels. They are President Jeevak Lal, M.D., an Albion, Michigan ophthalmologist and Bartley R. Frueh, M.D., eye plastics specialist at the Kellogg Eye Center.

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“I have been able to thrive in this environment, and I want to help Kellogg continue as a center of excellence.”

—Bartley R. Frueh, M.D. 22

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Legacies of love, achievement

Physician honors parents by establishing professorship fund

engineering from Cornell University before deciding to attend medical school at Columbia University. He completed his ophthalmology residency at U-M in 1970 and served as the Director of Ophthalmic Plastic and Reconstructive Surgery at the University of Missouri Medical Center from 1971 to 1979. He then returned to U-M to start the Eye Plastics and Orbital Surgery Service. Under his leadership it has grown to four ophthalmologists. His own research has sought to define the uniqueness and the properties of eye movement muscles, including the eyelid lifting muscle.

Cheryl Frueh also has a long history with the Kellogg Eye

While neither of Dr. Bartley R. Frueh’s parents attended college, they both valued education and knowledge—and they imparted the importance of both to their children. Dr. Frueh, a Professor of Ophthalmology and Visual Sciences, and his wife, Cheryl, have decided to honor those values by establishing a fund to create the Lloyd and Virginia Frueh Research Professorship in Eye Plastics and Orbital Surgery at the University of Michigan. Dr. Frueh’s father, Lloyd, a business owner, passed away in 1994. His mother, Virginia, lives in Massachusetts.

“When I was growing up, I thought everyone’s parents were like mine, but I realized later that I was extremely lucky,” Dr. Frueh says. “My parents taught me values, integrity, and independence, and they always supported my decisions.”

“They wanted their children to be Lloyd and Virginia Frueh successful and happy,” adds Cheryl Frueh, an occupational therapist and a consultant with Vision Care, Inc.

Dr. and Mrs. Frueh will contribute to the professorship until it is fully funded. They hope it will then serve as a tool to enable the Department to recruit outstanding physicians who are interested in research, Dr. Frueh says. “One of the goals of academic medicine is to advance the field and ask, ‘How can we do what we do better?’ Only through asking questions and examining data to answer those questions can we push the boundaries forward.”

Dr. Frueh earned an undergraduate degree in chemical

Center. Hired as an ophthalmic technician in 1984, she later became an occupational therapist and added this new skill to Kellogg’s low-vision program.

“I have been able to thrive in this environment,” Dr. Frueh says, “and I would like to see it continue as a center of excellence.”

Ultrasound pioneer grateful for support A national pioneer in the use of ultrasound in ophthalmology, Michael A. Wainstock, M.D., led the ultrasound unit within the University of Michigan’s Department of Ophthalmology and Visual Michael Wainstock, M.D. Sciences for close to 25 years.

Through a bequest, he will establish the Michael A. Wainstock Collegiate Professorship in Ophthalmology and Visual Sciences, which will commemorate his groundbreaking contributions to the field of ophthalmology and support the work of a tenured faculty member at the Kellogg Eye Center in perpetuity. “I was trained in the use of ultrasound in Vienna in 1965, and the University of Michigan was very supportive when I wanted to help introduce this new technology in the United States,” Dr. Wainstock says. “The staff and faculty were wonderful to work with, and I feel very good about giving back.”

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Groundbreaking Moment, Groundbreaking Year

September event ushers in era of growth; state-of-the art building designed to facilitate the best in patient care, research, and education Fall winds and the threat of rain didn’t dampen the spirits of the more than 300 people who gathered at

the W.K. Kellogg Eye Center groundbreaking ceremony in September. The event drew donors, alumni, faculty, staff, and University of Michigan leadership to celebrate what had been achieved and to look ahead to new milestones.

“The groundbreaking served to commemorate the work that has gone into this project and acknowledge the work yet to be done,” says Paul R. Lichter, M.D., Chair of the Department of Ophthalmology and Visual Sciences.

An endeavor that will cover more than a decade from start to finish, the expansion effort grew from a 1999 faculty assessment of how the Department could best meet the

needs of a growing patient population and enable a successful research program to reach its full potential. Projections showing an increasing need for ophthalmology services and strong donor support demonstrated to the University of Michigan Board of Regents that the project could succeed.

The Regents approved plans to go forward in 2006, and more than half of the $20 million fundraising goal for the new building had been pledged by the time construction began.

The 230,000-square-foot addition to the current Kellogg tower will increase by 50 percent the space available for patient care, research, and medical education. It will house all patient care clinics and operating rooms as well as new suites for refractive and cosmetic surgery. It will include innovatively designed space for vision research.

And it will be the home of the Delores S. and William K. Brehm Center for Type 1 Diabetes Research and Analysis.

“When the new building opens in 2010, it will be the culmination of years of dreaming, planning, and dedicated effort on the part of many individuals,” Dr. Lichter says.

“This facility will enable us to continue to make strides in vision care for decades to come.”

Among the dignitaries at the September 19th groundbreaking ceremony were Robert Kelch, M.D., Regent Olivia Maynard, Bill Brehm, Dee Brehm, Regent Rebecca McGowan, Paul Lichter, M.D., and Mary Sue Coleman, President of the University of Michigan.

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university of michigan kellogg eye center

Architectural rendering of the Kellogg Eye Center Expansion.

Fisheye view from the roof after ground is prepared in March.

Eye Center Expansion Honor Roll of Donors The following individuals and organizations have made gifts and multi-year pledges in support of the expansion of the Kellogg Eye Center. We recognize their gifts here with deep appreciation. These contributions will help us provide the best in patient care, conduct groundbreaking vision research, and train the next generation of ophthalmologists and vision scientists. $2 million and up Edwin E. and Mary U. Meader

$1,000,000 to $1,999,999 Lynn H. and Robert W. Browne, D.D.S. Richard and Jane Manoogian Larry G. Miller Harold and Marian Poling Helmut Stern Robert and Ellen Thompson

$500,000 to $999,999 John F. and Casilda Daly

$250,000 to $499,999 Mickey and Karen Shapiro Timothy and Laurie G. Wadhams

$100,000 to $249,999 Anonymous Donor Frank J. and Helga Arnold Charles and Rita Gelman

Johnson Controls Foundation Carolyn and Paul Lichter ✧ Keith and Della McKenzie ✧ Charles and Kathleen Smith ✧ David and Jayne VerLee ✧ Mary June and William Wilkinson ✧

$50,000 to $99,999 Steven and Constance Benz ✧ Anne and Terry J. Bergstrom ✧ Dave and Yvette Bing Thomas C. Brown James and Martha Conrad ✧ William and Carol Cutler ✧ Ruth B. Dixon Robert and Cassandra Estes ✧ Douglas and Shelley Felt ✧ Vincent and Joyce McLean James and Nancy Ravin ✧ Rennie and Michael Roth ✧ Alan and Gail Sugar ✧

2007 annual Report

$25,000 to $49,999 Anonymous Donors ~ 2 James and Kathryn Adams ✧ Herbert and Carol Amster Joe and Beth Fitzsimmons Richard and Lisa Garfinkel ✧ Larry and Mary Gerbens ✧ Orpha Irwin Helen and Richard Kerr Kim Lindenmuth and Matthew Bueche ✧ Roger Meyer and Judy Gordon ✧ John and Phyllis Napley Michael Petersen and Elizabeth Binasio ✧

$10,000 to $24,999 Alfred Berkowitz Foundation Seth Bonder George and Connie Cress Dow Chemical Company Foundation Robert and Megan Fante ✧ David Gavrin Harry and Mary Gibson ✧ Paul and Lillian Gieser ✧ James and Charlene Glerum John Heckenlively ✧ Virginia Hickman Robert and Joan Hughes KALSEC Corporation W.R. Kenley Robert and Mary Kiess

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Concrete being poured to form part of the foundation.

Column piers (vertical) sit atop column footings (horizontal) and form the weight-bearing structures of the new building.

Eye Center Expansion Honor Roll of Donors $10,000 to $24,999 - cont’d James and Carolyn Knaggs ✧ Carol L. Makielski and Charles D. Lake ✧ Masco Corporation Donald and Jacqueline McCulloch Dean and Lynn Mitchell ✧ Andrew and Cathryn Moyes ✧ Stanley and June Oleksy ✧ U.E. Patrick James R. Quinn ✧ Michael and Debra Raizman ✧ James and Helen Reader Franklin and Marilyn Sassaman ✧ Earl and Helen Schaper Perry and Faith Schechtman ✧ Michael and Linda Smith-Wheelock ✧ Susan and David Thoms ✧ Alfred and Carol Wick ✧ W. Scott and Jill Wilkinson ✧

$5,000 to $9,999 Everton and Saundrett Arrindell ✧ Nancy Bender Donald and Christine Beser ✧ Robert and Jennie Biggs ✧ Garry and Gretchen Binegar ✧ Fred and Miriam Blum ✧ Ralph and Kay Crew ✧ William and Gloria Dean

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Andrew and Margaret Hanzlik ✧ John and Joyce Henderson ✧ Peter and Karla Hitchcock ✧ Mark and Linda Johnson ✧ Metaldyne New England Eye Center Venkat and Alvira Reddy ✧ H. Kaz Soong and Barbara Nevins-Soong ✧ Danny and Yili Liu Wang ✧

$1,000 to $4,999 Steven and Carol Archer ✧ James and Martha Barnett ✧ Edward and Martha Boggs William and Julie Bromley ✧ Bruce Cameron ✧ William and Janet Cassebaum The Cornblath Family ✧ Deborah Cox ✧ Kristen and Monte Del Monte ✧ Thomas and Susan Essman ✧ Francis Falck ✧ Judith FitzGerald and Robert Glinert ✧ Philip Gage and Wendy Rampson-Gage ✧ Dasa and Nalini Gangadhar ✧ Edward and Carol George ✧ Jon and Sarah Gieser ✧ Robert Goldsmith ✧ Daniel and Norma Green ✧

university of michigan kellogg eye center

Robert and Carolyn Hoffman ✧ Bret and Laura Hughes ✧ David and Patricia Johnson ✧ Robert Keil Key Foundation Kirk and Constance Lignell ✧ Benard L. Maas Foundation James Maraldo Marvin and Beverly McKenney ✧ Shahzad Mian and Uzma Ahmad ✧ Sayoko Moroi and Michael Fetters ✧ Christine Nelson and Willis Lillard ✧ Betsy and Kenneth Nisbet ✧ Dr. and Mrs. Mohammad Othman ✧ Mark and Kimberly Phelan ✧ Douglas and Sheryl Podlewski ✧ Donald and Debra Puro ✧ Julia Richards and Carl Marrs ✧ Marcia and David Schmidt ✧ Tara Schmitt and Chris Palumbo ✧ Carol and Irving Smokler Carol Standardi ✧ Richard and Joyce Toner Peter and Adele Vaculik Margaret Vezina Richard and Edith Wacksman ✧ Randall S. and William K. Wallach ✧ Richard and Kay Watnick ✧ Adrienne West and Mark Hemmila ✧

The 249-ton crane arrives on site and is put together in June.

Fully extended 394’ crane in front of the Kellogg Eye Center Research Tower.

Eye Center Expansion Honor Roll of Donors $500 to $999

up to $500

William and Elizabeth Arendshorst ✧ Eric Arnold ✧ Frederick and Jean Birkhill Steven and Jacqueline Boskovich ✧ Christina Bruno ✧ MargaretAnn Cross ✧ Gayle D. Dickerson ✧ Carolyn and David Diles Greg and Dottie Dootz ✧ Jerome and Polly Finkelstein ✧ Martin and Risé Goode William Hawkins Reid and Donna Johnson Richard Alan Lewis and Patricia N. Lewis ✧ Richard Rodman and

Patrice Bouzan-Rodman ✧ Stephen and Kim Saxe ✧ Warren and Nancy Scherer ✧ Barney and Geraldine Schwartz Atta Rae and Gabriel Sitrin E. H. Newel and Rosemary Smith ✧ Thomas and Jane Stratford ✧ Scott Szalay ✧ Debra Thompson and William Strong ✧ Jeanne K. Walters Ronald Warwar ✧ Beverly Yashar and John Mesberg ✧ David Zacks and Susan Harris ✧

Cynthia Abejuro ✧ Katherine Augustaitis ✧ Mike Bergiel ✧ Samir and Mona Binno Renee Blosser ✧ Carolyn and Leonard Bohm Marcia J. Boynton ✧ Lisa Burkhart and Frank Hunt ✧ Beverly A. Conkle ✧ Donna Duffy ✧ Darlene Fero Elena Filippova ✧ Bruce and Susan Furr ✧ Chad and Courtney Godfrey ✧ Dr. Edward and Ms. Patricia Hall ✧ Naomi and Theodore Harrison Margaret Hartz Honorable and Mrs. R. James Harvey Joseph and Lori Hymes Walter Ingram Robert and Joan Jampel ✧ Athanasios J. Karoukis ✧ Adabelle Knief Judith Knitter ✧ Piyush and Sarla Kothary ✧ Susan Lichter Michael and Judy Lipson ✧ Susan Ludwig ✧ James and Gay McGuckin ✧

2007 annual Report

Midwest Transmission, Inc. Victor and Kendra Monroe David and Benita Murrel Dave and Jan Musch ✧ Ajay Natarajan and Ritu Khanna ✧ Olga Nelson Gale and Yehuda Oren ✧ Hemant Pawar ✧ Rebecca and Paul Pazkowski ✧ Carol J. Pollack-Rundle and Family ✧ Frank Rozsa and Szonja Puskas-Rozsa ✧ Mr. Ross and Mrs. Shannan Saltz ✧ Cindy Shaffran Susan and Gary Simpson ✧ Camille S. Smith ✧ Jeanne F. Smith ✧ Amy Steele ✧ Norma and Gene Stohler Anand and Manju Swaroop ✧ James B. Thompson Jonathan Trobe and Joan Lowenstein ✧ Molly and Robert Wheaton ✧ Alyce Whipp ✧ Kim Wisniewski ✧ Anthony Wojciechowski Jennifer Ziehm-Scott ✧ ✧ Faculty, staff, and alumni donors We make every effort to ensure the honor roll is as accurate as possible.

Please let us know if you note any errors.

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Partners in Vision Early leadership gifts key to moving forward The ability to break ground on the Kellogg Eye Center expansion took many years of planning and dedicated effort from faculty and staff. It also required a strong showing of support from the community. The expansion campaign received seven early-stage leadership gifts, which enabled construction to begin. The foresight and dedication of the following individuals has been crucial to reaching this point:

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Lynn H. and Robert W. Browne, D.D.S. Dr. and Mrs. Browne have a long history of supporting growth at the University of Michigan. Having earned a D.D.S. and a master’s degree in orthodontics from the U-M School of Dentistry, Dr. Browne practiced in Grand Rapids for 20 years. He also founded Care Corporation, a publicly held long-term care company. Today he is CEO of Trust Investment Management Corporation.

Making a gift to the Kellogg expansion is a smart investment, Dr. Browne believes, because of the Eye Center’s strong leadership and successful research program. “You can’t invest in something that will pay more dividends than the work being done at Kellogg,” he says. “The research and care is second to none, and I hope it will benefit my children and my grandchildren. Loss of vision is not lifethreatening, but it is a quality of life issue and something we all face as we get older.”

Among other gifts to the University of Michigan, the Brownes have established the Robert W. Browne Orthodontics Wing at the School of Dentistry and have endowed professorships and scholarships.

university of michigan kellogg eye center

Richard and Jane Manoogian

Edwin E. and Mary U. Meader

Pleased to support a facility dedicated to preserving sight, Mr. and Mrs. Manoogian have made a leadership gift to the Kellogg Eye Center expansion campaign.

Mr. Manoogian is the Executive Chairman of Masco Corporation. Founded in Detroit in 1929 by Mr. Manoogian’s father, Alex Manoogian, today Masco is a $12.8 billion corporation that globally provides branded products and services for new residential construction and home improvement. Mr. Manoogian is also a Director of Ford Motor Company as well as JPMorgan Chase & Co. The Manoogians are active in numerous civic, cultural, and educational organizations. They have generously hosted two special events for the Kellogg Eye Center at Masco headquarters, inviting guests to view their art collection, which is commonly referred to as one of the best private collections of American art formed in this century. The most recent event, a Celebration of Achievement for the Department’s faculty, took place in April.

“I am motivated to support the Eye Center because I saw what macular degeneration did to reduce my father’s quality of life in his later years,” says Mr. Manoogian.

“Sight is our most precious sense, and supporting one of the world’s best centers for eye care and vision research is how I can play a role in working to cure this devastating disease.”

Mr. and Mrs. Manoogian’s philanthropic efforts also include major contributions to the Detroit Institute of Arts, the Detroit Zoological Society, the Barbara Ann Karmanos Cancer Institute, the College for Creative Studies, The Henry Ford, and the St. John Hospital and Medical Center.

Mr. and Mrs. Meader are longtime supporters of the Kellogg Eye Center. Their most recent gift supports the expansion and will provide for naming the lobby of the new building.

Over the years, the Meaders have also made major gifts that have resulted in significant growth in the Eye Center’s research program. They established the Paul R. Lichter Professorship in Ophthalmic Genetics, which supported the genetic studies of Dr. Paul Sieving, who today is the director of the National Eye Institute. Dr. John Heckenlively, an internationally recognized retina specialist, today holds the chair. The Meaders also created the Edwin E. and Mary U. Meader Vision Research Fund.

The Meaders’ generosity extends throughout the University of Michigan, from which Mr. Meader graduated with a degree in geography in 1933.

Their gifts have been wide-ranging, including support of the Depression Center, the Kelsey Museum of Archaeology, the Departments of Chemistry and Psychiatry, the School of Music, and Hill Auditorium. The University and the Eye Center lost a true friend when Mr. Meader passed away on February 1.

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Larry G. Miller

Harold and Marian Poling

Mr. Miller made a leadership gift to the Kellogg Eye Center at a key moment in the building campaign—just after the University of Michigan Regents had approved the project.

“Eyesight is such a critical part of our lives,” Mr. Miller says. “I’m pleased to be able to make research possible— and better.”

Mr. Miller was a founding partner of Molmec, Inc., a major supplier of molded plastic components for the automotive industry. When the company was sold in 1997, it had grown to 1,000 employees and five manufacturing plants in Michigan. Mr. Miller earned a bachelor’s degree and a master’s degree from the U-M College of Engineering, where he was awarded one of the first degrees in materials engineering.

Mr. Miller’s gift to Kellogg grew out his own experience at the Eye Center. He happened to meet Dr. Paul Lichter after he developed double vision, and Dr. Lichter encouraged him to make an appointment. After being successfully treated at Kellogg, Mr. Miller accepted Dr. Lichter’s invitation to tour the facility. “My support comes from a personal connection to individuals, and then having the opportunity to learn about the needs of the Eye Center,” he says. “When I toured the research laboratories with Paul, I could see how crowded the facilities had become. It seemed that the time was right to contribute to the growth of the research program.”

In addition to his gift to the Kellogg Eye Center, Mr. Miller has also supported the U-M College of Engineering and the U-M Cancer Center.

Stalwarts in the area of health care philanthropy, Mr. and Mrs. Poling have made a generous gift to the Kellogg Eye Center expansion.

Mr. Poling retired from his position as Chairman of the Board and Chief Executive Officer of Ford Motor Company in 1993 after a long and distinguished career with the automaker. Today he is Chairman of Eclipse Aviation Corp., serves on the board of Beaumont Hospitals, and helps guide numerous other businesses and organizations.

During a tour of the Eye Center, Mr. Poling met several faculty members doing scientific and clinical research aimed at finding more effective treatments and cures for eye disease. He was particularly impressed with the gene microarray studies being conducted, which allow scientists to investigate thousands of DNA segments at once. The Kellogg Eye Center was one of the first ophthalmology departments in the country to be granted funding from the National Eye Institute to create a gene microarray facility.

“I hope our gift will help Kellogg researchers keep advancing vision research,” says Mr. Poling, citing his high regard for the University of Michigan as a key reason for his support.

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university of michigan kellogg eye center

Helmut Stern

Robert and Ellen Thompson

Mr. Stern, an Ann Arbor businessman and philanthropist, has been helping to lead the Kellogg Eye Center’s expansion campaign since its inception. Chairing the Community Advisory Board that guided the first steps of the effort as well as giving a major gift to the campaign, Mr. Stern was instrumental in building the support that ushered the Eye Center from an idea to reality.

Mr. Stern is President of Arcanum Corporation. He generously supports numerous schools and projects at U-M, and he believes in bolstering the university’s excellence as a whole. An avid art collector, he has been a major benefactor of the U-M Museum of Art. He has also endowed professorships in Chinese Studies and Humanities and has created scholarships for the College of Literature, Science, and the Arts, Rackham Graduate School, the School of Engineering, and the School of Public Policy. His philanthropic efforts are driven by his interests, but also by recognizing strong leadership, he says. “I get motivated primarily by the quality of the people involved.”

With Kellogg’s top-notch ophthalmologists, scientists, and leadership team, it is important to think beyond the new Eye Center building to the programmatic support needed to keep vision research programs strong, he says.

“We have truly outstanding people here. We need them to achieve our goals in terms of research to find cures for the eye diseases that so many of us face.”

“It is a wonderful time to be alive,” says Mr. Thompson, who along with his wife, Ellen, supports medical research and other health care efforts. “We see so many dramatic breakthroughs in health care today.” Those breakthroughs take years of scientific investigation, so creating the best possible environment in which such work can take place is important to progress, he believes. And the expansion of the Kellogg Eye Center fits that bill. “We are hopeful for many more great breakthroughs,” Mr. Thompson says.

“And we are just happy to be able to help.”

Making a significant contribution to the expansion campaign and supporting age-related macular degeneration research at Kellogg come naturally to the Thompsons, who became philanthropists when Mr. Thompson sold the asphalt paving business he founded, gave his employees a generous share of the proceeds, and pledged to give much of the remainder away.

The Thompsons have supported cardiology research at the University of Michigan and created the Ellen Thompson Women’s Health Center at St. Joseph Mercy Hospital, among many other endeavors.

2007 annual Report

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Thanking Our Donors Who Have Made Gifts this year

Annual Gifts Given with Gratitude

M

aintaining her sight means the world to Ruth F. Clarke, a retired human resources administrator who has experienced vision problems since she was a child.

“At 91 years old, I am lucky that I have been able to keep my vision so that I can continue to take care of myself,” she says. “Eye disease runs in my family; my mother was nearly blind when she passed away and she had many difficulties.”

The strength of Mrs. Clarke’s resolve and the skill of her ophthalmologists have brought her through three cornea transplants and many years of treatment for glaucoma. “I have been coming to Kellogg since 1991, and I have a great deal of respect for my doctors,” she says.

Mrs. Clarke has been making gifts to the Kellogg Eye Center Annual Fund to support research since she became a patient, increasing her support over time. She has also participated in a clinical trial for a new surgical technique, and she plans to donate her eyes for research.

“Kellogg has been making such strides in research that I am happy to do what I can,” she says. “This is the only way I can repay all of the people who have helped me over the years.”

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$1 million and up Anonymous Donor The Thompson Foundation

$500,000 to $999,999 Lynn H. and Robert W. Browne, DDS ✦

$100,000 to $499,999 Dryer Charitable Foundation ✦ Richard and Jane Manoogian Foundation ✦ Larry G. Miller ✦

$50,000 to $99,999 Anonymous Donor Brian P. Campbell Irene Christopher Bartley and Cheryl Frueh ✧ Mary Jane McMillan Estate Elizabeth M. Potter Estate Virginia and Robert G. Vallee, Sr. Wayne and Joan Webber Foundation ✦ Mary June Wilkinson ✧

10,000 to 49,999 Anonymous Donors ~ 2 Dave and Yvette Bing ✦ Robert and Cassandra Estes ✧✦ Robert and Megan Fante ✧ Douglas and Shelley Felt ✧✦ Mrs. Helen A. Freedman Richard and Lisa Garfinkel ✧✦ Charles and Rita Gelman ✦ Mr. and Mrs. Mudieddine Ghandour Rudy Ghandour James and Charlene Glerum Kathy Holmes Marwan Jaroudi W.R. Kenley Susan Lane Michael and Patricia Levine Carolyn and Paul Lichter ✧✦ Keith and Della McKenzie ✧✦ Vincent and Joyce McLean ✦ Joel and Susan Mindel ✧ John and Phyllis Napley James and Nancy Ravin ✧✦ Roberta W. Siegel Timothy and Laurie G. Wadhams ✦

$5,000 to $9,999 Herbert and Carol Amster ✦ Michael Bisson Eleanor L. Brownell Keith D. Carter ✧

university of michigan kellogg eye center

Scott M. Corin ✧ Ralph and Kay Crew ✧ Dow Chemical Company Foundation Emeline Falls ✧ Joe and Beth Fitzsimmons Barry P. and Mary Ann Hoffman Helen and Richard Kerr ✦ Seymour and Betty Lichter Kim A. Lindenmuth and Matthew Bueche ✧ Michael Petersen and Elizabeth Binasio ✧✦ Jean E. Simpson Estate Alan and Gail Sugar ✧✦ Margaret Vezina Alfred and Carol Wick ✧ W. Scott and Jill Wilkinson ✧ Ellen B. Wiss

$1,000 to $4,999 Tony and Mary Adamis ✧ James and Kathyrn Adams ✧✦ Everton and Saundrett Arrindell ✧✦ Anne and Terry J. Bergstrom ✧ Robert and Jennie Biggs ✧ ✦ Gary and Gretchen Binegar ✧ ✦ Fred and Miriam Blum, Jr. ✧✦ Henry A. Boldt, Jr. ✧ Jason M. Burgett ✧ Mark and Judith Cohen ✧ James and Martha Conrad ✧ Morton S. Cox, Jr. ✧ Jean E. Craig William and Gloria Dean Kristen and Monte Del Monte ✧ Dorothy B. Dickens Estate Deborah M. Eadie ✧ Thomas and Susan Essman ✧ Francis Falck ✧ Ralph M. Fox ✧ Larry and Mary Gerbens ✧ Joanne R. Gradowski Daniel and Norma Green ✧ Robert S. Grosserode ✧ Richard F. Gutow ✧ Andrew and Margaret Hanzlik ✧ Hugh G. Harness Naomi and Theodore Harrison Robert and Carolyn Hoffman ✧ Bret and Laura Hughes ✧✦ Robert and Joan Hughes ✦ Walter and Barbara Hungerford David and Patricia Johnson ✧ Virjean Johnson ✧ Keith Andrew Kobet ✧ William W. Love Dr. and Mrs. Marvin J. Lubeck ✧ James Albert Maraldo

annual Honor Roll of Donors Donald and Jacqueline McCulloch Marvin and Beverly McKenney ✧ Roger Meyer and Judy Gordon ✧ Corey A. Miller ✧ Sayoko Moroi and Michael Fetters ✧ Kenneth H. and Patricia Musson ✧ Bruce L. and Roberta Oliver P & G Fund Michael A. Pachtman ✧ Pfizer Foundation Mark and Kimberly Phelan ✧ Scott M. Pinter, M.D. ✧ Michael and Debra Raizman ✧ Venkat and Alvira Reddy ✧ Daniel Rieders Richard Rodman and Patrice Bouzan-Rodman ✧ Robert J. Roosenberg ✧ Gary S. Sandall ✧ Franklin and Marilyn Sassaman ✧✦ Perry and Faith Schechtman ✧✦ Alan S. and Sandra Schwartz Charles and Kathleen Smith ✧ Michael and Linda Smith-Wheelock ✧✦ H. Kaz Soong and Barbara Nevins-Soong ✧✦ Susan and David Thoms ✧ Triford Foundation Gerald M. Trocchio Peter and Adele Vaculik Genevieve E. Walinski Danny and Yili Liu Wang ✧ Ronald Warwar ✧ Richard and Kay Watnick ✧ George C. Whitaker ✧ Marina V. N. Whitman Martha M. Wright ✧ Fuxiang Zhang ✧

$500 to $999 Gerald and Gloria Abrams Steven and Carol Archer ✧ Roger D. Arnett Ivan A. Baumwell ✧ Steven and Constance Benz ✧ Frederick and Jean Birkhill Edward and Martha Boggs Thomas W. Breakey William and Julie Bromley ✧✦ Christina A. Bruno ✧ Christine R. Buse Richard Carlin ✧ John N. Cassella Hideki Chuman ✧ Ruth F. Clarke Theresa M. Cooney ✧ The Cornblath Family ✧✦ Louise W. DeMartin

Gayle D. Dickerson ✧ Arvene Dickstein John McGregor Dodds Daniel B. Drysdale ✧ John S. Dunn John N. Fetters Philip Gage and Wendy Rampson-Gage ✧✦ Dasa and Nalini Gangadhar ✧✦ Henry E. Gray Froncie A. Gutman ✧ Mr. Kenneth A. Haller John and Joyce Henderson ✧ Millicent Higgins Mary S. Homlar Estate Grand Encampment of Michigan I.O.O.F. James A. Johnson Mark and Linda Johnson ✧✦ Reid and Donna Johnson Judy M. Judd C. Byron Landis ✧ Jean E. Lewis Richard Alan Lewis and Patricia N. Lewis ✧ Eli Lilly & Company Foundation Terrence and Joyce McCool Harry McGee ✧ Medstat Group, Inc. Donald C. Meitz Elaine J. Mickelson Betsy and Kenneth Nisbet ✧✦ Patrick J. Parden ✧ John Wallace Risk Paul Rizzo Earl and Helen Schaper Warren and Nancy Scherer ✧ Kathleen A. Silverman E.H. Newel and Rosemary Smith ✧ Peter K. Speert ✧ Richard and Joyce Toner ✦ James F. Vander ✧ Thomas G. Varbedian ✧

$100 to $499 Anonymous Donors ~ 10 Krista and Bryon Anderson Ann Arbor Benefit Administrators, Inc. J. Gregg Arbaugh Charles R. Ashcraft Phillip and Karen Augustyn ✧ Betty Jean Baier ✦ Dean and Marilyn Baker Sandra L. Baker I. Josephine Ballert Lawrence A. Barnes Philip Barrons Donald F. Baty, Jr. Roy W. Beck ✧

2007 annual Report

Mike Bergiel ✧✦ Roger M. Berkowitz Lana L. Berry Thomas A. Bersani ✧✦ Mary Lee Beuerle ✦ Robert C. Binder Renee Blosser ✧✦ Steven and Jacqueline Boskovich ✧ Nancy S. Boutell James T. Bowen Marcia J. Boynton ✧ Daniel L. Braden Nancy M. Briggs Darcy E. Brink Margaret C. Brown ✦ Geraldine A. Burns Irving F. Burton Donald V. Calamia Timothy N. Carter Claudette J. Casello James W. Cavett James A. Chaffers Roger B. Chard Anne M. Chase Joan M. Christy Donald L. Cole Ritchie L. Coleman Beverly A. Conkle ✧✦ Carl L. Constant ✦ Patrick J. Coppens Ellen L. Coulthard Deborah M. Cox ✧✦ MargaretAnn Cross ✧✦ Speers M. Crumrine Custom Technical Service, Inc. William and Carol Cutler ✧ Dorothy M. Damon Damon’s Grill James E. Davies Delta Gamma Foundation James R. Devine Norma Diamond Mary Ann Doneth Gregory and Dottie Dootz ✧✦ Kenneth R. Dornbrook Alice Engibous Norbert B. Enzer Elsie Enzmann Wendy Erasmous Bita Esmaeli-Gutstein ✧ Hal and Donna Estry Michael J. Fanola Barbara Fazio M. J. Feener Jerome and Polly Finkelstein ✧ Christine Fornal

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annual Honor Roll of Donors

Alum Wants to Carry on Tradition

A

sense of pride and loyalty inspires Douglas P. Felt, M.D., and his wife, Shelley, to give to the Kellogg Eye Center.

“The University of Michigan represents the best in ophthalmology not only in this country, but worldwide,” says Dr. Felt, who completed his residency in the Department in 1983 and a fellowship in oculoplastics in 1984. “I’m proud to have been a part of it, and feel an obligation to help that tradition continue for others.”

After years of private practice in Utah, Dr. Felt still relies on lessons learned during his training, he says.

“The way I practice today is the way I was taught back then. My instructors and mentors always put a strong focus on making sure the patient’s needs were met and that they were getting the best possible outcome they could have.”

To benefit the Eye Center and its tradition of excellence, the Felts support the Alumni Annual Fund and the Kellogg Eye Center expansion campaign, making gifts through their family foundation. “Kellogg scientists are doing some great research, and I hope the expansion will help facilitate even more of that,” Dr. Felt says.

34

Forsythe, Vandenberg, Judge,

Hamilton & Schroer PLLC Nancy C. Francis Bruce and Susan Furr ✧ Margaret E. Gallup Susan A. Gelman General Motors Foundation Edward and Carol George ✧✦ Chad and Courtney Godfrey ✧✦ Liela H. Goldman Gordon Food Service, Inc. Norman E. Grigsby Kathleen D. Haack Margaret H. Hagen Jane Hakken William P. Haney ✧ Charlotte Hanson J. Ken Harkleroad Laurelynne D. Harris John E. Held Frederick J. Heyner ✧ Jane G. Hiss Larry Hiss Peter and Karla Hitchcock ✧✦ Charles F. Hoitash Janet Woods Hoobler John E. Hoshaw Christy Bole Hughes Margaret M. Hughes Larry J. Hunt Bernice Hyne Kenneth and Betty Johnson Mark E. Johnston ✧ Betty Brown Jones Mark E. Jones James D. Jorgensen Andree Joyaux George H. Jury Daniel B. Kachnowski Irving Henry Kananen ✦ Athanasios J. Karoukis ✧ Rosemary S. Kaye Kellogg’s Corporate Citizenship Fund Michael A. Kipp ✧ Mary Jo Knight Piyush and Sarla Kothary ✧ Mrs. Harry Krashen Norman N. Krieger ✦ Susan Krucki Dorothy Kurtz Louis H. Landau Marie Lane Louis H. LaRiche Gloria A. Lehman Cheryl L. Lemieux Jeanne M. Lerchen

Erika M. Levin ✧ Myron Levine Sherry L. Lindahl Auburn Area Lions Club Huron Valley Sunrise Lions Club Thomas J. Long Helen Price Luckham Susan Ludwig ✧✦ Doris I. MacDonald Joseph L. Maggini Make Metal Recycling Edna F. Manns Gregory Mazurak Stephen A. Mazurak Lincoln H. McGhee Ning McLaren ✧ Donna Rita McNally ✦ Brian L. McPherson Herbert R. Metzger William M. Mikkelsen Lorraine M. Miller Helen L. Mitchell Donald J. Mitrzyk Marlene M. Moleski Jock Morrison ✧ John D. Mott Joseph L. Mottillo H. Christian Mueller Alphonsus C. Murphy Dave and Jan Musch ✧ Neil/Carter, LLC Olga Nelson Jonathon P. Niemczak Kenneth E. Oettle John Orr Kathryn R. Osterholzer Dr. and Mrs. Mohammad Othman ✧✦ Lavona M. Pakko Carol M. Paull ✦ Joseph Pavka Margaret Pennington ✧ Keith H. Perkins ✦ Maureen Margaret Phelps Douglas and Sheryl Podlewski ✧✦ Diana L. Prittinen Donald and Debra Puro ✧ Eric R. Ray Robert Ogden Reisig ✧ Charles S. Remenar Robert Reske Debra and Graham Rethgrew Mrs. Elizabeth B. Roberts Arthur C. Rocco Carl D. Roe Paula J. Ross Rennie and Michael Roth ✧

university of michigan kellogg eye center

annual Honor Roll of Donors Jonathan A. Rowe ✦ Loretta D. Sammet Dorothy Schaefer Wilford Schaldenbrand Leonard T. Schmidt Virginia M. Schueler John C. Schultz Cindy Shaffran Elvera B. Shappirio Lorraine M. Sheppard Melvin A. Simon Pauline Skinner ✦ Alene M. Smith Camille S. Smith ✧✦ Kenneth S. Smith Sue-Ellen Smith Erling B. Snorrason Carol L. Standardi ✧✦ Amy Steele ✧✦ Thomas and Jane Stratford ✧ James P. Symons Scott Szalay ✧ ✦ F. Brian Talbot Terry Wayne Talley ✧ Mrs. David Moses Tear ✦ John H. Tedford ✧ Edward Tenner ✧ Roger C. Thibault Karen Burkett Thomas James B. Thompson C. Wayne Tiller Mr. and Mrs. John Tongusi ✧✦ G. Bruce Van Dam Bram VanLeer Frank Veres Claudia M. Wagner David R. Wagner A. Phyllis Wallace Randall S. and William K. Wallach ✧ Melissa K. Warner John W. Weigel II Linda S. Weimer William W. Wells Robert Werthman Molly and Robert Wheaton ✧ Avis L. White Margaret B. White ✧✦ Richard C. Wilson Marion T. Wirick Nancy J. Wood Wen-Jei Yang Richard A. Yarmain Juliana Young Harry and Miriam Yukelson Dorothy A. Zelisse Jeffrey M. Zink ✧

W. Tom ZurSchmiede, Jr.

UP TO $100 Anonymous Donors ~ 23 William Achterberg Katherine M. Adams Ronald J. Agin Shirley J. Alders Christopher J. Allan Brian L. Altevogt Patricia A. Anderson Greg Atkins Katherine Augustaitis ✧ Rochelle R. Balkam Laurel A. Barnes Ruth S. Beardsley Forest Beauregard Harry E. Beeson Eleanor Beitelshus Margaret Bembenek Peggy A. Bennett Paul E. Benson Lois Bereza Minnie Berki Samir and Mona Binno Debra Bolton Ronald J. Bonis Donna L. Book Allison and Michael Borha Judith M. Boulter Joyce M. Braun Karen L. Brennan Candiss E. Brewer Daniel J. Brieschke Brian P. Brooks ✧ La Vern E. Brown Vida Brucker Marjorie B. Bryen Alice G. Bull Roger Burg Lisa Burkhart and Frank Hunt ✧ David Busack John F. Buss Barbara R. Caird Audrey H. Campbell Terri L. Campbell-Smith Nancy and Robert Capilla Thomas L. Capua, Sr. Carola Caroselli Nancy Ann Carpenter Albert Chambers L. Ross Chambers Emery and Martha Chandler William Chandler Jane H. Chapelle Ralphine Chilla

2007 annual Report

Marvin Church Marilyn A. Cieslik Tomasina Cingolani Carolyn J. Clark John T. Clarke George Clausen ✦ Shirley A. CoeBeck ✧ Alice S. Cohen Clare R. Coles Girture Coon Frank and Birdie Cooper Judy J. Coppola Mario J. Cortese Cecilia V. Cosby Ellen L. Coulthard George J. Courey Robert W. Cox James F. Cronenwett Wanda Cronenwett Janis E. Currey Barbara Currier Susan M. Dancer Cynthia S. Danforth Dolores D. Daudt Ronda F. Daugherty Beverly Deal Karen B. Delong Catherine Derezinski Colleen Devlin Helen A. De Wolfe Donald A. Dodick Michael G. Doran Dow Corning Corporation Lillian G. Drury John E. Dubnicka Donald E. Dufek Donna Duffy ✧✦ Sandra and Eric Dunkel Betty C. Dupont Geraldine K. Dupont Robert E. Ehle Vincent J. Eible, Jr. Susan L. Englehart Charles D. Erickson Ervin Industries Sabrina M. Ervin Margaret Ettlich Kathleen G. Eubank Marilyn R. Ewing Beth Farrell Nancy A. Fay Anthony A. Fennell Bob Ferris Petro Ficaj Elena Filippova ✧✦ Arthur T. Fine

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annual Honor Roll of Donors

Bequest Benefits Research

W

anting to reward organizations that work to benefit others, Elizabeth M. Potter left the majority of her estate to charities when she passed away last year.

Mrs. Potter had undergone eye surgeries, yet remained an avid reader. “She was aware of the good works of the Kellogg Eye Center,” explains Chester C. Lawrence, Mrs. Potter’s attorney.

She made a generous bequest to agerelated macular degeneration research at Kellogg, where scientists are studying the multi-faceted disease from many angles.

Born in 1911, Mrs. Potter worked for years as a legal secretary. She moved from Birmingham, Michigan, to the Detroit area for her retirement, spending time at the Oakwood Common Retirement Community in Dearborn.

“She was a very kind and giving lady,” Mr. Lawrence says.

36

Rosalind Fuertes Fink Lucile E. Finkbeiner Fred Fleischer Kimberly Foerster Suzanne Foster Anthony A. Foust Eugene J. Frausto Mildred C. Fullam Carl A. Gabrielson William T. Galvin Helen Kay Garcia Betty J. Garner Mary R. Gergel Jacqueline C. Gilbert Jesse E. Gordon Waleed K. Gosaynie M.J. Grabowski Irene Joan Grant Amy C. Grier Chester J. Grifka David Grossman Amber M. Hackett Donald and Shirley Haddix Michio Peter Hagiwara Sandra K. Hale Dr. Edward and Mrs. Patricia Hall ✧ Heather Hallet Joyce A. Ham Margaret Harburn Paul Hardman Julia F. Harris Unabelle Harris James E. Hart Harriet Hartman Nancy Hartman Jerome P. Hartweg Eva J. Hayes Donna Heckathorn Donna Hepner Steven Hepner Harriet M. Heppinstall Ruth Heyn Harold E. Hicks Judith Dukesherer Hill Richard W. Hill Shirley Mirsky Hogan Don E. Horning David C. Horton Robert E. Hosbach Karen T. Hubbard ✦ Randal R. Huber Donna Huffman David P. Ingram Hilegard Jahnke Lori Jamison Linda C. Jeffries Raymond L. Jenks Audrey L. Jeschke Lisa Johnson

Irene Jones Mark Gregory Jones Lucille T. Jurson Laura E. Kakuk-Atkins ✧ Fannie Kambas Brenda L. Kapp Michael R. Kasischke Leah Kasper Jill Taft Kaufman Andrew Kay Charlene M. Kay Erlene M. Keeler Nancy Kelly Jeff R. Kennedy Geraldine Keon Roberta C. Kerste Mike Kestly Laverne Klawitter Charles A. Kleinschmidt Thaddeus F. Klos Jeffry R. Knez Adabelle Knief Stephen A. Kollath Wilma B. Koski Ann Marie Kotre J. David Kotre Sandra A. Laginess John G. Lapp Robert F. Lavens Beatrice D. Lawrence Lucille Lefler Linda S. Leslie Robertson A. Lewis Susan Lichter Thomas Clark Lillie Michael and Judy Lipson ✧ Miriam Long Thomas J. Longworth Michael W. Loviska Ruth Lum Jane M. Macksood Bruce C. Maddock Mary A. Marsh Larry K. Martin Mariann K. Martin Lino Martinez Elizabeth Martins Patricia M. Martorelli Shannon K. Marz Cynthia F. Mast Marguerite Maupin Frances A. Maycroft ✦ Edith A. Maynard Bonnie McDaniel Wilbert J. McKeachie Sean T. McLaughlin Clement McLouth Catherine McNair Sharon L. McNutt

university of michigan kellogg eye center

annual Honor Roll of Donors Brian L. McPherson John R. McWilliams ✧ Lila A. McMechan Hubert J. Meier Walter Meiers Pluma M. Melville Sue I. Mershon Fredrick W. Metzger Ruth E. Michaelis William Michaluk Dino Milazzo Kirsten R. Moline Gloria A. Monaghan Margaret M. Monforton Steve Monk Clare E. Monroe James I. Morgan Mothers Day Care Joanne E. Mueller David and Benita Murrel ✧ George W. Myers Ajay S. Natarajan Dorothy C. Natchez Louis E. Nault Marjory J. Nautsch Dianne M. Neihengen Douglas F. Nelson Gordon A. and Vernie Nethercut Harry Nistel Steve Nordberg Kathryn L. Oakley Cynthia M. O’Connell Nancy Lynne O’Connor Richard A. Olson Gale and Yehuda Oren ✧✦ Steve J. Orto Luetta Osborne Pearl E. Osburn Constance L. Osler Dawn R. Pankopf Sidney Parker Lynne Pavesi Hemant Pawar ✧✦ Donald C. Peterson Marshall E. Peterson Carol M. Petros Raymond A. Pinkham ✧ Barbara and David Plants Farrell D. Plotner Linda M. Podojil Norma E. Poet Carol J. Pollack-Rundle and Family ✧✦ Wallace G. Prince Kenneth H. Pritchard Carrie Quakenbush John H. Reding Thomas W. Reed Christopher D. Reid Clark Richardson

Robert L. Richardson, Jr. Patricia Dill Rinvelt Ruth A. Roffey Gary W. Rosteck Clifton D. Rowland Frank Rozsa and Szonja Puskas-Rozsa ✧✦ James C. Rucker Peter N. Ruma, Sr. Frances M. Runciman Walt Rundles ✧ Timothy W. Runstadler Stephanie Ryalls Joseph R. Rzepecki Joe Salmonowicz, Jr. Mr. Ross and Mrs. Shannan Saltz ✧✦ Charles L. Schaldenbrand Max F. Schiebold Tara Schmitt and Chris Palumbo ✧ Deborah A. Schmitz Clarence W. Schneider Judith A. Schneider Mary J. Schulte Mira S. Schultz George Schwartz Shirley J. Segadi Ruth I. Segura David J. Seibert Raymond V. Sessa Carolyn J. Seymour Mary L. Shannon Kathyleen R. Shawen Fred L. Shockley, Jr. Roni and Max Shtein ✧ Susan and Gary Simpson ✧ May Niemira Sisson David M. Smith ✧ Jeanne F. Smith ✧✦ Norma A. Smith Susan Smith-Brooks Judith R. Smutek Barbara A. Snow Dorothy L. Sowinski Burt D. Spafford Ruth Sparks Joyce Spears Ronald and Gloria Spitler Gordon W. Squires Linda J. Squires William H. Squires Edith L. Stockwell Evelyn M. Strieter Sharyn A. Sturt Bessie Sweet Marcin M. Szuberla Douglas B. Taylor Helen M. Taylor Kenneth F. Thomas, Jr. Elaine J. Thompson R. Jean and Doug Thrams

2007 annual Report

Karen J. Tousignant Priscilla Tse Lois Faber Tuinenga Darcy L. Turner Shelly Turner Charlotte M. Van Der Bos Henry A. Vander Kaay Morris J. VanHouten Michelle L. Van Valkenburg Joyce A. Vershum Ladies Auxiliary VFW James Viers Lucy Ann Visovatti Elora J. Vogel Maryann Wakefield Edward T. Wall ✧ Charlotte A. Walls Robinson Sidney Warschausky Mary E. Wehking Renee M. Weidmayer Carolyn Jean Weigle Amy Weir Alyce Whipp ✧ David B. White Debbie L. White Lois R. White Ronald M. Wicinski Joseph J. Wiggins Trudy Wilder The Wilkinson Family Mary Laux Williams Kenneth and Lois Williams Bruce J. Wilson Robert A. Wilson William R. Wilson Kim Wisniewski ✧ Joanne C. Witherspoon Lynn Witmer ✦ Miss Charlotte A. Wolfe Ford L. Wright Richard Mayo Wycoff Judith and Roger Wynsma Kenneth W. and Melissa H. Zaletski Allan C. Zander Carol K. Ziegler Jennifer Ziehm-Scott ✧✦ George J. Zissis Josephine Zullo

✧ Faculty, staff, and alumni donors ✦ Multi-year campaign pledges Gifts received from July 1, 2006 through June 30, 2007 We make every effort to ensure the honor roll is as accurate as possible.

Please let us know if you note any errors.

37

Faculty Honors, Recognition, and Publications

Steven M. Archer, M.D. Awards/Honors/Leadership • Best Doctors in America • Election to active membership, American Ophthalmological Society Publications Eisengart J, Goings L, Prusak R, Hackel R, Archer S, Moroi SE. Surgical management of unilateral glaucoma associated with Poland sequence. Arch Ophthalmol 2006;124:1206-7.

Eibschitz-Tsimoni M, Tsimoni O, Archer SM, Del Monte MA. Discrepancies between intraocular lens implant power prediction formulas in pediatric patients. Ophthalmology 2007;114:383-6.

Mandal MN, Vasireddy V, Reddy GB, Wang X, Moroi SE, Pattnaik BR, Hughes BA, Heckenlively JR, Hitchcock PF, Jablonski MM, Ayyagari R. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 2006;47:5505-13.

Mandal MN, Vasireddy V, Jablonski MM, Wang X, Heckenlively JR, Hughes BA, Reddy GB, Ayyagari R. Spatial and temporal expression of MFRP and its interaction with CTRP5. Invest Ophthalmol Vis Sci 2006;47:5514-21.

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. Surv Ophthalmol 2007 [in press].

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens implant power prediction formulas in pediatric patients. J AAPOS 2007 [in press].

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA, Furr BA. Current concepts in the management of concomitant exodeviations. Comp Ophthalmol Update 2007 [in press].

Radha Ayyagari, Ph.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Scientific Advisory Board Member, Foundation Fighting Blindness • Reviewer, Foundation Fighting Blindness • Member, National Ophthalmic Disease Genotyping Network (eyeGene), NEI • Member, Steering Committee, Center for Human Genetics in Health and Medicine, University of Michigan

Iannaccone A, Mura M, Dyka FM, Ciccarelli ML, Yashar BM, Ayyagari R, Jablonski MM, Molday RS. An unusual X-linked retinoschisis phenotype and biochemical characterization of the W112C RS1 mutation. Vision Res 2006;46:3845-52.

Vasireddy V, Uchida Y, Salem N, Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, Dlugosz A, Elias PM, Holleran WM, Ayyagari R. Loss of functional ELOVL4 depletes very long-chain fatty acids (>=C28) and the unique {omega}O-acylceramides in skin leading to neonatal death. Hum Mol Genet 2007;16:471-82.

Downs K, Zacks DN, Caruso R, Karoukis AJ, Branham K, Yashar BM, Haimann MH, Trzupek K, Meltzer M, Blain D, Richards JE, Weleber RG, Heckenlively JR, Sieving PA, Ayyagari R. Molecular testing for hereditary retinal disease as part of clinical care. Arch Ophthalmol 2007;125:252-8.

Yzer S, Zonneveld M, Lopez I, Ayyagari R, Teye-Botchway L, van den Born LI, MotaVieira L, Cremers FPM, Koenekoop RK. Phenotypic and molecular analysis of a family with three sibs affected by severe autosomal recessive retinitis pigmentosa and a second cousin affected by Stargardt macular dystrophy. Mol Vision 2007 [in press].

Publications Raz-Prag D, Ayyagari R, Fariss RN, Mandal MN, Vasireddy V, Majchrzak S, Webber AL, Bush RA, Salem N Jr, Petrukhin K, Sieving PA. Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease. Invest Ophthalmol Vis Sci 2006;47:3603-11.

Mandal MN, Ayyagari R. Complement factor H: spatial and temporal expression and localization in the eye. Invest Ophthalmol Vis Sci 2006;47:4091-7.

38

Vasireddy V, Jablonski MM, Mandal MN, Raz-Prag D, Wang XF, Nizol L, Iannaccone A, Musch DC, Bush RA, Salem N Jr, Sieving PA, Ayyagari R. Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. Invest Ophthalmol Vis Sci 2006;47:4558-68.

Terry J. Bergstrom, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership Professor Emeritus, University of Michigan Faculty Advisor, Galens Medical Society, University of Michigan

university of michigan kellogg eye center

Outreach Glaucoma screenings in local communities throughout the year

Christina A. Bruno, M.D. Publications Bruno CA, Moroi SE. Plateau iris and acute closed-angle glaucoma following retinal detachment repair. Glaucoma Today 2006 (July-August):37-9.

Bruno CA, Fisher G, Moroi SE. Is “scarless wound healing” applicable to glaucoma surgery? Expert Rev Ophthalmol 2007;2:79-90.

Theresa M. Cooney, M.D. Awards/Honors/Leadership Michigan Society of Eye Physicians and Surgeons, delegate to the Michigan State Medical Society Publications Lelli GJ, Musch DC, Gupta A, Farjo QA, Nairus TM, Mian SI. Ophthalmic cyclosporine use in ocular graft-versus-host disease.

Cornea 2006;25:635-8.

Mian S, Nairus TM, Sugar A. Femtosecond laser-assisted LASIK. In: Vajpayee R, ed.

Step by Step LASIK Surgery. London:Martin Dunitz UK/Taylor & Francis; 2006.

Cooney TM, Johnson CS, Elner VM. Keratomalacia due to psychiatric-induced dietary restrictions. Cornea 2007 [in press].

Wayne T. Cornblath, M.D. Awards/Honors/Leadership • Best Doctors in America • Co-Director, Walsh in Asia Symposium, International Neuroophthalmology Society, Tokyo, Japan, 2006 • Director, Top Ten Neuro-Ophthalmic Diagnoses You Can’t Afford to Miss; American Academy of Neurology, 2007 • Director, Now You See It, Now You Know It, Pathognomonic Neuro-Ophthalmology Findings, American Academy of Neurology, 2007 • Director, Top Ten Neuro-Ophthalmic Diagnoses You Can’t Afford to Miss; Indian Health Service Biennial Eye Care Conference 2006 • Director, Now You See It, Now You Know It, Pathognomonic Neuro-Ophthalmology Findings, Indian Health Service Biennial Eye Care Conference, 2006

Faculty Honors, Recognition, and Publications

Publications Parikh M, Miller NR, Lee AG, Savino PJ , Vacarezza MN, Cornblath WT, Eggenberger E, Antonio-Santos A, Golnik K, Kardon R, Wall M. Prevalence of a normal C-reactive protein with an elevated erythrocyte sedimentation rate in biopsy-proven giant cell arteritis.

Ophthalmology 2006;113:1842-5.

Cornblath WT. Optic nerve glioma. Practical Ophthalmol Monographs 2007 [in press].

Cornblath WT. Optic nerve sheath meningioma. Practical Ophthalmol Monographs 2007 [in press].

Monte A. Del Monte, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Vice Chairman, International Affairs Committee, American Association for Pediatric Ophthalmology and Strabismus • Special Invited Guest Speaker, Asia Pacific Association of Ophthalmology 21st Annual Meeting, Singapore Outreach • Visiting Professor and Mentor, ORBIS, San Jose, Costa Rica • Special Guest Lecturer, World Eye Mission, Guatemala City, Guatemala Publications Del Monte M, Hertle R. Extraocular muscle surgery for nystagmus. J Pediatr Ophthalmol Strabismus 2006;43(4):200-4.

Eibschitz-Tsimhoni M, Tsimhoni O, Archer SM, Del Monte MA. Discrepancies between intraocular lens implant power prediction formulas in pediatric patients. Ophthalmology 2007;114:383-6.

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. Surv Ophthalmol 2007 [in press].

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens implant power prediction formulas in pediatric patients. J AAPOS 2007 [in press].

Publications Beaudoin DL, Borghuis BG, Demb JB. Cellular basis for contrast gain control over the receptive field center of mammalian retinal ganglion cells. J Neurosci 2007;27:2636-45.

Zaghloul KA, Manookin MB, Borghuis, BG, Boahen K, Demb JB. Functional circuitry for peripheral suppression in mammalian Y-type retinal ganglion cells. J Neurophysiol 2007 [in press].

Maya Eibschitz, M.D. Grants see grants, pages 48-51 Publications Eibschitz-Tsimhoni M, Tsimhoni O, Archer SM, Del Monte MA. Discrepancies between intraocular lens implant power prediction formulas in pediatric patients. Ophthalmology 2007;114:383-6.

Repka MX, Melia M, Eibschitz-Tsimhoni M, London R, Magoon E. The effect on refractive error of unilateral atropine as compared with patching for the treatment of amblyopia.

J AAPOS 2007;11:300-2.

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. Surv Ophthalmol 2007 [in press].

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens implant power prediction formulas in pediatric patients. J AAPOS 2007 [in press].

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA, Furr BA. Current concepts in the management of concomitant exodeviations. Comp Ophthalmol Update 2007 [in press].

Susan G. Elner, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Thesis Review Committee, American Ophthalmological Society • Ad hoc member, Neurobiology C, Veterans Affairs Merit Review Committee

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA, Furr BA. Current concepts in the management of concomitant exodeviations. Comp Ophthalmol Update 2007 [in press].

Publications Aizman A, Johnson MW, Elner SG. Treatment of acute retinal necrosis syndrome with oral antiviral medications. Ophthalmology 2007;114:307-12.

Jonathan B. Demb, Ph.D.

Bian Z-M, Elner SG, Elner VM. Regulation of VEGF mRNA expression and protein secretion by TGFb2 in human retinal pigment epithelial cells. Exp Eye Res 2007;34:812-22.

Grants see grants, pages 48-51

2007 annual Report

Elner VM, Demirci H, Morton AD, Elner SG, Hassan AS. Transcaruncular medial canthal ligament plication for repair of lower eyelid malposition. Arch Ophthal 2007;125:374-9.

Ronan SM, Yoganathan P, Chien F, Corcostegui IA, Blumenkranz MS, Deramo VA, Elner SG, Fastenberg DA, Johnson MW, Lopez M, Mateo C, Moshfeghi DM, Navarro R, Rosenblatt BJ, Sanislo SR, Saxe SJ, Zacks DN. Retinal pigment epithelium tears after intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina 2007;27:535-40.

Demirci H, Hassan AS, Elner SG, Boehlke C, Elner VM. Comprehensive combined anterior and transcaruncular orbital approach to medial canthal ligament plication. Ophthal Plast Reconstr Surg 2007 [in press].

Bian Z-M, Elner SG, Elner VM. Thrombininduced VEGF expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2007;48:2738-46.

Victor M. Elner, M.D., Ph.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Board of Directors, American Association of Ophthalmic Pathologists • Elected to Verhoeff-Zimmerman Society • First place, Ann Arbor SPARK Entrepreneur awards • Featured Speaker, Canadian Ophthalmological Society • Visiting Professor, Canadian Ophthalmic Pathology Society • Member, International Thyroid Eye Disease Study Group • Reviewer, study sections: SBIR (NEI), Sjogren’s Syndrome (NIDCR), Study Section C (NEI) Publications Elner VM, Demirci H, Nerad J, Hassan AS. Periocular necrotizing fasciitis: mechanisms of disease for visual morbidity and treatment.

Ophthalmology 2006;113:2338-45.

Demirci H, Hassan AS, Reck SD, Frueh BR, Elner VM. Graded full-thickness anterior blepharotomy for correction of upper eyelid retraction not associated with thyroid eye disease. Ophthal Plast Reconstr Surg 2007;23:39-45.

Elner VM, Demirci H, Morton AD, Elner SG, Hassan AS. Transcaruncular medial canthal ligament plication for repair of lower eyelid malposition. Arch Ophthal 2007;125:374-9.

39

Faculty Honors, Recognition, and Publications

Victor Elner, cont’d

Demirci H, Hassan AS, Reck SD, Frueh BR, Elner VM. Graded full-thickness anterior blepharotomy for correction of upper eyelid retraction not associated with thyroid eye disease. Ophthal Plast Reconstr Surg 2007;23:39-45.

Chong DY, Demirci H, Ronan SM, Flint A, Elner VM. Orbital rhabdomyosarcoma in Li-Fraumeni syndrome. Arch Ophthalmol 2007;125:566-9.

Bian Z-M, Elner SG, Elner VM. Regulation of VEGF mRNA expression and protein secretion by TGFb2 in human retinal pigment epithelial cells. Exp Eye Res 2007;34:812-22.

Hidayat AA, Flint A, Marentette L, Torczynski E, Al-Qahtani JM, Ahl NC, Elner VM. Myxomas and angiomyxomas of the orbit: a clinicopathologic study of six cases.

Ophthalmology 2007;114:1012-9.

Boehlke CS, Frueh BR, Flint A, Elner VM. Malignant fibrous histiocytoma of the lateral conjunctiva and anterior orbit. Ophthal Plast Reconstr Surg 2007 [in press].

Frueh WT, Frueh BR. Errors of single-mirror or prism Hertel exophthalmometers and recommendations for minimizing the errors.

Ophthal Plast Reconstr Surg 2007;23:197201.

Fahim DK, Frueh BR, Musch DC, Nelson CC. Complications of pegged and non-pegged hydroxyapatite orbital implants. Ophthal Plast Reconstr Surg 2007;23:206-10.

Boehlke CS, Frueh BR, Flint A, Elner VM. Malignant fibrous histiocytoma of the lateral conjunctiva and anterior orbit. Ophthal Plast Reconstr Surg 2007 [in press].

Bian Z-M, Elner SG, Elner VM. Thrombininduced VEGF expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2007;48:2738-46.

Philip J. Gage, Ph.D. Grants see grants, pages 48-51

Demirci H, Hassan AS, Elner SG, Boehlke C, Elner VM. Comprehensive combined anterior and transcaruncular orbital approach to medial canthal ligament plication. Ophthal Plast Reconstr Surg 2007 [in press].

Publications Asai-Coakwell M, Backhouse C, Casey RJ, Gage PJ, Lehmann OJ. Reduced human and murine corneal thickness in an AxenfeldRieger syndrome subtype. Invest Ophthalmol Vis Sci 2006;47:4905-9.

Cooney T, Johnson CS, Elner VM. Keratomalacia due to psychiatric-induced dietary restrictions. Cornea 2007 [in press].

Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol 2006;296:437-49.

Demirci H, Elner VM. Double bicanalicular silicone intubation for management of partial lacrimal drainage obstruction in adults.

Ophthalmology 2007 [in press].

Demirci H, Elner VM. Soft connective tumors of ocular tissues. In: Klintworth GK, Garner A, Cameron JD, Elner VM, Heathcote JG, Proia AD, Rao NA, (eds). Garner & Klintworth’s Pathobiology of Ocular Disease.

New York: Taylor & Francis 2007 [in press].

Sclafani AM, Skidmore JM, Ramaprakash H, Trumpp A, Gage PJ, Martin DM. NestinCre mediated deletion of Pitx2 in the mouse.

Genesis 2006;44:336-44.

Hassan AS, Elner VM. Optic nerve glioma.

In: Tasman W. and Jaeger EA. (eds). Duane’s Clinical Ophthalmology. Philadelphia: Lippincott, Williams & Wilkins 2007 [in press].

Honore AL, Coulon V, Marcil A, Lebel M, Lafrance-Vanasse J, Gage PJ, Camper S, Drouin J. Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development. Dev Biol 2007 [in press].

Bartley R. Frueh, M.D.

Daniel G. Green, M.D.

Awards/Honors/Leadership • Best Doctors in America

Grants see grants, pages 48-51

Publications Lelli GJ, Jr., Demirci H, Frueh BR. Avulsion of the optic nerve with luxation of the eye after motor vehicle accident. Ophthal Plast Reconstr Surg 2007;23:158-60.

Publications Green DG, Kapousta-Bruneau NV. Evidence that L-AP5 and D,L-AP4 can preferentially block cone signals in the rat retina.

Vis Neurosci 2007;24:9-15.

40

university of michigan kellogg eye center

Richard E. Hackel, C.R.A. Awards/Honors/Leadership • Secretariat Award, American Academy of Ophthalmology, 2006 • Best of Show, Ophthalmic Photographers’ Society, 2006 • Best article in Journal of Ophthalmic Photography, Ophthalmic Photographers’ Society, 2006 • Section editor, “Blink,” Eyenet • Editorial Board, Journal of Ophthalmic Photography • Editorial Board, Eyenet • Editorial Board, Journal of Neuro Ophthalmology • Featured photograph, Map: Right Back at You, Discover April 2007 • Cover photograph, Ophthalmology 2007;14:February Publications Eisengart J, Goings L, Prusak R, Hackel R, Archer S, Moroi SE. Surgical management of unilateral glaucoma associated with Poland sequence. Arch Ophthalmol 2006;124:1206-7.

Hackel RE. Ophthalmic Photography. In: Stein, Stein, Freeman (eds.), The Ophthalmic Assistant, 8th ed. New York: Elsevier 2006, Chap 37.

Huynh TH, Johnson MW, Hackel RE. Bilateral proliferative retinopathy in chronic myelogenous leukemia. Retina 2007;27:124-5.

Huynh TH, Johnson MW, Hackel RE. Subretinal Candida albicans abscesses responsive to oral voriconazole. Retinal Cases and Brief Reports 2007 [in press].

Adam S. Hassan, M.D. Publications Elner VM, Demirci H, Nerad JA, Hassan AS. Periocular necrotizing fasciitis with visual loss pathogenesis and treatment. Ophthalmology 2006;113:2338-45.

Elner VM, Demirci H, Morton AD, Elner SG, Hassan AS. Transcaruncular medial canthal ligament plication for repair of lower eyelid malposition. Arch Ophthal 2007;125:374-9.

Demirci H, Hassan AS, Reck SD, Frueh BR, Elner VM. Graded full-thickness anterior blepharotomy for correction of upper eyelid retraction not associated with thyroid eye disease. Ophthal Plast Reconstr Surg 2007;23:39-45.

Demirci H, Hassan AS, Elner SG, Boehlke C, Elner VM. Comprehensive combined anterior and transcaruncular orbital approach to medial canthal ligament plication. Ophthal Plast Reconstr Surg 2007 [in press].

Faculty Honors, Recognition, and Publications

Hassan AS, Elner VM. Optic nerve glioma.

In: Tasman W. and Jaeger EA. (eds). Duane’s Clinical Ophthalmology. Philadelphia: Lippincott, Williams & Wilkins 2007 [in press].

John R. Heckenlively, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Senior Achievement Award, American Academy of Ophthalmology • Keynote Speaker, Department of Ophthalmology Research Day 2006, University of Alberta Publications Sullivan LS, Bowne SJ, Seaman CR, Blanton SH, Lewis RA, Heckenlively JR, Birch DG, Hughbanks-Wheaton D, Daiger SP. Genomic rearrangements of the PRPF31 gene account for 2.5% of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 2006;47:4579-88.

Chang B, Dacey MS, Hawes NL, Hitchcock PF, Milam AH, Atmaca-Sonmez P, Nusinowitz S, Heckenlively JR. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 2006;47:5017-21.

Mandal MN, Vasireddy V, Reddy GB, Wang X, Moroi SE, Pattnaik BR, Hughes BA, Heckenlively JR, Hitchcock PF, Jablonski MM, Ayyagari R. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 2006;47:5505-13.

Mandal MN, Vasireddy V, Jablonski MM, Wang X, Heckenlively JR, Hughes BA, Reddy GB, Ayyagari R. Spatial and temporal expression of MFRP and its interaction with CTRP5. Invest Ophthalmol Vis Sci 2006;47:5514-21.

Ronan S, Nusinowitz S, Swaroop A, Heckenlively JR. Senile panretinal cone dysfunction in age-related macular degeneration (AMD): a report of 52 AMD patients compared to age-matched controls. Trans Am Ophthalmol Soc 2006;104:232-40.

Nusinowitz S, Ridder WH 3rd, Pang JJ, Chang B, Noorwez SM, Kaushal S, Hauswirth WW, Heckenlively JR. Cortical visual function in the rd12 mouse model of Leber Congenital Amarousis (LCA) after gene replacement therapy to restore retinal function.

Vis Res 2006;46:3926-34.

Friedman JS, Chang B, Kannabiran C, Chakarova C, Singh HP, Jalali S, Hawes NL, Branham K, Othman M, Filippova E, Thompson

DA, Webster AR, Andreasson S, Jacobson SG, Bhattacharya SS, Heckenlively JR, Swaroop A. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration.

Am J Hum Genet 2006;79:1059-70.

Chang B, Hawes NL, Pardue MT, German AM, Hurd RE, Davisson MT, Nusinowitz S, Rengarajan K, Boyd AP, Sidney SS, Phillips MJ, Stewart RE, Chaudhury R, Nickerson JM, Heckenlively JR, Boatright JH. Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene. Vis Res 2007;47:624-33.

Downs K, Zacks DN, Caruso R, Karoukis AJ, Branham K, Yashar BM, Haimann MH, Trzupek K, Meltzer M, Blain D, Richards JE, Weleber RG, Heckenlively JR, Sieving PA, Ayyagari R. Molecular testing for hereditary retinal disease as part of clinical care. Arch Ophthalmol 2007;125:252-8.

Chang B, Hawes NL, Davisson MT, Heckenlively JR. Mouse models of RP. In: Tombran-Tink J, Barnstable CJ, eds. Retinal Degenerations: Biology, Diagnostics, and Therapeutics.

Totowa, NJ:Humana Press, 2007.

Peter F. Hitchcock, Ph.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Invited lecture, Neuroscience Graduate Studies Program and the Department of Neuroscience, Ohio State University • Invited lecture, University of Ottawa Eye Institute, Center for Vision Research • Session organizer, 18th Spring Brain Conference, Sedona, AZ • Director, University of Michigan Interdepartmental Neuroscience Graduate Program • Member, Cell Biology Review Panel, National Institutes of Health • Grant reviewer, The Wellcome Trust, London Publications Chang B, Dacey MS, Hawes ML, Hitchcock PF, Milam AH, Atmaca- Sonmez P, Nusinowitz S, Heckenlively JR. Cone photoreceptor function loss- 3, a novel mouse model of achromatopsia due to a mutation in Gnat2.

Invest Ophthalmol Vis Sci 2006;47:5017-21.

Mandal MNA, Vasireddy V, Reddy GB, Wang XF, Moroi SE, Pattnaik BR, Hughes BA, Heckenlively JR, Hitchcock PF, Sieving PA, Jablonski MM, Ayyagari R. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 2006;47:5505-13.

2007 annual Report

Ochocinska M, Hitchcock PF. Cellular expression of the bHLH transcription factor, neuroD, in the retina of the embryonic and larval zebrafish. J Comp Neurol 2007;501:1-12

Bret A. Hughes, Ph.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Grant reviewer, Fight for Sight • Grant reviewer, Biology and Diseases of the Posterior Eye Study Section, National Eye Institute • Member, Retinopathy Special Emphasis Panel, National Eye Institute • Director, University of Michigan Core Center for Vision Research • Invited talk, National Eye Institute Publications Mandal MNA, Vasireddy V, Reddy GB, Wang X, Moroi SE, Pattnaik BR, Hughes BA, Heckenlively JR, Hitchcock PF, Jablonski MM, Ayyagari R. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 2006;47:5505-13.

Mandal MNA, Vasireddy V, Jablonski, M, Wang XF, Heckenlively JR, Hughes BA, Reddy GB, Ayyagari R. Spatial and temporal expression of MFRP and its interaction with CTRP5. Invest Ophthalmol Vis Sci 2006;47:5514-21.

Mark W. Johnson, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Moderator and presenter, Fluorescein Angiography Conference, Combined Meeting Club Jules Gonin and Retina Society, Cape Town, South Africa • Editorial Board Member, American Journal of Ophthalmology • Top Ten Reviewers, Archives of Ophthalmology • Reviewer, Ophthalmic Surgery, Lasers & Imaging Publications Huynh TH, Johnson MW. Delayed posttraumatic Propionibacterium acnes endophthalmitis in a child. Ophthalmic Surg Lasers Imaging 2006;37:314-6.

Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY, for the MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration.

N Engl J Med 2006;355:1419-31.

41

Faculty Honors, Recognition, and Publications

Mark Johnson, cont’d

Wu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration.

Clin Ophthalmol 2007 [in press].

Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, Schneider S, for the ANCHOR Study Group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006;355:1432-44.

Huynh TH, Johnson MW, Hackel RE. Bilateral proliferative retinopathy in chronic myelogenous leukemia. Retina 2007;27:124-5.

Aizman A, Johnson MW, Elner SG. Treatment of acute retinal necrosis syndrome with oral antiviral medications. Ophthalmology 2007;114:307-12.

Sieving PA, MacDonald IM, Khan NW. Juvenile X-linked retinoschisis. In: Heckenlively JR, Arden GB, Nusinowitz S, Holder G, Bach M, (eds). Principles and Practice of Clinical Electrophysiology of Vision, 2nd ed.

MIT Press, MA, 2006. Chap 73.

Regillo C, Holekamp N, Johnson MW, Kaiser PK, Schubert H, Schmidt-Efurth U, Spaide R. Retina and Vitreous (Section 12). Basic and Clinical Science Course 2008-2009. American Acad of Ophthalmology:San Francisco 2007 [in press].

Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A. Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Proc Natl Acad Sciences 2007;104:1679-84.

Comer GM, Johnson MW. Coats’ Disease and retinal telangiectasia. In: Albert DM, Jakobiec FA, (eds): Principles and Practice of Ophthalmology, 3rd ed. Philadelphia: WB Saunders, 2007 [in press].

Mirza RA, Johnson MW, Jampol LM. OCT use in evaluation of the vitreoretnal interface: a review. Surv Ophthalmol 2007;52:397421.

Khan NW, Wissinger B, Kohl S, Sieving PA. CNGB3 achromatopsia with progressive loss of residual cone function and impaired rodmediated function. Invest Ophthalmol Vis Sci 2007 [in press].

Hemant Khanna, Ph.D.

Johnson TM, Johnson MW. Epiretinal membrane. In: Yanoff M, Duker J, (eds): Ophthalmology, 3rd ed. St. Louis: Mosby 2007 [in press].

Publications Khanna H, Akimoto M, Siffroi-Fernandez S, Friedman JS, Hicks D, Swaroop A. Retinoic acid regulates the expression of photoreceptor transcription factor NRL. J Biol Chem 2006;281:27327-34.

Huynh TH, Johnson MW. The behavior of surgically repaired idiopathic macular holes in the setting of subsequent cystoid macular edema. Retina 2007 [in press].

Ronan SM, Yoganathan P, Chien FY, Corcóstegui IA, Blumenkranz MS, Deramo VA, Elner SG, Fastenberg DA, Johnson MW, Lopez M, Mateo C, Moshfeghi DM, Navarro R, Rosenblatt BJ, Sanislo SR, Saxe SJ, Zacks DN. Retinal pigment epithelium tears after intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina 2007;27:535-40.

42

Awards/Honors/Leadership Reviewer, Visual Neuroscience Publications Petersen-Jones S, Tuntivanich N, MontianiFerreira M, Khan NW. ERGs of dog and chicken. In: Heckenlively JR, Arden GB, Nusinowitz S, Holder G, Bach M, (eds).

Principles and Practice of Clinical Electrophysiology of Vision, 2nd ed. MIT Press, MA, 2006. Chap 82.

Boyer DS, Antoszyk AN, Awh CC, Bhisitkul RB, Shapiro H, Acharya NR, MARINA Study Group. Subgroup analysis of the MARINA study of ranibizumab in neovascular age-related macular degeneration. Ophthalmology 2007;114:246-52.

Huynh TH, Johnson MW, Hackel RE. Subretinal Candida albicans abscesses responsive to oral voriconazole. Retinal Cases and Brief Reports 2007 [in press].

Naheed W. Khan, Ph.D.

Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A. Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Proc Natl Acad Sci 2007;104:1679-84.

Cideciyan AV, Aleman TS, Jacobson SG, Khanna H, Sumaroka A, Aguirre GK, Schwartz SB, Windsor EAM, He S, Chang B, Stone EM, Swaroop A. Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis.

Human Mutation 2007 [in press].

university of michigan kellogg eye center

Andrei L. Kindzelski, M.D., Ph.D. Publications Jarvis JN, Petty HR, Tang Y, Frank MB, Tessier PA, Dozmorov I, Jiang K, Kindzelskii A, Chen Y, Cadwell C, Turner M, Szodoray P, McGhee JL, Centola M. Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther 2006;8:R154.

Kummer U, Zobeley J, Brasen J, Fahmy R, Kindzelskii A, Petty A, Clark AJ, Petty HR. Elevated glucose concentrations promote receptor-independent activation of adherent human neutrophils: an experimental and computational approach. Biophys J 2007;92:2597-607.

Thellea K. Leveque, M.D., M.P.H. Grants see grants, pages 48-51 Awards/Honors/Leadership Contributing expert, “Women and the Aging Eye,” Mind, Body & Soul Publications Leveque TK, Yu L, Musch DC, Chervin RD, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep and Breathing 2007 [in press].

Erika M. Levin, M.D. Grants see grants, pages 48-51 Publications Holmes JM, Leske DA, Cole SR, Chandler DL, Repka MX and the Nasolacrimal Duct Obstruction Questionnaire Study Group. A symptom survey and quality of life questionnaire for nasolacrimal duct obstruction in children. Ophthalmology 2006;113:1675-80.

Paul R. Lichter, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Associate Editor, American Journal of Ophthalmology • Secretary General, Academia Ophthalmologica Internationalis • Max Forbes Lectureship in Glaucoma, Columbia University • William and Grace Snyder Lecturer, Pearls X Conference, Vanderbilt University

Faculty Honors, Recognition, and Publications

Publications Musch DC, Gillespie BW, Niziol LM, Janz NK, Wren PA, Rockwood EJ, Lichter PR; Collaborative Initial Glaucoma Treatment Study Group. Cataract extraction in the collaborative initial glaucoma treatment study: incidence, risk factors, and the effect of cataract progression and extraction on clinical and quality-of-life outcomes. Arch Ophthalmol 2006;124:1694-1700.

Hudson HL, Lane SS, Heier JS, Stulting RD, Singerman L, Lichter PR, Sternberg P, Chang DF; IMT-002 Study Group. Implantable miniature telescope for the treatment of visual acuity loss resulting from end-stage age-related macular degeneration: 1-year results.

Ophthalmology 2006;113:1987-2001.

Ayala-Lugo RM, Pawar H, Reed DM, Lichter PR, Moroi SE, Page M, Eadie J, Azocar V, Maul E, Ntim-Amponsah C, Bromley W, Obeng-Nyarkoh E, Johnson AT, Kijek TG, Downs CA, Johnson JM, Perez-Grossmann RA, Guevara-Fujita ML, Fujita R, Wallace MR, Richards JE. Variation in optineurin (OPTN) allele frequencies between and within populations. Mol Vis 2007;13:151-63.

Hewitt AW, Samples JR, Allingham RR, Jarvela I, Kitsos G, Krishnadas SR, Richards JE, Lichter PR, Petersen MB, Sundaresan P, Wiggs JL, Mackey DA, Wirtz MK. Investigation of founder effects for the Thr377Met myocilin mutation in glaucoma families from differing ethnic backgrounds. Mol Vis 2007;13:487-92.

Jampel HD, Frick KD, Janz NK, Wren PA, Musch DC, Rimal R, Lichter PR. Depression and mood indicators in newly diagnosed glaucoma patients. Am J Ophthalmol 2007 [in press] epub ahead of print.

Janz NK, Wren PA, Guire KE, Musch DC, Gillespie BW, Lichter PR. Fear of blindness in the Collaborative Initial Glaucoma Treatment Study patterns and correlates over time.

Ophthalmology 2007 [in press].

Michael J. Lipson, O.D.

Shahzad I. Mian, M.D.

Sayoko E. Moroi, M.D., Ph.D.

Grants see grants, pages 48-51

Grants see grants, pages 48-51

Awards/Honors/Leadership • Best Doctors in America • Board of Directors, Midwest Eye Bank • Annual Program Co-Chair 2007, Michigan Society of Eye Physicians and Surgeons • Program Directors’ Council – Teaching and Learning Symposium Committee, American Academy of Ophthalmology Publications Lelli GJ, Musch DC, Gupta A, Farjo QA, Nairus TM, Mian SI. Ophthalmic cyclosporine use in ocular graft-versus-host disease.

Cornea 2006;25:635-8.

Awards/Honors/Lectures • Best Doctors in America • Guide to America’s Top Ophthalmologists 2006-2007

Mian SI, Soong HK, Patel SV, Juhasz T. In vivo femtosecond laser-assisted posterior lamellar keratoplasty: rabbit model. Cornea 2006;25:1205-9.

Djotyan GP, Soong HK, Mian S, Fernandez DC, Kurtz RM, Juhasz T. Finite-element modeling of posterior lamellar keratoplasty: construction of theoretical nomograms for induced refractive errors. Ophthalmic Res 2006;38:329-34.

Publications Radenbaugh PA, Goyal A, McLaren NC, Reed DM, Musch DC, Richards JE, Moroi SE. Concordance of aqueous humor flow in the morning and at night in normal humans.

Invest Ophthalmol Vis Sci 2006;47:4860-4.

Mandal MN, Vasireddy V, Reddy GB, Wang X, Moroi SE, Pattnaik BR, Hughes BA, Heckenlively JR, Hitchcock PF, Jablonski MM, Ayyagari R. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 2006;47:5505-13.

Eisengart J, Goings L, Prusak R, Hackel R, Archer S, Moroi SE. Surgical management of unilateral glaucoma associated with Poland sequence. Arch Ophthalmol 2006;124:1206-7.

Mian S, Nairus TM, Sugar A. Femtosecond laser-assisted LASIK. In: Vajpayee R, ed.

Step by Step LASIK Surgery. London:Martin Dunitz UK/Taylor & Francis; 2006.

Bruno CA, Moroi SE. Plateau iris and acute closed-angle glaucoma following retinal detachment repair. Glaucoma Today 2006 (July-August):37-9.

Johnson CS, Mian S, Moroi SE, Afshari NA. Role of corneal elasticity in damping of intraocular pressure. Invest Ophthalmol Vis Sci 2007;48:2540-4.

Bruno CA, Fisher GJ, Moroi SE. Is “scarless” wound healing’ applicable to glaucoma surgery? Expert Rev Ophthalmol 2007;2:79-90.

Shtein R, Stahl R, Saxe S, Mian SI. Herpes simplex keratitis after intravitreal triamcinolone acetonide. Cornea 2007;26:641-2.

Mian SI, Shtein R, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intralase. J Cataract Refract Surg 2007 [in press].

Mian SI, Shtein R. Femtosecond laser-assisted corneal surgery. Curr Opinion Ophthalmol 2007;18:295-9.

Grants see grants, pages 48-51

Mian SI, Agarwal R. Cystoid macular edema.

In: Henderson B, (ed.): Essentials of Cataract Surgery, Thorofare, Slack 2007 [in press]

Publications Lipson MJ, Sugar A. Corneal reshaping: is it a good alternative to refractive surgery? Curr Opin Ophthalmol 2006;17:394-9.

Ahmad OR, Mian SI, Sugar A. Future of keratoplasty. In: Brightbill FS (ed.): Corneal Surgery, St. Louis:CV Mosby 2007 [in press].

Lipson MJ, Musch DC. Synergeyes vs. soft toric lenses: vision-related quality of life.

Optom Vis Sci 2007 [in press].

Ayala-Lugo RM, Pawar H, Reed DM, Lichter PR, Moroi SE, Page M, Eadie J, Azocar V, Maul E, Ntim-Amponsah C, Bromley W, Obeng-Nyarkoh E, Johnson AT, Kijek TG, Downs CA, Johnson JM, Perez-Grossmann RA, Guevara-Fujita ML, Fujita R, Wallace MR, Richards JE. Variation in optineurin (OPTN) allele frequencies between and within populations. Mol Vis 2007;13:151-63.

McLaren N, Reed DM, Musch DC, Downs CA, Higashi ME, Santiago C, Radenbaugh PA, Allingham RR, Richards JE, Moroi SE. Evaluation of the beta2-adrenergic receptor gene as a candidate glaucoma gene in 2 ancestral populations. Arch Ophthalmol 2007;125:105-11.

Johnson CS, Mian S, Moroi SE, Afshari NA. Role of corneal elasticity in damping of intraocular pressure. Invest Ophthalmol Vis Sci 2007;48:2540-4.

Lipson MJ. Long-term clinical outcomes of overnight corneal reshaping in children and adults. Eye and Contact Lens 2007 [in press].

2007 annual Report

43

Faculty Honors, Recognition, and Publications

David C. Musch, Ph.D., M.P.H.

Mian SI, Shtein R, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intralase. J Cataract Refract Surg 2007 [in press].

Demirci H, Nelson CC. Ultrasound biomicroscopy of the upper eyelid structures in normal eyelids. Ophthal Plast Reconstr Surg 2007;23:122-5.

Awards/Honors/Leadership • Chair, Special Emphasis Grant Review Panel, NEI/NIH • Member, Editorial Board, Ophthalmology • External referee, Michael Smith Foundation for Health Research, BC, Canada • Methodologist, Cornea Panel, Ophthalmic Technology Assessment Committee, American Academy of Ophthalmology • Member, Consulting Editorial Board, Journal of Neuro-Ophthalmology • Reviewer, National Medical Research Council, Singapore • Member, Advisory Group, Cochrane Collaboration Eyes and Vision Group US Project • Consultant, Ophthalmic Devices Panel, Medical Devices Advisory Committee, Food and Drug Administration

Fahim DK, Frueh BR, Musch DC, Nelson CC. Complications of pegged and non-pegged hydroxyapatite orbital implants. Ophthal Plast Reconstr Surg 2007;23:206-10.

Fahim, D, Frueh, BR, Musch, DC, Nelson, CC. Complications of pegged and non-pegged hydroxyapatite orbital implants. Ophthal Plast Reconstr Surg 2007;23:206-10.

Garcia DD, Farjo Q, Musch DC, Sugar A. The effect of prophylactic oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. Cornea 2007 [in press].

Bikash R. Pattnaik, Ph.D.

Publications Musch DC, Gillespie BW, Niziol LM, Janz NK, Wren PA, Rockwood EJ, Lichter PR; Collaborative Initial Glaucoma Treatment Study Group. Cataract extraction in the collaborative initial glaucoma treatment study: incidence, risk factors, and the effect of cataract progression and extraction on clinical and quality-of-life outcomes. Arch Ophthalmol 2006;124:1694-1700.

Wu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration.

Clin Ophthalmol 2007 [in press].

Grants see grants, pages 48-51

Christine C. Nelson, M.D. Grants see grants, pages 48-51

Radenbaugh PA, Goyal A, McLaren NC, Reed DM, Musch DC, Richards JE, Moroi SE. Concordance of aqueous humor flow in the morning and at night in normal humans.

Invest Ophthalmol Vis Sci 2006;47:4860-4.

Pramanik S, Musch DC, Sutphin JE, Farjo AA. Extended long-term outcomes of penetrating keratoplasty for keratoconus. Ophthalmology 2006;113:1633-8.

Thoms SS, Musch DC, Soong HK. Postoperative endophthalmitis associated with sutured versus unsutured clear-corneal cataract incisions. Br J Ophthalmol 2007;91:728-30.

Lipson MJ, Musch DC. Synergeyes vs. soft toric lenses: vision-related quality of life.

Optom Vis Sci 2007 [in press].

44

Jampel HD, Frick KD, Janz NK, Wren PA, Musch DC, Rimal R, Lichter PR. Depression and mood indicators in newly diagnosed glaucoma patients. Am J Ophthalmol 2007 [in press] epub ahead of print.

Janz NK, Wren PA, Guire KE, Musch DC, Gillespie BW, Lichter PR. Fear of blindness in the Collaborative Initial Glaucoma Treatment Study patterns and correlates over time.

Ophthalmology 2007 [in press].

Lelli GJ, Musch DC, Gupta A, Farjo QA, Nairus TM, Mian SI. Ophthalmic cyclosporine use in ocular graft-versus-host disease.

Cornea 2006;25:635-8.

McLaren N, Reed DM, Musch DC, Downs CA, Higashi ME, Santiago C, Radenbaugh PA, Allingham RR, Richards JE, Moroi SE. Evaluation of the beta2-adrenergic receptor gene as a candidate glaucoma gene in 2 ancestral populations. Arch Ophthalmol 2007;125:105-11.

Leveque TK, Yu L, Musch DC, Chervin RD, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea.

Sleep and Breathing 2007 [in press]

Awards/Honors/Leadership • Best Doctors in America • Guide to America’s Top Ophthalmologists • Editorial Advisory Board, EyeNet, American Academy of Ophthalmology • Leadership Conference Committee for Strategic Planning, American Society of Ophthalmic Plastic and Reconstructive Surgery • Chair, Preceptor Committee, American Society of Ophthalmic Plastic and Reconstructive Surgery Publications Nelson CC. Cutler Beard procedure for upper eyelid reconstruction. In: Toriumi D, ed. Facial Plastic and Reconstructive Surgery. Philadelphia:Lippincott Williams and Wilkins; 2006.

Demirci H, Nelson CC, Shields CL, Eagle RC, Jr, Shields JA. Eyelid sebaceous carcinoma associated with Muir-Torre Syndrome in two cases. Ophthal Plast Reconstr Surg 2007;23:77-9.

university of michigan kellogg eye center

Publications Mandal MN, Vasireddy V, Reddy GB, Wang X, Moroi SE, Pattnaik BR, Hughes BA, Heckenlively JR, Hitchcock PF, Jablonski MM, Ayyagari R. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 2006;47:5505-13.

Hemant Pawar, Ph.D. Publications Ayala-Lugo RM, Pawar H, Reed DM, Lichter PR, Moroi SE, Page M, Eadie J, Azocar V, Maul E, Ntim-Amponsah C, Bromley W, Obeng-Nyarkoh E, Johnson AT, Kijek TG, Downs CA, Johnson JM, Perez-Grossmann RA, Guevara-Fujita ML, Fujita R, Wallace MR, Richards JE. Variation in optineurin (OPTN) allele frequencies between and within populations. Mol Vis 2007;13:151-63.

Rozsa FW, Scott KM, Pawar H, Samples JR, Wirtz MK, Richards JE. Differential expression profile prioritization of positional candidate glaucoma genes: the GLC1C locus. Arch Ophthalmol 2007;125:117-27.

Howard R. Petty, Ph.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • First place, Ann Arbor SPARK Entrepreneur awards Publications Jarvis JN, Petty HR, Tang Y, Frank MB, Tessier PA, Dozmorov I, Jiang K, Kindzelskii A, Chen Y, Cadwell C, Turner M, Szodoray P, McGhee JL, Centola M. Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther 2006;8:R154.

Sitrin RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. Selective localization of recognition complexes for leukotriene B4 and formyl- Met- Leu- Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol 2006;177:8177-84.

Faculty Honors, Recognition, and Publications

Kummer U, Zobeley J, Brasen J, Fahmy R, Kindzelskii A, Petty A, Clark AJ, Petty HR. Elevated glucose concentrations promote receptor-independent activation of adherent human neutrophils: an experimental and computational approach. Biophys J 2007;92:2597-607.

Jarvis JN, Jiang K, Petty HR, Centola M. Neutrophils: the fogotten cell in JIA disease pathogenesis. Pediatr Rheumatol Online J 2007;5:13.

Huang J-B, Clark AJ, Petty HR. Preliminary report: the hexosamine biosynthesis pathway negatively regulates IL-2 production by Jurkat T cells. Cell Immunol 2007 [in press].

Petty HR. Fluorescence microscopy: established and emerging methods, experimental strategies, and applications in immunology.

Microsc Res Tech 2007 [in press].

Donald G. Puro, M.D., Ph.D. Grants see grants, pages 48-51 Awards/Honors/Lectures • Editorial Board Member, Microcirculation Publications Puro DG. Physiology and pathobiology of the pericyte-containing retinal microvasculature: new developments. Microcirculation 2007;14:1-10.

Kobayashi T, Puro DG. Loss of insulin-mediated vasoprotection: early effect of diabetes on pericyte-containing microvessels of the retina.

Invest Ophthalmol Vis Sci 2007;48:2350-5.

Liao SD, Puro DG. NAD+-induced vasotoxicity in the pericyte-containing microvasculature of the rat retina: effect of diabetes. Invest Ophthalmol Vis Sci 2007;47:5032-8.

Puro DG. Physiology and pathobiology of the pericyte-containing retinal microvasculature: roles of ion channels and transporters. In: Tombran-Tink J, Barnstable C (eds.). Ocular Transporters in Diseases and Drug Delivery Totowa, NJ: Humana Press, 2007 [in press].

Venkat N. Reddy, Ph.D. Publications Shibuya M, Okamoto H, Nozawa T, Utsumi J, Reddy VN, Echizen H, Tanaka Y, Iwata T. Proteomic and transcriptomic analyses of retinal pigment epithelial cells exposed to REF-1/TFPI-2. Invest Ophthalmol Vis Sci 2007;48:516-21.

Julia E. Richards, Ph.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Reviewer, The Glaucoma Foundation • Reviewer, Fight for Sight.

• Member, Scientific Advisory Board, The Glaucoma Foundation • Member, Steering Committee, Multicenter Study to Map Novel Genes for Fuchs Corneal Endothelial Dystrophy, Case Western Reserve University Publications Radenbaugh PA, Goyal A, McLaren NC, Reed DM, Musch DC, Richards JE, Moroi SE. Concordance of aqueous humor flow in the morning and at night in normal humans.

Invest Ophthalmol Vis Sci 2006;47:4860-4.

Mimiwati Z, Mackey DA, Craig JE, Mackinnon JR, Rait JL, Liebelt JE, Ayala-Lugo R, Vollrath D, Richards JE. Nail-patella syndrome and its association with glaucoma: a review of eight families. Br J Ophthalmol 2006;90:1505-9.

Ayala-Lugo RM, Pawar H, Reed DM, Lichter PR, Moroi SE, Page M, Eadie J, Azocar V, Maul E, Ntim-Amponsah C, Bromley W, Obeng-Nyarkoh E, Johnson AT, Kijek TG, Downs CA, Johnson JM, Perez-Grossmann RA, Guevara-Fujita ML, Fujita R, Wallace MR, Richards JE. Variation in optineurin (OPTN) allele frequencies between and within populations. Mol Vis 2007;13:151-63.

Hewitt AW, Samples JR, Allingham RR, Jarvela I, Kitsos G, Krishnadas SR, Richards JE, Lichter PR, Petersen MB, Sundaresan P, Wiggs JL, Mackey DA, Wirtz MK. Investigation of founder effects for the Thr377Met Myocilin mutation in glaucoma families from differing ethnic backgrounds. Mol Vis 2007;13:487-92.

Hewitt AW, Bennett SL, Richards JE, Dimasi DP, Booth AP, Inglehearn C, Yamamoto T, Fingert JH, Heon E, Craig JE, Mackey DA. Myocilin Gly252Arg mutation and glaucoma of intermediate severity in Caucasian individuals. Arch Ophthalmol 2007;125:98-104.

McLaren N, Reed DM, Musch DC, Downs CA, Higashi ME, Santiago C, Radenbaugh PA, Allingham RR, Richards JE, Moroi SE. Evaluation of the beta2-adrenergic receptor gene as a candidate glaucoma gene in 2 ancestral populations. Arch Ophthalmol 2007;125:105-11.

Rozsa FW, Scott KM, Pawar H, Samples JR, Wirtz MK, Richards JE. Differential expression profile prioritization of positional candidate glaucoma genes: the GLC1C locus. Arch Ophthalmol 2007;125:117-27.

2007 annual Report

Downs K, Zacks DN, Caruso R, Karoukis AJ, Branham K, Yashar BM, Haimann MH, Trzupek K, Meltzer M, Blain D, Richards JE, Weleber RG, Heckenlively JR, Sieving PA, Ayyagari R. Molecular testing for hereditary retinal disease as part of clinical care. Arch Ophthalmol 2007;125:252-8.

Trager EH, Khanna R, Marrs A, Siden L, Branham KE, Swaroop A, Richards JE. Madeline 2.0 PDE: A new program for local and web-based pedigree drawing.

Bioinformatics 2007 [in press].

Frank W. Rozsa, Ph.D. Awards/Honors/Leadership Invited speaker, International Congress of Eye Research, Buenos Aires, Argentina Publications Rozsa FW, Scott KM, Pawar H, Samples JR, Wirtz MK, Richards JE. Differential expression profile prioritization of positional candidate glaucoma genes: the GLC1C locus. Arch Ophthalmol 2007;125:117-27.

Stephen J. Saxe, M.D. Publications Shtein R, Stahl R, Saxe S, Mian SI. Herpes simplex keratitis after intravitreal triamcinolone acetonide. Cornea 2007;26:641-2.

Ronan SM, Yoganathan P, Chien F, Corcostegui IA, Blumenkranz MS, Deramo VA, Elner SG, Fastenberg DA, Johnson MW, Lopez M, Mateo C, Moshfeghi DM, Navarro R, Rosenblatt BJ, Sanislo SR, Saxe SJ, Zacks DN. Retinal pigment epithelium tears after intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina 2007;27:535-40.

Roni M. Shtein, M.D. Publications Shtein R, Stahl R, Saxe S, Mian SI. Herpes simplex keratitis after intravitreal triamcinolone acetonide. Cornea 2007;26:641-2.

Mian SI, Shtein R, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intralase. J Cataract Refract Surg 2007 [in press].

Mian SI, Shtein R. Femtosecond laser-assisted corneal surgery. Curr Opinion Ophthalmol 2007;18:295-9.

Sugar A, Mintz R. Koch-Weeks bacillus. In: Roy FH, Fraunfelder F (eds): Current Ocular Therapy, 6th ed., Phila: WB Saunders, 2007 [in press].

45

Faculty Honors, Recognition, and Publications

H. Kaz Soong, M.D.

Patel SV, Sugar A. Dermatophytosis. In: Roy FH, Fraunfelder F (eds): Current Ocular Therapy, 6th ed, Phila:WB Saunders, 2007 [in press].

Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Invited speaker, Union of Bulgarian Ophthalmologists, Plovdiv, Bulgaria • Invited speaker, Pan-American Association of Ophthalmology, Cancun, Mexico

Sugar A, Mintz R. Koch-Weeks bacillus. In: Roy FH, Fraunfelder F (eds): Current Ocular Therapy, 6th ed, Phila: WB Saunders, 2007 [in press].

Ahmad OR, Mian SI, Sugar A. Future of keratoplasty. In: Brightbill FS (ed.): Corneal Surgery, St. Louis:CV Mosby 2007 [in press].

Publications Mian S, Soong HK, Patel S, Juhasz T. In vivo femtosecond laser-assisted posterior lamellar keratoplasty in rabbits. Cornea 2006;25:1205-9.

Garcia DD, Farjo Q, Musch DC, Sugar A. The effect of prophylactic oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. Cornea 2007 [in press].

Patel S, Soong H. Indications and contraindications in lamellar grafting. In: Brightbill F, Farjo A, eds. Corneal Surgery: Theory, Technique, and Tissue. Philadelphia:Elsevier, 2006.

Anand Swaroop, Ph.D. Grants see grants, pages 48-51

Djotyan GP, Soong HK, Mian S, Fernandez DC, Kurtz RM, Juhasz T. Finite-element modeling of posterior lamellar keratoplasty: construction of theoretical nomograms for induced refractive errors. Ophthalmic Res 2006;38:329-34.

Patel S, Soong H. Femtosecond laser-assisted lamellar keratoplasty. In: Barraquer C, Malbran E, Maldonado-Bas A, eds. Queratoplastia Laminar. Panama: Highlights of Ophthalmology International 2007 [in press].

Thoms SS, Musch D, Soong HK. Postoperative endophthalmitis associated with sutured versus unsutured clear-corneal cataract incisions. Br J Ophthalmol 2007;91:728-30.

Alan Sugar, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Immediate Past President 2006-2008, Cornea Society • Chair, Committee on Ophthalmic Technology Assessment, American Academy of Ophthalmology

Publications Friedman JS, Chang B, Kannabiran C, Chakarova C, Singh HP, Jalali S, Hawes NL, Branham K, Othman M, Filippova E, Thompson DA, Webster AR, Andreasson S, Jacobson SG, Bhattacharya SS, Heckenlively JR, Swaroop A. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration.

Am J Hum Genet 2006;79:1059-70.

Publications Mian S, Nairus TM, Sugar A. Femtosecond laser-assisted LASIK. In: Vajpayee R, ed.

Step by Step LASIK Surgery. London:Martin Dunitz UK/Taylor & Francis; 2006.

Lipson MJ, Sugar A. Corneal reshaping: is it a good alternative to refractive surgery? Curr Opin Ophthalmol 2006;17:394-9.

46

Awards/Honors/Lectures • Editorial Board, Investigative Ophthalmology & Visual Science • Editorial Review Board, Molecular Vision • Director, International Resource for X-Linked Retinitis Pigmentosa, Foundation Fighting Blindness • Reviewer, National Science Foundation • Organizer/moderator, “Photoreceptor Transcriptional Regulation,” XVII International Congress of Eye Research, Buenos Aires, Argentina • Member, Stem Cell Biology Group, Foundation Fighting Blindness • Member, Genetics Advisory Committee, Age-Related Eye Disease Study 2, NEI • Member, National Scientific Advisory Council, American Federation for Aging Research • Distinguished Faculty Lectureship Award, University of Michigan Medical School • The Foundation Fighting Blindness Board of Directors Award

MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE, Akimoto M, Swaroop A, Sowden JC, Ali RR. Retinal repair by transplantation of photoreceptor precursors.

Nature 2006;444:203-7.

university of michigan kellogg eye center

Khanna H, Akimoto M, Siffroi-Fernandez S, Friedman JS, Hicks D, Swaroop A. Retinoic acid regulates the expression of photoreceptor transcription factor NRL. J Biol Chem 2006;281:27327-34.

Cheng H, Aleman TS, Cideciyan AV, Khanna R, Jacobson SG, Swaroop A. In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development. Hum Mol Genet 2006;15:2588-602.

Li M, Atmaca-Sonmez P, Othman M, Branham KE, Khanna R, Wade MS, Li Y, Liang L, Zareparsi S, Swaroop A, Abecasis GR. CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet 2006;38:1049-54.

Kanda A, Friedman JS, Nishiguchi KM, Swaroop A. Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity. Hum Mutat 2007;28:589-98.

Parapuram S, Swaroop A. Mouse models, microarrays and genetic networks in retinal development and degenerative disease. In: Chalupa LM, Williams RW, eds. Eye, Retina, and Visual System of the Mouse, MIT Press, 2007.

Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A. Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Proc Natl Acad Sci 2007;104:1679-84.

Cideciyan AV, Aleman TS, Jacobson SG, Khanna H, Sumaroka A, Aguirre GK, Schwartz SB, Windsor EAM, He S, Chang B, Stone EM, Swaroop A. Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis.

Human Mutation 2007 [in press] Trager EH, Khanna R, Marrs A, Siden L, Branham KE, Swaroop A, Richards JE. Madeline 2.0 PDE: A new program for local and web-based pedigree drawing. Bioinformatics 2007 [in press].

Ronan SM, Nusinowitz S, Swaroop A, Heckenlively JR. Senile panretinal cone dysfunction in age-related macular degeneration (AMD): a report of 52 AMD patients compared to age-matched control. Ophthalmology 2007 [in press].

Faculty Honors, Recognition, and Publications

Debra A. Thompson, Ph.D. Grants see grants, pages 48-51 Publications Friedman JS, Chang B, Kannabiran C, Chakarova C, Singh HP, Jalali S, Hawes NL, Branham K, Othman M, Filippova E, Thompson DA, Webster AR, Andreasson S, Jacobson SG, Bhattacharya SS, Heckenlively JR, Swaroop A. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration.

Am J Hum Genet 2006;79:1059-70.

Kurth I, Thompson DA, Ruther K, Feathers KL, Chrispell JD, Schroth J, McHenry CL, Schweizer M, Skosyrski S, Gal A, Hubner CA. Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function. Mol Cell Biol 2007;27:1370-9.

Jacobson SG, Cideciyan AV, Aleman TS, Sumaroka A, Schwartz SB, Windsor EA, Roman AJ, Heon E, Stone EM, Thompson DA. RDH12 and RPE65, visual cycle genes causing Leber congenital amaurosis, differ in disease expression. Invest Ophthalmol Vis Sci 2007;48:332-8.

Schuster A, Janecke AR, Wilke R, Schmid E, Thompson DA, Utermann G, Wissinger B, Zrenner E, Gal A. The phenotype of earlyonset retinal degeneration in persons with RDH12 mutations. Invest Ophthalmol Vis Sci 2007;48:1824-31.

Susan S. Thoms, M.D. Awards/Honors/Leadership • Best Doctors in America • Editorial Board Member, Comprehensive Ophthalmology Update Publications Thoms SS, Musch DC, Soong HK. Postoperative endophthalmitis associated with sutured versus unsutured clear-corneal cataract incisions. Br J Ophthalmol 2007;91:728-30.

Jonathan D. Trobe, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • Chandler Lecture, Massachusetts Eye and Ear Infirmary, Boston • Susan Alper Lecture, Washington Hospital Center, Washington, DC • Keynote lecture, European Neuro Ophthalmology Meeting, Istanbul, Turkey

Publications Mizrachi IB, Trobe JD, Gebarski SS, Garton H. Papilledema in the assessment of ventriulo megaly. J Neuroophthalmol 2006;26:260-3.

Hirunwiwatkul P, Trobe JD. Optic neuropathy associated with periostitis in relapsing polychondritis. J Neuroophthalmol 2007;27:16-21.

Chong DY, Hirunwiwatkul P, McKeever PE, Trobe JD. Papilledema in obstructive hydrocephalus caused by giant cell astrocytoma of tuberous sclerosis. J Neuroophthalmol 2007;27:50-4.

Trobe JD, Kashii S. 16th International NeuroOphthalmology Society Meeting, 3rd Asian Neuro-Ophthalmology Society Meeting, and 44th Japanese Neuro-Ophthalmology Meeting, Tokyo, Nov 29-Dec 2, 2006.

J Neuroophthalmol 2007;27:79-82.

Hirunwiwatkul P, Trobe JD, Blaivas M. Lymphoplasmacyte-rich meningioma mimicking idiopathic hypertrophic pachymeningitis.

J Neuroophthalmol 2007;27:91-4.

Andrew K. Vine, M.D. Grants see grants, pages 48-51 Awards/Honors/Leadership • Best Doctors in America • America’s Top Doctors for Cancer Publications Collaborative Ocular Melanoma Study (COMS) Group. The COMS randomized trial of Iodine 125 brachytherapy for choroidal melanoma. Twelve-year mortality rated and prognostic factors: COMS report #28. Arch Ophthalmol 2006;124:1684-93.

Jennifer S. Weizer, M.D. Publications Weizer JS. Acute angle-closure glaucoma.

Up-to-Date, 2006 [in press].

Weizer JS, Asrani S, Stinnett SS, Herndon LW. The clinical utility of dynamic contour tonometry and ocular pulse amplitude.

J Glaucoma 2007 [in press].

Rebecca A. Wu, M.D. Publications Wu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration.

Clin Ophthalmol 2007 [in press].

Dongli Yang, M.D., Ph.D. Publications Yang D, Elner SG, Bian Z-M, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species production through mitochondria and NADPH oxidase in cultured RPE cells. Expe Eye Res 2007 [in press].

David N. Zacks, M.D., Ph.D. Grants see grants, pages 48-51 Publications Downs K, Zacks DN, Caruso R, Karoukis AJ, Branham K, Yashar BM, Haimann MH, Trzupek K, Meltzer M, Blain D, Richards JE, Weleber RG, Heckenlively JR, Sieving PA, Ayyagari R. Molecular testing for hereditary retinal disease as part of clinical care. Arch Ophthalmol 2007;125:252-8.

Leveque TK, Yu L, Musch DC, Chervin RC, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep and Breathing 2007 [in press].

Ronan SM, Yoganathan P, Chien Y, Corcostegui IA , Blumenkranz MS, Deramo VA, Elner SG, Fastenberg DA, Johnson MW, Lopez M, Mateo C, Moshfeghi DM, Navarro R, Rosenblatt BJ, Sanislo SR, Saxe SJ, Zacks DN. Retinal pigment epithelium tears after intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina 2007;27:535-40.

Zacks DN, Boehlke C, Richards AL, Zheng QD. Photoreceptor neuroprotection: The role of the FAS signaling pathway. Arch Ophthalmol 2007 [in press].

Weizer JS, Lee PP. Primary open-angle glaucoma. Atlas of Glaucoma, 2nd ed. Informa Healthcare, 2007 [in press].

2006 2007 annual Report

47

grants

Faculty Name Source ID Project Title R. Ayyagari, Ph.D. NIH R01-EY13198-06

R01-EY13198-06S1 FFB

Macular Degeneration: Genetics of 4 Distinct Phenotypes Center for the Study of Retinal Degenerative Diseases

T. Bergstrom, M.D. NIH/Clinical Trial U10-EY10439-14 Ocular Hypertension Treatment Study (OHTS) Coordinating Center: Washington University M. Del Monte, M.D. NIH/Clinical Trial U10-EY11751 Pediatric Eye Disease Investigator Group Multiple Projects, Coordinating Center: Jaeb Alcon/Clinical Trial Betoptic S Compared to Timolol Gel Forming Solution in Pediatric Patients with Glaucoma or Ocular Hypertension J. Demb, Ph.D.

NIH R01-EY14454-03 RPB Sloan Foundation

Functional Circuitry of Visual Adaptation Career Development Award Sloan Research Fellowship

M. Eibschitz, M.D. Blind Children’s Center Improving Trabeculectomy Outcomes in Children with Human Amniotic Membrane S. Elner, M.D. NIH/Clinical Trial U10-EY14660 Multicenter Uveitis Steroid Treatment (MUST) Trial Coordinating Center: Johns Hopkins University V. Elner, M.D., Ph.D. NIH R01-EY09441-12

RPB

U-M Medical School

RPE-MΦ Binding: Ca++ & O2- Dependent AMD Responses Senior Scientific Investigator Award Translational Research Initiatives Program Grant

P. Gage, Ph.D. NIH R01-EY14126-04 Pitx 2: Molecular Mechanisms in Eye Development and Disease

RPB Special Scholars Award D. Green, Ph.D. NIH R01-EY10084-06 Clinical and Molecular Analysis of Oregon Eye Disease Subcontract with De-Ann Pillers, M.D., Ph.D., Oregon Health and Science University J. Heckenlively, M.D. NIH R01-EY07758-19 FFB

LMRI LMRI

Mouse Models of Human Hereditary Eye Diseases Center for the Study of Retinal Degenerative Diseases Macular Telangiectasia Research Project Mouse Models of Retinal Telangiectasia

P. Hitchcock, Ph.D. NIH R01-EY07060-18 Neuronal Development, Injury and Regeneration in Retina

NIH T32-EY17878-06 Early Stage Training in the Neurosciences

Midwest Eye-Banks Function of Midkine B in the Developing and Regenerating Retina

FFB – Canada Identification and Function of Molecular Cues for Photoreceptor Regeneration in the Vertebrate Retina

48

university of michigan kellogg eye center

grants

Faculty Name Source ID Project Title

B. Hughes, Ph.D.

NIH P30-EY07003-21 NIH R01-EY08850-17 RPB

Core Center for Vision Research (four core modules) Ion Conductances in the Retinal Pigment Epithelium Lew R. Wasserman Award

M. Johnson, M.D. NIH/Clinical Trial N01-EY12113 Preservative-Free Triamcinolone Acetonide as an Adjunct to Photodynamic Therapy for Age-Related Macular Degeneration, Coordinating Center: Emmes

NIH/Clinical Trial U10-EY14351 Standard Care Versus Corticosteroid for Retinal Vein Occlusion (SCORE) Study, Coordinating Center: University of Wisconsin

Genentech, Inc./Clinical Trial Ranibizumab Compared with Visudyne Photodynamic Therapy for Subfoveal Neovascular Age-Related Macular Degeneration

Genentech, Inc./Clinical Trial Extension Study of Ranibizumab for Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

Genentech, Inc./Clinical Trial RhuFab V2 versus Sham for Minimally Classic or Occult Subfoveal Neovascular Age-Related Macular Degeneration

Genentech, Inc./Clinical Trial Ranibizumab in Naïve and Previously Treated Subjects with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration T. Leveque, M.D. NIH M01-RR00042 Prevalence of Obstructive Sleep Apnea in Patients with Central Serous Chorioretinopathy – funded by the General Clinical Research Center E. Levin, M.D. NIH/Clinical Trial U10-EY11751 Pediatric Eye Disease Investigator Group Multiple Projects, Coordinating Center: Jaeb P. Lichter, M.D. RPB Unrestricted Grant

VisionCare Ophthalmic Technologies/ VisionCare Ophthalmic Technologies Implantable

Clinical Trial Miniature Telescope (IMT) for Central Vision Impairment Associated with Age-Related Macular Degeneration and Other Maculopathies M. Lipson, O.D.

EyeVis L.L.C.

Stabilizing Myopia By Accelerated Reshaping Technique

S. Mian, M.D. NIH R01-EY14163-01 Femtosecond Laser Posterior Lamellar Keratoplasty Subcontract with Tibor Juhasz, Ph.D., University of California - Irvine

Midwest Eye-Banks Medical Student Fellowship

2007 annual Report

49

grants

Faculty Name Source ID Project Title

S. Moroi, M.D., Ph.D. Pfizer/Clinical Trial Xalacom Given in the Evening, Xalatan in the Evening, and Timolol S in the Morning for Open-angle Glaucoma or Ocular Hypertension

U-M Medical School Improving Trabeculectomy Outcome with Human Amniotic Membrane D. Musch, Ph.D., M.P.H. NIH R03-EY15860-02 Analysis of CIGTS Visual Field Data

NIH R03-EY15700-03 Concordance of Clinical and Quality of Life Measures Subcontract with Patricia Wren, Ph.D., M.P.H., Oakland University

Midwest Eye-Banks Long-Term Follow-up of Keratoconus Recipients C. Nelson, M.D.

Allergan

Educational grant (unrestricted)

H. Petty, Ph.D. NIH N01-HD-2-3342 Services in Support of the Perinatology Research Branch Subcontract with Wayne State University

NIH R01-CA74120-08 Signaling Dynamics of Leukocyte-Tumor Cell Interactions

NIH R01-AI51789-05 Mechanisms Regulating Neutrophil Activation in Pregnancy

NIH R01-AI60983-02 Lipid Raft Microdomains in Neutrophil Function Subcontract, Robert Sitrin, M.D., U-M Medical School

Wilson Foundation Signal Waves in Tumor Cell Killing: A Systems Biology Approach in Oncology

U-M Medical School Translational Research Initiatives Program Grant D. Puro, M.D., Ph.D. NIH R01-EY12507-08

NIH T32-EY013934

RPB

RPB

Physiology of Retinal Pericytes Vision Research Training Program Medical Student Fellowship Senior Scientific Investigator Award

J. Richards, Ph.D. NIH R01-EY09580-13 Expression Profile Approach to Glaucoma Gene Detection

NIH R01-EY11671-08 Molecular Genetics of Glaucoma and Related Disorders AHAF Genetic Risk Factors and Glaucoma Outcomes

Midwest Eye-Banks Student Fellowship

Fight for Sight Sequence Variants in CLCN3 and the Associated Risk of Glaucoma - Student Fellowship H. Kaz Soong, M.D. NIH R01-EY014456 Femtosecond Laser Enhanced Aqueous Outflow Facility Subcontract with Tibor Juhasz, Ph.D., University of California - Irvine A. Sugar, M.D. NIH/Clinical Trial U10-EY12358 Cornea Donor Study, Coordinating Center: Jaeb

NIH/Clinical Trial R01-EY016482 A Multi-Center Study to Map Genes for Fuchs Dystrophy Coordinating Center: Case Western Reserve University Lux Biosciences, Inc. A Randomized Dose-Ranging Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure Following Penetrating Keratoplasty

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university of michigan kellogg eye center

grants

Faculty Name Source ID Project Title

A. Swaroop, Ph.D. NIH R01-EY07961-18 X-Linked Retinitis Pigmentosa

NIH R01-EY11115-11 Molecular Mechanisms of Retina-Specific Gene Expression

NIH R01-EY16862-01 Genetic Variations in Age-Related Macular Degenerations

NIH P50-DK39255-19 Function of Ciliary Protein RPGR in Renal Epithelial Cells: Possible Implications for Renal-Retinal Disease, Subcontract, Roger Wiggins, M.D., U-M Medical School

NSF DBI 0543272 Integrated Biological Sequence Data Management Subcontract, Alfred Hero, Ph.D.,University of Michigan FFB Center for the Study of Retinal Degenerative Diseases FFB Resource Facility for X-linked Retinitis Pigmentosa and Age-Related Macular Degeneration

Canadian Institute of Health Research Functional Analysis of NRL: A Rod Photoreceptor Specific Transcription Factor Sramek Foundation Interactive and Integrated Genetic Databases for the Study of Age-Related Macular Degeneration

Thompson Foundation Macular Degeneration Research Project Fight for Sight Screen for Human Mutations in RD11, the Gene Responsible for the rd11 Mouse Retinopathy Student Fellowship D. Thompson, Ph.D. NIH R01-EY12298-05 RPE65 in Retinal Metabolism and Degeneration FFB Center for the Study of Retinal Degenerative Diseases

Midwest Eye-Banks Visual Cycle Mechanisms and Inherited Retinal Dystrophy - Student Stipend J. Trobe, M.D. NIH/Clinical Trial U10-EY09435 Longitudinal Optic Neuritis Study, Coordinating Center: Jaeb A. Vine, M.D. LMRI/Clinical Trial A Natural History Study of Macular Telangiectasia The MacTel Study D. Zacks, M.D., Ph.D. NIH K08-EY14705-05 Apoptosis in Retinal Detachments

RPB Career Development Award

Midwest Eye-Banks Intravitreal Linezolid in Rabbits: An Electrophysiologic and Histopathologic Analysis

Source Abbreviations AHAF - American Health Assistance Foundation FFB – Foundation Fighting Blindness LMRI - Lowy Medical Research Institute

NIH – National Institutes of Health NSF – National Science Foundation RPB – Research to Prevent Blindness

2007 annual Report

51

Department of Ophthalmology and Visual Sciences Faculty 52

university of michigan kellogg eye center

This is our mission: To solve the puzzles of blinding eye disease, To improve the qualit y of life for our patients,And to teach the next generation of vision scientis ts and clinicians.

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39. Susan G. Elner, M.D.

4. Paul R. Lichter, M.D.

40. Roni M. Shtein, M.D.

5. James G. Knaggs, M.D.

41. Victor M. Elner, M.D., Ph.D.

6. Susan S. Thoms, M.D.

42. Andrew K. Vine, M.D.

7. Richard E. Hackel, M.A., C.R.A.

43. Peter F. Hitchcock, Ph.D.

8. David C. Musch, Ph.D., M.P.H.

44. H. Kaz Soong, M.D.

9. Donna M. Wicker, O.D.

45. Donald G. Puro, M.D., Ph.D.

10. Bartley R. Frueh, M.D.

46. Michael W. Smith-Wheelock, M.D.

11. James L. Adams, M.D.

47. Jerome I. Finkelstein, M.D.

12. Shahzad I. Mian, M.D.

48. Theresa M. Cooney, M.D.

13. John R. Heckenlively, M.D.

49. David N. Zacks, M.D., Ph.D.

14. Frank W. Rozsa, Ph.D.

50. Helios T. Leung, Ph.D., O.D.

17. Wayne T. Cornblath, M.D. 18. Anand Swaroop, Ph.D.

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38. Howard R. Petty, Ph.D.

3. Piyush Kothary, Ph.D.

16. Michael J. Lipson, O.D. 12

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37. Philip J. Gage, Ph.D.

2. Monte A. Del Monte, M.D.

15. Stephen J. Saxe, M.D.

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1. Sayoko E. Moroi, M.D., Ph.D.

19. Naheed W. Khan, Ph.D. 20. Maya Eibschitz, M.D. 21. Thellea K. Leveque, M.D., M.P.H. 22. Jill E. Green, M.D.

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23. Radha Ayyagari, Ph.D. 6

24. Jennifer S. Weizer, M.D. 25. Bikash R. Pattnaik, Ph.D. 26. Dongli Yang, M.D., Ph.D. 27. Jonathan B. Demb, Ph.D. 28. Debra A. Thompson, Ph.D. 29. Steven M. Archer, M.D. 30. Gary S. Sandall, M.D. 31. Terry J. Bergstrom, M.D. 32. Donald S. Beser, M.D. 33. Gale A. Oren, M.I.L.S. 34. Alan Sugar, M.D. 35. Julia E. Richards, Ph.D. 36. Jonathan D. Trobe, M.D.

Design: David Murrel, Creative Director, U-M Department of Ophthalmology and Visual Sciences Contributing photographers: Scott Galvin, Paul Jaronski, Lin Jones, Martin Vloet, U-M Photo Services; Jennifer Burkheiser, Lin Goings, Richard Hackel, Robert Prusak, U-M Department of Ophthalmology and Visual Sciences; D.C. Goings Photography; U-M Bentley Historical Library

Not Pictured: Robert C. Arends, M.D. Christina A. Bruno, M.D. Morton S. Cox, M.D. Daniel G. Green, Ph.D. Adam S. Hassan, M.D. Bret A. Hughes, Ph.D. Ida L. Iacobucci, C.O. Mark W. Johnson, M.D. Harjeet Kaur, M.D. Hemant Khanna, Ph.D. Andrei L. Kindzelski, M.D., Ph.D. Erika M. Levin, M.D. Christine C. Nelson, M.D. Hemant Pawar, Ph.D. Venkat N. Reddy, Ph.D. Bradley W. Taylor, O.D., M.P.H. Adrienne L. West, M.D. Rebecca A. Wu, M.D. Beverly M. Yashar, Ph.D.

We are pleased to be ranked among the top hospitals in the nation for Ophthalmology in the 2007 U.S.News & World Report survey.

Rajani Aatre-Keshavamurthy, Cynthia Abejuro, C.O.M.T., James Adams, M.D., Omar Ahmad, M.D., Lauri Allis, Scott Almburg, Tanya Andrzejewski, Steven Archer, M.D., Robert Arends, M.D., Kristen Atwell, Katherine Augustaitis, Radha Ayyagari, Ph.D., Theresa Banas, Sheryl Bates, Wendy Beeker, C.O.A., Melissa Bergeron, C.O.A., Michael Bergiel, Aimee Bergquist, Terry Bergstrom, M.D., Christine Beser, R.N., Donald Beser, M.D., Zong-Mei Bian, M.D., Susan Bistrow, C.O.A., Renee Blosser, C.O.M.T., Christopher Boehlke, M.D., Sharon Boyk, C.O.T., Ruth Brakoniecki, C.O.T., Kari Branham, M.S., Michael Breider, Matthew Brooks, Deborah Brown, C.O.T., Rebecca Brown, Rose Bugis, Lisa Burke, Lisa Burkhart-Hunt, Jennifer Burkheiser, Jennifer Burrows, Amy Butala, Nicolle Campbell, Patricia Carbary, Caitlin Cashin, Murthy Chavali, Lianchun Chen, Hong Cheng, M.D. Ph.D., Deborah Chong, M.D., Carrie Chrisman-McClure, Jared Chrispell, Linda Cirenza, Andrea Clark, Julie Clay, Laurie Clayton, Radu Cojocaru, Ph.D., Jennifer Cole, Grant Comer, M.D., P. Conrad, M.D., Theresa Cooney, M.D., Wayne Cornblath, M.D., Deborah Cox, Sonya Craig, Ph.D., Tiffany Craig-Buers, C.O.A., Christine Crilly, MargaretAnn Cross, Cathy Culver, Larisa Czabaniuk, Debra Darragh, Hermalinda Davis, C.O.M.T., Ruth Davis, Virginia Davis, Sherry Day, O.D., Janet Deja, Monte Del Monte, M.D., Jonathan Demb, Ph.D., Matthew Demeester, Gayle Dickerson, Trinity Dobson, Gregory Dootz, Leslie Dudderar, Robert Duerr, Donna Duffy, Casandra Dunham, Deborah Eadie, Maya EibschitzTsimhoni, M.D., Neddou El-Awar, Carolyn (Cara) Elmer, Susan Elner M.D., Victor Elner, M.D., Ph.D, Karen Elve, C.O.T., Zachary Ernst, Alejandro Estrada Cuzcano, Marilouise Fall, Kecia Feathers, Sharyn Ferrara, Kelly Ferrentz, Elena Filippova, M.D., Jerome Finkelstein, M.D., Leigh Flagel, Gretchen Ford, C.O.T., Linda Fournier, C.O.A., James Friedman, Ph.D., Muriel Fritz, Bartley Frueh, M.D., Cynthia Furca, Bruce Furr, C.O., Philip Gage, Ph.D., Alberto Ruiz Galvez, M.D., Beverly Gauthier, Amy Geering, Hume Getchell, Teresa Gibbons, C.O.A., Mitchell Gillett, Courtney Godfrey, Linda Goings,C.R.A., Robert Goldsmith, M.D., Julie Gothrup, C.O.A., Hilary Grabe, M.D., Daniel Green, Ph.D., Jill Green, M.D., Richard Hackel, C.R.A., Edward Hall, M.D., Ying (Lisa) Han, M.D., Hong Hao, Adam Hassan, M.D., Shirley He, John Heckenlively, M.D., Peter Hitchcock, Ph.D., Daphne Hoffman, Jackielee Hoffman-Kurish, C.O.A., Marian Hoppes, C.O.A., Linda Hosman, Jibiao Huang, Ph.D., Catherine Huebner, C.O.A., Bret Hughes, Ph.D., Theresa Hunt, Tony Huynh, M.D., Ida Iacobucci, C.O., Marilyn Irwin, Eisuke Ishizaki, M.D., Ellinor Israel, Diane Jacobi, O.D., Shaylynn Jean, Laurie Jessup, C.O.M.T., Jamie Jett, Lin Jia, Kathy Johnson, Mark Johnson, M.D., Diane Jones, Ning-Ju Juang, Laura Kakuk-Atkins, Roheena Kamyar, M.D., Atsuhiro Kanda, Ph.D., Athanasios (AJ) Karoukis, Harjeet Kaur, M.D., Naheed Khan, Ph.D., Hemant Khanna, Ph.D., Ritu Khanna, Bethany Kimlin, James Knaggs, M.D., Piyush Kothary, Ph.D., Sharon Kotus, L. (Cathy) Kowalak, C.O.A., Charles Krafchak, Mary Ann Krolczyk, Jennifer Kromrei, Sharon Kruse, Tabitha Kucka, Jennifer Kuzminski, Deborah Langrill Beaudoin, Ph.D., Yvonne Leonard, Helios Leung, O.D., Ph.D., Thellea Leveque, M.D., M.P.H., Erika Levin, M.D., Mark Lewis, Ph.D., Paul Lichter, M.D., Austra Liepa, Laurie Linton-Miller, Donna Lipke Michael Lipson, O.D., Ying Lu, M.D., Ph.D., Susan Ludwig, Erin Manno, A.S., C.O.A., Michael Manookin, Edward Margolin, M.D., Velma Markins, DaNita Martin, Yvonne Mason, Diana Mathis, Tanya McClendon-Hubbard, C.O.A., Carrie McIntyre, Kathleen Meyer, Shahzad Mian, M.D., Barbara Michael, C.O.T., Helen Moore, Sayoko Moroi, M.D., Ph.D., Patricia Moses, Alison Murchie, Carlos Murga, David Murrel, David Musch, Ph.D., Christine Nelson, M.D., Tammy Nguyen-Reifler, Betsy Nisbet, Leslie Niziol, Cynthia Noland, Omondi Nyong’o, M.D., Brian O’Keefe, Nancy Oberlin, Margaret Ochocinska, Edwin Oh, Gale Oren, Kathy (Skip) Osterberg, Mohammad Othman, Ph.D., Jeanette Ouellette, Jill Oversier, Sunil Parapuram, Ph.D., Seung Park, Jared Parker, M.D., Emily Parus, Jennifer Patrick, Bikash Pattnaik, Ph.D., Margaret (Peg) Pennington, Penny Persinger, Howard Petty, Ph.D., Laura Pfleger, B.S, Jean Pietrzak, Sheryl Podlewski, A.S., Carol (CJ) Pollack-Rundle, C.O.M.T., Cindy Pope, C.O.A., Jonathan Pribila. M.D., Ph.D., Mireille Prusak, Robert Prusak, C.R.A., Donald Puro, M.D., Ph.D, Min Qian, Paulina Radenbaugh, Linda Raser, Tamera Reames, Stephen Reck, M.D., Venkat Reddy, Ph.D., David Reed, Ph.D., Margarete Ribianszky, Richard Rice, Julia Richards, Ph.D., Christopher Rodarte, M.D., Jerome Roger, Ph.D., Shawn Ronan, M.D., Jodi Rosa C.O.A., Frank Rozsa, Ph.D., James Salisbury, O.T.R., Shannan Saltz, Jennifer Samples, Gary Sandall, M.D., Mary Kay Sarazin, Hilary Savage, Stephen Saxe, M.D., Dwight Scales, Perry Schechtman, Tara Schmitt, Ronald Schmit, Karen Schneider, Nancy Schneider, Kai-lyn Schroeder, Garret Scott, M.D., Kathleen Scott, Roni Shtein, M.D., Cindy Siegel, Susan Simpson, Deanna Sizemore, C.O.A., Justin Skrzynski, Ron Slocumb, M.D., Dannielle Smail, Camille Smith, Dianna Smith, Jeanne Smith, Michael Smith-Wheelock, M.D., Marty Soehnlen, H. Kaz Soong, M.D., Michelle Sovel, C.O.T., C.O.S.T., Phyllis Spencer, Roslyn Stahl, M.D., Carol Standardi, R.N., Kimberly Starnes, Amy Steele, C.O.T., Brendan Stern, Amy Stheiner, Mary Katherine Stringer, Bradley Strong, M.D., Alan Sugar M.D., Anuradha Swaminathan, Anand Swaroop, Ph.D., Scott Szalay, Alexander Taich, M.D., Amit Tandon, M.D., Kristina Tarrant, Bradley Taylor, O.D., M.P.H., Laurie Taylor, Patricia Taylor, Joanne Teall-Timlin, C.O.T., Michelle Tehranisa, C.O.T., Nicole Thomas, Debra Thompson, Ph.D., Matthew Thompson, M.D., Susan Thoms, M.D., Pamela Titus C.O.T,, Patricia Tongusi, Edward Trager, Jonathan Trobe, M.D., Daiva Turuta, Pornchanok Udomlapsakul, Mary Jo Ulrich, Therese Van Heck, C.O.T., Sylvester Van Horn, Jr., Vidyullatha Vasireddy, Ph.D., Andrew Vine, M.D., Susan Vitous, Michael Wade, Randall Wallach, Trevin Wallin, M.D., Shirley Wargo, Jennifer Weizer, M.D., Linda Weller, Megan Wellman, C.O.A., Adrienne West, M.D., Molly Wheaton, Alyce Whipp M.P.H., Margaret (Peg) White, Katherine Whitney, Donna Wicker, O.D., Diana Williams, John Williams, Julie Willis, C.O.A., L.P.N., Stacey Willis, June Wilson, Kim Wisniewski, N.C.L.E., Abigail Woodroffe, David Wu, M.D., Ph.D., Rebecca Wu, M.D., Dongli Yang, M.D., Ph.D., Jingyu Yao, M.D., Hawke Yoon, M.D., Jindan Yu, David Zacks, M.D., Ph.D., Jia Xin Zhang, Xiaoming Zhang, Qiong-Duan (Jean) Zheng, Aiping Zhu, Ph.D., Dongxiao Zhu, Ph.D., Jennifer Ziehm-Scott, C.O.A., Marsha Zielinski

U-M kellogg eye center 2007 annual Report

Executive Officers of the University of Michigan Health System

For additional copies of this report,

Robert P. Kelch, M.D.

please contact us at:

Executive Vice President for Medical Affairs Douglas L. Strong, M.B.A.

University of Michigan

Director and CEO, University of Michigan Hospitals and Health Centers

Department of Ophthalmology

James O. Woolliscroft, M.D.

and Visual Sciences

Dean, University of Michigan Medical School

W.K. Kellogg Eye Center

The Regents of the University of Michigan

1000 Wall Street Ann Arbor, Michigan 48105

Julia Donovan Darlow, Ann Arbor; Laurence B. Deitch, Bingham Farms; Olivia P. Maynard, Goodrich; Rebecca McGowan, Ann Arbor;

734.763.1415

Andrea Fischer Newman, Ann Arbor; Andrew C. Richner, Grosse Pointe Park;

www.kellogg.umich.edu

S. Martin Taylor, Grosse Pointe Farms; Katherine E. White, Ann Arbor; Mary Sue Coleman, Ph.D., ex officio