Shaping future leaders in science and innovation, this exciting programme has kicked off with a bang!
Advancing Global AI and Human Rights Framework at the School for Data Sciences and Computational Thinking.
A strategic trip to the U.K., ten meetings with funders, philanthropists, scientific leaders, and businesses.
The launch of the African STARS Fellowship, bringing together young scientists from across Africa for intensive training in genomics, innovation, and leadership, kicked off with a bang. The opening dinner at STIAS featured a fun and interactive drumming session.
During the African STARS Fellowship’s Media & Communication Training, fellows learnt how to distil their science, strip away technicalities and jargon, and present it so that every stakeholder can clearly grasp its relevance and impact.
We spoke with four fellows from the CERI cohort, who all emphasised how the programme equips them with skills, perspectives, and confidence to make their research relevant beyond academic journals into the world of fund raising, innovation and commercialisation.
the gem: Centre for Epidemic Response and Innovation (CERI) & South African Centre for Epidemiology and Modelling Analysis (SACEMA), Stellenbosch University & KwaZulu-Natal Research, Innovation and Sequencing Platform (KRISP), UKZN, Durban director: Tulio de Oliveira editors: Tulio de Oliveira and Katrine Anker-Nilssen art director: Victor Hugo Szortyka graphic designers: Maambele Khosa, Ronison Guimaraes, Tulio de Oliveira, Katrine Anker-Nilssen printers: Gwynneth Louw websites: https://ceri.org.za/ https://www.krisp.org.za/, https://www.sacema.org/
Wellcome-funded WEMA project leaders at CERI, Dr Astrid TreffryGoatley and Dr Gill Black facilitate, five-day digital story telling workshops in collabortion with local community engagement specialists, to equip participants with skills in scriptwriting, image creation, voice recording and basic digital editing.
The Policy Innovation Lab, through the School for Data Science and Computational Thinking at Stellenbosch University, recently participated in a high-level dialogue on Artificial Intelligence (AI) and human rights. The event brought together leading voices from academia and government.
We recently completed a strategic trip to the U.K., holding ten meetings with funders, philanthropists, scientific leaders, and businesses to support CERI’s research, innovation, and training activities.
This past month has been exceptional! We are proud to announce the launch of the African STARS Fellowship programme, a milestone for Africa. Our first call attracted over 3 000 applicants for just 40 fellowships, which was an extraordinary response that highlights Africa’s scientific talent.
A 12-member selection committee from CERI, KRISP, and Institut Pasteur de Dakar carefully reviewed candidates. The first 20 fellows, now in Stellenbosch, have impressed us with their passion and brilliance. This edition of the gem celebrates the program’s launch in South Africa; the next will highlight the fellows starting in Dakar, Senegal.
We also feature our work with communities most affected by climate change, which is a driver of epidemics, displacement, and mental health challenges. Dr Astrid Treffry-Goatley and Dr Gill Black share how digital storytelling workshops in Kenya, Burkina Faso, and Mozambique are equipping participants to create and share their own stories. These narratives are helping guide policymakers and public health officials to respond to climate-related health issues.
Capacity building remains central to our mission. KRISP recently hosted the international Ensembl Training Workshop at UKZN, sponsored by DIPLOMICS, to strengthen skills in bioinformatics and genomics. We also joined the UKZN College of Health Sciences Annual Research Symposium, where KRISP postgraduate students presented their innovative work.
Our collaborations extend beyond South Africa. Ugandan PhD researcher Isaac Omara trained at ILRI in Nairobi, gaining expertise in structural biology tools such as AlphaFold, PyMol, and ChimeraX. Together, we are advancing vaccine research for animals and humans to help prevent future pandemics.
Finally, a senior CERI delegation traveled to the U.K., meeting funders, philanthropists, and scientific leaders to expand support for our research, innovation, and training programs.
With spring arriving in South Africa, this month reminds us of the power of growth and renewal, not just in nature, but in science and opportunity. The energy of our fellows, the courage of communities, and the dedication of our teams inspire us every day. We are proud to nurture talent, build capacity, and advance science that will shape a healthier, stronger Africa for generations to come.
text: Tulio de Oliveira
The African STARS Fellowship Programme is a pioneering initiative designed to empower young African scientists through intensive training in genomics, innovation, and leadership.
text: Maambele Khosa photos: Ignus Dreyer
Stellenbosch University has launched the African STARS Fellowship Programme, bringing together young scientists from across Africa for intensive training in genomics, innovation, and leadership. The initiative aims to build the next generation of leaders equipped to tackle the continent’s public health challenges with local solutions and global impact.
Africa faces some of the world’s most pressing public health challenges, from infectious disease outbreaks to antimicrobial resistance and limited access to life-saving vaccines. Yet the continent also holds immense scientific talent, innovation potential, and unique local knowledge.
On Monday 18 August, Stellenbosch University welcomed the first cohort of the African STARS Fellowship Programme, marking the start of a transformative journey for talented scientists hailing from across the continent. Fellows from Cameroon, Egypt, Ethiopia, Eswatini, the Democratic Republic of Congo, Egypt, Ghana, Kenya, Malawi, Morocco, Nigeria, Tanzania,
Tunisia, Uganda, Zimbabwe and South Africa arrived in Stellenbosch over the weekend, ready to embark on intensive training and collaboration that will shape the future of science, health, and innovation in Africa.
The African STARS Fellowship is built on the principle that African challenges require African solutions, harnessing the strengths, creativity, and expertise within Africa to pioneer research and innovation that serve its people and contribute to global health.
The opening ceremony was marked by words of encouragement from Prof Tulio de Oliveira, Director of the Centre for Epidemic Response and Innovation (CERI) at Stellenbosch University, who said: “The African STARS Fellowship programme is about building the next generation of African scientists, innovators, and leaders who will not only transform their communities but also shape global health.”
The fellowship offers four programmes, of which two are ATT and YPP. The Advanced and Translational Training (ATT) Fellowship provides four months of immersive,
analysis, genomic diagnostic design, and vaccine manufacturing. Alongside technical training, fellows gain leadership skills such as grants and financial management, team management, and leadership development. The Young Professional Programme (YPP) Fellowship, designed for Africa’s next generation of science leaders, span 12 months with four tracks: research management, innovation and entrepreneurship, infectious disease R&D for diagnostics, and innovations to enhance patient outcomes.
Prof Sibusiso Moyo, Deputy Vice-Chancellor for Research, Innovation and Postgraduate Studies, emphasised the significance of the fellowship: “Your work is not only scientifically vital but deeply impactful for communities across Africa. We look forward to learning with you, witnessing your contributions, and using your success to expand opportunities for future fellows.”
Sarah Van der Westhuizen, Director for Global Engagement, highlighted the importance of building bridges beyond borders: “This fellowship is more than just training; it’s about creating a network of African scientists and as Stellenbosch University International, we are proud to provide support to the African STARS Fellowship Programme ; we believe that this initiative will have a lasting impact on the African continent.”
The Opening Ceremony included an energetic drumming session, a fun dancing competition, and a great atmosphere allowing the fellows to network, get to know each other, and the SU/CERI team better.
From Egypt, Salma Wagih Yakoub Elsayed, a researcher specialising in microbial genomics, resistance, and virulence, expressed her motivation: “I am particularly interested in vaccines, but also excited to gain experience in other aspects of science. My biggest goal for the African STARS Fellowship is to take home new knowledge to share with my lab back home.”
From Ethiopia, Kajelcha Fikadu Tufa, whose research focuses on antimicrobial resistance, biomanufacturing, and One Health, reflected: “My passion is AMR, but I am looking forward to learning more from both other fellows and facilitators through this programme. I want to gain more knowledge about developing vaccines, and take this knowledge home to Ethiopia – sharing it with fellow scientists in my home country.”
From Morocco, Laila Oulad Belayachi, a PhD candidate in molecular biology and microbiology, shared her enthusiasm: “I am excited to gain more knowledge and expertise within science – learning the best from the best. And I can’t wait to enjoy more of the cultural diversity South Africa offers.”
With its holistic approach, blending advanced scientific training, leadership development, and entrepreneurial skills, the African STARS Fellowship promises to produce a new generation of leaders equipped to tackle Africa’s most pressing health and innovation challenges.
For a full introduction to all the Fellows, and to read more about the Afircan STARS Fellowship, please visit: https://www.starsfellows.africa/star-fellows/
“The African STARS Fellowship programme is about building the next generation of African scientists, innovators, and leaders who will not only transform their communities but also shape global health.”
- Professor Tulio de Oliveira
You’re invited to join innovators, entrepreneurs, researchers, investors, and healthcare leaders for the inaugural Cape HealthTech Connect –a unique platform designed to bring together the people and ideas shaping the future of health technology in the Western Cape. Hosted by Stellenbosch Network, Stellenbosch University LaunchLab, and the Centre for Epidemic Response and Innovation (CERI), this gathering will explore opportunities to bridge the gap between cutting-edge research, local manufacturing, and the realities of healthcare delivery. Expect insightful discussions on innovation pathways and market readiness, curated networking sessions with key players in the health innovation ecosystem, opportunities to collaborate and accelerate impactful solutions, and exciting exhibitions from startups.
Click HERE to reserve your seat!
Transformative Leadership Training
Empowers African STARS Fellows
Apart of the African STARS Fellowship Programme, the Leadership and Core Skills Training Week prompted fellows to step outside their comfort zones and enhance their selfconfidence. Held from August 25-29, the week focused on essential leadership topics –including leadership identity, emotional intelligence, resilience, mentoring, accountability, and growth mindset. Fellows engaged in group discussions and practical exercises, culminating in individual pitches at the end of the week.
The opening sessions invited fellows to reflect on their leadership identities, drawing from diverse personal and professional experiences in research, entrepreneurship, and community engagement. “This diversity greatly enriched our discussions on the role of leadership and the values of effective leaders,” said Prof Lenine Liebenberg, the week’s coordinator. Co-facilitator Dr Bethlehem Tefera added that fellows openly examined how their
unique experiences shaped both their strengths and challenges in how they lead. “They discussed them boldly, and used the session to navigate and deepen their understanding of their leadership identity,” she noted.
Building on this foundation, Mrs Lewin Moodley introduced Emotional Intelligence (EI). Fellows explored tools such as selfawareness, self-regulation, and the ABCDE model. “These do not take root immediately but deepen through mindfulness and interaction,” she explained. By midweek, fellows were already applying EI principles in practice. “Conversations became more reflective, psychological safety increased, and collaboration strengthened,” noted Lewin. “The fellows could readily articulate how they had grown and how their perspectives had changed –reinforcing the fact that Emotional Intelligence is not a one-time lesson but a continuous practice.”
The programme also featured a keynote by Prof Kanshu Rajaratnam, who shared his journey from engineering to finance to leading the School for
LEFT: African STARS fellows
Celestine Kemunto Nyamari and Kajelcha Fikadu Tufa.
RIGHT: Prof Lenine Liebenberg with fellow Laila Oulad Belayachi.
Data Science at Stellenbosch University, set against financial uncertainties, geographic changes, political turmoil and a global pandemic. Despite many context-specific strategies, his central theme of connection resonated most. “He emphasised that collaboration and trust foster resilience, innovation, and impactful change,” said Lenine. Inspired, one fellow reflected: “I aspire to be a collaborative leader… empathetic but firm.”
Later in the week, Lenine reframed mentorship as reciprocal, rooted in accountability and trust, and supported by a mentorship agreement template. Lewin complemented this with her own story of reframing failure as growth, encouraging fellows to adopt a mindset where setbacks fuel resilience. In the Accountability Session, this perspective prompted a shift from blame to ownership, with fellows leaving “more mature and action-oriented.”
The focus then turned to entrepreneurial leadership. Dr Yaw Bediako stressed the role of entrepreneurial scientists in
linking research and innovation for Africa’s development, a theme expanded by Dr Anton du Preez van Staden, who shared practical strategies from his own journey. Fellows embraced the complementarity of science and entrepreneurship in health innovation.
The week concluded with Capstone presentations, in which fellows described their identities as leaders – including their values, their strengths, and their purpose. “They noted specific challenges that hamper their goal attainment, and set out an action plan for progress within the next 6-12 months – committed to holding themselves and their peers accountable for these action plans that translate their new skills into action,” explained Lenine. “These presentations were a living demonstration of leader development,” she continued. Many described the week as transformative, noting the power of introspection in shaping leadership identity.
Overall, the programme equipped fellows with the mindset, skills, and confidence to lead in African science. “Their reflections echo the programme’s aims: fellows left inspired, accountable, and committed to building resilient teams, institutions, and innovations that serve Africa’s future,” concluded Lenine.
Sawra Abdesselem
We often imagine leadership as a single person embodying values and styles, putting leaders on a pedestal while absolving ourselves of responsibility. During Leadership Week at the African STARS Fellowship, I learnt to see leadership not as an individual but as a framework that guides institutions and communities. Leaders are catalysts—like parents, they don’t always choose their team but show up daily with care, guiding others to succeed. Leadership is less about authority and more about supporting those in your care.
Leadership Week was transformative. I arrived thinking leadership was about authority but learnt it is dynamic, requiring agility, foresight, and collaboration. Team simulations taught me adaptability, while mentorship sessions reframed mentorship as a reciprocal, authentic exchange. Embracing a growth mindset helped me see setbacks as opportunities. I left inspired, with a clear leadership roadmap to strengthen my skills, navigate challenges, and impact my institution and community. I am grateful to the facilitators and proud to be part of this Africa STARS Fellowship cohort.
“Leaders are catalysts –like parents, they don’t always choose their team but show up daily with care, guiding others to succeed.”
–
Sawra Abdesselem, African STARS Fellow Alex Durand
text: Katrine Anker-Nilssen photo: Maambele Khosa
Science that is not communicated effectively can be misinterpreted, overlooked, or even distrusted – particularly in contexts where misinformation thrives. In a world increasingly shaped by science and technology, scientists and leaders have a responsibility to communicate their work clearly, ethically, and inclusively.
The first week of September, Media & Communication Week, equipped African STARS fellows with practical tools to engage with the public, policymakers, media professionals, and other non-scientific communities. “In Africa, we are producing world-class science, but we still have work to do when it comes to investing in how that science is communicated. Breakthroughs only matter if people can understand and act on them,” explained coordinator, Maambele Khosa.
“I’m grateful to have curated and collaborated with experts to equip the African STARS fellows with realworld communication skills, stepping into studios, learning media engagement, practicing photography, and refining their ability to tell stories that matter.”
Alongside this practical training, fellows explored the essence of science communication, why it matters, how to write for the public, and the importance of platforms like The Conversation Africa.
Facilitator Katherine Rabik, with colleagues Marina Joubert and Lili Rademan, opened the week with a science communication workshop. “After setting the scene with a discussion about the history, theory and ethics of science communication, we guided the fellows through the process of creating an impactful science communication presentation by considering the audience, jargon, structure and public speaking skills,” explained Katherine. “At the end of the day we were truly blown away by the amazing presentations the fellows created, and can’t wait to see what else they accomplish over the course of the fellowship.”
For fellow Francisca Serwaa Adomako, the experience was life-changing. “I often struggle to engage, and to get my message across. As a scientist, I have shied away from media and communication. Convincing myself that the lab is my turf, that I don’t belong in front of cameras or behind desks writing pieces to the media,” she said. “However, this week has transformed that thinking. I have learnt that communication is the true currency
of science, and that there is no one better qualified to carry the message of our work than we, the scientists.”
Francisca thanked the facilitators – Maambele Khosa, Prof Tulio de Oliveira, Prof Marina Joubert, Dr Lili Rademan, Katherine Rabik, Martin Viljoen, Stefan Els, and Prof Sibusiso Moyo – for opening her eyes to the power of clear communication. “We learned how to distil our science, strip away technicalities and jargon we so often take for granted, and present it so that every stakeholder can clearly grasp its relevance and impact.” She also acknowledged The Conversation Africa team, Caroline Southey and Kagure Gacheche, for guidance on pitching and shaping articles.
The week concluded with a photoshoot and sessions on marketing and personal branding, led by Prof Chris Pentz and Dr Debbie Human-Van Eck. “Five days of practical, engaging learning and rich insights have been nothing short of transformative,” said Francisca. “There is no ‘better’ person out there to communicate your science. Go for it!”
Maambele summed it up: “Problem-solving isn’t just about discoveries, it’s about how those discoveries are shared with the world. If we expect scientists to engage with the public, policymakers, and the media, we must equip them with the tools, training, and confidence to do so effectively.”
In just weeks, fellows from across the continent have already engaged in leadership, science communication, and innovation training.
text: Katrine Anker-Nilssen
photos: Stefan Els
The African STARS Fellowship is cultivating a new generation of leaders committed to translating research into impactful solutions for Africa.
In just weeks, fellows from across the continent have engaged in leadership, science communication, and innovation training, forming networks that transcend disciplines and borders. Their reflections underscore a shared commitment to tackling challenges in public health, biotechnology, and local manufacturing.
We spoke with four fellows from the CERI cohort, who all emphasised how the programme equips them with skills, perspectives, and confidence to make their research relevant beyond academic journals. What motivated them to apply, and how do they feel about the programme so far?
Celestine Kemunto Nyamari from Kenya, a molecular biologist and public health researcher, shared, “I wanted to bridge the gap between science and practical solutions for public health. This fellowship has already reshaped my identity as a researcher, emphasising leadership, mentorship, and impactful communication, empowering me to inspire real change across Africa.”
South African multilingual biomedical scientist, Charleen Wormsberg ,applied to the fellowship because she felt the need to contribute to something greater. “I was drawn to this programme’s vision of integrating science and entrepreneurship. The fellowship fast-tracks skills scientists often miss, reshaping my outlook on science’s impact.”
Kennedy Mulungu, a young Malawian biomedical scientist, expressed his motivation to develop local biomanufacturing capabilities. “This fellowship provides world-class skills in
vaccine design and diagnostics, empowering me to address our health challenges and contribute to building resilience in Malawi.”
Kingstone Nihaka from Zimbabwe, a co-founder of a biotech startup who is passionate about democratising biotechnology, noted, “The first three weeks have been transformative. The fellowship has fostered networking, leadership conversations, and a journey of unlearning and relearning that empowers our vision for Africanled solutions.”
The African STARS Fellowship strives to improve African capabilities in genomics, diagnostics, and vaccine manufacturing while strengthening the African health workforce in response to future epidemics. Through this exciting fellowship, there’s no doubt that these emerging young leaders are poised to make a lasting impact on the continent’s future.
“I aim to use the skills this programme equip me with to empower communities by making science accessible and impactful, ensuring that everyone has an equal chance to thrive.”
– Charleen Wormsberg, African STARS Fellow
My journey in the African STARS Fellowship has been enriching in many respects. One standout experience was the session on Personal Values and Vision Mapping led by Dr Mothomang Diaho. It encouraged deep reflection on the “why” behind our scientific endeavors and leadership aspirations. Through this self-discovery process, I identified my core values — integrity, family, and personal growth — which now serve as my guiding compass in both my scientific and entrepreneurial pursuits.
The media and communication sessions were equally pivotal. I learnt that effective communication is not merely a soft skill but a fundamental necessity in shaping science and its societal impact. Real-world exercises, including TV interviews and photography, equipped me with skills needed to engage confidently with diverse stakeholders — essential for a biotech entrepreneur like me, advocating for a bioeconomy in Africa.
Networking has played an integral role in my experience as well. Collaborating with talented fellow African STARS has fostered invaluable relationships across various domains, including genomics and epidemiology. We’ve even enjoyed time together on
the soccer field, strengthening our bonds beyond academia and professional discussions. Playing soccer with my peers has not only provided a refreshing break from our intense training but also helps solidify our camaraderie and teamwork skills.
I envision this fellowship as a crucial stepping stone, equipping me with the skills, confidence, and connections I need to drive biotech innovation through my company, Plasmigene, ultimately benefiting the communities I aim to serve.
One of the most memorable experiences I had during the first three weeks was sitting in a discussion circle with fellow scientists from different countries. We shared the health challenges and triumphs we face, reminding me that while our contexts vary, our mission is the same: to create solutions that meet Africa’s needs through collaboration.
This fellowship has expanded my perspective, revealing how interconnected our health challenges are, and highlighting the importance of sharing knowledge. I’ve already gained valuable skills in public speaking, enabling me to communicate my research clearly, which I believe will empower me to shape impactful public health solutions across Africa.
During the first weeks, I was deeply inspired by Prof Tulio de Oliveira’s powerful opening remarks, which emphasised that this programme is about nurturing future African leaders who will innovate locally.
Meeting my fellow African STARS has also been a highlight, I have connected with brilliant minds from across the continent, learning about their ambitions and experiences.
The training sessions on leadership and communication helped me gain deeper selfawareness and crucial skills for influencing and engaging the public in science. I realised the pressing health challenges we face in Malawi, and this fellowship is equipping me to address them through innovation in diagnostics and vaccines.
Networking has been invaluable; I’ve engaged with peers tackling similar health issues, leading to exciting collaborative discussions. My advice to future fellows is to embrace this opportunity as a launchpad for impactful solutions that shape Africa’s future.
One of the most memorable moments for me during the first three weeks was hearing Kennedy share his inspiring journey from a farming background with no cellular network, to becoming an African STARS fellow. His story made me reflect on the struggles faced by each fellow, and the opportunities that can change lives. This experience deepened my gratitude for my own opportunities and heightened my awareness of the necessity to create equality for others.
The fellowship has also transformed my understanding of global health challenges, revealing their intricate ties to politics and economics. I now see how crucial it is to navigate these systems to enact real change.
So far, the programme has equipped me with invaluable skills in leadership and communication, which I aim to use not only to advance my career but also to empower communities by making science accessible and impactful, ensuring that everyone has an equal chance to thrive.
text:
Dr Chanelle Mulopo and Dr Astrid Treffry-Goatley photo: supplied
Climate change is accelerating the frequency and severity of extreme weather events — heatwaves, floods, and droughts — with devastating consequences for already vulnerable populations in sub-Saharan Africa. These events disproportionately affect communities in resource-poor settings where the burdens of illness, poverty, and infrastructural limitations are high. Yet among the wide-ranging health impacts of climate crises, the mental health consequences remain underexplored.
The WEMA (The Impact of Extreme Weather Events on the Mental Health of Vulnerable Populations in Africa) project seeks to address this evidence gap. Our focus is the direct impact of extreme weather events (EWEs) on the development of common mental disorders (CMDs)—such as depression, anxiety, and posttraumatic stress—amongst vulnerable populations in Burkina Faso, Kenya, Mozambique, and South Africa.
A transdisciplinary team has formed to tackle this complex task, including climate scientists, psychiatrists, epidemiologists, statisticians, data scientists, social scientists, civil society leaders, engaged research specialists, media professionals and affected community members.
Too often, climate research relies on top-down models that exclude the everyday realities of those most
affected. WEMA challenges this approach by positioning lived experience as expert knowledge. By engaging affected individuals as equal partners in research, we promote inclusion, disrupt extractive research practices, and create space for new insights to emerge.
One of our key participatory methods is Digital Storytelling (DST). This data-generation process enables individuals to create short multimedia videos that reflect their personal experiences. In WEMA, DST will be used to generate community-authored data and make visible the nuanced, often-overlooked mental health impacts of EWEs.
At each site, Dr Astrid Treffry-Goatley and Dr Gill Black are facilitating five-day DST workshops in collaboration with local community engagement specialists. These workshops equip participants with skills in scriptwriting, image creation, voice recording and basic digital editing. Dr Chanelle Mulopo is a postdoctoral research fellow on the WEMA project. She oversees the day-to-day operations and will be leading aspects of the analysis from the DST workshops.
To date, we have conducted DST workshops in two locations: Nairobi, Kenya, and Durban, South Africa. In both sites, communities had recently experienced severe flooding. A total of 18 community-based coresearchers, men and women over the age of 18, participated. Each created a unique digital story reflecting on how a personal experience of flooding
disrupted their homes, families, and affected their mental health. In Kenya, psychologist Simione was present throughout the workshop to provide psychological support. In Durban, Samke, a registered social worker, ensured the well-being of participants. This emphasis on mental health support was critical, given the emotional weight of revisiting traumatic events. As one CBCR reflected: “I have never shared what happened to us during the floods with anyone.”
The DST process has been transformative, not only for participants but for the research team. Crucially, these participatory methods reposition community members as co-owners of the research. Their insights deepen our understanding of how people make sense of climate change, how they cope, and what support systems are—or are not—available.
As one participant expressed: “We are very happy that you came here, spent time with us, and listened to how the floods impacted us.”
To watch participant Ashford Salim’s digital story, created during the Kenya workshop, follow this link
This work would not have been possible without the dedication and care of our community engagement teams, their work in preparing communities and supporting the DST workshops was essential to the success of this research. From Kenya (African Population and Health Research Center): Lucy Akinyi and Henry Owoko Odero. From South Africa (Africa Health Research Institute): Ruth Mthembu, Dr Sithembiso Ndlovu, and Luthando Zuma.
ABOVE: Kenya DST workshop, 12-16 May 2025. BELOW: DST Workshop Structure/Daily Activities.
text: Paul Harris
photo: Paul Harris
August in South Africa is a time to reflect on the resilience, strength, and achievements of women. At KRISP, we are especially proud to celebrate the incredible women who make up the majority of our team. These dynamic leaders, scientists, and innovators drive our genomic research forward, shaping the future of public health and strengthening our mission of excellence in science.
This Women’s Month, we took the opportunity not only to recognise their invaluable contributions but also to create space for rest, reflection, and well-being. On a bright Durban morning, members of the KRISP team stepped away from the demands of the laboratory to enjoy a rejuvenating yoga and meditation session on the beachfront, followed by a relaxed and joyful ladies’ brunch. The day was a reminder that nurturing one’s mental and emotional well-being is just as important as professional growth. Creating these moments of balance allows our team to return to their work with
renewed energy and focus – ready to continue pushing boundaries in genomics and public health.
Some of our team members shared encouraging words and inspiring quotes around what Women’s Month means to them:
“When women lead, change follows.” - Dr Maryam Fish “Know your WHY and watch how purpose drives change.” - Hlengiwe Shange
“Nothing is as important as taking your space and cementing yourself.” - Mulalo Raphalalani
“There is no limit to what we, as women, can accomplish.” - Thembelihle Tombo
At KRISP, we remain committed to fostering diversity, inclusion, and empowerment in science. We know that when women are encouraged, supported, and celebrated, the entire research community – and society at large – benefits. Here’s to the inspiring women of KRISP who drive innovation and embody resilience, creativity, and collaboration every day.
text: Robert Gifford and Katrine Anker-Nilssen
What began as Robert Gifford’s small side project – building a database of Adenoassociated viruses (AAV) genomes – soon uncovered a striking pattern: capsid genes appearing in unexpected places. His work revealed that these genes have frequently hopped between lineages, reshaping the evolution of adenoassociated viruses. Beyond rewriting viral history, Robert’s findings also shed light on how this natural “gene swapping” could influence the future of gene therapy. Before we share a link to Robert’s recently published paper, let’s hear more from him about his comprehensive study.
Adeno-associated viruses (AAVs) are small viruses widely used in gene therapy because they can deliver genetic material into cells. Two of their most important genes are rep, which encodes proteins that control virus replication, and cap, which encodes proteins that form the virus’s protective outer shell. Normally, these genes evolve together as the virus and its host species co-diverge over long periods of time. In this study, we found that the cap gene has often been exchanged between different AAV lineages in a process known as horizontal gene transfer. These exchanges have occurred across AAVs infecting many different mammal groups and have played a major role in shaping AAV diversity. “Our analysis combined data from modern viruses and ancient viral DNA sequences preserved in host genomes, giving new insights into how these gene transfers have shaped AAV evolution,” explains Robert.
This is the first comprehensive study to show that AAV capsid genes have spread widely between different viral lineages, independently of their replication genes. These results highlight that AAV genes, while often linked in evolution, can sometimes take very different paths. Understanding how capsid genes move between lineages is important for two reasons: 1. It helps reconstruct the true evolutionary history of AAVs and related viruses.
2. It may have practical implications for gene therapy, where engineered AAV capsids are used to target specific tissues. Knowing the natural “mix-and-match” history of capsids could inform how we design safer, more effective viral vectors.
The work also highlights that some recent capsid swaps may have occurred in laboratory settings, opening new questions about how human activities influence virus evolution.
“This paper grew out of what I thought would be a small side project – building a reference database for AAV genomes,” explains Robert. “But as I looked closer, a surprising pattern emerged: a single capsid lineage turning up in distantly related viruses. That curiosity became the driving force behind months of detective work, using evolutionary analysis to piece together how these capsids spread.”
What excites Robert most is that this work links the deep evolutionary history of viruses with very modern biotechnology. It also shows the value of open, reproducible science: everything from the data to the analysis pipeline is publicly available, so others can test, reuse, and build on it. “I hope it sparks both basic research into viral evolution and thoughtful discussion about how lab practices might unintentionally shape the viruses we study,” says Robert.
Read the fascinating full article here: https://www.pnas.org/doi/full/10.1073/ pnas.2505928122
BELOW: Diagram showing how two virus genes tell different evolutionary stories.
text:
Dr Dirk Brand
photo: Gerd Leonhard/Flickr
The Policy Innovation Lab, through the School for Data Science and Computational Thinking at Stellenbosch University recently participated in a high-level dialogue on Artificial Intelligence (AI) and human rights. The event brought together leading voices from academia and government. Chair of Policy Innovation Lab, Prof Willem Fourie facilitated a panel and was a participant on a panel about centering perspectives from the global south. The Lab’s digital transformation researcher, Dr Gray Manicom, facilitated a panel on sectoral impacts of AI on human rights.
This regional dialogue was held in collaboration with the Institute for Ethics in Artificial Intelligence (IEAI) at the Technical University of Munich. The event built on ongoing international efforts, particularly the Munich Summit on AI and Human Rights, to promote inclusive, rights-based approaches to AI governance. A key outcome of the Munich Summit has been the Munich Convention on AI, Data and Human Rights, a concrete proposal for a UN Convention on AI and Human Rights. This initiative aims to catalyse global discussions toward a binding human rights-based framework for AI.
Scholars from institutions including TUM, LMU, and Stellenbosch University have been instrumental in advancing the Munich Convention draft, which outlines concrete steps toward a binding international
treaty on AI, data, and human rights. Building on the foundational work of the Munich AI and Human Rights Summit, the Convention reflects a multi-stakeholder, transdisciplinary effort to move beyond fragmented soft law approaches and establish an enforceable global standard for AI based on the UN Charter and the Universal Declaration of Human Rights. The recent dialogue in Stellenbosch deepened this process by incorporating critical regional insights and Global South perspectives, addressing the need for global stakeholder representation in global AI governance.
As a response to growing concerns over increasingly fragmented national regulations, the proliferation of voluntary ethical guidelines, and the lack of enforceable safeguards against AI-related human rights harms, the Munich Convention represents a systematic and necessary progression toward global AI governance rooted in international human rights law. Its official presentation to the UN Human Rights Council in Geneva in March 2025 marked a pivotal moment in this process, positioning the Convention as the next logical step for the international community to close governance gaps, harmonize standards, and address the structural risks posed by AI to dignity, equality, and democratic accountability, while ensuring adaptability of regional or in-country context.
The central agenda item was the role of the “Global Majority”, inclusive of nations from the Global South, in shaping international frameworks that govern the development and deployment of AI technologies, ensuring inclusive and equitable governance. The
event was explicitly held in South Africa, as the country has emerged as a significant regional power and has contributed significantly to international debates on decolonization and transitional justice post-Apartheid.
There was broad consensus on the urgent need for a binding global framework on AI and human rights, grounded in the principles of the UN Charter and the Universal Declaration of Human Rights. Such a framework is seen as essential for preventing the deepening of digital inequalities and ensuring that AI technologies serve global public goods rather than entrenching structural disparities and digital divides, which could be reinforced by AI and other digital frontier technologies such as quantum computing.
Participants emphasised the importance of engaging with African Union initiatives and other regional governance structures to ensure meaningful participation of Global South actors in global normsetting processes. This is especially vital for ensuring a holistic understanding of the human rights impacts of AI, including socio-economic, cultural, and political dimensions, within the broader international legal framework.
The discussion highlighted the pressing need to ensure interoperability among national and regional ethical frameworks, with particular attention to the emerging African AI Convention. Harmonizing such standards is viewed as a foundational step toward a coherent global AI architecture that respects cultural pluralism while reinforcing universal rights. This complements the G20’s approach to promote inclusive digital infrastructure and emerging technologies, including AI.
Participants highlighted several urgent priority areas, including the use of AI in healthcare and education, the development of robust impact assessment frameworks, and the standardization of governance tools to ensure accountability, transparency, and the protection of fundamental rights in practice. Additionally, greater efforts are needed to align AI systems deployed in societal contexts, such as large language models, with specific cultural sensitivities, model assumptions aligned with the developmental
conditions in the Global South and inclusive linguistic representation. Major issues discussed included the articulation of digital rights within a binding UN Convention on AI, the recognition of data and human rights (including the right to explainability), the integration of collective rights, the preservation of linguistic diversity, and the promotion of digital literacy. Participants also underscored the urgent need to address global disparities and to establish strong institutional safeguards to ensure that AI development is not only technologically advanced but also equitable, inclusive, and rights-based.
Resources
Whitepaper “Promoting and Advancing Human Rights in Global AI Ecosystems: The Need for a Comprehensive Framework under International Law”
Draft of the Munich Convention on AI, Data and Human Rights
text: Paul Harris photo: Paul Harris
The College of Health Sciences at the University of KwaZulu-Natal hosted its Annual Research Symposium at the K-RITH Tower Building, Nelson R. Mandela School of Medicine, on 25 and 26 August. The event brought together leading scientists, students, and early-career researchers to share cutting-edge research, foster collaboration, and celebrate innovation.
KRISP was proud to be represented by four of our upand-coming researchers, who delivered outstanding oral presentations showcasing the depth and diversity of our work in genomics and public health:
Shirelle Naidoo – Low frequency integrase drug resistance mutations in individuals experiencing virological failure while on dolutegravir-based antiretroviral therapy.
Thembelihle Tombo – Evaluation of a single assay for the surveillance of multiple viral pathogens using Next Generation Sequencing.
Nqobile Mthembu – Adapting the Illumina COVIDSeq for Whole Genome Sequencing of other respiratory viruses in multiple workflows and a single rapid workflow.
Bertha Baye – Molecular Characterization and Phylogenetic Analysis of Dengue Fever Viruses in Côte d’Ivoire.
These presentations highlighted pressing health challenges – from HIV drug resistance to the surveillance of viral pathogens, respiratory virus sequencing, and the molecular epidemiology of dengue. Each researcher demonstrated not only strong scientific expertise but also a commitment to advancing public health through genomics.
The symposium also provided young researchers with the opportunity to network with peers and mentors while competing for prestigious prizes, including funding to present at national and international conferences. Beyond accolades, the experience was invaluable in building confidence and strengthening capacity in Africa’s next generation of scientists.
At KRISP, we are committed to nurturing emerging researchers and providing platforms where their voices, discoveries, and innovations can be shared. We are incredibly proud of Shirelle, Thembelihle, Nqobile, and Bertha for their contributions, and we look forward to seeing their research continue to inspire and impact the scientific community in South Africa and beyond.
text:
Paul Harris
photo: Paul Harris
On the 14th of August, KRISP proudly hosted the Ensembl Training Workshop, part of a nationwide training series sponsored by DIPLOMICS (Distributed Platform in Omics). This initiative forms an important step in strengthening South Africa’s capacity in bioinformatics, data management, and genomics research.
The workshop brought together researchers, postgraduate students, and young scientists eager to expand their skills in genomic data analysis. Through a combination of lectures and hands-on sessions, participants were introduced to the Ensembl platform – a powerful, open-access resource that enables scientists to navigate, analyse, and interpret genomic data with greater ease and accuracy.
The training was expertly facilitated by Dr Aleena Mushtaq Stolworthy and Mhlekazi Molatoli, whose engaging and practical approach created an interactive learning environment. Participants left with not only new technical skills but also the confidence to integrate Ensembl resources into their ongoing and future research.
“Workshops like this are essential to building a strong research community across South Africa and Africa as a whole,” noted Dr Hastings Musopole, one of the participants. “Having access to tools like Ensembl –and knowing how to use them effectively – is a gamechanger for genomic and bioinformatics research.”
At KRISP, we are deeply committed to advancing capacity building, collaboration, and knowledgesharing in genomics. By supporting initiatives like the Ensembl Training Workshop, we continue to empower the next generation of African scientists to harness the full potential of genomic data in tackling pressing health challenges.
We extend our sincere thanks to the facilitators, as well as to DIPLOMICS for sponsoring this important training
initiative. Together, we are building the foundations for a stronger, more connected genomics research community.
What is Ensembl?
Ensembl is an open-access genome browser developed by the European Bioinformatics Institute (EMBL-EBI) and the Wellcome Sanger Institute. It provides researchers with powerful tools to:
• Explore reference genomes for humans and other species.
• Access gene, protein, and variant data.
• Visualise genomic regions and annotations.
• Compare genomes across species.
By offering free, integrated datasets and interactive tools, Ensembl helps scientists worldwide make sense of complex genomic information and apply it to research in health, disease, and evolution.
BELOW: Dr Aleena Mushtaq Stolworthy works one-on-one with participants.
Harnessing Structural Biology to Tackle Global Health Challenges
text: Katrine Anker-Nilssen
photo: Supplied
During his PhD research exchange placement at the International Livestock Research Institute (ILRI) in Nairobi, Kenya, Isaac Omara seized the opportunity to attend an intensive one-week workshop on advanced structural biology and computational modeling. “The training provided me with practical skills in modern computer tools to visualise protein structures, understand highresolution images of them, and test small chemical candidates on proteins for potential drug discovery,” explains Isaac. “It was an eye-opening experience that not only introduced me to protein structural analysis and computational modeling, but also connected me with a vibrant network of African and international scientists committed to tackling pressing health challenges through cutting-edge techniques.”
Isaac gained hands-on experience with advanced structural biology tools such as AlphaFold, PyMol, and ChimeraX – innovative resources that are revolutionising our understanding of proteins and design interventions. “I was particularly excited to see how these techniques could be applied not only to drug discovery, but also to vaccine target validation, which aligns closely with my PhD research on Rift Valley fever virus,” he says.
Acquiring skills in AlphaFold, an advanced AI tool developed by Google DeepMind, was particularly valuable for Isaac. This tool can predict the 3D structure of proteins based solely on their amino acid sequences, which is crucial for understanding protein function and identifying vaccine targets. “Although my PhD primarily featured AlphaFold and PyMol, this workshop enriched my understanding of the evolution of structural biology from experimental methods like X-ray crystallography and Cryo-EM to the emergence of AI-driven tools like AlphaFold,” Isaac notes. “This context clarified how my project fits within the broader scientific narrative and deepened my appreciation of how my work builds on decades of advancements in the field.”
The skills Isaac acquired during the workshop directly enhance his PhD research, which focuses on genomic evolution and vaccine target discovery for Rift Valley fever virus. “My project involves analyzing RVFV genomes from African outbreaks to identify critical mutations and predicting B-cell and T-cell epitopes for potential human vaccine development,” he explains. “The new skills I gained will enable me to model these viral proteins in 3D, offering a clearer perspective on how mutations may influence protein shapes and how epitopes are exposed to the immune system. This structural insight will improve the accuracy of my vaccine target predictions and help me validate them more confidently.”
One of the most challenging aspects of the training was interpreting the complex protein structures after processing them through AlphaFold. “Generating the models was straightforward; however, analysing intricate structural details – such as active sites, binding pockets, or ligands – required critical thinking and guidance from the facilitators,” Isaac elaborates.
By introducing new knowledge and skills in structural biology and protein modeling into CERI’s pathogen genomics work, Isaac adds a vital dimension to research efforts aimed at better understanding viral evolution and identifying potential vaccine targets. This can also support the training of other researchers in Africa to utilise these tools effectively. “The methods strengthen CERI’s initiatives by linking genomic surveillance with structural biology and computational modeling for vaccine and therapeutic design, positioning CERI not only to respond to epidemics and pandemics but also to drive solutions against them.
“I plan to share the skills I’ve acquired through both formal and informal channels to maximise impact. This includes presenting at CERI’s working group and sharing ideas for collaborative projects – ensuring that techniques like 3D protein prediction, visualisation, and docking become accessible to others working on diverse pathogens. Beyond CERI, I will engage with the broader African genomics community through conferences and collaborative networks.”
In addition, during the workshop, Isaac initiated a mentorship with Dr. Emmanuel Nji, CEO and Cofounder of Biostruct-Africa, focusing on AlphaFold and structure-guided epitope mapping to support his PhD work on Rift Valley fever virus. “Without a doubt, my top takeaway was learning how structural biology tools can transform genomic data into actionable insights that address global health challenges,” he concludes.
We recently completed a strategic trip to the U.K., holding ten meetings with funders, philanthropists, scientific leaders, and businesses to support CERI’s research, innovation, and training activities.
We recently embarked on a strategic and inspiring trip to the U.K. with an intense journey that involved ten meetings with funders, philanthropists, scientific leaders, and businesses. The goal was clear: to strengthen CERI’s collaborations with key scientific groups in the U.K. and engage potential partners who can support our research, innovation, and training activities. We, i.e. Prof Wim de Villiers, Dr Richard Gordon and I, joined this trip, making it a powerful opportunity to advance our mission.
Our journey began in Cambridge, continued through London, and concluded in Oxford. In Cambridge, we had an excellent meeting with Prof Pietro Liò and his team at the University of Cambridge. Prof Liò, a full professor in the Department of Computer Science and Technology and a member of the Cambridge Centre for AI in Medicine, shares our passion for using AI to accelerate science. Together, we explored ways to expand our AI for Science program to include exchanges between our MSc and PhD students and Cambridge University. Cambridge
colleagues already collaborate with Stellenbosch University and AIMS, and we are planning a significant program expansion starting in September 2026.
While in the U.K., we were also lucky to meet South African rugby legend Bob Skinstad, who captained the Springboks to a Rugby World Cup victory. Our discussion focused on potential collaboration with Elixrr, a U.K.based management consultancy firm that recently made strategic investments in Europe, including acquiring two AI/data science companies. Its founder, Stephen Newton, is a fellow Capetonian, and we are exploring how our team of AI scientists and postgraduate students could work with Elixrr on projects of mutual interest.
In London, our agenda included important visits to CEPI and Wellcome. CEPI is one of the largest global funders of biological countermeasure programs for priority pathogens. CERI has already worked with CEPI on the development of a vaccine for Rift Valley Fever Virus, one of Africa’s high-risk pathogens with pandemic potential. Prof Tulio de Oliveira has also been a keynote speaker at multiple high-level international events co-organised
by CEPI, including the Global Pandemic Preparedness Summit 2024 in Rio de Janeiro and the upcoming G20 Health and Pandemic Preparedness Program in 2025 in Johannesburg.
Our meeting with Wellcome, one of the world’s most influential global health foundations — was equally exciting. We sat down with Prof Alex Pym, Director of Infectious Disease, and his team to discuss projects on climate-amplified diseases like dengue. CERI already holds several Wellcome grants, and we are actively working to expand this critical partnership.
The final and perhaps most intense part of the trip took place in Oxford, where we spent two full days deepening our collaboration with the University of Oxford’s Pandemic Sciences Institute (PSI). PSI was established to translate the hard lessons learned from COVID-19 into actionable strategies to prepare for and prevent future pandemics. Together with PSI and partners across academia, industry, and public health, we aim to accelerate science-driven innovations — from faster diagnostics and treatments to vaccines and digital tools for outbreak control — with a strong emphasis on equitable access for resource-limited regions.
In Oxford, we met with the PSI leadership and faculty, including Sir Peter Horby (Director), Prof Christophe Fraser, Prof Moritz Kraemer, Prof David Aanensen, Dr Julia Dickinson, David Bartle, Philippa Johnstone, and Dr Jane Itzhaki. We dedicated a full day to structured meetings, during which PSI researchers presented their work and we engaged in productive,
forward-looking discussions. I also gave a presentation at the Big Data Institute, attended by nearly 100 faculty and researchers, sparking rich dialogue about potential collaborations between CERI and PSI. Plans are already underway to bring our British colleagues to Stellenbosch so that we can continue these conversations and transform ideas into action.
The trip concluded in London with a meeting with Google DeepMind, whose headquarters are nearby. Google DeepMind is already collaborating with CERI and AIMS through the AI for Science program, and we agreed to deepen this partnership. A Google team will visit CERI in late September as part of the G20 AI Program in South Africa, which will serve as a springboard for exploring even more ambitious joint projects.
In summary, our U.K. trip was demanding but deeply rewarding. Despite the full schedule and back-to-back high-level meetings, we returned energised, inspired, and more committed than ever to strengthening collaborations between CERI, Stellenbosch University, Cambridge and Oxford Universities, and our partners in industry and philanthropy across the U.K.
“Extending our collaborations with the Pandemic Science Institute at Oxford University, Google DeepMind and Cambridge University will bring much expertise to our team in South Africa”
- Prof Tulio de Oliveira
