MediWales LifeStories Magazine 2020

Page 51

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COVID-19 drug discovery platform in development Moleculomics, based at Swansea University Medical School, has been awarded funding from Innovate UK for technology development to find drug treatments for COVID-19 and other viral threats. The new in silico platform, GRASP (Generic Rapid Antiviral Screening Platform), will seek to get ahead of emerging strains of the virus by simulating the effects of mutations before they happen, and screening the new protein targets against libraries of drug compounds.

“The SARS-CoV-2 virus is mutating, though not particularly rapidly. There are several strains in circulation around the globe and the virus is still undergoing about 25 mutations per year. It is likely in time that these mutations will affect viral structure, drug specificity and pathogenicity, opening up new opportunities for drug targeting, for the current pandemic and future viral threats”. Dr Jonathan Mullins, CEO, Moleculomics

The company has recently developed the Human3DProteome platform, which contains the 3D structures of all of the proteins (receptors, transporters, enzymes etc) of the human body. They have also developed the Hit2Lead Portal, the first fully automated portal that provides a one-stop-shop for protein modelling and drug screening at all scales, from single receptor or single compound jobs to whole proteome screening. GRASP is the first dedicated antiviral screening platform to be developed by the company.

“There is a good deal of in silico screening going on, but we don’t know of anyone else who is simulating the impacts of future potential mutations.” Karl Austin-Muttitt, research scientist working on the project

The team will be working in close collaboration with academic and industrial partners, and the screening results relevant to treatment of COVID-19 disease, featuring interactions with approved drugs and wider chemical space, will be openly shared with partners and on the project website. Those interested in partnering, sharing information etc, please contact: info@moleculomics.com

www.moleculomics.com

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Articles inside

Innovation at CITER

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Cardiff University Biomechanics Research Facility hosts ‘first in Wales’ NHS service

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New research into dialysis options and choices

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The response to COVID-19 from Swansea University Medical School

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Roche: How a global pandemic became the ultimate test of partnership working

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Single Use Surgical supports Cavell Nurses’ Trust

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AliveCor: Detecting atrial fibrillation to prevent strokes

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Celebrating a landmark year for CellPath

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Patent Seekers: Patent search database as an intelligence tool

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Digital wound management with Healthy.io - The future of wound care comes to Wales

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COVID-19 drug discovery platform in development at Moleculomics

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Concentric Health: Remote consent supporting organisational recovery

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Sharp expands its commercial capabilities to UK facility

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SymlConnect: Digital remote patient monitoring during the COVID-19 pandemic and beyond

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Jellagen announces seed financing to develop advanced collagen products

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EKF supports COVID-19 testing with novel sample collection device

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COVID-19 antibody testing kit launched by Forth

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Hybrisan secures £500,000 to help fight

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Bond Digital Health: How coronavirus demonstrated the need for connected diagnostics and accelerated our development plans

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Indoor Biotech: Funding awarded to develop new COVID-19 T cell immunity test

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Life Sciences Hub Wales: Bringing Welsh

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Accelerate: Supporting innovation in Wales

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Health Technology Wales repurposes skills to

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Developing new technology to disinfect ambulances

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Delivering care closer to home with video consultations

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The Welsh Health Hack goes online for COVID-19 challenge

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AgorIP: bringing innovation to life across Wales

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Tackling the COVID-19 crisis together: The RIIC Hubs Network

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Transforming health and social care services for a healthier Wales

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NHS staff tackling COVID-19 use virtual reality to help reduce anxiety and stress

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VR experiences promote NHS career opportunities

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Reducing the use of unnecessary antibiotics for COPD

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Introducing a non-invasive prenatal test to Wales

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