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The First CN-Series Install at St. Thomas’ Hospital, London
Sysmex UK are proud to announce the first installation of their next generation family of haemostasis analysers, the CN-Series at Guy’s and St. Thomas’ Hospital, in London.
From Left to Right: Eleanor Foxton (Principal BMS), Kasia Mayger (Senior BMS), Aine McCormick (Principal BMS), Charlotte Noronha (Operations Manager), Clare Wigley (Senior BMS)
The introduction of the CN-Series to Guy’s and St. Thomas’ Hospitals as Sysmex UK’s first installation sites is made all the more special considering Sysmex’s history with this customer. From the CA-Series (with the CA-7000 and CA-1500 systems) to the CS-Series (with the CS-2000/2100i and CS-2400 systems), Sysmex UK have provided automated haemostasis analysers to Guy’s and St. Thomas’ hospitals for over 20 years! St. Thomas’ hospital have been expert evaluators of analytical systems over that time and have conducted studies on Lupus 1,2,3,4 , automated platelet aggregometry 5, and the importance of using an acceptable linear calibration curve for coagulation factor assays 6 using the CA and CS-Series analyers. The CN-Series offers the site advanced clinical services through haemostasis laboratory testing. The CN-Series, Sysmex’s most advanced haemostasis systems to date, have been created to provide a highly powerful solution by delivering answers to laboratory haemostasis testing requirements in terms of productivity, services, analytical and operational performance.
“The smaller footprint, high throughput, reduced maintenance and increased audit trail made the CN Series analysers the best option for our analyser refresh programme. The opportunity to be among the first labs to be using the new generation, state of the art systems is very exciting.” Jacqueline Cutler, Operations Manager for Viapath at St. Thomas’ Hospital At Guy’s and St. Thomas’ Hospitals, their need was for a compact yet high throughput solution for their routine laboratory. Two CN-6000 analysers have been installed into St. Thomas’ Hospital as a replacement for their current two CS-2100i’s for routine haemostasis testing, with a 22% saving on footprint delivering an unrivalled 900 test per hour capability, a 250% increase in throughput. Supported by an ever-expanding number of liquid ready-to-use reagents from HYPHEN Biomed SAS, improvements to the refrigerated reagent table allows the CN-Series to provide even longer on-board stability of reagents and reduce the frequency at which reagents require replacing.
“The faster turnaround times provided by the CN Series will benefit our staff and users enormously and I’m particularly looking forward to moving our platelet aggregometry assay to the fully automated CN platform.” Aine McCormick, Principal Biomedical Scientist for Viapath at St. Thomas’ Hospital
The CN-3000/6000 with Extended sampler provides a loading capacity of up to 120 samples at any one time
“Enhanced Quality Control (QC) options makes QC management easier with current and new QC lots to be performed concurrently, making QC batch acceptance simple. Also, the ability to run plasma-based controls and calibrators from their original vials as this will save errors in decanting reagents and is environmentally better too as it will reduce the number of plastic cups we use and barcode labels we print, also reducing the chance of transcription errors.” Clare Wigley, Senior Biomedical Scientist for Viapath at St. Thomas’ Hospital
In the coming weeks, Sysmex UK will also be installing a CN-6500 system into St. Thomas’ Hospital. The CN-6500 offers integrated chemiluminescence enzyme immunoassay (CLEIA) testing alongside ‘classical’ haemostasis testing of clot-based, immunoturbidimetric, chromogenic and aggregation assays. This means that that CN-6500 will allow haemostasis service providers to consolidate the widest test portfolio onto a single platform located in the haemostasis laboratory.
“The biggest difference to service provision is actually the improvement to stop reading once a clot has been detected, so we don’t always have to wait for a standardised measurement time to get the result. Personally, I am most looking forward to exploring the chemiluminescence on the CN-6500 and being able to streamline our testing through one analyser system.” Eleanor Foxton, Principal Biomedical Scientist for Viapath at St. Thomas’ Hospital With the increased walk-away time made possible with the CN-Series, this leaves more time to do other tasks in the laboratory (as well as enjoy the view).
Designed to provide power in productivity, analytical and operational performance, the CN-Series:
Maximises walk-away time with the extended sampler, with a loading capacity of 120 samples at any one time. Shortens the time to result for clot-based tests to less than 4.5 minutes from sample aspiration. Provides customisable multi-sample volume and assayspecific HIL checks to confirm sample fill volume & detect the presence of interfering substances in samples, to ensure sample quality. Reduces system down-time by the performance of automatic ‘self-checks’ and enhancements made to the sample probe and light source.
The CN-6500 adds chemiluminescence testing of immunological assays to the 4 detection methods of the CN-6000 model. Resulting in random access CLEIA, clotbased, immunoturbidimetric, chromogenic and aggregation testing on one system.
References
1) Moore GW, Kumano O. (2020). Lupus anticoagulant assay cut-offs vary between reagents even when derived from a common set of normal donor plasmas. J Thromb Haemost. 2) Kumano O, Moore GW. (2019). Ruling out lupus anticoagulants with the mixing test-specific cut-off assessment and the index of circulating anticoagulant. Res Pract Thromb Haemost. 3) Moore GW, Peyrafitte M, Dunois C, Amiral J. (2018). Newly developed dilute Russell’s viper venom reagents for lupus anticoagulant detection with improved specificity. Lupus. 4) Moore GW, Rangarajan S, Savidge GF. (2008). The activated seven lupus anticoagulant assay detects clinically significant antibodies. Clin Appl Thromb Hemost. 5) Platton S, McCormick A, Bukht M, Gurney D, Holding I, Moore GW. (2018). A multicenter study to evaluate automated platelet aggregometry on Sysmex CS-Series coagulation analyzers-preliminary findings. Res Pract Thromb Haemost. 6) Moore GW, Dunsmore C. (2017). The Importance of Using an Acceptable Linear Calibration Curve for Coagulation Factor Assays. Viapath News and Press. (http://www.viapath.co.uk/news-and-press/the-importance-of-usingan-acceptable-linear-calibration-curve-for-coagulation-factor)
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