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WITH  A  SAMPLE  OF   HEALTHY  SKIN  THE   SIZE  OF  THIS  SQUARE  

WE  COVER  SKIN  TISSUE  LOSS  OF   AN  AREA  FOUR  TIMES  THE  SIZE   OF  THIS  CARD  

keradermlab@gmail.com Tel. (571) 2562631 Movil. (573) 3106183485 Calle 90 # 19A-49 oficina 801

Jorge Soto Partner CFO

Bogotá, Colombia

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WHAT  CAN  CAUSE  SKIN  TISSUE  LOSS   BURNS  

ULCERS  

TRAUMAS  

TUMORS  

•   1%  of  the  world  populaGon  will  suffer  at  some  point  in  his  life  a  severe  burn.   •   Annually,  1  million  Europeans  and  1.5  million  Americans  receive  medical  aTenGon  for   burns   •   Chronic  wounds  in  USA  affect  6.5  million  with  esGmated  treatment  costs  of  $25  billion   per  year.   •   0.2%  of  the  UK  populaGon  suffers  chronic  ulcers  

Estrictamente Privado y Confidencial

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CURRENT  TREATMENT  OF  SKIN  TISSUE  LOSS  

PARTIAL  THICKNESS  SKIN  GRAFT  

APPLICATION  OF  A   PROTECTIVE  COVERAGE  IN   THE  AFFECTED  AREA  

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PARTIAL  THICKNESS  SKIN  GRAFT   SEVERE  PAIN  

SIGNIFICANT  SCARRING  

COMPLICATIONS  INHERENT  TO  ANY  OTHER   SURGICAL  PROCEDURE   Estrictamente Privado y Confidencial

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ONE  TRUE  STORY  

22  days  old  premature   baby    

Skin  Hssue  loss   Sample  CollecHon  

5  to  7  days  in  Keraderm  Lab  

4×4in  skin-­‐cell-­‐coated   sheets  

Estrictamente Privado y Confidencial

Keraderm  Applied  

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KERADERM´S  ADVANTAGES   NO  ADDITIONAL  TRAUMA  TO  THE  PATIENT  AND  IT  IS  PAINLESS  

NO  ADDITIONAL  SCAR  TO  THAT  OF  THE  AFFECTED  AREA    

THE  PROCEDURE  DOES  NOT  NEED  TO  BE  CONDUCTED  IN  THE  OR  

IT  IS  MANAGEABLE  BY  NURSES  AND  PHYSICIANS  OF  ANY  SPECIALTY  

REPLICABLE  ANYWHERE  IN  THE  WORLD,  INCLUDING  DEVELOPING  COUNTRIES  

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ONE  TRUE  STORY   30  DAYS  AFTER  APPLYING  KERADERM  

Estrictamente Privado y Confidencial

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OTHER  STORIES  

PreoperaGve  

15  Days  A[er  

30  Days  A[er  

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OTHER  STORIES   78  YEARS  OLD   TUMOR  

PreoperaGve  

30  Days  A[er   10


OTHER  STORIES   4  YEARS  OLD   TRAUMA  

60  Days  A[er  

PreoperaGve  

Estrictamente Privado y Confidencial

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OTHER  STORIES   2  YEARS  OLD   BURN  

PreoperaGve  

25  Days  A[er   Estrictamente Privado y Confidencial

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ü   PlasGc  Surgeons:  

MARKET  

•   Colombia:  657     •   Bogota:  288     •   Cali:  93     •   Rest  of  the  Country:  177   ü   HMOs,  and  Hospitals  in   Bogota:   •   22  State  Social  Enterprises   (Hospitals)   •   24  EPS   •   14  HMOs   ü   InternaGonal  Market  

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MARKET   PATIENT  IS  THE  FINAL  USER  OF  KERADERM  

•   1  million  people  suffer  burns  every  year   that  require  medical  treatment  

•   50,000  people  suffer  burns  every  year   •   10%  of  which  require  hospitalizaGon  

•   500.000  require  hospitalizaGon   •   25.000  go  to  burns  unit  

•   1%  die  as  a  consequence  

•   10.000  die  due  to  complicaGons    

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MARKETING   CONFERENCES  AND  MEETINGS  

PUBLICATIONS   PRESENTATIONS  TO  PLASTIC  SURGEONS  

PRESENTATIONS  TO  HOSPITAL  STAFF   PUBLIC  MEDIA  

Estrictamente Privado y Confidencial

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EVOLUTION   2010   • PatenGng  process  started   (Patent  CooperaGon  Treaty)    

2012   • Capital  raised  among   investors     • First  Keraderm  Lab  

• Design  of  a  clinical  trial  with   a  larger  populaGon  sample   2008  

2012

• Skin  cell  culture  method   standardized.   • SaGsfactory  results  in  10   paGents  

2011 2010

2009

2010 2009  

2008

2008

2008

2011   • Research  study  in  4  hospitals   in  Bogotá     • 48  paGents  were  treated  

• NaGonal  PlasGc  Surgery  Congress  

• The  study  followed  legal  and   ethical  guidelines.  

• Granted  the  Guillermo  Nieto   Cano  Award  

•   Won  Ventures  compeGGon  

• Published  in  the  Colombian   Magazine  of  PlasGc  Surgery   16


2013   OPENING  OF  A  KERADERM  LAB  IN  A  MAJOR  CITY  IN  COLOMBIA      AND  CONSOLIDATION  OF  OUR  PATENT  PROCESS  

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COMPETITORS   THE RECONSTRUCTIVE LADDER PROCEDURE  

ADVANTAGES  

DISADVANTAGES    

Healing  by  second   intenGon  

•   No  advantages   idenGfied  

•   Longer  healing  process   •   Worst  scars  on  treated  areas  

ParGal  thickness  skin   gra[s  

•   Most  commonly  used   procedure  

Cadaver  skin  gra[    

•   Immediate  availability  

•   Notorious  addiGonal  scarring  and  very   painful   •   OR  required  under  anesthesia   •   More  risky  and  expensive   •   Not  a  definiGve  procedure     •   The  gra[  is  always  rejected  

Skin  subsGtutes  

•   Immediate  availability  

•   AddiGonal  procedures  required   •   Higher  costs  

Donor  skin  cell  cultures    

•   Immediate  availability  

•   Extremely  high  costs  of  culture   •   Tests  required  to  rule  out   incompaGbiliGes   •   Unavailable  in  developing  countries  

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TEAM  AND  PARTNERS   Gabriel  Soto   Legal  Advisor  

Jorge  Soto   CFO  

Jenifer  Gaona   PlasGc  Surgeon   Product  Developer  

Rodrigo    Soto   PlasGc  Surgeon   CEO  

Juan  Zambrano   PlasGc  Surgeon   Product  Developer   Eduardo  Soto   Chairman  of  the   Board  

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WITH  A  SAMPLE  OF   HEALTHY  SKIN  THE   SIZE  OF  THIS  SQUARE  

WE  COVER  SKIN  TISSUE  LOSS  OF   AN  AREA  FOUR  TIMES  THE  SIZE   OF  THIS  CARD  

keradermlab@gmail.com Tel. (571) 2562631 Movil. (573) 3106183485 Calle 90 # 19A-49 oficina 801

Jorge Soto Partner CFO

Bogotá, Colombia

Estrictamente Privado y Confidencial

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BURNS  AND  OTHER  SKIN  TISSUE  LOSSES  ARE   CURRENTLY  TREATED  WITH  PARTIAL  THICKNESS  SKIN   GRAFTS,  A  PAINFUL  PROCEDURE  THAT  GENERATES   ADDITIONAL  SCARRING  AND  HAS  TO  BE  CARRIED  OUT   IN  AN  OR  UNDER  ANESTHESIA  CARRYING   COMPLICATIONS  INHERENT  TO  SURGICAL   PROCEDURES.  KERADERM  CONSISTS  OF  4×4IN  SKIN-­‐ CELL-­‐COATED  SHEETS,  GENERATED  FROM  CELLS   CULTURED  OF  THE  SAME  PATIENT.  IT  IS  A  PAINLESS   NON  SURGICAL  PROCEDURE  WITH  A  SIGNIFICANT   DECREASE  IN  COSTS  AND  WITH  COMPLETE  HEALING  IN   VERY  SHORT  PERIOD  OF  TIME   21


Keraderm Lab