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WITH A  SAMPLE  OF   HEALTHY  SKIN  THE   SIZE  OF  THIS  SQUARE  

WE COVER  SKIN  TISSUE  LOSS  OF   AN  AREA  FOUR  TIMES  THE  SIZE   OF  THIS  CARD  

keradermlab@gmail.com Tel. (571) 2562631 Movil. (573) 3106183485 Calle 90 # 19A-49 oficina 801

Jorge Soto Partner CFO

Bogotá, Colombia

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WHAT CAN  CAUSE  SKIN  TISSUE  LOSS   BURNS  

ULCERS

TRAUMAS

TUMORS

•  1%  of  the  world  populaGon  will  suffer  at  some  point  in  his  life  a  severe  burn.   •   Annually,  1  million  Europeans  and  1.5  million  Americans  receive  medical  aTenGon  for   burns   •   Chronic  wounds  in  USA  affect  6.5  million  with  esGmated  treatment  costs  of  $25  billion   per  year.   •   0.2%  of  the  UK  populaGon  suffers  chronic  ulcers  

Estrictamente Privado y Confidencial

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CURRENT TREATMENT  OF  SKIN  TISSUE  LOSS  

PARTIAL THICKNESS  SKIN  GRAFT  

APPLICATION OF  A   PROTECTIVE  COVERAGE  IN   THE  AFFECTED  AREA  

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PARTIAL THICKNESS  SKIN  GRAFT   SEVERE  PAIN  

SIGNIFICANT SCARRING  

COMPLICATIONS INHERENT  TO  ANY  OTHER   SURGICAL  PROCEDURE   Estrictamente Privado y Confidencial

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ONE TRUE  STORY  

22 days  old  premature   baby    

Skin Hssue  loss   Sample  CollecHon  

5 to  7  days  in  Keraderm  Lab  

4×4in skin-­‐cell-­‐coated   sheets  

Estrictamente Privado y Confidencial

Keraderm Applied  

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KERADERM´S ADVANTAGES   NO  ADDITIONAL  TRAUMA  TO  THE  PATIENT  AND  IT  IS  PAINLESS  

NO ADDITIONAL  SCAR  TO  THAT  OF  THE  AFFECTED  AREA    

THE PROCEDURE  DOES  NOT  NEED  TO  BE  CONDUCTED  IN  THE  OR  

IT IS  MANAGEABLE  BY  NURSES  AND  PHYSICIANS  OF  ANY  SPECIALTY  

REPLICABLE ANYWHERE  IN  THE  WORLD,  INCLUDING  DEVELOPING  COUNTRIES  

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ONE TRUE  STORY   30  DAYS  AFTER  APPLYING  KERADERM  

Estrictamente Privado y Confidencial

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OTHER STORIES  

PreoperaGve

15 Days  A[er  

30 Days  A[er  

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OTHER STORIES   78  YEARS  OLD   TUMOR  

PreoperaGve

30 Days  A[er   10


OTHER STORIES   4  YEARS  OLD   TRAUMA  

60 Days  A[er  

PreoperaGve

Estrictamente Privado y Confidencial

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OTHER STORIES   2  YEARS  OLD   BURN  

PreoperaGve

25 Days  A[er   Estrictamente Privado y Confidencial

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ü  PlasGc  Surgeons:  

MARKET

•  Colombia:  657     •   Bogota:  288     •   Cali:  93     •   Rest  of  the  Country:  177   ü   HMOs,  and  Hospitals  in   Bogota:   •   22  State  Social  Enterprises   (Hospitals)   •   24  EPS   •   14  HMOs   ü   InternaGonal  Market  

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MARKET PATIENT  IS  THE  FINAL  USER  OF  KERADERM  

•  1  million  people  suffer  burns  every  year   that  require  medical  treatment  

•  50,000  people  suffer  burns  every  year   •   10%  of  which  require  hospitalizaGon  

•  500.000  require  hospitalizaGon   •   25.000  go  to  burns  unit  

•  1%  die  as  a  consequence  

•  10.000  die  due  to  complicaGons    

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MARKETING CONFERENCES  AND  MEETINGS  

PUBLICATIONS PRESENTATIONS  TO  PLASTIC  SURGEONS  

PRESENTATIONS TO  HOSPITAL  STAFF   PUBLIC  MEDIA  

Estrictamente Privado y Confidencial

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EVOLUTION 2010   • PatenGng  process  started   (Patent  CooperaGon  Treaty)    

2012 • Capital  raised  among   investors     • First  Keraderm  Lab  

• Design of  a  clinical  trial  with   a  larger  populaGon  sample   2008  

2012

• Skin cell  culture  method   standardized.   • SaGsfactory  results  in  10   paGents  

2011 2010

2009

2010 2009

2008

2008

2008

2011 • Research  study  in  4  hospitals   in  Bogotá     • 48  paGents  were  treated  

• NaGonal PlasGc  Surgery  Congress  

• The study  followed  legal  and   ethical  guidelines.  

• Granted the  Guillermo  Nieto   Cano  Award  

•  Won  Ventures  compeGGon  

• Published in  the  Colombian   Magazine  of  PlasGc  Surgery   16


2013 OPENING  OF  A  KERADERM  LAB  IN  A  MAJOR  CITY  IN  COLOMBIA      AND  CONSOLIDATION  OF  OUR  PATENT  PROCESS  

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COMPETITORS THE RECONSTRUCTIVE LADDER PROCEDURE  

ADVANTAGES

DISADVANTAGES  

Healing by  second   intenGon  

•  No  advantages   idenGfied  

•  Longer  healing  process   •   Worst  scars  on  treated  areas  

ParGal thickness  skin   gra[s  

•  Most  commonly  used   procedure  

Cadaver skin  gra[    

•  Immediate  availability  

•  Notorious  addiGonal  scarring  and  very   painful   •   OR  required  under  anesthesia   •   More  risky  and  expensive   •   Not  a  definiGve  procedure     •   The  gra[  is  always  rejected  

Skin subsGtutes  

•  Immediate  availability  

•  AddiGonal  procedures  required   •   Higher  costs  

Donor skin  cell  cultures    

•  Immediate  availability  

•  Extremely  high  costs  of  culture   •   Tests  required  to  rule  out   incompaGbiliGes   •   Unavailable  in  developing  countries  

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TEAM AND  PARTNERS   Gabriel  Soto   Legal  Advisor  

Jorge Soto   CFO  

Jenifer Gaona   PlasGc  Surgeon   Product  Developer  

Rodrigo  Soto   PlasGc  Surgeon   CEO  

Juan Zambrano   PlasGc  Surgeon   Product  Developer   Eduardo  Soto   Chairman  of  the   Board  

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WITH A  SAMPLE  OF   HEALTHY  SKIN  THE   SIZE  OF  THIS  SQUARE  

WE COVER  SKIN  TISSUE  LOSS  OF   AN  AREA  FOUR  TIMES  THE  SIZE   OF  THIS  CARD  

keradermlab@gmail.com Tel. (571) 2562631 Movil. (573) 3106183485 Calle 90 # 19A-49 oficina 801

Jorge Soto Partner CFO

Bogotá, Colombia

Estrictamente Privado y Confidencial

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BURNS AND  OTHER  SKIN  TISSUE  LOSSES  ARE   CURRENTLY  TREATED  WITH  PARTIAL  THICKNESS  SKIN   GRAFTS,  A  PAINFUL  PROCEDURE  THAT  GENERATES   ADDITIONAL  SCARRING  AND  HAS  TO  BE  CARRIED  OUT   IN  AN  OR  UNDER  ANESTHESIA  CARRYING   COMPLICATIONS  INHERENT  TO  SURGICAL   PROCEDURES.  KERADERM  CONSISTS  OF  4×4IN  SKIN-­‐ CELL-­‐COATED  SHEETS,  GENERATED  FROM  CELLS   CULTURED  OF  THE  SAME  PATIENT.  IT  IS  A  PAINLESS   NON  SURGICAL  PROCEDURE  WITH  A  SIGNIFICANT   DECREASE  IN  COSTS  AND  WITH  COMPLETE  HEALING  IN   VERY  SHORT  PERIOD  OF  TIME   21

Keraderm Lab  

Keraderm skoin grouth

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