Further Reading

 Liposomal forms  Removal of doxorubicin in lymphoma regimens  Growth factors

Abbreviations: PK, pharmacokinetics; AUC, area under the curve; PD, pharmacodynamics; CHOP, cyclophosphamide, doxorubicin, vincristine, and prednisone; AC, doxorubicin and cyclophosphamide.

Source: Courtesy of Elsevier.

• Gonsalves W, Ganti AP. Targeted anti-cancer therapy in the elderly. Crit rev oncol hematol 2011; 78:227-242 • Kelly CM, Power DG, Lichtman SM. Targeted therapy in older patients with solid tumors. J Clin Oncol. 2014;32:2635-46 • Lichtman SM, Wildiers H, Chatelut E, et al. International Society of Geriatric Oncology chemotherapy taskforce: evaluation of chemotherapy in older patients—an analysis of the medical literature. J Clin Oncol 2007; 25:1832–1843. • Lichtman SM, Wildiers H, Launay-Vacher V, et al. International Society of Geriatric

Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency. Eur J Cancer 2007; 43:14–34. • Mohile SG, Hardt M, Tew W et al; Cancer and Aging Research Group. Toxicity of bevacizumab in combination with chemotherapy in older patients. Oncologist. 2013;18:408-414. • Wildiers H, Highley MS, De Bruijn EA, et al. Pharmacology of anticancer drugs in the elderly population. Clin Pharmacokinet 2003; 42:1213–1242. • Wildiers H. Mastering chemotherapy dose reduction in elderly cancer patients. Eur J

Cancer 2007; 43:2235–2241.