Peyronie’s disease: causes, diagnosis and treatment Peyronie’s disease is an inflammatory process that causes a fibrous plaque in the erectile tissue that can
hurt and slope the penis amid erection. This disease was first described by French surgeon Francois Leg of the Peyronie.
Francois Leg of Peyronie
There are two all around characterized phases in Peyronie’s disease:
Inflammatory phase: a plaque forms in the corpora cavernosa of the penis that produces torment , progressive incurvation and shortening of the penis.
Stabilization phase: at 6year and a half the plaque hardens, the torment disappears, and the degree of curvature slows down its progression.
Notwithstanding causing curvature and torment in the penis, Peyronie’s disease can be associated with erectile
dysfunction of psychogenic cause, by capture of the dorsal nerve of the penis in the fibrosis plate, by
an extremely stamped distortion that prevents penetration, or by vascular causes.
Peyronie’s disease is more continuous at more established ages . As indicated by the statistics, it affects 1.5% of men somewhere in the range of 30 and 39 years of age, 3% somewhere in the range of 40 and 59, 4% somewhere in the range of 60 and 69, and 6.5% in those more than 70 years of age.
Causes of Peyronie’s disease
The starting point Peyronie’s disease is obscure . It is realized that there is an association with different diseases
that influence the fibrous tissue to develop in different areas of the body such as Dupuytren’s disease, plantar fibrosis (in the feet) or tympanosclerosis .
We also know some of the risk factors for building up Peyronie’s disease: penile injury, urethral instrumentation , diabetes, elevated cholesterol, gout, Paget’s disease , hypertension, liquor, tobacco, betablocker drugs, family history.
There are different theories to clarify Peyronie’s disease:(peyronie’s disease treatment) Hypothesis of injury with irregular scarring: with age the elasticity of the penis decreases, as well as its
limit with respect to torsion. Rehashed microtrauma amid sexual intercourse could deliver a fibrous plaque in predisposed individuals.
Rehashed urethral control or intracavernous injections: this hypothesis would just clarify a couple of cases in which there have been urethral instrumentations or injections in the penis to treat erectile dysfunction.
Immunogenetic hypothesis: endorsed by the association with Dupuytren’s disease or plantar fibrosis. In
expansion, some specific antibodies have been found in the fibrous tissue of the penis.
Peyronie’s disease
Diagnosis of Peyronie’s disease
The diagnosis of Peyronie’s disease is clinical. Usually the meeting in the consultation and the physical examination for the diagnosis are sufficient . The selfphotographs that the patient takes in
erection in the 3 planes of the space (from above, from the side and from the front) assist the urologist with getting a thought of the intensity and course of the curvature of the penis. In some cases, an intracavernous infusion might be necessary in the workplace to all the more likely investigate the distortion.
The ultrasound and MRI penis can help decide if fibrous plaque is calcified or not (regardless of whether it is
calcified response to medicinal treatment is poor). Doppler ultrasound also serves to assess the state of the penile arteries.
Peyronie’s disease
Treatment of Peyronie’s disease
On the off chance that left untreated, Peyronie’s disease progresses in 48% of cases, stabilizes in 40% and improves spontaneously in 12%. The modalities of treatment that exist are the accompanying:
Medicinal treatment: it is shown in the inflammatory phase of the disease for the help of agony and the stabilization of the curvature. Medicinal treatment is viable in stopping irritation, yet it infrequently reverses the curvature. The most ordinarily used drugs are potassium Paraminobenjoyito, vitamin E
furthermore, colchicine. Others such as Lcarnitine, pentoxifylline or tamoxifen have been used extensively in the past, however studies have not affirmed their efficacy. Intraplaque treatment: the infusion of interferon alfa2B, verapamil or collagenase can be
successful in diminishing the size of the plaque and the degree of curvature. The last medication, a chemical from the bacterium Clostridium histolyticum , has as of late been endorsed by the European Medicines Agency for use in Peyronie’s disease. Verapamil 15% gel is also viable used two times every day for 912 months.
Footing devices: if joined with oral or intraplate treatments, they help diminish curvature and extend(whatis peyronie’s disease) the penis more than 912 months. There are numerous in the market, yet they might not have sanitary and quality guarantees and may not be dependable. I suggest my patients Andropeyronie Andromedical SL It organization with universal implantation, producer and distributor of vacuum pumps for erectile dysfunction, and devices for penis development and redress of curvatures. It has sanitary licenses for its products in the United States , Europe, Australia, Russia, Canada, Mexico and Asian
countries and meets ISO quality standards. It is worth 200 euros and the online sale is solid. Here is a connection for the online purchase of Andropeyronie .
Surgical treatment: it is demonstrated in stabilized curvatures that keep the sexual demonstration or make it agonizing for the man or his accomplice, when the previous treatments have
fizzled. In patients with exceptionally calcified plaques, it can be offered as the first treatment alternative. The
simplest surgery consists in giving points as an afterthought opposite the plate to accumulate the penis and
straighten it (plication techniques). At the point when the curvature is extremely articulated, it might be necessary to expel
the plaque and its scope usually with synthetic materials . On the off chance that there is severe associated erectile dysfunction, it is best to put a penile prosthesis .
At last, there is no miraculous oral or intraplaque treatment that superbly straightens the penis.
Most of the time, the pharmacological treatment aims to diminish the curvature enough so that you can have relationships without problems. Surgery, when necessary, can adjust the curvature well. In any case, we must realize that with plication techniques the penis is shortened 1 2 cm, and that with the techniques of incision/
excision and fix application there is a risk of causing erectile dysfunction. In the event that you should be
worked, my recommendation is that you search for a surgeon exceptionally experienced in this sort of surgical mediation (peyronies
disease)
peyronies disease