IPI Spring 2020

Page 74

Manufacturing

Help Your Tablet Tooling to Pack a Punch with Essential Maintenance Measures Ensuring tablet punches and dies are kept in optimum condition to produce high-quality tablets is critical for productivity and overall equipment efficiency (OEE). The reality is, however, that tablet compression tools are often viewed as consumable items, therefore maintenance can be seen as unnecessary and time-consuming. This can be a costly mistake and directly affect production. Keeping tooling in good working condition not only reduces tablet press downtime, but also minimises compression problems. When combined with a management system to monitor all aspects of the punches and dies, high-quality tablets are produced quickly and efficiently.

Consequences of Poor Maintenance Practices There are many problems which are a result of badly maintained tooling from poor handling through to insignificant monitoring. One of the most common is sticking and picking. When in an optimum condition, the surfaces of a tablet punch face are usually polished to a high mirror finish (the exception to this are textured finishes designed to alleviate specific sticking issues). This

Implementing an effective E-leaning programme can be an invaluable initiative to improve productivity.

finish can deteriorate over a period of time due to the continuous compaction of granules. This deterioration can lead to tabletting defects like sticking which occurs from the adhesion of the granule to the worn uneven finish. This degradation in the tool’s surface can be identified during proper assessment and rectified by cleaning granule from the surface and through polishing. When required light polishing using an automated polishing system

To achieve optimum lifetime and performance from tablet tooling use a planned 7 step maintenance process. 72 INTERNATIONAL PHARMACEUTICAL INDUSTRY

is recommended, this should enable a smooth and efficient surface to be maintained, thus aiding the reduction of sticking and picking issues. Get a Handle on it Damage through handling is another familiar problem when it comes to tooling defects. Approximately 80% of damage to punches and dies is caused accidentally when handling the punches through the production and tool care processes. This ‘accidental’ damage can lead to significant production failings. It is important to understand the delicate nature of the tooling and treat it with respect.

80% of damage to punches and dies is caused accidentally when handling the tooling. Ensure they are handled correctly to prevent damage. Spring 2020 Volume 12 Issue 1


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How Advancements in Logistics Technology will Play a Role in Combating COVID-19

7min
pages 96-99

Generic Solid Oral Immediate Release Products in EU Regulatory Perspectives Dissolution Specification

21min
pages 78-85

User Testing: Critical for Truly Understanding

8min
pages 86-87

New Tools and Models Designed to Optimise Costs

7min
pages 94-95

Automated Quality Systems in Supply Chains

11min
pages 90-93

Q&A with Brussels Airport, Changi Airport

9min
pages 88-89

Help Your Tablet Tooling to Pack a Punch with

12min
pages 74-77

The Electronic Laboratory Notebooks: Addressing

11min
pages 68-73

Cardiac Imaging in Clinical Development: The

13min
pages 64-67

Why Connected Data is Crucial to Pharmaceutical Research

9min
pages 58-61

Caregivers in Oncology: How to Address the Needs

7min
pages 52-53

Proveris by Design: A Roadmap for In Vitro Characterisation of Combination Products

14min
pages 46-51

Taking Charge of the Clinical Trial Master File

8min
pages 62-63

Study Oversight Models & Implementation in Clinical Trials

9min
pages 54-57

Manufacturing Dpis: An Engineering Perspective (A Case Study)

7min
pages 42-45

Five Questions You Should Ask when Developing an

10min
pages 38-41

Rethinking Inhaler Systems from a Patient Perspective The Increasing Challenge of Technology Diversity

12min
pages 34-37

Driving R&D Towards 2030 – Waging War on Carbon

10min
pages 16-19

Challenges of Drug Development in Progressive Multiple Sclerosis

15min
pages 28-31

The Future Market Dynamics and Opportunities in Immune Oncology

11min
pages 20-23

Understanding the Health Dimensions of the Climate Crisis

10min
pages 24-27

Editor’s Letter

7min
pages 8-11

Enabling Competitive Entry: The Role of Drug Delivery Device Design in the Biosimilars Market

8min
pages 32-33

Excessive Prices in The Pharma Sector: The EU Antitrust Perspective

11min
pages 12-15
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