EXPERIMENTAL ONCOLOGY & MOLECULAR MEDICINE DEPARTMENT
EXPERIMENTAL ONCOLOGY & MOLECULAR MEDICINE DEPARTMENT
DIRECTOR OF DEPARTMENT Maria Grazia Daidone phone: +39 02 2390 2238 mariagrazia.daidone@istitutotumori.mi.it
UNITS IMMUNOBIOLOGY OF HUMAN TUMORS Andrea Anichini MOLECULAR THERAPIES Silvana Canevari MOLECULAR IMMUNOLOGY Mario P. Colombo BIOMARKERS Maria Grazia Daidone CHEMOPREVENTION Maria Grazia Daidone MOLECULAR MECHANISMS OF CELL CYCLE CONTROL Domenico Delia MOLECULAR MECHANISMS Angela Greco IMMUNOTHERAPY OF HUMAN TUMORS Licia Rivoltini TUMOR GENOMICS Gabriella Sozzi MOLECULAR TARGETING Elda Tagliabue MOLECULAR PHARMACOLOGY Nadia Zaffaroni
The Department of Experimental Oncology and Molecular Medicine includes 11 Research Units dedicated to experimental research. In 2010, the redevelopment of a new building, fully dedicated to preclinical research and located closed to the historical INT site, was completed. Eight of the 11 research Units of the Department moved to this new building, in which 3,650 m2 are available for laboratories and meeting rooms, with 600 m2 for open space-laboratories, 14 sterile rooms, a dedicated area for radioactive manipulations, a cryogenic area of 220 m2, and areas for advanced technologies. The primary goal of the Department is to serve as an important conduit through which new discoveries are applied to cancer diagnosis, prognosis, and treatment. This is fostered by a strong collaboration and interaction among physicians and preclinical investigators working in different disciplines. The Department provides several shared research resources, which support investigators with well-equipped facilities and trained specialists. The following resources are available. • Immunohistochemistry (Technical Specialist: Lorena Ventura and Lucia Gioiosa): the histopathology facility assists investigators in research projects that require histological and cytological processing, including tissue microarrays. In addition to routine processing of tissue and cells, the service assists researchers with a full range of histological techniques, immunohistochemistry, in situ hybridization, and autoradiography. • Cell imaging facility (Technical Specialist: Patrizia Casalini, Biol Sci D): the laboratory is equipped with a BioRad Radiance 2000 laser confocal microscope (Nikon Diaphot Inverted) with a 15 mW krypton/argon laser source allowing for a wide range of fluorescent dye use (488, 569 and 647 nm excitation wavelengths). Sequential and simultaneous three channel image collection is possible along with bright field imaging. Live cell
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