Medical Device Coatings by Ubiquick

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Medical Device Coatings Published on May 2012

Report Summary REPORT SCOPE INTRODUCTION STUDY GOAL AND OBJECTIVES This study examines the medical device coating and surface modification treatment industry, a global enterprise that BCC Research anticipates will reach nearly $8 billion by 2017. It describes the eight coating and surface treatment technologies that add value to more than 1,000 types of medical devices used in 19 healthcare areas. Forecasts for each healthcare area project demand from 2012 through 2017. In addition to global summaries, separate forecasts are provided for the United States, the European Union, other developed nations and the rest of the world. REASONS FOR DOING THE STUDY In the six years since BCC Research undertook its first comprehensive study of the medical device coatings and surface modification treatment industry, the business has responded to a shifting balance of driving and limiting forces originating from within and outside the healthcare and coating communities. During that time, the fast pace of technological advances that originally drove the industry has slowed. While innovation continues, its focus has shifted away from new coating materials to improving products already in use. The regulatory environment likewise evolved. Requirements that were vague at the beginning of the new century formalized with the creation of a new U.S. Food and Drug Administration (FDA) office created to oversee so-called combination products. Earlier this year (2012), the National Academy of Sciences' Institute of Medicine (IOM), the nation's leading independent authority on medical science, called for a complete overhaul of the FDA regulatory process through which new products come to market. The announcement came as new studies raised questions not only about the comparative efficacy of two major types of coated metal products, arterial stents and artificial hip joints, but also the FDA's mechanism for identifying poorly performing products. Against that backdrop of regulatory uncertainty, the industry has been forced to confront unanticipated economic times stemming from the 'jobless recovery' following the 2008 recession and the sovereign debt crisis in Europe. Greater regulatory and economic uncertainty looms on the horizon. As this study goes to press, the U.S. Supreme Court is deliberating the legality of a federal law that, beginning in 2014, would fine Americans who refuse to purchase private health insurance. INTENDED AUDIENCE This study will be of interest to stakeholders in the medical device industry; the coatings and surface treatments industries; suppliers of alloys, ceramics, polymers, and other materials used in the manufacture of coatings; manufacturers of chemicals, pharmaceuticals, and energy sources that can be incorporated into coatings; coating and medical device importers; medical device contract manufacturers; and the regulatory community and healthcare policy analysts. It will also provide useful insights for those exploring investments opportunities in what despite regulatory and economic uncertainty remains a vibrant and growing segment of the medical device industry.

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>> Get this Report Now by email! SCOPE AND FORMAT This study looks at medical device coatings and surface treatments from the perspective of both the supply and demand side of the equation, that is from coating manufacturers who supply the materials, the medical device companies which use it and the members of the healthcare that influence purchases. Consistent with the scope of the study, the format of this report is arranged to present its five-year forecasts as a series of tables. Each of those tables presents U.S. current dollar demand values for coatings and surface processes for 2010 and 2011 and a five-year period from 2012 through 2017. Separate sets of forecasts are presented for the: Eight types of coatings and surface treatment technologies. 19 healthcare areas that correspond to FDA medical device review panels. United States, European Union, other developed nations and the rest of the world. TECHNOLOGIES We present forecasts for the seven basic types of coatings plus surface treatment technologies. Coatings are grouped on the basis of their most distinguishing chemical or physical characteristic. Surface treatments are defined as those processes that alter the surface of a device without adding a chemical or physical agent. For example, we characterize chrome plating as a type of alloy coating, rather than a surface treatment. The eight types of technology addressed in this study are: Alloy. Ceramic. Combination. Energy-absorbing. Energy-emitting. Micro and nano. Protective polymer. Surface treatment. HEALTHCARE AREAS Our forecasts by healthcare area follow the disciplinary divisions used by the FDA in creating its medical device review panels. The 19 healthcare areas are: Anesthesiology. Cardiovascular. Chemistry. Dental. Ear, nose and throat. Gastroenterology and urology. General and plastic surgery. General hospital use. Hematology. Immunology. Microbiology Neurology. Obstetrics and gynecology.

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>> Get this Report Now by email! Ophthalmology. Orthopedics. Pathology. Physical medicine. Radiology. Toxicology. COUNTRIES AND REGIONS In this study we report both global and regional forecast values for the following countries and regions: United States. European Union. Other developed nations. The Rest of the world. The forecast values for the United States include Puerto Rico, a major manufacturing center for many medical devices labeled as made in the United States. The EU forecast contains only those 27 countries that were full members on March 1, 2012. Assignment to one of the remaining groups is based on the World Bank's determination of each economy's per capita gross national income (GNI) on July 1, 2011. Other developed nations are those where the per capita GNI is $12,276 and above. The rest of the world forecast group contains countries for which the World Bank reported a per capita GNI of $12,275 and below. Each of the 191 countries for which BCC Research deemed there was sufficient forward-looking healthcare information to permit forecasting has been assigned to one and only one regional group. Thus, the developed nations group excludes the United States and EU member countries. In tables that identify countries, we use their common rather than formal names; for example, Venezuela rather than The Bolivarian Republic of Venezuela. We also distinguish among Communist China-Mainland and its two special administrative regions of China-Hong Kong and China-Macau. We refer to Taiwan as China-Taiwan. METHODOLOGY The contribution of medical devices and device coatings and surface treatment is well established in the professional literature. The types of materials and processes used to manufacture medical devices are likewise known from public record filings by those seeking governmental approval to market those devices. In addition, national governments maintain records describing the prevalence of diseases and injuries rates by age group, and healthcare system delivery characteristics, including physician density, hospitalization rates and healthcare costs. Examining data from those and other public sources using data-mining techniques has enabled BCC Research to constructed dollar values demand forecasts for 2012 through 2017 for medical device coatings and surface treatments based upon consensus estimates of changes in country populations and their respective economic growth factors. That country data is aggregated into four regions based upon the existence of trade pacts and per capita gross national incomes. INFORMATION SOURCES In addition to the public records identified in the previous section, BCC Research has studied the capabilities and patent filings of the companies and organizations mention in this study. BCC Research also reviewed reports and studies prepared by the chemical industry and organizations representing physicians, surgeons, hospital administrators, and trade and professional associations; foreign government trade associations; insurers and non-governmental organizations. ANALYST'S CREDENTIALS

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>> Get this Report Now by email! Technology analyst James Wilson prepared both the original 2006 version of this study, Medical Device Coating (HLC049A), and its 2008 revision (HLC049B). He is the author of more than 300 articles and several books dealing with science, medicine, technology and business. Formerly the editor of the Princeton Business Journal and a senior science and technology editor for Hearst Magazines, he is a past member of the National Association of Science Writers and American Medical Writers Association. He has served on the adjunct faculty of Temple University and on the staffs of Drexel University and the Academy of Natural Sciences. His related studies for BCC include MST027H Controlled Release Technologies: Established and Emerging Markets and HLC080A Medical Device Sensors: Technologies and Global Markets.

Table of Content TABLE OF CONTENTS CHAPTER ONE: INTRODUCTION 1 STUDY GOAL AND OBJECTIVES 1 REASONS FOR DOING THE STUDY

INTENDED AUDIENCE 2 SCOPE AND FORMAT

TECHNOLOGIES 2 HEALTHCARE AREAS 3 COUNTRIES AND REGIONS METHODOLOGY

INFORMATION SOURCES 4 ANALYST'S CREDENTIALS

RELATED BCC WORK CREDENTIALS 5 BCC ON-LINE SERVICES 5 DISCLAIMER

CHAPTER TWO: SUMMARY

SUMMARY 7 SUMMARY TABLE GLOBAL SIZE OF THE MEDICAL DEVICE COATING MARKET BY REGION, THROUGH 2017 ($ MILLIONS)

SUMMARY FIGURE GLOBAL REQUIREMENT FOR MEDICAL DEVICE COATINGS BY REGION, 2010-2017 ($ MILLIONS)

CHAPTER THREE: INDUSTRY OVERVIEW 9 INDUSTRY OVERVIEW 9 HOW COATINGS IMPROVE MEDICAL DEVICES

GLOBAL COATINGS AND TREATMENTS FORECASTS 10 TABLE 1 EUROPEAN UNION (EU) ZONE COUNTRIES: FULL MEMBERS AS OF MARCH 1, 2012 10 TABLE 1 (CONTINUED) 11 TABLE 2 OTHER DEVELOPED NATIONS: PER CAPITA GNI OF $12,276 AND ABOVE 11 TABLE 2 (CONTINUED) 12 TABLE 3 REST OF THE WORLD: PER CAPITA GNI OF $12,275 AND BELOW 12 TABLE 3 (CONTINUED) 13

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>> Get this Report Now by email! TABLE 3 (CONTINUED) 14 TABLE 3 (CONTINUED) 15 TABLE 4 GLOBAL COATING FORECAST BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 15 TABLE 4 (CONTINUED) 16 TABLE 5 GLOBAL COATING FORECAST BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS) 16 STANDARDIZATION AND HARMONIZATION

STANDARDIZATION AND HARMONIZATION (CONTINUED) 17 UNIVERSITY-BASED MEDICAL DEVICE COATING RESEARCH UNIVERSITY-BASED MEDICAL '(CONTINUED)

EFFECTS OF THE ECONOMIC SLOWDOWN (CONTINUED)

THE CHALLENGE TO ACA, THE NEW U S HEALTH INSURANCE LAW

TABLE 6 COMPARATIVE COSTS FOR IMPLANT PROCEDURES, 2010 ($) 22 THE CHALLENGE TO ACA, '(CONTINUED) 23 CHAPTER FOUR: MEDICAL DEVICE COATING PATENT ANALYSIS

TABLE 7 THE 500 MOST RECENTLY ISSUED PATENTS REFERENCING MEDICAL DEVICES AND COATINGS, AS OF MARCH 3, 2012 24 TABLE 7 (CONTINUED) 25 TABLE 7 (CONTINUED) 26 TABLE 7 (CONTINUED) 27 TABLE 7 (CONTINUED) 28 TABLE 7 (CONTINUED) 29 TABLE 7 (CONTINUED) 30 TABLE 7 (CONTINUED) 31 TABLE 7 (CONTINUED) 32 TABLE 7 (CONTINUED) 33 TABLE 7 (CONTINUED) 34 TABLE 7 (CONTINUED) 35 TABLE 7 (CONTINUED) 36 TABLE 7 (CONTINUED) 37 CHAPTER FIVE: THE COMMERCIAL SECTOR 38 HOW FDA RULES DEFINE MARKET PARTICIPANTS 38 TABLE 8 TYPES OF FDA RECOGNIZED ENTITIES 39 INDUSTRY ADVOCACY ORGANIZATIONS 40 TABLE 9 COUNTRIES THAT INCORPORATE DEVICE DEVELOPMENT INTO NATIONAL HEALTHCARE PLANNING AND POLICIES (BY COUNTRY) 40 TABLE 9 (CONTINUED) 41 COMMERCIAL PARTICIPANTS

DEVICE MANUFACTURERS 42 Abbott Laboratories 42 Abiomed 43 Bacterin International

Bacterin International (Continued) 45

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Biomet 46 Boston Scientific

BTG 48 C R Bard Inc 49 Cameron Health Inc

CardioTech International 50 Cook Medical Inc 51 Conor Medsystems

Cordis 51 Corin Group 52 Depuy Orthopaedics

Edwards Lifesciences 52 Japan Medical Materials 53 Johnson & Johnson 54 Kyocera Medical Corp 55 Lombard Medical Technologies 55 Medtronic 56 Micrus Endovascular 57 Orthopaedic Synergy 57 Smith & Nephew 57 St Jude Medical Stryker

Symmetry Medical

Thoratec 61 Wright Medical Group

Zimmer Holdings 63 COATING MANUFACTURERS 63 4th State Inc

Accord Biomaterials

AcryMed 64 Advansource Biomaterials 64 AeonClad Coating 65 Affinergy

Agion Technologies 66 Allvivo Vascular Inc

Angiotech Pharmaceuticals 67 Angiotech Pharmaceuticals (Continued) 68 Armoloy of Connecticut 69 AST Products 69 AST Products (Continued) 70 Bactiguard 71 Bayer MaterialScience 71 Biocoat 71 Biocompatibles International 72 Bristol-Myers Squibb 72 Cerac Covalon

72 73

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Sciessent 75 Spire Biomedical

Surface Solutions 77 SurModics 77 TYRX

W L Gore & Associates Inc

Williams Advanced Materials'Materion Corp 80 CHAPTER SIX: HOW THE FDA STRUCTURES THE GLOBAL MARKET 81 HOW THE FDA STRUCTURES THE GLOBAL MARKET 81 HOW THE FDA STRUCTURES THE '(CONTINUED)

FDA MEDICAL DEVICE REVIEW PANELS 83 TABLE 10 MEDICAL DEVICE REVIEW PANELS 84 BRINGING A MEDICAL DEVICE TO MARKET 84 CONTROL CLASS 85 TABLE 11 FDA REGULATORY CONTROLS 86 Class I Medical Devices 87 Class II Medical Devices 87 Class III Medical Devices 88 COMBINATION PRODUCTS 89 Combination Products (Continued)

TABLE 12 BIOABSORBABLE COATING MATERIALS 91 TABLE 13 ANTIBIOTIC MEDICAL DEVICE COATINGS (TRADEMARKED NAMES CAPITALIZED) 91 TABLE 13 (CONTINUED) 92 CHALLENGES TO CURRENT FDA CLEARANCE PRACTICES 92 ESTABLISHING SUBSTANTIAL EQUIVALENCE 93 Establishing ' (Continued)

FIGURE 1 510(K) 'SUBSTANTIAL EQUIVALENCE' DECISIONMAKING PROCESS 95 PROPOSED REFORMS TO THE 510(K) PROCESS 96 Proposed Reforms to the 510(k) Process (Continued) 97 Proposed Reforms to the 510(k) Process (Continued) 98 THE SAFETY OF UNTESTED AND NEW DEVICES ACT OF 2012

CHAPTER SEVEN: COATINGS AND SURFACE TREATMENT TECHNOLOGIES 100 ALLOY COATINGS DESCRIPTIONS AND FORECAST 100 TABLE 14 FORECAST FOR ALLOY COATINGS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS) 101 TYPES OF ALLOY COATINGS 102 Aluminum 102 Gold

102

Nitinol 103 Silver Compounds 103 Stainless Steel 104

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106

TABLE 15 FORECAST FOR CERAMIC COATINGS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS) 107 TYPES OF CERAMIC COATINGS Alumina

107

Bioglass

108

Carbon-Based

107

109

COMBINATION COATINGS DESCRIPTIONS AND FORECAST 110 TABLE 16 ACTIVE AGENTS AND CARRIERS USED IN COMBINATION PRODUCT COATINGS

111

TABLE 17 FORECAST FOR COMBINATION COATINGS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS) TABLE 17 (CONTINUED)

112

113

TYPES OF COMBINATION COATINGS 113 Bone Morphogenetic Protein 2

113

Cationic Steroid Antimicrobials 113 Collagen 114 Dexamethasone

114

Gore/Carmeda BioActive Surface Technology Heparin

115

Hyaluronan Hydrogels

116 116

Hydroxyapatite

116

Hydroxyapatite (Continued) 117 Medi-Coat Carrier Technology Nitric Oxide

118

Paclitaxel 118 Parylenes 119 Phosphorylcholine (PC Technology) 120 PolymerDrugs 121 Polyethylene 121 Sirolimus, Everolimus and Zotarolimus Stem Cell Coatings

122

123

ENERGY-ABSORBING COATINGS DESCRIPTIONS AND FORECASTS 123 TABLE 18 FORECAST FOR ENERGY-ABSORBING COATINGS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS)

124

TYPES OF ENERGY-ABSORBING COATINGS 125 Types of Energy-'(Continued) 126 ENERGY-EMITTING COATINGS DESCRIPTIONS AND FORECASTS 127 TABLE 19 FORECAST FOR ENERGY-EMITTING COATINGS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS) TABLE 19 (CONTINUED)

127

128

TYPES OF ENERGY-EMITTING COATINGS 128 Bioactive 128

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129

Galvanic 129 Radioactive 130 MICRO- AND NANO-COATINGS DESCRIPTIONS AND FORECASTS 131 TABLE 21 FORECAST FOR MICRO AND NANO COATINGS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS)

131

TYPES OF MATERIALS MICRO- AND NANO-MATERIALS 131 Types of Materials Micro- and ' (Continued) 132 PROTECTIVE POLYMER COATINGS DESCRIPTIONS AND FORECASTS 133 TABLE 22 LUBRICIOUS MEDICAL DEVICE COATINGS

134

PROTECTIVE POLYMER COATINGS '(CONTINUED) 135 TABLE 23 FORECAST FOR PROTECTIVE POLYMER COATINGS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS)

136

TYPES OF PROTECTIVE POLYMER COATINGS 136 Hexyl-PVP 136 PDMS poly(dimethyl siloxane)

137

Polyurethane 137 Polytetrafluoroethylene Teflon 137 Polyvinyl Chloride 138 SURFACE TREATMENT DESCRIPTIONS AND FORECASTS

138

TABLE 24 FORECAST FOR SURFACE TREATMENTS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS) TYPES OF SURFACE TREATMENTS

139

Direct Deposition Techniques 139 Plasma Techniques

140

Ion Implantation Techniques 141 Laser Activation 142 Texturing

142

TABLE 25 FORECAST FOR SURFACE TREATMENTS BY HEALTHCARE AREA, THROUGH 2017 ($ MILLIONS)

143

CHAPTER EIGHT: DEMAND BY HEALTHCARE AREAS 144 LEADING DEMAND INDICATORS 144 DISTRIBUTION OF PHYSICIANS 145 TABLE 26 DISTRIBUTION OF PHYSICIANS (NUMBER PER 1,000) TABLE 26 (CONTINUED)

145

146

TABLE 26 (CONTINUED) 147 VARIATIONS IN INJURY RATES

147

TABLE 27 LEADING INDICATORS: ROAD TRAFFIC DEATHS (PER 100,000 OF POPULATION) 147 TABLE 27 (CONTINUED)

148

TABLE 27 (CONTINUED)

149

TABLE 27 (CONTINUED)

150

TABLE 27 (CONTINUED)

151

TABLE 28 LEADING INDICATORS: PHYSICIAN DENSITY (PER 100,000 OF POPULATION) 152

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153

NATIONAL SPENDING ON HEALTHCARE 153 TABLE 29 LEADING INDICATORS: HEALTHCARE SPENDING, 2009 (PER CAPITA IN PPP INTERNATIONAL $) 154 TABLE 29 (CONTINUED)

155

TABLE 29 (CONTINUED)

156

TABLE 29 (CONTINUED)

157

TABLE 29 (CONTINUED)

158

AMERICAN BOOMERS ENTER THE MEDICARE YEARS 158 American Boomers Enter The ' (Continued) 159 TABLE 30 GLOBAL GROWTH IN OLDER POPULATIONS (% OF POPULATION AGE 65 OR OLDER IN 2017) 160 MEDICAL CONDITIONS AND THE ELDERLY 160 TABLE 31 MOST COMMON INPATIENT SURGICAL PROCEDURES FOR OLDER AMERICANS 161 TABLE 31 (CONTINUED)

162

ANESTHESIOLOGY FORECAST

162

TABLE 32 COATING FORECAST FOR ANESTHESIA DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 162 TABLE 33 ALLOY COATING FORECAST FOR ANESTHESIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 163 TABLE 34 CERAMIC COATING FORECAST FOR ANESTHESIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 163 TABLE 35 COMBINATION COATING FORECAST FOR ANESTHESIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 163 TABLE 36 ENERGY-ABSORBING COATING FORECAST FOR ANESTHESIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 164 TABLE 37 ENERGY-EMITTING COATING FORECAST FOR ANESTHESIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 164 TABLE 38 MICRO- AND NANO-COATING FORECAST FOR ANESTHESIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 164 TABLE 39 PROTECTIVE POLYMER COATING FORECAST FOR ANESTHESIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 165 TABLE 40 SURFACE TREATMENT FORECAST FOR ANESTHESIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 165 CARDIOVASCULAR FORECAST

165

CARDIOVASCULAR FORECAST'(CONTINUED) 166 CARDIOVASCULAR FORECAST'(CONTINUED) 167 TABLE 41 COATING FORECAST FOR CARDIOVASCULAR DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 168 TABLE 42 ALLOY COATING FORECAST FOR CARDIOVASCULAR DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 168

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177

TABLE 61 CERAMIC COATING FORECAST FOR DENTAL DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 177 TABLE 62 COMBINATION COATING FORECAST FOR DENTAL DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 177

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179

TABLE 67 SURFACE TREATMENT FORECAST FOR DENTAL DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 179 EAR, NOSE AND THROAT FORECAST 179 TABLE 68 COATING FORECAST FOR EAR, NOSE AND THROAT DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 180 TABLE 69 ALLOY COATING FORECAST FOR EAR, NOSE AND THROAT DEVICES BY REGION, THROUGH 2017 ($ MILLIONS)

180

TABLE 70 CERAMIC COATING FORECAST FOR EAR, NOSE AND THROAT DEVICES BY REGION, THROUGH 2017 ($ MILLIONS)

181

TABLE 71 COMBINATION COATING FORECAST FOR EAR, NOSE AND THROAT DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 181 TABLE 72 ENERGY-ABSORBING COATING FORECAST FOR EAR, NOSE AND THROAT DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 181 TABLE 73 ENERGY-EMITTING COATING FORECAST FOR EAR, NOSE AND THROAT DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 182 TABLE 74 MICRO- AND NANO-COATING FORECAST FOR EAR, NOSE AND THROAT DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 182 TABLE 75 PROTECTIVE POLYMER COATING FORECAST FOR EAR, NOSE AND THROAT DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 182 TABLE 76 SURFACE TREATMENT FORECAST FOR EAR, NOSE AND THROAT DEVICES BY REGION, THROUGH 2017 ($ MILLIONS)

183

GASTROENTEROLOGY AND UROLOGY FORECAST 183 TABLE 77 COATING FORECAST FOR GASTROENTEROLOGY AND UROLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 184 TABLE 78 ALLOY COATING FORECAST FOR GASTROENTEROLOGY AND UROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 184 TABLE 79 CERAMIC COATING FORECAST FOR GASTROENTEROLOGY AND UROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 185 TABLE 80 COMBINATION COATING FORECAST FOR GASTROENTEROLOGY AND UROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 185 TABLE 81 ENERGY-ABSORBING COATING FORECAST FOR

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>> Get this Report Now by email! GASTROENTEROLOGY AND UROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 185 TABLE 82 ENERGY-EMITTING COATING FORECAST FOR GASTROENTEROLOGY AND UROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 186 TABLE 83 MICRO- AND NANO-COATING FORECAST FOR GASTROENTEROLOGY AND UROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 186 TABLE 84 NANO- AND MICRO-COATING FORECAST FOR GASTROENTEROLOGY AND UROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 186 TABLE 85 SURFACE TREATMENT FORECAST FOR GASTROENTEROLOGY AND UROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 187 GENERAL AND PLASTIC SURGERY FORECAST 187 TABLE 86 COATING FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 188 TABLE 87 ALLOY COATING FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 188 TABLE 88 CERAMIC COATING FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 189 TABLE 89 COMBINATION COATING FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS)

189

TABLE 90 ENERGY-ABSORBING COATING FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 189 TABLE 91 ENERGY-EMITTING COATING FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS)

190

TABLE 92 MICRO- AND NANO-COATING FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS)

190

TABLE 93 PROTECTIVE POLYMER COATING FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 190 TABLE 94 SURFACE TREATMENT FORECAST FOR GENERAL AND PLASTIC SURGERY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 191 GENERAL HOSPITAL USE FORECAST

191

TABLE 95 AVERAGE LENGTH OF HOSPITAL STAY BY SEX AND AGE (DAYS)

191

TABLE 95 (CONTINUED)

192

TABLE 96 COATING FORECAST FOR GENERAL HOSPITAL USE DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 192

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>> Get this Report Now by email! TABLE 97 ALLOY COATING FORECAST FOR HOSPITAL USE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 193 TABLE 98 CERAMIC COATING FORECAST FOR HOSPITAL USE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 193 TABLE 99 COMBINATION COATING FORECAST FOR HOSPITAL USE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 193 TABLE 100 ENERGY-ABSORBING COATING FORECAST FOR HOSPITAL USE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 194 TABLE 101 ENERGY-EMITTING COATING FORECAST FOR HOSPITAL USE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 194 TABLE 102 MICRO- AND NANO- COATING FORECAST FOR HOSPITAL USE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 194 TABLE 103 PROTECTIVE POLYMER COATING FORECAST FOR HOSPITAL USE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 195 TABLE 104 SURFACE TREATMENT FORECAST FOR HOSPITAL USE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 195 HEMATOLOGY FORECAST 195 TABLE 105 COATING FORECAST FOR HEMATOLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 196 TABLE 106 ALLOY COATING FORECAST FOR HEMATOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 196 TABLE 107 CERAMIC COATING FORECAST FOR HEMATOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 197 TABLE 108 COMBINATION COATING FORECAST FOR HEMATOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 197 TABLE 109 ENERGY-ABSORBING COATING FORECAST FOR HEMATOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 197 TABLE 110 ENERGY-EMITTING COATING FORECAST FOR HEMATOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 198 TABLE 111 NANO- AND MICRO-COATING FORECAST FOR HEMATOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 198 TABLE 112 PROTECTIVE POLYMER COATING FORECAST FOR HEMATOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 198 TABLE 113 SURFACE TREATMENTS FORECAST FOR HEMATOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 199 IMMUNOLOGY FORECAST 199 TABLE 114 COATING FORECAST FOR IMMUNOLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 200

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>> Get this Report Now by email! TABLE 115 ALLOY COATING FORECAST FOR IMMUNOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 200 TABLE 116 CERAMIC COATING FORECAST FOR IMMUNOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 201 TABLE 117 COMBINATION COATING FORECAST FOR IMMUNOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 201 TABLE 118 ENERGY-ABSORBING COATING FORECAST FOR IMMUNOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 201 TABLE 119 ENERGY-EMITTING COATING FORECAST FOR IMMUNOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 202 TABLE 120 MICRO- AND NANO-COATING FORECAST FOR IMMUNOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 202 TABLE 121 PROTECTIVE POLYMER COATING FORECAST FOR IMMUNOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 202 TABLE 122 SURFACE TREATMENTS FORECAST FOR IMMUNOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 203 MICROBIOLOGY FORECAST 203 TABLE 123 COATING FORECAST FOR MICROBIOLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 204 TABLE 124 ALLOY COATING FORECAST FOR MICROBIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 204 TABLE 125 CERAMIC COATING FORECAST FOR MICROBIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 205 TABLE 126 COMBINATION COATING FORECAST FOR MICROBIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 205 TABLE 127 ENERGY-ABSORBING COATING FORECAST FOR MICROBIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 205 TABLE 128 ENERGY-EMITTING COATING FORECAST FOR MICROBIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 206 TABLE 129 MICRO- AND NANO-COATING FORECAST FOR MICROBIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 206 TABLE 130 PROTECTIVE POLYMER COATING FORECAST FOR MICROBIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 206 TABLE 131 SURFACE TREATMENT FORECAST FOR MICROBIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 207 NEUROLOGY FORECAST 207

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>> Get this Report Now by email! TABLE 132 COATING FORECAST FOR NEUROLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 208 TABLE 133 ALLOY COATING FORECAST FOR NEUROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 208 TABLE 134 CERAMIC COATING FORECAST FOR NEUROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 209 TABLE 135 COMBINATION COATING FORECAST FOR NEUROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 209 TABLE 136 ENERGY-ABSORBING COATING FORECAST FOR NEUROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 209 TABLE 137 ENERGY-EMITTING COATING FORECAST FOR NEUROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 210 TABLE 138 MICRO- AND NANO-COATING FORECAST FOR NEUROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 210 TABLE 139 PROTECTIVE POLYMER COATING FORECAST FOR NEUROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 210 TABLE 140 SURFACE TREATMENT FORECAST FOR NEUROLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 211 OBSTETRICS AND GYNECOLOGY FORECAST 211 TABLE 141 COATING FORECAST FOR OBSTETRICS AND GYNECOLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 212 TABLE 142 ALLOY COATING FORECAST FOR OBSTETRICS AND GYNECOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 212 TABLE 143 CERAMIC COATING FORECAST FOR OBSTETRICS AND GYNECOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 213 TABLE 144 COMBINATION COATING FORECAST FOR OBSTETRICS AND GYNECOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 213 TABLE 145 ENERGY-ABSORBING COATING FORECAST FOR OBSTETRICS AND GYNECOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 213 TABLE 146 ENERGY-EMITTING COATING FORECAST FOR OBSTETRICS AND GYNECOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 214 TABLE 147 MICRO- AND NANO-COATING FORECAST FOR OBSTETRICS AND GYNECOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 214 TABLE 148 PROTECTIVE POLYMER COATING FORECAST FOR OBSTETRICS AND GYNECOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 214 TABLE 149 SURFACE TREATMENT FORECAST FOR OBSTETRICS

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>> Get this Report Now by email! AND GYNECOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 215 OPHTHALMOLOGY FORECAST

215

TABLE 150 COATING FORECAST FOR OPHTHALMOLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 216 TABLE 151 ALLOY COATING FORECAST FOR OPHTHALMOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 216 TABLE 152 CERAMIC COATING FORECAST FOR OPHTHALMOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 217 TABLE 153 COMBINATION COATING FORECAST FOR OPHTHALMOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 217 TABLE 154 ENERGY-ABSORBING COATING FORECAST FOR OPHTHALMOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 217 TABLE 155 ENERGY-EMITTING COATING FORECAST FOR OPHTHALMOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 218 TABLE 156 MICRO- AND NANO-COATING FORECAST FOR OPHTHALMOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 218 TABLE 157 PROTECTIVE POLYMER COATING FORECAST FOR OPHTHALMOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 218 TABLE 158 SURFACE TREATMENT FORECAST FOR OPHTHALMOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 219 ORTHOPEDIC FORECAST 219 TABLE 159 COATING FORECAST FOR ORTHOPEDIC DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 220 TABLE 160 ALLOY COATING FORECAST FOR ORTHOPEDIC DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 220 TABLE 161 CERAMIC COATING FORECAST FOR ORTHOPEDIC DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 221 TABLE 162 COMBINATION COATING FORECAST FOR ORTHOPEDIC DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 221 TABLE 163 ENERGY-ABSORBING COATING FORECAST FOR ORTHOPEDIC DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 221 TABLE 164 ENERGY-EMITTING COATING FORECAST FOR ORTHOPEDIC DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 222 TABLE 165 MICRO- AND NANO-COATING FORECAST FOR ORTHOPEDIC DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 222 TABLE 166 PROTECTIVE POLYMER COATING FORECAST FOR ORTHOPEDIC DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 222

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>> Get this Report Now by email! TABLE 167 SURFACE TREATMENT FORECAST FOR ORTHOPEDIC DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 223 PATHOLOGY FORECAST

223

TABLE 168 COATING FORECAST FOR PATHOLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 224 TABLE 169 ALLOY COATING FORECAST FOR PATHOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 224 TABLE 170 CERAMIC COATING FORECAST FOR PATHOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 225 TABLE 171 COMBINATION COATING FORECAST FOR PATHOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 225 TABLE 172 ENERGY-ABSORBING COATING FORECAST FOR PATHOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 225 TABLE 173 ENERGY-EMITTING COATING FORECAST FOR PATHOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 226 TABLE 174 NANO- AND MICRO COATING FORECAST FOR PATHOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 226 TABLE 175 PROTECTIVE POLYMER COATING FORECAST FOR PATHOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 226 TABLE 176 SURFACE TREATMENT FORECAST FOR PATHOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 227 PHYSICAL MEDICINE FORECAST 227 TABLE 177 COATING FORECAST FOR PHYSICAL MEDICINE DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 228 TABLE 178 ALLOY COATING FORECAST FOR PHYSICAL MEDICINE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 228 TABLE 179 CERAMIC COATING FORECAST FOR PHYSICAL MEDICINE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 229 TABLE 180 COMBINATION COATING FORECAST FOR PHYSICAL MEDICINE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 229 TABLE 181 ENERGY-ABSORBING COATING FORECAST FOR PHYSICAL MEDICINE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 229 TABLE 182 ENERGY-EMITTING COATING FORECAST FOR PHYSICAL MEDICINE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 230 TABLE 183 MICRO- AND NANO-COATING FORECAST FOR PHYSICAL MEDICINE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 230 TABLE 184 PROTECTIVE POLYMER COATING FORECAST FOR PHYSICAL MEDICINE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 230 TABLE 185 SURFACE TREATMENT FORECAST FOR PHYSICAL MEDICINE DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 231

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>> Get this Report Now by email! RADIOLOGY FORECAST 231 TABLE 186 COATING FORECAST FOR RADIOLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 232 TABLE 187 ALLOY COATING FORECAST FOR RADIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 232 TABLE 188 CERAMIC COATING FORECAST FOR RADIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 233 TABLE 189 COMBINATION COATING FORECAST FOR RADIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 233 TABLE 190 ENERGY-ABSORBING COATING FORECAST FOR RADIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 233 TABLE 191 ENERGY-EMITTING COATING FORECAST FOR RADIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 234 TABLE 192 MICRO- AND NANO-COATING FORECAST FOR RADIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 234 TABLE 193 PROTECTIVE POLYMER COATING FORECAST FOR RADIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 234 TABLE 194 SURFACE TREATMENT FORECAST FOR RADIOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 235 TOXICOLOGY FORECASTS 235 TABLE 195 COATING FORECAST FOR TOXICOLOGY DEVICES BY TECHNOLOGY, THROUGH 2017 ($ MILLIONS) 236 TABLE 196 ALLOY COATING FORECAST FOR TOXICOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 236 TABLE 197 CERAMIC COATING FORECAST FOR TOXICOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 237 TABLE 198 COMBINATION COATING FORECAST FOR TOXICOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 237 TABLE 199 ENERGY ABSORBING COATINGS FORECAST FOR TOXICOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 237 TABLE 200 ENERGY-EMITTING COATING FORECAST FOR TOXICOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 238 TABLE 201 MICRO- AND NANO-COATINGS FORECAST FOR TOXICOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 238 TABLE 202 PROTECTIVE POLYMER COATING FORECAST FOR TOXICOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 238 TABLE 203 SURFACE TREATMENT FORECAST FOR TOXICOLOGY DEVICES BY REGION, THROUGH 2017 ($ MILLIONS) 239 APPENDIX ABSTRACTS OF SIGNIFICANT COATING PATENTS

240

ABSTRACTS OF SIGNIFICANT COATING PATENTS 240 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 241 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 242 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 243 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 244

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>> Get this Report Now by email! ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 245 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 246 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 247 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 248 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 249 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 250 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 251 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 252 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 253 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 254 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 255 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 256 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 257 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 258 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 259 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 260 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 261 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 262 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 263 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 264 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 265 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 266 ABSTRACTS OF SIGNIFICANT ' (CONTINUED) 267

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