NUDT15 Nudix Hydrolase 15

• Mutations in NUDT15 are associated with poor metabolism of thiopurines and increased risk of myelosuppression

LGC Clinical Diagnostics announced the addition of Cystatin C to Maine Standards Validate diabetes kit for the Roche cobas platforms for easy, fast, reliable documentation of linearity and calibration eri cation e product it t e analyte eta ydro ybutyrate eptide n ulin ructo amine and no y tatin i ormulated in uman erum u in t e E equal delta ample preparation met od and pro ide e di tinct concentration alidate diabete te t it are frozen liquid and ready to use – dispense the solution from eac dropper bottle directly into e ample cup and run in replicates to verify the assay’s reportable range. lgcgroup.com

• c.415C>T mutation associated with NUDT15*2 and NUDT15*3 haplotypes

• Increased prevalence of c.415C>T mutation in Asian populations

• Recommended that NUDT15 genotyping is performed prior to initiation of thiopurine drugs (ALLtogether guidelines)

• Analysis performed by real-time polymerase chain reaction (RT-PCR) rajvindergarcha@nhs.net www.bcpathology.org.uk

0121 507 5348

Clinical Biochemistry, City Hospital

Dudley Road, Birmingham B18 7QH

@BCPathology BCPathology

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