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William Harvey Day Programme Tuesday 26 October 2010 St Bartholomew’s Hospital, West Smithfield, London
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Welcome to William Harvey Day
William Harvey Day will showcase some of the best cutting edge research currently underway in Barts and the London, School of Medicine and Dentistry and in our partner NHS Trusts. There will be nine presentations by School researchers, as well as three science “hot topics” presented by leading researchers who have recently joined the School, and three guest lectures. We are delighted that these will be given by Sir Tim Hunt FRS, Nobel Laureate and principal researcher at the Cancer Research UK Clare Hall Laboratories, Professor Sir Mark Walport, Director of the Wellcome Trust and Professor Marcus du Sautoy, Professor for the Public Understanding of Science and Professor of Mathematics at the University of Oxford. The day will conclude with the Barts and The London NHS Trust’s traditional annual St Luke’s-tide Service in the church of St Bartholomew the Great. I would be delighted if you were able to attend the Service, as this is a traditional and very enjoyable part of the day.
Professor Sir Nicholas Wright Warden, Barts and The London, School of Medicine and Dentistry
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Venue information
The Great Hall and Pathology The Butchers’ Hall If you have booked to attend the subscription Museum dinner, this will take place at the Butchers’ Hall, 87 The event registration desk is located just inside the main entrance to the Great Hall and a cloakroom is also available here. Coffee and Lunch will be served in two separate venues; the Great Hall and the Pathology Museum (located in the Pathology Building). Posters will also be displayed in both venues. To ensure you can view all posters and prevent overcrowding in each venue, the front of this programme indicates which venue you should attend for the morning coffee break and lunch.
Robin Brook Centre All lectures and oral presentations will be taking place in the Morris Lecture Theatre which is situated in the Robin Brook Centre. Please note that once the lecture theatre is full, you will be directed to either the Patterson Ross or Bainbridge Room where the sessions can be watched on a big-screen.
St. Bartholomew the Great The St. Luke’s-tide service will take place in the church of St Bartholomew the Great at 6.00pm which is located 2 minutes walk from St Bartholomew’s Hospital. If you are joining the academic procession, your gown will be available in the Great Hall from 5.00pm onwards.
04 Queen Mary, University of London
Bartholomew Close. This is around 2 minutes walk from the hospital and is shown on the map at the rear of this programme.
CPD Approval William Harvey Day is accredited for CPD. In order to claim the credits, you will need to sign the CPD register in the foyer area of the Great Hall. Certificates will be available at the end of the day.
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Programme
8:30 Registration (Great Hall entrance foyer)
09:55 Year 1 Medical Student Research Project Prizewinner
Coffee/Tea and poster display (Great Hall) Posters will be in the Great Hall and Pathology Museum for viewing throughout the Day 8:50 Welcome and Introduction – Professor Sir Nicholas Wright, Warden, Barts and The London School of Medicine and Dentistry
Session 1 – chaired by Professor Graham Hitman 08:55 Hot Topic in Science ‘Flip-flops are best when paddling in Bile’ Professor Kenny Linton, Blizard Institute of Cell and Molecular Science 9:10 Oral presentations ‘Use of preclinical FDG-PET to predict outcome in response to anti-angiogenic therapy in two mouse models of metastatic cancer’ Julie Foster, Institute of Cancer ‘Breakage of B cell tolerance by antigens on follicular dendritic cells’ Mohey El Shikh, William Harvey Research Institute ‘Mutations in C16orf57 and normal length telomeres unify a subset of patients with dyskeratosis congenita, poikiloderma with neutropenia and Rothmund-Thomson syndrome’ Amanda Walne, Blizard Institute of Cell and Molecular Science
‘The present and future of osteoarthritis’ Rafae Shaikh 10:05 Sir Anthony Dawson Lecture ‘How to avoid futile cycles: A new element in the control of mitosis’ Sir Tim Hunt FRS Nobel Laureate 2001, CRUK Laboratories (Introduced by Professor Sir Nicholas Wright) 10:50 Coffee and poster viewing (Great Hall & Pathology Museum) Please refer to the front of this programme which indicates which venue you should attend.
Session 2 – chaired by Professor Mike Curtis 11:20 Hot Topic in Science ‘Unraveling the transport requirements of cargo waiting to leave the endoplasmic reticulum’ Professor Carol Shoulders , William Harvey Research Institute 11:35 Oral presentations ‘The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cutaneous squamous cell carcinoma’ Monika Cichon, Blizard Institute of Cell and Molecular Science Queen Mary, University of London 05
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Programme (cont)
‘Effect of folic acid on cognitive decline: meat analysis of randomised trials’ Mark Simmonds, Wolfson Institute
Session 3 - chaired by Professor Nick Lemoine
‘The use of “Cell Sheet” technique enhances the therapeutic effects of skeletal myoblast transplantation with elimination of arrhythmogenicity’ Takuya Narita, William Harvey Research Institute
14:30 Hot Topic in Science ‘Evaluating tests in the absence of gold standard’ Professor Khalid Khan, Institute of Health Sciences Education
12:20 Year 1 Medical Student Research Project Prizewinner
14:45 Oral presentations
‘Anti-Platelet Treatment in Non-ST-ElevatedMyocardial Infarction’ Nadia Taylor
‘Macrophage ablation retards progression of an aggressive mouse Lymphoma’ Simon Hallam, Institute of Cancer
12:30 William Harvey Lecture
‘Management of Cardiovascular multimorbidity’ Sally Hull and Rohini Mathur, Institute of Health Sciences Education
‘A century of inborn errors in metabolism: From Garrod to genomics’ Professor Sir Mark Walport, Director, Wellcome Trust (introduced by Professor Rod Flower) 13:15-14:30 Lunch and poster viewing (Great Hall and Pathology Museum) Please refer to the front of this programme which indicates which venue you should attend for lunch. 13:15 Alumni Association AGM and Lunch (Peggy Turner Room)
‘Dengue virus replicon inhibits responses to Lipopolysaccharide: Insight into a novel function for Stat2?’ William Alazawi, Blizard Institute of Cell and Molecular Science 15:30 Schorstein Lecture ‘The Secret Mathematicians’ Professor Marcus du Sautoy, Charles Simonyi Professor for the Public Understanding of Science and Professor of Mathematics, University of Oxford (introduced by Professor Mike Curtis) 16:20 Prize giving for oral presentations and posters. Professor Sir Nicholas Wright
06 Queen Mary, University of London
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16:30 The vision for the School of Medicine and Dentistry Professor Sir Nicholas Wright 16:40 Afternoon Tea and Refreshments (Great Hall) Academics joining the procession to St Bartholomew the Great are requested to collect their pre-booked robes from the Great Hall by 17.30.
The School is very grateful to the Barts and the London Charity for their support for the day. Our thanks to Fulvio D’Acquisto and David Bulmer who have very kindly agreed to judge the oral presentations, and Patsy Munroe, Andy Stagg, Matthias Dittmar and Pedro Cutillas who are judges for the poster display.
17:50 Academic procession leaves the North Wing 18:00 St Luke’s Tide Service (St. Bartholomew the Great) The address will be given by the Rev’d Professor Bernard Silverman FRS, Chief Scientific Advisor to the Home Office, and the lessons will be read by Professor Sir Nicholas Wright, Warden, and Dr Steve Ryan, Medical Director, Barts and The London NHS Trust. 19.15 Pre-Dinner drinks reception (Butchers’ Hall) 19:45 Dinner (Butchers’ Hall) Grace will be said by Rev'd Professor Nick Goulding. After dinner speech by the Warden, Professor Sir Nicholas Wright, and a response on behalf of the guests.
Queen Mary, University of London 07
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Poster Presentations – Great Hall
All posters will be displayed in the Great Hall and Pathology Museum from 8.30am until 2.30pm.
Barts and The London NHS Trust
7 An interpretative phenomenological analysis of the psychosocial impact of HIV-drug resistance in a group of gay men. Dr Dimitri Spiliotis
1 Contrast Enhanced Aortic Duplex UltraSonography Scanning (CEADUSS). Mr Shiva Dindyal
8 Diffusion Weighted MR Imaging in the Detection of Pancreatic Neuroendocrine Tumours. Dr Chirag Patel
2 Outcomes of a pilot roup using Mindfulness-Based Cognitive Therapy (MBCT) for people living with HIV and recurrent depression. Samantha Leaity
9 Accuracy of main-stream end-tidal carbon dioxide measurement during stabilisation and road transport of mechanically-ventilated preterm infants with respiratory distress syndrome in the first 48 hours of life. Adel Abdelhamid
3 Electronic Cytotoxic chemotherapy prescribing reduces prescription errors and improves cancer patient safety. Dr Fiona McCarthy 4 Who believes in oral HIV point of care tests? A summary of 3 years experience and more than 2000 OraQuick rapid tests. Nigel Garrett 5 A new, highly efficient Aspergillus-specific PCR; DNA detection from histological material and broncho-alveolar lavage fluid of infected patients. Gemma Johnson 6 Can Apparent Diffusion Coefficient (ADC) Predict Tumour Grade in Endometrial Carcinoma (EC)? Dr Nishat Bharwani
08 Queen Mary, University of London
10 Occult hyperfibrinolysis in trauma - a hidden killer. Imran Raza 11 Evaluation of acute rehabilitation needs for patients with traumatic injuries. Mrs Karen Hoffman 12 Trauma associated cardiac injury and dysfunction. Henry De'Ath
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The Blizard Institute of Cell and Molecular Science 13 Exome sequencing identifies thousands of novel candidate mutations in coeliac disease. Vanisha Mistry 14 Avoidance of vitamin D deficiency in pregnancy: the case for a unified approach in National policy. Barbara Boucher 15 Promoting the survival, migration and integration of Schwann cells after transplantation into spinal cord by overexpression of polysialic acid. Juan Luo 16 A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Sreeram Ramagopalan 17 Flow cytometric functional assays. Gary Warnes 18 The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation. Roberto Pineiro Cid 19 Development of a easy to use Super-Resolution Light Microscopy method for visualising biological structures at 50nm resolution and below. Dr A Wheeler
20 A study of psychophysiological responses to visceral & somatic pain in functional chest pain – a case control study. Adam Farmer 21 Loss of type VII collagen in SCC increases cell invasion through TGF-beta signalling. Vera Martins 22 Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. Tania Maffucci 23 Oesophageal epithelial ASIC3 is associated with increase in severity of symptoms in patients with gastro-oesophageal reflux disease (GORD). Yang Chua 24 Do Fas modified drug-loaded microspheres treat a paclitaxel resistant cell line? Nader Ibrahim 25 Early growth response gene – 2 (Egr-2) is an tumour suppressor gene. Tizong Miao 26 Personal exposure to back carbon in East London. Miss Clare Ewin 27 Frequent co-existence of constipation and faecal incontinence: a greatly underappreciated clinical problem. Sahar Mohammed
Queen Mary, University of London 09
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Poster Presentations – Great Hall (cont)
28 IL-7 and T cell receptor signals coordinately regulate γδ cell pre-programming and lymph node IL-17 production. Dr John Pang
36 Infliximab therapy alters antigen presenting cell population dynamics in Crohn’s disease. Dr Neil McCarthy
29 Phenotyping visceral pain in humans using functional brain imaging introduction. Steven Coen
37 The PcG gene Bmi1 regulates satellite cells function in young, aged and myopathic skeletal muscles. Valentina Di Foggia
30 The effects of eicosapentaenoic acid delivered as dietary treatment after spinal cord injury. Jodie Hall
38 Isolation and characterization of neural stem cells from the postnatal cerebellum. Dario Ceric
31 Gender differences in brain activity evoked by visceral pain in healthy subjects. Michiko Kano
39 Barrett’s oesophagus glands are clonal, contain multiple stem cells, expand by fission and share a common progenitor with the surrounding squamous epithelium. Anna Nicholson
32 Analysis of the molecular mechanisms mediating Bmi1 function in satellite cells. Xinyu Zhang 33 The clonal origins of dysplasia from intestinal metaplasia in the human stomach. Dr Stuart McDonald 34 Switching between two distinct cancer stem cell phenotypes in squamous cell carcinoma. Adrian Biddle 35 Is there altered somatosensory processing of nociception in a mouse model of multiple sclerosis. Saira Siddiqui
10 Queen Mary, University of London
40 20-HETE exhibits two phosphorylation-dependent actions on TRPV1. Hairuo Wen 41 A novel and selective PDK1 inhibitor reduces breast cancer cell invasion and tumour growth. Claudio Raimondi 42 Investigation of mechanisms regulating PI3K/p110γ expression in pancreatic cancer. Richard Buus
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43 The utility of T cell receptor-like antibodies to target HBV infected cells: the first steps towards individualised therapies for the treatment of chronic HBV infection. Li Li 44 The uptake of microspheres by breast cancer cells: improved delivery of chemotherapeutic agents. Mustafa Kadam 45 An in vitro study of the potential stromal role in basal cell carcinoma development through the investigation of GLI1 expression in basal cell carcinoma derived fibroblasts. Jane Elliott 46 The oncoprotein GLI1 induces an irreversible basal-like phenotype that confers androgen independence upon LNCaP prostate cancer cells. Sandeep Nadendla 47 Interferon-alpha mediates restriction of human immunodeficiency virus type-1 replication in primary human macrophages at an early postentry stage of replication. Kelly Cheney 48 Bmi1overexpression induces apoptotic death of neural progenitors during embryonic neocortex development through downregulation of Survivin. Serena Acquati 49 The effects of Omega-3 polyunsaturated fatty acids on cell survival after injury in vitro. Stacy Gladman
50 Characterising the steroid enzymes for endogenous cortisol synthesis in primary human keratinocytes. Adil Jaulim 51 Neural Stem Cells as therapeutic targets in Germinal Matrix Haemorrhage. William Dawes 52 Retinoic acid metabolising blocking agents increase differentiation in squamous cell carcinoma with loss of type VII collagen. Malcolm Avari 53 Critical role of NaV 1.9 in the activation of visceral sensory nerve fibres by bradykinin but not adenosine. David Bulmer 54 Validation of a new method for the assessment of vascular endothelial function. Santron Sathasivam 55 Gene Expression Profile during Progression from Premalignant to Cutaneous Squamous Cell Carcinoma. Nikol Mladkova 56 Morphometric analysis of the remyelinated sciatic nerve after injury in knock-out C/EBPδ mice. Hasanein Al-Hasani 57 DNA methylation across generations. Michelle Holland Queen Mary, University of London 11
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Poster Presentations – Great Hall (cont)
58 Quantifying remyelination using high field (9.4T) magnetic resonance imaging. Dr Shoaib Ugradar
65 EGR2 regulates inflammatory plasticity of effector T Cells. Meera Raymond
59 High-throughput sequencing-based DNA Methylomics. Guillermo Carbajosa
66 iASPP involvement in DNA repair in melanoma. Valentina Senatore
60 Different abilities of motilin and the motilin receptor agonist GSK962040 to facilitate cholinergic and nitrergic activity in human isolated stomach. Dr John Broad 61 Bactericidal activity release profiles generated in static biofilms are heterogeneous amongst different strains of Pseudomonas aeruginosa. Richard Waite 62 In vitro modelling of Basal Cell Carcinoma reveals a novel PTCH1-GLI1 signalling axis that is independent of SMOOTHENED in human keratinocytes. Muhammad Rahman 63 Modulation of adipose core clock component expression in genetic obesity by metformin. Paul Caton 64 ABCA12: a regulator of LXR-β mediated ABCA1 expression. Daniel Poon
12 Queen Mary, University of London
67 Urinary free light chain excretion in primary progressive multiple sclerosis. Dr Ruth Dobson 68 Asymptomatic Non Chlamydial Non Gonococcal Urethritis in men is associated with high sexual risk taking behaviours: Symptom based triage misses men at high risk for sexually transmitted infections. John Saunders 69 iASPP/p63 auto-regulatory feedback loop is essential for epithelial integrity and autophagy. Anissa Chikh 70 Clinical Trial: Influence of bovine colostrum on intestinal permeability in healthy athletes after heavy exercise. Tania Marchbank 71 Fingolimod enhances markers of remyelination in rat telencephalon spheroid cell culture. Samuel Jackson 72 Understanding the tumour-suppressing activity of rapamycin in epidermis. Katherine Sully
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73 Functional evidence for a protective effect against HIV-1 and Mycobacterium tuberculosis (Mtb) infection from the Toll-Like Receptor (TLR)-8 single nucleotide polymorphism (rs3764880). David van Bockel
80 Effects of the immuno-suppressive rapamycin on epidermis. Olufolake Akinduro
74 Factors within human inflamed intestinal mucosa uncouple lymphocyte imprinting and regulatory T cell generation by dendritic cells. Theo Sanders
81 Prospective randomized double-blind placebocontrolled crossover study of sacral nerve stimulation in patients with severe rectal evacuatory dysfunction allied to rectal hyposensitivity. Mr Noel Thin
75 Organ specific autoantibodies in patients with adult onset diabetes. Mohammed Hawa
82 Oxidative stress and senescence of balding dermal papilla cells. Jamie Upton
76 Senescence in human Basal Cell Carcinoma. Muhammad Pirzado
83 Early thymic T Cell Receptor signal initiation is independent of receptor oligomerization. Joana Neves
77 Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down Syndrome. Claudia Canzonetta 78 A day at the mosque: finding culturally appropriate ways to engage people in diabetes research by the North East London Diabetes Research Network. Gillian Hood 79 Towards an understanding of the link between the lipid floppase ABCB4 and the lipid flippase ATP8B1 in the canalicular membrane of the hepatocyte. Michael Nicolaou
84 VZV replication and its association with keratin 15 expression and Wnt signalling. Manuraj Singh 85 Homeodomain transcription factors Pbx and Pknox regulate location-specific epidermal barriers via differential expression of LCE barrier genes. Stuart Brown 86 The DSPII splice variant is critical for desmosomemediated HaCaT keratinocyte adhesion. Dan Tattersall
Queen Mary, University of London 13
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Poster Presentations – Great Hall (cont)
87 Phospholipase C signalling in cutaneous squamous cell carcinoma. Emily Ruban 88 Tissue damage activates an inflammatory response in trauma. Joanna Manson 89 Neutralisation activity in a geographically diverse East London cohort of HIV-1 infected patients: Clade C infection results in a stronger and broader humoral immune response than clade B infection. Hanna Dreja 90 Clonal evolution in Barrett’s oesopgagus determined by genetic diversity. Mr Shabuddin Khan 91 Assessing the feasibility of a new method for the non-invasive measurement of endothelial function in conduit arteries. Miss Amandeep Mukal
94 The tumour suppressor PTCH1 regulates EGFR signalling in human keratinocytes: implications for the treatment of basal cell carcinoma. Dimalee Herath 95 A model of intrauterine hyperglycaemia provides evidence for fetal programming of glucose tolerance and a platform for epigenomic studies in mouse and human. Sarah Finer 96 Identification of DNA methylation, histone modifications and gene expression differences in MZ twins. Carolina Gemma 97 Post entry restriction of MLV-B and MLV-NB capsids in human cells is envelope dependent. Nidia Oliveira 98 Identification of novel imprinted genes in humans. Lisa Nanty
92 Induction of cellular senescence by miRNA cooperation? Cleo Bishop
99 Using Next-Generation Sequencing to Identify Novel Disease Genes. Diana Blaydon
93 Monozygotic twins discordant for MS and discordant for serology disprove cytomegalovirus infection implication in MS. Monica Calado Marta
100 Retinoic acid and aryl hydrocarbon receptor signalling exert opposing effects on differentiation of human dendritic cells (DC) and their ablilty to imprint intestinal homing. Nichola Gellatly
14 Queen Mary, University of London
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101 Circulating ‘gut-tropic’ Vδ2 T-cells are altered in Crohn’s disease patients and their siblings. Charlotte Hedin
108 Maternal Vitamin D Deficiency in Tower Hamlets PCT. Ameana Khan
102 Genetic dissection of trisomy 21 pathology using transchromosomic cellular modelling. Dean Nizetic
109 Progress on progress testing: Barts and the London’s initial experience of the UK Multi-School Progress Testing Project. Patricia Revest and John Patterson
103 Can an ex vivo human liver biopsy model be used to test the efficacy of drugs for the treatment of hepatitis C? Alia Javaid
110 Prescribing for Chronic Obstructive Pulmonary Disorder in general practice: exploring health inequalities by ethnicity, sex and age. Alice Martin
104 Quantitative-PCR analysis of Fusobacterium nucleatum associated with adverse pregnancy outcomes. Cecilia Gonzales-Marin
111 How do student’s best learn anatomy? Exploring student’s responses to the resources available. Mohammed Bajalan
105 Inherited predisposition of oesophageal diseases (IPOD): A Genome Wide Association Study of Barrett’s Oesophagus. Laura Gay
112 What are the attitudes of young people from ethnic minorities towards mental illness in different areas of London? Maryam Zulafkar
106 Nano-antigen presenting cells (Nano-APC) for the development of therapeutic vaccines. Mengya Liu
113 Knowledge and understanding of HIV, AIDS and STD among adolescents in Hamburg, South Africa. Dr Jeannette Naish
Institute of Health Sciences Education 107 Adverse events and manual therapy: A systematic review. Dawn Carnes
114 Evaluation of a practice based intervention to reduce health inequalities in chronic disease management. Ellena Badrick
Queen Mary, University of London 15
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Poster Presentations – Great Hall (cont)
115 Back pain Reporting Outcomes Consensus (BaROC): a modified Delphi study. Robert Froud
122 Plagiarism: A study exploring the perceptions of students and staff. Sinthuja Jeyarajah
116 Collaborative working and UK NHS secondary care for Chronic Obstructive Pulmonary Disease: impact of the UK National COPD Resources and Outcomes Project (NCROP) model of peer review. Carol Rivas
123 Carbon content of airway macrophages and lung function in children within the London low emission zone (LEZ). Thomas Round
117 Does prior exposure to clinical practice enhance procedural learning in simulation training? Rumman Ahmed 118 Drug effectiveness at controlling type 2 diabetes by ethnicity and social deprivation. Gareth James 119 An evaluation of the relationship between Vitamin D status and quadriceps strength in patients with COPD : a cross sectional study. Jonathan Fenn 120 Identifying intimate partner violence in different ethnic groups in primary care. Alex Sohal 121 Attendance and non-attendance at selfmanagement courses. Dr Sharmin Shajahan
16 Queen Mary, University of London
124 Evaluating Doctors as teachers & educators – Does doing DATE as a student make a difference to teaching practice after qualification? Faiz Anwar 125 The representation of Government strategy and risk concerning the swine flu vaccine in UK newspapers during the pandemic period of April 2009 to February 2010. Lakshmi Srikantharajah and Indarpreet Channa 126 Investigating objective ways of measuring melanin levels in order to study vitamin d status. Natasha Shrikrishna 127 High-dose vitamin D3 during intensive phase treatment of pulmonary tuberculosis: a doubleblind randomised controlled trial. Adrian Martineau
Cancer Research UK 128 Whole colon field cancerisation in Crohn’s ilecolitis. Trevor Graham
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129 Stem Cell Niches in the Bladder? The Clonal Organization of Human Urothelium. Nadine Gaisa
Institute of Cancer 130 FGF signalling and its implication in breast cancer development. Athina-Myrto Chioni
Queen Mary, University of London 17
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Poster Presentations – Pathology Museum
Institute of Cancer 1 Shotgun identification of substrates of protein kinase Akt1 by quantitative phosphoproteomics. Luisa Beltran 2 Systematic analysis of genomic alterations in prostate cancer. Xueying Mao 3 Genome wide study of DNA methylation in AML. Marwa Saied 4 Analysis of the inflammatory profile of DCIS in relation to altered myoepithelial cell phenotype and disease progression. Michael Allen 5 Androgen-induced TMPRSS2:ERG fusion in nonmalignant prostate epithelial cells. Nuria Coll Bastus 6 Bone marrow failure in acute myeloid leukaemia is induced by a block in differentiation of normal hematopoietic stem cells. Farideh Miraki-Moud 7 Using a mouse model of Down’s Syndrome to identify novel anti-angiogenic molecules. Marianne Baker 8 An in vitro system to study the interaction between macrophages and regulatory T cells. Juliana Candido 18 Queen Mary, University of London
9 SR-A promotes colitis induced colon carcinoma. Maud Bossard 10 Towards targeting aVb6 in pancreatic cancer. Sabari Vallath 11 Src inhibition in Renal Cell Carcinoma. Kevin Sharpe 12 A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells. Katrina Sweeney 13 Widespread epigenetic inactivation of argininosuccinate synthetase renders lymphomas sensitive to pegylated arginine deiminase. Barbara Delage 14 Genetic profile of invasive breast cancer vasculature. Dylan Jones 15 The role of HAX1 in regulating avβ6-dependent cancer growth and invasion in vitro and in vivo. Chia-Yu Chen 16 High-resolution genome-wide SNP analysis suggests a monoclonal origin of multiple prostate cancer foci. Lara Boyd
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17 S100PBP is ubiquitously expressed and modulates the function of S100 calcium-binding proteins in pancreatic cancer. Kate Lines 18 The Pancreatic Expression database. Rosalind Cutts and Emanuela Gadaleta 19 Investigation of the role of ZDHHC14 in human tumour development. Dr Marc Yeste Velasco 20 Misbalance of Focal Adhesion Kinase phosphorylation enhances pathological angiogenesis. Tanguy Lechertier 21 The chemokine receptor CXCR4 and malignant transformation of the ovarian surface epithelium. Kyra Archibald 22 In-depth characterization of the micro-RNA transcriptome in Acute Myeloid Leukaemia with Solexa High-Throughput Clonal Sequencing. Silvana Debernardi 23 Accumulation of 2hydroxyglutarate (2HG) in Normal Karyotype AML patients with IDH1 mutation. Essam Ghazaly
25 Clonal selection of multiple TET2 mutations in the transormation of chronic myelomonocytic leukemia to acute myeloid leukemia and its subsequent relapse. Robert Petty 26 An autocrine cytokine network in ovarian cancer that influences patient survival. Hagen Kulbe 27 AML1/ETO and the product of its target gene POU4F1 synergise to activate B- lineage gene expression in t(8;21) AML. Jenny Dunne 28 The Role of the Chemokine CXCL12 in Extracellular Matrix Remodelling in Ovarian Carcinoma. Gemma Everitt 29 Epigenetic regulation of miRNAs in Acute Myeloid Leukaemia. Floriana Manodoro 30 Oncolytic vaccinia virus expressing decorin as a novel anti-cancer agent. Lynsey Whilding 31 c-Met endosomal signalling and breast cancer cell migration. Rachel Barrow
24 The effects of chemotherapy in combination with anti-IL-6 therapy on ovarian cancer cells. Vessela Vassileva Queen Mary, University of London 19
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Poster Presentations – Pathology Museum (cont)
32 HER2 regulates αvβ6-dependent invasion of breast cancer cells. Dr Kate Moore
40 FGFR2b prevents premature skin ageing and tumourigenesis in mice. Maria Monterrubio-Acebes
33 DCIS-modified myoepithelial cells promote angiogenesis: co-operation of avb6 integrin and Fibronectin. Dr Sally Dreger
41 Macrophage scavenger receptor A promotes tumor progression through increased B cell recruitment. Eleni Maniati
34 Targeting CCR4 in epithelial tumours. Dr Moddasar Khan
42 The role of c-Met in breast cancer drug resistance. James Hulit
35 Phosphorylation patterns that correlate with chromosomal rearrangements in AML primary cells. Pedro Casado-Izquierdo
43 C-Met trafficking stimulates Rac1 in breast cancer cells. Ludovic Menard
36 Is C-Met expression associated with prognostic parameters in invasive breast cancer? Colan Ho-Yen
Institute of Dentistry 44 Novel role of desmoglein 3 in the regulation of Ecadherin adhesion through Src signalling. Mandy Tsang
37 Changes in the microenvironment of DCIS: the relationship between altered myoepithelial cell phenotype and inflammatory infiltrate. Khairiya Ahmed
45 Two independent mechanisms regulate keratin K15 expression in keratinocytes: role of FOXM1. Amrita Bose
38 Identification of adenoviral E1A gene regions necessary for sensitisation to cytotoxic drugs in prostate cancer cells. Hector Maya
46 Effect of demineralisation solutions circulation rates on hydroxyapatite dissolution kinetics studied using scanning microradiography. Hanadi Lingawi
39 Investigating the role of FGF signaling in pancreatic cancer. Stacey Coleman
47 Developing a porous material to use as a bone scaffold. Jonathan Hatton
20 Queen Mary, University of London
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48 Sequential microtomographic measurements of enamel demineralisation inhibited by statherin-like peptides. Dr Paul Anderson 49 Surgical excision of an epulis, case report. Drs Gillam, Besas and Chatzopoulou 50 Determinants of nicotine dependence in UKresident Yemeni khat chewers. Saba Kassim 51 Measuring the interaction between statherin-like peptide and hydroxyapatite using liquid cell atomic force microscopy. Farah Ahmed 52 Immortalization of Oral human keratinocytes with defined genetic elements in the development of organotypic oral culture. Saira Athar 53 Effectiveness of fluoride foams in controlling dental caries in children. Dr Akash Jain 54 The oral health and microbiota of UK Behçet’s disease patients. Noha Seoudi 55 The effect of omega-3 polyunsaturated fatty acids on normal and neoplastic oral keratinocyte apoptosis. Zacharoula Nikolakopoulou
56 The candidate tumour suppressor HOP Homeobox (HOPX) is up regulated in human keratinocytes independently of DNA strand breaks and senescence. Alice de Castro 57 Immune responses to cytoskeletal proteins in Behçet’s disease patients. Mojgan Hamedi 58 IgG subclass distribution of total and antigen specific antibodies in Behçet’s disease patients. Lesley Bergmeier 59 Neutrophil Elastase and Secretory Leukocyte Protease Inhibitor: Investigating their role in the saliva of Behçet’s disease patients. Tanya Novak
William Harvey Research Institute 60 Inflammatory cytokines induce pericyte shape change in vivo: role in facilitating leukocyte transmigration? Doris Proebstl 61 Development of a latent IL-17 antagonist for effective gene therapy of rheumatoid arthritis. Gayatri Mittal
Queen Mary, University of London 21
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Poster Presentations – Pathology Museum (cont)
62 Gene expression and whole epigenome analysis in a model of foetal programming: the effect of folic acid. Gioia Altobelli and Irina Bogdarina
69 Syndecan-2 core protein directly interacts with the protein tyrosine phosphatase CD148/PTPRJ to promote integrin-mediated adhesion. James Whiteford
63 Generation of Schwann cell specific knockout mice reveals novel expression profile and functions for JAM-C. Bartomeu Colom
70 Transient exposure of macrophages to p38 MAPK inhibition conditions cell responses through MAPK activated protein kinase-2 (MK-2) regulation. Dr Nasser Malik
64 The role of hedgehog signalling and primary cilia in adrenal development and function. Kathryn Cogger
71 Identification of differential binding sites for FPR2/ALX ligands and AnxA1 receptor-mediated responses. Stefania Bena
65 Expression of ghrelin o-acyltransferase (GOAT), the ghrelin acylation enzyme, in various human tissues. Chung Thong Lim 66 WNT3A modulates chondrocyte phenotype through activation of both canonical and noncanonical pathways. Giovanna Nalesso 67 Characterization of interfollicular large B cells, a new subpopulation of B lymphocytes, in tertiary lymphoid organs in rheumatic autoimmune diseases. Elisa Corsiero 68 Rheumatoid synovial fibroblasts support aid expression and IG class-switching in B cells via a baff-dependent TLR3-stimulated pathway. Yvonne Kam
22 Queen Mary, University of London
72 Human neutrophils (PMN) migrating across the gingival crevice during acture capsaicin challenge are fully activated. Alex Speight 73 Coronary artery disease related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. Ross Laxton 74 Aspirin augments the anti-platelet effects of partial but not complete P2Y12 receptor blockade. Nicholas Kirkby 75 Different effects of angiotensin ii and angiotensin(1-7) on vascular smooth muscle cell proliferation and migration. Feng Zhang
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76 Establishing 3D cultures of immortalized chondrocytes to test anti-inflammatory and chondroprotective drugs. Karin Greco
83 Sequential gene expression profiles following cardiac surgery involving cardiopulmonary bypass. Eduardo Svoren
77 Involvement of autoimmunity in the pathogenesis of aggressive periodontitis. Dr Assi Hendler
84 Engineering oligodendrocyte progenitors whose growth and differentiation can be controlled by doxycycline. Alexander Annenkov
78 The use of a 96-well plate-based platelet aggregation methods as a replacement for traditional light transmission aggregometry in clinical settings. Melissa Chan 79 Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice: inhibition of the lymphotoxin-b pathway. Elisa Astorri 80 AP214, a new aMSH analogue, possesses antiinflammatory activities. Trinidad Montero 81 Targeted cytokine intervention to arrest atherosclerosis development in vivo. Dr Sandrine Vessillier 82 Targeting therapeutics to Arthritic joints. Chris Hughes
85 Heightened basal immune surveillance explains sex-differences in acute inflammatory responses. Dr Ramona Scotland 86 Sex specific Role for tRPV1 in pressure induced constriction of resistance arteries. Kristen Bubb 87 The role of primary cilia mediated hedgehog signalling in chondrocyte mechanobiology. Clare Davis 88 Identification of a novel mediator capable of dampening inflammation in vivo and enhancing phagocytosis through ChemR23. Jenna Cash 89 Progenitor cells in the adrenal cortex: focus on Sonic Hedgehog (Shh) and Preadipocyte Factor 1 (Pref-1). Leonardo Guasti With thanks to the Barts and The London Charitable Foundation for their continued support of William Harvey Day. Queen Mary, University of London 23
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90 Identification of interacting partners via yeast-twohybrid screening for the ataxia protein sacsin. David Parfitt
97 Development of novel recombinant biotherapeutics for treatment of Arthritis. Tahereh Kamalati
91 Generation and analysis of synthetic inflammation responsive promoters. Hodan Mohamed
98 Anti-inflammatory effects of prednisone and a cleavage-resistant form of Annexin 1 in immune complex-mediated Arthritis. Dr Kristin Kornerup
92 Dynamics of Melanocortin-4 Receptor processing at the endoplasmic reticulum. Nalini Ramnarace 93 Why does MRAP2 fail to save Familial Glucocorticoid Deficiency type 2 patients? Rebecca Gorrigan 94 Evaluation of the interaction of phosphodiesterases 2A and 4A5 with the aryl hydrocarbon receptor interacting protein in pituitary cells. Carole Lennox 95 In Silico enzyme and receptor fit screening of diglucopyranosylamines: a novel application for determining mechanism of action of novel drug candidates. Dr Michael Seed 96 Post-translational modification of type II collagen: the link between type 1 diabetes and rheumatoid arthritis. Rocky Strollo
24 Queen Mary, University of London
99 Differential mobilisation of neutrophils in females underlies sex-differences in ischaemia/reperfusion injury. Shimona Madalli 100 Autocrine/Paracrine CXCR1/CXCR2 signalling is required for the phenotypic stability of articular chondrocytes. Jo Sherwood 101 Dose-dependent effects of dopexamine on indices of shock and organ dysfunction in a rodent model of laparotomy and endotoxaemia. Dr Mansoor Bangash
Wolfson Institute of Preventive Medicine 102 Inflammation, depression and quality of life in cancer patients. Miss Jo Archer
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103 Effect of body mass index on recurrence in hormone receptor positive early breast cancer – A retrospective exploratory analysis from the ATAC trial. Ivana Sestak 104 Down syndrome: screening and prenatal diagnosis regionally in England and Wales 19892008. Elizabeth De Souza and Joan Morris 105 C-reactive protein in screening for coronary heart disease. David Wald and Jon Bestwick 106 Environmental Noise exposure, early biological risk and mental health in 9-10 year old children: a cross-sectional field study. Rosanna Crombie 107 How is coordination of nonverbal behaviour in interaction influenced by the presence of a patient with schizophrenia? Mary Lavelle 108 Investigating clustering in Edwards syndrome. James Cook 109 Novel diagnostic and prognostic characteristics of DNA methylated genes and their combinations in Prostate cancer. Natasa Vasiljevic
110 A pilot study to assess the feasibility and acceptability of Child-parent screening for Familial Hypercholesterolaemia. Angela Godoy 111 Risk screening converter – an interactive, simple assessment tool to see whether a risk factor is likely to be a useful screening test. Joan Morris 112 DNA Methylation profiling of 30 candidate genes reveals novel diagnostic biomarkers in Breast cancer. Mangesh Thorat 113 The incidence of venous thromboembolism (VTE) in East London. Peter MacCallum 114 Psychiatric patients’ views of involuntary hospital admission: a prospective study in 11 European countries. Claudia Dougall
Newham University Hospital NHS Trust 115 Preventing Venous Thromboembolism is not a tick box exercise. Emma Cottrell
Queen Mary, University of London 25
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116 A review of HaN in a district general hospital by medical students. Dr Carlo Prina
Tower Hamlets Primary Care Trust 117 Ethnicity specific cardiovascular risk factors in adolescents: A pilot cross-sectional comparison of British South Asian and White males. Steph Hemmings 118 A modelling approach to aid the understanding of high volume image guided injection (HVIGI) in recalcitrant Achilles tendinopathy. Dr Richard Twycross-Lewis
122 Meta-analysis of impact of lack of circumcision and Vitamin D deficiency on occurrence of prostate cancer. Professor R T D Oliver
The Blizard Institute of Cell and Molecular Science 123 Characterising a novel animal model of thymic carcinoma. Asad Mahmood
University College London
124 Impairment of oesophageal mucosal integrity after repetitive exposure to weakly acidic solutions: An in vitro model to study mechanisms of persistent symptoms in refractory gastro-oesophageal reflux disease. Dr Yasotha Duraisamy
119 Prevalence of sequence variants in phosphodiesterase enzyme 6C (PDE6C) in 8 patients with Late Onset Achromatopsia. James Berwin
125 The effects of EGFR inhibition on cancer stem cells in head and neck squamous cell carcinoma cell lines. Samim Ghorbanian
Institute of Cancer 120 Functional and clinical significance of loss of the tumour- suppressor MMP-8 in myoepithelial cells of DCIS. Muguet Sarper 121 A schools population based study of indoor vs. outdoor exercise and the contribution of vitamin D to fitness, health and academic performance. Lucy Battery and Professor Tim Oliver
26 Queen Mary, University of London
126 Docosahexaenoic acid is neuroprotective after spinal cord compression injury in the mouse. Siew-Na Lim
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Map
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London Road A121
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1 Great Hall 2 Robin Brook Centre 3 St Bartholomew the Great 4 Butchers’ Hall 5 Barbican Tube Station
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