January/February 2018
ORIGINAL CONTRIBUTION
The present study has some limitations, such as a lack of serum cortisol measurements. It is recommended that more extensive study groups of OLP and control cases should be evaluated, with the same number of female and male participants within each group. CONCLUSIONS
13 Girardi C, Luz C, Cherubini K, et al. Salivary cortisol and dehydroepiandrosterone (DHEA) levels, psychological factors in patients with oral lichen planus. Arch Oral Biol. 2011;56:864–868. 14 Ghalyani P, Tavangar A. Evaluation of anxiety and salivary cortisol level in patients with oral lichen planus. J Islam Dent Assoc Iran. 2010;22:23–29.
Although the salivary cortisol level was relatively higher in patients with OLP, a significant association between salivary cortisol level and OLP was not observed. The flow rate of saliva was significantly lower in OLP. Further studies of structural changes of salivary gland in OLP are recommended.
15 Shah B, Ashok L, Sujatha G. Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus. Indian J Dent Res. 2009;20:288.
References 1 Lehman JS, Tollefson MM, Gibson LE. Lichen planus. Int J Dermatol. 2009;48:682–694. 2 Chainani-Wu N, Silverman S, Lozada-Nur F, Mayer P, Watson JJ. Oral lichen planus: Patient profile, disease progression and treatment responses. J Am Dent Assoc. 2001;132:901–909. 3 Sklavounou-Andrikopoulou A, Chrysomali E, Iakovou M, Garinis G, Karameris A. Elevated serum levels of the apoptosis related molecules TNF-α, Fas/Apo-1 and Bcl-2 in oral lichen planus. J Oral Pathol Med. 2004;33:386–390. 4 DeRossi SS, Ciarrocca KN. Lichen planus, lichenoid drug reactions, and lichenoid mucositis. Dent Clin North Am. 2005;49:77–89. 5 Ismail SB, Kumar SK, Zain RB. Oral lichen planus and lichenoid reactions: Etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci. 2007;49:89–106. 6 Seoane J, Romero MA, Varela-Centelles P, Diz-Dios P, Garcia-Pola MJ. Oral lichen planus: A clinical and morphometric study of oral lesions in relation to clinical presentation. Braz. Dent J. 2004;15:9–12. 7 Colquhoun AN, Ferguson MM. An association between oral lichen planus and a persistently dry mouth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:60– 68. 8 Kho H-S, Chang J-Y, Kim Y-Y, Kim Y. MUC1 and toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus. Arch Oral Biol. 2013;58:837–842. 9 Artico G, Freitas R, Santos Filho A, et al. Prevalence of Candida spp., xerostomia, and hyposalivation in oral lichen planus—A controlled study. Oral Dis. 2014;20:e36–e41. 10 Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports Med. 2005;35:339–361. 11 Perogamvros I, Keevil B, Ray DW, Trainer PJ. Salivary cortisone is a potential biomarker for serum free cortisol. J Clin Endocrinol Metab. 2010;95:4951–4958.
SKINmed. 2018;16:19–22
12 Aardal E, Holm A-C. Cortisol in saliva-reference ranges and relation to cortisol in serum. Clin Chem Lab Med. 1995;33:927–932.
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16 Koray M, Dülger O, Ak G, Horasanli S, Tanyeri H, Badur S. The evaluation of anxiety and salivary cortisol levels in patients with oral lichen planus. Oral Dis. 2003;9:298– 301. 17 Carvalho PM, Castelo PM, Carpenter GH, Gavião MBD. Masticatory function, taste, and salivary flow in young healthy adults. J Oral Sci. 2016;58:391–399. 18 Lundstrom I, Goran K, Anneroth B, Bergstedt HF. Salivary gland function and changes in patients with oral lichen planus. Eur J Oral Sci. 1982;90:443–458. 19 Brand HS, Veerman E. Saliva and wound healing. Chin J Dent Res. 2013;16:7–12. 20 Kumagai K, Horikawa T, Gotoh A, et al. Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:748–754. 21 Ivanovski K, Nakova M, Warburton G, et al. Psychological profile in oral lichen planus. J Clin Periodontol. 2005;32:1034–1040. 22 Payeras MR, Cherubini K, Figueiredo MA, Salum FG. Oral lichen planus: Focus on etiopathogenesis. Arch Oral Biol. 2013;58:1057–1069. 23 Turpeinen U, Hämäläinen E. Determination of cortisol in serum, saliva and urine. Best Pract Res Clin Endocrinol Metab. 2013;27:795–801. 24 Kaur B, Sunil M, Trivedi A, et al. Salivary cortisol as a diagnostic marker in oral lichen planus. J Int Oral Health. 2015;7:43. 25 Rödström PO, Jontell M, Hakeberg M, Berggren U, Lindstedt G. Erosive oral lichen planus and salivary cortisol. J Oral Pathol Med. 2001;30:257–263. 26 Neidhart M. Elevated serum prolactin or elevated prolactin/cortisol ratio are associated with autoimmune processes in systemic lupus erythematosus and other connective tissue diseases. J Rheumatol. 1996;23:476– 481. 27 Chang JYF, Chiang CP, Hsiao CK, Sun A. Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus. J Oral Pathol Med. 2009;38:48–54.
Salivary Cortisol and Salivary Flow Rate