This handbook introduces the main challenges, opportunities and policy recommendations for Design enabled Innovation in cities across Europe. It has been developed based on the main outputs of the DESIGNSCAPES project, an H2020 CSA (Coordination and Support Action) funded by the European Commission under the Call entitled “User-driven innovation: value creation through Design Enabled Innovation”. The Action started in June 2017 and involved 12 public and private organizations (mostly academia and local government associations) from 10 EU Member States, under the leadership of ANCI Toscana, the free association of Tuscan Municipalities. The key concepts developed through the project actions are presented and exemplified by a selection of the pilot projects funded through Designscapes open calls, policy tips from Designscapes White Paper on Design enabled Innovations, together with elements of the project Toolbox.