ORAL SURGERY/ PHARMACOLOGY SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Hersh EV, Moore PA. Comment on controlling dental post-operative pain and the intraoral local delivery of drugs. Curr Med Res Opin. 2015 Oct 15:1–8. DOI:10.1185/ 03007995.2015.1109504 [doi]. Hersh EV, Pinto A, Saraghi M, Saleh N, Pulaski L, Gordon SM, Barnes D, Kaplowitz G, Bloom I, Sabti M, Moore PA, Lee S, Meharry M, He DY, Li Y. (co-authors in Div. of Restorative Dentistry) Double-masked, randomized, placebo-controlled study to evaluate the efficacy and tolerability of intranasal K305 (3% tetracaine plus 0.05% oxymetazoline) in anesthetizing maxillary teeth. J Am Dent Assoc. 2016 Jan 25. DOI: 10.1016/j.adaj.2015.12.008 [doi]. Hersh EV. New formulations of old analgesics. Clin Ther. 2015 Dec 15. DOI: 10.1016/j.clinthera.2015.11.015 [doi]. Kartha S, Zhou T, Granquist EJ, Winkelstein BA. Development of a rat model of mechanically induced tunable pain and associated temporomandibular joint responses. J Oral Maxillofac Surg. 2016; 74(1):54.e1,54.e10. DOI:10.1016/j. joms.2015.09.005 [doi]. Kufta K, Peacock ZS, Chuang SK, Inverso G, Levin LM. Components of patient satisfaction after orthognathic surgery. J Craniofac Surg. 2016 Jan; 27(1):e102–5. DOI:10.1097/ SCS.0000000000002318 [doi]. Stoopler ET, Alawi F, Stanton DC. (co-authors in Depts. of Oral Medicine and Pathology) Oral lipoma associated with multiple endocrine neoplasia (MEN) type 1. Br J Oral Maxillofac Surg. 2015 Dec; 53(10):1048. DOI:10.1016/j. bjoms.2015.09.035 [doi]. Xu Q, Le AD. Targeting cancer stem cells in oral cancer. J Calif Dent Assoc. 2016; 44(2):112–120.
Zhang Q, Yu W, Lee S, Xu Q, Naji A, Le AD. Bisphosphonate Induces Osteonecrosis of the Jaw in Diabetic Mice via NLRP3/ Caspase-1-Dependent IL-1β Mechanism. J Bone Miner Res. 2015 Dec; 30(12): 2300–12. doi: 10.1002/jbmr.2577.
RECENT NEW GRANT AWARDS Penn Multidisciplinary Consortium: Personalized Dental, Oral and Craniofacial Tissue Regeneration Sponsor: NIDCR/NIH/DHHS Principal Investigator: Dr. Anh Le, Chair and Norman Vine Endowed Professor of Oral Rehabilitation, Dept. of Oral Surgery/Pharmacology Overexpression of Notch3 by MSCs in the Pathogenesis of Jaw Bone Giant Cell Tumors Sponsor: Oral & Maxillofacial Surgery Foundation Principal Investigator: Dr. Qilin Xu, Dept. of Oral Surgery/Pharmacology
ORTHODONTICS NEWS/ACHIEVEMENTS The Department of Orthodontics will celebrate its 100th Anniversary at its annual alumni day, Friday, Oct. 28, 2016. This year’s speakers will be oral surgeons Dr. Raymond Fonseca and Dr. Tim Turvey. Attendees are eligible for CE credits. Learn more at www.dental.upenn.edu/ orthoalumniday Dr. Arnold J. Malerman, Clinical Professor of Orthodontics, was honored by HealthTAP.com as Top Orthodontist Nationally, Top Dentist Pennsylvania, and Thought Leader Philadelphia Area for the period of Winter 2015.
RECENT NEW GRANT AWARDS S. mutans-C. albicans interactions synergize the virulence of cariogenic biofilms Sponsor: NICDR/NIH/DHHS Principal Investigator: Dr. Hyun (Michel) Koo, Professor, Dept. of Orthodontics, Divs. of Pediatric Dentistry & Community Oral Health
SELECTED PUBLICATIONS A selection of recently published work by department researchers (indicated in bold). Evans M, Tanna NK, Chung C. 3D guided comprehensive approach to mucogingival problems in orthodontics. Semin Orthod. 2016 3; 22(1):52–63. DOI:http://dx.doi. org/10.1053/j.sodo.2015.10.008.
Kim D, Hwang G, Liu Y, Wang Y, Singh AP, Vorsa N, Koo H. Cranberry flavonoids modulate cariogenic properties of mixedspecies biofilm through exopolysaccharides-matrix disruption. PLoS One. 2015 Dec 29; 10(12):e0145844. DOI:10.1371/ journal.pone.0145844 [doi]. Wang Y, Hutson LD, Chen Y, Guan G. Identification and analysis of a novel bmp4 enhancer in fugu genome. Arch Oral Biol. 2015 Apr; 60(4):540–5. DOI:10.1016/j. archoralbio.2014.12.004 [doi]. Wang Y, Singh A, Hurst WJ, Glinski JA, Koo H, Vorsa N. Influence of degree-of-polymerization and linkage on the quantification of proanthocyanidins using 4-dimethylaminocinamaldehyde (DMAC) assay. J Agric Food Chem. 2016. DOI:10.1021/acs.jafc.5b05408.
INTERFERING WITH BRAIN’S “INSULATION” In collaboration with Children’s
Hospital of Philadelphia, a study from the lab of Dr. Kelly L.
PATHOLOGY
Jordan-Sciutto, may show the
SELECTED PUBLICATIONS
HIV patients often experience.
A selection of recently published work by department researchers (indicated in bold).
They found that commonly
Balashova N, Dhingra A, Boesze-Battaglia K, Lally ET. (co-author in Dept. of Biochemistry) Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA-1 expressing immune cells. Mol Oral Microbiol. 2015 Sep 11. DOI:10.1111/omi.12136 [doi].
disrupted the function of crucial
cause of the cognitive problems
Brown AC, Koufos E, Balashova N, Boesze-Battaglia K, Lally ET. (co-author in Dept. of Biochemistry) Inhibition of LtxA toxicity by blocking cholesterol binding with peptides. Mol Oral Microbiol. 2015 Sep 9. DOI:10.1111/omi.12133 [doi]. Colacurcio DJ, Zyskind JW, JordanSciutto KL, Espinoza CA. Caspase-dependent degradation of MDMx/MDM4Cell cycle regulatory protein in amyloid beta-induced neuronal damage. Neurosci Lett. 2015 Oct 15. DOI: 10.1016/j.neulet. 2015.10.031 [doi].
used antiretroviral medications brain cells that manufacture the fatty material that serves to insulate neurons, helping them transmit signals in the brain fast and efficiently. See: Jensen BK, Monnerie H, Mannell MV, Gannon PJ, Espinoza CA, Erickson MA, Bruce-Keller AJ, Gelman BB, Briand LA, Pierce RC, Jordan-Sciutto KL, Grinspan JB. Altered oligodendrocyte maturation and myelin maintenance: The role of antiretrovirals in HIV-associated neurocognitive disorders. J Neuropathol Exp Neurol. 2015 Nov; 74(11):1093–118. DOI:10.1097/ NEN.0000000000000255 [doi].
Gupta K, Kotian A, Subramanian H, Daniell H, Ali H. (co-author in Dept. of Biochemistry) Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties. Oncotarget. 2015 Sep 10. DOI:10.18632/oncotarget.5611 [doi].
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