Affiliates

Dean’s Report 2016–2017

PACESETTERS IN DISCOVERY AND CARE

Lorem ipsum dolor sit ameti consed dsdindfs elit sed o eijsijdn to orpr infcinie usdt

For more than 200 years, HMS affiliates have been key partners in the School’s education, research and patient care endeavors.

TRANSFORMING MEDICAL CARE

Judge Baker Children’s Center is working on multiple initiatives with the Commonwealth of Massachusetts and others to improve mental

HMS affiliates are known for their world-class clinical care and groundbreaking research. Pictured: the Ether

Center indicates that more effective treatments may be possible using connective-tissue cells derived from a patient’s own skin.

The Quality Care Initiative at Judge slavoer fwodoswefkemfsd kmangow lufdnd health care for children. Massachusetts Eye and Today, 15 hospital affiliates and research Dome in the surgical Baker Children’s Center helps children sIn addition to the more than 151 faculty based on the HMS campus, there are nearly 12,000 faculty at the School’s 15 affiliated hosEar | Schepens Eye Research Institute researchers computationally reconstructed the ancestral state of a viral capsid that is highly effective institutions house more than 11,000 HMS faculty whose research ranges from basic research into how cells work to clinical

amphitheater at Massachusetts General Hospital, where the first public

This year, in the global effort to combat

and families by translating evidencebased strategies into sustainable practice changes in real-world settings. Researchpitals and research institutions who provide as a synthetic vector to deliver gene therapies studies designed to transform medical care surgery using ers from Massachusetts Eye and Ear were patient care and clinical training while mentoring aspiring physicians and scientists in to the liver, muscles and the retina.

A team at Massachusetts General Hospital worldwide.

anesthetic was

performed in 1846. among leaders of an international effort to identify three genetic associations that research programs that transform medical.the Zika virus, a research team led by created a bioartificial replacement forelimb influence susceptibility to primary openThis year alone, researchers at HMS affiliBeth Israel Deaconess Medical Center has suitable for transplantation in humans. angle glaucoma, the most common form ates attained a remarkable range of achievedemonstrated that two candidate vaccines McLean Hospital investigators uncovered a of adult-onset glaucoma. ment. In cancer research, investigators at provide complete protection from the viBeth potential treatment for Parkinson’s disease Massachusetts General Hospital invesIsrael Deaconess Medical Center discovered rus in animal models, which suggests that that involves existing antimalarial drugs. tigators found that amyloid-beta protein, that a pseudogene, an RNA subclass that has a vaccine for humans may be feasible. By Mount Auburn Hospital opened a mulwhich is deposited in the form of plaques lost the ability to produce proteins, has a role in studying the genetic mutations that cause tidisciplinary program to track patients with in the brains of Alzheimer’s patients, is causing cancer. On the bioengineering front, deafness, scientists at Boston Children’s lung nodules, aiming to identify and treat a normal part of the innate immune sysinvestigators at Boston Children’s HospitalHospital have taken key steps toward decancerous lesions earlier. Researchers at tem, suggesting limitations to therapies developed a protein-based scaffolding that can veloping gene therapies to restore hearing. Spaulding Rehabilitation Hospital found that designed to eliminate amyloid plaques help the anterior cruciate ligament (ACL) repair Investigators from Brigham and a medicine to treat attention deficit hyperfrom patients’ brains. In a first-of-its-kind ipsum lore e pl;uribus.Women’s Hospital have found that people activity disorder may also help patients with study, findings by McLean Hospital reIn neurologic studies, researchers at with multiple sclerosis have different patpost-traumatic stress disorder. Studies at the searchers have linked abnormalities in cirBrigham and Women’s Hospital discovered terns of gut microorganisms from their VA Boston Healthcare System showed signs cadian rhythms to specific neurochemical a gene variant that may help patients with healthy counterparts, a finding that may of accelerated aging in the brains of U.S. changes in the brains of people with bipomultiple sclerosis better respond to a certain lead to new therapies for this disease. veterans injured by bomb blasts.lar disorder that coincide with increased medication. As a result of its efforts to imPsychologists at Cambridge Health AlliThe scope and breadth of the impressive severity of symptoms in the morning. prove health care systems, Cambridge Health ance have shaped a community safety net accomplishments that HMS partners have With the Zika virus spreading Alliance ranked among the top performers in that identifies and helps at-risk youth, an realized in the past year are truly extraordiworldwide, physicians at Mount Auburn a national pilot program aimed at reducing initiative that they say has reduced juvenary. n Hospital provided guidelines on how hospital readmission rates.nile arrests in Cambridge by more than 50 to diagnose Zika infection, including Early results of a clinical immunotherapy percent over eight years. blood tests to differentiate it from other trial at Dana-Farber Cancer Institute revealed Investigators at Dana-Farber Cancer possible diseases or co-infections, such that a cancer vaccine combined with an Institute have shown that a simple blood as dengue and chikungunya. Spaulding anti-angiogenic drug improved survival in test can accurately detect key genetic mutaRehabilitation Network researchers are certain patients with relapsed glioblastoma tions in non-small cell lung cancer, avoidconducting studies that will more accutumors. Harvard Pilgrim Health Care Instituteing the challenges of traditional invasive rately determine when concussion symphas been chosen by the U.S. Food and Drug Administration to lead the Sentinel System, a program that uses health care data to monitor biopsies. Harvard Pilgrim Health Care Institute researchers have shown that patients who experience a nonfatal overdose FOR MORE ON AFFILIATES hms.harvard.edu/hms-affiliates-research toms resolve and when athletes may safely return to sports. The VA Boston Healthcare System has implemented the the safety of FDA-regulated drugs and other of opioids often continue to receive opioid Precision Oncology Program, a clinical medical products. prescriptions—a situation that potentially care program with a research component Investigators in the Institute for Aging could be avoided by making providers intended to bring precision medicine and Research at Hebrew SeniorLife found that more aware of prior overdose events. cutting-edge cancer diagnostics and treatimperceptible vibrations applied to the soles of A study of healthy elders led by ment to veterans. n feet improved balance and gait in elderly study Hebrew SeniorLife Institute for Aging participants. At Joslin Diabetes Center, studies Research has shown that the ability to focusing on bacteria in the digestive system’s dual-task, such as walking while performmicrobiome showed that the host’s genes ing a separate cognitive task, was iminteract with microbial genes to boost insulin proved in elders by stimulating the resistance and other metabolic disorders.prefrontal cortex of the brain with a painless transcranial electrical current. In a novel approach to aid wound healing in diabetes, research at Joslin Diabetes FOR MORE ON AFFILIATES hms.harvard.edu/hms-affiliates-research