Pathological background

Eijlers AJ, et al. Brain 2018;141:2605-2618

Patients with cognitive Impairment (CI) showed a reduction in structural connettivity suggesting the presence of a network collapse or its inability to compensate for such impairment.

It is thought that CI in MS may be the result of a “disconnection syndrome “. MS pathology mainly interrupts structural pathaways connecying remote brain regions playing an important role for global cognition

Red Color shows the most represenative resting state networks:

Zhang J. Et al. Structural and Functional connectivity substrate of cognitive impairment in Multiple Sclerosis. Front Neurol Review July 2021

A) Visual Network / B) Deafault mode network / C) Cerebellum network

D) sensorimotor network / E) Auditory network / F) Executive control network

G) right frontotemporal network / H) left frontotemporal network