Isolated cognitive relapses

An Isolated Cognitive Relapse (ICR) leads to poorer long-term cognitive test scores compared with no ICR1

Baseline Relapse 6 months…

Change from baseline in the difference between relapsing patients and stable patients in raw SDMT score.

In each study, the relapsing group recovers after the relapse time point, to varying degrees, seldom returning to a difference score of 0.

ICRI , isolated cognitive relapse; MSNQ, Multiple Sclerosis Neuropsychological Questionnaire; SDMT, Symbol Digit Modalities Test

1. Pardini M, et al. J Neurol Neurosurg Psychiatry 2014;85:1035-1037;

2. Benedict RHb, et al. Mult Scler 2021; 27:71-78

Cognition in MS: a marker of silent progression