Quarterly Update Spring 2019 by OSUVetMed

BE THE SPRING 2019

Advancing partnerships to excel

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Culture and the Sustainability of Our People

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Innovative and Impactful Research

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Be the Model Comprehensive College of Veterinary Medicine in the World

Outreach and Community Engagement

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Advancing Education and Student Success

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Operational Excellence

Rooted in the foundational principles of health and wellbeing, diversity and inclusion, advancing partnerships, and resource stewardship—and in alignment with The Ohio State University strategic plan, Time and Change—the College of Veterinary Medicine’s strategic plan sets a path toward being the model comprehensive college of veterinary medicine in the world. Learn how we’re making it happen. 1 Dean’s Welcome 2 Building a pipeline for future veterinary medicine students 5 Collaborative outreach pilot program to serve as national model for homebound patients and pets 8 Novel vaccine approach proves powerful against Zika virus 10 Unique partnership keeps Bob the Pony healthy as a horse 12 Creating immersive experiences for students extends college’s local and global reach 16 On our way to becoming the model

FROM THE DEAN

Innovative partnerships lead the way for college to

BE THE MODEL

Advancing partnerships is one of the foundational principles of our strategic plan. I believe collaboration and relationship building is key to achieving our ambition to Be The Model comprehensive college of veterinary medicine in the world. In this issue, we’ll highlight how we’re strengthening relationships across campus, with industry partners, and around the globe—and how those partnerships are leading to innovations in research, education and clinical care.

Learn more about our plans to Be the Model at go.osu.edu/ BeTheModelCVM

With more health sciences colleges on one campus than any other university, Ohio State is uniquely positioned to keep our communities—and our world—healthier, happier and more productive. Working together, the health sciences Colleges of Nursing; Dentistry; Pharmacy; Medicine; Optometry; Public Health; and Veterinary Medicine, along with partners in the College of Food, Agricultural, and Environmental Sciences, embrace a One Health philosophy to optimize the health of humans, animals and our environment. A team of researchers worked together to develop and test an experimental vaccine against Zika virus that has proven powerful in mice—the results of which were published last year in the journal Nature Communications. The Colleges of Veterinary Medicine, Nursing and Social Work and teaming up in a pilot program to provide preventive care to homebound adults and their pets. The program builds on our already robust Veterinary Medicine Outreach Program. Our college is committed to nurturing students early and throughout their education to encourage the most capable and qualified to pursue veterinary medicine careers. Relationships throughout our community provide underrepresented students with the opportunity to meet and build connections with mentors. Veterinary clinical trials often lead to breakthroughs in human healthcare. In the case of Bob the Pony, human healthcare is providing the basis for his lifesaving treatment. Creating opportunities for our students to engage with the community provides hands-on experiential learning, often in environments that might be outside of a student’s prior exposure or comfort zone. The Global Engagement Program brings together research experience, course work and service learning opportunities throughout the local community, Ohio and around the globe. The personal connections we’ve formed with our alumni, peers, clients, referring veterinarians, students, faculty, staff, supporters, colleagues and friends are the partnerships that matter most. We are grateful for your continued connection with the college, and thanks to you, we will Be The Model college of veterinary medicine in the world. With Gratitude,

Rustin Moore, DVM, PhD, DACVS Dean, College of Veterinary Medicine Ruth Stanton Chair in Veterinary Medicine

EDUCATION AND STUDENT SUCCESS

BUILDING A PIPELINE for future veterinary medicine students To continue to recruit a student body that reflects the clients and owners they will serve, the College of Veterinary Medicine provides several social and educational opportunities for school-aged students aspiring to explore the world of veterinary medicine. These opportunities are advancing the college’s strategic goal of delivering extraordinary and value-driven education that prepares veterinary professionals to lead the field, advance science and achieve personal fulfillment by creating a pipeline for the next generation of veterinarians. Held both on the Ohio State campus and in the community, these opportunities offer students an inside look into veterinary school and enable them to explore veterinary medicine as a viable career option by working alongside role models and mentors.

Exploring the pathways of veterinary medicine Established in 2006, Metro Early College High School was born out of the desire of The Ohio State University and Battelle to create a STEM (science, technology, engineering and mathematics) school designed to serve students who want a personalized learning experience that prepares them for a connected

“The Metro School has an extremely diverse population of students, many of whom have dreams of becoming veterinarians.” —Dr. Raphael Malbrue, assistant professor, Department of Veterinary Preventative Medicine.

Metro Early College High School “Bodies Preprofessional” Students 2018-19 28 females

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world where math, science and technology are vitally important. This program not only exposes students to the field of veterinary medicine and different pathways within it, but also provides some of the experience necessary to be

Metro School activities prepare students to be competitive applicants for veterinary colleges and other STEM professions. Dr. Raphael Malbrue (left) and Dr. Christopher Premanandan (right) use dissections and other labs to provide interactive, engaging learning experiences for students.

competitive applicants through participation in wet labs, lectures, tours and one-on-one mentoring. Raphael Malbrue, DVM, MS, assistant professor, Department of Veterinary Preventative Medicine, serves as a liaison between Metro School and the college and is passionate about empowering students. As an African-American male—one of the least represented groups in veterinary medicine, making up less than two percent of the profession—it is a passion of his to promote and educate the next generation of veterinary professionals, especially those from underrepresented minorities and groups.

“The Metro School has an extremely diverse population of students, many of whom have dreams of becoming veterinarians,” says Dr. Malbrue. “I have had several students approach me and say that seeing a person of color achieve the goal of becoming a veterinarian gives them the confidence they need to believe that they can achieve it. That shows me that we are making an impact with our partnership.” Metro School is made possible through the facilitation and network of the Educational Council. It is the platform school for the Ohio STEM Learning Network and was the first higher education, business and K-12 partnership for STEM learning in Ohio.

An immersive experience into the daily life of a DVM candidate Buckeye Vet Prep Academy is a weeklong summer residential camp for 45-50 high school students that takes place annually on the College of Veterinary Medicine campus. Attendees participate in a variety of labs and seminars, including performing a physical examination on a dog, reading x-rays, bandaging and suturing, and also taking a behind-thescenes tour of the Columbus Zoo and Aquarium. Another highlight of the camp is the opportunity to spend a half day shadowing in the college’s Veterinary Medical Center. After choosing a veterinary specialty service to shadow, students spend the day learning from technicians and veterinary students and get to experience a day in the life of a veterinary student. Raquel Ellis, a third-year student at the college, participated as a counselor in Buckeye Vet Prep Academy and found the experience energizing. “Being involved in the camp rejuvenated me. It reminded me what it was like to strive to be a veterinarian,” says Ellis. Her work with the students allowed her to rediscover her passion for the profession. “I was able to counsel them and encourage them to pursue their dreams, which sometimes as a veterinary student can be forgotten or questioned when things get tough and stress is at an all-time high. This camp is a great resource for high school students and a way for veterinary students to get back in touch with their love of veterinary medicine.”

Buckeye Vet Prep Academy provides high school students with an immersive look into the life of a veterinary student.

Buckeye Vet Camp 2018 30 females

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OUTREACH AND COMMUNITY ENGAGEMENT

COLLABORATIVE OUTREACH PILOT PROGRAM to serve as national model for homebound patients and pets Ohio State’s Colleges of Veterinary Medicine, Nursing and Social Work recently launched the POP (Pet Owner and Pet) Care pilot program, a first-of-its-kind healthcare model, to improve the health of homebound adults and their pets. The program, funded through a Hillman Foundation Emergent Innovations grant, takes an interdisciplinary approach—transitioning from a pattern of reactive sick care into proactive, holistic well care by joining the knowledge and service of students and supervising faculty from three academic colleges. The POP Care Program brings an innovative strategy to transform the lives of homebound members of the community by creating an inter-professional team consisting of a nurse practitioner, veterinarian and social worker to address the health needs of people and their pets—with the goal of improving health outcomes for both. Approximately 60 students from veterinary medicine, nursing and social work will assess the needs of 60 households. Students will be assigned individual patients and provide home care once a week for four weeks. This opportunity builds upon a decade-

Students from the Colleges of Veterinary Medicine, Nursing and Social Work are collaborating to improve the health of homebound adults and their pets.

As pet owners themselves, Deans Dr. Rustin Moore, College of Veterinary Medicine, Dr. Bernadette Mazurek Melnyk, College of Nursing, and Dr. Tom Gregoire, College of Social Work, understand the importance of the human-animal bond.

long program the College of Veterinary Medicine had with LifeCare Alliance, through which the college has provided veterinary care to the pets of vulnerable populations served through Meals on Wheels. Laurie Millward, DVM, MS, DACVP, assistant professor, Department of Veterinary Clinical Sciences, who also leads the Veterinary Medicine Outreach Program efforts for the college,

has seen the incredible impact of community outreach. “We know from research that the human-animal bond, especially for our older neighbors who live by themselves, is beneficial to both parties’ well-being. It’s true that when you improve care for a pet, you also improve outcomes for the humans who love them.” Through its existing Veterinary Medicine Outreach Program, the college has made more than

“It’s true that when you improve care for a pet, you also improve outcomes for the humans who love them.” —Laurie Millward, DVM, MS, DACVP, assistant professor, Department of Veterinary Clinical Sciences

900 home visits to help companion animals of homebound, low-income or older adults in the last nine years, with a visit growth of more than 400 percent in the past year. Holly Dabelko-Schoeny, PhD, associate professor, College of Social Work, whose research and expertise include testing innovative interventions to support the well-being of older adults, describes the impact this program can have for all involved. “We are very excited about learning how both students and patients benefit from this experience so that this approach can be scaled more broadly.” Rustin Moore, DVM, PhD, DACVS, dean of the College of Veterinary Medicine, recognizes the rich experience this collaborative pilot program provides students. “Outreach and community engagement are a core part of our strategic plan,” says Dean Moore. “This program gives students the opportunity to practice skills through compassionate community care for animals of underserved populations, while also gaining social awareness, building cultural competencies and instilling civic responsibility.”

The POP Care program embodies the One Health concept endorsed by the Centers for Disease Control and Prevention, which suggests that the health of people can be directly connected to the health of the animals and the environment around them. Roughly two million elderly Americans are homebound, and the innovative strategy behind this program has huge potential to encourage a creative shift in today’s healthcare system for this population. Bernadette Mazurek Melnyk, PhD, APRN-CNP, FAANP, FNAP, FAAN, vice president for health promotion, university chief wellness officer and dean of the College of Nursing, and also the principal investigator for this grant, is pleased with the magnitude of this collaboration. Says Dean Melnyk, “This collaborative partnership among our health sciences colleges has great potential to change the face of well care, not only for the population of people and pets in our own community, but also to serve as a national model for other communities around the country to emulate.”

INNOVATIVE AND IMPACTFUL RESEARCH

Drs. Jianrong Li (left) teamed with Drs. Prosper Boyaka, Shan-Lu Liu and Mark Peeples to develop and test an experimental vaccine against Zika virus.

NOVEL VACCINE approach proves powerful against Zika virus A team led by Ohio State researchers has developed and tested an experimental vaccine against Zika virus that has proven powerful in mice. It employs an uncommon two-pronged approach to fighting the Zika virus, which is spread by mosquitos and is most serious for pregnant women and their fetuses. The singledose vaccine, carrying the genes for two or three Zika proteins, has proven effective in triggering an immune response that prevented later infection by Zika virus, according to the

study, which appeared in the journal Nature Communications in 2018. College of Veterinary Medicine faculty member Jianrong Li, DVM, PhD, professor, Department of Veterinary Biosciences, led the study and developed the vaccine platform. “In this study, the vaccine was potent, safe and highly effective, at least in the short term. There’s a long way to go, but we think this is a promising candidate for a human vaccine,” says Dr. Li.

Currently there is no vaccine available, though there are some in clinical trials, and the only protection against Zika are preventative measures such as mosquito repellant, staying indoors and wearing long sleeves and pants. Shan-Lu Liu, MD, PhD, professor, Department of Veterinary Biosciences, a study co-author and director of Ohio State’s Viruses and Emerging Pathogens Program within the Infectious Diseases Institute, says the experimental vaccine holds particular promise because it appears to afford an adequate immune response with one dose. In hard-to-reach, resource-poor areas, that becomes especially valuable, he points out. When this study began, the team wondered if a novel approach to vaccination—one in which they targeted a protective immune response by expressing two or three Zika proteins—might prove effective against the virus. As a vehicle for the Zika proteins, they looked to vesicular stomatitis virus, or VSV, which is a foot-andmouth disease in cattle. The weakened form of the virus is harmless in humans and mice. VSV has been used in other vaccines, including an Ebola vaccine which has been used successfully in preventing outbreaks in humans in Africa. “It’s a good platform for human vaccines, because people don’t have any antibodies against it and that allows VSV to successfully transport the vaccine without being stopped by the immune system,” says study co-author Mark Peeples, PhD, professor, The Ohio State

University and researcher, Nationwide Children’s Hospital in Columbus. In general, vaccines work by delivering harmless amounts of the target virus proteins to the bloodstream, allowing the body to build up immune responses that will provide protection in the event of subsequent exposure to the virus. Dr. Li’s work has been focused on weakening VSV so that it doesn’t cause problems, and then inserting genes from other viruses to make powerful vaccines, says Dr. Peeples, who first encouraged Dr. Li to consider applying his vaccine platform to the Zika virus. “The addition of NS1 protein is an innovative approach for a vaccine. It’s a protein that is made after the Zika virus infects a cell and is what this bug uses to replicate itself once it’s inside the host,” says Prosper Boyaka, PhD, a study co-author and professor, Department of Veterinary Biosciences. “We also looked at the response to a vaccine with just the unique NS1 gene inserted into VSV, and for the first time established that it offered partial protection all on its own, confirming its value in the vaccine.” The early success with this vaccine has encouraged this team to use the same approach to fight other related viruses, including Dengue fever, say researchers. This innovative and impactful research embodies the College of Veterinary Medicine’s goal to be a top researchfunded college and a global leader in animal and human health.

REFERRAL VETERINARY MEDICAL CENTER OF CHOICE

Bob the Pony and Dr. Teresa Burns are working together with clinicians from Ohio State’s Comprehensive Cancer Center to treat his rare cancer.

UNIQUE PARTNERSHIP keeps Bob the Pony healthy as a horse With seven health sciences colleges, an academic medical center and an academic veterinary medical center on one campus, Ohio State leads in health innovation. The Health Science Colleges of Dentistry, Medicine, Nursing, Optometry, Pharmacy, Public Health and Veterinary Medicine, along with other partners across campus, closely collaborate to discover the latest advances in healthcare.

And nowhere is that collaboration more evident than in the case of Bob the Pony. “Our patient, Bob, has a condition called chronic lymphocytic leukemia,” says Teresa Burns, MS, DVM, PhD, DACVIM assistant professor, Department of Veterinary Clinical Science. “In horses, chronic lymphocytic leukemia is exceedingly rare. We’ve never seen one here at Ohio State, and in the published equine medical

literature, there have been four cases reported, total.” Luckily for Dr. Burns, the veterinary medicine team and, most importantly, Bob, Ohio State is home to some of the nation’s leading hematologists— doctors who specialize in diseases and cancers of the blood. Chronic lymphocytic leukemia, while rare in horses, is fairly common in humans and is the primary research focus of Jennifer Woyach, MD, and John C. Byrd, MD, both of Ohio State’s Comprehensive Cancer Center (OSUCCC). So, when Dr. Burns was looking for ideas on how to best treat Bob’s illness, it made perfect sense to turn to the experts. “This collaboration, like many collaborations that happen here in this sort of mixing vessel that is Ohio State, came up sort of by chance,” notes Dr. Burns. “I happened to be at a meeting, sitting next to a hematologist, and asked her what they routinely do for relapsing chronic lymphocytic leukemia in people. That afternoon, after speaking with her, I had an email address for Dr. Byrd and Dr. Woyach and we had started this collaboration. It was an accident, but these kinds of things happen all the time here, just because of the proximity of our seven health sciences colleges, and the fact that there’s a lot of crosstalk between all of us.” Drs. Woyach and Byrd were able to steer Burns in the direction of a drug, Ibrutinib, that has proven to be highly effective in humans. The medication also has a history at Ohio State, as it was tested while in clinical development on both human and canine patients at the university. Bob’s owner is a longtime client of the Veterinary Medical Center’s Galbreath Equine Center and Hummel and Trueman Hospital for Companion Animals, which are regional referral centers of

AS SEEN ON TV!

Bob and his team of caregivers were featured on Big Ten Network LiveBIG last fall, airing regularly during Buckeye football games! Check out the segment at go.osu.edu/BobthePony

choice, combining specialty medical and surgical care with outstanding imaging and diagnostic capabilities. “We’ve had a longstanding collaboration with the College of Veterinary Medicine,” says Dr. Woyach. “One of the most exciting things for us is that we have a lot of experience testing drugs in animals and then taking them into human patients. Now we had the opportunity to actually take a drug that we know works well in humans and take it back to an animal patient.” For his part, Bob is responding well to the Ibrutinib regimen. And, due to the rarity of his disease and the effectiveness of his treatment, he has become something of a VIP in the Galbreath Equine Center. He even became known as the “grandpa” of the center due to his proximity to the neonatal ICU and his affectionate behavior towards the newborn foals he saw every day. Bob is now back at home and doing well, although he is not the best at taking his oral medications.

OUTREACH AND COMMUNITY ENGAGEMENT

Students enrolled in “Elephants, Zoo and Aquatic Medicine” spend two weeks in Thailand learning how religion, culture and social setting influence the practice of veterinary medicine.

CREATING IMMERSIVE EXPERIENCES FOR STUDENTS extends college’s local and global reach Classroom learning is a necessary part of every education, but it’s often the time spent outside the classroom that has the most impact on a student. To facilitate global engagement,

offer immersive experiences and provide a coordinated resource for students and faculty, the College of Veterinary Medicine recently established the Global Engagement Program.

Dr. Josh Yoo talks with an animal behavior expert from Global Alliance for Rabies Control while scouting for stray dogs in Addis-Ababa, Ethiopia in 2016. Yoo was there as part of the Global One Health Initiative’s rabies control program.

The program brings together research experience, course work and service learning opportunities to improve the health of animals and people, while promoting positive humananimal interactions throughout our local community, Ohio and around the globe.

Research Experience: Global One Health Initiative, Ethiopia In Ethiopia, the Global One Health Initiative (GOHi) gives students hands-on experience in field research and promotes cross-cultural communication and collaborations. For example, in 2014, a veterinary student designed a method to count dogs in the city of Gondar. A group of veterinary students implemented the project and came up with an estimate of the total dog population to be used by a GOHi rabies control program.

According to Alexandra Medley, DVM MPH, who now works with the The Centers for Disease Control and Prevention (CDC), Division of Global Migration and Quarantine, Global Border Health Team, the work she did as a student in the program created a solid foundation for the work she does today as a veterinary epidemiologist. “My work in Ethiopia with GOHi gave me the chance to learn how to collaborate with multiple partners to conduct impactful and lasting global work. The chance to work on various steps of designing studies, trainings and large overseas campaigns enabled me to gain confidence as a scientist.” Ohio State’s partnerships with universities around the world allow College of Veterinary Medicine students to work in highly interdisciplinary One Health environments. Students work with faculty from multiple disciplines to develop a broader understanding

OUTREACH AND COMMUNITY ENGAGEMENT

Immersive coursework provides students with experiences outside of urban tertiary care settings.

of their research, training or project, and to build their capacity to function beyond siloed solutions.

Course Work: International Studies, Thailand The Veterinary Field Experience in Thailand, “Elephants, Zoo and Aquatic Medicine,” was started in 2005 by Nongnuch Inpanbutr, DVM, PhD, professor, Department of Veterinary Biosciences. About 24 students per year participate in a two-week program that immerses them in coursework involving elephants, aquatic animals, wildlife and acupuncture. During their time in Thailand, students are exposed to how

the religion, culture and social setting influence the practice of veterinary medicine. Past participant Jennifer Garrett, DVM, highlighted how the experience provided growth in confidence and independence, saying, “Traveling internationally and visiting a country where English is not the primary language challenged me to be responsible for myself and be aware of my surroundings. The veterinary work provided me with much needed hands-on experiences that helped boost my confidence for my final year of veterinary school.” Immersive coursework allows students to experience a different way of practicing veterinary medicine outside of urban tertiary

care, broadening their scope of knowledge and changing the way they approach treatment options.

Service Learning: Faithful Forgotten Best Friends + LifeCare Alliance International travel isn’t required for immersive experiences that can broaden a student’s horizon. There are several local programs in the greater Columbus community that provide an opportunity to gain new perspectives on providing care for underserved and vulnerable populations of people and their pets. The college has partnered with nonprofit organizations LifeCare Alliance, Faithful Forgotten Best Friends (FFBF) and five other community organizations to provide wellness and basic veterinary care for the pets of elderly, homebound, homeless, low-income and other vulnerable residents in Franklin County. Working with these community partners, the Veterinary Medicine Outreach Program provides a unique service-learning opportunity for veterinary students by enabling them to provide veterinary care to underserved animals. Community practice and shelter rotations are an integral part of the fourth-year curriculum for students to gain valuable hands-on medical and surgical experience needed to become competent and confident veterinary practitioners. Alesha M. Glass, a fourth-year veterinary student who participated in the FFBF program can’t imagine practicing veterinary medicine upon graduating without having it involve a way to give back to the community. “Outreach medicine provided me a new way to think about how to

Service Learning experiences like Faithful Forgotten Best Friends sets a foundation of civic responsibility that many students continue after graduation.

provide care for animals because of the limited amount of resources and funding. Because of this outreach experience, I plan on giving back to my community as a practicing veterinarian,” she says. The College of Veterinary Medicine continues to identify and foster interdisciplinary collaboration to educate students and improve the health of animals, people and the environment through the expansion of these global engagement opportunities, as well as offering support for students who are interested in participating in the programs.

ADVANCING EDUCATION AND STUDENT SUCCESS

Ohio Stateâ&#x20AC;&#x2122;s College of Veterinary Medicine remains a top-ranked program by U.S. News & World Report The Ohio State University College of Veterinary Medicine ranked number four in the nation, according to the latest U.S. News & World Report Best Graduate and Professional School rankings. The college has ranked among the top five for more than a decade. The College of Veterinary Medicine also recently received international recognition, ranking in the top 10 veterinary colleges in the world by Quacquarelli Symonds (QS), a British firm whose rankings are based on reputational surveys and research

citations, including overall rankings and rankings by subject matter. The college has steadily increased in these rankings since first appearing in the top 25 in 2016, and this year was ranked number three among U.S. colleges of veterinary medicine and number eight among all veterinary colleges in the world. Ohio State is consistently recognized as a top veterinary education and research program, supporting our strategic ambition to Be The Model comprehensive college of veterinary medicine in the world.

INNOVATIVE AND IMPACTFUL RESEARCH

CULTURE AND SUSTAINABILITY OF OUR PEOPLE

Researcher Patrick Green, PhD, named associate director for basic sciences at The Ohio State University Comprehensive Cancer Center (OSUCCC) Patrick Green, PhD, associate dean for research and graduate studies, Robert H. Rainier Chair in Industrial Veterinary Medicine, professor, Department of Veterinary Biosciences, has been named associate director for basic sciences at The Ohio State University Comprehensive Cancer Center (OSUCCC). In this role, Green will facilitate basic science research throughout the comprehensive cancer Dr. Patrick Green center and work closely with other associate directors to stimulate translational research efforts. Green has extensive experience as a scientist, educator and administrator. He is a longtime member of the OSUCCC, having served as the Viral Oncogenesis Program leader for ten years and now as an active member of the Leukemia Research Program. He also is the director of Ohio State’s Center for Retrovirus Research, which is based in the College of Veterinary Medicine. His research focuses on understanding the molecular basis of T-lymphocyte transformation, as well as the induction of leukemia/lymphoma and neurological diseases by the human T-cell leukemia viruses (HTLVs). He investigates viral and cellular regulators of HTLV gene expression/replication, cellular transformation and virus survival or persistence in infected hosts.

Dr. Teresa Burns

Dr. Jerry Masty

College of Veterinary Medicine faculty chosen to mentor new faculty Teresa Burns, MS, DVM, PhD, DACVIM, associate professor, Department of Veterinary Clinical Sciences, and Jerry Masty, MS, DVM, PhD, associate professor, Department of Veterinary Biosciences, are serving as mentors in the University Institute for Teaching and Learning’s Faculty Foundation, Impact, Transformation (FIT) program. They were chosen through a selective application process and join an elite class of outstanding Ohio State teachers mentoring multidisciplinary cohorts of new-to-Ohio State faculty during the 2018-2019 academic year. The University Institute for Teaching and Learning’s Faculty FIT program is a set of coordinated learning experiences for new and developing teachers and their mentors at Ohio State. The year-long programming focuses on active support for instructional faculty at differing levels of experience, and particularly strives to engage faculty new to Ohio State.

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