Innovate December 2015 by Oklahoma Health Center Foundation

December 2015

INNOVATE Happy Holidays from the Oklahoma Health Center A publication of the Oklahoma Health Center Foundation

Celebrating 50 Years of Health Innovations in 2015 The Oklahoma Health Center

Welcome to our green publication, Innovate. This communication tool is brought to you by the Oklahoma Health Center Foundation to promote the happenings at the Oklahoma Health Center and bring you the latest information about our member organizations. Since 2000, more than $534 million in construction costs has been invested on the campus. In 2015, the OHC employee and OUHSC student count is approximately 18,000 making it one of the largest employers in Oklahoma. The Oklahoma Health Center is the premier address for research, patient care, education, technology and community health support. Located conveniently in the heart of Oklahoma City, this remarkable 325-acre complex unites 23 medical-related organizations ranging from cutting-edge biotechnology companies to government, education, patient care and community support institutions. As the second largest concentration of employees in Oklahoma, this health care consortium touts a $3 billion capital infrastucture that is continually growing to meet the needs and demands of the people. A recent study determined the Oklahoma Health Center has a more than $3 billion annual economic impact on the community.

800 N. Research Parkway, Suite 400 Oklahoma City, OK 73104 Phone: (405) 271-2200 Website: www.oklahomahealthcenter.com Follow Us on Facebook and Twitter @okhealthcenter

INSIDE Oklahoma Climbs in Americaâ&#x20AC;&#x2122;s Health Rankings

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OMRF discoveries could lead to better treatment for lymphedema

Nerdy Holidays to You: Gift Ideas for Budding Scientists from OMRF

Oklahoma Health Center: 50 Years Documentary

Oklahoma Health Center Campus Map

OHCF Members

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Oklahoma Climbs in Americaâ&#x20AC;&#x2122;s Health Rankings

Health News Increase in Immunizations, Decrease in Smoking Rates Highlight Report Oklahoma improved in America’s Health Rankings, a report issued by United Health Foundation, to 45th overall. The state has improved since ranking 49th in the nation in 2009. The report highlights progress on immunization rates, preventable hospitalizations and a reduction in the adult smoking rate. The most dramatic achievement in the report was Oklahoma’s more than 10 percent increase in the number of children immunized, from 62.7 percent in 2014 to 73.3 percent this year. That rate is almost two percent higher than the national rate of 71.6 percent and will effectively prevent children from contracting dangerous diseases. “It’s rewarding to see the progress our immunization staff and county health departments have made in providing access to life-saving vaccines for our state’s children,” said Dr. Terry Cline, Oklahoma State Department of Health (OSDH) Commissioner. “Even more rewarding is the knowledge that increasing vaccine coverage saves lives, particularly among our youngest and most vulnerable residents.”

have 88,000 kids alive in Oklahoma today who will die prematurely from smoking. That is just not right.” Oklahoma was recognized for accomplishments in other areas important to public health. In the past five years, preventable hospitalizations have declined by 29 percent for Medicare beneficiaries. Prevalence of physical inactivity was almost five percent lower than the previous year, with 28.3 percent of state residents reporting that they were not physically active. Oklahoma was also cited for strengths in low prevalence of excessive drinking and small disparity in health status by education level. While rates of obesity, diabetes and drug deaths rose in the state, those categories followed a similar national trend. The report also cites challenges in the state due to limited availability of primary care physicians and the continuing high rate of cardiovascular deaths. For the complete rankings, go to http://www.americashealthrankings.org/OK

America’s Health Rankings 2015 report also highlights Oklahoma’s lowest ever smoking rate at 21.1 percent. While still three percent above the national smoking rate, Oklahoma has continued to make dramatic improvements in the number of people who smoke. “The success we have seen in smoking rates is due to the commitment of organizations like TSET, health policy leaders such as Governor Mary Fallin and scores of community partners who have rallied to combat this health threat.” Dr. Cline said. “While we celebrate this progress together there is still work to be done. We 5

OMRF discoveries could lead to better treatment for lymphedema

The human lymphatic system is a network of vessels and lymph nodes that spans the entire body. Lymphatic vessels absorb tissue fluids and return them to the bloodstream. Defects in lymphatic vessels can cause lymphedema, a disease characterized by dramatic and painful swelling in the limbs that can lead to infection. While there is no cure for lymphedema, Oklahoma Medical Research Foundation scientists Xin Geng Ph.D., and Sathish Srinivasan, Ph.D., have identified the molecules that control the formation of the key valves that direct the flow of lymph into the blood circulation. The findings, which were published in the journal Developmental Biology, may help researchers develop new ways to manage lymphedema. “Using high-power imaging techniques, we were able to determine the three-dimensional structure of the lymphovenous valves in mouse embryos,” said Srinivasan. “We found that these valves are defective in four different models of lymphedema.”

tervention in lymphedema. Currently, the only options are conservative treatments like massage and compression bandages. “If we can repair the damage in these structures, it is quite possible that we can, at least to a certain extent, repair the damage to the lymphatic vascular function,” said Srinivasan. “This is an exciting step with many possibilities.” Other OMRF scientists who participated in the work are Boksik Cha, Ph.D., Riaj Mahamud, Robert SilasiMansat, Ph.D., Lijun Xia, M.D., Ph.D., and Florea Lupu, Ph.D. This research was supported by institutional funds of OMRF, Oklahoma Center for Adult Stem Cell Research grant No. OCASCR 4340, American Heart Association grant No. 15BGIA25710032 and National Institute of General Medical Sciences grant No. P20 GM103441.

There are only four lymphovenous valves in the entire human body—two on either side of the neck. Srinivsan said the valve system functions something like the intersection of two major highways. “During peak rush time, the traffic flow is dictated by what’s happening at the junction where the highways meet,” he said. “If something occurs to block traffic at that busy intersection, it causes a traffic jam and lines of traffic build up. Similarly, malfunctions in the lymphovenous valves act like a bottleneck and can bring everything to a halt. Even if the system is functioning well everywhere else, if these valves are defective, the lymph can’t go anywhere.” By mapping these valves in three dimensions, it allowed medical researchers the ability to look at them in detail for the first time. Srinivasan said he and his colleagues found an immediate correlation between malformed valves and disease. This wealth of new information is crucial, said Srinivasan, because it creates an opportunity for clinical in-

Nerdy Holidays to You: Gift Ideas for Budding Scientists

Oklahoma Medical Research Foundation scientists Chris Sansam, Ph.D., and Courtney Sansam, Ph.D., and their son Mitchell, 6, piece together an original invention using a Snap Circuits Electronic Discovery kit.

OMRF (omrf.org) is an independent, nonprofit biomedical research institute dedicated to understanding and developing more effective treatments for human diseases. Its scientists focus on such critical research areas as cancer, diseases of aging, lupus and cardiovascular disease. 8

Educational Gifts Maybe you have an aspiring Einstein on your holiday gift list. Or perhaps you’re just looking to add a little something different to the collection of Star Wars toys, video games and assorted digital devices under the tree. Either way, Oklahoma Medical Research Foundation scientists have put together a gift list for the scientifically inclined child. “Kids are naturally curious,” said OMRF researcher Tim Griffin, Ph.D. “The best toys support creativity and thinking.”

It’s electric! Snap Circuits Electronic Discovery kits (Ages 8 and up; $34.99 and up) OMRF’s Courtney Sansam, Ph.D., recommends these kits for engineers-in-training. Each set contains easy and fun electronic building blocks that allow children to channel their inner inventors. “Our son loved being able to connect pieces together to see what would happen,” said Sansam. “He made a doorbell and a light switch, and we’ve continued to add more kits to his collection.”

A whole new (digital) world Osmo Gaming System for iPad (Ages 5 to 13; $79.99)

You go, girl GoldieBlox building kits (Ages 3 and up; assorted kits $10.99 and up) Created with the mission of encouraging girls to develop an interest in engineering, these story-themed construction sets combine action figures with parts and instructions for building everything from a dunk tank to a rocket ride. Husband-and-wife scientists Tim Griffin, Ph.D., and Courtney Griffin, Ph.D. recommend GoldieBlox to enhance any girl’s interest in learning through experience. “Science is all about discovery and possessing the tools to learn something new,” said Tim Griffin.

Cracking the genetic code Thames & Kosmos Biology Genetics and DNA kit (Ages 10 and up; $36.95) This gift provides kids with a do-it-themselves introduction to genetics. With it, they can isolate DNA from fruits and vegetables, learn how traits are passed from parents to children, and even discover how to analyze DNA to solve crimes. “Hands-on science activities foster excitement about experimentation and discovery of how the world works,” said OMRF researcher Susan Kovats, Ph.D.

For computer-savvy youngsters, Sansam’s husband, OMRF scientist Chris Sansam, Ph.D., suggests this educational game system for iPad. Using a mix of digital technology and real-life objects like puzzle pieces or your child’s favorite toys, Osmo allows kids to create virtual worlds and games that they can control. Time magazine chose this gaming system as one of its best inventions of 2014.

Oklahoma Health Center Campus *Member Organizations Oklahoma Health Center Foundation

1. American Red Cross of Central Oklahoma* 2. Dean McGee Eye Institute* 3. Department of Veterans Affairs Medical Center 4. Easter Seals Oklahoma* 5. Office of the Chief Medical Examiner 6. Oklahoma Allergy and Asthma Clinic* 7. Oklahoma Blood Institute* 8. Oklahoma City Clinic*/Global Health Inc. 9. Oklahoma Medical Research Foundation (OMRF)* 9a. OMRF Research Tower 9b. OMRF Bell Building 9c. OMRF Acree-Woodworth Building 9d. OMRF Massman Building 10. Oklahoma School of Science and Mathematics* 11. Oklahoma Department of Health* 12. Oklahoma State Department of Mental Health and Substance Abuse Services* 13. Department of Human Services 14. OU Medical Center* A. Presbyterian Office Building B. OU Medical Center C. Radiation Therapy Center D. The Children’s Hospital E. Oklahoma Transplant Center F. OU Medical Surgery Center 15. OU University Research Park (formerly Presbyterian Health Foundation Research Park) A. Building 800 Biolytx Biosource Charlesson Crisalis Cytovance Biologics Medencentive Oklahoma Health Center Foundation* OUHSC Research Labs Rural Enterprises Inc. Transtimulations Research B. Building 840 ARL* DNA Solutions* i2E, Inc.* Labcorp Orthocare Innovations Selexys

C. Building 655 Advancia Corporation OU Medical Center* Hyalose, LLC InterGenetics, Inc. Oklahoma State Regents for Higher Education OneNet OUHSC Potts Family Foundation Presbyterian Health Foundation* Selexys SIWA Smith & Nephew D. Building 755 Altheus Dermamedics Nova Venture Services, LLC Oklahoma Center for the Advancement of Science and Technology (OCAST) URP Management Offices OUHSC Facilities Management OUHSC Risk Management OUHSC Fire Marshall OU Compliance Office Altheus Haus Sickle Cell Foundation Sylvia Bottomly OU College of Public Health Productive Tech Veterans Affairs New Spin 360 E. Building 825 Camille’s Sidewalk Café and Richey’s Grill URP Shipping/Receiving PHF Video Conference Center-Conference Rooms F. Building 885 Cytovance Biologic Manufacturing G. Building 865 Accele Biopharma Analytical Edge Labs DRIK Labs Miles Associates OUHSC – Comparative Medicine OMRF

16. University of Oklahoma Health Sciences Center* A. Allied Health Practice Center B. Basic Sciences Education Building C. Campus Police Station D. College of Allied Health E. College of Dentistry F. College of Medicine/Biomedical Sciences Building G. College of Nursing H. College of Pharmacy I. College of Public Health J. David L. Boren Student Union K. Don E. Hogg Greenhouse L. G. Rainey Williams Pavilion M. Harold Hamm Diabetes Center N. O’Donoghue Research Building O. Stephenson Cancer Center P. OU Children’s Physicians* Q. Child Study Center R. OU Physicians* Building S. Mark Allen Everett Dermatology Building* T. Family Medicine Center* U. Robert M. Bird Library & Graduate College V. Rogers Building W. Service Center Building X. Stanton L. Young Biomedical Research Center Y. Steam and Chilled Water Plant Z. University Health Club AA. University Village (owned by OUNorman) 17. University Hospitals Authority and Trust* 18. Ronald McDonald House Charities of Oklahoma City* 19. Ronald McDonald Family Room (in The Children’s Hospital) 20. Ronald McDonald House II (in Garrison Tower) 21. Founders Plaza at Stiles Park featuring The Beacon of Hope 22. OK Kids Corral 23. Embassy Suites Children’s Hospital Foundation* (not currently on campus)

Oklahoma Health Center Celebrates Fiftieth Year of Founding in Documentary A documentary on the history of the Oklahoma Health Center was produced by the Oklahoma Health Center Foundation and funded by the Treasures For Tomorrow program. The documentary is being shown on OETA, Cox On Demand and also is available for viewing through the Oklahoma Health Center Foundation’s You Tube page - https:// www.youtube.com/watch?v=7A9xnJieq_s The documentary starts in 1965 when the area now known as the Oklahoma Health Center was just a few buildings – a medical school and two hospitals. Visionaries including Harvey P. Everest, E.K. Gaylord, Dean A. McGee, Dr. Don O’Donohue and Stanton L. Young organized a trip to Houston to see the Texas Medical Center to see if they could recreate something similar in Oklahoma. The answer was a resounding yes and now the Oklahoma Health Center touts a $3 billion impact on Oklahoma’s economy. More than 18,000 employees and students travel to the Oklahoma Health Center each day. The documentary explores the challenges faced and how those obstacles were overcome leading to what the Oklahoma Health Center is today and a glimpse into its ever-changing future. Those interviewed include University of Oklahoma President David Boren, Vice President and Provost OU Health Sciences Center Dr. Jason Sanders, OU College of Medicine Dean Dr. Dewayne Andrews, and Oklahoma Health Center Foundation President Terry Taylor. The Oklahoma Health Center Foundation is a consortium of 23 private, educational, governmental and nonprofit organizations, located on 325 acres just south of the Capitol complex in Oklahoma City. These organizations represent the areas of patient care, research, technology, education and community support with the common goal of improving health and creating high-tech jobs in Oklahoma and the nation. Visit www.oklahomahealthcenter.com for more information. 12

Member Organizations American Red Cross of Central Oklahoma

ARL Bio Pharma, Inc.

Children’s Hospital Foundation

Dean McGee Eye Institute

DNA Solutions, Inc.

Easter Seals Oklahoma

Emergent Technologies, Inc.

i2E, Inc.

Oklahoma Allergy & Asthma Clinic

Oklahoma Blood Institute

Oklahoma Health Center Foundation

Oklahoma Center for the Advancement of Science and Technology

Oklahoma City Clinic

Oklahoma Department of Mental Health & Substance Abuse Services

Oklahoma Medical Research Foundation

Oklahoma School of Science & Mathematics

Oklahoma State Department of Health

OU Medical Center

OU Physicians

Presbyterian Health Foundation

Ronald McDonald House Charities® of Oklahoma City

University Hospitals Authority and Trust

University of Oklahoma Health Sciences Center: College of Allied Health • College of Dentistry College of Medicine • College of Nursing College of Pharmacy • College of Public Health Graduate College

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Member Central & Western Oklahoma Mark Smith, Interim CEO 601 Northeast Sixth Street Oklahoma City, OK 73104 Phone: (405)228-9500 Website: www.redcross.org/ok/oklahoma-city Jobs: www.redcross.org/about-us/career

survivors, and to the people who generously support our work through donations.

The American Red Cross prevents and alleviates hu-

man suffering in the face of emergencies by mobilizing the power of volunteers and the generosity of donors.

The Central and Western Oklahoma Region of the American Red Cross covers a 47 county region totaling 42,000 square miles. Our regional office is based in Oklahoma City with 18 offices and service centers across the region. The humanitarian mission of the American Red Cross connects us to people and communities across the nation and around the world. The common bonds of humanity and compassion unite us together, not just in the face of emergencies and disasters, but in helping our neighbors every day. Since being founded by Clara Barton in 1881, the Red Cross has been a consistent lifeline for people when they need us the most. The depth and breadth of our services – whenever and wherever they’re called for – is unmatched by any organization in the world. The Red Cross was chartered by the United States Congress to “carry on a system of national and international relief in time of peace and apply the same in mitigating the sufferings caused by pestilence, famine, fire, floods, and other great national calamities, and to devise and carry on measures for preventing the same.” The Charter is unique to the Red Cross because it assigns duties and obligations to the nation, to disaster 14

Red Cross disaster relief focuses on meeting people’s immediate emergency needs caused by disaster. When disaster threatens or strikes, the Red Cross provides shelter, food, and health and emotional health service to address basic human needs and assist individuals and families in resuming their normal daily activities independently. We support members of the military, veterans and their families in coping, connecting and obtaining financial assistance. This is done at Tinker Air Force Base, Vance Air Force Base, Altus Air Force Base and Fort Sill. We train individuals, families and organizations with lifesaving skills and emergency and disaster preparedness information. The Red Cross has been the go-to source for more than a century for information, skills and confidence to act in an emergency, at home, in school and in the workplace. The American Red Cross is the nation’s largest blood collection organization, supplying approximately 40 percent of the blood and blood products used in our country. We are a global leader in responding to emergencies, preparing for disasters, preventing disease and promoting humanitarian values.

Member

Tom Kupiec, Ph.D., President and CEO 840 Research Parkway Suite 546 Oklahoma City, OK 73104 Phone: (405)271 1144 Website: www.arlok.com Analytical Research Laboratories (ARL) provides analytical and microbiological testing for the pharmaceutical industry. Located at the University Research Park in Oklahoma City, ARL occupies approximately 19,000 square feet of state of the art laboratory and office space and positions itself as a leader among emerging and growing biotechnology companies nationwide. ARL has been serving the clinical and pharmaceutical markets since 1998. ARL offers a comprehensive range of analytical and microbiological services applicable for pharmaceuticals and medical devices. ARL services routinely include assay for pharmaceutical ingredients, stability studies, and full compendial testing. ARL is well equipped with instrumentation, such as High Performance Liquid Chromatography (HPLC), HPLC-Tandem Mass spectrometry (HPLC/MS/MS), High resolution Time of Flight Mass Spectrometry (LC-MS) for accurate molecular weight determination and analysis of proteins/peptides with an upper mass range of 20,000 m/z, Gas Chromatography (GC), GC/MS, high resolution Fourier Transform Infrared (FTIR), Polarimeter, ELISA, Genetic Analyzer, Thermal

Cyclers, Luminometer, and Environmental Chambers. ARL has a dedicated team of scientists and e x p e r t s continually delivering research solutions for the pharmaceutical industry and governmental institutions. ARLâ&#x20AC;&#x2122;s competent personnel with regulatory expertise provide a comprehensive approach to analytical testing, as well as forensic and pharmaceutical consultations. Additional experience includes: pharmacogenomics, biomedical sciences, medical technology, immunohematology and expert witness testimony. ARL is an FDA registered analytical laboratory and DEA licensed. ARL is ISO 17025:2005 accredited as applicable to our scope of accreditation. ISO outlines general requirements for the competence of testing and calibration laboratories. An independent QA/QC department conducts internal audits of the laboratories as a part of a quality management system.

Member

Kathy McCracken, Executive Director 6501 N. Broadway Extension, Suite 190 Oklahoma City, OK 73116 Phone: (405) 271-2260 Toll Free: 888-229-KIDS Tax ID: #73-1200262 Website: www.okchf.org Children’s Hospital Foundation is the only nonprofit organization in Oklahoma whose sole focus is the advancement of pediatric research and education while supporting specialized clinical care for Oklahoma’s children. It supports pediatric specialists who treat more than 213,000 patient visits every year, including children from all 77 counties in Oklahoma. Since its inception in 1983, Children’s Hospital Foundation has raised and leveraged matching funds to create more than $100 million for pediatric research, quality specialized clinical care and education programs. Many of these endeavors include collaborative projects with the University of Oklahoma College of Medicine and Children’s Hospital at OU Medical Center in Oklahoma City. Current program and research focus areas include: • Infectious disease • Arthritis • Education • At-risk newborns • Diabetes-Obesity • Digestive health • Cancer • Genetics • Community pediatrics • Surgery & Emergency • Autism-ADHD-Down Syndrome • Lung, kidney and heart disease • Adolescent medicine • Eating disorders • Behavioral medicine • Child abuse and neglect Funding for programs is made possible through the efforts of a dedicated volunteer board and thousands of community volunteers and donors. Through endowments and direct support, Children’s Hospital Foundation is able to recruit and retain nationally and internationally recognized pediatric physician-scientists to direct research, as well as

treat patients and train medical students. All funds raised in Oklahoma stay in Oklahoma to improve the lives of kids here at home. Children’s Hospital Foundation is a proud affiliate of Children’s Miracle Network Hospitals, an international nonprofit organization dedicated to helping sick children by raising funds and awareness for 170 member hospitals throughout North America. Children’s Miracle Network Hospitals organizes and executes thousands of special events and promotions each year through its dedicated corporate sponsors and media partners and keeps 100 percent of its donations in the community where they were raised. Children’s Medical Research Institute and The Children’s Hospital at OU Medical Center are part of the network hospitals. The Foundation is currently recruiting endowed chairs and has naming opportunities available. For more information, contact Children’s Hospital Foundation toll free 888-229KIDS (5437) or (405) 271-2260.

Member

President and CEO Greg Skuta, M.D. 608 Stanton L. Young Blvd. Oklahoma City, OK 73104-5065 Phone: (405) 271-6060 Website: www.dmei.org Benchmarks of Dean McGee Eye Institute Excellence The Dean McGee Eye Institute is one of the largest and most respected eye institutes in the United States, providing more than 160,000 patient visits per year from all 77 Oklahoma counties and the surrounding region, and serving more than 7600 surgical patients annually in its state-ofthe-art ambulatory surgery center. Twenty of the Eye Institute’s ophthalmologists are listed among the Best Doctors in America. In 2012, the University of Oklahoma (OU) College of Medicine’s Department of Ophthalmology, which is housed in the Dean McGee Eye Institute, ranked 14th in the country in National Institutes of Health funding and 11th in the nation in cumulative funding from Research to Prevent Blindness. The Dean McGee Eye Institute’s residency program (in affiliation with the OU College of Medicine) attracts top medical students from throughout the nation. Resident surgical education has consistently ranked above the 90th percentile nationally. Since 2000, the first-time pass rates on the American Board of Ophthalmology’s written and oral examinations are 100% and 98% respectively with an average score on the written examination at the 80th percentile. The Eye Institute’s Director of Vision Research is a Past President of the International Society for Eye Research, Past Vice President of the Association for Research in Vision and Ophthalmology (ARVO) and a recipient of ARVO’s prestigious Proctor Medal; two members of the faculty are recent or

current directors of the American Board of Ophthalmology; three serve on the Board of Trustees of the American Academy of Ophthalmology; one serves as Vice Chair of the Residency Review Committee in Ophthalmology for the Accreditation Council for Graduate Medical Education; and one is President of the American Academy of Ophthalmology and a Past President of the American Glaucoma Society. The Dean McGee Eye Institute provides more than $1 million of care to needy Oklahomans each year.

Thomas C. Kupiec, Ph.D., CEO and President 840 Research Parkway, Ste. 551, Oklahoma City, Oklahoma 73104 Toll Free: (866) 362-9778 Phone: (405) 271-6033 Website: www.dnasolutionsusa.com DNA Solutions, Inc. is a genetic testing laboratory providing highly discerning services including: relationship and forensic testing in humans and animals. Located at the University Research Park in Oklahoma City, DNA Solutions provides unique laboratory solutions to our customers including custom genetic research studies and forensic testing. DNA Solutions is accredited to the highest standard, ISO 17025. ISO/IEC 17025:2005 sets the international laboratory standard for testing laboratories. In addition, DNA Solutions is a CLIA registered laboratory and has its New York State Department of Health Laboratory Permit. DNA Solutions is also accredited by the American Association of Blood Banks (AABB) for relationship testing. AABB accreditation is granted only to laboratories that achieve high quality performance for relationship testing which follows strict quality guidelines that cover all aspects of parentage testing from initial specimen collection to the issuance of the final results.

The company provides research and development expertise in the area of single nucleotide polymorphism (SNP) detection, DNA sequencing for forensics and human and animal genotyping, bacterial / fungal identification, biological patent infringement and ancestry testing. DNA Solutions maintains the deer registry for North American white-tailed deer and mule deer breeders as well as providing genotyping services to wildlife enforcement agencies. One significant distinguishing characteristic of DNA Solutions is the personal client services our company provides. DNA Solutions prides itself in providing high touch customer service to all of our clients. Our highly skilled and knowledgeable personnel are accessible to our clients for questions and explanations regarding results provided to our clients. DNA Solutions provides services worldwide and services are legally defendable and meet or exceed the applicable standards for genetic relationship testing. For over 14 years, the innovative scientists at DNA Solutions have been helping people discover the answers contained within the strands of DNA.

Member

Paula K. Porter, President & CEO 701 NE 13th Street Oklahoma City, OK 73104 Phone: (405)239-2525 Website: www.eastersealsok.org

More than 56 million Americans have a disability which accounts for approximately 19 percent of the population. Easter Seals Oklahoma is the leading nonprofit provider of services for individuals with disabilities and is trying to bridge the gap for the increasing number of Oklahomans needing services.

prove their ability to remain independent. The program provides various activities to stimulate minds, promote social interaction, and keep everyone moving. Our child development center includes an onsite early intervention and childhood learning program for children with disabilities as well as typical children. A new peer integration program was just developed to increase early intervention and consultation services are also available for parents and teachers that need additional support and training on developmental disabilities. Easter Seals Oklahoma also provides direct financial assistance for children needing therapy, as well as a variety of rehabilitative equipment that is necessary for a childâ&#x20AC;&#x2122;s development. Medical rehabilitation is available onsite for behavioral, occupational, and speech therapies. It is our mission at Easter Seals Oklahoma to enhance the quality of life for children and adults with disabilities so they may live with equality, dignity, and independence. Thanks to the support of the community, we are able to fulfill our mission.

For more than 88 years, we have been offering help and hope to children and adults with disabilities and to the families who love them. Through therapy, training, education and support services, Easter Seals Oklahoma creates life-changing solutions so that people with disabilities can live, learn, work, and play. Our adult day center provides special care for adults who are unable to care for themselves for extended periods of time and enables them to maintain or im-

Member

Thomas A. Harlan, Chairman, President, and Chief Executive Officer 800 Research Parkway, Suite 340 Oklahoma City, OK 73104 Phone: (405)271-3838 Website: www.emergenttechnologies.com ETI is a regionally-based venture capital and management services firm that specializes in forming, funding, commercializing, and managing companies for the purpose of converting institutional and university-based technology into high return ventures. Its unique process matches breakthrough technology with commercialization partners who can validate the market potential and expeditiously bring the technology to market. Investors can have confidence that risks will be reduced and the time to liquidity accelerated because ETI’s process avoids unproven technologies, large front-end investments, and dependency on the IPO market. ETI created its first investment fund, Emergent-OU, Ltd., in 1999 to launch three technologies emanating from the University of Oklahoma Health Sciences Center in Oklahoma City, OK. Its second fund, Emergent Technologies Oklahoma, L.P. was created in 2000 to make further investments in the first three companies and provided seed capital for the fourth and fifth companies. Pure Protein has developed a unique method to produce soluble HLA protein from human cell lines. The company is focused on the discovery of new targets to prevent and treat infectious disease and cancer. Pure Protein’s core technology platform allows the production of large quantities of immune surveillance proteins and provides unique insight to the inner workings of diseased cells. It has created two subsidiaries, Pure Transplant Solutions, L.L.C. and Pure Vaccine Solutions, L.L.C. The Pure Protein platform enables a distinct toolset for evaluating and improving vaccines as well as reducing unwanted allergic reactions from bio therapeutics. www.pureproteinllc.com Hyalose, L.L.C. has developed unique capabilities for the recombinant production of hyaluronic acid both in bulk production using fermentation and in enzymatic synthesis where a very high level of control is possible in determining the exact molecule that is synthesized. Controlled enzymatic synthesis also enables the placement of other glycosaminoglycan sugars and unnatural sugars at precisely defined positions in the sugar chain creating new novel sugar compounds. The company has licensed several genes from different species of bacteria that synthesize hyaluronic acid. www.hyalose.com

MedUnison – Formerly known as MedSynergy, MedUnison’s DocSynergy is an online, secure medical community for physicians and other healthcare providers to dramatically improve the quality of healthcare delivery, while significantly lowering the cost of treatment. The DocSynergy solution harnesses the benefits of distance medicine through unique technology to enable physicians to tap the expertise and knowledge of colleagues regardless of location. The DocSynergy solution is built for the rural physician, the urban specialty group, and physicians working with captured patients, such as those in correctional facilities. www.medunison.com Heparinex, L.L.C. is a biopharmaceutical company focusing on the novel recombinant synthesis of compounds for the growing anticoagulation market and associated arenas. The core technology platform was originally discovered and patented by a leading carbohydrate chemist/ glycobiologist at the University of Oklahoma in 2002. Heparinex’s core platforms employ (a) bacterial production techniques and (b) in vitro defined polymer syntheses to provide uniquely controlled non-animal sources of genetically customizable heparinoid compounds for drug discovery, therapeutic formulations and medical device applications. www.heparinex.com Choncept is a biotech company focused on development of new technology to produce chondroitin from fermentation of recombinant bacteria to replace the current chondroitin source of beef and other animal by-products. Chondroitin produced by the gene patented by Choncept is unsulfated which can be sulfated to produce chondroitin similar to that isolated from animal sources. The unsulfated chondroitin may also be of interest as a biomaterial. Chondroitin produced recombinantly may be significantly less expensive to produce than current methods that rely on animal by-products. Modified chondroitin, dermatan sulfate, has properties as an anti-coagulant, an important pharmaceutical market. www.choncept.com

Member

Scott Meacham, President & CEO University Research Park 840 Research Parkway, Suite 250 Oklahoma City, OK 73104 Phone: (405)235-2305 800/337-6822 TOLL FREE 800/337-6822 TOLL FREE for Oklahoma Website: www.i2e.org i2E, Inc. is a nationally recognized private not-for-profit corporation focused on growing innovative small businesses in Oklahoma and making a positive impact on the state’s economy. Our stated mission is “Investing in Entrepreneurs to build successful high growth companies in Oklahoma.” We achieve our mission by working directly with entrepreneurs, researchers and companies to help them commercialize their technologies, launch and grow new businesses and access needed capital. Our clients like the fact that our staff consists of experienced entrepreneurs and investors who have walked in their shoes. Busy entrepreneurs tell us that our model works for them because we not only provide high quality business advice, capital and entrepreneurial development, we act as a portal to other private and public resources — making it easier to access the right information, expertise and investment at the right time. The results speak for themselves: Clients enjoy job, revenue and capital growth significantly higher than the state average. The state benefits from new globally competitive businesses, high quality jobs and an enhanced quality of life.

Our History: Originally founded in 1997, i2E was created to respond to an Oklahoma Center for the Advancement of Science and Technology (OCAST) initiative. Since we opened our doors for business in 1998, i2E has assisted hundreds of entrepreneurs, companies, inventors and researchers turn their innovations into high growth business opportunities for Oklahoma.

Member

Serving Oklahoma and the southwest since 1925, the Oklahoma Allergy & Asthma Clinic is one of the oldest and largest medical practices in the United States dedicated solely to the treatment of allergy, asthma and immunology. The Oklahoma Allergy & Asthma Clinic has nine physicians on its medical staff; certified or board eligible by the American Board of Allergy & Immunology and are on the teaching faculty at the University of Oklahoma College of Medicine. The Oklahoma Allergy & Asthma Clinic is one of only a few allergy groups in the United States with a full-time Nurse Practitioner who holds a Doctorate and is a pulmonary disease management coordinator consulting with individual patients about breathing techniques and asthma education. Also on staff is a full-time, registered, licensed nurse practitioner. Almost one-fourth of The Oklahoma Allergy & Asthma Clinicâ&#x20AC;&#x2122;s patients are referred from outside Oklahoma City and travel many miles for the sophisticated, high-level allergy and asthma care and to participate in the numerous research studies. The Oklahoma Allergy & Asthma Clinic has a Burkard pollen and mold collection instrument on the roof of its main location and provides the daily counts to the media and the counts are also posted on the website and on social media. The Oklahoma Allergy & Asthma Clinic has its central clinic location on the Oklahoma Health Center campus. Three fullservice satellite clinics are located in Edmond, Norman, and Northwest Oklahoma City, adjacent to Mercy Hospital. How is an allergist different than a regular physician? An allergist is a doctor who is an expert in the diagnosis and treatment of allergic diseases and conditions. Those conditions include asthma and frequent coughing; hay fever; sinus infections; eye allergies; reactions to food, insect stings and drugs; and immune system problems that might cause

Gordon Heiselbetz, COO 750 N. E. 13th Street Oklahoma City, OK 73104-5010 Phone: (405) 235-0040 Website: www.oklahomaallergy.com Facebook oklahomaallergyandasthmaclinic Twitter @okallergyasthma frequent infections. You should see an allergist if you have any of these conditions. More than 50 million people in the United States have these allergic diseases. Although symptoms may not always be severe, allergies and asthma are serious and should be treated that way. Many people with these diseases simply donâ&#x20AC;&#x2122;t realize how much better they can feel with proper treatment. An allergist is trained to find the source of symptoms, treat it and help patients feel healthy. After earning a medical degree, the doctor must complete a three-year residencytraining program in either internal medicine or pediatrics. Then, an allergist completes two or three more years of study in the field of asthma, allergy and immunology.

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ity to recruit marrow registrants from ethnically and agediverse populations.

John Armitage, M.D., President, CEO 1001 N. Lincoln Blvd. Oklahoma City, OK 73104 Phone: (405) 278-3100 Website: www.obi.org Oklahoma Blood Institute (OBI) is the ninth largest, nonprofit blood center in America. Every drop of blood needed by patients in more than 140 medical facilities in Oklahoma is provided by donors with OBI. This includes exclusive service for every hospital in the metro-OKC area. An average of 700 donors a day is required to meet these needs. Volunteer blood donors give more than a 287,000 units of blood annually to provide a safe and adequate blood supply. Blood donors with Oklahoma Blood Institute know they are, literally, saving the lives of their friends, family and coworkers, some who may have no idea they will need blood in an urgent situation. One blood donation can save as many as three peoples’ lives. OBI is responsible for recruiting blood donors, collecting, processing and testing blood components and transporting it to hospitals across our state. Random inspections by the Food & Drug Administration (FDA) confirm the quality of our operations at every donation site. OBI’s perfect record through 36 straight inspections validates our quality exceeding regulatory requirements.

Oklahoma’s first and only umbilical cord blood bank is in the final phases of FDA accreditation at OBI. It is one of only 24 accredited centers worldwide. Expectant mothers of underserved ethnic descent families now have an opportunity to donate cord blood. There is no charge to the parents, and the donation process is simple and painless. During a blessed time in their own lives, this cord blood center enables Oklahoma families to potentially bring life-saving joy to someone else’s. OBI is a vital link in cell therapy, procuring healthy stem cells for transplants from adult marrow and umbilical cord donations. The future holds great promise as we expand research and treatments partnerships within the healthcare biosciences industry. Cell therapies and regenerative medicine applications are predicted to revolutionize care for the most life-threatening diseases. We are uniquely positioned as a ready-made ‘cell bank’ with hundreds of thousands of combinations of genetic characteristics among our blood donors. These giving people may be offered the opportunity to further make a difference in the lives of others as part of medical research. Oklahoma Blood Institute can accelerate this revolutionary research cost effectively, so that today’s vision more rapidly becomes the reality of life-enhancing, routine medical treatments.

OBI employs 642 Oklahomans and works with 1,200 volunteers and 2,600 blood drive coordinators. Its donor centers are located in Ada, Ardmore, Edmond, Enid, Lawton, Norman, central Oklahoma City (Oklahoma Health Center), north Oklahoma City and Tulsa. Numerous mobile blood drives are conducted in conjunction with businesses, schools and civic groups each week across the state. Oklahoma Blood Institute is the state’s only affiliate of Be The Match®, the national marrow donor program. For more than 12,000 Americans each year, a marrow or stem cell transplant is the only hope for a cure of a life-threatening blood cancer or other blood disorder. For the past three years, OBI has ranked in the top performance tier, due to our abil-

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Terry Taylor, President 800 N. Research Parkway, Suite 400 Oklahoma City, OK 73103 Phone: (405) 271-2200 Website: www.oklahomahealthcenter.com The mission of the Foundation is to promote innovations in healthcare and science, and to serve as a connector between our member organizations, in order to raise awareness of the Oklahoma Health Center’s profile among business and governmental entities as a key driver of economic development. The Oklahoma Health Center (OHC) is unique, unlike any other medical center in the United States or even the world. With an annual economic impact of almost $3 billion in the greater Oklahoma City area, the OHC represents the second largest concentration of employees and students in Oklahoma — more than 17,000 —larger than a number of Oklahoma communities. Chartered in 1965, the Oklahoma Health Center Foundation, Inc. (OHCF) was established to assist the Oklahoma Health Center, and its 23 member entities, in matters of mutual physical, administrative and planning concerns. This assistance helps drive the OHC’s potential in attracting and developing biomedical and biotechnical industries in Oklahoma. From cutting-edge biotechnology companies to government, medical education, patient care and community support institutions, OHCF serves as the facilitator to 23 world-renowned organizations.

OHCF works closely with many aspects of the campus and its organizations, serving as a liaison between Federal, State, County and City governments by representing the various interests of the campus. OHCF is a founding member of the 10th Street Medical Business Corridor, a vital and stabilizing anchor to north downtown, which links the OHC campus to other medical facilities in the area, along 10th street. OHCF is responsible for the implementation of the campus Master Plan, which seeks to establish the Oklahoma Health Center as the primary destination for health care and education and the continued building of a campus that will sustain OHC’s status as a true major economic engine for the region. OHCF initiated campus beautification projects with the creation of parks and adding public art projects throughout the campus. The Treasures For Tomorrow program began in 2002, and almost $3 million has been raised. Projects include public art sculptures at Dean McGee Eye Institute and The Children’s Hospital, and Founders Plaza at Stiles Park featuring the Beacon of Hope. OHCF is involved in the plans for a modern and comprehensive way-finding signage project. Since 2000, more than $534 million in construction costs have been completed at the campus. OHCF continues to serve as a facilitator between developing agencies and their surrounding agencies, ensuring the successful and orderly growth of the campus. OHCF continues to serve the campus interests as a key stakeholder through meetings with the City of Oklahoma City in discussing the proposed MAPS 3 streetcar development and its potential service to the OHC.

OHCF continues to represent the interests of the OHC in the successful, revitalization development of downtown Oklahoma City by closely working with the City of Oklahoma City, the Greater OKC Chamber of Commerce and Downtown OKC, Inc.

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Michael Carolina, CEO 755 Research Parkway, Suite 110 Oklahoma City, OK 73104-3612 Local: (405)319-8400 Toll Free: 866-265-2215 In Tulsa: 618 East Third Street, Suite 5 Tulsa, OK 74120 918-576-7650 Website: www.ocast.ok.gov Facebook: www.facebook.com/ocast.ok.gov Twitter: www.twitter.com/ocast The Oklahoma Center for the Advancement of Science and Technology (OCAST) was established in 1987 as the state’s agency for technology-based economic development. OCAST’s mandate is to “expand and diversify Oklahoma’s economy and provide new and higher quality jobs for Oklahomans” by encouraging “. . . the development of new products, new processes and

whole new industries in Oklahoma.” (O.S. 74, Sections 5060.1a and 5060.2A) MISSION To foster innovation in existing and developing businesses • by supporting basic and applied research • by facilitating technology transfer between research laboratories and businesses • by providing seed capital for innovative firms in the development of new products or services • by helping Oklahoma’s small and medium-sized manufacturing firms become more competitive through increased productivity and modernization (O.S. 74, Section 5060.3) VISION OCAST funds cutting-edge science and technology through processes that are recognized nationally and internationally for demonstrating excellence, objectivity and economic impact. OCAST’s vision is continued growth and vitality of its basic premise of facilitating collaborations between state government, universities, start-up companies and established large-scale firms to develop an entrepreneurial environment which supports technologybased economic development. OCAST’s strategy includes technologies such as biosciences, information technology, sensors and electronics, advanced materials, energy and alternative fuel sources. Achieving this vision will result in continued growth of advanced technology companies in the state thereby increasing Oklahoma’s global competitiveness, per capita income and quality of life.

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MISSION Providing quality healthcare with compassion and concern for our patients. Our mission is to provide the highest quality medical care to all patients in an atmosphere conducive to the practice of good medicine. We strive to do this through our physicians who place the needs of their patients first and are committed to caring for families, neighborhoods, and communities across the state of Oklahoma. OUR HISTORY In 1919, a group of Oklahoma physicians returning from World War I, decided a new form of health care was needed in the Oklahoma City area. They envisioned this form of health care providing quality healthcare and services to all patients. These six (6) physicians incorporated their experiences from working together

John M. Bell, M.D. President Oklahoma City Clinic (Central Location) 701 NE 10th Street (East of 10th & Lincoln) Oklahoma City, OK 73104 Phone: (405) 280-5550 Website: www.okcclinic.com in the war to develop a specialty group practice. This practice, they believed would enable them to improve the efficiency and quality of care for their patients. This new concept was the beginning of our organization, The Oklahoma City Clinic (OCC). In 1978, the Clinic relocated to its present facility further enhancing its ability to offer medical care to residents throughout the state as well as in the Oklahoma City area. It has since opened four additional locations to better serve and provide convenience for our patients.

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Terri White ODMHSAS Commissioner 1200 N.E. 13th Street Oklahoma City, OK 73117 Phone: (405) 522-3878 Website: www.odmhsas.org

The Oklahoma Department of Mental Health and Substance Abuse Services is responsible for providing services to Oklahomans who are affected by mental illness and substance abuse. In fiscal year 2008, the department provided services to 64,465 individuals – an increase of nearly 3,600 individuals over the previous year. The demand for public mental health services exceeds the capacity of the current treatment system. This has always been the case, but has been exacerbated in recent years due to a growing public awareness of mental illness and of the existence of effective treatment; rising healthcare costs; and the state’s growing substance abuse problem, particularly the brain-damaging use of methamphetamine and resultant psychotic behavior. Through the use of proven practices and expansion of community based services, the department will increase the effectiveness of services and continue to improve the efficiency of the delivery system. The department’s goal is to ensure access to appropriate care for all Oklahomans and the recovery of all served.

In the mid-1970s, the concept of “deinstitutionalization” prompted states to increase efforts to utilize outpatient services through Community Mental Health Centers. This approach has proven to be an effective means of recovery and a less costly method to provide services as compared to long-term inpatient care in a hospital setting. Today, over 60,000 individuals receive services from the department each year. Of those, only about 5 percent require hospital care. The vast majority take part in mental health and substance abuse outpatient programs, targeted community based services, prevention efforts and educational initiatives. In fact, Oklahoma has become a national leader in several areas of community based services including the implementation of programs for assertive community treatment, alternative criminal justice initiatives such as drug and mental health courts, and comprehensive services for children and families. In many ways, Oklahoma already is “ahead of the curve” in terms of treatment success for people with mental illness or substance abuse problems. With a focus on community-based and proven practices, and emphasis on treatment across the lifespan, from children to the elderly, more Oklahomans with mental illness and substance abuse problems are being served than ever before.

The ODMHSAS was established through the Mental Health Law of 1953, although publicly supported services to Oklahomans with mental illness date back to early statehood. Until the mid-1960s, the primary means to treat mental illness was institutionalization in large state hospitals. On an average day in 1960, nearly 6,400 Oklahomans were in the state’s mental hospitals.

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Stephen M. Prescott, M. D., President 825 N.E. 13th Street Oklahoma City, OK 73104 Phone: (405)271-7400 Website: www.omrf.org JOBS at OMRF -- https://jobs.omrf.org/applicants/jsp/ shared/frameset/Frameset.jsp?time=1380829938244 What if there was a place solely focused on research? A place where collaboration could thrive and ideas could grow? Where the stage was set for life-changing discoveries? There is.

It’s the Oklahoma Medical Research Foundation. • OMRF scientists hold 700 US and international patents and have developed two FDA-approved drugs. • The Scientist magazine named OMRF among the “Best Places to Work” for postdocs and in academia in 2011, 2012 and 2013. • For our work on rheumatoid arthritis and lupus, the National Institutes of Health has designated OMRF as one of only nine Autoimmunity Centers of Excellence in the US. • Our internationally recognized cardiovascular biologists are studying how blood-vessel formation impacts heart disease and breast and colon cancer. • Researchers at OMRF have identified more than 25 genes associated with lupus and five linked to Sjögren’s syndrome. 28

• Physicians in OMRF’s Multiple Sclerosis Center of Excellence offer the region’s most comprehensive center for researching and treating MS. • OMRF is seeking novel methods of preventing age-related macular degeneration, hearing loss, osteoarthritis and diabetes. • For 12 consecutive years, OMRF has earned a four-star rating—the highest possible score—from Charity Navigator, America’s largest independent charity evaluator. • With 18 vertical wind turbines that generate 85,000 kilowatt hours of energy each year, OMRF’s research tower is home to the world’s largest wind farm. • Our new biorepository holds more than 1 million patient samples in a massive freezer that maintains a constant temperature of -112 degrees Fahrenheit. • Scientists at OMRF led the largest genetic experiment ever in the field of lupus research, working with 50 scientists in 6 countries to study biological samples gathered from 15,000 patients. • OMRF has discovered an experimental medication to treat a deadly form of brain cancer. The investigational new drug is currently in clinical trials. OMRF. Discoveries that make a difference.

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Oklahoma School of Science and Mathematics Frank Wang, Ph.D., President The Oklahoma School of Science and Mathematics 1141 North Lincoln Boulevard Oklahoma City, Oklahoma 73104 Phone: (405) 521.6436 Website: www.ossm.edu Only one of a handful of high schools of its kind in the nation, the Oklahoma School of Science and Mathematics is a unique learning institution for Oklahoma students. OSSM is Oklahoma’s public, tuition-free, residential high school for juniors and seniors with exceptional abilities in mathematics and science. The school’s residency program is designed to encourage an atmosphere of informal interaction among peers and foster each student’s highest potential. The availability of laboratories, along with evening and weekend programs of interest, challenge students and stimulate studies. OSSM was created by the Oklahoma Legislature in 1983 and is funded by the state. The school is governed by a Board of Trustees, which is appointed by legislative leaders and the governor. Although the history of the school is grand, the wonderfully gifted students are at the heart of OSSM. Since its inception 22 years ago, students have matriculated from all of Oklahoma’s 77 counties.

The campus is located on a 32-acre site near the state capitol and adjacent to the teaching and scientific research resources of the Oklahoma Health Center. In the summer of 2000, the school completed a $25 million campus building program. The classrooms and offices of the historic Lincoln School were restored through a unique partnership with Oklahoma patrons, organizations, businesses and government entities and is now called the Manning Academic Center. Students live in the school’s Dan Little Residence Hall that accommodates 144 students and faculty families. OSSM also has a gymnasium, Bernice Shedrick Library and Samson Science and Discovery Center, which houses physics and chemistry laboratories. The dormitory has expanded to allow the school to house 100+plus additional students per year should funding become available from the state to ensure the school’s future and keep the dream alive for Oklahoma’s best and brightest students. OSSM is committed to building a strong academic foundation for each student. While in residence at OSSM, students are required to complete successfully four and one-half units of science, two units of mathematics, one-half unit of computer science, two units of English, two units of history, two units of a foreign language, one unit of fine arts, and two units of physical education. Each science class features a two-or-three-hour weekly laboratory experience. Students receive five and onehalf days of academic instruction every week. Students must also receive satisfactory participation reports in both campus and community service and a total of 120 hours are required for graduation. The graduates of OSSM have already left their indelible marks on Oklahoma. Of the more than 1,300 OSSM graduates since the first class, 300 are engineers and nearly 100 are medical doctors. More than 50 have earned Ph.D.s and 75 have served in the U.S. armed forces. Eighty-five percent of these graduates have careers in science, math, engineering and technology. More than half now work or live in the state and 10 graduates have begun their own businesses in Oklahoma.

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Terry Cline, Ph.D. Commissioner 1000 N.E. 10th Oklahoma City, OK 73117 Phone: (405)271-4200 Website: www.health.ok.gov A Day in the Life of Public Health… From the time you get up in the morning till you go to bed at night, public health is involved in your life: • When you got up this morning, you made food choices for breakfast. We provide you messages on healthy food choices. • You have a yearning for that cigarette you are trying to give up. We work with the Oklahoma Tobacco Helpline to help you quit smoking. • Hopefully, you brushed your teeth. We work with communities to fluoridate water supplies. • You got in the car and buckled in your children, put the baby in the car seat, and buckled your own seatbelt. We encourage seat belt use and provide car seats to those who need them. • You dropped the kids off at school. All should have their mandated immunizations to protect them from childhood diseases. We provide immunizations. • You go to work where most of your colleagues seem to be sick. We investigate disease outbreaks. • You go to lunch at a local restaurant. We inspect food service facilities. • You decide not to go back to work – since everyone’s sick anyway – so you think you’ll get that tattoo you’ve been dreaming about. We license tattoo artists. • You decide to visit your grandmother to show off your new tattoo. She’s at a local nursing facility. We license nursing homes. • You pick the kids up from the after-school program. It’s one that works with the health department to 30

provide lots of physical activity and healthy snacks. • You stop off at the grocery store where you see a friend selecting fresh fruits and produce. You know she’s on WIC, the special nutrition program for women, infants and children. We administer the program. • You start to prepare dinner. You wash your fruits and vegetables to help prevent contamination from E. coli bacteria. The Public Health Laboratory analyzes food specimens during foodborne illness outbreaks. • Your sister calls and says she has enrolled in the Children First program. This is a special nurse visitation program provided by county health departments to visit first-time mothers in their home and teach them about caring for their new baby. • After dinner you go for a walk and let the kids ride their bikes. Public health partners with communities to encourage safe sidewalks and bike trails to promote physical activity. • While outside, you make sure everyone has used insect repellent containing DEET to prevent mosquito bites and tick bites. We investigate cases of West Nile virus caused by mosquito bites, and Rocky Mountain spotted fever, caused by tick bites. • You put the baby to bed in a crib that meets current federal safety standards and is free of bumper pads so the baby cannot suffocate. You place the baby on its back, the safest position. We provide education on child safety. • On the 10 o’clock television news, you learn that HIV continues to be of concern in Oklahoma. Public health provides testing for HIV. • Overnight, a tornado hits your community. When you turn on the radio the next morning, you hear messages that your local health department will be providing tetanus shots for those involved in the cleanup. So indeed, public health is at work every day to keep Oklahomans healthy!

Charles L. Spicer, Jr.,

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FACHE President and Chief Executive Officer of OU Medical System

Jon Hayes, MHA, CMPE Chief Executive Officer of The Children’s Hospital at OU Medical Center

OU Medical Center

700 NE 13th, Oklahoma City, OK 73104 www.oumedicine.com/oumedicalcenter Follow us on Twitter at @oumedicine Like us on Facebook at www.facebook.com/oumedicine

The Children’s Hospital at OU Medical Center 1200 N Children’s Ave. (formerly Phillips Ave.), Oklahoma City, OK 73104 www.oumedicine.com/childrens Like Children’s on Facebook at www.facebook.com/OKChildrens For career information, visit www.oumedicine.com/careers OU MEDICAL CENTER—Oklahoma City’s largest and most comprehensive hospital—is the major referral center in central and western Oklahoma for adults and children. We provide a full range of hospital services for every patient, from the smallest neonate to the most critically ill senior. We’ve been in the community for more than 100 years, and envision the next century to be as productive as the first as we grow with our city and community. With more specialists in more fields than any other hospital in the state, we’re making sure Oklahomans are alive and well. Our adult services boast an award-winning tradition of applying innovative treatments to the care of patients in a full range of specialties, including the state’s only Level One Trauma Center and one of the first certified comprehensive stroke centers in the country. OU Medical Center is recognized for its excellence in neurology and neurosurgery, sleep disorders, orthopedics, cancer treatment, critical care and many other areas. Our patients have the advantage of being cared for by some of the premier experts in their field of medicine. Our staff

works as a team, leading health care and taking what we do to another level of medicine. The Children’s Hospital at OU Medical Center is Oklahoma’s only comprehensive, freestanding pediatric medical center where pediatricians, pediatric specialists and pediatric sub-specialists have been caring for Oklahoma’s children for nearly 90 years. Children’s is home to Oklahoma’s only pediatric emergency department, and has the state’s largest staff of Child Life specialists who help promote development and minimize the stress of hospitalization. For expectant families we offer care in our Women’s & Newborn Center at Children’s Hospital. From the easiest of pregnancies to the most complicated, our staff is experienced in caring for mothers and babies. If a baby needs extra care, she is an elevator ride away from the highest level Neonatal Intensive Care Unit in the state. The Children’s Hospital provides medical care found nowhere else, and excels in specialties like cancer, orthopedics, urology, epilepsy and heart disease. Our staff and affiliated physicians train tomorrow’s health care professionals, conducting innovative medical research and providing compassionate, quality patient care. Oklahoma City is alive and well, and OU Medicine is at its heart.

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1200 N. Phillips Ave., Suite 2900 Oklahoma City, OK 73104 Phone: (405) 271-3932 Website: www.oumedicine.com OU Physicians is part of OU Medicine, combining academic knowledge and advanced health care. With more than 560 doctors, OU Physicians is the state’s largest physician group. The practice encompasses almost every adult and child specialty. Many OU Physicians have expertise in the management of complex conditions that is unavailable anywhere else in the state, region or sometimes even the nation. Some have pioneered surgical procedures or innovations in patient care that are world firsts and many are conducting groundbreaking research to develop new treatments and cures. More than 175 of our doctors are OU Children’s Physicians. The majority of them are board-certified in children’s specialties, and many provide pediatric-specific services unavailable elsewhere in the state. Many children with birth defects, critical injuries or serious diseases who can’t be helped elsewhere come to OU Children’s Physicians. Oklahoma doctors and parents rely on OU Children’s Physicians depth of experience, nationally renowned expertise and sensitivity to children’s emotional needs. In 2009, OU Children’s Physicians opened a new state-ofthe-art facility on the OU Health Sciences Center campus. A year and a half later, the Children’s Atrium was opened creating a new entrance to not only the children’s physician offices, but the hospital as well. The following year, the final piece of this construction project was completed with the opening of the Samis Education Center, further enhancing the campus’ ability to provide the highest quality education services to faculty, staff and students. Many OU Physicians see patients through specialty centers like The Peggy and Charles Stephenson Cancer Center and Harold Hamm Diabetes Center. The Cancer Center building represents the largest public-private biomedical initiative in Oklahoma history. The 210,000 square-foot facility provides

Brian Lynn Office Brian Maddy, Chief Executive Officer and Lynn Mitchell, M.D., Chief Medical Officer patient-center care, offering the most advanced cancer detection and treatment technology, the largest and most experienced group of cancer specialists, a wide array of supportive services and an environment that provides a warm and comforting experience for patients and caregivers. Members of the Cancer Center - including faculty from OU Health Sciences Center, OU Norman, OU Tulsa, Oklahoma State University and the Oklahoma Medical Research Foundation - conduct innovative and nationally-funded cancer research in the basic, clinical and population sciences. Harold Hamm serves as the focal point for coordinating and expanding numerous avenues of research, patient care, education and prevention that are required to address the diabetes epidemic in a comprehensive manner. The Center offers outreach efforts throughout the state, partnering with communities and other agencies both inside and outside the University of Oklahoma. The Center was established by the University of Oklahoma with the goal of promoting the wellbeing of all people with or at high risk for diabetes in Oklahoma, regardless of ethnic background or financial status. OU Physicians see patients in their offices at the OU Health Sciences Center and in Edmond, Midwest City and other cities around Oklahoma. When hospitalization is necessary, they often admit patients to OU Medical Center. Many also care for their patients in other hospitals around the metro area. OU Physicians serve as faculty at the University of Oklahoma College of Medicine and train the region’s future physicians. For more information about OU Medicine, including OU Physicians and OU Children’s Physicians, go to www.oumedicine.com. OU Physicians faculty and staff are employed by the University of Oklahoma, one of Oklahoma’s largest employers. The university attracts leading faculty and staff from around the world. To view job opportunities within OU Physicians, go to this site: www.oumedicine.com/ouphysicians/job-opportunities

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Tom Gray, President & CEO 655 Research Parkway, Suite 500 Oklahoma City, OK 73104 Phone: 405-319-8150 Fax: 405-319-8168 Website: www.phfokc.com Founded in 1985 with the vision of creating a premier medical center in Oklahoma City, the Presbyterian Health Foundation has invested over $118 million in medical education and research in Oklahoma. This investment has led to medical breakthroughs which touch the lives of individuals and families in communities across the state and nation. It has also brought exciting economic opportunities by positioning Oklahoma at the forefront of genetic research and biotechnology. Proceeds from the 1985 sale of the Presbyterian Hospital were used to create a foundation which would enhance medical research and education in the state of Oklahoma. Trustees of the Presbyterian Hospital continued with the newly formed foundation and believed the potential for excellent health could become the norm, rather than the exception, for all people. Nearly 30 years later, Trustees of the Foundation continue to share a set of values, expectations, and modes of behavior refined under strong leadership and forged by a long history of success that has made a tremendous impact on the people of Oklahoma.

Over the last decade, Presbyterian Health Foundation developed the PHF Research Park which contains 700,000 square feet of wet lab and office space and provides a place for researchers to translate discovery to solutions, putting science to work solving a specific human health need. Following the 2013 sale of the PHF Research Park to the University of Oklahoma, the Foundation has returned to focusing its efforts on supporting scientific research and medical education at the Oklahoma Health Center Campus. The purpose of the foundation is to provide resources and to encourage the development of medical education and research programs, conducted primarily in Oklahoma. The Foundation concentrates its support in four areas: • Medical Research • Medical Education • Community Health Programs • Technology Transfer Researchers, mentors, administrators and leaders in biotech companies are all part of a community of people who bring to life the ideas of PHF’s mission. PHF will continue its mission to support excellent biomedical science where discovery may be translated to therapies that save and enhance human life. Today, the disclosures in good science, evidenced based knowledge, yield brand new widened horizons of human existence.

Member

Serving Children and Families since 1984

Susan Adams, President & Chief Executive Officer 1301 NE 14th Street Oklahoma City, OK 73117 Phone: (405) 424-6873 Family Room phone (405) 271-2215 Website: www.rmhokc.org When a child is hospitalized or receiving ongoing medical treatment, we believe the love and support of family is as powerful as the strongest medicine. Unfortunately for most parents, being with a hospitalized child means eating out of vending machines and sleeping in chairs or bearing the expense of hotel rooms. That is why Ronald McDonald House Charities® of Oklahoma City is here. Keeping families together . . . when they need it most At 78% of the world’s leading children’s hospitals, families benefit from at least one RMHC Core Program. The Children’s Hospital is served by the 15-BR Ronald McDonald House which has been located at NE 14th St and Lottie for 30 years. • At our House, families can have a bedroom of their own with a comfortable bed, a family-style kitchen

with home-cooked meals, and laundry facilities for their personal use. • Worried moms and dads can talk to one another, sharing their hopes and fears. • For the child who is sick or injured, having a Ronald McDonald House means that they can rest easier, knowing that mom and dad are nearby. The Ronald McDonald Family Room®, located on the sixth floor of The Children’s Hospital, opened in 2008 for dayuse respite services. Parents can relax and regroup just steps away from their child’s bedside.

The positive, comforting environment of both facilities allows the families to focus on their children’s healing process. Services are available to any family with a child 21 years of age or younger receiving medical treatment in Oklahoma City area, regardless of their economic status. Ronald McDonald House Charities of Oklahoma City relies on donors and the community for support of daily operations. No family is ever turned away due to the lack of finances.

The organization offers career opportunities within the charity, at the House and Family Room to help with the daily operations. For open positions, please visit www.rmhcokc.org/contact/careers. Interested candidates should submit a resume to careers@rmhcokc.org.

Member

Dean Gandy, Chief Executive Officer University Hospitals Authority & Trust PO Box 26307 Oklahoma City, OK 73126 Phone: 405-271-4962 Website: www.universityhospitalsauthority.com The University Hospitals Authority and Trust are a state agency and a public trust of the state of Oklahoma. Key facts: • Formed as part of an historic agreement more than a decade and a half ago that united the state, a private corporation (HCA) and the University of Oklahoma in a partnership that created the OU Medical Center and united the adult hospitals with The Children’s Hospital at OU Medical Center. • Mission - To be a catalyst for medical excellence, to support medical education and research and to help assure quality health care for all Oklahomans. • Through its leadership, state and federal resources are maximized to ensure a dependable source of revenue for growth and development with a goal of supporting improved health for every Oklahoman. • The Authority and Trust provide support for important educational enhancements, for key research and health care advancements and for critical capital improvement projects at the OU Health Sciences Center Key projects funded to date include: • Construction of the new Children’s Atrium. This beautiful, architectural gem will serve as a new front door for The Children’s Hospital at OU Medical Center and the OU Children’s Physicians Building, as well as a unique space catering to the young patients of both facilities and their families. • Construction of Samis Education & Conference Center for the OUHSC campus, completed in 2012. It’s three-story design provides state-of-the-art meeting rooms, board rooms and auditorium space to accommodate a wide variety of meeting needs. • Support of facility enhancement and expansion project for Dean McGee Eye Institute

• The OU Children’s Physicians Building, completed in 2009. Located at the corner of NE 13th and Phillips, it provides 336,000 square feet of state-of-theart medical office space designed specifically with the needs of young patients and their families in mind. It is home to more than 100 pediatric specialists and the first free-standing first, freestanding, pediatric multi-specialty, medical office building in the state. • Support of the new Clinical Skills Testing and Education Center at the OU Health Sciences Center, in conjunction with other generous donors. This facility offers cutting-edge medical simulation equipment and facilities, as well as a new robot-assisted surgical training facility. • Support of Phase Two of the Stanton L. Young Biomedical Research Center. A hub of research of activity on campus, the facility more than doubled in size with the completion of phase two, providing more research space where top scientists continue their nationally and internationally renowned work in biomedicine, cancer, genetics and more. • The OU Physicians Building, completed in 2001. Located at the corner of NE 10th and Phillips, the OU Physicians Building is home to more than 130 physicians, with expertise in a wide range of medical specialties. The building provides an environment where patient care and the newest technology come together under one roof. • A facility enhancement project for the OU College of Dentistry that included much-needed upgrades and technological enhancements aimed at elevating the training of Oklahoma’s future dentists to a new level of excellence.

Member

Jason R. Sanders, MD Senior Vice President and Provost P.O. Box 26901, LIB 221 Oklahoma City, OK 73126 Phone: (405) 271-3223 Website: www.ouhsc.edu

In education, research and patient care, the University of Oklahoma Health Sciences Center is the state’s premier academic health center and regional leader in meeting the challenges of 21st-century health care. The most concentrated source of medical expertise in Oklahoma, the OU Health Sciences Center’s new facilities and new technology -- plus an internationally prominent faculty -- place it at the leading edge of the nation’s institutions of medical education. One of only four comprehensive academic health centers in the nation with seven professional schools, the OU Health Sciences Center serves more than 3,800 students enrolled in more than 70 health professions, graduate and undergraduate programs on the Oklahoma City campus and at the Schusterman Center at the University of Oklahoma-Tulsa. In addition, more than 700 physicians are receiving residency training in Oklahoma City and Tulsa. Research, training grants and contracts, and sponsored program activities at the OU Health Sciences Center totaled more than $120 million

in FY 2013. With a budget of over $870 million, OUHSC employs more than 1,200 full time faculty and 4,000 staff. More than half of all NIH expenditures in the state of Oklahoma result from OU Health Sciences Center research. The OU Health Sciences Center serves as the state’s training facility for physicians, biomedical scientists, nurses, dentists, pharmacists and a wide range of allied health and public health professionals. The OU Health Sciences Center is known for its research programs in cellular and molecular medicine, gene regulation, structural biology, cancer, diabetes, microbiology and immunology, vision, cardiovascular physiology, neuroscience and pharmaceutical sciences. The center’s growing faculty and facilities offer unparalleled opportunities for students, patient care and the development of the biomedical industry in Oklahoma. OU Health Sciences Center-developed technology is advancing the economy of Oklahoma. Companies that commercialize technology created by OU Health Sciences Center researchers have been established in Oklahoma City. OU has become one of the primary centers in the world for genome studies, with the Norman campus contributing to the human genome project and the OUHSC campus providing a number of microbial pathogen genomes. The OU Health Sciences Center ranks second in the world for the number of microbial genomes being sequenced.

Two-thirds of all Oklahoma physicians, half of the state’s dentists and a significant percentage of Oklahoma’s other health care professionals earned their degrees from the OU Health Sciences Center. In addition, the seven OU Health Sciences Center colleges are the primary source of continuing education for the state’s health care professionals.

Member

The scientists, scholars and clinicians appointed to the OU Health Sciences Center faculty stand at the leading edge of their profession. They not only train the next generation of health care providers and researchers,

With cancer being one of the leading causes of death in the United States, The Peggy and Charles Stephenson Cancer Center opened in June 2011. This cancer center allows the people of Oklahoma to receive world-class treatment without leaving the state and is staffed with some of the nation’s finest cancer physicians. It offers state-of-the-art technology, unparalleled cancer research programs, and bench-to-bedside care.

many are themselves practicing professionals actively involved in improving the lives and health of Oklahomans. The clinical practice of the OU College of Medicine is provided through OU Physicians. These physicians represent the largest multi-specialty medical group in the state with more than 500 physicians, offering almost every adult and child specialty. OU Physicians accepts referrals from across the state and region and care for hospital patients at the OU Medical Center. OU Children’s Physicians is an integral part of OU Physicians.

The Harold Hamm Diabetes Center is a comprehensive treatment, research, and educational facility dedicated to eliminating and controlling the effects of all types of diabetes. The Diabetes Center is at the forefront in diabetes-related research, and OUHSC physician researchers are specialists in diabetes care and utilize cutting edge research for the best treatment available research.

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