BELGIAN RESEARCH 2020

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An amazing place to develop the vaccines of tomorrow GSK is the world’s leading vaccine company, with a portfolio that helps to protect people throughout life, and an innovative pipeline of 15 vaccines in development. We deliver over 2 million vaccine doses per day to people in more than 160 countries. According to the World Health Organization (WHO), only clean water rivals vaccination in its ability to save lives.

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SK Vaccines has developed vaccines against 21 of the 31 diseases currently preventable by vaccination to help protect people at all stages of their life. Over the last ten years, in Belgium, this division invested €3 billion in infrastructure and capacity building. Furthermore, GSK Vaccines has become the largest pharmaceutical company in Belgium with >9,000 employees. Our vaccine scientists work in three global R&D centers in Rixensart (Belgium), Italy and the US. In 2019, we invested about €1 billion in vaccines R&D.

CureVac make it possible to identify a genetic code of an antigen (the active ingredient of the vaccine), to generate a candidate vaccine more quickly – a revolution for the manufacturing phase.

© GSK Vaccines

GSK Vaccines has defined its R&D key priorities: increasing our portfolio of new vaccines against a respiratory virus (RSV) – a leading cause of bronchiolitis in babies and pneumonia in adults, reducing antibiotic resistance (AMR) through disease prevention, therapeutic vacDr Emmanuel Hanon, cines and personalized vaccines. To achieve Senior Vice President of Vaccine Research GSK Vaccines relies upon partnership and a this goal, GSK Vaccines leverages digitalization, at GSK Vaccines 100-year legacy of vaccine development that artificial intelligence, and machine learning to enabled frontline innovation in areas such as recombinant vaccines, design vaccine antigens and measure their broader benefit to pediatric vaccines, vaccines with new adjuvants, vaccines against society through health data analysis. respiratory and meningococcal diseases, pandemic vaccines, and a vaccine against herpes zoster. Collaborations with external partners (Belgian universities, the NIH in United States, biotech companies, the European Commission through the Innovative Medicines Initiative or IMI) are a core part of the R&D culture.

© GSK Vaccines

In 2020, the year of the COVID-19 pandemic, we are working with others on several COVID-19 vaccine candidates contributing our pandemic adjuvant technology (developed in Rixensart). An adjuvant is added to some vaccines to enhance the immune response, thereby creating a stronger and longer lasting immunity against infections than the vaccine alone. The use of an adjuvant is of particular importance in a pandemic situation since it can reduce the amount of antigen required per dose, allowing more vaccine doses to be produced and made available to more people. Our site in Wavre, Belgium, the largest vaccine manufacturing site worldwide, will also contribute to the manufacturing of up to 1 billion adjuvant doses for our COVID-19 collaborations in 2021.

GSK site in Wavre – largest vaccine manufacturing site worldwide

GSK is currently undergoing a two-year programme to separate into two companies: one leading biopharma company, and another company focusing on consumer healthcare activities. Experts and teams across GSK pharma and vaccines will thus build upon a common approach to R&D in order to deliver transformational vaccines and medicines. Moreover, the Vaccines division is innovating in therapeutic vaccines: next generation of vaccines could play a strong role to slow down or stop disease progression, or even act as a cure for a disease. They could become an important tool in reducing the spread of antibiotic resistance and anti-microbial resistance globally.

© GSK Vaccines

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GSK

GSK site in Rixensart – historical vaccine Research & Development site

GlaxoSmithKline Vaccines

Additionally, GSK Vaccines strives to significantly accelerate the vaccine development times thanks to potential breakthroughs including mRNA platform technologies. Our self-amplifying RNA (SAM) platform or our collaboration with a global mRNA leader

Avenue Fleming 20 - 1300 Wavre Email: elisabeth.e.vandamme@gsk.com (external communication for GSK in Belgium) https://be.gsk.com 116


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True proximity between clinicians and researchers at the heart of the Charleroi CHU (University Hospital Centre

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183

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Alternative methods to deal with new toxins

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INFOPOLE Cluster TIC The Walloon network of digital stakeholders at the service of innovation

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CREMAN - Nuclear Magnetic Resonance Centre A well-informed partner of the industrial innovations of tomorrow

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Aerospace and Mechanical Engineering Department – ULiège Cutting-edge research and industrial applications join forces

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Liège Space Centre – CSL Developing space technologies

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Chemical Engineering Research Unit – Liege University (ULiège) Working towards sustainable transformation processes

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163

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Center for Education and Research on Macromolecules - CERM Polymers to serve coatings, biomaterials and energy

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StratiCELL Smart science dedicated to healthcare

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SOWALFIN, a key innovation stakeholder in Wallonia

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PDC*line Pharma Your partner in immuno-oncology

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Quality Assistance Analytical expertise for tomorrow’s innovative medicines

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Medi-Line A medical devices expert

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GSK Vaccines An amazing place to create the future

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Miracor Medical SA Cutting-edge cardiac care

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AbbVie Transforming patients' lives

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Dendrogenix A new family of molecules that fight deafness and cancer

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The leading expert in the tumour microenvironment

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131

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Interview with Mr Julien Compère, CEO of University Hospital of Liege (CHU Liège

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Accessia Pharma Provide efficient tools to grow

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Maximising the participation of Walloon stakeholders in European research programmes

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Sizeable investments for the life sciences

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SRIW, a key partner in the regional strategy for plastic recycling & circular economy

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Bridge2Health - B2H Providing solutions leveraging excellence

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Agoria Wallonia brings the technology industry into the 4.0 era

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Industry as the main source of technological progress

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Pro-Rector for Research at UCLouvain

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Haute Ecole Lucia de Brouckère Bachelor’s in medical electronics: a cutting-edge course as a response to the increasing demand for specialist technicians

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Haute Ecole Lucia de Brouckère Master’s in Industrial Engineering Sciences: a highly practical course that integrates research and the needs of the industrial world

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Breast International Group (BIG): the power of international collaboration in cancer research

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A widely recognized expertise in interdisciplinarity

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Queen Fabiola Children’s University Hospital – HUDERF Ensuring optimal development of young children

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The central nervous system and neuroprotection as weapons in the fight against multiple sclerosis

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The Center for Research in Cognition & Neurosciences

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Recognised expert in aquaporins in Sjögren’s syndrome

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treatment of Alzheimer’s disease

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Teresinha Leal’s research on the identification of biomarkers in the sweat gland to evaluate the efficacy of treatment of Cystic Fibrosis

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Regenerative medicine to treat liver diseases

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Sabine Costagliola Lab (IRIBHM-ULB) Expert in thyroid development disorders

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RNA epigenetics in the battle against cancer

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Brussels Polytechnic School – EPB A well-renowned training course to reflect proven global standing

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The 4MAT Department The Specialist in Inorganic Materials

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Vrije Universiteit Brussel - VUB Research and innovation for health

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Université Libre de Bruxelles - ULB Interdisciplinary and interregional research for the benefit of health

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Interview with Prof. Alban de KERCHOVE d’EXAERDE, Research Director at the Laboratory of Neurophysiology of the Faculty of Medicine of the Université Libre of Brussels, President of the Belgian Society of Neuroscience, Vice-President of the Brussels Commissionon Animal Experimentation

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Bayer A pharmaceutical company focusing on innovation to improve patient’s quality of life and answer unmet medical needs

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Alcon A global leader in eye care

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Bolstering the appeal of ULB research centres at a global level

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NVS Consulting Your consultancy partner in clinical research on medicines and medical devices

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Nestlé Strong environmental responsibility

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Towards a more open and innovative Brussels’ economy

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Nestlé Health Sciences A strong player in medical nutrition and consumer care

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pharma.be: Belgium, an innovative pharmavalley in Europe

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Accelerating innovation in medical devices and e-health for patients and healthcare providers

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MedTech Accelerator® Stimulating innovation in medical technologies

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AZ Groeninge implements new care model from a holistic approach

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Better measure the heterogeneity of inflammatory breast cancer

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AZ Jan Palfijn Gent Already two pregnancies after brand new Corona test at IVF

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Clinical research at UZ Gent: a focus on patient-oriented, personalized medicine

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Biotronik A leader in the field of cardiovascular devices

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Arseus Medical Group Innovative solutions for health professionals

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Fujirebio Europe A pioneer in the field of Alzheimer diagnostics

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ProDigest Specialists in intestinal research

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PharmAbs The KU Leuven Antibody Center

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VAXXIUM Your partner for the development of new vaccines

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ECSOR Expertise at the service of clinical research

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VIB: Excellence-driven basic research in life sciences with a strong societal impact

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Ecosynth NV Your partner for sustainable molecule and process development

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UZ Leuven - University Hospitals Leuven High-level research

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Becetel: high-performance materials research for industry and the public sector

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imec, a world-leading research and innovation hub in nanoelectronics and digital technologies

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Becetel: Belgian research centre for pipes and fittings

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VITO Reducing the risk of sustainable innovation for companies

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Flemish universities must get the necessary means to remain appealing

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VLAIO: a one-stop-shop for entrepreneurs in Flanders

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Improving everyone’s quality of life

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