NSWO Year in Review 2021

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NSWO Dutch

Sleep Research Year in review 2021

N E D E R L A N D S E V E R E N I G I N G V O O R S L A A P / WA A K - O N D E R Z O E K ( N S W O )

NSWO

D U T C H S O C I E T Y F O R S L E E P / WA K E R E S E A R C H


Content 3 4 6 8 10 20 20 23 27 29 31 34 35 40 42 48

Preface Sleep in the news S l e e p s c i e n c e t o p i c s : C o v i d -19 & S l e e p Interview: leaving board members Hora est! Doctoral dissertations 2021 Dutch year in review 2021 Sleep mechanisms Circadian clock Sleep across the lifespan Sleep diagnostics and technolog y I n s o m n i a Narcolepsy & hypersomnia Sleep & breathing Parasomnias & movement disorders Sleep & physical health Sleep & mental health

Colofon NSWO Board (2021)

Ye a r in Re v ie w w or k g r o up

President Ysbrand van der Wer f

Jeanine Kamphuis

Secretar y Ar thur Kur vers

Karin van Rijn

Tr e a s u r e r E s m e e V e r w i j k

Shosha Peersmann

Chair scientific committee Annemarie Luik

Floor van Oosterhout

Chair PR committee Karin van Rijn Chair education committee Nikki Ant ypa

Cover photography

Chair young scientist committee Jari Gool

Cor Kuyvenhoven Oscar Bos

Scientific committee (2021)

Floor van Oosterhout

Denise Bijlenga Jeanine Kamphuis

Illus trations on page 25+33+41

Annemarie Luik

Sharina Bargerbos

Raymond Noordam Sebastiaan Overeem

Design

Maaike van Veen

Ellen Lennar t z

Floor van Oosterhout


Preface

D

ear members,

As we slowly come out of the corona pandemic, we are happy to take this time to highlight the work that has been done in the past year 2021 in the field of sleep research and sleep care. It is heartening to see that, as life goes on despite the circumstances, so does the work. Collaborations have persisted and new ones have even originated, meetings and conferences have been held in online and hybrid forms. This overview shows the tremendous productivity of our national sleep professionals, and their impressive output. The NSWO has hosted our annual spring symposium in 2021, and witnessed the success of our bi-annual national sleep conference with more than 400 registrations. In 2022 the education committee and the young scientist committee jointly organise the spring symposium on the topic of ‘wearables’ (May) and we are the host, together with the SVNL, for the International Sleep Medicine Course ISMC (June). At the WorldSleep meeting in Rome in March 2022, and the upcoming ESRS meeting in Athens in September 2022, our national sleep professionals contribute with numerous symposia and presentations. Sleep science in the Netherlands is alive and well, and expanding. We hope the renewed possibilities for meeting up, exchanging ideas, brainstorming and interacting will lead to even more collaborations and initiatives, from fundamental studies to clinical advances. All the best, Ysbr and D. van der Wer f President NSWO

Pag. 3


Sleep in the news

Dutch sleep congress

On November 25-26, 2021, the fourth bi-annual SLAAP2021 conference took place. For the first time via an online platform due to the COVID-19 pandemic restrictions. The conference was kicked-off from a professional broadcasting studio by Ysbrand van der Werf and Gert Jan Lammers, presidents of the organizing societies NSWO and SVNL, respectively, after which a variety of interesting symposia started. Highlight of the first day was the keynote lecture about the evolution of sleep in the octopus by Sylvia Lima de Souza Medeiros from Brazil, where she explained about the fascinating observation of two different and alternating stages of sleep in the octopus, one of which with dynamic skin colour and texture and rapid eye movements, resembling our REM sleep. A session on ‘sleep in times of COVID-19’ with international speakers such as Jason Ellis and Philip Cheng, could not miss in the program this year. An interesting finding was that patients who were treated for insomnia prior to the pandemic, were also more resilient Pag. 4

in keeping up their good sleep during the pandemic.The second day entailed many interesting lectures, but gave also room to the ‘general meeting of members’ (ALV) of the several associations and organizations involved in sleep. Some ALV’s were connected to a lecture, such as in the association for children and sleep (Vereniging Kind & Slaap): the invited Australian speaker Pamela Douglas presented from downunder about innovative techniques to support parents with their newborns’ sleep. At the second day there was an interesting keynote about the role of sleep and chrononutrition by Prof. Andries Kalsbeek, explaining how sleep/wake rhythms and metabolism are related and why meal timing really does matter. In this online format conference, there was a poster session, by which participants could visit the poster on the platform and log into Zoom to ask their questions to the presenters. At the end of day two the poster prizes were awarded: the Piet Visser Poster Price went to Alja Bijlsma for her poster about “Parental reported sleep after very preterm compared to full-term birth: a cohort study in early childhood”, for which she won an exchange trophy and a scholarship. The audience prize was awarded to Danique Heemskerk for her colourful poster entitled: “Sleep is a waste of time!? Understanding adolescent sleep health from a systems science perspective using causal loop diagrams”. The conference ended with a virtual social meeting in an actual virtual theatre in which participants could walk and talk with their avatars… Well, nothing beats meetingup face to face, but participants look back at a very succesful online conference in which many professionals participated, acknowledging the importance of sleep and putting sleep research and sleep care on the map in the Netherlands!


‘De slapelozen’

Time for sleep A selection of Dutch scientists and clinicians, who have made their fascination for sleep their profession, sacrificed some hours of their own sleep to prepare a readable colourful booklet for the general Dutch public to learn about sleep. The booklet called “Tijd voor Slaap” was published in the ‘Cahier’ series of the Dutch Foundation for Biosciences and Society (Stichting Biowetenschappen en Maatschappij, BWM) and is freely available as a pdf (www.biomaatschappij.nl/cahiers). In four chapters, the reader is taken by the hand in comprehensible Dutch language to learn about many facets and faces of sleep. Chapter 1 introduces sleep across the animal kingdom and how we measure sleep, discusses how sleep in the Dutch population changes from childhood to old age, including sleep-related issues ranging from cot death to poor sleep in menopause and old age. Chapter 2 illustrates the importance of good sleep by discussing its many functions. Chapter 3 then discusse how good sleep may be sacrificed by inappropriate environmental exposure and behaviour. Chapter 4 complements causes of poor sleep by discussing the several sleep disorders. Finally, and important for the general public, the Cahier provides a list of suggestions to keep sleep well. The booklet has been well received and has become a valuable source of information for the increasing number of people realizing that there’s more to life than being awake and that there’s more to health than exercise and an appropriate diet and body weight. We can be thankful and proud that our scientists and clinicians have joined forces to prepare this valuable booklet.

In the summer of 2021 (August 8 – 12), several

#1 “Kracht” #2 “Liefde” #3 “Ritme” #4 “Troost” #5 “Stilte”

-

with Merlijn van de Laar with Sigrid Pillen with Marijke Gordijn with Ingrid Verbeek with Aline Kruit

Stichting Biowetenschappen en Maatschappij

Find the link to watch here

Tijd voor slaap

sleep professionals were fighting against their sleep and biological rhythm by participating in the radio program “De Slapelozen”, presented by radio producer Frits Spits, broadcasted live between 2h-4h in the night for five nights in a row. In the program, radio listeners tell their night stories and sleep experts and psychologists are interviewed about sleep and sleepiness, alternated with poems and encouraging music in the middle of the night. The program follows people who have actively chosen for a night life, such as shift-workers, creative artists, DJ’s or caregivers, but also people who often find themselves lying in the bed wide awake while they would love to sleep. Also Frits Spits himself shared that, particularly since the death of his wife, he has experienced what insomnia is. ‘Sometimes it is a battle with the digital clock on the bedside table. It is so difficult to fall asleep again’. Sleep professionals from our field contributed to the experiences of sleepless people with valuable background information and answering questions from Frits Spits and listeners. They carefully explained about different topics like the functions of sleep, dreaming, sleep behaviour and biological rhythms. The radio settings were filmed, completed with short documentaries of people’s stories, and broadcasted as a TV series by NPO2 later in the year (Nov 29 – Dec 3), where we could eye witness the nightly soft light setting in Frits Spits’ intimate radio studio. Where the sleepless meet each other…

Geheimen achter gesloten ogen

Tijd voor slaap biowetenschappen en m a at schappij

k war ta al 1

2021

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Sleep science topics

Covid 19 & Sleep

I

n 2021 the NSWO started a series of interviews about a relevant topic in sleep science. Here we present our first guest. For further reading on the topic or scientist, check our website.

H E I D I L A M M E R S VA N D E N H O L S T SENIOR RESE ARCHER AT T HE ER ASMUS MEDICAL CEN T RE

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Since the COVID-19 pandemic, it has become clearer than ever: sleep is not a luxury, it is a necessity. The year 2021 was still dominated and impacted by COVID-19 infections and societal lockdown rules. This uncommon situation was topic of several research projects investigating the impact on sleep and the reciprocal relationship between infection and sleep. Heidi Lammers-Van der Holst, senior researcher at the Erasmus Medical Centre, was interviewed about her research in relation to COVID-19. Her international scientific career focuses on the relationship between sleep, biological clock and shift work. With that respect, the question arose whether COVID-19 vaccinations are less effective for people who sleep too little and work in a night shift. A topic that was more relevant in 2021 than ever, as night shift workers are more likely to contract


COVID-19, whereas we also really needed these people to help combat the pandemic. The protocol proposal was published in the Journal of Sleep Research in 2021 and the study results are expected in 2022. With her applied research and consultancy work, Heidi contributes to optimal sleep habits and the health of shift workers. Below, Heidi cites three reasons why a good night’s sleep is so important.

Sleep protects ‘It has been known already for some time: you strengthen your immune system by sleeping well and you are less likely to be infected by a virus. When you are sleeping, you produce more white blood cells and these cells produce cytokines, the messengers of your immune system. And, as a study conducted in 2015 shows, this protects against, for example, viral infections. In this study, 153 people were infected in a laboratory with the rhinovirus, a common viral infection. These people had monitored how well they slept during the 14 days prior to being infected. And indeed, it turned out that lack of sleep increased the likelihood of catching a cold. People who slept less than seven hours, even had a nearly three times higher probability to come down with a cold than people who slept at least eight hours. A larger-scale study in 2016 confirmed these findings. Over 22,000 people, whose sleeping habits were known, indicated whether they had suffered a respiratory infection in the past month. Here again, the conclusion was that those who slept well (at least 7-8 hours) were sick less often. So, does a good night’s sleep also protect against COVID-19? It looks that way. Recent studies show that healthcare workers, who sleep long enough, are less likely to contract a COVID-19 infection. However, there are still many unanswered questions. We are awaiting the results of additional studies, so that we can find out more about the relationship between sleep and the risk of contracting COVID-19.’

Caught a cold nevertheless? Sleep helps you recover ‘A good night’s sleep not only protects you, but if you do catch a cold nevertheless, sleep will help you to recover faster and better. This is also apparent from a study in 2020 of 164 people who were hospitalised after contracting COVID-19. They were asked to fill in a telephone questionnaire about

Sleeping is not only essential to repair the damage caused by viruses, but it also helps your body repair wounds

their lifestyle in the week before they fell ill. A control group of 228 non-patients were also asked to fill in the questionnaire. The shorter people slept before they contracted COVID-19, the greater the likelihood of severe symptoms and a longer hospital stay. That there is also a correlation between sleeping badly and an ICU stay due to a COVID-19 infection is also apparent from another very recent study. Sleeping is not only essential to repair the damage caused by viruses, but it also helps your body repair wounds. This is apparent from a study in 2018, in which researchers inflicted (painless) small blisters on the skin of test persons. They were then divided into two groups. One group slept normally; the other group was only allowed to sleep no more than two hours a night for four days. This lack of sleep had a considerable effect on how fast the wounds healed. The wounds of the persons who slept well healed in four days; the wounds of the night owls took a day longer to heal. In short, sleeping is essential for the self-healing ability of your body.’

Sleep gives your immune system a bonus boost ‘Sleep strengthens your immune system directly and indirectly. Sleeping well helps, for example, to maintain a healthy blood sugar level and a healthy weight, which in turn are important for a strong immune system. Moreover, as a result of a lack of sleep you are more likely to become overweight and have too high blood sugar levels, and that increases the risk of all sorts of diseases, for instance, obesity, diabetes and sleep apnea, a disorder that makes sleeping even more difficult. It is exactly the people who suffer from these disorders who appear to have a higher likelihood of contracting a virus infection such as COVID-19 and becoming seriously ill from this. Fortunately, the opposite also applies, and you can prevent this downward spiral from occurring by sleeping well. In this manner, you can give your immune system an extra positive boost! Page 7


Interview

Leaving board members Arthur Kurvers is working as a neurologist-somnologist at the Medical Center Haaglanden in The Hague. He has been secretary in the NSWO board since almost seven years.

been a golden move. There is a lot of energy to organize things. These young colleagues can develop and grow within the association to participation in other committees.”

How do you look back on your time in the NSWO board?

What would you have the NSWO keep in mind?

Arthur

“I see quite a change in how I started and what my position is now. At first I was mostly a minutes secretary, answering phone calls and mainly operating as an intermediary for the chairman. The last years I have been the longest acting board member. Therefore, my position developed into being the continuous factor holding the collective memory. For me it went hand-in-hand with my professional development as a fresh starting neurologist. I was actually finishing my residency when I started in the NSWO board. It has been a nice time!”

What are the changes you have seen in the association during your board membership? “At the start there were more clinician members than now, which was also visible in how the board was assembled. In 2015-2016 there was a discussion the R of research needed to have a prominent place in the association. The Dutch Sleep Medicine Association (Slaapgeneeskunde Vereniging Nederland; SVNL) was founded and attracted many somnologists. This has been a big change for the NSWO. I am glad we have developed a pleasant collaboration with the SVNL, for example resulting in our two-yearly national sleep congress and free participation of SVNL members in our spring and fall meetings. This is a huge success. For me, the NSWO is a comprehensive association connecting the research with the clinical field. It is not only interesting for sleep researchers and sleep clinicians to be a member, but also for the sleep technicians. The founding of the Young Scientist committee has

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“I feel it is important to keep the conversation going with our constituency. Actually, the COVID-19 pandemic made this easier. We have developed new ways of blended care, and hybrid meetings are now familiar for everybody. There are more members present at association meetings than ever. If you ask me as a clinician, I would prefer to keep a clinical somnologist in the board. At least one of them, to clearly and visibly keep the connection with the clinical field. And, not unimportant, I think sponsors like this combination of research and clinicians. It might help to keep the finances healthy.”

When a new secretary is in place, will you stay active in the NSWO? “Probably I will first take a short break. After that I hope to become a member of one of the committees within the association. I will keep advocating that we must keep close connections with the clinical field and maintain our warm relationship with the SVNL.”


Esmée Verwijk is working as a clinical neuropsychologist at the university hospital (AUMC) in our capital and holds a position as assistant professor clinical neuropsychology at the University of Amsterdam. She has been treasurer of the NSWO board since October 2018.

“I was asked by Ysbrand. He told me I might be interested based on my research work. Ysbrand and I had collaborated earlier on several articles. I did check at first how much time it would cost me (laughs), but it seemed doable. What attracted me was the possibility to contribute to further integration of science and clinical work. I did not know the association so well before I started my board membership. It took me roughly a year to get to know the NSWO and the routes within the association and than the COVID-19 pandemic started. Therefore, it was a strange time. I have not been able to see many members in real life! I have missed this, because it would have given me a chance to integrate further. I feel I have been an online treasurer in the background, who tried to innovate administrative processes around memberships and payments. I do feel we were able to modernize this in the last years, but it still needs a maintenance battle. Currently, I am doing the tasks at-interim and the position is open.”

What are you focusing on in your day-to-day work? “I am working in an outpatient neurology clinic. Sleep is never the primary referral reason. But, it is something I always thoroughly focus on when I see my patients. I still observe that this subject is often neglected, which is a great pity. In our multidisciplinary meetings I am always the person bringing up sleep as a factor in the diagnostic and treatment plan of the patient. In addition to being a clinician, research is a big and growing part of my work. The connection between clinical work and research is source of inspiration for me. Most of my research focuses on electroconvulsive therapy (ECT). With regard to sleep, it started for me with a psychiatric patient who spontaneously recovered after sleep deprivation. This caught my interest for chronobiology. In all of my projects I incorporate sleep. For example, is sleep a mediating factor for ECT outcome? Last year I participated in a project on long-term outcomes of COVID-19. There I was also able to prevent the idea that sleep was covered by just adding a question on tiredness.”

What are thoughts you want to leave for the association? “This is a hard question because undoubtedly I have missed things. I see a very enthusiastic group of people. There is a lot of

Esmée

How do you look back on your board membership at the NSWO?

young blood and innovative ideas. I do feel that as a research association we can position ourselves even further. I feel it is important to bridge the gap to the clinic, because I see increasing interest in sleep in all fields of medicine. Clinicians ought to have a hunger for research information in order to maintain the highest standards in performing their professions. There have been limitations due to the COVID-19 pandemic, but now comes the time we can see and inspire each other in real life again. I am looking forward to that.”

Will you stay active within the NSWO? “I won’t be active in the board anymore or one of the committees, but for sure I will keep my NSWO membership. In my day-to-day work I will always give sleep a prominent place both in research as in the clinic. Ysbrand and I are also active to incorporate sleep education in psychology and medicine bachelor teaching program in Amsterdam. We want to position sleep as a mandatory topic. I will give my best to achieve this. And, I am always available to think along study designs with regard to sleep.” Page 9


Dutch doctoral dissertations published and defended in 2021

My daily moves

Hora Est!

Determinants and measurement of movement behaviors from the child-perspective

Lisan M. Hidding

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My daily moves

Determinants and measurement of movement behaviors from the child-perspective Lisan M. Hidding

Uitnodiging Voor het bijwonen van de verdediging van mijn proefschrift

My daily moves Determinants and measurement of movement behaviors from the child-perspective Lisan M. Hidding Vrijdag 29 oktober 2021 om 13:45 Aula van de Vrije Universiteit Aan de Boelelaan 1105 te Amsterdam Na afloop ben je van harte uitgenodigd op de receptie Paranimfen Anna Pleijsier Lotte de Boer Volg live via het YouTube kanaal VU Beadle’s Office


See page 12

See page 16 GENETIC AND METABOLIC STUDIES OF AGING, DEPRESSION AND SLEEP IN THE GENERAL POPULATION

GENETIC AND METABOLIC STUDIES

VIDEO RESPIRATION MONITORING

OF AGING, DEPRESSION AND SLEEP IN THE GENERAL POPULATION

TOWARDS REMOTE APNEA DETECTION IN THE CLINIC

A.VAN DER SPEK

Ilde Lorato ASHLEY VAN DER SPEK

See page 14

See page 18 Do underground workspaces impact workers health? A cohort study examining sleep quality, psychological distress and health-related quality of life Gerard Dunleavy

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HORA EST!

Studies on sleep patterns and sleep homeostasis in birds An ecological approach P h D T H E S I S S J O E R D VA N H A S S E LT S U C C E S S F UL LY D E F E ND E D O N 0 5 N O V E MB E R 2 0 2 1 AT T HE R I JKS UNIV E R SI T E I T GR ONINGE N

Sleep is a complex phenomenon that consists of two completely different and alternating states, slow-wave sleep (SWS) and rapid-eye-movement sleep (REM sleep). Each of these two states is thought to play an important role in supporting brain and bodily functions. Yet, how exactly sleep fulfills these functions is a topic of ongoing research and debate. Most of what is known about sleep is derived from studies that were done in mammals under strictly controlled laboratory conditions. However, sleep is not restricted to mammals but is thought to be present in all living animals. Moreover, studies in a laboratory setting may not provide a complete picture of the regulatory processes and functions of sleep under natural conditions. For that reason, I measured sleep in three bird species under both laboratory conditions and semi-natural conditions: the European jackdaw (Coloeus monedula), the European starling (Sturnus vulgaris) and the barnacle goose (Branta leucopsis). The results provide evidence for homeostatic regulation of SWS in birds similar to what has been reported for mammals, but also produced unexpected findings. For example, the geese only showed a rebound of SWS after brief sleep deprivation in summer but not in winter. Also, both geese and starlings displayed strong seasonal variation in the overall amount of sleep. The starling in particular slept 5h per day less in summer than they did in winter. Moreover, both geese and starlings slept about 2h less during full moon nights than new moon nights. Another intriguing finding was the strong variation in REM sleep between the 3 species, which ranged from hardly any REM sleep in starlings to a much higher, mammalian-like amount of REM sleep in jackdaws. Such findings are difficult to reconcile with current theories in the function of REM sleep that are largely based on studies in mammals. Together, these findings in birds indicate that sleep is highly sensitive to environmental factors and suggest a great deal of flexibility in the regulation of sleep under natural conditions.

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Q&A Sjoerd What is the core message of your thesis? We have shown that sleep under more natural conditions shows an enormous amount of flexibility. This flexibility ranges from starlings that sleep 5 hours more in winter then in summer to barnacle geese that do not recover from sleep deprivation in winter while they do recover to sleep deprivation in summer. Moreover, we found among three bird species a large variation in the presence of REM sleep, from almost no REM sleep in starlings to mammalian-like numbers in Jackdaws. These data fuel the discussion on the function of REM sleep in birds and whether it is homologues to mammalian REM sleep.

What have been your steps after finishing your dissertation? Currently, I am working in the same lab as during my PhD. Now as a postdoc, I want to understand the mechanisms behind the flexibility of sleep across the seasons. We are currently trying to understand whether the seasonal differences in sleep architecture is an endogenously regulated process, or simply a direct response to changing natural photoperiod. We also want to get a better understanding of the function and regulation of REM sleep in birds by selectively depriving them of REM sleep.

What would you recommend to starting researchers in the sleep field? Picture of me in Tobseda, a remote, desolate village in the Russian tundra, together with my first operated barnacle goose. Actually, this is the one that flew back all the way to the Netherlands, the only one with a working GPS on his back.

I would recommend starting sleep researchers to take into account the ecology of sleep. What I have learned over the past years is that natural sleep is much more flexible than sleep in a laboratory. This has not only been reported for animals, also studies in pre-industrialized humans showed seasonal variation in sleep time. For truly understanding the evolution and function of sleep, we occasionally need to go outside the lab.

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HORA EST!

Sleep in children with acute lymphoblastic leukemia An opportunity to improve well-being P h D T H E S I S L I N D S AY S T E U R S U C C E S S F UL LY D E F E ND E D O N 1 5 J A NU A R Y 2 0 2 1 AT T HE V R I JE UNIV E R SI T E I T A MS T E R DA M

Acute Lymphoblastic Leukemia (ALL) is the most common type of childhood cancer. In the Netherlands, approximately 130 children are newly diagnosed with ALL each year. Survival rates have reached over 90%, due to the establishment of long and intensive chemotherapy regimens and enhanced supportive care. However, both during and after treatment, patients and their families are at risk for impaired quality of life and other adverse effects, amongst which are sleep disturbances. Sleep disturbances are associated with many adverse physical and psychosocial health

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outcomes, and negative daytime consequences. Children with ALL are vulnerable to sleep problems, presumably due to treatmentrelated toxicities (such as pain, nausea, and infectious diseases), environmental noises during hospitalization, psychological factors (such as, anxiety, distress, and fatigue), and social factors (such as altered parenting strategies, impaired parental psychosocial functioning, and changed social patterns). Knowledge of child sleep and sleep-wake rhythms during and shortly after ALL treatment was limited. Therefore, the main goal of this thesis was to determine the prevalence, predictors, and development of sleep and sleep-wake rhythm disturbances in children with ALL during and after treatment. We found that the prevalence of sleep disturbances was twice as high in children with ALL (38%) compared to healthy children (17%), and that sleep disturbances persisted up to 3 years after diagnosis. Parental sleep, parenting problems, and bedroom sharing were potentially modifiable perpetuating factors that were associated with child sleep. Furthermore, sleep-wake rhythms were disrupted and physical activity levels were reduced during treatment for ALL, which was associated with increased levels of cancer-related fatigue. Based on the results we could conclude that, in order to prevent sleep disturbances in children with ALL, it is important to pay attention to both child and parental sleep and to support parents in coping with their child’s sleep behavior. Implementation of a stepped care intervention could provide opportunities for the prevention and treatment of sleep (-wake rhythm) disturbances in children with ALL. This intervention should include psychoeducation in the first steps and evaluation and treatment of sleep disturbances by a health care professional for patients with persistent sleep problems. Such an intervention aimed at preventing sleep(-wake rhythm) disturbances could be a gateway to improve well-being and thereby increase quality of survival in children with ALL.


Q&A Lindsay What is the core message of your thesis? The prevalence of sleep problems is high in children with ALL and persist up to three years after diagnosis. Sleep problems in children with ALL are associated with parental sleep, parenting problems, and bedroom sharing. In order to prevent sleep disturbances in children with ALL, it is important to pay attention to both child and parental sleep and to support parents in coping with their child’s sleep behavior.

What was the most memorable moment during your PhD? Hard to choose one! There have been many moments of which I hold good memories; the inclusion of the first participant in the study, the last inclusion, wrapping up the data collection, my first publication, presentations at (international) conferences, submitting my final thesis and of course the defense itself.

What have been your steps after finishing your dissertation? While finalizing my dissertation I started with my training to become a pediatrician (AIOS) in the Emma Children’s Hospital, Amsterdam UMC. Furthermore, I am still involved in the com-pletion of some projects from my PhD-research, such as a study on fatigue and quality of life in children with leukemia. Finally, I am also involved in a study currently running in the Emma Children’s Hospital, Amsterdam UMC, about sleep during hospitalization in children with an acute or chronic condition.

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HORA EST!

The autoimmune hypothesis of narcolepsy and its unexplored clinical features PhD THESIS MINK SCHINKELSHOEK S U C C E S S F UL LY D E F E ND E D O N 1 1 N O V E MB E R 2 0 2 1 AT L E IDE N UNIV E R SI T Y

The autoimmune hypothesis of narcolepsy is that antigens from outside the body trigger an immune response in people susceptible for developing narcolepsy type 1 that leads to an autoimmune attack on the hypocretin-producing neurons in the hypothalamus. The mechanisms involved in the autoimmune hypothesis of narcolepsy are investigated in my thesis. The role of HLA, auto- and cross-reactive T cells is explored and immune cell populations of interest are identified by a new technique, called mass cytometry. The studies in my thesis underline the hypothesis that auto-immunity is highly likely to be involved in the pathogenesis of narcolepsy type 1, even though direct evidence of an auto-immune response could not be demonstrated. Several narcolepsy-specific immune cell populations identified in the thesis could be further investigated in functional testing to assess their role in the auto-immune response leading to narcolepsy type 1. The second part of the thesis assesses unexplored clinical features of narcolepsy, such as weight gain and sleep state misperception. Narcolepsy type 1 is mostly characterized by a pentad of core symptoms: excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, sleep paralysis and disturbed nocturnal sleep. However, many patients experience at least as much interference in their daily life because of more unexplored symptoms of narcolepsy type 1. The study results show that sodium oxybate decreases weight in narcolepsy type 1, especially in women with a high BMI when sodium oxybate use is initiated whereas modafinil does not have this effect. Additionally, sleep state misperception during the daytime naps of the multiple sleep latency test is very common not only in narcolepsy type 1, but also in other hypersomnolence disorders. This should be considered in clinical practice when asking patients about daytime napping.

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Q&A Mink What is the core message of your thesis? Narcolepsy type 1 is highly likely to be caused by an auto-immune response that involves autoreactive T cells in vulnerable individuals that encounter an external trigger, such as an immune response to a micro-organism. Additionally, more emphasis should be put on symptoms of narcolepsy type 1 that are not in the core symptom pentad, since they have a profound impact on everyday functioning of people with narcolepsy type 1.

What have been your steps after finishing your dissertation? Right now, I am doing my training to become a neurologist (AIOS). In the meantime, I am still involved in research project in the research group led by Gert Jan Lammers and Rolf Fronczek in which I completed my PhD.

How do you use your knowledge from your sleep PhD-studies in your current field? During my clinical rounds, I focus a lot more on the role of sleep in the recovery process of patients that are admitted due to other diseases. Additionally, the experience of completing a PhD is helping me a lot every day when encountering and tackling unexpected setbacks.

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HORA EST!

Tired of being tired Fatigue and sleep following traumatic brain injury PhD THESIS JESSICA BRUIJEL

S U C C E S S F UL LY D E F E ND E D O N 0 1 D E C E MB E R 2 0 2 1 AT M A AS T R IC H T UNIV E R SI T Y

fatigue following TBI were explored. In addition, the relationship between sleep disturbances and physical activity following TBI was examined.

In her PhD thesis, Jessica examined sleep and fatigue in people with traumatic brain injury (TBI). TBI refers to a disruption of the function of the brain caused by an external force such as a fall or traffic accident. Sleep disturbances and fatigue are common following TBI and negatively impact social, physical, cognitive, and general functioning. Despite this impact, the experience of fatigue and sleep disturbances following TBI is still poorly understood. In this thesis, novel ways to assess fatigue were examined and the behavioural and neurobiological underpinnings of Page 18

In line with previous research, participants with TBI reported high levels of fatigue and poor sleep quality. These high levels of fatigue could not be explained by higher vulnerability to the fatigue-inducing effects of mental effort or a slower recovery from task-induced fatigue. Jessica therefore concluded in her thesis that fatigue following TBI might be better explained by the complex demands of everyday life such as external (environment) and internal (emotions) factors. When exploring the neurobiological underpinnings, altered striatal connectivity might represent a neural correlate of fatigue and could thus be an underlying mechanism of fatigue following TBI. Due to the multi-dimensional nature of fatigue, assessment of fatigue might best include both subjective and objective measurements. These objective measures might be specifically useful to assess changes in fatigue over time or the effect of interventions aimed at reducing fatigue. Sleep problems following TBI were not associated with decreased physical activity. However, nightly variation in sleep might affect next-day physical activity, suggesting that improving sleep quality might be relevant to support a physically active lifestyle in people with TBI. At the moment, Jessica is still working on an ongoing longitudinal study examining the course of sleep and fatigue within a biopsychosocial model, this study will add to our understanding of fatigue and sleep following TBI.


Q&A Jessica What is the core message of your thesis? Sleep problems and fatigue are very often present in people with TBI. Altered striatal connectivity might present a neuronal correlate of fatigue following TBI and could be further explored to possibly assist in the diagnosis and treatment of fatigue. Nightly variation in sleep might affect next-day physical activity, suggesting that improving sleep quality might be relevant to support a physically active lifestyle in people with TBI. Future studies might benefit from using a biopsychosocial model to explore fatigue and sleep disturbances following brain injury.

What have been your steps after finishing your dissertation? After finishing my PhD in December 2021, I have started a post-doc position at the same department (Neuropsychology and Psychopharmacology, Maastricht University). I am very excited to further develop and continue with projects examining sleep and fatigue after brain injury. In addition, I am now more involved in teaching at the University.

What would you recommend to starting researchers in the sleep field? Do not underestimate the importance of collaboration. Research is not done all by yourself on a little island. In addition, in my experience, everything often takes longer than you expect.

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Dutch year in review 2021 SLEEP MECHANISMS

Peer-reviewed publications on sleep/wake-research in The Netherlands

The biology of sleep Sleep is a widespread phenomenon that appears to have developed very early in evolution. Yet, it still feels amazing that an octopus, belonging to the group of mollusks that separated from our own evolutionary line some 600 million year ago, independently from us developed complex sleep, with two alternating states, one of which has some resemblance with our REM sleep. The octopus has a highly developed nervous system and an impressive cognitive capacity. Perhaps such findings suggest that the evolution of complex and multistage sleep has paralleled the evolution of complex brains and behavior. And maybe studying and comparing different groups of animals can therefore teach us about the possible functions of sleep and different sleep stages. While these possible functions of sleep remain a topic of debate and discussion, one theory that certainly gained traction in recent years is the idea that sleep serves to flush our brain and clean it from waste products that accumulate during waking. This process is thought to be facilitated by the brain’s glymphatic system, which primarily during sleep facilitates a flow of cerebrospinal fluid into and through the brain tissue, taking up the waste products on its way. But surely, as many of the papers below suggest, there is more to sleep than just flushing out the dirt. For example, both slow-wave sleep and REM sleep are thought to play a role in regulating neuronal plasticity, which is particularly important during early development of the brain. But also later in adult life, sleep-mediated plasticity may serve to facilitate the formation of new memories. While we generally sleep with our whole brain, the pressure for it may vary across different regions, when the need for sleep has built up in some part of the brain more rapidly than in others. In fact, it has been proposed that high local sleep pressure may be a cause of mind wandering, when certain brain areas depleted of resources go off-line, leaving the rest of the brain in a state of limbo. Importantly, while sleep is strongly affected by how long we are awake, by the things we do and the information that we process, sleep also has a strong genetic component. Such genetic influences should be taken into consideration when trying to understand the mechanisms underlying sleep patterns and individual differences in sleep. PE TER MEERLO, PhD - UNIVERSIT Y OF GRONINGEN, GRONINGEN

SLEEP BIOLOGY Akkermann M, Akkaya UC, Demirel C, Pflüger D, Dresler M. Sound sleep: lullabies as a test case for the neurobiological effects of music. Behavioral and Brain Sciences 2021.

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Bódizs R, Horváth CG, Szalárdy O, Ujma PP, Simor P, Gombos F, Kovács I, Genzel L, Dresler M. Sleep-spindle frequency: Overnight dynamics, afternoon nap effects, and possible circadian modulation. J Sleep Res. 2021.


Bódizs R, Szalárdy O, Horváth C, Ujma PP, Gombos F, Simor P, Pótári A, Zeising M, Steiger A, Dresler M. A set of composite, non-redundant EEG measures of NREM sleep based on the power law scaling of the Fourier spectrum. Sci Rep. 2021. Jubera-Garcia E, Gevers W, Van Opstal F. Local build-up of sleep pressure could trigger mind wandering: Evidence from sleep, circadian and mind wandering research. Biochem Pharmacol. 2021. Khachatryan SG, Korostovtseva L, Deleanu O, Gnidovec-Stražišar B, Young P, Engstrøm M, van der Werf YD; Assembly of National Sleep Societies. The Assembly of National Sleep Societies (ANSS-ESRS) moves "Beyond Boundaries": A project announcement. J Sleep Res. 2021. Knoop MS, de Groot ER, Dudink J. Current ideas about the roles of rapid eye movement and non-rapid eye movement sleep in brain development. Acta Paediatr. 2021. Kocevska D, Barclay NL, Bramer WM, Gehrman PR, Van Someren EJW. Heritability of sleep duration and quality: A systematic review and meta-analysis. Sleep Med Rev. 2021. Overeem S, van Litsenburg RRL, Reading PJ. Sleep disorders and the hypothalamus. Handb Clin Neurol. 2021. Rakusa M, Sieminski M, Rakusa S, Falup-Pecurariu C, Fronczek R, Hidalgo H, Muntean ML, Pijpers A, Cochen De Cock V, Pizza F, Schmidt M, Schreier DR, Baldin E, Bassetti CLA, Kallweit U. Awakening to sleep disorders in Europe: Survey on education, knowledge and treatment competence of European residents and neurologists. Eur J Neurol. 2021. Ramaswamy SM, Weerink MAS, Struys MMRF, Nagaraj SB. Dexmedetomidine-induced deep sedation mimics non-rapid eye movement stage 3 sleep: large-scale validation using machine learning. Sleep. 2021.

Sakalauskaité-Juodeikiené E, Eling P. Hildegard of Bingen (c. 1098-1179) on sleep and dreams in her Causae et curae and Physica: a historical perspective. Sleep Med. 2021. Samanta A, van Rongen LS, Rossato JI, Jacobse J, Schoenfeld R, Genzel L. Sleep Leads to BrainWide Neural Changes Independent of Allocentric and Egocentric Spatial Training in Humans and Rats. Cereb Cortex. 2021. Sysoev IV, van Luijtelaar G, Lüttjohann A. Thalamo-Cortical and Thalamo-Thalamic Coupling During Sleep and Wakefulness in Rats. Brain Connect. 2021. Brain Connect. 2021. Tahmasian M, Aleman A, Andreassen OA, Arab Z, Baillet M, Benedetti F, Bresser T, Bright J, Chee MWL, Chylinski D, Cheng W, Deantoni M, Dresler M, Eickhoff SB, Eickhoff CR, Elvsåshagen T, Feng J, Foster-Dingley JC, Ganjgahi H, Grabe HJ, Groenewold NA, Ho TC, Bong Hong S, Houenou J, Irungu B, Jahanshad N, Khazaie H, Kim H, Koshmanova E, Kocevska D, Kochunov P, Lakbila-Kamal O, Leerssen J, Li M, Luik AI, Muto V, Narbutas J, Nilsonne G, O'Callaghan VS, Olsen A, Osorio RS, Poletti S, Poudel G, Reesen JE, Reneman L, Reyt M, Riemann D, Rosenzweig I, Rostampour M, Saberi A, Schiel J, Schmidt C, Schrantee A, Sciberras E, Silk TJ, Sim K, Smevik H, Soares JC, Spiegelhalder K, Stein DJ, Talwar P, Tamm S, Teresi GL, Valk SL, Van Someren E, Vandewalle G, Van Egroo M, Völzke H, Walter M, Wassing R, Weber FD, Weihs A, Westlye LT, Wright MJ, Wu MJ, Zak N, Zarei M. ENIGMA-Sleep: Challenges, opportunities, and the road map. J Sleep Res. 2021. van Hasselt SJ, Verhulst S, Piersma T, Rattenborg NC, Meerlo P. A comparison of continuous and intermittent EEG recordings in geese: How much data are needed to reliably estimate sleep-wake patterns? J Sleep Res. 2021.

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SLEEP & COGNITION

SLEEP IN SPECIAL CIRCUMSTANCES

Aleman-Zapata A, van der Meij J, Genzel L. Disrupting ripples: Methods, results, and caveats in closed-loop approaches in rodents. J Sleep Res. 2021.

Huss A, Özdemir E, Schaap K, Kromhout H. Occupational exposure to MRI-related magnetic stray fields and sleep quality among MRI Technicians – A cross-sectional study in the Netherlands. Int J Hyg Environ Health. 2021.

Bolsius YG, Zurbriggen MD, Kim JK, Kas MJ, Meerlo P, Aton SJ, Havekes R. The role of clock genes in sleep, stress and memory. Biochem Pharmacol. 2021. Dias I, Levers MR, Lamberti M, Hassink GC, van Wezel R, le Feber J. Consolidation of memory traces in cultured cortical networks requires low cholinergic tone, synchronized activity and high network excitability. J Neural Eng. 2021. Huber R, Ghosh A. Large cognitive fluctuations surrounding sleep in daily living. iScience. 2021. Leenaars CHC, Van der Mierden S, Joosten RNJMA, Van der Weide MA, Schirris M, Dematteis M, Meijboom FLB, Feenstra MGP, Bleich A. Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats. Clocks Sleep. 2021. Plamberger CP, Van Wijk HE, Kerschbaum H, Pletzer BA, Gruber G, Oberascher K, Dresler M, Hahn MA, Hoedlmoser K. Impact of menstrual cycle phase and oral contraceptives on sleep and overnight memory consolidation. J Sleep Res. 2021. Raven F, Bolsius YG, van Renssen LV, Meijer EL, van der Zee EA, Meerlo P, Havekes R. Elucidating the role of protein synthesis in hippocampusdependent memory consolidation across the day. and night. Eur J Neurosci. 2021.

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Koller DP, Kasanin V, Flynn-Evans EE, Sullivan JP, Dijk DJ, Czeisler CA, Barger LK. Altered sleep spindles and slow waves during space shuttle missions. NPJ Microgravity. 2021. Nieuwenhuys A, Dora J, Knufinke-Meyfroyt M, Beckers D, Rietjens G, Helmhout P. "20,000 leagues under the sea": Sleep, cognitive performance, and self-reported recovery status during a 67-day military submarine mission. Appl Ergon. 2021. van Ombergen A, Rossiter A, Ngo-Anh TJ. 'White Mars' - nearly two decades of biomedical research at the Antarctic Concordia station. Exp Physiol. 2021.


THE CIRCADIAN CLOCK

Enlightening Dutch clock research Sleep regulation is highly dependent on circadian clock functioning. Viewing the publications from the field of circadian rhythms, it is striking that a wide range of sub-themes is covered by Dutch research groups: topics range from fundamental research on clock genes and SCN network structures, to field studies on sleep patterns in shift workers. Interestingly, new promising techniques were applied, for instance the idea of ‘chronophotopharmacology’. With the use of a photoswitchable derivate that inhibits the enzyme casein kinase I (CKI, essential in the timekeeping molecular loop), quantitative and light-inducible control over the CKI activity was achieved in cultured cells, thereby facilitating a temporary modulation of the circadian period length by light (Kolarski et al). Several publications reported on behavioural or physiological responses to light exposure, either to unravel the underlying mechanisms of entrainment, or to study how to optimize the light (and dark) conditions in specific populations, such as hospitalized people, athletes, elderly, people with mood disorders and shift workers. With respect to the mechanisms, the contribution of classical photoreceptors to the photoentrainment pathway, in addition to melanopsin signaling, is still intriguing. The finding that both cone subtypes in mice contribute, each in a different way (Van Diepen et al.), implicates a broad spectral sensitivity range of the circadian system. There is also increasing attention for entraining signals other than light. For instance, behavioural arousal stimuli may act as a potent Zeitgeber; major question is to look for the circadian windows of sensitivity to behavioural arousal (Jha et al.). Also the timing of food intake, so-called ‘chrononutrition’, is a fast emerging field. It was subject of the keynote lecture at ‘SLAAP2021’ by Prof. Dries Kalsbeek and increasing knowledge may lead to many applications, such as the time-restricted feeding protocols on the intensive care units (Veldscholte et al.). The timing of light, exercise and food intake is highly relevant to incorporate into lifestyle medicine, to prevent or reduce negative health outcomes, especially in groups at risk such as shift workers. So far, just a glimpse of the extensive research from Dutch ground, with much more to come in the upcoming years, also from the multiproject ‘BioClock Consortium’ that started last year. Read below and get enlightened! F L O O R V A N O O S T E R H O U T , P h D , P H Y S I C I A N A S S I S T A N T S O M N O L O G Y, S L E E P / W A K E C E N T E R S E I N

CIRCADIAN SYSTEM Caliandro R, Streng AA, van Kerkhof LWM, van der Horst GTJ, Chaves I. Social Jetlag and Related Risks for Human Health: A Timely Review. Nutrients. 2021. Coomans C, Saaltink DJ, Deboer T, Tersteeg M, Lanooij S, Schneider AF, Mulder A, van Minnen J, Jost C, Koster AJ, Vreugdenhil E. Doublecortinlike expressing astrocytes of the suprachiasmatic nucleus are implicated in the biosynthesis of vasopressin and influences circadian rhythms. Glia. 2021.

Flanagan A, Bechtold DA, Pot GK, Johnston JD. Chrono-nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns. J Neurochem. 2021. Gu C, Li J, Zhou J, Yang H, Rohling J. Network Structure of the Master Clock Is Important for Its Primary Function. Front Physiol. 2021. Jha PK, Bouâouda H, Kalsbeek A, Challet E. Distinct feedback actions of behavioural arousal to the master circadian clock in nocturnal and diurnal mammals. Neurosci Biobehav Rev. 2021.

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Kolarski D, Miller S, Oshima T, Nagai Y, Aoki Y, Kobauri P, Srivastava A, Sugiyama A, Amaike K, Sato A, Tama F, Szymanski W, Feringa BL, Itami K, Hirota T. Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J Am Chem Soc. 2021. Kolarski D, Miró-Vinyals C, Sugiyama A, Srivastava A, Ono D, Nagai Y, Iida M, Itami K, Tama F, Szymanski W, Hirota T, Feringa BL. Reversible modulation of circadian time with chronophotopharmacology. Nat Commun. 2021. Kolarski D, Sugiyama A, Rodat T, Schulte A, Peifer C, Itami K, Hirota T, Feringa BL, Szymanski W. Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKI∂ activity and circadian rhythms. Org Biomol Chem. 2021. Ota SM, Kong X, Hut R, Suchecki D, Meerlo P. The impact of stress and stress hormones on endogenous clocks and circadian rhythms. Front Neuroendocrinol. 2021. Saad L, Kalsbeek A, Zwiller J, Anglard P. Rhythmic Regulation of DNA Methylation Factors and Core-Clock Genes in Brain Structures Activated by Cocaine or Sucrose: Potential Role of Chromatin Remodeling. Genes (Basel). 2021. Saad L, Zwiller J, Kalsbeek A, Anglard P. Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction. Genes (Basel). 2021. Veldscholte K, Cramer ABG, Joosten KFM, Verbruggen SCAT. Intermittent fasting in paediatric critical illness: The properties and potential beneficial effects of an overnight fast in the PICU. Clin Nutr. 2021.

LIGHT EXPOSURE AND PHOTORECEPTION Böhmer MN, Hamers PCM, Bindels PJE, Oppewal A, van Someren EJW, Festen DAM. Are we still in the dark? A systematic review on personal daily light exposure, sleep-wake rhythm, and mood in healthy adults from the general population. Sleep Health. 2021. Böhmer MN, Valstar MJ, Aarts MPJ, Bindels PJE, Oppewal A, van Someren EJW, Festen DAM. Shedding light on light exposure in elderly with intellectual disabilities. J Intellect Disabil Res. 2021. Derks L, Houterman S, Geuzebroek GSC, van der Harst P, Smits PC; PCI Registration Committee of the Netherlands Heart Registration. Daylight saving time does not seem to be associated with number of percutaneous coronary interventions for acute myocardial infarction in the Netherlands. Neth Heart J. 2021. Gegnaw ST, Sandu C, Mendoza J, Bergen AA, Felder-Schmittbuhl MP. Dark-adapted light response in mice is regulated by a circadian clock located in rod photoreceptors. Exp Eye Res. 2021. Goudriaan I, van Boekel LC, Verbiest MEA, van Hoof J, Luijkx KG. Dementia Enlightened?! A Systematic Literature Review of the Influence of Indoor Environmental Light on the Health of Older Persons with Dementia in Long-Term Care Facilities. Clin Interv Aging. 2021. Hazelhoff EM, Dudink J, Meijer JH, Kervezee L. Beginning to See the Light: Lessons Learned From the Development of the Circadian System for Optimizing Light Conditions in the Neonatal Intensive Care Unit. Front Neurosci. 2021. Knufinke M, Nieuwenhuys A, Geurts SAE, Møst EIS, Moen MH, Maase K, Coenen AML, Gordijn MCM, Kompier MAJ. Dim light, sleep tight, and wake up bright - Sleep optimization in athletes by means of light regulation. Eur J Sport Sci. 2021.

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Milicevic N, Ait-Hmyed Hakkari O, Bagchi U, Sandu C, Jongejan A, Moerland PD, Ten Brink JB, Hicks D, Bergen AA, Felder-Schmittbuhl MP. Core circadian clock genes Per1 and Per2 regulate the rhythm in photoreceptor outer segment phagocytosis. FASEB J. 2021.

van Hasselt SJ, Hut RA, Allocca G, Vyssotski AL, Piersma T, Rattenborg NC, Meerlo P. Cloud cover amplifies the sleep-suppressing effect of artificial light at night in geese. Environ Pollut. 2021.

Papatsimpa C, Schlangen LJM, Smolders KCHJ, Linnartz JMG, de Kort YAW. The interindividual variability of sleep timing and circadian phase in humans is influenced by daytime and evening light conditions. Sci Rep. 2021.

van Hasselt SJ, Mekenkamp GJ, Komdeur J, Allocca G, Vyssotski AL, Piersma T, Rattenborg NC, Meerlo P. Seasonal variation in sleep homeostasis in migratory geese: a rebound of NREM sleep following sleep deprivation in summer but not in winter. Sleep. 2021.

Schlangen LJM, Price LLA. The Lighting Environment, Its Metrology, and Non-visual Responses. Front Neurol. 2021. Schulte PFJ, Riemersma-van der Lek RF. Evening chronotype, disordered eating behavior, bipolar disorder, and light therapy. Acta Psychiatr Scand. 2021. van Diepen HC, Schoonderwoerd RA, Ramkisoensing A, Janse JAM, Hattar S, Meijer JH. Distinct contribution of cone photoreceptor subtypes to the mammalian biological clock. Proc Natl Acad Sci U S A. 2021.

SEASONAL RHYTHMS

van Rosmalen L, Hut RA. Food and temperature change photoperiodic responses in two vole species. J Exp Biol. 2021. van Rosmalen L, van Dalum J, Appenroth D, Roodenrijs RTM, de Wit L, Hazlerigg DG, Hut RA. Mechanisms of temperature modulation in mammalian seasonal timing. FASEB J. 2021. Zerbini G, Winnebeck EC, Merrow M. Weekly, seasonal, and chronotype-dependent variation of dim-light melatonin onset. J Pineal Res. 2021.

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SHIFT WORK Carpio Arias TV, Mogrovejo Arias DC, Nicolalde Cifuentes TM, Tapia Veloz EC, De Zeeuw CI, Vinueza Veloz MF. Sleep quality does not mediate the negative effects of chronodisruption on body composition and metabolic syndrome in healthcare workers in Ecuador. Diabetes Metab Syndr. 2021.

during a 2-week-on/2-week-off offshore shift rotation: an observational repeated-measures study. BMC Public Health. 2021. Thomas J, Overeem S, Dresler M, Kessels RPC, Claassen JAHR. Shift-work-related sleep disruption and the risk of decline in cognitive function: The CRUISE Study. J Sleep Res. 2021.

de Rijk MG, van Eekelen APJ, Kaldenberg E, Boesveldt S, Te Woerd W, Holwerda T, Lansink CJM, Feskens EJM, de Vries JHM. The association between eating frequency with alertness and gastrointestinal complaints in nurses during the night shift. J Sleep Res. 2021.

Tummers FHMP, Huizinga CRH, van Pampus MG, Stockmann HBAC, Cohen AF, van der Bogt KEA; Fit to Perform collaborators. Assessment of fitness to perform using a validated self-test in obstetric and gynecological night shifts in the Netherlands. Am J Obstet Gynecol. 2021.

Hagan-Haynes K, Pratt S, Lerman S, Wong I, Baker A, Flower D, Riethmeister V. US research needs related to fatigue, sleep, and working hours among oil and gas extraction workers. Am J Ind Med. 2021.

van de Ven HA, Hulsegge G, Zoomer T, de Korte EM, Burdorf A, Oude Hengel KM. The acute effects of working time patterns on fatigue and sleep quality using daily measurements of 6195 observations among 223 shift workers. Scand J Work Environ Health. 2021.

Hulsegge G, Proper KI, Loef B, Paagman H, Anema JR, van Mechelen W. The mediating role of life-style in the relationship between shift work, obesity and diabetes. Int Arch Occup Environ Health. 2021. Kalsbeek A, Buijs RM. Organization of the neuroendocrine and autonomic hypothalamic paraventricular nucleus. Handb Clin Neurol. 2021. Kervezee L, Gonzales-Aste F, Boudreau P, Boivin DB. The relationship between chronotype and sleep behavior during rotating shift work: a field study. Sleep. 2021. Linz D, Arzt M, Baumert M. Keep your rhythm during rotational night work shifts! Eur Heart J. 2021. Ots P, Riethmeister V, Almansa J, Bültmann U, Brouwer S. The courses of objective physical activity and the association with sleepiness

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SLEEP ACROSS THE LIFESPAN

Sleep across the lifespan: It’s the numbers that count Browsing through the lifespan publications one striking observation is the fast numbers of participants in the studies published this year. If there are not over 1000 participants in the final study, then at least the study starts out with an initial number of over 1000 putative participants. Number one is the twin study of Vermeulen et al., where 12803 twins participated. Does this mean that we are dealing here with over 25000 participants? No, but still 12803 individuals is quite an achievement. Conclusion from that study, among others, is that sleep quality is more important than sleep quantity. All these studies are contrasted by the study from Zuidersma et al., which is using the ‘n-of-1’ approach, where a limited number of older participants is followed, but then over 63 consecutive days. This allows for a temporal association between other symptoms and sleep variables. Finally, there are two reviews from Buijink and Michel, and Panagiotou et al. Both on aging; one focusing on circadian rhythms, the other on sleep. They include model studies in rodents and human data. Reading those should give a good overview of the present state of fundamental research on sleep and circadian rhythms in aging. T O M D E B O E R , P h D – L A B O R A T O R Y F O R N E U R O P H Y S I O L O G Y, D E P A R T M E N T O F C E L L A N D C H E M I C A L B I O L O G Y, LEIDEN UNIVERSIT Y MEDICAL CENTER (LUMC), LEIDEN

PEDIATRIC SLEEP Belmon LS, Komrij NL, Busch V, Oude Geerdink E, Heemskerk DM, de Bruin EJ, Chinapaw MJM, van Stralen MM. Correlates of inadequate sleep health among primary school children. J Sleep Res. 2021. Cabré-Riera A, van Wel L, Liorni I, KoopmanVerhoeff ME, Imaz L, Ibarluzea J, Huss A, Wiart J, Vermeulen R, Joseph W, Capstick M, Vrijheid M, Cardis E, Röösli M, Eeftens M, Thielens A, Tiemeier H, Guxens M. Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in pre-adolescents. Environ Res. 2022. de Goederen R, Pu S, Silos Viu M, Doan D, Overeem S, Serdijn WA, Joosten KFM, Long X, Dudink J. Radar-based sleep stage classification in children undergoing polysomnography: a pilot-study. Sleep Med. 2021. de Groot ER, Knoop MS, van den Hoogen A, Wang X, Long X, Pillen S, Benders M, Dudink J. The value of cardiorespiratory parameters for sleep state classification in preterm infants: A systematic review. Sleep Med Rev. 2021.

Hoppenbrouwer XLR, Rollinson AU, Dunsmuir D, Ansermino JM, Dumont G, Oude Nijewemed'Hollosy W, Veltink P, Garde A. Night to night variability of pulse oximetry features in children at home and at the hospital. Physiol Meas. 2021. Komrij NL, van Stralen MM, Busch V, Inhulsen MMR, Koning M, de Jong E, Renders CM. Predictors of Changes in Sleep Duration in Dutch Primary Schoolchildren: the ChecKid Study. Int J Behav Med. 2021. Mattsson M, Murray DM, Kiely M, McCarthy FP, McCarthy E, Biesma R, Boland F. Eating behaviour, physical activity, TV exposure and sleeping habits in five year olds: a latent class analysis. BMC Pediatr. 2021. Super CM, Blom MJM, Harkness S, Ranade N, Londhe R. Culture and the organization of infant sleep: A study in the Netherlands and the U.S.A. Infant Behav Dev. 2021. Tham EKH, Xu HY, Fu X, Schneider N, Goh DYT, Lek N, Goh RSM, Cai S, Broekman BFP. Variations in longitudinal sleep duration trajectories from infancy to early childhood. Sleep Health. 2021. Page 27


van den Eijnden RJJM, Geurts SM, Ter Bogt TFM, van der Rijst VG, Koning IM. Social Media Use and Adolescents' Sleep: A Longitudinal Study on the Protective Role of Parental Rules Regarding Internet Use before Sleep. Int J Environ Res Public Health. 2021 Feb 2021. van den Heuvel MI, Hect JL, Smarr BL, Qawasmeh T, Kriegsfeld LJ, Barcelona J, Hijazi KE, Thomason ME. Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth. Sci Rep. 2021. van Kooten JAMC, Terwee CB, Luijten MAJ, Steur LMH, Pillen S, Wolters NGJ, Kaspers GJL, van Litsenburg RRL. Psychometric properties of the Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance and Sleep-Related Impairment item banks in adolescents. J Sleep Res. 2021. Visser SSM, van Diemen WJM, Kervezee L, van den Hoogen A, Verschuren O, Pillen S, Benders MJNL, Dudink J. The relationship between preterm birth and sleep in children at school age: A systematic review. Sleep Med Rev. 2021. Witte AM, de Moor MHM, Szepsenwol O, van IJzendoorn MH, Bakermans-Kranenburg MJ, Shai D. Developmental trajectories of infant nighttime awakenings are associated with infant-mother and infant-father attachment security. Infant Behav Dev. 2021. Zhang D, Long X, Xu L, Werth J, Wijshoff R, Aarts RM, Andriessen P. Characterizing cardiorespiratory interaction in preterm infants across sleep states using visibility graph analysis. J Appl Physiol (1985). 2021.

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SLEEP & AGING Buijink MR, Michel S. A multi-level assessment of the bidirectional relationship between aging and the circadian clock. J Neurochem. 2021. de Feijter M, O'Connor MF, Arizmendi BJ, Ikram MA, Luik AI. The longitudinal association of actigraphy-estimated sleep with grief in middle-aged and elderly persons. J Psychiatr Res. 2021. Druiven SJM, Riese H, Kamphuis J, Haarman BCM, Antypa N, Penninx BWJH, Schoevers RA, Meesters Y. Chronotype changes with age; seven-year follow-up from the Netherlands study of depression and anxiety cohort. J Affect Disord. 2021. Lysen TS, Yilmaz P, Dubost F, Ikram MA, de Bruijne M, Vernooij MW, Luik AI. Sleep and perivascular spaces in the middle-aged and elderly population. J Sleep Res. 2021. Mutambudzi M, van Solinge H. Impact of Retirement on Sleep Problems Among Older Workers and Their Partners. Gerontologist. 2021. Panagiotou M, Michel S, Meijer JH, Deboer T. The aging brain: sleep, the circadian clock and exercise. Biochem Pharmacol. 2021.


SLEEP DIAGNOSTICS AND TECHNOLOGY

Advances in sleep monitoring methods Increasingly fast advances in technology keep changing the field of sleep monitoring and diagnostics. It is great to see that Dutch researchers continue to play a role in this field. International collaborations are highly important in this respect, particularly as artificial intelligence (AI) based methods rely on large amounts of high quality and annotated data. In the past year, several research themes emerge from Dutch groups. There were several important contributions on automated sleep scoring based on EEG. Although this is an area where methods have been available for a relatively long time, advances are still being made. Not only to increase performance and reliability, but also to optimize methods in order to apply them on longer term datasets, and to provide ‘interpretability’: how do these automated models come to their conclusions? The latter is crucial to further foster update in clinical settings. Another theme that can be discerned, is to use personal media – most notably smart phones- to provide input for sleep and especially circadian assessments. Druijff-van de Woestijne and colleagues showed the patterns of smartphone keyboard activity, provide a way to assess rest-activity patterns. Massar et al. combined phone-use data with wearables to identify different traits in nocturnal sleep behavior. Finally, several publications reported on new algorithms to use wearable technology for sleep staging. For example, Wulterkens and colleagues leveraged recently obtained clinical datasets combining gold standard polysomnography and wrist-worn photoplethysmography to develop sleep-staging algorithms that reach adequate performance metrics even in sleep-disordered patients. In the coming years, we will need to assess all these new technologies to determine their place not only in basis sleep research, but in clinical diagnostics as well. P R O F. S E B A S T I A A N O V E R E E M , M D , P h D CENTER FOR SLEEP MEDICINE KEMPENHAEGHE & EINDHOVEN UNIVERSIT Y OF TECHNOLOGY

Altini M, Kinnunen H. The Promise of Sleep: A Multi-Sensor Approach for Accurate Sleep Stage Detection Using the Oura Ring. Sensors (Basel). 2021. Alvarez-Estevez D, Rijsman RM. Inter-database validation of a deep learning approach for automatic sleep scoring. PLoS One. 2021. Crnko S, Schutte H, Doevendans PA, Sluijter JPG, van Laake LW. Minimally Invasive Ways of Determining Circadian Rhythms in Humans. Physiology (Bethesda). 2021. Druijff-van de Woestijne GB, McConchie H, de Kort YAW, Licitra G, Zhang C, Overeem S, Smolders KCHJ. Behavioural biometrics: Using smartphone keyboard activity as a proxy for rest-activity patterns. J Sleep Res. 2021. Hendriks MMS, van Lotringen JH, Vos-van der Hulst M, Keijsers NLW. Bed Sensor Technology for Objective Sleep Monitoring Within the Clinical Rehabilitation Setting: Observational Feasibility Study. JMIR Mhealth Uhealth. 2021.

Kruizinga MD, Heide NV, Moll A, Zhuparris A, Yavuz Y, Kam ML, Stuurman FE, Cohen AF, Driessen GJA. Towards remote monitoring in pediatric care and clinical trials - Tolerability, repeatability and reference values of candidate digital endpoints derived from physical activity, heart rate and sleep in healthy children. PLoS One. 2021. Long X, Espina J, Otte RA, Wang W, Aarts RM, Andriessen P. Video-based actigraphy is an effective contact-free method of assessing sleep in preterm infants. Acta Paediatr. 2021. Lorato I, Stuijk S, Meftah M, Kommers D, Andriessen P, van Pul C, de Haan G. Automatic Separation of Respiratory Flow from Motion in Thermal Videos for Infant Apnea Detection. Sensors (Basel). 2021. Massar SAA, Chua XY, Soon CS, Ng ASC, Ong JL, Chee NIYN, Lee TS, Ghosh A, Chee MWL. Trait-like nocturnal sleep behavior identified by combining wearable, phone-use, and self-report data. NPJ Digit Med. 2021. Page 29


Michel S, Nakamura TJ, Meijer JH, Colwell CS. Electrophysiological Approaches to Studying the Suprachiasmatic Nucleus. Methods Mol Biol. 2021. Oppersma E, Ganglberger W, Sun H, Thomas RJ, Westover MB. Algorithm for automatic detection of self-similarity and prediction of residual central respiratory events during continuous positive airway pressure. Sleep. 2021. Pathak S, Lu C, Nagaraj SB, van Putten M, Seifert C. STQS: Interpretable multi-modal SpatialTemporal-seQuential model for automatic Sleep scoring. Artif Intell Med. 2021. Peri E, Xu L, Ciccarelli C, Vandenbussche NL, Xu H, Long X, Overeem S, van Dijk JP, Mischi M. Singular Value Decomposition for Removal of Cardiac Interference from Trunk Electromyogram. Sensors (Basel). 2021. Radha M, Fonseca P, Moreau A, Ross M, Cerny A, Anderer P, Long X, Aarts RM. A deep transfer learning approach for wearable sleep stage classification with photoplethysmography. NPJ Digit Med. 2021. Reus EEM, Visser GH, Cox FME. Determining the Spike-Wave Index Using Automated Detection Software. J Clin Neurophysiol. 2021. Schipper F, van Sloun RJG, Grassi A, Derkx R, Overeem S, Fonseca P. Estimation of respiratory rate and effort from a chest-worn accelerometer using constrained and recursive principal component analysis. Physiol Meas. 2021. Spina G, Casale P, Albert PS, Alison J, GarciaAymerich J, Clarenbach CF, Costello RW, Hernandes NA, Leuppi JD, Mesquita R, Singh SJ, Smeenk FWJM, Tal-Singer R, Wouters EFM, Spruit MA, den Brinker AC. Nighttime features derived from topic models for classification of patients with COPD. Comput Biol Med. 2021. Sundararajan K, Georgievska S, Te Lindert BHW, Gehrman PR, Ramautar J, Mazzotti DR, Sabia S, Weedon MN, van Someren EJW, Ridder L, Wang J, van Hees VT. Sleep classification from Page 30

wrist-worn accelerometer data using random forests. Sci Rep. 2021. van der Wall HEC, Doll RJ, van Westen GJP, Koopmans I, Zuiker RG, Burggraaf J, Cohen AF. Using machine learning techniques to characterize sleep-deprived driving behavior. Traffic Inj Prev. 2021. van Gastel M, Stuijk S, Overeem S, van Dijk JP, van Gilst MM, de Haan G. Camera-based vital signs monitoring during sleep - A proof of concept study. IEEE J Biomed Health Inform 2021. van Kooten JAMC, Jacobse STW, Heymans MW, de Vries R, Kaspers GJL, van Litsenburg RRL. A meta-analysis of accelerometer sleep outcomes in healthy children based on the Sadeh algorithm: the influence of child and device characteristics. Sleep. 2021. van Mierlo P, Hermans L, Arnulf I, Pijpers A, Overeem S, van Gilst M. Validation of the Dutch translation of the Paris Arousal Disorders Severity Scale for NREM parasomnias in a one-year and one-month version. J Clin Sleep Med. 2021. Verdam MGE, van Ballegooijen W, Holtmaat CJM, Knoop H, Lancee J, Oort FJ, Riper H, van Straten A, Verdonck-de Leeuw IM, de Wit M, van der Zweerde T, Sprangers MAG. Re-evaluating randomized clinical trials of psychological interventions: Impact of response shift on the interpretation of trial results. PLoS One. 2021. Wulterkens BM, Fonseca P, Hermans LWA, Ross M, Cerny A, Anderer P, Long X, van Dijk JP, Vandenbussche N, Pillen S, van Gilst MM, Overeem S. It is All-in the Wrist: Wearable Sleep Staging in a Clinical Population versus Reference Polysomnography. Nat Sci Sleep. 2021. Xie J, Aubert X, Long X, van Dijk J, Arsenali B, Fonseca P, Overeem S. Audio-based snore detection using deep neural networks. Comput Methods Programs Biomed. 2021.


INSOMNIA

Insomnia: Synthesizing the evidence It was the year of bringing the evidence together for Dutch research on insomnia. Many meta-analyses and reviews were published on a wide range of topics: from the genetics of insomnia to spectral EEG findings in insomnia, from (digital) CBT to music therapy. Original research studies showed interesting findings tapping into the mechanisms of insomnia and its treatment. For example, Hermans et al. found that people with insomnia have an increased fragmentation of NREM sleep, but not necessarily of REM sleep. Additionally, Blanken et al. showed that behavioral components of CBT particularly affected sleep efficiency, difficulty maintaining sleep and dissatisfaction, while the cognitive components affected daily functioning, difficulty initiating sleep, early morning awakenings and worries about sleep. Lastly, Fitriani et al. demonstrated that the pleasure of engaging with a digital treatment is an important component for behavior intention, emphasizing its’ importance for improving engagement and attrition in treatment. And more interesting work on insomnia interventions is in the making, in the past year an RCT protocol on investigating the application of online guided CBT in youth and two RCT protocols on the combination of CBT for insomnia with amitriptyline were published, so plenty to watch out for in 2022! ANNEMARIE LUIK , P hD, AS SIS TA N T P R OF E S S OR A ND P R INCIPA L IN V E S T IG AT OR OF P S YC HI AT R IC E P IDE MIOL OGIE , ER ASMUSMC, ROT TERDAM

INSOMNIA DISORDER Barclay NL, Kocevska D, Bramer WM, Van Someren EJW, Gehrman P. The heritability of insomnia: A meta-analysis of twin studies. Genes Brain Behav. 2021.

Zhao W, Van Someren EJW, Li C, Chen X, Gui W, Tian Y, Liu Y, Lei X. EEG spectral analysis in insomnia disorder: A systematic review and meta-analysis. Sleep Med Rev. 2021.

Ferini-Strambi L, Auer R, Bjorvatn B, Castronovo V, Franco O, Gabutti L, Galbiati A, Hajak G, Khatami R, Kitajima T, McEvoy D, Nissen C, Perlis M, Pevernagie DA, Randerath W, Riemann D, Rizzo G, Van Someren E, Vgontzas A, Barazzoni F, Bassetti C; European Sleep Foundation. Insomnia disorder: clinical and research challenges for the 21st century. Eur J Neurol. 2021. Hermans LWA, Regis M, Fonseca P, Hoondert B, Leufkens TRM, Overeem S, van Gilst MM. Sleep-Wake Survival Dynamics in People with Insomnia. Nat Sci Sleep. 2021. van den Broek N, Festen D, Tan F, Overeem S, Pillen S. What is in a name? Definitions of insomnia in people with intellectual disabilities. J Appl Res Intellect Disabil. 2021. van Someren EJW. Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev. 2021. Page 31


INSOMNIA INTERVENTIONS Peersmann SHM, van Straten A, Kaspers GJL, Thano A, van den Bergh E, Grootenhuis MA, van Litsenburg RRL. Does the guided online cognitive behavioral therapy for insomnia "i-Sleep youth" improve sleep of adolescents and young adults with insomnia after childhood cancer? (MICADO-study): study protocol of a randomized controlled trial. Trials. 2021. Albakri U, Drotos E, Meertens R. Sleep Health Promotion Interventions and Their Effectiveness: An Umbrella Review. Int J Environ Res Public Health. 2021. Baka A, van der Zweerde T, Lancee J, Bosmans JE, van Straten A. Cost-effectiveness of Guided Internet-Delivered Cognitive Behavioral Therapy in Comparison with Care-as-Usual for Patients with Insomnia in General Practice. Behav Sleep Med. 2021. Bakker MH, Hugtenburg JG, van Straten A, van der Horst HE, Slottje P. Effectiveness of low-dose amitriptyline and mirtazapine for insomnia disorder: study protocol of a randomised, double-blind, placebo-controlled trial in general practice (the DREAMING study). BMJ Open. 2021. Blanken TF, Jansson-Fröjmark M, Sunnhed R, Lancee J. Symptom-specific effects of cognitive therapy and behavior therapy for insomnia: A network intervention analysis. J Consult Clin Psychol. 2021.

Hermans LWA, Regis M, Fonseca P, Overeem S, Leufkens TRM, Vermeeren A, van Gilst MM. Assessing sleep-wake survival dynamics in relation to sleep quality in a placebo-controlled pharmacological intervention study with people with insomnia and healthy controls. Psychopharmacology (Berl). 2021. Kakar E, Venema E, Jeekel J, Klimek M, van der Jagt M. Music intervention for sleep quality in critically ill and surgical patients: a meta-analysis. BMJ Open. 2021. Krepel N, Egtberts T, Touré-Cuq E, Bouny P, Arns M. Evaluation of the URGOnight Tele-neurofeedback Device: An Open-label Feasibility Study with Follow-up. Appl Psychophysiol Biofeedback. 2021. Leerssen J, Lakbila-Kamal O, Dekkers LMS, Ikelaar SLC, Albers ACW, Blanken TF, Lancee J, van der Lande GJM, Maksimovic T, Mastenbroek SE, Reesen JE, van de Ven S, van der Zweerde T, Foster-Dingley JC, Van Someren EJW. Treating Insomnia with High Risk of Depression Using Therapist-Guided Digital Cognitive, Behavioral, and Circadian Rhythm Support Interventions to Prevent Worsening of Depressive Symptoms: A Randomized Controlled Trial. Psychother Psychosom. 2021.

Erten Uyumaz B, Feijs L, Hu J. A Review of Digital Cognitive Behavioral Therapy for Insomnia (CBT-I Apps): Are They Designed for Engagement? Int J Environ Res Public Health. 2021.

Rauwerda NL, Knoop H, Pot I, van Straten A, Rikkert ME, Zondervan A, Timmerhuis TPJ, Braamse AMJ, Boss HM. TIMELAPSE studyefficacy of low-dose amitriptyline versus cognitive behavioral therapy for chronic insomnia in patients with medical comorbidity: study protocol of a randomized controlled multicenter non-inferiority trial. Trials. 2021.

Fitrianie S, Horsch C, Beun RJ, Griffioen-Both F, Brinkman WP. Factors Affecting User's Behavioral Intention and Use of a MobilePhone-Delivered Cognitive Behavioral Therapy for Insomnia: A Small-Scale UTAUT Analysis. J Med Syst. 2021.

Saruhanjan K, Zarski AC, Bauer T, Baumeister H, Cuijpers P, Spiegelhalder K, Auerbach RP, Kessler RC, Bruffaerts R, Karyotaki E, Berking M, Ebert DD. Psychological interventions to improve sleep in college students: A meta-analysis of randomized controlled trials. J Sleep Res. 2021.

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NARCOLEPSY & HYPERSOMNIA

Narcolepsy and Central Disorders of Hypersomnolence (CDH) Central Disorders of Hypersomnolence are characterized by the complaint ‘excessive daytime sleepiness’, which goes hand in hand with ‘decreased vigilance’. Historically, hypersomnolence research in the Netherlands has always had a focus on both these aspects. In 2021, this has lead to several publications, varying from a paper covering the concept ‘vigilance’, to practical issues involving on-the-road-driving performance. In recent years, the treatment options for Central Disorders of Hypersomnolence have expanded. This has led to an updated treatment guideline with involvement of experts from The Netherlands. As part of these guidelines, even the diagnostic criteria for hypersomnolence disorders were critically appraised and found lacking. Together with other European experts a new classification concept has been proposed which will hopefully be adopted in the coming years. The last years were also characterized by the exciting development of hypocretin agonists. A clinical trial testing one of these compounds started in 2021. Unfortunately, it had to be stopped due to safety precautions. New trials will hopefully be initiated soon. To conclude, 2021 was also very much defined by COVID-19 and social distancing, which also had an impact on people with sleep disorders. This has led to a Dutch publication about this topic focusing on children with narcolepsy. Luckily, COVID-19 does not seem to be linked to the auto-immune development of narcolepsy type 1. Still, an incidence peak in 2013 was discovered last year, possible linked to viruses active that year. R O L F F R O N C Z E K , MD , P h D – S L E E P/ WA K E C E N T E R S E IN & L E ID E N U NI V E R S I T Y ME D I C A L C E N T E R .

Bassetti CLA, Kallweit U, Vignatelli L, Plazzi G, Lecendreux M, Baldin E, Dolenc-Groselj L, Jennum P, Khatami R, Manconi M, Mayer G, Partinen M, Pollmächer T, Reading P, Santamaria J, Sonka K, Dauvilliers Y, Lammers GJ. European guideline and expert statements on the management of narcolepsy in adults and children. Eur J Neurol. 2021 AND J Sleep Res. 2021.

a coin: differential response to COVID-19 distancing measures in children with narcolepsy. J Clin Sleep Med. 2021.

Bijlenga D, Urbanus B, van der Sluiszen NNJJM, Overeem S, Ramaekers JG, Vermeeren A, Lammers GJ. Comparing objective wakefulness and vigilance tests to on-the-road driving performance in narcolepsy and idiopathic hypersomnia. J Sleep Res. 2021.

Santifort KM, Ives EJ, Fenn J, Raimondi F, Lourinho F, Mandigers PJJ, Bergknut N. Suspected acquired narcolepsy in 8 dogs. J Vet Intern Med. 2021.

Lindström M, Schinkelshoek M, Tienari PJ, Kukkonen JP, Renkonen R, Fronczek R, Lammers GJ, Itkonen O. Orexin-A measurement in narcolepsy: A stability study and a comparison of LC-MS/MS and immunoassays. Clin Biochem. 2021. Quaedackers L, Droogleever Fortuyn H, Van Gilst M, Lappenschaar M, Overeem S. Dissociative Symptoms are Highly Prevalent in Adults with Narcolepsy Type 1. Behav Sleep Med. 2021. Quaedackers L, Overeem S, Pillen S. Two sides of Page 34

Quaedackers L, Pillen S, Overeem S. Recognizing the Symptom Spectrum of Narcolepsy to Improve Timely Diagnosis: A Narrative Review. Nat Sci Sleep. 2021.

van der Sluiszen NNJJM, Urbanus B, Lammers GJ, Overeem S, Ramaekers JG, Vermeeren A. On-the-road driving performance of patients with central disorders of hypersomnolence. Traffic Inj Prev. 2021. van Schie MKM, Lammers GJ, Fronczek R, Middelkoop HAM, van Dijk JG. Vigilance: discussion of related concepts and proposal for a definition. Sleep Med. 2021.


Vringer M, Kornum BR. Emerging therapeutic targets for narcolepsy. Expert Opin Ther Targets. 2021.

SLEEP & BREATHING

Zhang Z, Gool JK, Fronczek R, Dauvilliers Y, Bassetti CLA, Mayer G, Plazzi G, Pizza F, Santamaria J, Partinen M, Overeem S,

Peraita-Adrados R, da Silva AM, Sonka K, Del Rio-Villegas R, Heinzer R, Wierzbicka A, Young P, Högl B, Manconi M, Feketeova E, Mathis J, Paiva T, Canellas F, Lecendreux M, Baumann CR, Lammers GJ, Khatami R. New 2013 incidence peak in childhood narcolepsy: more than vaccination? Sleep. 2021.

Sleep apnea research in the Netherlands Like last year, an impressive track record list has been observed in the field of sleep-disordered breathing when looking to the output from the different research groups and hospitals active in this area in the Netherlands. Altogether, 50+ papers were identified, including contributions in the area of dental sleep medicine and mandibular advancement therapy. Up to present, the focus in most studies is on patient selection, prediction of outcome, and treatment monitoring, mainly for non-CPAP therapies (like maxillomandibular advancement therapy, upper airway surgery, hypoglossal nerve stimulation, maxillo-mandibular osteotomy and bariatric surgery). There is also a rising interest for the role of obstructive sleep apnea in the context of atrial fibrillation (with 9 papers from 1 research group). Two groups were also successful in publishing a meta-analysis with different comparisons, reflecting the high level of available expertise and the outstanding quality of the research performed. This is certainly a good sign for more fresh fruit the coming years. P R O F. J O H A N V E R B R A E C K E N , M D A N T W E R P U N I V E R S I T Y H O S P I T A L A N D U N I V E R S I T Y O F A N T W E R P, B E L G I U M

SLEEP APNEA AND BREATHING-RELATED SLEEP DISORDERS Bird JD, Kalker A, Rimke AN, Chan JS, Chan G, Saran G, Jendzjowsky NG, Wilson RJA, Brutsaert TD, Sherpa MT, Day TA. Severity of central sleep apnea does not affect sleeping oxygen saturation during ascent to high altitude. J Appl Physiol. 2021. Bosschieter PFN, Schoustra E, de Vries N, Steinbusch MJL, Kasius KM, Ravesloot MJL. Daytime polysomnography to perform titration for upper airway stimulation in patients with obstructive sleep apnea. Sleep Breath. 2021.

den Ottelander B, Gaillard L, Yang S, de Goederen R, Bredero-Boelhouwer H, van Veelen ML, Tasker R, Joosten K, Mathijssen I. Adult Saethre-Chotzen Syndrome: A Unique Abnormal Breathing Pattern. J Craniofac Surg. 2021. Goossens GH. The air that we (do not) breathe: lower adipose tissue oxygen availability in patients with obesity hypoventilation syndrome? Int J Obes (Lond). 2021. Huang Z, Aarab G, Ravesloot MJL, Zhou N, Bosschieter PFN, van Selms MKA, den Haan C, de Vries N, Lobbezoo F, Hilgevoord AAJ. Page 35


Prediction of the obstruction sites in the upper airway in sleep-disordered breathing based on snoring sound parameters: a systematic review. Sleep Med. 2021.

Castro SMM, de Vries N. The effect of postoperative CPAP use on anastomotic and staple line leakage after bariatric surgery. Sleep Breath. 2021.

Jacquet W, De Meyer MMD, Remmers JE, Jahromi SAZ, Hambrook DA, Marks LAM. The acoustical and perceptual features of snore-related sounds in patients with obstructive sleep apnea sleeping with the dynamic mandibular advancement system MATRx plus®. Sleep Breath. 2021.

Schuitenmaker JM, van Dijk M, Oude Nijhuis RAB, Smout AJPM, Bredenoord AJ. Associations Between Sleep Position and Nocturnal Gastroesophageal Reflux: A Study Using Concurrent Monitoring of Sleep Position and Esophageal pH and Impedance. Am J Gastroenterol. 2021.

Linssen B, Bergman E, Klarenbeek P, Hoff E. Prevalence of obstructive sleep apnea at an outpatient memory clinic. Health Sci Rep. 2021. Linz B, Hohl M, Lang L, Wong DWL, Nickel AG, De La Torre C, Sticht C, Wirth K, Boor P, Maack C, Speer T, Jespersen T, Schotten U, Sanders P, Böhm M, Linz D. Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model. Heart Rhythm. 2021. Linz D, Homberg M, van der Velden RMJ, Bouman E, Buhre W, Simons SO. Sleep apnea, obesity and COPD depress respiration during catheter ablation procedures: Implications for transcutaneous carbon dioxide monitoring. Int J Cardiol. 2021. Logjes RJH, MacLean JE, de Cort NW, Poets CF, Abadie V, Joosten KFM, Resnick CM, TrindadeSuedam IK, Zdanski CJ, Forrest CR, Kruisinga FH, Flores RL, Evans KN, Breugem CC. Objective measurements for upper airway obstruction in infants with Robin sequence: what are we measuring? A systematic review. J Clin Sleep Med. 2021. Ravesloot MJL, Vonk PE, Maurer JT, Oksenberg A, de Vries N. Standardized framework to report on the role of sleeping position in sleep apnea patients. Sleep Breath. 2021. Reijers SNH, Nijland LMG, Bosschieter PFN, de Raaff CAL, Ravesloot MJL, van Veen RN, de

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Sondeijker CFW, Apperloo RC, Kalaykova SI, Baan F, Maertens JKM. Combined orthodontic and surgical treatment for a patient with Hallermann-Streiff-Francois syndrome, severe obstructive sleep apnea, and history of antiresorptive medication. Am J Orthod Dentofacial Orthop. 2021. Testelmans D, Spruit MA, Vrijsen B, Sastry M, Belge C, Kalkanis A, Gaffron S, Wouters EFM, Buyse B. Comorbidity clusters in patients with moderate-to-severe OSA. Sleep Breath. 2021. van der Plas PPJM, Yang S, Streppel M, Pullens B, Versnel SL, Koudstaal MJ, Wolvius EB, Mathijssen IMJ, Joosten KFM. Functional outcomes in patients with facial dysostosis and severe upper airway obstruction. Int J Oral Maxillofac Surg. 2021. Verbraecken J. Telemedicine in Sleep-Disordered Breathing: Expanding the Horizons. Sleep Med Clin. 2021. Veugen CCAFM, Teunissen EM, den Otter LAS, Kos MP, Stokroos RJ, Copper MP. Prediction of obstructive sleep apnea: comparative performance of three screening instruments on the apnea-hypopnea index and the oxygen desaturation index. Sleep Breath. 2021.


TREATMENT OF BREATHING-RELATED SLEEP DISORDERS Bosschieter PFN, Vonk PE, de Vries N, Ravesloot MJL. Position-dependent obstructive sleep apnea and its influence on treatment success of mandibular advancement devices. Sleep Breath. 2021. De Meyer MMD, Vanderveken OM, De Weerdt S, Marks LAM, Cárcamo BA, Chavez AM, Matamoros FA, Jacquet W. Use of mandibular advancement devices for the treatment of primary snoring with or without obstructive sleep apnea (OSA): A systematic review. Sleep Med Rev. 2021. den Teuling NGP, van den Heuvel ER, Aloia MS, Pauws SC. A latent-class heteroskedastic hurdle trajectory model: patterns of adherence in obstructive sleep apnea patients on CPAP therapy. BMC Med Res Methodol. 2021. Kooij L, Vos PJ, Dijkstra A, Roovers EA, van Harten WH. Video Consultation as an Adequate Alternative to Face-to-Face Consultation in Continuous Positive Airway Pressure Use for Newly Diagnosed Patients With Obstructive Sleep Apnea: Randomized Controlled Trial. JMIR Form Res. 2021. Linz D, Malfertheiner MV, Werner N, Lerzer C, Gfüllner F, Linz B, Zeman F, McEvoy RD, Arzt M, Baumert M. Nocturnal hypoxemic burden during positive airway pressure treatment across different central sleep apnea etiologies. Sleep Med. 2021. Randerath W, Verbraecken J, de Raaff CAL, Hedner J, Herkenrath S, Hohenhorst W, Jakob T, Marrone O, Marklund M, McNicholas WT, Morgan RL, Pepin JL, Schiza S, Skoetz N, Smyth D, Steier J, Tonia T, Trzepizur W, van Mechelen PH, Wijkstra P. European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea. Eur Respir Rev. 2021.

for the treatment of severe obstructive sleep apnea: an individual participant data meta-analysis. Sleep. 2021. van den Broek N, Broer L, Vandenbussche N, Tan I, Overeem S, Pillen S. Obstructive sleep apnea in people with intellectual disabilities: adherence to and effect of CPAP. Sleep Breath. 2021. Venema JAMU, Rosenmöller BRAM, de Vries N, de Lange J, Aarab G, Lobbezoo F, Hoekema A. Mandibular advancement device design: A systematic review on outcomes in obstructive sleep apnea treatment. Sleep Med Rev. 2021. Zhou N, Ho JTF, Huang Z, Spijker R, de Vries N, Aarab G, Lobbezoo F, Ravesloot MJL, de Lange J. Maxillomandibular advancement versus multilevel surgery for treatment of obstructive sleep apnea: A systematic review and meta-analysis. Sleep Med Rev. 2021.

DRUG-INDUCED SLEEP ENDOSCOPY (DISE) Bosschieter PFN, Vonk PE, de Vries N. The predictive value of drug-induced sleep endoscopy for treatment success with a mandibular advancement device or positional therapy for patients with obstructive sleep apnea. Sleep Breath. 2021. Dieleman E, Veugen CCAFM, Hardeman JA, Copper MP. Drug-induced sleep endoscopy while administering CPAP therapy in patients with CPAP failure. Sleep Breath. 2021. Zhou N, Ho JTF, de Vries N, Bosschieter PFN, Ravesloot MJL, de Lange J. Evaluation of drug-induced sleep endoscopy as a tool for selecting patients with obstructive sleep apnea for maxillomandibular advancement. J Clin Sleep Med. 2021.

Trzepizur W, Cistulli PA, Glos M, Vielle B, Sutherland K, Wijkstra PJ, Hoekema A, Gagnadoux F. Health outcomes of continuous positive airway pressure versus mandibular advancement device Page 37


SLEEP APNEA & CARDIOVASCULAR PROBLEMS Cowie MR, Linz D, Redline S, Somers VK, Simonds AK. Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021. Desteghe L, Hendriks JML, Heidbuchel H, Potpara TS, Lee GA, Linz D. Obstructive sleep apnoea testing and management in atrial fibrillation patients: a joint survey by the European Heart Rhythm Association (EHRA) and the Association of Cardiovascular Nurses and Allied Professions (ACNAP). Europace. 2021. Hendriks JM, Lee G, Desteghe L, Linz D. Sleep apnoea management in atrial fibrillation in clinical practice: key messages for health care professionals based on a joint survey by EHRA and ACNAP. Eur J Cardiovasc Nurs. 2021. Linz D, Linz B, Dobrev D, Baumert M, Hendriks JM, Pepin JL, Jespersen T. Personalized management of sleep apnea in patients with atrial fibrillation: An interdisciplinary and translational challenge. Int J Cardiol Heart Vasc. 2021. Linz B, Linz D. Atrial connexin dysregulation in sleep apnea patients undergoing cardiac surgery: Implications for postoperative atrial fibrillation? Heart Rhythm. 2021. Linz D, Linz B, Homberg M, Bouman E, Dobrev D, Hendriks JM, Simons SO. Obstructive respiratory events during procedural sedation and analgesia: Another WHY to routinely screen for sleep apnea before catheter ablation of atrial fibrillation. Int J Cardiol Heart Vasc. 2021.

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Linz D, Nattel S, Kalman JM, Sanders P. Sleep Apnea and Atrial Fibrillation. Card Electrophysiol Clin. 2021. Lisan Q, van Sloten T, Boutouyrie P, Laurent S, Danchin N, Thomas F, Guibout C, Perier MC, Dagnelie P, Henry RM, Schram MT, Heinzer R, Marques-Vidal P, van der Kallen CJ, Crijns HJ, van Greevenbroek M, Reesink K, Köhler S, Sastry M, Jouven X, Stehouwer CDA, Empana JP. Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European CommunityBased Cohort Studies. J Am Heart Assoc. 2021. Meijer PM, Oudman KWE, van der Leest S, Wempe JB, Coster JE, Wijkstra PJ, Duiverman ML. Nasal high flow therapy in heart failure patients with central sleep apnea: a report of disproportional occurrence of cardiac arrhythmias. Sleep Med. 2021. Verhaert DVM, Betz K, Gawałko M, Hermans ANL, Pluymaekers NAHA, van der Velden RMJ, Philippens S, Vorstermans B, Simons SO, den Uijl DW, Chaldoupi SM, Luermans JGLM, Westra SW, Lankveld T, Kadhim K, Pepin JL, van Steenwijk RP, Hol B, Schotten U, Sanders P, Vernooy K, Hendriks JM, Linz D. A VIRTUAL Sleep Apnoea management pathway For the work-up of Atrial fibrillation patients in a digital Remote Infrastructure: VIRTUAL-SAFARI. Europace. 2021.


DENTAL SLEEP MEDICINE Chung J, Lobbezoo F, van Selms MKA, Chattrattrai T, Aarab G, Mitrirattanakul S. Physical, psychological and socio-demographic predictors related to patients' self-belief of their temporomandibular disorders' aetiology. J Oral Rehabil. 2021. de Baat C, Verhoeff M, Ahlberg J, Manfredini D, Winocur E, Zweers P, Rozema F, Vissink A, Lobbezoo F. Medications and addictive substances potentially inducing or attenuating sleep bruxism and/or awake bruxism. J Oral Rehabil. 2021. Giovanni A, Giorgia A. The neurophysiological basis of bruxism. Heliyon. 2021. Kapagiannidou D, Koutris M, Wetselaar P, Visscher CM, van der Zaag J, Lobbezoo F. Association between polysomnographic parameters of sleep bruxism and attrition-type tooth wear. J Oral Rehabil. 2021. Kroese JM, Volgenant CMC, Crielaard W, Loos B, van Schaardenburg D, Visscher CM, Lobbezoo F. Temporomandibular disorders in patients with early rheumatoid arthritis and at-risk individuals in the Dutch population: a cross-sectional study. RMD Open. 2021. Kuang B, Li D, Lobbezoo F, de Vries R, Hilgevoord A, de Vries N, Huynh N, Lavigne G, Aarab G. Associations between sleep bruxism and other sleep-related disorders in adults: a systematic review. Sleep Med. 2021. Lavigne G, Kato T, Herrero Babiloni A, Huynh N, Dal Fabbro C, Svensson P, Aarab G, Ahlberg J, Baba K, Carra MC, Cunha TCA, Gonçalves DAG, Manfredini D, Stuginski-Barbosa J, Wieckiewicz M, Lobbezoo F. Research routes on improved sleep bruxism metrics: Toward a standardised approach. J Sleep Res. 2021.

Lobbezoo F, Aarab G. Dental sleep medicine in the dental curriculum: what should be the dot on the horizon? Sleep Breath. 2021. Lobbezoo F, Ahlberg J, Aarab G, Manfredini D. Why using 'harmless behaviour', 'risk factor' and 'protective factor' as terms describing the various possible consequences of bruxism is still the best option. J Oral Rehabil. 2021. Lobbezoo F, Verhoeff MC, Aarab G. Concerns regarding the published article "Effect of dopaminergic agonist group of drugs in treatment of sleep bruxism: A systematic review" by Bhattacharjee et al. J Prosthet Dent. 2021. Manfredini D, Ahlberg J, Lobbezoo F. Bruxism definition: Past, present, and future - What should a prosthodontist know? J Prosthet Dent. 2021. Manfredini D, Lobbezoo F. Sleep bruxism and temporomandibular disorders: A scoping review of the literature. J Dent. 2021. Thymi M, Lobbezoo F, Aarab G, Ahlberg J, Baba K, Carra MC, Gallo LM, De Laat A, Manfredini D, Lavigne G, Svensson P. Signal acquisition and analysis of ambulatory electromyographic recordings for the assessment of sleep bruxism: A scoping review. J Oral Rehabil. 2021. Verhoeff MC, Koutris M, van Selms MKA, Brandwijk AN, Heres MS, Berendse HW, van Dijk KD, Lobbezoo F. Is dopaminergic medication dose associated with self-reported bruxism in Parkinson's disease? A cross-sectional, questionnaire-based study. Clin Oral Investig. 2021. Wetselaar P, Vermaire EJH, Lobbezoo F, Schuller AA. The prevalence of awake bruxism and sleep bruxism in the Dutch adolescent population. J Oral Rehabil. 2021.

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Parasomnias & movement disorders It is good to see that more studies are emerging in the field of parasomnias. For instance, Brederoo and colleagues showed that fragmented sleep in particular is related to the occurrence of hallucinations. This supports the notion that fragmented sleep may be an important pathway for psychopathology. This may apply specifically to disturbed REM. The study of ‘Lucid dreaming’ may help us to learn more about this REM sleep stage. It is therefore interesting to see that new techniques such as VR-training may enhance lucid dreaming ability (Gott et al.). This may eventually open new avenues in the treatment of REM disturbances. Nonetheless there are already effective treatments for parasomnias such as nightmare disorder. It is promising that these can be effectively delivered remotely by inexperienced therapists and with relatively little time investment (Lancee et al.). Treatment knowledge is also an issue for restless legs syndrome. This disorder still receives relatively little attention. This is a missed opportunity since it is associated with significant personal burden and substantial cost (Trekwalder et al.). For this reason it is of major importance that professionals are better trained and educated (Deerenberg et al.) JA AP L ANCEE, PhD – UNIVERSIT Y OF AMSTERDAM, AMSTERDAM

Brederoo SG, de Boer JN, de Vries J, Linszen MMJ, Sommer IEC. Fragmented sleep relates to hallucinations across perceptual modalities in the general population. Sci Rep. 2021. Gott J, Bovy L, Peters E, Tzioridou S, Meo S, Demirel Ç, Esfahani MJ, Oliveira PR, Houweling T, Orticoni A, Rademaker A, Booltink D, Varatheeswaran R, van Hooijdonk C, Chaabou M, Mangiaruga A, van den Berge E, Weber FD, Ritter S, Dresler M. Virtual reality training of lucid dreaming. Philos Trans R Soc Lond B Biol Sci. 2021. Konkoly KR, Appel K, Chabani E, Mangiaruga A, Gott J, Mallett R, Caughran B, Witkowski S, Whitmore NW, Mazurek CY, Berent JB, Weber FD, Türker B, Leu-Semenescu S, Maranci JB, Pipa G, Arnulf I, Oudiette D, Dresler M, Paller KA. Real-time dialogue between experimenters and dreamers during REM sleep. Current Biology 2021. Lancee J, Effting M, Kunze AE. Telephone-guided imagery rehearsal therapy for nightmares: Efficacy and mediator of change. J Sleep Res. 2021. Waters F, Barnby JM, Blom JD. Hallucination, imagery, dreaming: reassembling stimulusindependent perceptions based on Edmund Page 40

Parish's classic misperception framework. Philos Trans R Soc Lond B Biol Sci. 2021.

RESTLESS LEGS Deerenberg C, Gould J, Andrews R. A call for better training in restless legs syndrome. Lancet Neurol. 2021. Trenkwalder C, Tinelli M, Sakkas GK, Dauvilliers Y, Ferri R, Rijsman R, Oertel W, Jaarsma J Socioeconomic impact of restless legs syndrome and inadequate restless legs syndrome management across European settings. Eur J Neurol. 2021.

REM-SLEEP BEHAVIOUR DISORDER Janzen A, Kogan RV, Meles SK, Sittig E, Renken RJ, Geibl FF, Booij J, Stormezand G, Luster M, Mayer G, Leenders KL, Oertel WH. Rapid Eye Movement Sleep Behavior Disorder: Abnormal Cardiac Image and Progressive Abnormal Metabolic Brain Pattern. Mov Disord. 2021. Kogan RV, Janzen A, Meles SK, Sittig E, Renken RJ, Gurvits V, Mayer G, Leenders KL, Oertel WH; REMPET Working Group. Four-Year Follow-up of 18Fluorodeoxyglucose Positron Emission Tomography-Based Parkinson’s Disease-Related Pattern Expression in 20 Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder Shows Prodromal Progression. Mov Disord. 2021.


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CARDIOVASCULAR & METABOLIC DISEASE Andriessen C, Schrauwen P, Hoeks J. The importance of 24-h metabolism in obesityrelated metabolic disorders: opportunities for timed interventions. Int J Obes (Lond). 2021. Bos MM, Goulding NJ, Lee MA, Hofman A, Bot M, Pool R, Vijfhuizen LS, Zhang X, Li C, Mustafa R, Neville MJ, Li-Gao R, Trompet S, Beekman M, Biermasz NR, Boomsma DI, de Boer I, Christodoulides C, Dehghan A, van Dijk KW, Ford I, Ghanbari M, Heijmans BT, Ikram MA, Jukema JW, Mook-Kanamori DO, Karpe F, Luik AI, Lumey LH, van den Maagdenberg AMJM, Mooijaart SP, de Mutsert R, Penninx BWJH, Rensen PCN, Richmond RC, Rosendaal FR, Sattar N, Schoevers RA, Slagboom PE, Terwindt GM, Thesing CS, Wade KH, Wijsman CA, Willemsen G, Zwinderman AH van Heemst D, Noordam R, Lawlor DA. Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses. BMC Med. 2021. Pienaar PR, Roden LC, Boot CRL, van Mechelen W, Twisk JWR, Lambert EV, Rae DE. Association between self-reported sleep duration and cardiometabolic risk in corporate executives. Int Arch Occup Environ Health. 2021. Prins HJ, Verbunt JA. Fatigue in Stroke, Do Not Underestimate the Role of Sleep Disorders: Comment on Poststroke Fatigue Association With Independence Levels. Arch Phys Med Rehabil. 2021. Page 42

Sawyer A, den Hertog K, Verhoeff AP, Busch V, Stronks K. Developing the logic framework underpinning a whole-systems approach to childhood overweight and obesity prevention: Amsterdam Healthy Weight Approach. Obes Sci Pract. 2021. Schipper SBJ, Van Veen MM, Elders PJM, van Straten A, Van Der Werf YD, Knutson KL, Rutters F. Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature. Diabetologia. 2021. van Dongen LH, de Goede P, Moeller S, Eroglu TE, Folke F, Gislason G, Blom MT, Elders PJM, Torp-Pedersen C, Tan HL. Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes. Resusc Plus. 2021. Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, Sung YJ, Bentley AR, Manning AK, Aschard H, Kilpeläinen TO, Ilkov M, Brown MR, Horimoto AR, Richard M, Bartz TM, Vojinovic D, Lim E, Nierenberg JL, Liu Y, Chitrala K, Rankinen T, Musani SK, Franceschini N, Rauramaa R, Alver M, Zee PC, Harris SE, van der Most PJ, Nolte IM, Munroe PB, Palmer ND, Kühnel B, Weiss S, Wen W, Hall KA, Lyytikäinen LP, O'Connell J, Eiriksdottir G, Launer LJ, de Vries PS, Arking DE, Chen H, Boerwinkle E, Krieger JE, Schreiner PJ, Sidney S, Shikany JM, Rice K, Chen YI, Gharib SA, Bis JC, Luik AI, Ikram MA, Uitterlinden AG, Amin N, Xu H, Levy D, He J, Lohman KK, Zonderman AB, Rice TK, Sims M,


Wilson G, Sofer T, Rich SS, Palmas W, Yao J, Guo X, Rotter JI, Biermasz NR, Mook-Kanamori DO, Martin LW, Barac A, Wallace RB, Gottlieb DJ, Komulainen P, Heikkinen S, Mägi R, Milani L, Metspalu A, Starr JM, Milaneschi Y, Waken RJ, Gao C, Waldenberger M, Peters A, Strauch K, Meitinger T, Roenneberg T, Völker U, Dörr M, Shu XO, Mukherjee S, Hillman DR, Kähönen M, Wagenknecht LE, Gieger C, Grabe HJ, Zheng W, Palmer LJ, Lehtimäki T, Gudnason V, Morrison AC, Pereira AC, Fornage M, Psaty BM, van Duijn CM, Liu CT, Kelly TN, Evans MK, Bouchard C, Fox ER, Kooperberg C, Zhu X, Lakka TA, Esko T, North KE, Deary IJ, Snieder H, Penninx BWJH, Gauderman WJ, Rao DC, Redline S, van Heemst D. Multiancestry genome-wide gene-sleep interactions

CANCER Barsasella D, Syed-Abdul S, Malwade S, Kuo TBJ, Chien MJ, Núñez-Benjumea FJ, Lai GM, Kao RH, Shih HJ, Wen YC, Li YJ, Carrascosa IP, Bai KJ, Broekhuizen YCB, Jaspers MWM. Sleep Quality among Breast and Prostate Cancer Patients: A Comparison between Subjective and Objective Measurements InHealthcare 2021.

Santoso AMM, Jansen F, Lissenberg-Witte BI, Baatenburg de Jong RJ, Langendijk JA, Leemans CR, Smit JH, Takes RP, Terhaard CHJ, van Straten A, Verdonck-de Leeuw IM; NET-QUBIC consortium. Poor sleep quality among newly diagnosed head and neck cancer patients: prevalence and associated factors Support Care Cancer. 2021. Schoormans D, van Es B, Mols F, Wasowicz D, Beijer S, Ezendam NPM. The relation between sleep quality, sleep quantity, and gastrointestinal problems among colorectal cancer survivors: result from the PROFILES registry. Support Care Cancer. 2022. Starreveld DEJ, Habers GEA, Valdimarsdottir HB, Kessels R, Daniëls LA, van Leeuwen FE, Bleiker EMA. Cancer-related Fatigue in Relation to Chronotype and Sleep Quality in (Non-)Hodgkin Lymphoma Survivors. J Biol Rhythms. 2021.

Bonhof CS, Van de Poll-Franse LV, de Hingh IH, Nefs G, Vreugdenhil G, Mols F. Association between peripheral neuropathy and sleep quality among colorectal cancer patients from diagnosis until 2-year follow-up: results from the PROFILES registry. J Cancer Surviv. 2021.

Starreveld DEJ, Daniels LA, Kieffer JM, Valdimarsdottir HB, de Geus J, Lanfermeijer M, van Someren EJW, Habers GEA, Bosch JA, Janus CPM, van Spronsen DJ, de Weijer RJ, Marijt EWA, de Jongh E, Zijlstra JM, Böhmer LH, Houmes M, Kersten MJ, Korse CM, van Rossum HH, Redd WH, Lutgendorf SK, Ancoli-Israel S, van Leeuwen FE, Bleiker EMA. Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial Cancers (Basel). 2021.

de Winter J, Ezendam NPM, Bours MJL, Winkels RM, Weijenberg MP, Kampman E, Vissers PAJ, Mols F, Beijer S. Is sleep associated with BMI, waist circumference, and diet among long-term colorectal cancer survivors? Results from the population-based PROFILES registry. Support Care Cancer. 2021.

van Hulst AM, Peersmann SHM, van den Akker ELT, Schoonmade LJ, van den Heuvel-Eibrink MM, Grootenhuis MA, van Litsenburg RRL. Risk factors for steroid-induced adverse psychological reactions and sleep problems in pediatric acute lymphoblastic leukemia: A systematic review Psychooncology. 2021.

Santoso AMM, Jansen F, Lissenberg-Witte BI, Baatenburg de Jong RJ, Langendijk JA, Leemans CR, Smit JH, Takes RP, Terhaard CHJ, van Straten A, Verdonck-de Leeuw IM. Sleep quality trajectories from head and neck cancer diagnosis to six months after treatment. Oral Oncol. 2021.

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COVID-19 & SLEEP Ammar A, Trabelsi K, Brach M, Chtourou H, Boukhris O, Masmoudi L, Bouaziz B, Bentlage E, How D, Ahmed M, Mueller P, Mueller N, Hammouda O, Paineiras-Domingos LL, BraakmanJansen A, Wrede C, Bastoni S, Pernambuco CS, Mataruna L, Taheri M, Irandoust K, Khacharem A, Bragazzi NL, Strahler J, Adrian J, Andreeva A, Glenn JM, Bott NT, Gargouri F, Chaari L, Batatia H, Khoshnami SC, Samara E, Zisi V, Sankar P, Ahmed WN, Ali GM, Abdelkarim O, Jarraya M, Abed KE, Moalla W, Romdhani M, Aloui A, Souissi N, Lisette Van Gemert P, Riemann BL, Riemann L, Delhey J, Gómez-Raja J, Epstein M, Sanderman R, Schulz S, Jerg A, Al-Horani R, Mansi T, Jmail M, Barbosa F, Ferreira-Santos F, Šimunic B, Pišot R, Pišot S, Gaggioli A, Zmijewski P, Bailey SJ, Steinacker J, Chamari K, Driss T, Hoekelmann A. Effects of home confinement on mental health and lifestyle behaviours during the COVID-19 outbreak: insights from the ECLB-COVID19 multicentre study. Biol Sport. 2021. de Kruif MD, Voncken SFJ, Laven SAJS, Feron TMH, Kolfoort-Otte AAB. Obstructive Sleep Apnea and Risk of COVID-19 Infection, Hospitalization and Respiratory Failure. Sleep Breath. 2021. Du C, Zan MCH, Cho MJ, Fenton JI, Hsiao PY, Hsiao R, Keaver L, Lai CC, Lee H, Ludy MJ, Shen W, Swee WCS, Thrivikraman J, Tseng KW, Tseng WC, Almotwa J, Feldpausch CE, Folk SYL, Gadd S, Wang L, Wang W, Zhang X, Tucker RM. Health Behaviors of Higher Education Students from 7 Countries: Poorer Sleep Quality during the COVID-19 Pandemic Predicts Higher Dietary Risk. Clocks Sleep. 2021. Ho JPTF, Donders HCM, Zhou N, Schipper K, Su N, de Lange J. Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study. PLoS One. 2021.

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Lammers-van der Holst HM, Lammers GJ, van der Horst GTJ, Chaves I, de Vries RD, Geurts van Kessel CH, Koch B, van der Kuy HM. Understanding the association between sleep, shift work and COVID-19 vaccine immune response efficacy: Protocol of the S-CORE study. J Sleep Res. 2021. Trabelsi K, Ammar A, Masmoudi L, Boukhris O, Chtourou H, Bouaziz B, Brach M, Bentlage E, How D, Ahmed M, Mueller P, Mueller N, Hsouna H, Romdhani M, Hammouda O, Paineiras-Domingos LL, Braakman-Jansen A, Wrede C, Bastoni S, Pernambuco CS, Mataruna-Dos-Santos LJ, Taheri M, Irandoust K, Khacharem A, Bragazzi NL, Strahler J, Adrian Washif J, Andreeva A, Bailey SJ, Acton J, Mitchell E, Bott NT, Gargouri F, Chaari L, Batatia H, Khoshnami SC, Samara E, Zisi V, Sankar P, Ahmed WN, Ali GM, Abdelkarim O, Jarraya M, El Abed K, Moalla W, Souissi N, Aloui A, Souissi N, Gemert-Pijnen LV, Riemann BL, Riemann L, Delhey J, Gómez-Raja J, Epstein M, Sanderman R, Schulz S, Jerg A, Al-Horani R, Mansi T, Dergaa I, Jmail M, Barbosa F, Ferreira-Santos F, Šimunic B, Pišot R, Pišot S, Gaggioli A, Steinacker J, Zmijewski P, Clark CCT, Apfelbacher C, Glenn JM, Saad HB, Chamari K, Driss T, Hoekelmann A. Globally altered sleep patterns and physical activity levels by confinement in 5056 individuals: ECLB COVID-19 international online survey. Biol Sport. 2021. Trabelsi K, Ammar A, Masmoudi L, Boukhris O, Chtourou H, Bouaziz B, Brach M, Bentlage E, How D, Ahmed M, Mueller P, Mueller N, Hsouna H, Elghoul Y, Romdhani M, Hammouda O, Paineiras-Domingos LL, Braakman-Jansen A, Wrede C, Bastoni S, Pernambuco CS, Mataruna-Dos-Santos LJ, Taheri M, Irandoust K, Bragazzi NL,Strahler J, Washif JA, Andreeva A, Bailey SJ, Acton J, Mitchell E, Bott NT, Gargouri F, Chaari L, Batatia H, Khoshnami SC, Samara E, Zisi V, Sankar P, Ahmed WN, Ali GM, Abdelkarim O, Jarraya M, Abed KE, Moalla W, Souissi N, Aloui A, Souissi N, Gemert-Pijnen LV, Riemann BL, Riemann L, Delhey J, Gómez-Raja J, Epstein M, Sanderman R, Schulz S, Jerg A, Al-Horani R, Mansi T, Dergaa I, Jmail M, Barbosa F,


Ferreira-Santos F, Šimunic B, Pišot R, Pišot S, Gaggioli A, Steinacker J, Zmijewski P, Apfelbacher C, Glenn JM, Khacharem A, Clark CCT, Saad HB, Chamari K, Driss T, Hoekelmann A, On Behalf Of The Eclb-Covid Consortium. Sleep Quality and Physical Activity as Predictors of Mental Wellbeing Variance in Older Adults during COVID-19 Lockdown: ECLB COVID-19 International Online Survey. Int J Environ Res Public Health. 2021. van den Ende ES, van Veldhuizen KDI, Toussaint B, Merten H, van de Ven PM, Kok NA, Nanayakkara PWB. Hospitalized COVID-19 Patients Were Five Times More Likely to Suffer From Total Sleep Deprivation Compared to Non-COVID-19 Patients; an Observational Comparative Study. Front Neurosci. 2021. van Roekel H, van der Fels IMJ, Bakker AB, Tummers LG. Healthcare Workers Who Work With COVID-19 Patients Are More Physically Exhausted and Have More Sleep Problems. Front Psychol. 2021.

and progressive supranuclear palsy. Handb Clin Neurol. 2021. Fronczek R, Schinkelshoek M, Shan L, Lammers GJ. The orexin/hypocretin system in neuropsychiatric disorders: Relation to signs and symptoms. Handb Clin Neurol. 2021. Lamballais S, Adank MC, Hussainali RF, Schalekamp-Timmermans S, Vernooij MW, Luik AI, Steegers EAP, Ikram MA. Design and overview of the Origins of Alzheimer's Disease Across the Life course (ORACLE) study. Eur J Epidemiol. 2021. van Wamelen DJ, Urso D, Ray Chaudhuri K. How Time Rules: Diurnal Motor Patterns in de novo Parkinson's Disease. J Parkinsons Dis. 2021. van Egroo M, van Hooren RWE, Jacobs HIL. Associations between locus coeruleus integrity and nocturnal awakenings in the context of Alzheimer's disease plasma biomarkers: a 7T MRI study. Alzheimers Res Ther. 2021.

Voncken SFJ, Feron TMH, Laven SAJS, Karaca U, Beerhorst K, Klarenbeek P, Straetmans JMJAA, de Vries GJ, Kolfoort-Otte AAB, de Kruif MD. Impact of obstructive sleep apnea on clinical outcomes in patients hospitalized with COVID-19. Sleep Breath. 2021.

NEURODEGENEREATIVE DISEASES (PARKINSON/ALZHEIMER) Bayard S, Lebrun C, Arifi-Rossignol A, Geny C, Gély-Nargeot MC, Luik AI. Diagnostic Validity of the Sleep Condition Indicator to Screen for Diagnostic and Statistical Manual-5 Insomnia Disorder in Patients with Parkinson's Disease. Eur Neurol. 2021. Eeza MNH, Singer R, Höfling C, Matysik J, de Groot HJM, RoSSner S, Alia A. Metabolic Profiling of Suprachiasmatic Nucleus Reveals Multifaceted Effects in an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2021. Fifel K, De Boer T. The circadian system in Parkinson's disease, multiple system atrophy, Page 45


EPILEPSY Celli R, Luijtelaar GV. The orexin system: a potential player in the pathophysiology of absence epilepsy? Curr Neuropharmacol. 2021. Nobili L, de Weerd A, Rubboli G, Beniczky S, Derry C, Eriksson S, Halasz P, Högl B, Santamaria J, Khatami R, Ryvlin P, Rémi J, Tinuper P, Bassetti C, Manni R, Koutroumanidis M, Vignatelli L. Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe. consensus review. Eur J Neurol. 2021. Mierlo PV, Braakman H, Vandenbussche N, Schelhaas HJ, Pillen S. Epilepsy and Sleep in the ATR-X Syndrome. Neuropediatrics. 2021.

KFM, Mathijssen IMJ, Dremmen MHG. Cervical Spinal Cord Compression and Sleep-Disordered Breathing in Syndromic Craniosynostosis. AJNR Am J Neuroradiol. 2021. Holden SS, Grandi FC, Aboubakr O, Higashikubo B, Cho FS, Chang AH, Forero AO, Morningstar AR, Mathur V, Kuhn LJ, Suri P, Sankaranarayanan S, Andrews- Zwilling Y, Tenner AJ, Luthi A, Aronica E, Corces MR, Yednock T, Paz JT. Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury. Science. 2021. Hulst RY, Gorter JW, Voorman JM, Kolk E, Van Der Vossen S, Visser-Meily JMA, Ketelaar M, Pillen S, Verschuren O. Sleep problems in children with cerebral palsy and their parents. Dev Med Child Neurol. 2021. Pilon L, Frankenmolen N, Bertens D. Treatments for sleep disturbances in individuals with acquired brain injury: A systematic review. Clin Rehabil. 2021. van den Munckhof B. Encephalopathy with Continuous Spikes and Waves during sleep: An evolving spectrum. Eur J Paediatr Neurol. 2021.

BRAIN INJURY & BRAIN DISEASE Bruijel J, van Heugten CM, Murray J, Grima N, Ymer L, Walters EM, Sinclair K, Stapert SZ, Vermeeren A, Ponsford JL. The bidirectional relationship between sleep and physical activity following traumatic brain injury. J Sleep Res. 2021. de Goederen R, Yang S, Pullens B, Wolvius EB, Joosten KFM, Mathijssen IMJ. Evaluation of the OSA treatment protocol in syndromic craniosynostosis during the first 6 years of life. J Plast Reconstr Aesthet Surg. 2021. den Ottelander BK, de Goederen R, de Planque CA, Baart SJ, van Veelen MLC, Corel LJA, Joosten Page 46

van Gorp M, Dallmeijer AJ, van Wely L, de Groot V, Terwee CB, Flens G, Stam HJ, van der Slot W, Roebroeck ME; PERRIN DECADE Study Group. Pain, fatigue, depressive symptoms and sleep disturbance in young adults with cerebral palsy. Disabil Rehabil. 2021. Verschuren O, Hulst RY, Voorman J, Pillen S, Luitwieler N, Dudink J, Gorter JW. 24-hour activity for children with cerebral palsy: a clinical practice guide. Dev Med Child Neurol. 2021.

OTHER Dylag KA, Bando B, Baran Z, Dumnicka P, Kowalska K, Kulaga P, Przybyszewska K, Radlinski J, Roozen S, Curfs L. Sleep problems among children with Fetal Alcohol Spectrum Disorders (FASD)- an explorative study. Ital J Pediatr. 2021.


Habers GEA, van der Helm-van Mil AHM, Veldhuijzen DS, Allaart CF, Vreugdenhil E, Starreveld DEJ, Huizinga TWJ, Evers AWM. Earlier chronotype in patients with rheumatoid arthritis. Clin Rheumatol. 2021. Logjes RJH, Maclean JE, Breugem CC. Sleep Outcomes in Neonates with Pierre Robin Sequence Undergoing External Mandibular Distraction: A Longitudinal Analysis. Plast Reconstr Surg. 2021. Magno MS, Utheim TP, Snieder H, Hammond CJ, Vehof J. The relationship between dry eye and sleep quality. Ocul Surf. 2021. Mousavi SH, Hijmans JM, Minoonejad H, Rajabi R, Zwerver J. Factors Associated With Lower Limb Injuries in Recreational Runners: A CrossSectional Survey Including Mental Aspects and Sleep Quality. J Sports Sci Med. 2021. Pienaar PR, Kolbe-Alexander TL, van Mechelen W, Boot CRL, Roden LC, Lambert EV, Rae DE.

Associations Between Self-Reported Sleep Duration and Mortality in Employed Individuals: Systematic Review and Meta-Analysis. Am J Health Promot. 2021. Schaafsma A, Mallee L, van den Belt M, Floris E, Kortman G, Veldman J, van den Ende D, Kardinaal A. The Effect of A Whey-Protein and GalactoOligosaccharides Based Product on Parameters of Sleep Quality, Stress, and Gut Microbiota in Apparently Healthy Adults with Moderate Sleep Disturbances: A Randomized Controlled Cross-Over Study. Nutrients. 2021. van Woerkom M. A quasi-experimental study into the effects of naps and therapy glasses on fatigue and well-being. J Nurs Manag. 2021. You Y, Luo J, Elstgeest LEM, Zhang Y, Tan SS, Raat H. Associations between health indicators and sleep duration of American adults: NHANES 2011-16. Eur J Public Health. 2021.

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SLEEP & MENTAL HEALTH

Sleep and mental health: predictive capacities and treatment opportunities In these challenging times Dutch researchers have been quite productive in contributing to the growing amount of evidence for the close relationship between sleep and mental health. We see publications over a broad range of psychiatric disorders, from ADHD to bipolar disorder to PTSD. Most studies further disentangle sleep and sleep-wake pattern characteristics among and within psychiatric diagnoses. Such results are helpful, as these characteristics may reflect easily assessable predictors or biomarkers that might help shape the psychiatric treatment plan. Especially (but not solely) in the field of mood disorders this approach resulted in multiple interesting papers in the last year. That strategies to improve sleep in addition to regular psychiatric treatment help psychiatric patients recover faster, is something researchers in this field do not need to be convinced of anymore. A study confirming this approach once again comes from Van Andel et al. Still, an important task remains to disseminate this knowledge to psychiatric health care workers in general. We know that more Dutch sleep interventions studies are underway and look forward to the results in the coming years. J E A N I N E K A M P H U I S , P S Y C H I A T R I S T , P h D , U N I V E R S I T Y C E N T E R O F P S Y C H I A T R Y, G R O N I N G E N M A A IK E VA N V E E N , P S Y C H I AT R I S T / E P ID E M I O L O G I S T, C E N T E R OF E X P E R T ISE ON SL E E P & P S YC HI AT RY G G Z DR E N T HE , AS SE N

SLEEP & MENTAL HEALTH Arns M, Kooij JJS, Coogan AN. Review: Identification and Management of Circadian Rhythm Sleep Disorders as a Transdiagnostic Feature in Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry. 2021. Difrancesco S, Riese H, Merikangas KR, Shou H, Zipunnikov V, Antypa N, van Hemert AM, Schoevers RA, Penninx BWJH, Lamers F. Sociodemographic, Health and Lifestyle, Sampling, and Mental Health Determinants of 24-Hour Motor Activity Patterns: Observational Study. J Med Internet Res. 2021. de Crom SAM, Haan L, Schirmbeck F; GROUP investigators. The association between sleep disturbances and negative symptom severity in patients with non-affective psychotic disorders, unaffected siblings and healthy controls. Psychiatry Res. 2021. Lancel M, Boersma GJ, Kamphuis J. Insomnia disorder and its reciprocal relation with psychopathology. Curr Opin Psychol. 2021. Lu J, Huang ML, Li JH, Jin KY, Li HM, Mou TT, Fronczek R, Duan JF, Xu WJ, Swaab D, Bao AM. Changes of Hypocretin (Orexin) System in Page 48

Schizophrenia: From Plasma to Brain. Schizophr Bull. 2021. Oosterloo BC, de Feijter M, Croll PH, Baatenburg de Jong RJ, Luik AI, Goedegebure A. Cross-sectional and Longitudinal Associations Between Tinnitus and Mental Health in a Population-Based Sample of Middle-aged and Elderly Persons. JAMA Otolaryngol Head Neck Surg. 2021. Shan L, Fronczek R, Lammers GJ, Swaab DF. The tuberomamillary nucleus in neuropsychiatric disorders. Handb Clin Neurol. 2021. Sznitman SR, Shochat T, van Rijswijk L, Greene T, Cousijn J. Cannabis and Alcohol Use and Their Associations with Sleep: A Daily Diary Investigation of Single-Use and Co-Use in College Students. Cannabis Cannabinoid Res. 2021. Van Veen MM, Lancel M, Beijer E, Remmelzwaal S, Rutters F. The association of sleep quality and aggression: A systematic review and meta-analysis of observational studies. Sleep Med Rev. 2021. Vermeulen MCM, van der Heijden KB, Kocevska D, Treur JL, Huppertz C, van Beijsterveldt CEM,


Boomsma DI, Swaab H, Van Someren EJW, Bartels M. Associations of sleep with psychological problems and well-being in adolescence: causality or common genetic predispositions? J Child Psychol Psychiatry. 2021. Wijbenga RA, Blaauw FJ, Janus SIM, Tibben C, Smits AE, Oude Voshaar RC, Zuidema SU, Zuidersma M. Individual differences in the temporal relationship between sleep and agitation: a single-subject study in nursing home residents with dementia experiencing sleep disturbance and agitation. Aging Ment Health. 2021. Zuidersma M, Lugtenburg A, van Zelst W, Reesink FE, De Deyn PP, Strijkert F, Zuidema SU, Oude Voshaar RC. Temporal dynamics of depression, cognitive performance and sleep in older persons with depressive symptoms and cognitive impairments: a series of eight single-subject studies. Int Psychogeriatr. 2021.

MOOD DISORDERS Anujuo K, Stronks K, Snijder MB, Lok A, JeanLouis G, Agyemang C. Association between Depressed Mood and Sleep Duration among Various Ethnic Groups-The Helius Study. Int J Environ Res Public Health 2021. Difrancesco S, Penninx BWJH, Antypa N, van Hemert AM, Riese H, Lamers F. The day-to-day bidirectional longitudinal association between objective and self-reported sleep and affect: An ambulatory assessment study. J Affect Disord. 2021. Difrancesco S, Penninx BWJH, Riese H, Giltay EJ, Lamers F. The role of depressive symptoms and symptom dimensions in actigraphy-assessed sleep, circadian rhythm, and physical activity. Psychol Med. 2021.

Kanady JC, Carl JR, Davis ML, Kyle SD, Espie CA. Insomnia as a mediating therapeutic target for depressive symptoms: A sub-analysis of participant data from two large randomized controlled trials of a digital sleep intervention. J Sleep Res. 2021 Huiberts LM, Smolders KCHJ. Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway. Sleep Med Rev. 2021. Knapen SE, Li P, Riemersma-van der Lek RF, Verkooijen S, Boks MPM, Schoevers RA, Scheer FAJL, Hu K. Fractal biomarker of activity in patients with bipolar disorder. Psychol Med. 2021. Kunkels YK, Riese H, Knapen SE, Riemersma-van der Lek RF, George SV, van Roon AM, Schoevers RA, Wichers M. Efficacy of early warning signals and spectral periodicity for predicting transitions in bipolar patients: An actigraphy study. Transl Psychiatry. 2021. Minaeva O, George SV, Kuranova A, Jacobs N, Thiery E, Derom C, Wichers M, Riese H, Booij SH. Overnight affective dynamics and sleep characteristics as predictors of depression and its development in women. Sleep. 2021. Morssinkhof MWL, Lamers F, Hoogendoorn AW, de Wit AE, Riese H, Giltay EJ, van den Heuvel OA, Penninx BW, Broekman BFP. Oral contraceptives, depressive and insomnia symptoms in adult women with and without depression. Psychoneuroendocrinology. 2021. Rosenblum Y, Claassen JAHR. Day-to-day reciprocal associations between depressive symptoms, cognitive performance and sleep and the single-subject design. Int Psychogeriatr. 2021.

George SV, Kunkels YK, Booij S, Wichers M. Uncovering complexity details in actigraphy patterns to differentiate the depressed from the non-depressed. Sci Rep. 2021. Henry AL, Miller CB, Emsley R, Sheaves B, Freeman D, Luik AI, Littlewood DL, Saunders KEA, Page 49


ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) & AUTISM SPECTRUM DISORDER (ASD) Coll-Tané M, Gong NN, Belfer SJ, van Renssen LV, Kurtz-Nelson EC, Szuperak M, Eidhof I, van Reijmersdal B, Terwindt I, Durkin J, Verheij MMM, Kim CN, Hudac CM, Nowakowski TJ, Bernier RA, Pillen S, Earl RK, Eichler EE, Kleefstra T, Kayser MS, Schenck A. The CHD8/CHD7/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects. Sci Adv. 2021. Dorani F, Bijlenga D, Beekman ATF, van Someren EJW, Kooij JJS. Prevalence of hormone-related mood disorder symptoms in women with ADHD. J Psychiatr Res. 2021. Férat V, Arns M, Deiber MP, Hasler R, Perroud N, Michel CM, Ros T. EEG microstates as novel functional biomarkers for adult attention-deficit. hyperactivity disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Levelink B, van der Vlegel M, Mommers M, Gubbels J, Dompeling E, Feron FJM, van Zeben-van der Aa DMCB, Hurks P, Thijs C.

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The Longitudinal Relationship Between Screen Time, Sleep and a Diagnosis of Attention-Deficit/ Hyperactivity Disorder in Childhood. J Atten Disord. 2021. van Andel E, Bijlenga D, Vogel SWN, Beekman ATF, Kooij JJS. Effects of chronotherapy on circadian rhythm and ADHD symptoms in adults with attention-deficit/hyperactivity disorder and delayed sleep phase syndrome: a randomized clinical trial. Chronobiol Int. 2021.

POSTTRAUMATIC STRESS DISORDER (PTSD) Agorastos A, Olff M. Sleep, circadian system and traumatic stress. Eur J Psychotraumatol. 2021. Lancel M, van Marle HJF, Van Veen MM, van Schagen AM. Disturbed Sleep in PTSD: Thinking Beyond Nightmares. Front Psychiatry. 2021. Sopp MR, Michael T, Lass-Hennemann J, Haim-Nachum S, Lommen MJJ. Longitudinal associations between hair cortisol, PTSD symptoms, and sleep disturbances in a sample of firefighters with duty-related trauma exposure. Psychoneuroendocrinology. 2021.



NSWO

Nederlandse Vereniging voor Slaap- en Waakonderzoek


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