General pathology review

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5 LECTURES

3. Hemodynamic Disorder and Abnormalities of Blood Supply TO MASTER 1. The meanings or definitions of important terms in this chapter such as congestion, heart failure cell and thrombosis. 2. The concept, causes and morphologic characteristics of edema and describe ascites, hydrothorax and anasarca. 3. The concept, causes, pathological features and effects of congestion and describe the cause and pathological changes of liver and lung congestion. 4. The concept, etiology and pathogenesis of thrombosis (Virchow’s triad), and the type and consequences of thrombus. Compare the difference between thrombi and clots. 5. The concept and types of embolism and its influence on body. 6. The pathway of embolus travel. Name the most likely final destination of deep vein thrombosis. 7. The concept and types of infarction, and compare the morphological characteristics of various types of infarction. 1. THE MEANINGS OR DEFINITIONS OF IMPORTANT TERMS IN THIS CHAPTER SUCH AS CONGESTION, HEART FAILURE CELL AND THROMBOSIS. CONGESTION o A local increased volume of blood in a tissue may cause hyperemia or congestion. o Congestion is a passive process, resulting from impaired venous return from a tissue.

HEART FAILURE o Heart failure often called congestive heart failure. o Heart failure are of two types ::  RIGHT HEART FAILURE  Its mainly due to Hepatic venous congestion. They are of two types ::  Acute Hepatic Congestion :: the central hepatic veins and sinusoids are distended with blood, and there may be central hepatocyte degeneration.  Chronic Hepatic Congestion :: the central regions of hepatic lobules are grossly red-brown (due to cell death) and slightly depressed and are accentuated against surrounding zones of uncongested tan fatty liver (“nutmeg liver”)  LEFT HEART FAILURE  Its mainly due due to Pulmonary venous congestion. They are of two types ::

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