Li Ka Shing Insitute of Virology Annual Report 2017 by Li Ka Shing Institute of Virology

2017

Annual Report LKSIOV

TABLE OF CONTENTS 2017 Highlights

Governance

Li Ka Shing Institute of Virology Members

Principal Investigators

Trainees

Staff

Funding

Major Institute Investments

External Funding

Knowledge Transfer

Summary

Publications

Invited Presentations

Abstracts and Presentations

Media Engagements

Spin-Off Companies

Patents

Collaborating Institutes

Map of Collaborations

102

Research Excellence

105

Principal Investigator Honours and Awards

107

Trainee Awards

108

Sponsorship

111

LKSIOV Grant Award Programs

113

Educational Event Sponsorship

115

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

THE LKSIOV 2017 ANNUAL REPORT

The Li Ka Shing Institute of Virology was established on April 23, 2010 through combined gifts of $25 million from the Li Ka Shing (Canada) Foundation and a commitment of $52.5 million from the Government of Alberta.

Mission

Through leadership in scientific excellence and international collaboration, the Li Ka Shing Institute of Virology will invest in virology research to discover new methods to prevent, treat, and cure virus-related disease to reduce the burden of viral disease around the world.

LKSIOV 2017 highlights: 36 Members

Since Institute inception,

$2,796,542

in donations to research or educational activities

23 viruses from 14 virus families are studied

144 Trainees

104

Collaborating Departments, Universities, or Institutes

Affiliated with

11 Home

Departments in 2 Faculties at the University of Alberta

More than

92 Projects

supported by

$29,389,896

in acquired annual funds

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149

Peer-reviewed manuscripts

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GOVERNANCE Li Ka Shing Institute of Virology Oversight Committee D. Lorne Tyrrell, M.D., Ph.D. (Director, LKSIOV, ex officio) Michael Houghton, Ph.D. (Director, LKSAVI, ex officio) Richard Fedorak, M.D. (University of Alberta; Dean, FoMD) Matthias Götte, Ph.D. (University of Alberta; LKSIOV) Doug Goss, Q.C., A.O.E. (to be confirmed) (Counsel at Bryan & Company LLP) (Alberta Innovates) Laura Kilcrease, M.B.A. (or representative) Sandra Davidge, Ph.D. (University of Alberta; WCHRI) Walter Dixon, Ph.D. (to be confirmed) (University of Alberta; VP Research) Li Ka Shing Institute of Virology Management and Review Committee D. Lorne Tyrrell, M.D., Ph.D. (Director, LKSIOV, ex officio) Matthias Götte, Ph.D. (Chair, MMI Department, U of A, ex officio) Kristen Conn, Ph.D. (Research and Operations Manager, LKSIOV, ex officio) Maya Shmulevitz, Ph.D. (University of Alberta; LKSIOV) Troy Baldwin, Ph.D. (University of Alberta; LKSIOV) Renike Steenbergen, Ph.D. (University of Alberta; LKSIOV) Cameron Griffiths (University of Alberta; LKSIOV) Li Ka Shing Institute of Virology Scientific Advisory Board Chris Richardson, Ph.D. (Dalhousie University) Tim Block, Ph.D. (Baruch S. Blumburg Institute) Lorne Babiuk, Ph.D., D.Sc. (University of Alberta) Li Ka Shing Applied Virology Institute Scientific Advisory Board Devron Averett Ph.D. (Partner at AgriTitan LLC) Stephen Burley, Ph.D. (Rutgers School of Arts and Sciences) Walter Dixon, Ph.D. (University of Alberta; VP Research) Michael Gale Jr., Ph.D. (University of Washington) Tim Murphy, M.B.A. (Alberta Innovates) John McHutchison, M.D. (Head of Research and Development, Gilead) Amy Weiner, Ph.D. (Bill & Melinda Gates Foundation) Scientific Advisory Committee Translational Grants D. Lorne Tyrrell, M.D., Ph.D. (University of Alberta; Director, LKSIOV) Michael Houghton, Ph.D. (University of Alberta; Director, LKSAVI) Hans van de Sande, Ph.D. (University of Calgary) Bill Albritton, M.D., Ph.D. (University of Saskatchewan) Scientific Advisory Committee Immune Checkpoint Program Daniel Lamarre, Ph.D. (Université de Montréal) Amy Weiner, Ph.D. (Bill & Melinda Gates Foundation) Naglaa Shoukry, BPharm, Ph.D. (Université de Montréal) John Bell, Ph.D. (Ottawa Hospital Research Institute) Daniel Salamon, M.B.A. (Alberta Cancer Foundation)

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LI KA SHING INSTITUTE OF VIROLOGY MEMBERS

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Member Profiles

TROY BALDWIN

KHALED BARAKAT

CHRIS BLEACKLEY

• Associate Professor, Department of Medical Microbiology & Immunology

• Assistant Professor, Department of Pharmacy and Pharmaceutical Sciences

• Distinguished University Professor, Department of Biochemistry

Dr. Baldwin’s research interests include: • Thymocyte selection. • T cell responses. • Autoimmunity. • Intestinal homeostasis. • Animal models of human disease.

Dr. Barakat’s research interests include: • Computational drug design. • Computer simulations and computer modelling. • Bioinformatics. • Protein-protein interaction. • Immunotherapy. • HCV, HBV, Dengue, ZIKA antiviral drug discovery.

Dr. Bleakley’s research interests include: • Cytotoxic T lymphocytes. • Apoptosis. • Proteinases. • Cancer. • Autoimmunity. • Immunity to viruses.

PH.D.

PH.D., M.SC.

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PH.D.

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DEBORAH BURSHTYN

CARLOS CERVERA

KAREN DOUCETTE

• Vice-Dean, Faculty of Graduate Studies and Research • Professor, Department of Medical Microbiology & Immunology • Adjunct Professor, Department of Medical Genetics

• Assistant Professor, Division of Infectious Diseases, Department of Medicine • Medical Director, Transplant Infectious Diseases

• Associate Professor, Division of Infectious Diseases, Department of Medicine • Divisional Director, Division of Infectious Diseases, Department of Medicine • Section Chief of Infectious Diseases, Alberta Health Services • Education Director, Transplant Infectious Diseases Fellowship, University of Alberta • Education Director, Viral Hepatitis Fellowship, University of Alberta

PH.D.

Dr. Burshtyn’s research interests include: • Functional regulation of natural killer cells by inhibitory receptors. • Genetic variation of inhibitory receptors and the response to viruses (HCMV, poxviruses, HCV). • Viral manipulation of natural killer cell responses through inhibitory receptors. • Targeting natural killer cells with immunomodulatory molecules to treat cancer.

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M.D., PH.D.

M.D., M.SC., F.R.C.P.C.

Dr. Cervera’s research interests include: • CMV infection in solid organ transplant patients. • Viral reactivation and immunosenescence in immunocompromised patients. • Immunological aspects of CMV infection control in immunosuppressed patients.

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Dr. Doucette’s research interests include: • Epidemiology and outcomes of infections in organ transplant recipients. • Epidemiology and quality of care in viral hepatitis in immunocompromised and immune competent host. • Clinical trials.

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Member Profiles

DAVID EVANS PH.D., F.C.A.H.S.

• Associate Director, Li Ka Shing Institute of Virology • Vice-Dean, Research, Faculty of Medicine and Dentistry • Professor, Department of Medical Microbiology & Immunology • Chair, WHO Scientific Subcommittee on Variola Virus Research • Member, Advisory Committee on the Human Pathogens and Toxins, Public Health Agency of Canada • Chair, Faculty of Medicine and Dentistry Research Advisory Committee • Member, University of Alberta Research Policy Committee • Oversight Board, Women and Children’s Health Research Institute (WCHRI)

EDAN FOLEY

MATTHIAS GÖTTE

PH.D., M.SC.

• Professor, Department of Medical Microbiology & Immunology • Adjunct Professor, Department of Cell Biology • Director, University of Alberta Li Ka Shing Institute of Virology RNAi screening core Dr. Foley’s research interests include: • Innate immune signal transduction. • Intestinal immunity.

• Professor and Chair, Department of Medical Microbiology & Immunology • Adjunct Professor, McGill University, Departments of Microbiology & Immunology and Biochemistry Dr. Götte’s research interests include: • Infectious diseases with focus on Influenza, Herpesviruses, Zika virus, and Norovirus. • Discovery and development of antiviral agents. • Viral evolution and the emergence of resistance. • Viral genome replication.

Dr. Evan’s research interests include: • Poxvirus-host interactions. • Vaccinia virus replication and drug resistance mechanisms. • Vaccinia recombination mechanisms. • Vaccine vectors. • Oncolytic viruses.

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KLAUS GUTFREUND

MICHAEL HAWKES

BART HAZES

• Associate Professor, Department of Medicine, Division of Gastroenterology

• Assistant Professor, Division of Pediatric Infectious Diseases, Department of Pediatrics • Adjunct Assistant Professor, School of Public Health • Program Director, Pediatric Infectious Diseases Subspecialty Resident Training Program, University of Alberta • Medical Director, Clinical Investigation Unit (Pediatrics), University of Alberta

• Associate Professor, Department of Medical Microbiology & Immunology • Adjunct Associate Professor, Department of Biochemistry

M.D.

Dr. Gutfreund’s research interests include: • Hepatitis B. • Antiviral cellular immunity and immunotherapy. • Duck hepatitis B infection model.

M.D., PH.D., B.ENG., F.R.C.P.C.

Dr. Hawkes’ research interests include: • Global pediatric infectious diseases. • Malaria, Pneumonia, HIV.

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PH.D., M.SC.

Dr. Hazes’ research interests include: • Protein structure and function. • Bioinformatic studies of proteins and their evolution. • (Meta)genomics of bacteria and viruses. • Sequence-based viral epidemiology and typing.

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Member Profiles

DENISE HEMMINGS PH.D.

• Associate Professor, Department of Obstetrics and Gynecology • Adjunct Associate Professor, Department of Medical Microbiology & Immunology • Graduate Program Coordinator, Department of Obstetrics and Gynecology • Chair (Director), WISEST Dr. Hemmings’ research interests include: • Regulation of vascular tone by sphingosine 1-phosphate (S1P) through modulation of endothelial permeability. • Regulation of S1P during pregnancy and its role in vascular adaptations of pregnancy. • Impact of CMV on vascular function in pregnancy and aging. • The role of S1P in placental development and immune tolerance. • Impact of chronic CMV infections on cardiovascular and metabolic function in aging. • Role of CMV infections on breast cancer development, progression, and metastasis.

MARY HITT

TOM HOBMAN

• Associate Professor, Department of Oncology • Chair, Cancer Sciences Graduate Coordinating Committee

• Associate Dean, Research Facilities, Faculty of Medicine and Dentistry • Professor, Department of Cell Biology • Adjunct Professor, Department of Medical Microbiology & Immunology • Canada Research Chair (Tier I) in RNA viruses and host interactions

PH.D.

PH.D., M.SC.

Dr. Hitt’s research interests include: • Development of oncolytic viruses as a treatment for cancer. • Therapeutic uses of adenovirus and vaccinia virus derivatives, and strategies to enhance their tumorselectivity. • Pre-clinical testing of novel therapeutics. • Mechanisms of viral transformation.

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Dr. Hobman’s research interests include: • Interactions between flaviviruses (Zika virus, West Nile virus, Dengue virus) and host cells. • Molecular mechanisms of neurological disease in HIV (collaboration with Dr. Chris Power). • Identification of indirect antivirals for Zika virus and Dengue virus. • Novel diagnostics for Zika virus and Dengue virus. • Regulation of Argonaute 2 in RNA interference pathways.

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MICHAEL HOUGHTON

ROBERT INGHAM

PH.D.

• Director, Li Ka Shing Applied Virology Institute • Canada Excellence Research Chair in Virology and Li Ka Shing Professor, Department of Medical Microbiology & Immunology

• Associate Professor, Department of Medical Microbiology & Immunology

• Professor, Department of Medical Microbiology & Immunology

Dr. Ingham’s research interests include: • Mechanisms of cellular signalling. • Pathobiology of lymphoma. • Host-virus interactions. • Post-translational modifications and proteinprotein interactions.

Dr. Kane’s research interests include: • Immunology. • Natural killer cells. • Cytolytic T cells. • Receptors. • Virus infected cells, immune recognition. • Cancer cells, immune recognition.

Dr. Houghton’s research interests include: • HCV vaccine. • Autoimmune liver disease diagnosis. • Immune checkpoints drug design. • Role of IL28B in immunity. • Computational and biological tools to better predict drug cardiotoxicity. • Chronic fatigue syndrome diagnosis.

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KEVIN KANE PH.D.

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Member Profiles

NORMAN KNETEMAN

BONITA LEE

KATHARINE MAGOR

• Professor of Surgery, Division of General Surgery, Department of Surgery • Director, Division of Transplantation • Zone Clinical Section Chief, Transplants • Chair, Organ and Transplantation Donation Expert Advisory Committee, Canadian Blood Services/ Health Canada • Chairman, Transplant Council/ Transplant Management Committee, EDM-Alberta Health Services • President, KMT Hepatech Inc.

• Associate Professor, Division of Pediatric Infectious Diseases, Department of Pediatrics • Co-lead, Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE)

• Professor, Department of Biological Sciences • Adjunct Professor, Department of Medical Microbiology & Immunology

M.D., M.SC., F.R.C.S.C, F.A.C.S.

M.D., M.SC., F.R.C.P.

PH.D., M.SC.

Dr. Lee’s research interests include: • Infectious disease epidemiology. • Infection prevention and control. • Gastroenteritis virus and C. difficile. • Respiratory virus.

Dr. Kneteman’s research interests include: • Animal models of HCV, HBV, malaria: biology and therapeutics. • Chimeric mouse models for toxicity and metabolic evaluations. • Translational research interfaces and outcomes with liver transplantation, Hepatocellular carcinoma.

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Dr. Magor’s research interests include: • Host-pathogen interactions between influenza and its natural host, ducks. • Immunogenetics of the duck. • Immune gene families; MHC, lectin immunoreceptors, TRIM genes. • Regulation of RNA sensor, RIGI. • Host innate defenses, especially interferon stimulated genes. • Viral escape from innate immunity. • Interactions of influenza proteins with avian host proteins.

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DAVID MARCHANT

ANDREW MASON

HANNE OSTERGAARD

• Assistant Professor, Department of Medical Microbiology & Immunology • Canada Research Chair (Tier II) in Viral Pathogenesis

• Professor, Division of Gastroenterology, Department of Medicine • Adjunct Professor, Department of Medical Microbiology & Immunology • Director, The Applied Genomics Core, Core Sequencing Facility, University of Alberta • Director of Research, Liver Transplantation • Director of Research, Division of Gastroenterology

• Associate Dean Research, Graduate Programs, Faculty of Medicine & Dentistry • Professor, Department of Medical Microbiology & Immunology

PH.D., F.R.S.M.

Dr. Marchant’s research interests include: • Respiratory Syncytial Virus receptors and cellular entry. • Multi-tasking proteins. • Antiviral therapeutic development. • Community transmission of respiratory viruses.

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M.B.B.S., F.R.C.P.I., F.A.A.S.L.D.

Dr. Mason’s research interests include: • Retroviral pathogenesis of primary biliary cholangitis. • T and B lymphocyte immune responses to betaretrovirus infection. • Mouse models of betaretrovirus infection with autoimmune biliary disease. • Randomized controlled trials using antiretroviral therapy in primary biliary cholangitis. • Viral discovery using metagenomics approaches.

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PH.D.

Dr. Ostergaard’s research interests include: • Mechanisms of cytotoxic T lymphocyte (CTL) killing. • Regulation of CTL cytoskeletal rearrangements. • CTL responses to cancer. • Contribution of the tyrosine kinases Pyk2 to CTL migration and killing. • Role of the cytoskeletal adaptor proteins paxillin and leupaxin to leukocyte adhesion and migration.

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Member Profiles

XIAOLI LILLY PANG

JUTTA PREIKSAITIS

STEPHEN SHAFRAN

• Professor, Department of Laboratory Medicine & Pathology • Program Leader, Provincial Public Health Laboratory (Microbiology) • Co-lead, Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE)

• Professor, Division of Infectious Diseases, Department of Medicine • Adjunct Professor, Departments of Laboratory Medicine & Pathology, and Medical Microbiology & Immunology, School of Public Health • Director, Transplant Infectious Diseases Program, Department of Medicine

• Professor, Division of Infectious Diseases, Department of Medicine

M.D., PH.D.

Dr. Pang’s research interests include: • Viral gasteroenteritis: etiology and diagnosis of enteric viruses (norovirus, rotavirus, sapovirus, astrovirus, and enteric adenovirus). • Epochal evolution of GII norovirus associated with epidemic gastroenteritis and its relationship with host susceptibility and herd immunity, especially emerging GII.4 variants and its virulence for outbreaks. • Rotavirus host susceptibility and post-vaccine surveillance. • Environmental virology. • Diagnosis of human virus (CMV, EBV, BKV) infection in solid-organ transplantation recipients.

B.SC., M.D., F.R.C.P.C.

M.D., F.R.C.P., F.A.C.P, F.I.D.S.A.

Dr. Shafran’s research interests include: • Clinical trials of antiviral agents and viral vaccines. • Hepatitis C virus. • Human papillomavirus.

Dr. Preiksaitis’ research interests include: • Improved health care access and sustainability with microfluidic platforms. • Biomarkers of viral pathogenesis. • Improving the prevention, diagnosis, and treatment of post-transplant lymphoproliferative disorders after solid organ transplantation using peripheral blood and tissue biomarkers. • Toward improved outcomes in antithymocyte globulinconditioned hematopoietic cell transplantation. • Residual risk of transfusiontransmitted CMV infection: incidence and pathogenesis.

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MAYA SHMULEVITZ

JAMES SMILEY

GRAHAM TIPPLES

• Associate Professor, Department of Medical Microbiology & Immunology • Canada Research Chair (Tier II) in Molecular Virology and Oncotherapy

• Professor, Department of Medical Microbiology & Immunology • Canada Research Chair (Tier I) in Molecular Virology

• Medical/ Scientific Director, Provincial Laboratory for Public Health (ProvLab), Alberta Health Services • Adjunct Associate Professor, Department of Medical Microbiology & Immunology

PH.D.

Dr. Shmulevitz’s research interests include: • Reovirus. • Oncolytic viruses. • Antiviral state. • Virus-host relationships. • Virus structure-function. • Virus vectors.

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PH.D.

PH.D., F.C.C.M., D.(A.B.M.M.)

Dr. Smiley’s research interests include: • Virus-host interactions. • Innate immune responses to herpesviruses. • Viral modulation of translation and cellular stress responses. • Viral modulation of host signalling pathways.

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Dr. Tipples’ research interests include: • Public health microbiology. • Molecular epidemiology and surveillance. • Quality assurance. • Detection and characterization of emerging pathogens.

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Member Profiles

JACK TUSZYNSKI

GREGORY TYRRELL

D. LORNE TYRRELL

• Professor, Department of Physics • Allard Endowed Research Chair, Department of Experimental Oncology • Adjunct Professor, Departments of Medical Microbiology & Immunology and Biomedical Engineering

• Professor, Department of Laboratory Medicine & Pathology • Adjunct Professor, Department of Medical Microbiology & Immunology and Faculty of Pharmacy and Pharmaceutical Sciences • Divisional Director, Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine & Pathology • Program Director, Clinical Microbiology Fellowship Program, Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine & Pathology

• Founding Director, Li Ka Shing Institute of Virology • University Professor, Department of Medical Microbiology & Immunology • Adjunct Professor, Departments of Biochemistry and Medicine • Scientific Advisor, KMT Hepatech Inc. • GSK Chair in Virology • Chair, Gairdner Foundation Board • Chair, Institute of Health Economics Board

PH.D., D.SC.

Dr. Tuszynski’s research interests include: • Computational drug discovery. • Pharmacokinetic models. • Tubulin-targeting drugs. • Bio-nano-electronics.

PH.D., M.SC., F.C.C.M., D.(A.B.M.M.)

Dr. Tyrrell’s research interests include: • Group A and Group B streptococcal pathogenesis. • Group A and Group B streptococcal epidemiology. • Streptococcus pneumoniae epidemiology.

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M.D., PH.D., F.R.C.P., F.R.S.C.

Dr. Tyrrell’s research interests include: • Antiviral therapy for hepatitis B and C viruses. • Vaccine development for hepatitis C virus. • Animal models for hepatitis B and C viruses. • Viral escape from immune control. • Viral-host interaction: membranous web and nuclear pore proteins.

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GANE KA-SHU WONG

RICHARD WOZNIAK

STEPHANIE YANOW

• Professor, Department of Biological Sciences • Professor, Department of Medicine • AITF-iCORE Strategic Chair • Associate Director, BGI (Huádà Jīyīn)

• Professor, Department of Cell Biology

• Associate Professor in Global Health, School of Public Health • Adjunct Associate Professor, Department of Medical Microbiology & Immunology • Board of Governors Member, Student International Health Association, Community Engagement

PH.D.

Dr. Wong’s research interests include: • Sequencing of transcriptomes for Viridiplantae plant species, as the first phase of a larger biodiversity initiative. • Discovery and characterization of novel light-sensitive proteins, for optogenetics application in mammalian neurosciences. • Analysis of integration sites into the host genome for all known retroviruses. • New methods to detect low abundance DNA in clinical samples. • Gut bacterial metagenomics, within the context of fecal microbial transplantations. • Single cell analyses of metastasis progression in breast and prostate cancers.

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PH.D.

Dr. Wozniak’s research interests include: • Structure and function of nuclear pore complexes in yeast and mammalian cells. • Exploring the role of the nuclear envelope in the assembly and modulation of chromatin structure. • Analysis of the functions the nuclear pore complexes play in the epigenetic regulation of gene expression. • Examining the role of nuclear pore complex proteins in HCV and Zika virus infections. • Defining nuclear functions of the HCV and Zika virus genomes.

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Dr. Yanow’s research interests include: • Development of a “Lab-on-aChip” for malaria diagnosis. • Integrated molecular approaches to the diagnosis and epidemiology of pregnancy-associated malaria in Latin America. • Development of a chemicallyattenuated malaria blood stage vaccine. • A humanized mouse model for testing malaria vaccines.

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Trainees

TRAINEES The Mission of the Li Ka Shing Foundation is to inspire societal improvement through supporting education and healthcare initiatives. In the spirit of the dedicated commitment of the Li Ka Shing Foundation to education, the Li Ka Shing Institute of Virology is dedicated to providing outstanding quality education and training in virology, viral pathogenesis, immunology, infectious diseases, epidemiology, disease treatment, and disease prevention. Li Ka Shing Institute of Virology principal investigators and trainees have different home departments at the University of Alberta. Most members are associated with the Department of Medical Microbiology and Immunology, but members are also associated with the Departments of Biochemistry, Cell Biology, Surgery, and the Faculties of Science and Pharmacy. In 2017, the Li Ka Shing Institute of Virology was home to 144 trainees. We welcomed 43 new trainees and celebrated the successful defence of 8 Ph.D. and 5 M.Sc. theses.

Undergraduate Summer or Project Students

M.Sc. Candidates

Ph.D. Candidates

Postdoctoral Fellows

Interns

High School Student

M.D. Students

M.D./Ph.D. Candidate

Fellows/ Residents

CONGRATULATIONS TO OUR 2017 GRADUATES! Rhianna Charchuk, M.Sc. Ting Ting Chua, M.Sc. Hannah Jones, M.Sc. Chris Morcos, M.Sc. Ryan Stubbins, M.Sc.

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Juliana Capitanio, Ph.D. Dominic Golec, Ph.D. Shangmei Hou, Ph.D. Diego Lapetina, Ph.D. Ninad Mehta, Ph.D. Marianne Ngure, Ph.D. Kyle Potts, Ph.D. Ulrike Strunk, Ph.D.

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Welcome New Trainees! Hiatem Abofyed, M.D. 2017- present

Rui Chen 2017- present Mentor:

Khaled Barakat Position:

Mentor:

Andrew Mason Position:

M.Sc. Candidate, University of Alberta

Theinmozhi Arulraj 2017

M.Sc. Candidate, University of Alberta

Min-Haung Chiang 2017 Mentor:

Khaled Barakat Position:

Mentor:

Khaled Barakat Position:

Internship Student

Siddhartha Biswas, Ph.D. 2017- present

Internship Student

Tim Cho 2017- present Mentor:

Maya Shmulevitz Position:

Mentor:

B.Sc. Student Researcher, University of Alberta

David Evans Position:

Postdoctoral Fellow, University of Alberta

Gyan Darshan

Juliana Capitanio, Ph.D

2017

2009- 2017 (Ph.D. Candidate) 2017- present

Mentor:

Position:

Richard Wozniak

Internship Student

Current Position:

Kesia Dias

Postdoctoral Fellow, University of Alberta

Rigel Chan

Khaled Barakat

2017- present Mentor:

2017- 2018

Denise Hemmings

Mentor:

Position:

Troy Baldwin Position:

B.Sc. Student Researcher, University of Alberta

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Trainees

Magnolia Du

Vishrut Gulhati

2017

Mentor:

Position:

Mary Hitt AIHS HYRES student

Yuliya Fakhr

Michael Hawkes B.Sc. Student Researcher, University of Alberta

2017- present

Kristen Huntley

Mentor:

2017- present

Denise Hemmings Position:

M.Sc. Candidate, University of Alberta

Eric Flock 2017- present Mentor:

Mentor:

Denise Hemmings Position:

B.Sc. Student Researcher, University of Alberta

Oliver Jin

Robert Ingham

2017

Position:

Mentor:

B.Sc. Student Researcher, University of Alberta

Xiaoli Lilly Pang

Binal Gandhi, Ph.D.

B.Sc. Student Researcher, University of Alberta

2017- present Mentor:

Position:

John Johnson

Bonita Lee (co-supervisor)

2017

Position:

Mentor:

Postdoctoral Fellow, University of Alberta

Michael Hawkes

Matthew Gorman

Position:

2017- present Mentor:

Mary Hitt Position:

B.Sc. Student Researcher, University of Alberta

Diana Chiang Jurado 2017- present Mentor:

Carlos Cervera Position:

M.Sc. Candidate, University of Alberta

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Aarat Kalra

Julia May

2017- present

Mentor:

Position:

Zane Kliesmete

Charlotte McWilliams

2017

2017- present

Mentor:

Position:

Jack Tuszynski (co-mentor) M.Sc. Candidate, University of Alberta

Michael Hawkes Visiting Research Student from Germany

Vanessa Kohl 2017

David Evans M.Sc. Candidate, University of Alberta

Xiaoli Lilly Pang B.Sc. Student Researcher, University of Alberta

Ninad Mehta, Ph.D.

Mentor:

Mary Hitt

2014- 2017 (Ph.D. Candidate) 2017- present

Position:

Mentors:

M.Sc. Internship

Diego Lapetina, Ph.D 2009- 2017 (Ph.D. Candidate) 2017- present Mentor:

James Smiley (Ph.D.) Stephanie Yanow (PDF) Current Position:

Postdoctoral Fellow, University of Alberta

Qaasim Mian

Richard Wozniak

2017- present

Current Position:

Mentor:

Postdoctoral Fellow, University of Alberta

Michael Hawkes

Michelle Lee

Position:

2017- present

M.D. student, University of Alberta

Monika Mierzejewski

Mentor:

Katharine Magor

2017

Position:

Mentor:

B.Sc. Student Researcher, University of Alberta

Edan Foley Position:

B.Sc. Student Researcher, University of Alberta

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Trainees

Akihiro Nishiyama

Julia Sawatsky

2017- present

Mentor:

Position:

Andrew Panteluk

Minjeong Shin, Ph.D.

2017- present

Mentor:

Position:

Jack Tuszynski Postdoctoral Fellow, University of Alberta

Edan Foley B.Sc. Student Researcher, University of Alberta

Xu Jing Qian 2017- present Mentor:

Troy Baldwin Position:

B.Sc. Student Researcher, University of Alberta

Urvi Rai 2017 Mentor:

Michael Hawkes Position:

B.Sc. Student Researcher, University of Alberta

Matthew Reeves 2017- present Mentor:

Katharine Magor Position:

B.Sc. Student Researcher, University of Alberta

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Michael Hawkes M.D. student, University of Alberta

Edan Foley Postdoctoral Fellow, University of Alberta

Natalie Snyder 2017 Mentor:

Mary Hitt Current Position:

B.Sc. Student Summer Researcher, University of Alberta

Chase Stevens 2017- present Mentor:

Katharine Magor Position:

B.Sc. Student Researcher, University of Alberta

Jack Undershultz 2017- present Mentor:

Michael Hawkes Position:

M.D. student, University of Alberta

THE LKSIOV 2017 ANNUAL REPORT 23 | P a g e

Greg Valle 2017- present Mentor:

Continuing Trainees and 2017 Graduates

Denise Hemmings

Christopher Ablenas

Position:

2010- present

B.Sc. Student Researcher, University of Alberta

Jason Wong

Mentor:

Matthias GĂśtte Position:

2017- present

Ph.D. Candidate, McGill University

Mentor:

Marawan Ahmed, Ph.D.

Tom Hobman Position:

M.Sc. Candidate, University of Alberta

Young Zhou 2017

Mentor:

Klaus Gutfreund Position:

B.Sc. Pharm. Student Summer Researcher, University of Alberta

2014- present Mentor:

Khaled Barakat Position:

Postdoctoral Fellow, University of Alberta

Adriana Airo 2014- present Mentor:

Tom Hobman Position:

Ph.D. Candidate, University of Alberta

Sahar Arabimoghadam 2016- present Mentor:

Jack Tuszynski Position:

Ph.D. Candidate, University of Alberta

Baraâ&#x20AC;&#x2122;ah Azaizeh 2016- present Mentor:

Deborah Burshtyn Position:

M.Sc. Candidate, University of Alberta

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LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Trainees

Clayton Bell

Sammuel Cheung, Ph.D.

2015- present

Mentor:

Position:

Mariusz Bral

Tiing Tiing Chua

2016- present

2014- 2017 (M.Sc. Candidate)

Mentor:

Position:

Current Position:

Jack Tuszynski (co-mentor) M.Sc. Candidate, University of Alberta

Norman Kneteman Fellow, University of Alberta

Lee Campbell

Hanne Ostergaard Postdoctoral Fellow, University of Alberta

D Lorne Tyrrell Research Officer, Clinical Research Centre, Sibu Hospital, Malaysia

2016- present

Francisca Cristi

Mentor:

2016- present

Katharine Magor Position:

M.Sc. Candidate, University of Alberta

Adam Caulfield

Mentors:

Mary Hitt and Maya Shmulevitz Position:

Ph.D. Candidate, University of Alberta

2014- present

Powel Crosley

Mentor:

2016- present

Stephanie Yanow Position:

Mentor:

Mary Hitt

B.Sc. Student Researcher, University of Alberta

Position:

Rhianna Charchuk

Khaled Dajani

2014- 2017

2016- present

Mentor:

Current Position:

Position:

Michael Hawkes M.Sc. Candidate, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

M.Sc. Candidate, University of Alberta

Norman Kneteman Fellow, University of Alberta

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Saeideh Davoodi

David Fast

2015- present

2014- present

Mentor:

Position:

Jennifer Dobson

Nawell Fayad

2016- 2017

2013- 2017

Mentor:

Position:

Jianing Dong

Tianhua Feng

2016- present

Mentor:

Position:

Farah Elawar

Meghan Ferguson

2016- present

Mentor:

Position:

Danyel Evseev

Jason Fernandes

2012- present

2016- present

Mentor:

Position:

Edan Foley

Ph.D. Candidate, University of Alberta

Maya Shmulevitz B. Sc. Pharm. Student Summer Researcher, University of Alberta

Robert Ingham Ph.D. Candidate, University of Alberta

David Marchant Ph.D. Candidate, University of Alberta

Katharine Magor Ph.D. Candidate, University of Alberta

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THE LKSIOV 2017 ANNUAL REPORT

Ph.D. Candidate, University of Alberta

Stephanie Yanow B.Sc. Student Researcher, University of Alberta

Khaled Barakat M.Sc. Candidate, University of Alberta

Edan Foley M.Sc. Candidate, University of Alberta

Maya Shmulevitz B.Sc. Student Researcher, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Trainees

Chad Fibke

Francesco Gentile

2016- 2017

2014- present

Mentor:

Position:

Tom Hobman B.Sc. Student Researcher, University of Alberta

Daniel Friedman, M.D. 2016- present Mentor:

Karen Doucette Position:

Internal Medicine Resident, Graduate Student Translational Medicine, University of Alberta

Anthony Galenza 2014- present Mentor:

Edan Foley Position:

Ph.D. Candidate, University of Alberta

Aravindhan Ganesan, Ph.D. 2015- present Mentor:

Khaled Barakat Position:

Postdoctoral Fellow, University of Alberta

Kenneth Gavina 2013- present Mentor:

Stephanie Yanow Position:

Ph.D. Candidate, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Khaled Barakat Ph.D. Candidate, University of Alberta

Dominic Golec, Ph.D. 2012- 2017 (Ph.D. Candidate) Mentor:

Troy Baldwin Current Position:

Postdoctoral Fellow, Alberta Diabetes Institute, University of Alberta

Cameron Griffiths 2013- present Mentor:

David Marchant Position:

Ph.D. Candidate, University of Alberta

Donald Grynoch 2016- 2017 Mentor:

Jutta Preiksaitis Position:

B.Sc. Student Summer Researcher, University of Alberta

Cynthia Gunaratnam 2015- 2017 Mentor:

Michael Hawkes Position:

Pediatrics Resident

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Patrick Guo

Zaikun Hu, Ph.D.

2016- present

2013- present

Mentor:

Position:

Eloissa Hasing, Ph.D.

Chad Irwin, Ph.D.

2016- present

2013- 2017 (Postdoctoral Fellow)

Mentor:

Position:

Current Position:

Nawreen Hena

Kristen Irwin

2016- present

2016- 2017

Mentor:

Curent Position:

Position:

Christina Hernandez, Ph.D.

Lionel Jensen

2015- 2017 (Postdoctoral Fellow)

2013- present

Mentor:

Current Position:

Position:

Shangmei Hou, Ph.D

Janelle Johnson

2011- 2017 (Ph.D. Candidate)

2016- present

Mentor:

Current Position:

Position:

Andrew Mason Ph.D. Candidate, University of Alberta

Xiaoli Lilly Pang Postdoctoral Fellow, University of Alberta

Khaled Barakat B.Sc. Student Researcher, University of Alberta

Jutta Preiksaitis Transplant Infectious Diseases Fellow

Tom Hobman Clinical Research Coordinator, Vancouver

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THE LKSIOV 2017 ANNUAL REPORT

Tom Hobman Postdoctoral Fellow, University of Alberta

David Evans Traveller

Robert Ingham B.Sc. Student Researcher, University of Alberta

David Marchant M.Sc. Candidate, University of Alberta

Michael Houghton M.Sc. Candidate, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Trainees

Hannah Jones

Anil Kumar, Ph.D.

2015- 2017 (M.Sc. Candidate)

2014- present

Mentor:

Current Position:

Position:

Michael Hawkes Research Project Coordinator, Faculty of Nursing, University of Alberta

Subha Kalyaanamoorthy, Ph.D. 2016- present Mentor:

Khaled Barakat Position:

Postdoctoral Fellow, University of Alberta

Quinten Keiser 2016- present Mentor:

David Evans Position:

M.Sc. Candidate, University of Alberta

Rees Kelly 2015- present Mentor:

Troy Baldwin Position:

M.Sc. Candidate, University of Alberta

Benjamin Kostiuk 2016- present Mentor:

Maya Shmulevitz Position:

Ph.D. Candidate, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Tom Hobman Postdoctoral Fellow, University of Alberta

Connie Le 2014- present Mentor:

D Lorne Tyrrell Position:

M.D./ Ph.D. Candidate, University of Alberta

Daniel Limonta, Ph.D. 2015- present Mentor:

Tom Hobman Position:

Postdoctoral Fellow, University of Alberta

Colin Lloyd 2016- present Mentor:

Bonita Lee (co-supervisor) Position:

M.Sc. Candidate, University of Alberta

Crystal Lui 2016- present Mentor:

Khaled Barakat Position:

B.Sc. Student Researcher, University of Alberta

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Cary Ma

Justin Mergl

2016- present

2013- present

Mentor:

Position:

Sarah Mansour, M.D.

Kero Messeha

2016- present

Mentor:

Position:

Sai Mao

Catherine Mitran

2013- present

2016- present

Mentor:

Position:

Michael Hawkes M.D. student, University of Alberta

Karen Doucette Viral Hepatitis Fellow, University of Alberta

Katharine Magor (co-mentor) Ph.D. Candidate, Sichuan Agricultural University, China

Angie Mena 2016- present

Matthias Gรถtte M.Sc. Candidate, McGill University

Andrew Mason M.Sc. Candidate, University of Alberta

Stephanie Yanow Ph.D. Candidate, University of Alberta

Victor Mocanu 2016- 2017 Mentor:

Mentor:

Stephanie Yanow

Michael Hawkes Position:

osition:

M.Sc. Candidate, University of Alberta

B.Sc. Student Researcher, University of Alberta

Michael Menni

Adil Mohammed

2014- present

2011- present

Mentor:

Position:

Matthias Gรถtte M.Sc. Candidate, University of Alberta/ McGill University

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Maya Shmulevitz Ph.D. Candidate, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Trainees

Jonathan Mora

Brendon Parson, Ph.D.

2016- present

2015- present

Mentor:

Position:

Chris Morcos

Kyle Potts, Ph.D.

2014- 2017 (M.Sc. Candidate)

2011- 2017 (Ph.D. Candidate)

Mentor:

Mentors:

Current Position:

Mahshad Moshari

Jordane Preto

2015- present

Mentor:

Position:

Marianne Ngure, Ph.D.

Tamara Radovic

2011- 2017 (Ph.D. Candidate, McGill University/ University of Alberta)

2015- present

Mentor:

Maya Shmulevitz

Norman Kneteman M.Sc. Candidate, University of Alberta

Deborah Burshtyn Marketing Associate at AstraZeneca

Jack Tuszynski (co-mentor) Ph.D. Candidate, University of Alberta

Matthias Gรถtte

Bonita Lee (co-supervisor) Postdoctoral Fellow, University of Alberta

Mary Hitt and David Evans Postdoctoral Fellow, University of Calgary

Jack Tuszynski Postdoctoral Fellow, University of Alberta

Mentor:

Position:

Current Position:

GSK, Calgary AB

B.Sc. Student Researcher, University of Alberta

Sara Ibrahim Omar

Parisa Raeisimakiani

2013- present

2016- present

Mentor:

Jack Tuszynski Position:

Ph.D. Candidate, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Matthias Gรถtte Position:

Ph.D. Candidate, University of Alberta

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Maryam Rezaeeaval, M.D.

Amanda Scott

2016- present

2010- present

Mentor:

Position:

Current Position:

Karl Roesner

Mira Shenouda

2016- present

Mentor:

Position:

Brett Roughead

Jeremy Soo

2016- present

Mentor:

Position:

Natasha Saik

Janet Sperling

2015- present

2014- present

Mentor:

Position:

Kalutota Samarasinghe

Quinn Storozynsky

2017

2016- present

Mentor:

Position:

Karen Doucette Internal Medicine Resident, University of Alberta

Richard Wozniak M.Sc. Candidate, University of Alberta

Mary Hitt

M.Sc. Candidate, University of Alberta; Applications specialist in flow cytometry

David Evans Ph.D. Candidate, University of Alberta

Michael Hawkes M.D. student, University of Alberta

Katharine Magor Ph.D. Candidate, University of Alberta

Mary Hitt

B.Sc. Student Researcher, University of Alberta

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Hanne Ostergaard

THE LKSIOV 2017 ANNUAL REPORT

M.Sc. Candidate, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Trainees

Ulrike Strunk, Ph.D.

Brittany Umer

2011- 2017 (Ph.D. Candidate)

2014- present

Mentor:

Current Position:

Position:

Iryna Stryapunina

Ahmed Usman

2016- 2017

Mentor:

Position:

Ryan Stubbins

Ina Werninghaus

James Smiley Technician, Smiley Lab

Tom Hobman B.Sc. Student Researcher, University of Alberta

David Evans Ph.D. Candidate, University of Alberta

Edan Foley B.Sc. Student Researcher, University of Alberta

2015- 2017 (M.Sc. Candidate)

(University of Bonn)

Mentor:

2014- 2017

Jutta Preiksaitis Current Position:

Mentor:

Stephanie Yanow

Hematology Resident, University of British Columbia

Position:

Wilson Tat

Jason Wong

Mentor:

Position:

Brendan Todd

Zuoqiao (Joyce) Wu

2016- present

2012- present

Mentor:

Position:

2014- present

D Lorne Tyrrell M.Sc. Candidate, University of Alberta

Matthias Gรถtte Ph.D. Candidate, University of Alberta

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

B.Sc. Student Researcher 2011- present

Michael Houghton Ph.D. Candidate, University of Alberta

Robert Ingham Ph.D. Candidate, University of Alberta

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Yanna Xiao

Ran Zhuo, Ph.D.

2012- present

2014- present

Mentor:

Mentors:

Position:

Katharine Magor Ph.D. Candidate, University of Alberta

Xiaoli Lilly Pang and Bonita Lee Postdoctoral Fellow, University of Alberta

Zelei Yang 2016- present Mentor:

Denise Hemmings (co-supervisor) Position:

Ph.D. Candidate, University of Alberta

Shugang Yao 2012- present Mentor:

Hanne Ostergaard Position:

Ph.D. Candidate, University of Alberta

Wan Kong Yip 2013- present Mentor:

Maya Shmulevitz Position:

Ph.D. Candidate, University of Alberta

Kang Yu 2014- present Mentor:

Deborah Burshtyn Position:

Ph.D. Candidate, University of Alberta

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Staff

STAFF Name:

Year Joined: Position:

Laboratory:

Bill Addison, Ph.D.

1996

Research Associate

D.L. Tyrrell

Katharine Agopsowicz

2004

Research Technician

Hitt

Holly Bandi, M.Sc.

1998

Laboratory Manager

Smiley

Karyn Berry-Wynne

2012

Technician

D.L. Tyrrell

Leanne Bilawchuk

2012

Laboratory Manager

Marchant

Min Cao

2000

Research Technician

Pang

Eric Carpenter

2009

Computer Programmer

Wong

Anh Dang

1996

Laboratory Assistant

Hobman

Bianca Dauber, Ph.D.

2008

Research Associate

Smiley

Karen Deng

2013

Research Administrator

Wong

Megan Desaulniers

2014

Technician

Evans

Theodore Dos Santos

2017

Technician

Shmulevitz

Donna Douglas, Ph.D.

2001

Research Associate

Kneteman

Brenda Dugan

1985

Technologist

Bleakley

Heather Eaton, Ph.D.

2014

Technician

Burshtyn, Shmulevitz

Nancy Ehrman

1982

Technologist

Bleakley

Brittany Fraser

2014

Technician

Foley

Nicole Favis

2009

Technician

Evans

Nawall Fayad

2017

Research Assistant

Yanow

Karl Fischer

1988

Research Scientist

D.L Tyrrell

Ximena Fleming-Canepa

2007

Technician

Magor

Laura Henao-Caviedes

2017

Research Assistant

Baldwin, Foley

2011-2017

Research Associate

Wong

Michael Joyce, Ph.D.

1999

Research Scientist

D.L. Tyrrell

Gerald Lachance

1999

Technologist

D.L. Tyrrell

Juan Jovel, Ph.D.

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Suellen Lamb

2005

Histologist

D.L. Tyrrell

Aviad Levin, Ph.D.

2010

Research Associate

D.L. Tyrrell

Jamie Lewis

2003

Technician and Laboratory Manager

Kneteman

James Y.-C. Lin, Ph.D.

2016

Research Associate

Evans

Chen Liu

2015

Research Assistant

Pang

Darci Loewen-Dobler

2004

Support Staff

D.L. Tyrrell, Houghton

Valeria Mancinelli

2006

Technician

Hobman

Tracy Manning

2007

Laboratory Technician

Wong

Diane Marganski

1990

Technician

Bleakley

Tae Chul Moon, Ph.D.

2015

Research Associate

Barakat

Ryan Noyce, Ph.D.

2014

Research Associate

Evans

Sandra O’Keefe

2008

Laboratory Technician

Wong

Patrick Paszowski

2016

Technician

Ingham

Jordan Patterson

2010

Computer Programmer

Wong

Kristina Petkau

2013

Technician

Foley

Chris Pu

2010

Technician

Kneteman

Yuanyuan Qiu, Ph.D.

2014

Research Associate

Pang

Eileen Reklow

2003

Technician

Hobman

Deanna Santer, Ph.D.

2017

Research Associate

Houghton

Justin Shields

2009

Technician

D.L. Tyrrell

Rineke Steenbergen, Ph.D.

2008

Research Associate

D.L. Tyrrell

Ulrike Strunk, Ph.D.

2017

Technician

Smiley

Egor Tchesnokov, Ph.D.

2015

Research Associate

Götte

Ashley Wagner

2017

Technician

Shmulevitz

WeiWei Wang, Ph.D.

2013

Research Associate

Wong

Philip Winter

2007

Software Analyst

Tuszynski

Qingxia Yao, Ph.D.

2013

Research Associate

Gutfreund

Bing Zhang

2007

Technician

Baldwin

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Staff

JingXi (Cathy) Zhang Gang Zhou, Ph.D

2016-2017 2011

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Technician

Ingham

Research Associate

Kane

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FUNDING

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

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MAJOR INVESTMENTS The Li Ka Shing Institute of Virology was established on April 23, 2010 through combined gifts from the Li Ka Shing (Canada) Foundation and the Government of Alberta. The Endowment from the Li Ka Shing (Canada) Foundation has been fundamental for the establishment of this state-of-the-art virology institute that is currently home to some of the world’s best researchers in virology and virus-associated disease. This endowment also supports LKSIOV sponsorship of educational and academic activities (as detailed in the Sponsorship section). Institute of Virology (institute funding) discovery research and translation D Lorne Tyrrell (Director, PI) Li Ka Shing (Canada) Foundation (2010- 2020) $25,000,000 ($2.5 million per year for 10 years)

When the Li Ka Shing Institute of Virology was established, Mr. Li emphasized “the importance of translation of discoveries to products to benefit people”. At the same time, the Government of Alberta emphasized the importance of commercialization of discoveries to benefit the patients and the economy. The initial commitment for translational research was $50 million to double match the Li Ka Shing Foundation commitment. Grant to the Li Ka Shing Applied Virology Institute Michael Houghton (Director, PI) and D Lorne Tyrrell (Co-Director) Alberta Innovates Health Solutions (2013- 2019) $25,000,000 (2018- $5 million pending) (2019- 2023 $20 million pending)

The Li Ka Shing Applied Virology Institute (LSKAVI) has used artificial intelligence to design several molecules for specific therapeutic targets. The LKSAVI has filed patents in eight therapeutic areas and is working to bring three products to Phase I clinical trials in 2019 (Oncolytics, HCV Vaccine, and Group A Streptococcal Vaccine).

“The strength of a nation and its people depend on education and medical care. These are the country’s roots. And like a tree, the deeper its roots the more flourishing its branches and - Mr. Li Ka-Shing foliage” LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

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EXTERNAL FUNDING Li Ka Shing Institute of Virology members were successful in obtaining 33 awards from funding competitions held in 2017, earning a total of $20,587,236 in new funding (including $14,464,095 in CFI/CRC funding). In 2017, research in the Li Ka Shing Institute of Virology was supported by

$16,699,775 in member acquired grant or salary funding and $14,240,121 in CFI funding for a total of $30,939,896. The acquisition of this amount of funding for virus-related research activities highlights the quality and importance of the research programs developed by LKSIOV members and emphasizes the leadership of the Institute, the home Departments and Faculties, and the University of Alberta among Canadian research facilities.

Funded Projects 2017 Annual Amount from Selected Canadian Funding Sources: Canadian Institutes of Health Research (CIHR) Alberta Innovates (AI/ AITF/ AIHS) Natural Sciences and Engineering Research Council of Canada (NSERC) IC-Impacts Canadian Liver Foundation (CLF) Canadian Breast Cancer Foundation (CBCF) Women and Childrenâ&#x20AC;&#x2122;s Health Research Institute (WHCRI)

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$7,575,347 $6,778,295 $ 600,728 $ 401,230 $ 273,168 $ 249,798 $ 99,997

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Funding

Funding Awarded in 2017

Only Li Ka Shing Institute of Virology Members and their roles are indicated. Total values are given.

Infrastructure to support the discovery and development of innovative viroceuticals David Evans (Co-I) Canada Foundation for Innovation (CFI) (2017)

$5,831,531

Multi-scalar nanoscopy for advanced cell biology David Evans (Co-I) Canada Foundation for Innovation (CFI) (2017)

$7,672,564

Rapid multi-scale analyses for RNA profiling during viral infection David Evans (Co-I) Canada Foundation for Innovation (CFI) Infrastructure Grant (2017- 2018)

$460,000

Canadian Research Chair II in Molecular Virology and Oncotherapy Maya Shmulevitz (PI) Canadian Research Chairs (CRC) (2017- 2022)

$500,000

The role of CD71+ cells in HIV pathogenesis: reactivation of latent HIV by CD71+ cells and galectin-9 Michael Hawkes (Co-I) Canadian Institutes of Health Research (CIHR) (2017- 2018)

$166,667

Role of the HSV UL12.5 protein and host mitochondrial DNA in innate antiviral responses James Smiley (PI) Canadian Institutes for Health Research (CIHR) Project Grant (2017- 2019)

$267,750

Multimometer- vital signs device for diagnosis of pneumonia Michael Hawkes (Co-I)

Canadian Institutes of Health Research (CIHR) and Grand Challenges Canada (2017- 2019)

$112,000

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DRUM 2: First Nation and Métis communities working in partnership to develop integrated shared care models for HIV and other STBBI Karen Doucette (Co-I) Canadian Institutes for Health Research (CIHR) (2017- 2022)

$400,000

Solar powered oxygen delivery: transition to scale Michael Hawkes (PI)

Grand Challenges Canada Stars in Global Health, Phase 2 (2017- 2019) $500,000 (contingent on ELMA philanthropies)

Antiviral screening Tom Hobman (PI)

Public Works and Government Services Canada (Contract with Canadian Defense) (2017- 2018)

$159,710

Using advanced nanodelivery of micronutrients to enhance animal health Edan Foley (Co-PI) Natural Sciences and Engineering Research Council of Canada (NSERC) CDA (2017- 2019) $175,000 (Dr. Foley’s portion)

Role of RasGRP1 in regulating lymphocyte development and function Troy Baldwin (PI) Natural Sciences and Engineering Research Council of Canada (NSERC) (2017- 2022)

$130,000

DBL protein function in P. chabaudi invasion and cytoadhesion Stephanie Yanow (PI)

Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (2017- 2022)

$130,000

Elucidating the molecular mechanisms of signalling pathways Robert Ingham (PI)

Natural Sciences and Engineering Research Council of Canada (NSERC) (2017- 2022)

$130,000

The effect of cyclophilins on the early steps of HBV replication D Lorne Tyrrell (PI) ContraVir (2017- 2018)

$122,334

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Funding

Canadian network for autoimmune liver disease- registry for Canadian patients with primary biliary cholangitis and autoimmune hepatitis Andrew Mason (PI)

Canadian Liver Foundation and Intercept Pharmaceuticals- Practice to Policy Awards Program (2017- 2020) $645,000 (USD)

Cytomegalovirus (CMV) vaccine development: a study of viral tropism, genomic diversity and neutralizing epitopes in CMV positive clinical samples Jutta Preiksaitis (PI); Karen Doucette and Xiaoli (Lilly) Pang (Co-Is) Alberta Innovates/ Pfizer Canada Translational Research Program (2017- 2018)

$394,970

Quantum entanglement in the brain and the physics of consciousness Jack Tuszynski (Co-I) Alberta Innovates Technology Futures (AITF) (2017- 2018)

$5,000

Improving government service and management of Alberta’s water resources through a comprehensive approach to microbiological water quality analysis Xiaoli (Lilly) Pang (PI) Alberta Health (2017- 2020)

$387,020

Oligomerization inhibitors for α-synuclein screened by an integrated computational/ experimental platform Jack Tuszynski (Co-I) Alberta Prion Research Institute Explorations Program (2017- 2020)

$398,000

Targeting the blood-brain barrier through VEGFR2 to improve outcomes in cerebral malaria Michael Hawkes (PI) Women and Children’s Health Research Institute (WCHRI) Innovation Grant (2017- 2019)

$49,994

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Combination of a novel TRAIL-expressing oncolytic virus with a caspase-3 activator for treatment of ovarian cancer Mary Hitt (PI); David Evans (Co-I) Women and Children’s Health Research Institute (WCHRI) Innovation Grant (2017- 2019)

$50,000

The relationship of bioactive lysophospholipids to adiponectin in normal and adverse pregnancies Denise Hemmings (PI) Women and Children’s Health Research Institute (WCHRI) (2017- 2019)

$50,000

Hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) in Canada Karen Doucette (National Co-I; Site PI) Calgary Centre for Clinical Research (CCR) (2017)

$254,558

Oncolytic vaccinia virus for bladder cancer treatment: a phase I/ II trial David Evans (PI); Mary Hitt (Co-I) BioCanRx Network Centre of Excellence Enabling Studies Program (2017- 2018)

$226,054

Combination of a novel TRAIL-expressing oncolytic virus with a caspase-3 activator for treatment of ovarian cancer Mary Hitt (PI); David Evans (Co-I) Granulosa Cell Tumor Research Foundation (2017- 2019) $20,000 (USD)

Exploring and exploiting proteases in breast cancer microenvironments to enhance the potency of reovirus oncolysis Maya Shmulevitz (PI) Cancer Research Society (2017- 2019)

$120,000

Electromagnetically-mediated energy transduction in the cytoskeleton Jack Tuszynski (Co-I) Defense Advanced Research Projects Agency (DARPA) subcontract (2017- 2021) $400,000 (USD)

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Funding

Studies on tissues recovered from experimental mice D Lorne Tyrrell (Co-PI) National Institutes of Health Research (NIH) (2017- 2018)

$17,158

A point-of-care device for malaria diagnosis and drug resistance genotyping Stephanie Yanow (PI) IC-Impacts (2017- 2018)

$267,900

Effects of low-intensity magnetic fields on sub-cellular structures Jack Tuszynski (PI) Nativis Inc. Sponsored Research (2017- 2018) $66,000 (USD)

Fecal microbial transplantation and prebiotic supplementation in subjects with obesity and metabolic syndrome Gane Ka-Shu Wong (Co-I) Weston Family Microbiome Initiative, Catalyst for Translation (2017- 2019)

$149,535

Chemical synthesis of a lead compound Jack Tuszynski (PI)

Private donation from the Allard Foundation (2017)

$22,500

Continued Funding Facility for functional genomic analysis of oncolytic viruses Maya Shmulevitz (PI) Canadian Foundation for Innovation (CFI) Grant (2012- 2017)

$357,104

Innate and adaptive killer lymphocyte responses Kevin Kane (PI) Canadian Foundation for Innovation (CFI) Grant (2013- 2018)

$1,023,024

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Canadian Research Chair I in Molecular Virology James Smiley (PI) Canadian Research Chairs (CRC) (2004- 2018)

$2,800,000

Viral hepatitis & inflammatory disease Michael Houghton

Canadian Institutes of Health Research (CIHR) Canada Excellence Research Chair (CERC) in Virology (2010- 2018)

$10,000,000

Sphingosine 1-phosphate: a double-edged sword regulating vascular tone in pregnancy Denise Hemmings (PI) Canadian Institutes of Health Research (CIHR) (2012- 2018)

$770,538

Leukocyte Ig-like receptor-B1 regulation and function Deborah Burshtyn (PI) Canadian Institutes of Health Research (CIHR) (2012- 2018)

$623,000

Studies on hepatitis C- host pathogen interactions D Lorne Tyrrell (PI) Canadian Institutes of Health Research (CIHR) (2013- 2018)

$612,030

Towards a transformative understanding of HAND Tom Hobman (Co-PI)

Canadian Institutes of Health Research (CIHR) Team Grant (2013- 2018)

$2,500,000

Flavivirus host interactions Tom Hobman (PI)

Canadian Institutes of Health Research (CIHR) Operating Grant (2013- 2018)

$905,000

Molecular mechanisms involved in resistance to different classes of HIV RT inhibitors Matthias Gรถtte (PI) Canadian Institutes of Health Research (CIHR) Operating Grant (2013- 2018)

$665,000

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Funding

Interactions between components of the HCV replication complex Matthias Gรถtte (PI) Canadian Institutes of Health Research (CIHR) Operating Grant (2013- 2018)

$684,000

The development of safer oncolytic poxviruses dependent on cellular dNTP synthesis David Evans (PI); Mary Hitt (Co-I) Canadian Institutes of Health Research (CIHR) Operating Grant (2013- 2018)

$748,558

Cellular and molecular regulation of T cell tolerance Troy Baldwin (PI)

Canadian Institutes of Health Research (CIHR) Operating Grant (2013- 2018)

$784,330

Characterizing structural changes that retarget enteric reovirus towards tumours Maya Shmulevitz (PI) Canadian Institutes of Health Research (CIHR) (2013- 2018)

$563,670

Role of the nuclear pore complex in genome organization and gene silencing Richard Wozniak (PI) Canadian Institutes of Health Research (CIHR) Operating Grant (2013- 2018)

$719,630

Canadian national transplant research program Andrew Mason (Co-I)

Canadian Institutes of Health Research (CIHR) and Canadian Liver Foundation (CLF) Team Grant (2013- 2018)

$300,000

Poxvirus control of ubiquitination Robert Ingham (PI)

Canadian Institutes of Health Research (CIHR) (2013- 2019)

$604,000

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Contribution of the cytoskeletal adaptor proteins paxillin and leupaxin to cytotoxic T cell migration and function Hanne Ostergaard (PI) Canadian Institutes of Health Research (CIHR) (2014- 2019)

$682,395

Pediatric HIV infection: exploring determinants of a functional cure Michael Hawkes (Co-PI)

Canadian Institutes of Health Research (CIHR) Subvention d’équipe: initiative Canadienne pour recherché sur un remède contre le VIH (2014- 2019)

$1,775,000

Pathogen specific effectiveness of probiotics in children with acute gastroenteritis Xiaoli (Lilly) Pang, Bonita Lee (Co-Is) Canadian Institutes of Health Research (CIHR) Operating Grant (2014- 2019)

$84,972

Lymphocyte proteinases Chris Bleackley (PI)

Canadian Institutes of Health Research (CIHR) Operating Grant (2014- 2019)

$1,003,550

Role of western-style diet-induced changes in gut microbiota and immune function in the development of colitis Gane Ka-Shu Wong (Co-I) Canadian Institutes of Health Research (CIHR) Operating Grant (2014- 2019)

$581,799

Receptors and signalling David Marchant (PI)

Canadian Institutes of Health Research (CIHR) Operating Grant (2014- 2019)

$453,000

Translational studies to test potential therapies for patients with primary biliary cirrhosis Andrew Mason (PI); Jack Tuszynski (Co-PI) Canadian Institutes of Health Research (CIHR) (2014- 2019)

$768,060

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Funding

Characterization of molecular events controlling nuclear envelope/ chromatin interaction Richard Wozniak (PI) Canadian Institutes of Health Research (CIHR) Operating Grant (2015- 2020)

$724,550

Delineation of the molecular and physiological relationships between intestinal epithelial defenses and insulin responses in the model organism Drosophila melanogaster Edan Foley (PI) Canadian Institutes of Health Research (CIHR) Operating Grant (2015- 2020)

$670,000

Canadian network on hepatitis C (CanHepC) Andrew Mason, Michael Houghton, D. Lorne Tyrrell, Norman Kneteman (Co-Is) Canadian Institutes of Health Research (CIHR) Network Grant (2015- 2020)

$4,500,000

Molecular basis for Zika virus pathogenesis Tom Hobman (PI)

Canadian Institutes of Health Research (CIHR) Team Grant (2016- 2019)

$499,953

IMAGINE: inflammation, microbiome, and alimentation: gastro-intestinal and neuropsychiatric effects Andrew Mason (Co-I); Gane Ka-Shu Wong (collaborator)

Canadian Institutes of Health Research (CIHR) Strategy for Patient-Oriented Research SPOR (2016- 2021)

$12,450,000

Zika virus biology, diagnostics and therapeutic approaches Tom Hobman (PI) Canadian Institutes of Health Research (CIHR) Project Grant (2016- 2021)

$1,020,610

Membrane biology training program Tom Hobman (Co-PI)

Natural Sciences and Engineering Research Council of Canada (NSERC) CREATE (2012- 2018)

$1,640,796

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Immunogenetics of antiviral immunity in ducks Katharine Magor (PI)

Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (2015- 2020)

$225,000

Atomistic computational models to evaluate protein-ligand off-target interactions Khaled Barakat (PI) Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (2015- 2021)

$150,000

The MoEDAL experiment at the large hadron collider Jack Tuszynski

Natural Sciences and Engineering Research Council of Canada (NSERC) (2016- 2018)

$87,500

Urban stormwater and municipal effluents: innovative solutions for source water Xiaoli (Lilly) Pang (Co-I) Natural Sciences and Engineering Research Council of Canada (NSERC) Operating Grant (2016- 2019)

$57,037

Determinants of natural killer cell Ly49 receptor specificity Kevin Kane (PI)

Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (2016- 2021)

$145,000

Relationship between cytomegalovirus infection and breast tumor growth, metastasis and treatment efficacy Denise Hemmings (Co-PI) Canadian Breast Cancer Foundation (CBCF)- Prairies/ NWT (2015- 2018)

$374,877

Modulating activity of Ago2 in breast cancer: a novel tumor suppressor? Tom Hobman (PI) Canadian Breast Cancer Foundation (CBCF) (2015- 2018)

$374,517

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Funding

Multiple evidence reviews for PHAC Karen Doucette (Co-I)

Public Health Agency of Canada (PHAC) & Nova Scotia Health Research Foundation (2015)

$200,000

Ligand recognition by Ly49 NK cell receptors Kevin Kane (PI)

Canadian Association of University Teachers Operating Grant (2015- 2018)

$29,422

Pathobiont discovery in pediatric IBD Gane Ka-Shu Wong (Co-I)

Crohn’s and Colitis Canada, Crohn’s and Colitis Foundation of America, Grant-in-Aid of Research (2015- 2018)

$375,000

Development of a vaccine against the hepatitis C virus (HCV) and demonstration of efficacy in intravenous drug users D Lorne Tyrrell (PI) Alberta Health Services (2013- 2020)

$50,000

Biosystems informatics Gane Ka-Shu Wong (PI)

Alberta Innovates Technology Futures, iCORE Strategic Chair (2013- 2018)

$5,000,000

Development of a vaccine against the hepatitis C virus (HCV) and demonstration of efficacy in intravenous drug users Michael Houghton and D Lorne Tyrrell (Co-PIs)

Alberta Innovates Health Solutions Collaborative Research & Innovation Opportunities (2013- 2018)

$5,000,000

Assessing water quality, microbial risks and waterborne pathogens in rural Alberta Xiaoli (Lilly) Pang (Co-PI); Bonita Lee (Co-I) Alberta Innovates Operating Grant (2014- 2018)

$441,430

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Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE): epidemiology, emerging organisms, and economics Xiaoli (Lilly) Pang and Bonita Lee (Co-leaders) Alberta Innovates CRIO Program Operating Grant (2014- 2020)

$1,797,744

Novel therapeutic strategies for unresectable lung cancer based on targeting DNA repair Jack Tuszynski (Co-I) Alberta Cancer Foundation (ACF) Transformative Program (2015- 2018)

$3,000,000

Developing novel cancer immunotherapy drugs: a multidisciplinary team Khaled Barakat (PI); Michael Houghton, D Lorne Tyrrell, and Mary Hitt (Co-Is)

Alberta Cancer Foundation (ACF) Transformative Program Investment and Li Ka Shing Institute of Applied Virology (LKSIAV) Grant (2015- 2021)

$5,386,000

The impact of placental overexpression of vasoactive peptides on fetal cardiac form and function: exploring a novel link between placental function and cardiac development in an in vivo murine model Denise Hemmings (Co-PI) Women and Childrenâ&#x20AC;&#x2122;s Health Research Institute (WCHRI) (2016- 2018)

$50,000

Parasitic helminths: from livestock to global human health. Infections, inflammation and chronic diseases research strategy Michael Hawkes (Co-I) University of Calgary Vice-President Research Initiative (2016- 2018)

$200,000

Identification of high-affinity ligands to Dengue virus NS1 for point of care diagnostics Tom Hobman (PI); Khaled Barakat (Co-I) IC-Impacts Centres of Excellence (2015- 2018) $400,000 (USD)

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Funding

Infeccion gestacional por Plasmodium vivax: inmunopatogenesis, histopatologia y genetica plasmodial, y sus efectos en la morbimortalidad maternal, fetal y neonatal en el noroccidente de Colombia, 2016-2018 Stephanie Yanow (collaborator) Universidad de Antioquia (Columbia) Project Grant (2015- 2018)

$106,500

$82,700

Inmunopatología, epidemiología y clínica de las malarias gestacional y placentaria por Plasmodium vivax; Colombia Stephanie Yanow (collaborator) Universidad de Antioquia (Columbia) (2015- 2018)

$50,000

A study to determine the epidemiology and disease burden of chronic hepatitis B in Canada Karen Doucette (National Co-I; Site PI) Gilead Sciences, Inc. (2016)

$381,353

The development of a database of ion channels with their modulators for cellular electrophysiology modeling Jack Tuszynski (Co-PI) Paul G Allen Foundation Subgrant (2016- 2018)

$115,000

The role of various molecular sub-cellular structures in the response to TTFields Jack Tuszynski (Co-I) Novocure Ltd. (2016- 2018) $150,000 (USD)

Understanding the genetics of hepatic copper toxicosis in the Dalmatian Andrew Mason (PI) American Kennel Club; Canine Health Foundation (2016- 2018)

$100,000

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PBC analysis of responders versus non-responders to Obeticholic Acidgenetic studies Andrew Mason (PI) Intercept Pharmaceuticals (2016- 2018) $390,000 (USD)

An objective instrument for respiratory rate measurement in children in resource-limited settings: the RespimometerÂŽ Michael Hawkes (Co-I) USAID (2016- 2018)

$250,000

1000 Plants Gane Ka-Shu Wong (PI)

Somekh Family Foundation, Charitable Donation (2011- 2021)

$482,990

Studies to develop improved treatment for patients suffering cancer and also to support basic research intended to evaluate the ability of the KMT mouse model as a model of cancer therapy Norman Kneteman (PI) Ida Hoffman (Endowment Fund) (2003- )

$24,455 / yr

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KNOWLEDGE TRANSFER

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Publications

LI KA SHING INSTITUTE OF VIROLOGY MEMBERS HAD A PRODUCTIVE 2017! Research activities within the Institute resulted in: 129 Peer-Reviewed Manuscripts 5 Book Chapters 141 Abstracts 60 International meetings 81 National meetings 87 Invited Presentations by 27 LKSIOV Principal Investigators 9 Patents 2 Spin-Off Companies 9 T.V./ Radio Interviews 8 News Articles 1 Podcast

COLLABORATION WITHIN THE INSTITUTE:

26 Peer-Reviewed Manuscripts and 37 Abstracts were authored by two or more

Li Ka Shing Institute of Virology Principal Investigators

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PUBLICATIONS

Li Ka Shing Institute of Virology Principal Investigators in Bold Ablenas CJ, Liu HW, Shkriabai N, Kvaratskhelia M, Cosa G, Götte M.

The too many faces of PD-L1: a comprehensive conformational analysis study. Biochemistry. 2017; 56 (40): 5428-5439. Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K.

Modelling the human Nav1.5 sodium channel: structural and mechanistic insights of ion Dynamic interconversions of HCV helicase binding permeation and drug blockade. modes on the nucleic acid substrate. Drug Des Devel Ther. 2017; 11: 2301-2324. ACS Infect Dis. 2017; 3 (1): 99-109. Alberts R, de Vries EMG, Goode EC, Jiang X, Abrignani S, Neddermann P, Houghton M, Sampaziotis F, Rombouts K, Böttcher K, Folseraas deFrancesco R. T, Weismüller TJ, Mason AL, Want W, Alexander G, Hepatitis C vaccines. Alvaro D, Bergquist A, Björkström NK, Beuers U, Plotkin S, Orenstein W et al. editors. Plotkin’s Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Vaccines. Elsevier Science Publishers 2017; 375Carbone M, Chazouillères O, Cheung A, Dalekos G, 386. Eaton J, Eksteen B, Ellinghaus D, Färkkilä M, Festen EAM, Floreani A, Franceschet I, Gotthardt DN, Acharya B, Aleandre J, Baines S, Benes P, Hirschfield GM, Hoek BV, Holm K, Hohenester S, Bergmann B, Bernabéu J, Branzas H, Campbell M, Hov JR, Imhann F, Invernizi P, Juan BD, Lenzen H, Caramete L, Cecchini S, de Montigny M, De Roeck Lieb W, Liu JZ, Marschall HU, Marzioni M, Melum A, Ellis JR, Fairbairn M, Felea D, Flores J, Frank M, E, Milkiewicz P, Müller T, Pares A, Rupp C, Rust C, Frekers D, Garcia C, Hirt AM, Janecek J, Kalliokoski Sandford RN, Schramm C, Schreiber S, Schrumpf E, M, Katre A, Kim DW, Kinoshita K, Korzenev A, Silverberg MS, Srivastava B, Sterneck M, Teufel A, Lacarrère DH, Lee SC, Leroy C, Lionti A, Mamuzic J, Vallier L, Verheij J, Vila AV, Vries B, Zachou K, Margiotta A, Mauri N, Mavromatos NE, Mermod P, International PSC Study Group, The UK PSC Mitsou VA, Orava R, Parker B, Pasqualini L, Patrizii Consortium, Chapman RW, Manns MP, Pinzani M, L, Păvălaş GE, Pinfold JL, Popa V, Pozzato M, Rushbrook SM, Lazaridis KN, Franke A, Anderson Pospisil S, Rajantie A, Ruiz de Austri R, Sahnoun Z, CA, Karlsen TH, Ponsioen CY, Weersma RK. Sakellariadou M, Sakar S, Semenoff G, Shaa A, Sirri G, Sliwa K, Soluk R, Spurio M, Srivastava YN, Suk M, Genetic association analysis identifies variants associated with disease progression in primary Swain J, Tenti M, Togo V, Tuszynski JA, Vento V, sclerosing cholangitis. Vives O, Vykydal Z, Whyntie T, Widom A, Willems Gut. 2017; pii: gutjnl-2016-313598. G, Yoon JH, Zgura IS; MoEDAL Collaboration. Search for magnetic monopoles with the MoEDAL forward trapping detector in 13 TeV protonproton collisions at the LHC. Phys Rev Lett. 2017; 118 (6): 061801. Ahmed M, Barakat K. When theory meets experiment: the PD-1 challenge. J Mol Model. 2017; 23 (11): 308. Ahmed M, Barakat K.

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Arroyo-Arroyo M, Arango E, Carmona-Fonseca J, Aristizabal B, Yanow S, Maestre A. Efficacy of different primaquine regimens to control Plasmodium falciparum gametocytemiain Columbia. Am J Trop Med Hyg. 2017; 97 (3): 712-718. Atherton MJ, Evgin L, Keller BA, Shenouda MM, Stephenson KB, Vile RG, Bell JC, Evans DH. Infectious optimism following the 10th international oncolytic virus meeting.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Publications

Mol Therapeutics: Oncolytics. 2017; 7: 12-16.

Viruses. 2017; 9 (8): pii: e207.

Ayoub AT, Staelens M, Prunotto A, Deriu MA, Danani A, Klobukowsi M, Tuszynski JA.

Blythell-Douglas R, Rothfels CJ, Stevenson DWD, Graham SW, Wong GK, Nelson DC, Bennett T.

Explaining the microtubule energy balance: contributions due to dipole moments, charges, van der Waals and solvation energy. Int J Mol Sci. 2017; 18 (10): e2042.

Evolution of strigolactone receptors by gradual neo-functionalization of KAI2 paralogues. BMC Biol. 2017; 15 (1): 52.

Balzarini J, Menni M, Das K, van Berckelaer L, Ford A, Maguire NM, Liekens S, Boehmer PE, Arnold E, Götte M, Maguire AR. Guanine α-carboxy nucleoside phosphonate (G-αCNP) shows different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses. Biochem Pharmacol. 2017; 136: 51-61. Barakat K, Houghton M, Tyrrell DL, Tuszynski JA. Rational drug design rational drug design: one target, many paths to it. Pharmaceutical Sciences: Breakthroughs in Research and Practice. 2017 doi: 10.418/978-15225-1762-7.ch044. Barker KR, Lu Z, Kim H, Zheng Y, Chen J, Conroy AL, Hawkes M, Cheng HS, Njock MS, Fish JE, Harlan JM, López JA, Liles WC, Kain KC. miR-155 modifies inflammation, endothelial activation and blood-brain barrier dysfunction in cerebral malaria. Mol Med. 2017; 23: doi: 10.2119/molmed.2016.00139. Barzanjeh S, Salari V, Tuszynski JA, Cifra M, Simon C. An optomechanical proposal for monitoring microtubule mechanical vibrations. Phys Rev E. 2017; 96 (1-1): 012404. Bilawchuk LM, Griffiths CD, Jensen LD, Elawar F, Marchant DJ.

Bral M, Gala-Lopez B, Bigam D, Kneteman N, Malcolm A, Livingstone S, Andres A, Emamuallee J, Russell L, Cousios C, West LJ, Friend PJ, Shapiro AM. Single-center Canadian experience of human normothermic ex vivo liver perfusion: results of a clinical trial. Am J Transplant. 2017; 17 (4): 1071-1080. Brooks HM, Hawkes MT. Repurposing pharmaceuticals as neuroprotective agents for cerebral malaria. Curr Clin Pharmacol. 2017; doi: 10.2174/1574884712666170704144042. Brooks HM, Jean Paul MK, Claude KM, Houston S, Hawkes MT. Malaria in an internally displaced persons camp in the Democratic Republic of the Congo. Clin Infect Dis. 2017; 65 (3): 529-530. Brooks HM, Jean Paul MK, Claude KM, Mocanu V, Hawkes MT. Use and disuse of malaria bed nets in an internally displaced persons camp in the Democratic Republic of the Congo: a mixedmethods study. PLoS One. 2017; 12 (9): e0185290. Cao AT, Mackova M, Kerage D, Brindley DN, Hemmings DG. Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3. Exp Gerontol. 2017; 99: 87-97.

The susceptibility of respiratory syncytial virus to nucleolin receptor blocking and antibody Capitanio JS, Montpetit B, Wozniak RW. neutralization are dependent upon the method of Human Nup98 regulates the localization and virus purification. activity of DExH/D-box helicase DHX9.

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Elife. 2017; 6: pii: e18825.

Scientific Reports. 2017; 7: 9877.

Cervera C, Sanroma P, Gonzàlez-Ramallo V, García de la María C, Sanclemente G, Sopena N, Pajarón M, Segado A, Mirón M, Antón F, Basterretxea A, Cuende A, Miró JM; DAPTODOM Investigators.

Deriu MA, Cangiotti M, Grasso G, Licandro G, Lavasanifar A, Tuszynski JA, Ottaviani MF, Danani A.

Safety and efficacy of daptomycin in outpatient parenteral antimicrobial therapy: a prospective and multicenter cohort study (DAPTODOM trial). Infect Dis (Lond). 2017; 49 (3): 200-207. Chan MCW, Hu Y, Chen H, Podkolzin AT, Zaytseva EV, Komano J, Sakon N, Poovorawan Y, Vongpunsawad S, Thanusuwannasak T, Hewitt J, Croucher D, Collins N, Vinjé J, Pang XL, Lee BE, de Graaf M, van Beek J, Vennema H, Koopmans MPG, Niendorf S, Poljsak-Prijatelj M, Steyer A, White PA, Lun JH, Mans J, Hung TN, Kwok K, Cheung K, Lee N, Chan PKS. Global spread of norovirus GII.17 Kawasaki 308, 2014-2016. Emerg Infect Dis. 2017; 23 (8): 1359-1354. Cocchi M, Bernroider G, Rasenick M, Tonello L, Gabrielli F, Tuszynski JA. Document of Trapani on animal consciousness and quantum brain function: a hypothesis. J Integr Neurosci. 2017; 16 (s1): S99-S103. Cocchi M, Gabrielli F, Tonello L, Tuszynski J. A dialogue on the issue of the “quantum brain” between consciousness and unconsciousness. J Integr Neurosci. 2017; 16 (s1): S13-S18. Cocchi M, Minuto C, Tonello L, Gabrielli F, Bernroider G, Tuszynski JA, Cappello F, Rasenick M. Linoleic acid: is this the key that unlocks the quantum brain? BMC Neurosci. 2017; 18 (1): 38. Craddock TJA, Kurian P, Preto J, Sahu K, Hameroff SR, Klobukowski M, Tuszynski JA. Anesthetic alterations of collective terahertz oscillations in tubulin correlates with clinical potency: implications for anesthetic action and post-operative cognitive dysfunction.

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Self-assembled ligands targeting TLR-7; a molecular level investigation. Langmuir. 2017; 33 (50): 14460-14471. Ding N, Craik SA, Pang X, Lee B, Neumann NF. Assessing UV inactivation of adenovirus 41 using integrated cell culture real-time qPCR/RT-qPCR. Water Environ Res. 2017; 89 (4): 323-329. Dong M, Artusa P, Kelly SA, Fournier M, Baldwin TA, Mandl JN, Melichar HJ. Alterations in the thymic selection threshold skew the self-reactivity of the TCR repertoire in neonates. J Immunol. 2017; 199 (3): 965-973. Doucette KE and Fishman JA. Infections in the immunocompromised host. Civetta, Taylor and Kirby’s editors. Critical Care, 5th Edition (chapter 110). Lippincott Williams & Wilkins. 2017; 1112-23. Eaton H, Dermody T, Johnston R, Jais P, Shmulevitz M. African swine fever virus NP868R capping enzyme promotes reovirus rescue during reverse genetics by promoting reovirus protein expression, virion assembly, and RNA incorporation into infectious virions. J Virol. 2017; 91 (11): pii: e02416-16. Elawar F, Griffiths CD, Zhu D, Bilawchuk M, Jensen LD, Forss L, Tang J, Hazes B, Drews SJ, Marchant DJ. A virological and phylogenetic analysis of the emergence of new clades of respiratory syncytial virus. Sci Rep. 2017; 7 (1): 12232. Eyre NS, Aloia AL, Joyce MA, Chulanetra M, Tyrrell DL, Beard MR.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Publications

Sensitive luminescent reporter viruses reveal appreciable release of hepatitis C virus N5A protein into the extracellular environment. Virology. 2017; 507: 20-31. Freedman SB, Eltorki M, Chui L, Xie J, Feng S, MacDonald J, Dixon A, Ali S, Louie M, Lee BE, Osterreicher L, Thull-Freedman J. Province-wide review of pediatric Shiga toxinproducing Escherichia coli case management. J Pediatr. 2017; 180: 184-190. Freedman H, Logan MR, Hockman D, Koehler Leman J, Law JL, Houghton M.

Traceable PEO-poly(ester) micelles for breast cancer targeting: The effect of core structure and targeting peptide on micellar tumor accumulation. Biomaterials. 2017;144: 17-29. Gavina K, Arango E, Alvarez Larrotta C, Maestre A, Yanow SK. A sensitive species-specific reverse transcription real-time PCR method for detection of Plasmodium falciparum and Plasmodium vivax. Parasite Epidemiology and Control. 2017; 2 (2): 7076.

Computational prediction of the heterodimeric Gentile F, Tuszynski JA, Barakat KH. and higher order structure of gpE1/gpE2 envelope glycoproteins encoded by hepatitis C virus. Commentary: New design of nucleotide excision J Virol. 2017; 91 (8): pii: e02309-16. repair (NER) inhibitors for combination cancer therapy. Freedman SB, Xie J, Nettel-Aguirre A, Lee B, Chui L, Journal of Cancer Treatment & Diagnosis. 2017; 1 Pang XL, Zhuo R, Parsons B, Dickinson JA, (1): 1-3. Vanderkooi OG, Ali S, Osterreicher L, Lowerison K, Tarr PI; APPETITE. Ghaly PE, Churchill CDM, Abou El-Magd RM, Hájková Z, Dráber P, West FG, Tuszynski JA. Enteropathogen detection in children with diarrhoea, or vomiting, or both, comparing rectal Synthesis and biological evaluation of structurally flocked swabs with stool specimens: an simplified noscapine analogues as microtubule outpatient cohort study. binding agents. Lancet Gastroenterol Hepatol. 2017; 2 (9): 662Can J Chem. 2017; 95 (6): 649-655. 669. Gidi Y, Götte M, Cosa G. Ganesan A, Barakat K. Conformational changes spanning angstroms to Applications of computer-aided approaches in the nanometers via a combined protein-induced fluorescence enhancement-förster resonance development of hepatitis C antiviral agents. energy transfer method. Expert Opin Drug Discov. 2017; 12 (4): 407-425. J Phys Chem B. 2017; 121 (9): 2039-2048. Ganesan A, Coote ML, Barakat K. Golec DP, Hoeppli RE, Henao Caviedes LM, McCann Molecular dynamics-driven drug discovery: J, Levings MK, Baldwin TA. leaping forward with confidence. Thymic progenitors of TCRαβ+ CD8αα intestinal Drug Discov Today. 2017; 22 (2): 249-269. intraepithelial lymphocytes require RasGRP1 for Ganesan A, Coote ML, Barakat K. development. Molecular ‘time-machines’ to unravel key J Exp Med. 2017; 214 (8): 2421-2435. biological events for drug design. Govorunova EG, Sineshchekov OA, Rodarte EM, WIREs Comput Mol Sci. 2017; 7: e1306. Janz R, Morelle O, Melkonian M, Wong GK, Garg SM, Paiva IM, Vakili MR, Soudy R, Agopsowicz Spudich JL. K, Soleimani AH, Hitt M, Kaur K, Lavasanifar A.

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The expanding family of natural anion channelrhodopsins reveals large variations in kinetics, conductance, and spectral sensitivity. Sci Rep. 2017; 7: 43358. Grasso G, Tuszynski JA, Morbiducci U, Licandro G, Danani A, Deriu MA. Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamics. Biol Direct. 2017; 12 (1): 2. Griffiths C, Drews SJ, Marchant DJ. Respiratory syncytial virus infection, detection and new options for prevention and treatment. Clin Microbiol Rev. 2017; 30 (1): 277-319. Gudiol C, Royo-Cebrecos C, Abdala E, Akova M, Álvarez R, Maestro-de la Calle G, Cano A, Cervera C, Clemente WT, Martín-Dávila P, Freifeld A, Gómez L, Gottlieb T, Gurguí M, Herrera F, Manzur A, Maschmeyer G, Meije Y, Montejo M, Peghin M, Rodríguez-Baño J, Ruiz-Camps I, Sukiennik TC, Tebe C, Carratalà J; BICAR Study Group. Efficacy of β-lactam/ β-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum-β-lactamaseproducing Enterobacteriaceae in hematological patients with neutropenia. Antimicrob Agents Chemother. 2017; 61 (8): e00164-17. Gudiol C, Royo-Cebrecos C, Tebe C, Abdala E, Akova M, Álvarez R, Maestro-de la Calle G, Cano A, Cervera C, Clemente WT, Martín-Dávila P, Freifeld A, Gómez L, Gottlieb T, Gurguí M, Herrera F, Manzur A, Maschmeyer G, Meije Y, Montejo M, Peghin M, Rodríguez-Baño J, Ruiz-Camps I, Sukiennik TC, Carratalà J; BICAR study group. Clinical efficacy of β-lactam/ β-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum β-lactamase-producing Enterobacteriaceae in haematological patients with neutropaenia: a study protocol for a retrospective observational study (BICAR).

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BMJ Open. 2017; 7 (1): e013268. Hackenberg D, McKain MR, Lee SG, Roy Choudhury S, McCann T, Schreier S, Harkess A, Pires JC, Wong GK, Jez JM, Kellogg EA, Pandey S. Gα and regulator of G-protein signaling (RGS) protein pairs maintain functional compatibility and conserved interaction interfaces throughout evolution despite frequent loss of RGS protein in plants. New Phytol. 2017; 216 (2): 562-575. Han JD, Li X, Jiang CK, Wong GK, Rothfels CJ, Rao GY. Evolutionary analysis of the LAFL genes involved in the land plant seed maturation program. Front Plant Sci. 2017; 8: 439. He T, McMillen TA, Qiu Y, Chen LH, Lu X, Pang XL, Kamboj M, Tang YW. Norovirus loads in stool specimens of cancer patients with norovirus gastroenteritis. J Mol Diagn. 2017; 19 (6): 836-842. Hou S*, Kumar A*, Xu Z, Airo AM, Stryapunina I, Wong CP, Branton W, Tchesnokov E, Götte M, Power C, Hobman TC. Zika virus hijacks stress granule proteins and modulates the host stress response. J Virol. 2017; 91(16): e00474-17. *authors contributed equally. Hu QN, Suen AYW, Henao Caviedes LM, Baldwin TA. Nur77 regulates nondeletional mechanisms of tolerance in T cells. J Immunol. 2017; 199 (9): 3147-3157. Irwin CR, Hitt MM, Evans DH. Targeting nucleotide biosynthesis: a strategy for improving the oncolytic potential of DNA viruses. Front Oncol. 2017; 7: 229. DOI: 10.3389/fonc.2017.00229. Jalily Hasani H, Ahmed M, Barakat K.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Publications

A comprehensive structural model for the human Kcnq1/Kcne1 ion channel. J Mol Graph Model. 2017; 78: 26-47. Jalily Hasani H, Barakat K. Homology modelling: an overview of fundamentals and tools. International Review on Modelling and Simulations (IREMOS). 2017; 10 (2). Johnson KL, Cassin AM, Lonsdale A, Wong GK, Soltis DE, Miles NW, Melkonian M, Melkonian B, Deyholos MK, Leebens-Mack J, Rothfels CJ, Stevenson DW, Graham SW, Wang X, Wu S, Pires JC, Edger PP, Carpenter EJ, Bacic A, Doblin MS, Schultz CJ. Insights into the evolution of hydroxyproline-rich glycoproteins from 1000 plant transcriptomes. Plant Physiol. 2017; 174 (2): 904-921. Jovel J, Dieleman A, Koa D, Mason A, Wine E. The human gut microbiome. Nagarjan M ed. Chapter 10 in Metagenomics: Perspectives, Methods and Applications. Elselvier Press. 2017. Jovel J, O’keefe S, Patterson J, Bording-Jorgensen M, Wang W, Mason AL, Warren KG, Wong GK. Cerebrospinal fluid in a small cohort of patients with multiple sclerosis was generally free of microbial DNA. Front Cell Infect Microbiol. 2017; 6: 198. Kalyaanamoorthy S, Barakat KH. Binding modes of hERG blockers: an unsolved mystery in the drug design arena. Expert Opin Drug Discov. 2017; 18: 1-4. Kalyaanamoorthy S, Barakat KH. Development of safe drugs: the hERG challenge. Med Res Rev. 2017; doi: 10.1002/med.21445.

Effect of oral capsule- vs colonoscopy-delivered fecal microbiota transplantation on recurrent Clostridium difficile infection: a randomized clinical trial. JAMA. 2017; 318 (20): 1985-1993. Karvellas CJ, Cardoso FS, Senzolo M, Wells M, Alghanem MG, Handou F, Kwapisz L, Kneteman NM, Marotta PJ, Al-Judaibi B. Clinical impact of portal vein thrombosis prior to liver transplantation: a retrospective cohort study. Ann Hepatol. 2017; 16 (2): 236-436. Kieser Q, Paszkowski P, Lin J, Evans DH, Noyce R. Visualizing poxvirus replication and recombination using live cell imaging. Mercer J editor. Vaccinia virus: Methods and Protocols. Springer, New York, NY. 2017. Kowdley KV, Luketic V, Chapman R, Hirschfield GM, Poupon R, Schramm C, Vincent C, Rust C, Parés A, Mason A, Marschall HU, Shapiro D, Adorini L, Sciacca C, Beecher-Jones T, Böhm O, Pencek R, Jones D; Obeticholic Acid PBC Monotherapy Study Group. A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis. Hepatology. 2017; doi: 10.1002/hep.29569. Kuban-Jankowska A, Sahu KK, Gorska-Ponikowska M, Tuszynski JA, Wozniak M. Inhibitory activity of iron chelators ATA and DFO on MCF-7 breast cancer cells and phosphatase PTP1B and SHP2. Anticancer Res. 2017; 37 (9): 4799-4806. Lahmidi S, Strunk U, Smiley JR, Pearson A, Duplay P. Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2. Virology. 2017; 511: 66-73.

Kao D, Roach B, Silva M, Beck P, Rioux K, Kaplan GG, Chang HJ, Coward S, Goodman KJ, Xu H, Madsen K, Mason A, Wong GK, Jovel J, Patterson J, Louie T. Landi A, Law J, Hockman D, Logan M, Crawford K, Chen C, Kundu J, Ebensen T, Guzman CA,

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Deschatelets L, Krishnan L, Tyrrell DLJ, Houghton M. Superior immunogenicity of HCV envelope glycoproteins when adjuvanted with cyclic-diAMP, a STING activator or archaeosomes. Vaccine. 2017; 35 (50): 6949-6956. Lapetina DL, Ptak C, Roesner UK, Wozniak RW. Yeast silencing factor Sir4 and a subset of nucleoporins form a complex distinct from nuclear pore complexes. J Cell Biol. 2017; 216 (10): 3145-3159. Legg-St Pierre CB, Mackova M, Miskiewicz EI, Hemmings DG, Unniappan S, MacPhee DJ. Insulinotropic nucleobindin-2/nesfatin-1 is dynamically expressed in the haemochorial mouse and human placenta. Reprod Fertil Dev. 2017; doi: 10.1071/RD16486. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC. Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. PLoS One. 2017; 12 (4): e0175130. Lepre MG, Omar SI, Grasso G, Morbiducci U, Deriu MA, Tuszynski JA. Insights into the effect of the G245S single point mutation on the structure of p53 and the binding of the protein to DNA. Molecules. 2017; 22 (8): e1358. Lin CS, Chen JJW, Chiu CC, Hsiao HCW, Yang CJ, Jin XH, Leebens-Mack J, de Pamphilis CW, Huang YT, Yang LH, Chang WJ, Kui L, Wong GK, Hu JM, Wang W, Shih MC. Concomitant loss of NDH complex-related genes within chloroplast and nuclear genomes in some orchids. Plant J. 2017; 90 (5): 994-1006. Logan M, Law J, Wong JA, Hockman D, Landi A, Chen C, Crawford K, Kundu J, Baldwin L, Johnson J, Dahiya A, LaChance G, Marcotrigiano J, Law M, Foung S, Tyrrell L, Houghton M.

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Native folding of a recombinant gpE1/gpE2 heterodimer vaccine antigen from a precursor protein fused with Fc IgG. J Virol. 2017; 91 (1): e01552-16. Lopaticki S, Yang ASP, John A, Scott NE, Lingford JP, O-Neill MT, Erickson SM, McKenie NC, Jennison C, Whitehead LW, Douglas DN, Kneteman NM, Goddard-Borger ED, Boddey JA. Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts. Nat Commun. 2017; 8 (1): 561. López-Aladid R, Guiu A, Sanclemente G, LópezMedrano F, Cofán F, Mosquera MM, TorreCisneros J, Vidal E, Moreno A, Aguado JM, Cordero E, Martin-Gandul C, Pérez-Romero P, Carratalá J, Sabé N, Niubó J, Cervera C, Cervilla A, Bodro M, Muñoz P, Fariñas C, Codina MG, Aranzamendi M, Montejo M, Len O, Marcos MA. Detection of cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance. J Clin Virol. 2017; 90: 57-63. López-Medrano F, Fernández-Ruiz M, Silva JT, Carver PL, van Delden C, Merino E, Pérez-Saez MJ, Montero M, Coussement J, de Abreu Mazzolin M, Cervera C, Santos L, Sabé N, Scemla A, Cordero E, Cruzado-Vega L, Martin-Moreno PL, Len Ó, Rudas E, Ponce de León A, Arriola M, Lauzurica R, David MD, González-Rico C, Henríquez-Palop F, Fortún J, Nucci M, Manuel O, Paño-Pardo JR, Montejo M, Vena A, Sánchez-Sobrino B, Mazuecos A, Pascual J, Horcajada JP, Lecompte T, Moreno A, Carratalà J, Blanes M, Hernández D, Hernández-Méndez EA, Fariñas MC, Perelló-Carrascosa M, Muñoz P, Andrés A, Aguado JM . Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation. Clin Microbiol Infect. 2017; 24 (2): 192-198. Luck K, Jia Q, Huber M, Handrick V, Wong GK, Nelson DR, Chen F, Gershenzon J, Köllner TG.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Publications

CYP79 P450 monooxygenases in gymnosperms: CYP79A118 is associated with the formation of taxiphyllin in Taxus baccata. Plant Mol Biol. 2017; 95 (1-2): 169-180.

Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. FASEB J. 2017; 31 (9): 4064-4077.

Ma C, Claude KM, Kibendelwa ZT, Brooks H, Zheng X, Hawkes M.

Montano-Loza AJ, Bhanji RA, Wasilenko S, Mason AL.

Is maternal education a social vaccine for childhood malaria infection? A cross-sectional study from war-torn Democratic Republic of Congo. Pathog Glob Health. 2017; 111 (2): 98-106.

Systematic review: recurrent autoimmune liver diseases after liver transplantation. Ailment Pharmacol Ther. 2017; 45 (4): 485-500.

MacLeod SH, Potts KG, Chaurasiya S, Hitt MM. Assessment of specificity of an adenovirus targeted to HER3/4. Methods Mol Biol. 2017; 1652: 275-293.

Montano-Loza AJ, Mason AL. Recurrence of primary biliary cholangitis after liver transplantation: a Japanese perspective. Hepatol Commun. 2017; 1 (5): 391-393. Nabwire J, Namasopo S, Hawkes MT.

Oxygen availability and nursing capacity for Mandhane PJ, Paredes Zambrano de Silbernagel P, oxygen therapy in Ugandan paediatric wards. Aung YN, Williamson J, Lee BE, Spier S, Noseworthy J Trop Pediatr. 2017; doi: 10.1093/tropej/fmx033. M, Craig WR, Johnson DW. Nayebi N, Cetinel S, Omar SI, Tuszynski JA, Treatment of preschool children presenting to the Montemagno C. emergency department with wheeze with A computational method for selecting short azithromycin: a placebo-controlled randomized peptide sequences for inorganic material binding. trial. Proteins. 2017; 85 (11): 2024-2035. PLoS One. 2017; 12 (8): e0182411. McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC. Brain-derived neurotrophic factor is associated with disease severity and clinical outcome in Ugandan children admitted to hospital with severe malaria. Pediatr Infect Dis. 2017; 36 (2): 146-150. McGuire SH, Reitman EA, Siegelmann H, Tuszynski JA. Gibbs free energy as a measure of complexity correlates with time within C. elegans embryonic development. J Biol Phys. 2017; 43 (4): 551-563.

Okoye IS, Houghton M, Tyrrell L, Barakat K, Elahi S. Co-inhibitory receptor expression and immune checkpoint blockade: maintaining a balance in CD8+ T cell responses to chronic viral infections and cancer. Front Immunol. 2017; 8: 1215. Osiowy C, Andonov A, Fonseca K, Swidinskky K, Giles E, Mason A, Coffin CS. Transmission of hepatitis D virus between spouses: a longitudinal study of the first reported Canadian case. IDCases. 2017; 8: 37- 41.

Ouchenir L, Renaud C, Khan S, Bitnun A, Boisvert Meng G, Tang X, Yang Z, Benesch MGK, Marshall A, AA, McDonald J, Bowes J, Brophy J, Barton M, Ting J, Roberts A, Hawkes MT, Robinson JL. Murray D, Hemmings DG, Wuest F, McMullen TPW, Brindley DN. The epidemiology, management, and outcomes of bacterial meningitis in infants.

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Pediatrics. 2017; 140 (1): e20170476. Pagadala NS, Syed K, Tuszynski J. Software for molecular docking: a review. Biophys Rev. 2017; 9 (2): 91-102. Paproski RJ, Jovel J, Wong GK, Lewis JD, Zemp RJ. Enhanced detection of cancer biomarkers in blood-borne extracellular vesicles using nanodroplets and focused ultrasound. Cancer Res. 2017; 77 (1): 3-13. Pericàs JM, Messina JA, Garcia-de-la-Mària C, Park L, Sharma-Kuinkel BK, Marco F, Wray D, Kanafani ZA, Carugati M, Durante-Mangoni E, Tattevin P, Chu VH, Moreno A, Fowler VG Jr, Miró JM, International Collaboration on Endocarditis Microbiology Investigators (Cervera C). Influence of vancomycin minimum inhibitory concentration on the outcome of methicillinsusceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis. Clin Microbiol Infect. 2017; 23 (8): 544-549. Petkau K, Ferguson M, Guntermann S, Foley E. Constitutive immune activity promotes tumorigenesis in Drosophila intestinal progenitor cells. Cell Rep. 2017; 20 (8): 1784-1793. Potts KG, Irwin CR, Favis NA, Pink DB, Vincent KM, Lewis JD, Moore RB, Hitt MM, Evans DH. Deletion of F4L (ribonucleotide reductase) in vaccinia virus produces a selective oncolytic virus and promotes anti-tumor immunity with superior safety in bladder cancer models. EMBO Mol Med. 2017; 9 (5): 638-654. Preto J, Gentile F, Winter P, Churhill C, Omar SI, Tuszynski JA. Molecular dynamics and related computational methods with applications to drug discovery. Bonilla, Kaxiras, and Melnik editors. Coupled Mathematical Models for Physical and Biological

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Nanoscale Systems and Their Applications. Springer, Berlin. 2017. Ptak C, Wozniak RW. SUMO and nucleocytoplasmic transport. Adv Exp Med Biol. 2017; 963: 111-126. Rajwani J, Klinger CM, Arango E, Arroyo MI, Sabbagh A, Maestre A, Dacks JB, Gnidehou S, Yanow SK. Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the regions. Infect Genet Evol. 2017; 55: 175-185. Reid CR, Hobman TC. The nucleolar helicase DDX56 redistributes to West Nile virus assembly sites. Virology. 2017; 500: 169-177. Rietman EA, Scott JG, Tuszynski JA, Klement GL. Personalized anticancer therapy selection using molecular landscape topology and thermodynamics. Oncotarget. 2017; 8 (12): 18735-18745. Salari V, Barzanjeh Sh, Cifra M, Simon C, Scholkmann F, Alirezaei Z, Tuszynski JA. Towards non-invasive cancer diagnostics and treatment based on electromagnetic fields, optomechanics and microtubules. 2017; arXiv:1708.08339v1. Santelices IB, Friesen DE, Bell C, Hough CM, Xiao J, Kalra A, Kar P, Freedman H, Rezania V, Lewis JD, Shankar K, Tuszynski JA. Response to alternating electric fields of tubulin dimers and microtubule ensembles in electrolytic solutions. Sci Rep. 2017; 7 (1): 9594. Santer DM, Minty GES, Mohamed A, Baldwin L, Bhat R, Joyce M, Egli A, Tyrrell DLJ, Houghton M.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Publications

A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression. J Immunol Methods. 2017; 445: 15-22. Sarhan MA, Abdel-Hakeem MS, Mason AL, Tyrrell DL, Houghton M.

Physician perspective on vaccination and diagnostic testing in children with gastroenteritis: a primary care physician survey. Paediatrics & Child Health. 2017; 22 (6): 317-321. Steenbergen R, Oti M, ter Horst R, Tat W, Neufeldt C, Belovodskiy A, Chua TT, Cho WJ, Joyce MA, Dutilh B, Tyrrell DL.

Glycogen synthase 3β inhibitors prevent hepatitis C virus release/ assembly through perturbation of Induction of differentiation and metabolic lipid metabolism. reprogramming in human hepatoma cells by adult Sci Rep. 2017; 7 (1): 2495. human serum. bioRxiv (not peer-reviewed). 2017; doi: Seal A, Hawkes M, Bhargava R, Preiksaitis JK, https://doi.org/10.1101/180968. Mabilangan C, Robinson J. Radiation exposure from diagnostic imaging in a cohort of pediatric transplant recipients. PLoS One. 2017; 12 (1): e0167922. Sheff JG, Farshidfar F, Bathe OF, Kopciuk K, Gentile F, Tuszynski J, Barakat K, Schriemer DC. Novel allosteric pathway of Eg5 regulation identified through multivariate statistical analysis of hydrogen-exchange mass spectrometry (HXMS) ligand screening data. Mol Cell Proteomics. 2017; 16 (3): 428-437. Sikora C, Tipples G, Pang X-L, Andonov A. Hepatitis A virus infection associated with cannabis use. Can Commun Dis Rep. 2017; 43 (11): 245-6.

Tang JW, Lam TT, Zaraket H, Lipkin WI, Drews SJ, Hatchette TF, Heraud JM, Koopmans MP, Abraham AM, Baraket A, Bialasiewicz S, Caniza MA, Chan PK, Cohen C, Corriveau A, Cowling BJ, Echavarria M, Fouchier R, Fraaij P, Jalal H, Jennings L, Kabanda A, Kadjo HA, Khanani MR, Koay ES, Krajden M, Lee HK, Lutwama J, Marchant D, Nishimura H, Nymadawa P, Pinsky BA, Rughooputh S, Rukelibuga J, Saiyed T, Shet A, Sloots T, Tamfum JM, Tempia S, Tozer S, Treurnicht F, Waris M, Watanabe A, Wemakoy EO. The global epidemiology of non-influenza respiratory viruses: data gaps and a growing need for surveillance. Lancet Infect Dis. 2017; 17 (10): e320-e326.

Spasevska I, Ayoub AT, Winter P, Preto J, Wong GK, Taylor BJ, Lanke K, Banman SL, Morlais I, Morin MJ, Bousema T, Rijpma SR, Yanow SK. Dumontet C, Tuszynski JA. Modelling the Colchicum autumnale tubulin and a A direct from blood reverse transcriptase polymerase chain reaction assay for monitoring comparison of its interaction with colchicine to falciparum malaria parasite transmission in human tubulin. elimination settings. Int J Mol Sci. 2017; 18 (8): pii: e1676. Am J Trop Med Hyg. 2017; 97 (2): 533-543. Sperling JL, Silva-Brandão KL, Brandão MM, Lloyd Teferi WM, Desaulniers MA, Noyce RS, Shenouda VK, Dang S, Davis CS, Sperling FAH, Magor KE. M, Umer B, Evans DH. Comparison of bacterial 16S rRNA variable The vaccinia virus K7 protein promotes histone regions for microbiome surveys of ticks. methylation associated with heterochromatin Ticks Tick Borne Dis. 2017; 8 (4): 453-461. formation. Sperou AJ, Dickinson JA, Lee B, Louie M, Pang XL, PLoS One. 2017; 12 (3): e0173056. Chui L, Vanderkooi OG, Freedman SB; APPETITE. Tonello L, Cocchi M, Gabrielli F, Tuszynski JA.

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Stream of consciousness: quantum and biochemical assumptions regarding psychopathology. Med Hypotheses. 2017; 101: 78-84. Tonello L, Gashi B, Scuotto A, Capello G, Cocchi M, Gabrielli F, Tuszynski JA. The gastro-intestinal-brain axis in humans as an evolutionary advance of the root-leaf axis in plants. J Integr Neurosci. 2017; doi: 10.3233/JIN-170048. Tong Y, Pang XL, Mabilangan C, Preiksaitis JK.

Sensitivity of docetaxel-resistant MCF-7 breast cancer cells to microtubule-destabilizing agents including vinca alkaloids and colchicine-site binding agents. PLoS ONE. 2017; 12 (8): e0182400. Wang W, Zhang H, Wang X, Patterson J, Winter P, Graham K, Gosh S, Lee JC, Katsetos CD, Mackey JR, Tuszynski JA, Wong GK, Ludueña RF. Novel mutations involving βI-, βIIA-, or βIVBtubulin isotypes with functional resemblance to βIII-tubulin in breast cancer. Protoplasma. 2017; 254 (3): 1163-1173.

Determination of the biological form of human Weismüler TJ, Trivedi PJ, Bergquist A, Imam M, cytomegalovirus DNA in the plasma of solid-organ Lenzen H, Ponsioen CY, Holm K, Gotthardt D, transplant recipients. Fäkkilä MA, Marschall HU, Thorburn D, Weersma J Infect Dis. 2017; 215 (7): 1094-1101. RK, Fevery J, Mueller T, Chazouillères O, Schulze K, Turvey SL, Tyrrell GJ, Hernandez C, Kabbani D, Lazaridis KN, Almer S, Pereira SP, Levy C, Mason A, Doucette K, Cervera C. Naess S, Bowlus CL, Floreani A, Halilbasic E, Yimam KK, Milkiewicz P, Beuers U, Huynh DK, Pares A, Mycobacterium branderi infection : Case report Manser CN, Dalekos GN, Eksteen B, Invernizzi P, and literature review of an unusual and difficultBerg CP, Kirchner GI, Sarrazin C, Zimmer V, Fabris L, to-treat non-tuberculous mycobacterium. Braun F, Marzioni M, Juran BD, Said K, Rupp C, Int J Infect Dis. 2017; 58: 65-67. Jokelainen K, Benito de Valle M, Saffioti F, Cheung Vanpouille C, Bernatchez JA, Lisco A, Arakelyan A, A, Trauner M, Schramm C, Chapman RW, Karlsen Saba E, Götte M, Margolis L. TH, Schrumpf E, Strassburg CP, Manns MP, Lindor A common anti-cytomegalovirus drug, ganciclovir, KD, Hirschfield GM, Hansen BE, Boberg KM; International PSC Study Group. inhibits HIV-1 replication in human tissues ex vivo. AIDS. 2017; 31 (11): 1519-1528.

Velpula KK, Guda MR, Sahu K, Tuszynski J, Asuthkar S, Bach SE, Lathia JD, Tsung AJ. Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma. Oncotarget. 2017; 8 (22): 35639-35655. Vink EI, Smiley JR, Mohr I. Subversion of host responses to energy insufficiency by US3 supports herpes simplex virus 1 replication during stress. J Virol. 2017; 91 (14): pii: e00295-17. Wang RC, Chen X, Parissenti AM, Joy AA, Tuszynski JA, Brindley DN, Wang Z.

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Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis. Gastroenterology. 2017; 152 (8): 1975-1984. Xu Z, Asahchop EL, Branton WG, Gelman BB, Power C, Hobman TC. MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: implications for virus biology, disease mechanisms and neuropathology. PLoS Pathog. 2017; 13 (6): e1006360. Yang ASP, Lopaticki S, O’Neill MT, Erickson SM, Douglas DN, Kneteman NM, Boddey JA. AMA1 and MAEBL are important for Plasmodium falciparum sporozoite infection of the liver.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Publications

Cell Microbiol. 2017; 19 (9): doi:10.1111/cmi.12745. Yang ASP, Oâ&#x20AC;&#x2122;Neill MT, Jennison C, Lopaticki S, Allison CC, Armistead JS, Erickson SM, Rogers KL, Ellisdon AM, Whisstock JC, Tweedell RE, Dinglasan RR, Douglas DN, Kneteman NM, Boddey JA. Cell traversal activity is important for Plasmodium falciparum liver infection in humanized mice. Cell Rep. 2017; 18 (13): 3105-3116. Yu Y, Xiang Q, Manos PS, Soltis DE, Soltis PS, Song BH, Cheng S, Liu X, Wong G. Whole-genome duplication and molecular evolution in Cornus L (Cornaceae)- insights from transcriptome sequences. PLoS One. 2017; 12 (2): e0171361. Zhuo R, Cho J, Qiu Y, Parsons BD, Lee BE, Chui L, Freedman SB, Pang X; APPETITE. High genetic variability of norovirus leads to diagnostic test challenges. J Clin Virol. 2017; 96: 94-98.

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INVITED PRESENTATIONS Troy Baldwin

• Immune function in the face of persistent antigen- lessons from the thymus? 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

Khaled Barakat

• Rational design of small molecule immune checkpoints’ inhibitors: the PD-1 challenge. Applied Microbiology Conference. Toronto, ON, CAN.

• Rational design of small molecule immune checkpoints’ inhibitors: the PD-1 challenge. Vaccine Innovation Conference. Montreal, QC, CAN.

• HEKA Therapeutics: Spin off for the immune checkpoints program at the University of Alberta, Canada. Merck Inc. Kenilworth, NJ, USA.

Deborah Burshtyn

• HCMV immune evasion protein UL18 and innate immune receptor diversity.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

• Did cytomegalovirus’ immune evasion protein UL18 force down the human inhibitory receptor LILRB1 on NK cells. ImmuNet Seminar Series, University of Alberta. Edmonton, AB, CAN.

Carlos Cervera

• CMV: prevention and therapy.

2017 Canadian Society of Transplantation- Cell Transplant and Regenerative Medicine Society Joint Scientific Meeting. Halifax, NS, CAN.

Karen Doucette

• Using hepatitis C positive donors in negative recipients.

American Association for the Study of Liver Diseases Conference (Transplant Surgery Workshop). Washington, DC, USA.

David Evans

• Synthesis of horsepox and its implications for national security (videoconference).

Tucker Symposium. James Martin Center for Nonproliferation Studies (Monterey Institute) and the Center for the Study of Weapons of Mass Destruction (National Defense University). Washington, DC, USA.

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LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Invited Presentations

• Fun with poxviruses.

Alberta Health Innovators Association. Edmonton, AB, CAN.

• Virus synthesis as a tool for assembling large virus vaccines. SB7.0 Synthetic Biology Conference. Singapore, SGP.

• Virus synthesis as a tool for assembling large virus vaccines.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

• Poxvirus technologies.

Vaccine Innovation Conference. Montreal, QC, CAN.

• Synthetic poxviruses: generation of a novel smallpox vaccine. Tonix Pharmaceuticals and Sanofi Inc. Teleconference.

• University of Alberta containment level 2 and 3 facilities. Department of National Defense. Suffield, AB, CAN.

• Poxvirus technologies.

Merck Inc. Kenilworth, NJ, USA.

• Why and how to communicate with decision makers.

Canadian Association for HIV Research. Banff, AB, CAN.

Edan Foley

• Inflammation and tumorigenesis in the Drosophila intestine.

2017 Genomics Society of America 58th Annual Drosophila Research Conference. San Diego, CA, USA.

• Inflammation and tumorigenesis in the Drosophila intestine. Alberta Diabetes Institute. Edmonton, AB, CAN.

Matthias Götte

• Training opportunities in virology and infectious diseases at MMI.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

• Novel targets for antiviral drug discovery and development efforts.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

Michael Hawkes

• Medcan Naweza: AFYACHAT to tackle non-communicable disease in rural Kenya. Medcan Continuing Medical Education Conference.

• Global childhood infections and the endothelium: therapeutics and biomarkers. ImmuNet Seminar Series, University of Alberta. Edmonton, AB, CAN.

• The art of global health.

Aga Khan Health Board. Edmonton, AB, CAN.

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• Solar powered oxygen delivery.

World Expo 2017, Future Energy. Astana, KAZ.

• Solar powered oxygen delivery.

Moderated Expert Plenary Session, Future Energy Forum, Energy for All. Astana, KAZ.

• Inflammatory markers in the EPIC4 cohort.

National meeting EPIC4 Study Group. Montreal, QC, CAN.

• Top infectious diagnoses in the returning traveler.

Pediatric Infectious Diseases Conference, Continuing medical education. Banff, AB, CAN.

• Common antibiotics for common infections.

Pediatric Infectious Diseases Conference, Continuing Medical Education. Banff, AB, CAN.

Bart Hazes

• From bytes to bench to bedside.

ImmuNet Seminar Series, University of Alberta. Edmonton, AB, CAN.

Denise Hemmings

• Cytomegalovirus infection and sphingosine 1-phosphate signalling in vascular and metabolic function during aging. University of Illinois at Chicago. Chicago, IL, USA.

• Cytomegalovirus, bioactive lipids and vascular function in pregnancy. University of Ottawa. Ottawa, ON, CAN.

• Perinatal stress and health fetal/ child development: the mother is more influential than the father? Canadian National Perinatal Research Meeting. Montebello, QC, CAN.

• Cytomegalovirus infection and sphingosine 1-phosphate signalling in vascular and metabolic function during aging. Cardiovascular Research Centre. Edmonton, AB, CAN.

Tom Hobman

• RNA virus host interactions at the cellular level.

University of Saskatchewan. Saskatoon, SK, CAN.

• RNA virus host interactions at the cellular level.

National Institutes of Health. Rocky Mountain Labs, MT, USA.

• Zika virus host interactions: persistence and pathogenesis.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

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LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Invited Presentations

• Astrocytes are a major target for Zika virus replication and persistence in the human fetal brain. American Society for Virology. Madison, WI, USA.

• Modulation of host stress response by Zika virus. Heidelberg, DE.

Mary Hitt

• Development of F4L-deleted vaccinia virus as an oncolytic virus for the treatment of bladder cancer. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

Michael Houghton • Programs of the Li Ka Shing Applied Virology Institute.

National Meeting on Infectious Diseases. Edmonton, AB, CAN.

• Designing, producing, and testing a HCV vaccine at the University of Alberta. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

• The discovery and prevention of HCV. CanHepC. Ottawa, ON, CAN.

• Translating research from the bench to the clinic and commercialization. Alberta Innovates Meeting. Ottawa, ON, CAN.

• 30-year journey: winning the battle against hepatitis C.

Eggheads & Bacon Breakfast, Ottawa MPs on HCV. Ottawa, ON, CAN.

Katharine Magor

• Subversion of influenza detection by RIG-I in the reservoir host.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

• Influenza detection and defense in the reservoir host.

Genetic Bases for Resistance and Immunity to Avian Diseases. Charlottetown, PEI, CAN.

David Marchant

• Transmission of respiratory syncytial virus in cells and the community.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

Andrew Mason

• The Canadian PBC landscape.

CDDW Annual Meeting. Banff, AB, CAN.

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• Predicting mortality for patients with PBC or PSC- biomarkers and beyond. CDDW Annual Meeting. Banff, AB, CAN.

• PBC as a possible viral disease.

Global PBC Symposium: Global PBC Study Group: optimizing and prioritizing future clinical research in PBC, EASL Annual Meeting. Amsterdam, NLD.

• Canadian perspective and history of PBC.

Canadian PBC Society Meeting. Victoria, BC, CAN.

• Top ten reasons to talk about PBC.

PBC community meeting with the Canadian PBC Society. Duncan, BC, CAN.

Robert Ingham

• The function of the c-Jun and JunB transcription factors in B and T cell lymphomas. ImmuNet seminar series. Edmonton, AB, CAN.

David Marchant

• Transmission of respiratory syncytial virus in cells and the community. East West Alliance Meeting. Oxford, UK.

• Transmission of respiratory syncytial virus in cells and the community. Virology Research Seminar, East West Alliance Meeting. London, UK.

Jutta Preiksaitis

• Impact of cytomegalovirus and its prevention strategies on survival in thoracic transplant. International Society for Heart & Lung Transplantation. San Diego, CA, USA.

• CMV-specific T-cell immunity and CMV NAAT in assignment of CMV status in pediatric SOT candidates. International Society for Heart & Lung Transplantation. San Diego, CA, USA.

Maya Shmulevitz

• Reshaping oncolytic reovirus for the tumor niche. Saskatoon, SK, CAN.

• Reshaping oncolytic reovirus for the tumor niche. Halifax, NS, CAN.

• Reshaping oncolytic reovirus for the tumor niche.

Gordon Research Conference on Physical Virology. Tuscany II Ciocco, Lucca (Barga), ITA.

• Reforming enteric reovirus to thrive in the tumor niche.

ImmuNet Seminar Series, University of Alberta. Edmonton, AB, CAN.

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LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Invited Presentations

James Smiley

• Regulation of translation and innate immunity by the herpes simplex virus host shutoff ribonuclease. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

Graham Tipples

• The public health laboratory role in enteric surveillance and future directions of testing platforms. APPETITE Research Project Retreat. Calgary, AB, CAN.

• The public health laboratory role for emerging diseases.

One Health Global Health Seminar Series, Department of Ecosystem and Public Health. Calgary, AB, CAN.

Jack Tuszynski

• Microtubules as subcellular memristors.

41st Systems Conference on Super Intelligent Machines and Man. Agra, IND.

• Roundtable Panel Member.

Italian Society of Experimental Biology Annual Meeting. Trapani, ITA.

• Systems biology and disease.

International Course on Theoretical and Applied Aspects of Systems Biology. FioCruz, Rio de Janeiro, BRA.

• How memories are made?

Pre-Plenary Workshop East Meets West, The Science of Consciousness Conference. San Diego, CA, USA.

• Introduction to quantum biology.

Quantum Brain Biology Workshop, The Science of Consciousness Conference. San Diego, CA, USA.

• Microtubules as subcellular memristors.

The Science of Consciousness Conference. San Diego, CA, USA.

• Using mathematical measures of network complexity and image analysis for cancer diagnostics and therapy design. 2017 IEEE International Instrumentation and Measurement Technology Conference. Turin, ITA.

• AC conductance and capacitance of microtubules up to 1 MHz. Inovovitro US Users Meeting. Fort Lauderdale, FL, USA.

D Lorne Tyrrell

• Alumni and Friends Event. Ottawa and Toronto, ON, CAN.

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• Scientists respond to Canada’s fundamental science review, the Naylor Report. Roundtable Discussion. Edmonton, AB, CAN.

• Transforming viral hepatitis.

Inaugural Distinguished Scientist Lecture, Concordia University of Edmonton. Edmonton, AB, CAN.

• Studies in viral hepatitis.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

• Hepatitis C: a major medical victory.

Alberta Health Industry Association. Edmonton, AB, CAN.

Gane Ka-Shu Wong

• Applied biodiversity: from quantitative protein characterizations to genetic networks of complex traits. Ocean University of China, Qingdao, CHN.

• From technology development to biodiversity sequencing to medical applications and back. Hong Kong, China SAR.

Stephanie Yanow • The pathogenesis of P. falciparum and P. vivax in pregnancy.

EMBO course on Malaria Genomics and Public Health. Madurai, IND.

• Probing the function of virulence proteins from different species of malaria. School of Public Health Research Seminar Series. Edmonton, AB, CAN.

• Molecular tools for malaria surveillance and elimination.

Host-Parasite Interactions: From Molecules to Ecosystems. Banff, AB, CAN.

• A novel mechanism of cross-species immunity to malaria. ImmuNet Seminar Series. Edmonton, AB, CAN.

• Malaria diagnosis.

EMBO course on Malaria Genomics and Public Health. Madurai, IND.

• Antibodies to Plasmodium vivax PvDBP reveal a mechanism for cross-species immunity to P. falciparum placental malaria. Annual meeting of the American Society of Tropical Medicine and Hygiene. Baltimore, MD, USA.

• Antibodies to Plasmodium vivax PvDBP recognize VAR2CSA and block adhesion of P. falciparum-infected red cells to chondroitin sulphate A. 6th International Conference on Plasmodium vivax Research. Manaus, BRA.

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LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Abstracts and Presentations

ABSTRACTS AND PRESENTATIONS

Li Ka Shing Institute of Virology Principal Investigators in Bold Airo AM, Urbanowski M, Lopez-Orozco J, You J, Skene-Arnold T, Holmes C, Malik-Soni N, Frappier L, Hobman TC. Expression of flavivirus capsids enhance the cellular environment for viral replication by activating Akt-signaling pathways. 17th International Congress of Virology. Singapore, SGP.

Belga S, Hernandez C, Kabbani D, Doucette K, Fuentes S, Chiang D, Cervera C. Neutropenia rates of antiviral prophylaxis in CMV high risk solid organ transplant recipients. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. JAMMI 2017; 2:111. Berry-Wynne K, Joyce M, McFarlane N, Addison B, Tyrrell L. HCV infection induces PDLIM2 regulation of STAT2.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Alipour M, Armstrong H, Valcheva RS, Zaidi D, Jovel Edmonton, AB, CAN. J, Lou Y, Mason A, Wong G, Madsen K, Dieleman LA, Carroll MW, Huynh HQ, Wine E. Brophy J, Kakkar F, Dieumegard H, Bitnun A, Hawkes M, Samson L, Ransy D, Janelle-Montcalm Identification of pathogenic bacterial strains in A, Read S, Soudeyns H; Early Pediatric Initiation of paediatric patients with inflammatory bowel Combination Antiretroviral Therapy, Canada Child diseases using immunoglobulin G as a marker of Cure Cohort Study (EPIC4). virulence. Impact of timing and duration of virologic CDDW Annual Meeting. Banff, AB, CAN. suppression on HIV serologic and ELISpot Alipour M, Valcheva R, Armstrong H, Saidi D, Jovel responses in the early pediatric initiation of J, Lou Y, Mason A, Wong G, Dieleman L, Carroll M, combination antiretroviral therapy, Canada child Huynh H, Wine E. cure cohort study (EPIC4). Immunoglobulin G selectively identifies 21st International Workshop on HIV and Hepatitis pathosymbionts in paediatric inflammatory bowel Observational Databases. Lisbon, PRT. diseases. Brophy J, Kakkar F, Dieumegard H, Hawkes M, Crohnâ&#x20AC;&#x2122;s and Colitis Foundation National Clinical Samson L, Read S, Bitnun A, Soudeyns H; Early and Research Conference, Inflammatory Bowel Pediatric Initiation of Combination Antiretroviral Diseases. Lake Buena Vista, FL, USA. 2017; doi: Therapy, Canada Child Cure Cohort Study (EPIC4). 10.1097/01.MIB.0000512864.34774.10 Impact of timing and duration of virologic Belga S, Doucette K, Preiksaitis J, Massolo A, Klein suppression on HIV serologic and ELISpot C, et al. responses in the EPIC4 cohort. Alveolar echinococcosis in Alberta: an emerging infectious disease in North America?

26th Annual Canadian Conference on HIV/AIDS Research. Montreal, QC, CAN.

Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. JAMMI 2017; 2:65.

Burshtyn DN, Yu K, Wojtowicz A, Sandalova T, Humar A, Bochud P-Y, Achour A, Lisboa L, Mueller N, Egli A.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

LILRB1 polymorphism, post-transplant CMV and interaction with HCMV-UL18 and classical MHC-1.

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Cell Symposia: Human Immunity. Banff, AB, CAN. Burton C, Preiksaitis JK, Sester M, Tong Y, Wong F, Urschel S. CMV-specific T-cell immunity and CMV NAAT in assignment of CMV status in pediatric SOT candidates. International Society for Heart & Lung Transplantation. San Diego, CA, USA. J Heart Lung Transplant 2017; 36(4S): 723. Chen H, Potts K, Murray A, Hitt M, Moore RB. Combined inhibition of autophagy with mTOR inhibitor to enhance cell death in renal cell carcinoma. American Society of Clinical Oncology Annual Meeting. Chicago, IL, USA. Chua TT, Fischer K, Joyce MA, Steenbergen R, Tyrrell DL. HS cultured Huh7: a potential in vitro model of secreting two different HAV populations. Alberta Virology Conference. Edmonton, AB, CAN. Chua TT, Pang D, Joyce MA, Steenbergen R, Tyrrell DL. HS cultured Huh7 cells and chimeric mice model: the potential models to separate two different hepatitis A virus populations.

Developing a TRAIL-expressing oncolytic vaccinia virus for use as a novel combination therapy for cancer. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Dauber B, dos Santos T, Poon D, Saffran H, Smiley J. Mechanisms of PKR suppression by the HSV virion host shutoff ribonuclease. 42nd International Herpesvirus Workshop. Ghent, BEL. Podium presentation. Dieumegard H, Ransy D, Fourati IS, Taillefer S, Janelle-Montcalm A, Caty M, Valois S, Read S, Lapointe N, Boucher M, Samson L, Hawkes MT, Lamarre V, Kakkar F, Bitnun A, Brophy J, Soudeyns H; Early Pediatric Initiation of Combination Antiretroviral Therapy, Canada Child Cure Cohort Study (EPIC4). Impact of sustained virologic suppression on HIVspecific cell-mediated immune responses in children and adolescents. 26th Annual Canadian Conference on HIV/AIDS Research. Montreal, QC, CAN. Dong J, Paszkowski P, Lehman B, Barry M, Ingham RJ.

2017 ImmuNet Research Day. Edmonton, AB, CAN. The role of p28 during poxviral infection. Podium presentation. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Coffin C, Ramji A, Cooper C, Minuk G, Doucette K, Edmonton, AB, CAN. et al. Dong J, Paszkowski P, Lehman B, Barry M, Ingham A retrospective nationwide study on hepatitis B epidemiology and genotypes. The Canadian HBV RJ. Network.

The role of p28 during poxviral infection.

American Association for the Study of Liver Diseases Conference. Washington, DC, USA. Hepatology 2017; 66 (S1): 996.

2017 ImmuNet Research Day. Edmonton, AB, CAN.

Crosley P, Agopssowicz K, Potts K, Umer B, Pihlajoki M, Heikinheimo M, FĂ¤rkkilĂ¤ A, Evans D, Hitt M.

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Edgeworth D, Mackova M, Hemmings DG. Cytomegalovirus and the elderly: innocuous infection or physiological stressor? Obstetrics and Gynecology Research Day 2017. Edmonton, AB, CAN. Podium presentation.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Abstracts and Presentations

Fakhr Y, Mackova M, Hemmings DG. BeWo cells do not accurately model the effects of TNF-α on sphingosine 1-phosphate receptor 2 expression in human trophoblasts. Women and Children’s Health Research Institute (WCHRI) Research Day. Edmonton, AB, CAN.

Pediatric Academic Societies Meeting. San Francisco, CA, USA. Podium presentation. Freedman SB, Xie J, Nettle-Aguirre A, Lee B, Chui L, Pang XL, Zhou R, Parsons B, Dickenson JA, Vanderkooi O, Ali S, Osterreicher L, Lowerison K, Tarr PI; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE).

Fleming-Canepa X, Canniff L, Tetrault D, Aldridge JR Enteropathogen detection in children with acute Jr, Miranzo-Navarro D, Webster RG, Magor KE. gastroenteritis: a comparison of rectal flocked swabs and stool specimens. Duck RLR pathway genes are highly induced by H5N1 influenza.

North American Comparative Immunology Workshop. Raleigh, NC, USA. Freedman S, Nettle-Aguirre A, Xie J, Lee B, Chui L, Pang XL, Zhuo R, Parsons B, Dickinson J, Vanderkooi OG, Ali S, Osterreicher L, Lowerison K, Tarr P; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE). Enteropathogen detection in children with diarrhoea and/or vomiting: a cohort study comparing rectal flocked swabs and stool specimens. Infectious Diseases Society of America (IDSA): ID Week. San Diego, CA, USA. Podium presentation. Freedman S, Xie J, Nettle-Aguirre A, Lee B; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE).

Research Day Alberta Children’s Hospital. Calgary, AB, CAN.

Freedman SB, Xie J, Nettle-Aguirre A, Lee B, Chui L, Pang XL, Zhuo R, Parsons B, Vanderkooi OG, Tarr P, Ali S, Dickinson JA, Hagen E, Svenson LW, MacDonald SE, Drews SJ, Tellier R, Graham T, Lavoie M; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE). Relationship between enteropathogen and acute gastroenteritis disease severity: a prospective cohort study. Infectious Diseases Society of America (IDSA): ID Week. San Diego, CA, USA. Friedman D, Cervera C, Halloran K, Tyrrell G, Doucette K.

The prevalence and risk factors for nontuberculous mycobacterial infection in lung Relationship between enteric pathogen and acute transplant patients and its impact on patient survival and graft function. gastroenteritis disease severity: a prospective cohort study- APPETITE study. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of 2017 American Academy of Pediatrics (AAP) Medical Microbiologists of Canada (AMMI) National Conference & Exhibition. Chicago, IL, Meeting. Toronto, ON, CAN. JAMMI 2017; 2:29. USA. Freedman SB, Xie J, Nettel-Aguirre A, Lee B, Chui L, Pang XL, Zhou R, Dickinson JA, Vanderkooi OG, Ali S, Osterreicher L, Lowerison K, Tarr P; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE). Enteropathogen detection in children with acute gastroenteritis: a comparison of flocked rectal swabs and stool.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Frommelt L, Noyce R, Saffran H, Smiley J, Evans D. Development of a novel oncolytic poxvirus expressing the HSV alkaline nuclease UL12.5 to enhance anti-tumour immunity. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Gatselis N, Goet J, Zachou K, Lammers W, Janssen

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H, Hirschfield G, Corpechot C, Lindor K, Invernizzi P, Mayo M, Battezzati P, Floreani A, Pares A, Ligoura V, Nevens F, Mason A, Kowdley K, Ponsioen C, Bruns T, Thorburn D, Verhelst X, Harms M, van Buuren H, Hansen B, Dalekos G. Moving from early to moderate or advanced biochemical disease stage during follow-up is associated with an increasing risk of clinical events in primary biliary cholangitis patients. AASLD Annual Meeting. Washington, DC, USA. Hepatology 2017; 66(1): S169A. German GJ, Pelude L, Minion J, Poutanen S, Lee B, Davis I, Suh K, Thampi N, Larios O, Lefebvre MA, Ellis C, Lavallée C, Amaratunga K, Mulvey M; Canadian Nosocomial Infection Surveillance Program (CNISP). Antimicrobial susceptibilities of Escherichia coli in Canadian hospitals through the analysis of annual antibiogram summaries. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. Goet JC, Lammers WJ, Floreani A, Pares A, Janssen HLA, Hirschfield GM, van Buuren HR, Corpechot C, Invernizzi P, Lindor KD, Mayo MJ, Battezzati PM, Nevens F, Mason AL, Kowdley KV, Ponsioen CY, Bruns T, Dalekos GN, Thorburn D, Verhelst X, Gatselos NK, Trivedi PJ, Poupon R, Hansen BE. The GLOBE score identifies PBC patients at increased risk of liver transplantation or death in different age-categories over time. EASL Annual Meeting. Amsterdam, NLD. Journal of Hepatology 2017; 66: S368. Golec DP, Hoeppli R, Levings M, Baldwin TA. Agonist selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes (IEL) requires RASGRP1. 30th Annual Meeting of the Canadian Society for Immunology. Banff, AB, CAN. Golec DP, Hoeppli R, Levings M, Baldwin TA.

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Agonist selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes (IEL) requires RASGRP1. 7th International Workshop of Kyoto T Cell Conference. Kyoto, JPN. Hasing E, Lee B, Qiu Y, Xia M, Tipples G, Jiang X, Pang X. Molecular epidemiology of norovirus outbreaks in Alberta Canada: 2012-2016. DRIvE Day in Laboratory Services & Pathology. Edmonton, AB, USA. Hasing E, Zhuo R, Tipples G, Freedman S, Lee B, Pang X; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE). Emergence of a novel norovirus GII.P16/GII.2 strain in Alberta, Canada in 2016. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Hawkes MT, Brooks H, Makelele KJP, Mocanu V, Kasereka MC. Use and disuse of malaria bednets in the Democratic Republic of the Congo: a mixedmethods study. American Society of Tropical Medicine and Hygiene 66th Annual Meeting. Baltimore, MD, USA. Hawkes MT, Soo J, Brophy J, Kakkar F, Bitnun A, Samson L, Read S, Dieumegard H, Soudeyns H; Early Pediatric Initiation of Combination Antiretroviral Therapy, Canada Child Cure Cohort Study (EPIC4). Residual inflammation and endothelial activation in HIV-1 vertically infected children with fully suppressed viral replication on anti-retroviral therapy. 26th Annual Canadian Conference on HIV/AIDS Research. Montreal, QC, CAN. Hawkes MT, Soo J, Brophy J, Kakkar F, Bitnun A, Samson L, Read S, Dieumegard H, Soudeyns H; Early Pediatric Initiation of Combination

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Abstracts and Presentations

Antiretroviral Therapy, Canada Child Cure Cohort Study (EPIC4).

transmission to CMV naĂŻve lung transplant recipients.

Angiopoietin-1 and endothelial quiescence are associated with early initiation of cART in vertically HIV-1 infected children.

International Society for Heart & Lung Transplantation. San Diego, CA, USA. J Heart Lung Transplant 2017; 36(4S): 102.

26th Annual Canadian Conference on HIV/AIDS Research. Montreal, QC, CAN. Podium presentation.

Hirji A, Kabbani D, Hernandez C, Malhi H, Chandrarathne S, Halloran K, Kapasi A, Weinkauf J, Lien D, Preiksaitis JK, Cervera C.

Hawkes MT, Turnbull H, Amirav I, Solomon I, Aldar Y, Sahika SE, Kasereka MC.

Is there a role for pre-transplant cytomegalovirus (CVM) immunoglobulin G optical density to predict CMV infection in seropositive lung transplant recipients?

Development of a novel device for objective respiratory rate measurement in low resource settings.

International Society for Heart & Lung Transplantation. San Diego, CA, USA. J Heart Lung American Society of Tropical Medicine and Hygiene Transplant 2017; 36(4S): 615. 66th Annual Meeting. Baltimore, MD, USA. Johnson J, Law, J, Cheung F, Freedman H, He J, Hemmings D, Cao A, Kerage D, Mackova M, Houghton M. Brindley D. Examination of the molecular mechanisms that Sexual dimorphism of metabolic and vascular determine the breadth of cross neutralization of dysfunction in aged mice lacking the sphingosine HCV. 1-phosphate 3 receptor. 6th Canadian Symposium on Hepatitis C Virus. FASEB Summer Research Conference. New Banff, AB, CAN. Orleans, LA, USA. Johnson J, Law J, Freedman H, He J, Houghton M. Hernandez C, Abraldes JG, Chiang D, Kwan A, Investigation of the molecular mechanisms that Gulhati V, Saran A, Fuentes S, Cervera C. determine the breadth of cross neutralization of Early use of mTOR inhibitors and risk of HCV. cytomegalovirus infection in liver transplant patients. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. ECCMID Conference. Vienna, AT. Edmonton, AB, CAN. Hernandez C, Chiang D, Fuentes S, Cervera C. Johnson J, Law J, Freedman H, He J, Houghton M. Kinetics of cytomegalovirus (CMV) DNAemia in Investigation of the molecular mechanisms that CMV mismatch solid organ transplant patients determine the breadth of cross neutralization of with primary CMV infection. HCV. 2017 American Transplant Congress. Chicago, IL, 2017 ImmuNet Research Day. Edmonton, AB, CAN. USA. Johnson J, Law J, Freedman H, He J, Houghton M. Hernandez C, Hirji A, Kabbani D, Fuentes S, Mahli H, Chandrarathne S, Halloran K, Weinkauf J, Kapasi Investigation of molecular mechanisms that determine isolate-specific differences in A, Lien D, Preiksaitis JK, Cervera C. neutralization sensitivity of HCV by vaccineInfluence of donor cytomegalovirus (CMV) induced antibodies. immunoglobulin G (IgG) optical density on CMV

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24th International Symposium on Hepatitis C Virus and Related Viruses. Cape Cod, MA, USA. Joyce MA, Addison W, Berry-Wynne K, McFarlane N, Tyrrell DLJ. HCV infection induces PDLIM2 regulation of STAT2. Keystone Symposia on Molecular and Cellular Biology. Banff, AB, CAN.

LMD, Minion J, Stagg P, Lemieux C, Hota S, Science M, Thampi N, Quach C, Richardson S, Du T, Alexandre S; Canadian Nosocomial Infection Surveillance Program (CNISP). Molecular and epidemiological characterization of healthcare-associated Clostridium difficile infections among adults in Canada, 2009-2015.

Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Kabbani D, Hirji A, Hernandez Garcia C, Malhi H, Medical Microbiologists of Canada (AMMI) Chandrarathne S, Kapasi A, Weinkauf J, Halloran K, Meeting. Toronto, ON, CAN. Lien D, Preiksaitis JK, Cervera C. Kelly R, Baldwin TA. Incidence and characteristics of cytomegalovirus Investigating the role of PD-1 in the establishment infection among R+ lung transplant recipients and maintenance of T cell tolerance. receiving 3 months of antiviral prophylaxis. 30th Annual Meeting of the Canadian Society for International Society for Heart & Lung Immunology. Banff, AB, CAN. Transplantation. San Diego, CA, USA. J Heart Lung Transplant 2017; 36(4S): 618. Kneteman N. Kakkar F, Brophy J, Dieumegard H, Bitnun A, Hawkes M, Samson L, Ransy D, Janelle-Montcalm A, Read S, Soudeyns H; Early Pediatric Initiation of Combination Antiretroviral Therapy, Canada Child Cure Cohort Study (EPIC4). Early pediatric initiation of combination antiretroviral therapy, Canada child cure cohort study (EPIC4). 21st International Workshop on HIV and Hepatitis Observational Databases. Lisbon, PRT. Kakkar F, Brophy J, Samson L, Hawkes M, Read S, Soudeyns H; Early Pediatric Initiation of Combination Antiretroviral Therapy, Canada Child Cure Cohort Study (EPIC4). Angiopoietin-1 and endothelial quiescence are associated with early initiation of cART in vertically HIV-1 infected children. 26th Annual Canadian Conference on HIV/AIDS Research. Montreal, QC, CAN. Podium presentation. Katz K, Golding G, Choi K, Amaratunga K, Moore D, Simor A, Taylor G, Frenette C, Kibsey P, Suh K, Evans G, Mertz D, Wong A, Munira M, Longtin Y, Davis L, Lee B, Collet JC, Langley J, Mieusement

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Optimizing HCC guidelines for indications for transplantation. Canadian Liver Transplant Network. Halifax, NS, CAN. Podium presentation. Kumar A, Hou S, Hobman T. Modulation of host stress response by Zika virus. Stress-Associated RNA Granules in Human Disease and Viral Infection 2nd International Symposium. Heidelberg, DEU. Labak CM, Guda MR, Asuthkar S, Jain N, Lu Y, Purvis IJ, Tsung AJ, Tuszynski JA, Nakano I, Velpula KK. Î&#x2019;-tubulin inhibitors reduce GLUT1 membrane trafficking to attenuate tumorigenesis in glioblastoma subtypes. American Association of Cancer Research (AACR) Annual Congress. Washington, DC, USA. Lammers W, Goet J, Mayo M, Floreani A, Invernizzi P, Harms M, Corpechot C, Lindor K, Ponsioen C, Janssen H, Thorburn D, Battezzati P, Nevens F, Dalekos G, Pares A, Bruns T, Mason A, Kowdley K, Hirschfield G, Verhelst X, Hansen B , van Buuren H.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Abstracts and Presentations

Ursodeoxycholic Acid is associated with a prolonged transplant-free survival in all patients with primary biliary cholangitis- there is no such thing as non-response. AASLD Annual Meeting. Washington, DC, USA. Hepatology 2017; 66(1): S157A. Landi A, Law J, Hockman D, Logan M, Crawford K, Chen C, Kundu J, Ebensen T, Guzman CA, Deschatelets L, Krishnan L, Tyrrell DL, Houghton M. Superior immunogenicity of HCV envelope glycoproteins when adjuvanted with cyclic-diAMP, a STING activator.

Identifying enteropathogens in children with acute gastroenteritis presenting with isolated vomiting- APPETITE study. Infectious Diseases Society of America (IDSA): ID Week. San Diego, CA, USA. Lee BE, Pang XL, Zhou R, Parsons B, Chui L, Xie J, Lowerison K, Osterreicher L, Ali S, Freedman S; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE). Detection of enteropathogens in children with acute gastroenteritis presenting with isolated vomiting- APPETITE study.

Canadian Association of Clinical Microbiology and 2017 ImmuNet Research Day. Edmonton, AB, CAN. Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Law J, Logan M, Wong J, Hockman D, Landi A, Chen Meeting. Toronto, ON, CAN. C, Kundu J, Mehta N, Crawford K, Wininger M, Johnson J, Tyrrell DL, Houghton M. Limonta D, Jovel J, Kumar A, Hou S, Airo AM, Branton W, Wong G, Mason A, Power C, Hobman Removal of an immune masking domain, TC. hypervariable region 1 (HVR1) of HCV Astrocytes are a major target for Zika virus glycoprotein E2, does not enhance the replication and persistence in the human fetal immunopogenicity of a glycoprotein-based HCV brain. vaccine. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Le C, Levin A, Fischer K, Addison B, Joyce M, Tyrrell L. Targetting HBV cccDNA. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Le C, Levin A, Tyrrell L. Improving in vitro cell culture infection efficiency of hepatitis B virus. 2017 ImmuNet Research Day. Edmonton, AB, CAN. Lee BE, Pang XL, Zhuo R, Parsons B, Chui L, Xie J, Lowerison K, Osterreicher L, Ali S, Freedman S; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE).

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

American Society for Virology. Madison, WI, USA. Lin YCJ, Evans DH. Compartmentalization of DNA synthesis in vaccinia viral factories. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Lloyd C, Parsons B, Du T, Golding GR, Lee B, Chui L, Freedman S; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE). Clostridium difficile molecular epidemiology in a prospective cohort of Canadian children compared to cases of C. difficile infection. Infectious Diseases Society of America (IDSA): ID Week. San Diego, CA, USA. Logan M, Law J, Wong J, Hockman D, Landi A, Chen C, Kundu J, Crawford K, Wininger M, Johnson J, Houghton M.

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Removal of an immune masking domain hypervariable region 1 (HVR1) of HCV.

Canadian National Perinatal Research Meeting (CNPRM). Montebello, QC, CAN.

6th Canadian Symposium on Hepatitis C Virus. Banff, AB, CAN.

Manz J, Mackova M, Hemmings DG.

Lopez-Orozco J, Pare JM, Hobman TC.

Vasoconstriction by sphingosine 1-phosphate and TNFα: a role in preeclampsia.

Stimulation of membrane receptors reduces RNA interference activity.

Obstetrics and Gynecology Research Day 2017. Edmonton, AB, CAN. Podium presentation.

Stress-Associated RNA Granules in Human Disease and Viral Infection 2nd International Symposium. Heidelberg, DEU.

Mason A, Vincent C, Aspinall A, Swain M, Hirschfield GM, Minuk G, Shah H, Owens-Grillo J, Smoot Malecha E, MacConnell L.

Ma C, Ericson A, Namasopo S, Opoka RO, Conroy A, An integrated analysis of efficacy of Obeticholic Acid in Canadian patients. Hawkes MT. Handheld point-of-care lactate for mortality prediction in Ugandan children with pneumonia. Women and Children’s Health Research Institute (WCHRI) Research Day. Edmonton, AB, CAN. Podium presentation.

CDDW Annual Meeting. Banff, AB, CAN. McDougall C, Davila A, Mason AR, Alghbli S, Hojanepesov O, Shah D, Mason AL, Tandon P, Abraldes J.

Circulating propionate and splanchnic Ma C, Ericson A, Namasopo S, Opoka RO, Conroy A, vasodilation in cirrhosis. Hawkes MT. CDDW Annual Meeting. Banff, AB, CAN. Handheld point-of-care lactate measurement McLaughlin L, Hernandez C, Kabbani D, Doucette predicts mortality in Ugandan children K, Fuentes S, Cervera C. hospitalized with pneumonia. Impact of CMV infection post-liver American Society of Tropical Medicine and Hygiene transplantation according to CMV serostatus. 66th Annual Meeting. Atlanta, GA, USA. Podium Canadian Association of Clinical Microbiology and presentation. Infectious Diseases (CACMID)/ Association of Magor KE. Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. JAMMI 2017; 2:59. Antiviral defenses in the reservoir host of influenza. Mian Q, Conroy A, Opoka RO, Namasopo S, National Poultry Roundtable Paper. Hawkes MT. Manz J, Hemmings DG. Sphingosine 1-phosphate and increased vasodilation in pregnancy. Society for Reproductive Investigation. Orlando, FL, USA. Reproductive Sciences 2017; 24 (1): 285A. Manz J, Mackova M, Hemmings DG. Sphingosine 1-phosphate mediated vascular adaptations and the impact of TNFα on vascular tone in pregnancy.

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Cost-effectiveness of solar-powered oxygen delivery in low resource settings. American Society of Tropical Medicine and Hygiene 66th Annual Meeting. Baltimore, MD, USA. Mocanu V, Brophy J, Kakkar F, Bitnun A, Samson L, Read S, Dieumegard H, Soudeyns H, Hawkes MT; Early Pediatric Initiation of Combination Antiretroviral Therapy, Canada Child Cure Cohort Study (EPIC4).

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Abstracts and Presentations

Lipopolysaccharide binding protein is inversely correlated with endothelial activation markers in vertically HIV-1 infected children. Women and Childrenâ&#x20AC;&#x2122;s Health Research Institute (WCHRI) Research Day. Edmonton, AB, CAN. Podium presentation. Mocanu V, Brophy J, Kakkar F, Bitnun A, Samson L, Read S, Dieumegard H, Soudeyns H, Hawkes MT; Early Pediatric Initiation of Combination Antiretroviral Therapy, Canada Child Cure Cohort Study (EPIC4).

NF, Lindor KD, Zachou K, Poupon R, Trivedi PJ, Carbone M, Verhelst X, Gulamhusein A, Hansen BE. Increase in age at diagnosis of primary biliary cholangitis over the last 40 years. EASL Annual Meeting. Amsterdam, NLD. Journal of Hepatology 2017; 66: S380. Nagata LP, Hu W.-G., Steigerwald R, Kalla R, Irwin C, Umer B, Shenouda M, Lin J, Evans D. Vaccinia vaccines to biological threat and emerging viruses.

Intestinal fatty acid binding protein is associated with increased endothelial activation in vertically HIV-1 infected children.

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN.

Faculty of Medicine and Dentistry Summer Student Research Day. Edmonton, AB, CAN.

Nguyen HH, Aziz Shaheen A, Urbanski SJ, Fritzler MJ, Mason A, Swain MG.

Moctezuma-Velazquez C, Montano-Loza A, Mason A, Nilsson J, Abraldes J.

Development of a multivariate model using serum biomarkers to better define primary biliary cholangitis (PBC)- autoimmune hepatitis (AIH) overlap syndrome.

Validation of Baveno VI criteria for triaging patients for screening endoscopy in primary biliary cholangitis and primary sclerosing cholangitis.

EASL Annual Meeting. Amsterdam, NLD. Journal of Hepatology 2017; 66: S384.

AASLD Annual Meeting. Washington, DC, USA. Hepatology 2017; 66(1): S250A.

Nguyen HH, Shaheen AM, Urbanski S, Fritzler MJ, Mason AL, Swain M.

Montano-Loza A, Hansen B, Roccarina D, Thorburn D, Trivedi P, Hirschfield G, Corpechot C, Poupon R, Dumortier J, Bosch A, Giostra E, Calmus Y, Pares A, Reig A, Franceschet I, Floreani A, Goet J, Harms M, van Buuren H, Van den Ende N, Nevens F, Verhelst X, Donato M, Malinverno F, Mason A.

Can novel serological markers be used to better define primary biliary cholangitis- autoimmune hepatitis overlap syndrome.

Recurrence of primary biliary cholangitis after liver transplantation affects graft survival: a multi-center study from the Global PBC Study Group.

Construction of infectious orthopoxviruses from chemically synthesized DNA fragments for use as novel oncolytic viruses.

AASLD Annual Meeting. Washington, DC, USA. Hepatology 2017; 66(1): S163A. Murillo Perez CF, Lammers WJ, Goet JC, Janssen HL, van Buuren HR, Mason A, Corpechot C, Invernizzi P, Mayo MJ, Battezzati PM, Floreani A, Pares A, Nevens F, Kowdley KV, Ponsioen CY, Bruns T, Dalekos GN, Thorburn D, Hirschfield G, LaRusso

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

CDDW Annual Meeting. Banff, AB, CAN. Noyce R, Desaulniers M, Lederman S, Evans D.

Summit for Cancer Immunotherapy. Gatineau, QC, CAN. Noyce R, Desaulniers M, Lederman S, Evans D. Construction of infectious orthopoxviruses from chemically synthesized DNA fragments for use as novel oncolytic viruses. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference.

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Edmonton, AB, CAN. Noyce R, Desaulniers M, Lederman S, Evans D. Construction of infectious orthopoxviruses from chemically synthesized DNA fragments for use as novel oncolytic viruses. Cancer Research Institute of Northern Alberta. Edmonton, AB, CAN. O’Neil C, Cooper R, Doucette K, Long R. Tuberculosis after lung transplantation: safety and efficacy of rifabutin based treatment in the setting of transplant immunosuppression. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. JAMMI 2017; 2:52.

High genetic variability of norovirus leads to diagnostic test challenges. Infectious Diseases Society of America (IDSA): ID Week. San Diego, CA, USA. Parsons B, Freedman SB, Xie J, Nettel-Aguirre, Lee B, Chui L, Pang XL, Zhou R, Dickinson JA, Vanderkooi O, Ali S, Osterreicher L, Lowerison K, Tarr PI. Enteropathogen detection in children with acute gastroenteritis: a comparison of rectal flocked swabs and stool specimens. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. Podium presentation.

Pabbaraju K, Gill K, Fonseca K, Tipples GA, Tellier R. Preiksaitis JK, Mabilangan C, Burton C, Urschel S. Detection of Zika, Chikungunya and Dengue viruses in returning travelers to Alberta, Canada. ASM Clinical Virology Symposium. Savannah, GA, USA. Pang XL, Hasing E, Qiu Y, Tipples G, Lee BE. Norovirus outbreak in Alberta Canada- which strain will win the Indy race? Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. Podium presentation. Pang X, Tong Y, Preiksaitis JK. Highly fragmented CMV DNA in the plasma of solid organ transplant recipients interferes with quantitative CMV viral load measurement and inter-assay result harmonization.

Torque Teno Virus (TTV) and Epstein-Barr Virus (EBV) viral load in peripheral blood as a biomarker of “net immunosuppression”: factors influencing viral load in adult patients awaiting solid organ transplantation. Infectious Diseases Society of America (IDSA): ID Week. San Diego, CA, USA. 2017; 4(1): S701. Preiksaitis JK, Mabilangan C, Cervera C. Impact of cytomegalovirus and its prevention strategies on survival in thoracic transplant recipients. International Society for Heart & Lung Transplantation. San Diego, CA, USA. J Heart Lung Transplant 2017; 36(4S): 41. Qiu Y, Pang XL. Toxic cyanobacteria monitoring in Alberta lakes from 2012-2016.

2017 SoGATS workshop. London, GBR. Podium presentation.

DRIvE Day in Laboratory Services & Pathology. Edmonton, AB, USA.

Pang XL, Zhuo R, Qui Y, Parsons B, Lee B, Chui L, Freedman S; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE).

Rahbari M, Sharon D, Houghton M, Mason A.

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Identification of an immunosuppressive domain in human betaretrovirus Env.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Abstracts and Presentations

CDDW Annual Meeting. Banff, AB, CAN. Remington L, Osman M, Simmonds K, Charlton C, Doucette K. Quality of assessment and linkage to care for newly diagnosed chronic hepatitis B patients. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. JAMMI 2017; 2:10. Podium presentation. Rezaeeaval M, Sumner S, Shafran S, Doucette K. Treatment outcome in chronic hepatitis C genotype 1 patients treated with 8 weeks vs. 12 weeks of Ledipasivir/Sofosbuvir based on viral load criteria as determined using the Abbot real time assay. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. JAMMI 2017; 2:11. Podium presentation. Rojas Vasquez M, Desai S, Peters A, Preiksaitis JK, Urschel S, Lai R, Yap J, Morgan C. Monomorphic post transplant lymphoproliferative disorder (diffuse large B cell lymphoma subtype) successfully treated without chemotherapy after solid organ transplant in children. The American Society of Hematology. San Diego, CA, USA. Santer DM, Minty GES, Mohammed A, Baldwin L, Bhat R, Joyce M, Egli A, Tyrrell DLJ, Houghton M. A novel method for detecting IFN-lambda 3 binding to cells to quantify IFN-lambda receptor expression on hepatocytes and immune cell subsets. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Santer DM, Minty GES, Mohammed A, Baldwin L, Bhat R, Joyce M, Egli A, Tyrrell DLJ, Houghton M.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

A novel method for detecting IFN-lambda 3 binding to cells to quantify IFN-lambda receptor expression on hepatocytes and immune cell subsets. 2017 ImmuNet Research Day. Edmonton, AB, CAN. Santer DM, Minty GES, Mohammed A, Baldwin L, Bhat R, Joyce M, Egli A, Tyrrell DLJ, Houghton M. A novel method for detecting IFN-lambda 3 binding to cells to quantify IFN-lambda receptor expression on hepatocytes and immune cell subsets. 30th Annual Canadian Society for Immunology (CSI) Conference. Banff, AB, CAN. Santer DM, Minty GES, Mohammed A, Baldwin L, Bhat R, Joyce M, Egli A, Tyrrell DLJ, Houghton M. A novel method for detecting IFN-lambda 3 binding to cells to quantify IFN-lambda receptor expression on epithelial and immune cell subsets. American Association of Immunologists (AAI) Annual Meeting. Washington, DC, USA. Shen Y, Russo V, Zeglinski M, Sellers S, Wu ZG, Oram C, Santacruz S, Merkulova Y, Tumer C, Tauh K, Zhao HY, Bozin T, Bohunek L, Zeng HS, Seidman M, McManus B, Bleackley RC, Ruosiahti E, Jarvinen TA, Granville D. Systemic administration of target-seeking, vessel penetrating recombinant decorin fusion protein, Car-DCN, reduces severity of abdominal aortic aneurysm in mice. Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference. Minneapolis, MN, USA. Arteriosclerosis, Thrombosis, and Vascular Biology 2017; 37:A487. Srigley JA, Prelude L, Thampi N, Vayalumkal J, Amaratunga K, Bush K, Collet JC, Ellis C, Embree J, Forrester L, Frenette C, Henderson E, Johnston JM, Langley J, Lee B, Lefebvre MA, Lemieux C, McGeer A, Noseworthy E, Quach C, Richardson S, Science M, Smoth S, So J, Suh K, Taylor G; Canadian Nosocomial Infection Surveillance Program (CNISP).

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Central line-associated bloodstream infections in Canadian pediatric and neonatal intensive care units: 2009-2015. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. Steenbergen R, Oti M, ter Horst R, Tat W, Neufeldt C, Belovodskiy A, Chua TT, Cho WJ, Joyce MA, Dutilh BE, Tyrrell DL.

Tennankore K, Doucette K, Kiberd B. Use of hepatitis C infected organs for kidney transplantation: a medical decision analysis. American Transplant Congress Conference. Chicago, IL, USA. Am J Transplant 2017; 17 (S3): 379. Podium presentation. Tennankore K, Doucette K, Kiberd B. Use of hepatitis C infected organs for kidney transplantation: a cost-effective analysis.

Metabolic reprogramming in Huh7.5 cells cultured in human serum.

American Transplant Congress Conference. Chicago, IL, USA. Am J Transplant 2017; 17 (S3): Bridging Discovery Research with Therapies. Banff, 807. AB, CAN. Podium presentation. Tennankore K, Doucette K, Kiberd B. Storozynsky Q, Evans D, Potts K, Agopsowicz K, Treating hepatitis C+ patients before or after Godbout R, Fung R, Hitt M. kidney transplantation: a medical decision Combining oncolytic vaccinia virus therapy with image-guided radiotherapy for tumor treatment in preclinical glioma models. 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Tat W, Steenbergen R, Tyrrell DL. Lipid metabolism in relation to development of steatosis in hepatitis C virus infected hepatocytelike cells.

analysis.

American Transplant Congress Conference. Chicago, IL, USA. Am J Transplant 2017; 17 (S3): 265. Podium presentation. Turnbull H, Kasereka MC, Amirav I, Sahika SE, Solomon I, Aldar Y, Hawkes MT. Development of the Respimometerâ&#x201E;˘, a novel device for objective respiratory rate measurement in low resource settings.

Women and Childrenâ&#x20AC;&#x2122;s Health Research Institute 7th Annual Global Health Fair. Edmonton, AB, CAN. (WCHRI) Research Day. Edmonton, AB, CAN. Podium presentation. Tat W, Steenbergen R, Tyrrell DLJ. Tuszynski JA, Santelices I, Friesen DE, Bell C, Xiao J, Lipid metabolism in relation to development of Rezania V, Freedman H, Hough CM, Tsung AJ, steatosis in hepatitis C virus infected hepatocyteVelpula KK, Shankar K. like cells. Response to alternating electric fields of 2017 ImmuNet Research Day. Edmonton, AB, CAN. microtubule ensembles in electrolytic solution. Tat W, Steenbergen R, Tyrrell DLJ. American Association of Cancer Research (AACR) Lipid metabolism in relation to development of Annual congress. Washington, DC, USA. steatosis in hepatitis C virus infected hepatocyteUmer B, Noyce R, Lin J, Desaulniers M, Favis N, like cells. Kelly R, Hitt M, Evans D. 3rd Li Ka Shing Institute of Virology & Gairdner Reprogramming the tumour microenvironment Symposium, Alberta Virology Conference. with modified vaccinia viruses. Edmonton, AB, CAN.

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LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Abstracts and Presentations

Cancer Research Institute of Northern Alberta Research Day. Edmonton, AB, CAN. Umer B, Noyce R, Rans K, Middleton J, Hitt M, Evans D. Combining oncolytic vaccinia virus immunotherapy with targeted image-guided radiation improves breast cancer regression in syngeneic tumour models. Summit for Cancer Immunotherapy 2017. Gatineau, QC, CAN. Umer B, Noyce R, Rans K, Middleton J, Hitt M, Evans D. Combining oncolytic vaccinia virus immunotherapy with targeted image-guided radiation improves breast cancer regression in syngeneic tumour models.

Quach C, Richardson S, Science M, Simor A, Smith S, So J, Srigley JA, Stagg P, Thampi N; Canadian Nosocomial Infection Surveillance Program (CNISP). Methicillin-resistant Staphylococcus aureus (MRSA) infections in hospitalized pediatric patients in Canada 2008-2015. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID)/ Association of Medical Microbiologists of Canada (AMMI) Meeting. Toronto, ON, CAN. Wasilenko S, Lytvyak E, Montano-Loza AJ, Mason AL. Elevated biochemical liver tests within 1-year transplant predicts recurrent PSC. CDDW Annual Meeting. Banff, AB, CAN.

2017 ImmuNet Research Day. Edmonton, AB, CAN. Wasilenko S, Montano-Loza A, Lytvyak E, Tsochatzis ET, Ravikumar R, Jose S, Allison M, Van der Meer A, Harms M, Corpechot C, Thorburn Gunson B, Manas D, Monaco A, Mirza D, Fusai G, D, Lammers W, Invernizzi P, Janssen H, Battezzati Owen N, Thorburn D, Roberts K, Srinivasan P, P, Nevens F, Lindor K, Floreani A, Ponsioen C, Mayo Wigmore S, Burroughs S, Athale A, Creamer F, M, Pares A, Mason A, Kowdley K, Hirschfield G, van Fernando B, Lyer V, Madanur M, Sen G, Mason A. Buuren H, Hansen B; on behalf of the Global PBC Elevated hepatic biochemistry predicts recurrent Study Group. primary sclerosing cholangitis in the first 12 Ursodeoxycholic Acid is associated with a months following liver transplantation. prolonged transplant-free survival in all patients AASLD Annual Meeting. Washington, DC, USA. with primary biliary cholangitis- there is no such Hepatology 2017; 66(1): S159A. thing as non-response. AASLD Annual Meeting. Washington, DC, USA. Hepatology 2017; 66(1): S155A. Vanderkooi OG, Xie J, Lee B, Ali S, Pang XL, Chui L, Payne DC, Tarr P, Zhuo R, Parsons B, Osterreicher L, Kim K, Freedman S.

Wong GK. 10KP: sequencing the genomes of 10,000 phylodiverse plant species. China National Gene Bank. Shenzhen, CHN.

Gastroenteritis severity: a retrospective cohort comparison of children in emergency department and home settings.

Wong GK.

Infectious Diseases Society of America (IDSA): ID Week. San Diego, CA, USA.

XIX International Botanical Congress. Shenzhen, CHN.

Vayalumkal JV, Pelude L, Lee B, Amaratunga K, Durand J, Embil J, Embree J, Forrester L, Frenette C, Gittens C, Golding G, Ivany A, Katz K, Kibsey P, Langley JM, Lefebvre MA, McGeer A, Ormiston D,

Wong GK.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

Large-scale sequencing of biodiverse plants: beyond model organisms and crop species.

Biodiversity for optogenetics: mammalian neuroscience applications of algal proteins.

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XIX International Botanical Congress. Shenzhen, CHN. Wong GK. Omic databases and their role in clinical decision making. Personalized Medicine Summit. University of British Columbia, Vancouver, BC, CAN. Wu J, Ingham R. Identification of genes regulated by the JunB transcription factor in ALK+ ALCL. 8th Annual Meeting of the European Research Initiative for ALK-Related Malignancies (ERIA). Cambridge, GBR. Podium presentation. Wu J, Ingham RJ. The function of JunB in the pathobiology of ALK+ ALCL.

Role of autotaxin and inflamed mammary adipose tissue in the development of doxorubicin resistance in breast cancer. Obstetrics and Gynecology Research Day 2017. Edmonton, AB, CAN. Yao Q, Fischer KP, Tyrrell DL, Gutfreund KS. Expression and characterization of soluble Pekin duck Programmed Death-1. Canadian Association of Gastroenterology (CAG) and the Canadian Association for the Study of the Liver (CASL) Canadian Digestive Diseases Week. Banff, AB, CAN. Yoshida EM, Fischer A, Mason A, Shah H, Pelekian KM, Hux M, Thiele SL, Borrelli R. Prevalence of primary biliary cholangitis in Canada: first national study.

CDDW Annual Meeting. Banff, AB, CAN. 2017 ImmuNet Research Day. Edmonton, AB, CAN. Yoshida EM, Thiele SL, Mason A, Peltekian K, Wong Podium presentation. P, Hux M, Fischer A, Borrelli R. Wu J*, Zhang J*, Yang M, Savin A, Bacani J, Ingham The current state of liver transplantation in RJ. Canada. The function of AP-1 transcription factors in the EASL Annual Meeting. Amsterdam, NLD. Journal proliferation of CD30+ lymphomas. of Hepatology 2017; 66: S495. 30th Canadian Student Health Research Forum/ Zhou R, Lee B, Parsons B, Crago B, Drews S, Chui L, Gairdner Symposium. Winnipeg, MB, CAN. * coLouie M, Freedman SB, Pang XL; Alberta Provincial authors. Pediatric EnTeric Infection TEam (APPETITE). Wysokinski F, Meng B, Wang W, Wong I, Bitner J, Flocked oral swabs to identify viral pathogens in McDougall C, Wasilenko S, Hosamani I, Sharon D, children with acute gastroenteritis. Zwingmann C, Michelakis E, Sutendra G, Mason A. DRIvE Day in Laboratory Services & Pathology. Cholangiocytes from patients with primary biliary Edmonton, AB, USA. cholangitis display the Warburg Effect with increased mitochondria, oxygen consumption and Zhou R, Parsons B, Lee B, Chui L, Freedman S, Ali S, glycolytic activity. Lowerison K, Hagen E, Pang XL; Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE). AASLD Annual Meeting. Washington, DC, USA. Hepatology 2017; 66(1): S933A. Alberta Provincial Pediatric EnTeric Infection Team (APPETITE): identifying pathogens Yang Z, Venkatraman G, Tang X, Benesch MGK, responsible for pediatric acute gastroenteritis Parissenti AM, McMullen TPW, Brindley DN, through enhanced detection. Hemmings DG.

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Abstracts and Presentations

3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference. Edmonton, AB, CAN. Podium presentation.

LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

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MEDIA ENGAGEMENTS David Evans

• “How Canadian researchers reconstituted an extinct poxvirus for $100,000 using mail-order DNA” by Kai Kupferschmidt. Published in Science July 6.

http:/ http://www.sciencemag.org/news/2017/07/how-canadian-researchersreconstituted-extinct-poxvirus-100000-using-mail-orderdna/www.sciencemag.org/news/2017/07/how-canadian-researchersreconstituted-extinct-poxvirus-100000-using-mail-order-dna

• “Synthetic horsepox virus”.

Radio interview for GLZ Radio. Aired July 26.

• Découverte, ICI Radio-Canada Télé interview. Aired August 17.

• “Variole, une resurrection inquiétante” by Yves Sciama. Published in Le Monde.Fr (Sciences) October 31.

http://www.lemonde.fr/sciences/article/2017/10/30/variole-une-resurrectioninquietante_5207923_1650684.html?xtmc=virus_evans&xtcr=1

• “How recreating horsepox in a lab could lead to cancer cures”. CBC Radio interview for Quirks & Quarks with Bob McDonald. Aired December 30.

http://www.cbc.ca/radio/quirks/2017-s-most-incredible-science-stories-wealmost-missed-1.4443493/how-recreating-horsepox-in-a-lab-could-lead-tocancer-cures-1.4443504

Tom Hobman

• “Alberta team granted federal funding to help stop Zika virus” by Su-Ling Goh. Published on Global News March 16. Aired on Global News March 16.

https://globalnews.ca/news/3315620/alberta-team-granted-federal-funding-tohelp-stop-zika/

• “University of Alberta lab continues search for fatal flaw in Zika virus” by Clare Clancy. Published in the Edmonton Journal and the Edmonton Sun March 25.

http://edmontonjournal.com/news/local-news/university-of-alberta-labcontinues-search-for-fatal-flaw-in-zika-virus

• “Study may lead to new diagnostic and prognostic tools for HIV-associated neurocognitive disorders” by Ross Neitz. Published in Folio July 20.

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Media Engagements

https://www.folio.ca/study-may-lead-to-new-diagnostic-and-prognostic-tools-forhiv-associated-neurocognitive-disorders

• “U of A researchers uncover clue to link between HIV, dementia” by Scott Leitch. Published in the Edmonton Journal and the Edmonton Sun July 20. Aired on Global and CTV news July 21.

http://edmontonjournal.com/news/local-news/uofa-researchers-learning-thelink-between-hiv-and-dementia

Michael Houghton • “Michael Houghton’s 30-year quest to cure hepatitis C” podcast by CFI, Ottawa Canada. Posted November 24.

https://www.innovation.ca/story/michael-houghtons-30-year-quest-curehepatitis-c • Media interactions during “World Hepatitis Day Canada” by the Canadian Society for International Health (CSIH). July 24. https://whdcanada.org/

David Marchant

• “An unheralded yet costly flu-like virus to hit the province hard, according to UAlberta research” by Michael Brown. Published in Folio October 26. https://www.folio.ca/an-unheralded-yet-costly-flu-like-virus-to-hit-the-provincehard-according-to-ualberta-research/

• “Severe RSV season ahead for Alberta: researcher” by Caley Ramsay. Published in Global News November 1. Aired on Global National News on November 1. https://globalnews.ca/news/3838373/severe-rsv-season-ahead-for-albertaresearcher/ • Television interview with Shawna Randolph for CTV News Alberta Prime Time at Five. Aired on CTV October 30.

Jack Tuszynski • “Consciousness depends on tubulin vibrations inside neurons, anesthesia study suggests”. Published on Newswise September 5. https://www.newswise.com/articles/consciousness-depends-on-tubulinvibrations-inside-neurons-anesthesia-study-suggests

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• “Are there optical communication channels in our brains” by Emerging Technology from the arXiv. Published in MIT Technology Review September 6. www.technologyreview.com/s/608797/are-there-optical-communicationchannels-in-our-brains/ • “How consciousness could live in your brain cells” by Michael Brown. CBC Radio interview for Quirks & Quarks with Bob McDonald. Aired December 2. http://www.cbc.ca/radio/quirks/how-consciousness-could-live-in-your-braincells-1.4424508/how-consciousness-could-live-in-your-brain-cells-1.4424544

Stephanie Yanow

• “Discovery may lead to more effective malaria vaccine” by Nisa Drozdowski. Published in University of Alberta School of Public Health News April 25. https://www.ualberta.ca/public-health/news/2017/april/discovery-may-lead-tomore-effective-malaria-vaccine

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SPIN-OFF COMPANIES Critical to the mandate of the Li Ka Shing Institute of Virology is the commercialization of products beneficial to human health. Research undertaken by Li Ka Shing Institute of Virology members resulted in the formation of two spin-off companies in 2017. Antibiddies Technologies Inc.

Aurora Vaccines Inc.

Developed to license research derived products

Developed to commercialize a vaccine for hepatitis C

These companies are in addition to the following four companies previously formed: Prophysis Inc. Development of a broad spectrum of antiviral drugs and cancerfighting agents. Products include computer-assisted processes to develop new antivirals and analyze drug toxicity. (Formed 2012) Achlys Inc. In silico cardiac ion channel drug screening. Development and commercial sale of a novel human ventricular cardiomyocyte cell line. (Formed 2014) Heka Therapeutics Inc. A spin-off company from the Applied Virology Institute for the research, development, and commercialization of small molecule immunomodifiers to treat cancer and chronic infections. (Formed 2015) Aurora Vaccines (Formed 2016) The development and formation of six spin-off companies in the seven years following the establishment of the Li Ka Shing Institute of Virology highlights the quality and applicability of the research within the Institute and indicates the dedication of the Institute towards the translation of research discoveries to products that benefit society.

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PATENTS Inhibition of GSK3.BETA as a therapy for Zika, Dengue and West Nile viruses Sarahan MA, Mason A, Hobman T USPTO 62/481,472 04/04/2017

pCMV6-FcV2-S N and C terminal Fc-fusion vector Griffith C, Marchant D

Biomarkers in autoimmune liver disease Landi M, Bonino F, Montano-Loza A, Clementin A, Tyrrell D, Houghton M USPTO 62/571,034 11/10/2017

Systems and methods of selecting compounds with reduced risk of cardiotoxicity using cardiac sodium ion channel models Barakat K, Ahmed M, Ganesan A, Tyrrell DL, Houghton M USPTO 15/699,843

RIG-I promoter and compositions and methods relating to same Xiao Y, Magor KE USA UALB-037PRV 01/09/2017

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Cross-reactive malaria protein, antibodies thereto and methods of use Yanow S, Gnidehou S, Good M Australia 20179018225 16/05/2017

Use of peroxisome biomarkers for predicting HIV disease progression and for treatment with peroxisome activating drugs Hobman T, Power C, Xu Z USPTO 62/503,182 08/05/2017

Anesthetic induced alterations in london dispersion interactions in tubulin correlated with their potency implying a novel mode of action Craddock T, Hameroff SR, Tuszynski JA 7/06/2017

Mutant vaccinia virus strains, uses thereof and methods of producing the same Qin L, Liang M, Evans DH PCT/CN2013/074028 Filed: China, Japan, and others Issued: US Patent #9,765,305 B2 19/09/2017

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Collaborating Institutes

COLLABORATING INSTITUTES

Canada

Faculty of Agricultural Life and Environmental Sciences Department of Agricultural Food and Nutritional Science

Centre de Recherché du CHUM, Montreal QC Dalhousie University, Halifax NS

Faculty of Engineering

McGill University, Montréal QC

Faculty of Law Health Law Institute

University of British Columbia, Vancouver BC

University of Alberta

Faculty of Medicine & Dentistry Department of Biochemistry

Canadian Food Inspection Agency (CFIA), Winnipeg MB

INRS-Institut Armand Frappier, Laval QC McMaster University, Hamilton ON University of Calgary, Calgary AB Université de Montréal, Montréal QC

Department of Cell Biology

University of Toronto, Toronto ON

Department of Dentistry

United States of America

Department of Medical Microbiology and Immunology Department of Medicine Division of Gastroenterology Department of Obstetrics and Gynecology Department of Oncology Department of Pediatrics Department of Pharmacology Department of Surgery

Arcadia Biosciences, Davis CA

Baylor College of Medicine, Houston TX Center for Infectious Disease Research, Seattle WA Chicago Botanic Garden, Glencoe IL Chimerix, Durham NC Cornell University, Ithaca NY Donald Danforth Plant Science Center, St. Louis MO

Faculty of Pharmacy and Pharmaceutical Sciences

Duke University, Durham NC

Faculty of Science Department of Biological Sciences Department of Chemistry

Florida Museum of Natural History, Gainesville FL

School of Public Health Women & Children’s Health Research Institute (WCHRI)

Edmonton Alberta

Boyle McCauley Health Centre ContraVir Pharmaceuticals

Eastern Kentucky University, Richmond KY

Fred Hutchinson Cancer Research Center, Seattle WA Harvard University, Cambridge MA Institute for Systems Biology, Seattle WA iPlant Collaborative, Tucson AZ Massachusetts Institute of Technology (MIT), Cambridge MA

Institute of Health Economics

National Institutes of Health Research (NIH), Bethesda MD

Provincial Laboratory for Public Health (ProvLab)

New York Botanical Garden, New York NY

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New York University School of Medicine, New York NY

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North Carolina State University, Raleigh NC Northeastern University, Nahant MA Northwestern University, Evanston IL Nova Southeastern University, Broward County FL Ocean Genome Legacy Inc., Ipswich MA

Belgium

Rega Institute for Medical Research, Leuven

Benin

Ohio State University, Columbus OH

Institut de Recherche pour le Développement, Cotonou

Pennsylvania State University, University Park PA

Brazil

Rockefeller University, New York NY

FIOCRUZ Instituto Oswaldo Cruz, Rio de Janeiro

Rutgers University, Piscataway NJ

China

Stanford University, Stanford CA Tonix Pharma, New York NY United States Department of Agriculture (USDA) Exotic & Emerging Avian Viral Diseases Research, Athens GA

Beijing Institute of Genomics (BIG) Chinese Academy of Sciences, Beijing Beijing Genomics Institute (BGI), Shenzhen Fairy Lake (Xianhu) Botanical Garden, Shenzhen

University of Arizona, Tucson AZ

Heilongjiang Academy of Agricultural Sciences, Harbin

University of Arizona Phoenix, Phoenix AZ

Ocean University of China, Qingdao

University of California Davis, Davis CA University of California San Diego, La Jolla CA University of Chicago, Chicago IL University of Connecticut, Mansfield CT University of Florida, Gainesville FL University of Georgia, Athens GA University of Michigan, Ann Arbor MI University of Missouri, Columbia MO University of Southern Florida, Tampa FL University of Tennessee, Knoxville TN

Columbia

Universidad de Antioquia, Medellín

Denmark

Copenhagen University Hospital, Copenhagen University of Copenhagen, Copenhagen

Finland

University of Helsinki, Helsinki

France

University of Texas, Austin TX

CNRS, Toulouse

University of Texas Medical Branch, Galveston TX

CNRS- Station d’Ecologie Théorique et Expérimentale, Moulis

University of Washington, Seattle WA

Eukarӱs SAS, Ile-De-France

University of West Virginia, Morgantown WV

Université Paris Descartes, Paris

Australia

Germany

Australian National University, Canberra ACT Griffith University, Southport QLD

Helmholtz Centre for Infection Research, Braunschweig

University of Queensland, Brisbane QLD

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Collaborating Institutes

Ludwig-Maximilians-Universität München, Munich Max Planck Institute of Molecular Plant Physiology, Potsdam Max Planck Institute for Ornithology, Radolfzell University of Cologne, Cologne University of Konstanz, Konstanz

Ghana

Kwame Nkrumah University of Science and Technology, Kumasi

Sweden

Karolinska Institutet, Solna

Switzerland SUPSI, Manno

Université de Lausanne, Lausanne University Hospital of Zürich, Zürich

Uganda

University of Ghana, Accra

Ministry of Health, Kampala

Ireland

United Kingdom

University College Cork, Cork

Italy

Royal Botanic Gardens, Kew University of Cambridge, Cambridge

Polytechnic University of Turin, Turin University of Bologna, Bologna

Japan

University of Tsukuba, Tsukuba

Netherlands

Radboud University Medical Centre (Radboudmc), Nijmegen

Phillipines

International Rice Research Institute (IRRI), Los Baños

Poland

University of Poznań, Poznań

Singapore

Genome Institute of Singapore, Singapore

South Africa

Central University of Technology, Bloemfontein

Spain

Real Jardin Botanico, Madrid

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COLLABORATIONS

Li Ka Shing Institute of Virology

The Li Ka Shing Institute of Virology is primarily associated with the Department of Medical Microbiology and Immunology at the University of Alberta, however, its members are affiliated with 14 Departments and Faculties at the University of Alberta

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Li Ka Shing Institute of Virology Members have collaborators in:

18 Departments or Institutes at the University of Alberta; 14 Institutes within Canada; and 90 Institutes in 25 countries around the world! Countries with Institutions that collaborate with Li Ka Shing Institute of Virology Members are highlighted in green on the world map. LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

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RESEARCH EXCELLENCE

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CONGRATULATIONS TO OUR 2017 AWARD RECIPIENTS! David Evans

TEC Edmonton “Innovation… Makes Sense” Patent Prize

David Marchant

Fellow of the Royal Society of Medicine

Maya Shmulevitz

CRC Tier II Chair in Molecular Virology and Oncotherapy

Gane Ka Shu Wong

Faculty of Applied Science Medal of Distinction (University of British Columbia)

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TRAINEE AWARDS (awarded or held in 2017) Adriana Airo

Canadian Institutes of Health Research (CIHR) Doctoral Research Award

Lee Campbell

Alberta Innovates Technology Futures Award

Rhianna Charchuk

Women and Childrenâ&#x20AC;&#x2122;s Health Research Institute (WCHRI) Graduate Studentship

Tim Cho

Office of the Provost and VP (Academic) Summer Research Award

Francisca Cristi

Best poster presentation award, Alberta Virology Conference 75th Anniversary Graduate Student Award, Faculty of Medicine & Dentistry

Powel Crosley

75th Anniversary Graduate Student Award, Faculty of Medicine & Dentistry

Jianing Dong

Faculty of Medicine & Dentistry/ Alberta Health Services Graduate Student Recruitment Studentship 75th Anniversary Graduate Student Award, Faculty of Medicine & Dentistry Alberta Innovates Graduate Student Scholarship

Yuliya Fakhr

Maternal Child Health Graduate Program (MatCH)

David Fast

Alberta Innovates Graduate Student Scholarship, Doctoral

Meghan Ferguson

Faculty of Medicine & Dentistry/ Alberta Health Services Graduate Student Recruitment Studentship Alberta Innovates Graduate Student Scholarship

Jason Fernandez

Alberta Innovates Graduate Student Scholarship, Doctoral

Anthony Galenza

Natural Sciences and Engineering Research Council of Canada (NSERC) Create Host- Parasite Interactions Network Scholarship

Ken Gavina

Natural Sciences and Engineering Research Council of Canada (NSERC) Create Host- Parasite Interactions Network Scholarship

Dominic Golec

Alberta Innovates Health Solutions (AIHS) Studentship

Cameron Griffiths

Canadian Lung Association Grant

Donald Grynoch

Alberta Transplant Institute Undergraduate Summer Studentship

Patrick Guo

China Scholarship Council (CSC) Scholarship

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Shangmei Hou

Women and Children’s Health Research Institute (WCHRI) Graduate Studentship

Janelle Johnson

Queen Elizabeth II Graduate Scholarship, M.Sc. Level

Anil Kumar

Alberta Innovates Health Solutions (AIHS) Postgraduate Fellowship

Connie Le

Alberta Innovates Health Solutions (AIHS) MD/PhD Graduate Studentship

Daniel Limonta

Alberta Innovates Health Solutions (AIHS) Postgraduate Fellowship

Cary Ma

1st Place medical student presentation, Women and Children’s Health Research Institute (WCHRI) Research Day

Angie Mena

COLCIENCIAS Scholarship

Qaasim Mian

Benjamin H. Kean Travel Fellowship in tropical medicine AMMI Canada “Incubator” for solar powered oxygen delivery

Katie Mitran

Natural Sciences and Engineering Research Council of Canada (NSERC) Scholarship, Ph.D. Level

Victor Mocanu

Alberta Innovates Health Solutions (AIHS) Summer Studentship

Karl Roesner

75th Anniversary Graduate Student Award, Faculty of Medicine & Dentistry

Brett Roughead

75th Anniversary Graduate Student Award, Faculty of Medicine & Dentistry

Natasha Saik

University of Alberta Doctoral Recruitment Scholarship

Natalie Snyder

Office of the Provost and VP (Academic) Summer Research Award

Quinn Storozynsky

Canadian Institutes of Health Research (CIHR) Canada Graduate Scholarship, Master’s

Iryna Stryapunina

Women and Children’s Health Research Institute (WCHRI) Summer Studentship Biomedical Global Health Research Network (BGHRN) Incentive Award Alberta Innovates Health Solutions (AIHS) Summer Studentship

Jason Wong

Alberta Innovates Graduate Studentship

Kang Yu

China Scholarship Council (CSC) Scholarship

Young Zhou

Office of the Provost and VP (Academic) Summer Research Award

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SPONSORSHIP

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GRANT AWARD PROGRAMS The Li Ka Shing Institute of Virology established a regular process of grant awards in 2011. This successful program assists Li Ka Shing Institute of Virology members with “proof-of-principal”, “translational”, and “rapidresponse” awards. The goal of this award program is to produce intellectual properties (IPs) that pertain to the Li Ka Shing Institute of Virology’s mission to support virology research and human health. The proof-of-principal award enables Li Ka Shing Institute of Virology researchers to explore leads that show promise for creating IP with eventual translation into practical applications. The translational award supports the translation of IP into clinical practice. The rapid response award provides immediate funds. These awards are in addition to Li Ka Shing Institute of Virology Start-Up support provided for New Investigators. In 2017, the Li Ka Shing Institute of Virology awarded three new proof-ofprincipal awards to the sum of $150,000, and provided a second year of support for three proof-of-principal awards to the sum of $150,000.

Since the inception of the Award Programs, the Li Ka Shing Institute of Virology has supported its members with $2,617,826.

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Newly Awarded or Continuing Proof-of-Principal Awards Harnesssing the cGAS/STING pathway to enhance vaccination and viral oncolysis James Smiley (PI) 2017- 2018

$50,000

Cross-species epitopes as candidate vaccines against placental malaria Stephanie Yanow (PI), Khaled Barakat (collaborator) 2017- 2018

$50,000

Influenza resistant chickens expressing duck RIG-I Katharine Magor (PI) 2017- 2018

$50,000

Unmet need: a molecular tool to detect the puromycin resistance gene Maya Schmulevitz and Rob Ingham (Co-Is) 2016- 2018

$100,000 In vivo validation of novel reovirus variants for superior oncolytic therapy Maya Schmulevitz (PI), Mary Hitt (Co-I) 2016- 2018

$100,000 Development of anti-CMV inhibitors Matthias Gรถtte (PI) 2016- 2018

$100,000

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EDUCATIONAL EVENT SPONSORSHIP In 2017, the Li Ka Shing Institute of Virology supported educational activities with donations of: $15,000 towards the 3rd Li Ka Shing Institute of Virology & Gairdner Symposium, Alberta Virology Conference; $ 7,167 towards the ImmuNet Retreat and ImmuNet Seminar Series; $ 5,000 towards a visit and seminar by Dr. Janet Rossant, an internationally renowned developmental biologist awarded the Friesen Prize by the Friends of Canadian Institutes of Health Research (FCIHR) in 2016; $ 1,000 towards the University of Alberta Postdoctoral Fellows Association Annual Research Day.

The 3rd Li Ka Shing & Gairdner Symposium, Alberta Virology Conference was a great success, attended by 193 individuals from 23 institutes across Alberta and the world!

Since 2011, the Li Ka Shing Institute of Virology has supported educational activities at the University of Alberta with $178,716 in donations! LEADING THE WORLD IN VIROLOGY DISCOVERIES AND CURES

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SPONSORED SEMINARS ImmuNet Seminar Series- External Speakers Dr. Lisa Barrett

Modeling immune aging through chronic viral infection: lessons from curing Hepatitis C. (Jan. 19)

Clinical Scientist, Division of Infectious Diseases, Dalhousie University.

Dr. Joyce Wilson

HCV replication promotion by miR-122, Argonaute, and other small RNAs. (Feb. 16)

Professor, Department of MMI, University of Saskatchewan.

Dr. Selena Sagan

Host-virus interactions in hepatitis C and Zika virus infection. (April 27)

Assistant Professor, Department of Microbiology & Immunology, McGill University.

Dr. John Patton

Rotavirus evasion of the innate immune response: a tale of deception and destruction. (May 25).

Associate Professor, Department of Veterinary Medicine, University of Maryland.

Dr. Jayne Danska

Complex causes of autoimmune disease: genes, environment and microbes. (June

14). Professor and Senior Scientist, Hospital for Sick Children Research Institute, University of Toronto.

Constraining Evolution- Avoiding Drug Resistance: Lessons from Viruses. (Oct. 5) Professor, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School.

Dr. Celia A Schiffer

ImmuNet Seminar Series- Internal Speakers Dr. Gregory Tyrrell

Invasive Group B streptococcal disease in Alberta. (Feb. 2)

Professor, Department of Laboratory Medicine & Pathology, University of Alberta.

Dr. Nicholas Ashbolt

The microbiota and pathogen control of your household plumbing. (Feb. 7)

Professor, School of Public Health, University of Alberta.

Dr. Bart Hazes

From bytes to bench to bedside. (Feb. 23)

Associate Professor, Department of MMI, University of Alberta.

Dr. Stephanie Yanow

A novel mechanism of Cross-species immunity to malaria. (March 9)

Associate Professor in Global Health, School of Public Health, University of Alberta.

Dr. Daniel R. Barreda

Evolution of phagocyte contributions to the induction and resolution of acute inflammation. (March 16)

Associate Professor, Department of Agriculture, Food & Nutritional Sciences and Department of Biological Sciences, University of Alberta.

Dr. Deborah Burshtyn

Did Cytomegalovirusâ&#x20AC;&#x2122; immune evasion protein UL18 force down the human inhibitory receptor LILRB1 on NK cells. (March 23)

Professor, Department of MMI, University of Alberta; Vice Dean, Faculty of Graduate Studies & Research, University of Alberta

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