Novocastra Myosin Heavy Chain Antibodies Clone S131 1 mL lyophilized Myosin Heavy Chain (smooth muscle) NCL-MHC-Sm ASR 7 mL BOND ready-to-use PA0493 P (HIER)
IVD
Clone RNMy2/9D2 1 mL, 0.1 mL lyophilized Myosin Heavy Chain (developmental) NCL-MHCd F RUO* Clone WB-MHCf 1 mL, 0.1 mL lyophilized Myosin Heavy Chain (fast) NCL-MHCf F RUO*
Human skeletal muscle: immunohistochemical staining for myotilin using NCL-MYOTILIN. Note intense staining of muscle fibers. Paraffin section.
Clone WB-MHCn 1 mL lyophilized Myosin Heavy Chain (neonatal) NCL-MHCn F RUO*
Novocastra Napsin A Clone IP64 1 mL, 0.1 mL liquid NCL-L-NapsinA P (HIER)
Clone WB-MHCs 1 mL, 0.1 mL lyophilized Myosin Heavy Chain (slow) NCL-MHCs F RUO*
Antigen Background
Analyte Specific Reagent. Analytical and performance characteristics are not established.
Novocastra Myotilin Clone RSO34 1 mL lyophilized NCL-MYOTILIN F P (HIER)
IVD
Napsin A has a specific function in normal alveolar epithelium and is proposed to play a role in the proteolytic processing of surfactant precursors. Napsin A is reported to be predominantly expressed in lamellar bodies of type II pneumocytes, secondary lysosomes of alveolar macro-phages, respiratory epithelium of terminal and respiratory bronchioles, plasma cells, within a subset of lymphocytes in normal lung as well as in epithelial cells of renal tubules in normal kidney and is weakly expressed in normal spleen. Past studies have also reported that Napsin A is expressed in the majority of primary lung adenocarcinomas.
RUO*
Antigen Background The myotilin gene on chromosome 5q31 encodes a 498 amino acid polypeptide with a molecular weight of 57 kD. Myotilin is a structural protein of sarcomeric Z discs and sarcolemma in human skeletal and cardiac muscle. It is homologous to palladin and titin in the two C-terminal Ig-domains and also to palladin in its unique serine-rich N-terminal region. Myotilin interacts with alpha-actinin, actin and gamma-filamin. A missense mutation in the myotilin gene is associated with limb-girdle muscular dystrophy 1A (LGMD1A), an autosomal dominant disease characterized by proximal limb weakness. It is highly conserved between human and mouse with its expression being more widespread in the embryo than in the adult. Expression of myotilin has been reported in adult skeletal and cardiac muscle with variable expression reported in the peripheral nervous system, lung, liver and kidney.
IVD
In Vitro Diagnostic Use.
F Frozen
I Immunofluorescence
Human lung adenocarcinoma: immunohistochemical staining for napsin A using NCL-L-Napsin A. Note punctate cytoplasmic staining of malignant cells and infiltrating macrophages. Paraffin section.
RUO* * For Research Use Only. Not for use in diagnostic procedures.
E Electron microscopy
P Paraffin
C Flow cytometry
O Other applications
Products in this catalog are subject to regulatory approval. Please consult your Leica Biosystems representative for availability in your region.
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ASR
W Western blotting
Analyte Specific Reagent.