Glossary 53-5, 57-8, 63-6, 149, 228-9 HS-HRM (mass spectrometry) 40 immunoprecipitation 42-4 MeDNA 37 MeDIP (immunoprecipitation) 42 summary 45f challenges 34-5 influences upon summary 5 epimutation defined 8 epiphenotype 100 estrogen 191-8. 212, 244, 259-60 estrogen mimics Bisphenol A 68, 92, 153, 155f diethylstilbestrol (DES) 155f, 194, 204, 259-63, 265-6, 274 genistein 92-3, 153-4 methoxychlor 152 euchromatin defined 16 fetal or developmental programing 79, 86 gametogenesis spermatogenesis (sperm) 76-8 oogenesis (egg) 76-8 gene dosage 17 silencing, retrotransposon 18 herochromatin defined 16 heredity 78-80 genome vs. epigenome 3-4, histone 15 acetylation 17, 22, 59-60, 66, 85 acetyltransferase (HAT) 23, 60 deacetylase (HDAC) 23, 60, 66 methylation 17, 59-60 methyltransferase 24, 44, 60, 65, 67, 82, 100, 144, 193, 233 HKMT 23 LSMT 23 PRMTs 23 phosphorylation 26, 62 kinase 26 dephosphorylation 26 phosphatase 26 SUMOylation 17, 27 ubiquitination 17, 27 insulin-like growth factor2 (IGF2) 58, 99, 153, 183, 185, 187 joint venture liability 265 leptin 83-4f, 87, 90, 231-2 leukiamia 62 LINE elements 246 methyl binding proteins 21
methyl donors folate, folic acid 91 vitamin B12 91 methylation assessment ChIP (immunoprecipitation 43, 45f DNA demethylation 22. 67, 83, 92 DNA methylation 16, 20-1 DNA methyltransferase 20, 65-6, 82 hypermethylation 54-7, 85-6 hypomethylation 54, 57-9, 109 , 100, 144, 153, 193, 204 methyl binding proteins 21 miRNA, methylation of genes 61 miRNA 18, 28-9, 31-3f, 110, 149, 172 nucleosome 15f, 59 Ă–verkalix 81, 101, 106-7 study weakness 113 pesticide methoxychlor 152 vinclozoline 112, 152, 155f pharmacoepigenetics 65-6 pharmacology 67f bishenol A (BSA) 68, 92, 153, 155f cisplatin 65 Decitabine 66 diethylstilbestrol (DES) 155f, 194, 204, 259-63, 265-6, 274 folate, folic acid 91 genistein 92, 152-3 irinotecan 65 streptozotocin 90 trichostatin A (TSA) 66 valproic acid 66 vinclozolin 112 vitamin B12 91 zebularine 67 placenta 169, 172-3, 176-7, 187-8 pre-conception responsibility 117 tax 9, 272 tort law 265-6 privacy 118, 279-301 retinoblastoma 62 RNA circRNA(circular) 18, 29, 32-3f lncRNA (long non-coding) 17, 29-31, 33f mRNA (message) 28, 33f miRNA 18, 28-9, 31-3f, 110, 149, 172 methylation of miRNA genes 61 ncRNA (non-coding) 27 rRNA (ribosomal) 28 323