In collaboration with community partners at Grand Center Inc. the following research and design proposal was intended to investigate the ways that cities can support entrepreneurship in the creative economy. This was in an effort to contribute to the betterment of St. Louis’s artistic culture and urban fabric, particularly in the Grand Center Arts District neighborhood. The ideation of a co-working space for creative entrepreneurs is supported by research into national case studies, spatial and urban design strategies, and design proposal for a property currently owned by Grand Center Inc.