Page 1

o ur 4 1 ST ye ar

D EA D Z O N E D E C LI N E

IT TAKES T W O

Covering Homewood, East Baltimore, Peabody,

Just-released study shows that

Singing plain-tailed wrens

SAIS, APL and other campuses throughout the

efforts to heal the Chesapeake

show that brains come wired

Baltimore-Washington area and abroad, since 1971.

Bay are working, page 3

for cooperation, page 7

November 7, 2011

The newspaper of The Johns Hopkins University

T E C H N O L O G Y

Volume 41 No. 11

A T H L E T I C S

Blue Jay teams flying high

NSF funds massive data ‘pipeline’ By Lisa De Nike

Homewood

homewoodphoto.jhu.edu

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inanced by a $1.2 million National Science Foundation grant, one of the world’s fastest and most advanced scientific computer networks—one capable of transferring in and out of The Johns Hopkins University per day the amount of data equivalent JHU to build to 80 million file cabinets filled with blazingly text—will be built fast scientific on the university’s Homewood campus, with support computer from the University of Maryland, network College Park. The grant was announced last week by U.S. Sen. Barbara Mikulski of Maryland, who is chair of the Commerce, Justice and Science Appropriations Committee. The network will allow for the transfer and analysis of the kind of complex and massive data sets being produced today in scientific fields such as astrophysics, medical research, genomics and turbulence modeling, according to Johns Hopkins physicist and computer scientist Alexander Szalay, one of the lead researchers on the new grant. “Computer science has drastically altered the way we do science and the science that we do, and this networking capability is a crucial part of that,” said Szalay, the Alumni Centennial Professor in the Krieger School’s Henry A. Rowland Department of Physics and Astronomy and director of the university’s Institute for Data Intensive Engineering and Science. “This NSF-funded network will be one of the nation’s first public 100-gigabit-per-second Internet connections and will allow us to move data sets thousands of times bigger than we previously thought possible. Johns Hopkins will finally have world-class computing facilities.” This installation, supported by the NSF’s Office of Cyberinfrastructure, will allow Johns Hopkins to receive huge data

Midfielder Erica Suter

A record-setting season unfolds for varsity squads in multiple fall sports By Greg Rienzi

The Gazette

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ourteen minutes into a recent home game versus Gettysburg College’s women’s soccer team, senior Johns Hopkins midfielder Ava Scheininger took a quick cross from sophomore Pamela Vranis and stretched out with her right foot to deftly direct the ball on goal, some 15 yards out. The ball sailed to the bottom left-hand corner of the Gettysburg goal, hit the post and bounced in. The goal turned out to be the game-winning score and sealed an unblemished regular season for the Blue Jays. Whether an intentional shot-on-goal or not—Scheininger surely would take credit for it—the fortuitous flick and bounce illustrated how nearly everything is falling into place for Johns Hopkins’ varsity sports teams this semester. The winning appears contagious.

Melissa Cole

This past weekend, the Johns Hopkins women’s soccer, men’s soccer and volleyball teams hosted Centennial Conference tournament games as the No. 1 seed. Three JHU teams are currently nationally ranked. The women’s soccer team finished the regular season 17-0 overall, the first perfect season in the program’s history, and is ranked No. 4 in the nation. The men’s soccer team has collected four straight wins, and goes into tournament play with a 10-4-3 record. The women’s cross country team recently captured the Centennial Conference crown for the fourth straight year and next heads to the NCAA Mideast Regional Championships in Center Valley, Pa., on Nov. 12. The ladies are currently ranked No. 11 in the Women’s Cross Country National Coaches’ Poll. The Johns Hopkins football squad headed into last weekend’s home game vs. Franklin & Marshall 8-0 and ranked No. 11 in the country, the highest in-season ranking in team history. Wanting a piece of history themselves, the women of the Blue Jay volleyball team ended the regular season with a 23-4 record and a perfect 10-0 slate at home, another program first. Tom Calder, director of Athletics, said that while he’s seen his share of success in

Quarterback Hewitt Tomlin

his 24 years at Johns Hopkins, he can’t recall another fall with so many Blue Jay teams flying high. “To say it’s been exciting around here is an understatement,” Calder said. “Last year was great and pretty special, but I can’t remember a season where we went into conference tournaments with this many No. 1 seeds.” Calder mentioned a recent JHU coaches meeting where he had the pleasure of listing the accomplishments and records of all the fall varsity teams. After he was done, the coaches gave each other a round of applause. Calder said that they deserved it. “The coaches have all done an amazing job. The hardest thing is to take a one-game-at-a-time approach, which they all seem to be doing,” he said. “It’s so hard to do when you’re on a roll, like how the football and soccer teams have been, but they’ve managed to keep the players focused on their next opponent.” The Blue Jays haven’t just been winning, they’ve been routinely trouncing opponents and setting many school records along the way. The women’s soccer team has the fifth-best offense in Division III, at 4.53 Continued on page 10

Continued on page 4

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In Brief

CTY Talent Search; Best Dressed Sale; panel looks at ‘The Future of American Cities’

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10 Job Opportunities Anthony Fauci; David Axelrod; Eyes on 10 Notices Teaching workshop; blood drive at Eastern 11 Classifieds C A L E N D AR


2 2011 2 THE THE GAZETTE GAZETTE •• November August 15, 7, 2011

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‘Future of American Cities’ is subject of panel discussion

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he JHU Center for Social Concern and Tribe Inc. will present a nonpartisan panel discussion called “The Future of American Cities: Opportunities and Challenges” at 7:30 p.m. on Wednesday, Nov. 9, in the Glass Pavilion on the Homewood campus. Moderated by Anthony McCarthy of WEAA 89.9 FM, and encompassing a broad spectrum of ideological perspectives, this program will examine the future of America’s urban agenda and its place in our emerging multicultural democracy. Issues to be discussed include reduced immigration and diversity, population decline, AfricanAmerican migration to the suburbs and the impact of America’s beleaguered economy. The panelists will be Trae Lewis, Baltimore Area Young Republicans; Willie Flowers, the Park Heights Community Health Alliance; Donn Worgs, Towson University Department of Political Science; and Tom Stosur, Baltimore City Planning Department.

CTY Talent Search for gifted 2nd- to 8th-graders is under way

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he Johns Hopkins Center for Talented Youth offers academic summer programs, travel opportunities, awards and more to gifted learners in grades two through eight. Families interested in 2012 summer programs at sites around the country (nearby locations include school and college campuses in Baltimore and Montgomery County) should have their children tested as part of CTY’s Talent Search by Nov. 20 or Jan. 15 for the best choice of classes. Faculty and staff can use tuition remission according to department policies for CTY’s academic programs. For details, go to cty.jhu.edu/discover or email ctyinfo@jhu.edu.

JHU Press Night brings authors to the Ivy Book Shop Nov. 11

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eet some of the JHU Press’ local authors and get a jump on holiday gifts at the Ivy Book Shop’s JHU Press Night from 7 to 9 p.m. on Friday, Nov. 11. More than a dozen Press authors will be on hand to meet guests and sign books, including Gil Sandler (Home Front Baltimore); Cindy Kelly (Outdoor Sculpture in Baltimore); Mike Gesker (The Orioles Encyclopedia); Charley Mitchell (Maryland Voices of the Civil War); Michael Olesker (The Colts’ Baltimore); Fraser Smith (Here Lies Jim Crow); Bryan MacKay (Baltimore Trails); Ed Papenfuse (Maryland State Archives Atlas of Historic Maps of Maryland); Frank Mondimore and Patrick Kelly (Borderline Personal-

Editor Lois Perschetz Writer Greg Rienzi Production Lynna Bright Copy Editor Ann Stiller Photography Homewood Photography

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A d v e rt i s i ng The Gazelle Group Business Dianne MacLeod C i r c u l at i o n Lynette Floyd Webmaster Lauren Custer

ity Disorder); Sara and Jeff Palmer (When Your Spouse Has a Stroke); and Dinah Miller, Annette Hanson and Steve Daviss (Shrink Rap: Three Psychiatrists Explain Their Work). The event is free and open to the public, and refreshments will be served. The Ivy Book Shop is located at 6080 Falls Rd., in the Lake Falls Village shopping center. For more information, call the Ivy at 410-377-2966.

Best Dressed Sale planned for Nov. 10 to 13 at Evergreen

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esigner dresses and shoes, contemporary fashions, classic accessories and vintage clothing are among the items that will be on the racks at the Johns Hopkins Best Dressed Sale and Boutique, now in its 44th year, waiting for a place in the closets of bargain-conscious shoppers. As usual, the sale will feature both gently used and some new designer clothing, along with the vintage apparel, furs, shoes and wedding gowns. There will be a large selection of men’s suits, coats, jackets, formal wear and ties. The event takes place in the Carriage House at Evergreen Museum & Library. The pre-sale will be from 4 to 8 p.m. on Thursday, Nov. 10, with an admission fee of $45 in advance or $55 at the door. The pre-sale offers a less chaotic shopping experience and also a cocktail buffet, informal modeling and a fashion consultation. The event continues, with free admission, from 9 a.m. to 6 p.m. on Friday, Nov. 11; 10 a.m. to 4 p.m. on Saturday, Nov. 12; and 11 a.m. to 3 p.m. (when most items will be half price) on Sunday, Nov. 13. Thousands of shoppers turn out each year for this fundraiser, which is sponsored by The Women’s Board of The Johns Hopkins Hospital. All proceeds from the event, which in recent years has raised $150,000, will support patient care at the hospital. For details, go to www.womensboard .jhmi.edu/bds_buyers.cfm.

Season’s first Discovery concert at the BMA set for Saturday

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he Johannes String Quartet will open the 2011–2012 free Discovery Series of concerts, presented at the Baltimore Museum of Art by the Shriver Hall Concert Series. The quartet, whose New York appearances include Carnegie Hall and the Chamber Music Society of Lincoln Center, brings together the principal cello of the Los Angeles Philharmonic, the principal viola of the Philadelphia Orchestra, the first American in 24 years to win the Paganini Violin Competition and a Concert Artists Guild Competition winner. The musicians will play works by Salonen, Respighi and Schubert at 3 p.m. on Saturday, Nov. 12, at the BMA. No tickets are required, but a donation of $10 is suggested.

C o n t r i b u t i ng W r i t e r s Applied Physics Laboratory  Michael Buckley, Paulette Campbell Bloomberg School of Public Health Tim Parsons, Natalie Wood-Wright Carey Business School Andrew Blumberg, Patrick Ercolano Homewood Lisa De Nike, Amy Lunday, Dennis O’Shea, Tracey A. Reeves, Phil Sneiderman Johns Hopkins Medicine Christen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Ekaterina Pesheva, Vanessa Wasta, Maryalice Yakutchik Peabody Institute Richard Selden SAIS Felisa Neuringer Klubes School of Education James Campbell, Theresa Norton School of Nursing Kelly Brooks-Staub University Libraries and Museums Brian Shields, Heather Egan Stalfort

The Gazette is published weekly September through May and biweekly June through August for the Johns Hopkins University community by the Office of Communications and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date. Phone: 443-287-9900 Fax: 443-287-9920 General e-mail: gazette@jhu.edu Classifieds e-mail: gazads@jhu.edu On the Web: gazette.jhu.edu Paid advertising, which does not represent any endorsement by the university, is handled by the Gazelle Group at 410343-3362 or gazellegrp@comcast.net.


November 7, 2011 • THE GAZETTE

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E N V I R O N M E N T

Study shows efforts to heal the Chesapeake Bay are working By Phil Sneiderman

Homewood

Related websites JHU Department of Geography and Environmental Engineering:

engineering.jhu.edu/~dogee University of Maryland Center for Environmental Science:

www.umces.edu Don Boesch:

www.umces.edu/people/president Rebecca Murphy:

globalwater.jhu.edu/index.php/ bio/rebecca_r._murphy/ William Ball:

folio.jhu.edu/faculty/ William%20P._Ball

health of the Chesapeake Bay,” said lead author Rebecca R. Murphy, a doctoral student in the Department of Geography and Environmental Engineering at Johns Hopkins. “We now have evidence that cutting back on the nutrient pollutants pouring into the bay can make a difference. I think that’s really significant.” Don Boesch, president of the University of Maryland Center for Environmental Science, agreed. “This study shows that our regional efforts to limit nutrient pollution may be producing results,” he said. “Continuing nutrient reduction remains criti-

TIM MURPHY

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fforts to reduce the flow of fertilizers, animal waste and other pollutants into the Chesapeake Bay appear to be giving a boost to the bay’s health, a new study that analyzed 60 years of water-quality data has concluded. The study, published in the November issue of Estuaries and Coasts, was conducted by researchers from The Johns Hopkins University and the University of Maryland Center for Environmental Science. The team found that the size of mid- to late-summer oxygen-starved “dead zones,” where plants and water animals cannot live, leveled off in deep channels of the bay during the 1980s and has been declining ever since. The timing is key because in the 1980s a concerted effort to cut nutrient pollution in the Chesapeake Bay was initiated through the multistate-federal Chesapeake Bay Program. The goal was to restore the water quality and health of the bay. “I was really excited by these results because they point to improvement in the

Rebecca Murphy

cally important for achieving bay restoration goals.” The Chesapeake Bay is the nation’s largest estuary, a body of water where fresh and salt water mix. According to the Chesapeake Bay Program, the bay—which is about 200 miles long and has roughly 4,480 square miles of surface area—supports more than 3,600 species of plants, fish and other animals. But the bay’s health deteriorated during much of the 20th century, contributing to a drop in the Chesapeake’s fish and shellfish populations. Environmental experts blamed this decline largely on a surge of nutrients entering the bay from sources such as farm fertilizer, animal waste, water treatment discharge and atmospheric deposition. Heavy spring rains typically flush these chemicals, primarily nitrogen and phosphorus, into the Susquehanna River and other waterways that empty into the Chesapeake. There, the nutrients promote the prolific growth of algae. When the algae die, their remains sink to the bottom of the bay, where they are consumed by bacteria. As they dine on algae, the bacteria utilize dissolved oxygen in the water. This leads to a condition called hypoxia, or depletion of oxygen. As this process continues through the spring and summer, the lack of oxygen turns vast stretches of the Chesapeake into dead zones. Hypoxia sometimes results in fish kills. To find out whether these dead zones are expanding or diminishing, the Johns Hopkins and Maryland researchers retrieved and analyzed bay water quality records from the past 60 years. They determined that the size of the dead zone in mid- to late summer has decreased steadily since the late 1980s and that its duration is closely linked to the quantity of nutrients entering the bay. That timeline coincides with the launch of state and federal efforts to reduce the flow of algae-feeding pollutants into the bay. For example, farmers were encouraged to plant natural barriers and take other steps to keep fertilizer out of waterways that feed the

Chesapeake. Also, water treatment plants began to pull more pollutants from their discharge, and air pollution control measures curbed the movement of nitrogen from the atmosphere into the bay. “By looking at existing data, we have been able to link decreasing hypoxia to a reduction in the nutrient load in the bay,” said study co-author Michael Kemp, an ecologist with the University of Maryland Center for Environmental Science’s Horn Point Laboratory. “The overall extent and duration of mid- to late summer hypoxia are decreasing.” Another part of the study looked at a trend that has troubled some bay watchers. In recent years, Chesapeake researchers have seen an early summer spike in dead zones. They feared that keeping more nutrients out of the bay was not improving its health. But the new study found that the early summer jump was influenced not by the runoff of pollutants but by climate forces. In a phenomenon called stratification, fresh water from the rivers entering the bay forms a layer on top of the more dense salt water from the ocean. The two layers don’t easily mix, so while air near the surface adds

oxygen to the top layer, it doesn’t reach the deeper salt water. Without oxygen at these lower depths, marine animals cannot live, and a dead zone is formed. “Rebecca discovered that the increase in these early summer dead zones is because of changes in climate forces like wind, sea levels and the salinity of the water. It was not because the efforts to keep pollutants out of the bay were ineffective,” said co-author William P. Ball, a professor of environmental engineering in the Whiting School of Engineering at Johns Hopkins and Murphy’s doctoral adviser. “We believe,” Ball added, “that without those efforts to rein in the pollutants, the dead zone conditions in June and early July would have been even worse.” The study was supported by funding from the National Science Foundation and the U.S. Department of Commerce’s National Oceanic and Atmospheric Administration. The research was undertaken as part of a five-year Chesapeake Bay Environmental Observatory project, funded through the Chesapeake Research Consortium, which involves seven institutions. Ball serves as lead principal investigator for this project.

KSAS launches master of arts degree in public management By Brian Reil

Advanced Academic Programs

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he Johns Hopkins University has launched a master of arts degree in public management. Based at the university’s Washington DC Center, the part-time graduate program combines rigorous academics and strategic skills to meet the challenges of government and policymaking in the 21st century. The curriculum is designed for working professionals in the government and nonprofit sectors. The program is now accepting applications for its inaugural class, which will begin its studies in January 2012. The program will be offered through the Krieger School of Arts and Sciences’ Advanced Academic Programs. “At a time when governments and nonprofits at all levels are expected to do more with less, good management is essential,” said Paul Weinstein Jr., director of the Public Management Program. “The program will empower students to think strategically as they analyze and solve problems, and will also educate them in the fundamentals of sound public management.” Weinstein served as chief of staff to the White House Domestic Policy Council and

as senior adviser for policy planning to Vice President Al Gore. From 2001 to 2008, he was chief operating officer and senior fellow at the Progressive Policy Institute and chief analyst at Promontory Interfinancial Network. Most recently, he served as senior adviser to President Barack Obama’s National Commission on Fiscal Responsibility and Reform. The public management master’s degree consists of 11 graduate courses and one capstone project. Core courses include Proseminar: Essentials of Public and Private Management, Public Policy Analysis and the Policy Process, Financial Management and Analysis in the Public Sector and Economics for Public Decision Making. The new program is part of the Johns Hopkins Center for Advanced Governmental Studies. “With today’s focus in government on greater fiscal management and careful oversight, Johns Hopkins saw the need to create a public management program to enable students to develop and fine-tune the skills needed to navigate the policymaking, implementation and evaluation processes,” said Kathy Wagner, director of the center. For more about the degree program, go to publicmanagement.jhu.edu or contact Paul Weinstein at pweist3@jhu.edu or 202-663-5923.


4 2011 4 THE THE GAZETTE GAZETTE •• November August 15, 7, 2011

Virtual technology prepares JHU nurses for reality

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School of Nursing

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irtual 3-D technology is the latest innovative, state-of-the-art instruction method that will prepare Johns Hopkins nurses to be leaders of tomorrow. The technology, known as Second Life, will provide simulation scenarios allowing faculty and preceptors to practice real-life situations on virtual “patients” and “nursing students” without the anxiety of working with actual human beings. A $664,000 grant from the Nurse Support Program II over the next three years will allow the Johns Hopkins University

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Data Continued from page 1 sets from Google, Oak Ridge National Laboratory and the San Diego Supercomputing Center, among others, according to Szalay, who is the co-principal investigator on the grant with Jonathan Bagger and Mark Robbins, both professors in the Department of Physics and Astronomy at Johns Hopkins. The new system will be housed in a powerful, energy-efficient computing center in the Bloomberg Center for Physics and Astronomy on the Homewood campus, in a space that once served as the mission control center for NASA’s Far Ultraviolet Spectroscopic Explorer satellite. This transformation is being supported by a $1.3 million stimulus grant administered through the National Science Foundation. Housed in the new space will be the Homewood High-Performance Cluster, which brings

School of Nursing, in collaboration with The Johns Hopkins Hospital, to develop and test six core clinical faculty/preceptor online self-paced orientation modules expected to be completed by June 2012. These modules will examine preceptor foundations, communication, clinical reasoning, educator challenges and creation of a caring culture. Between June 2012 and June 2014, the modules will be implemented, tested, evaluated and eventually incorporated into the orientation schedules of nursing schools and hospitals across the country. Sarah “Jodi” Shaefer, an assistant professor, is lead investigator, with associate dean for academic affairs Pamela Jeffries and Leah Yoder, assistant director of the central nursing program at JHH, as co-investigators.

“Simulation has been used to train and instruct several high-risk occupations, so it stands to reason that nurses would incorporate that technology to teach our teachers,” Shaefer said. “It also affords faculty the opportunity to experience various learning situations.” Once the Second Life simulation is operational, faculty and preceptors will have avatars (virtual representations of themselves) and immerse themselves in a variety of learning situations. “Right now, hands-on virtual instruction is still a novelty to most people. We want to change that dynamic by expanding its use and making exceptional technology a standard instruction tool,” Shaefer said.

together the resources of investigators in both the Krieger School of Arts and Sciences and the Whiting School of Engineering to create a powerful and adaptive co-op facility that is designed to support large-scale computations on the Homewood campus. Also housed in the new center will be the Data-Scope, a powerful cluster of computers capable of handling colossal sets of information. The cluster will be able to handle five petabytes of information, which is the equivalent of 66.5 years of HDTV data. (To put this in context, 50 petabytes would equal the entire written work of humankind, from the beginning of history until now, in all languages.) The new apparatus will allow Johns Hopkins researchers—as well as those at other institutions, including universities and national laboratories such as Los Alamos and Oak Ridge—to conduct research directly in the database. “This new National Science Foundation grant will facilitate lightning-fast connections to the Internet, which together with

our new NSF-funded computer facility, will allow Johns Hopkins researchers to lengthen their lead in data-intensive science and engineering,” Bagger said. The network will be supported by the regional Mid-Atlantic Crossroads research and engineering network at the University of Maryland, College Park. About $950,000 of the grant money comes directly to Johns Hopkins, and the remaining $250,000 goes to the University of Maryland. G

Related websites Computing at Johns Hopkins:

gazette.jhu.edu/2010/11/01/ a-seismic-leap-for-science gazette.jhu.edu/2010/10/25/ a-space-switch-on-land idies.jhu.edu idies.jhu.edu/hpc.aspx idies.jhu.edu/research.aspx

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November 7, 2011 • THE GAZETTE

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K U D O S

JHU researcher wins prize for breast cancer biomarker studies $50,000 award recognizes potential for rapid clinical use and commercialization B y S h a nn o n S wi

ger

Johns Hopkins Medicine

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Johns Hopkins breast cancer re­­ searcher is the recipient of a $50,000 award designed to encourage rapid translation of her basic research on biomarkers into a commercially available test that could predict the best treatment options for some women with breast cancer. Sara Sukumar, co-director of the Breast Cancer Program at the Sidney Kimmel Comprehensive Cancer Center, won one of two BioMaryland LIFE Prizes at the Oct. 25 joint meeting of the Johns Hopkins

University Alliance for Science and Technology Development and the University of Maryland Baltimore Commercial Advisory Board. More than two dozen Johns Hopkins and UMB researchers presented to a group of business leaders, colleagues and venture capitalists research advances that they believe are likely to become successful products or businesses. A panel of judges selected a winner from each school to receive a $50,000 prize, funded by the Maryland Biotechnology Center and the two universities. James Gammie, a UMB researcher and associate professor of cardiac surgery, received the prize for designing a device to repair mitral valve regurgitation, a heart valve defect common in adults. His invention, he reports, offers a minimally invasive alternative to open heart surgery. Sukumar, who is also a professor of oncology and pathology at the Johns Hopkins

University School of Medicine, says that the methylated gene biomarkers her team discovered may better predict how patients whose breast cancers are estrogen receptor–negative will respond to various treatments. With further refinement, the biomarkers could show if patients are responding to therapy and if they’re at risk for future recurrences. Sukumar says she hopes that her biomarker-based test will someday help the nearly 25,000 women diagnosed with estrogen receptor–negative breast cancer each year and who unnecessarily undergo chemotherapy. “The goal is to identify patients who won’t benefit from chemotherapy so they can try out new modalities as a first-line therapy instead of going through treatment that will never help them,” Sukumar said. She will use the award funds to refine groups of markers to predict disease progression and response to therapy for women with breast cancer. Commenting on the award, which the

state supports via the Maryland Biotechnology Center, Gov. Martin O’Malley said, “In Maryland, we are fortunate to have within our borders some of the world’s best and brightest scientific minds. We are pleased to partner with our world-class universities to create jobs and support efforts to promote innovation to assert our state as a hub of research and discovery.” The Johns Hopkins Alliance for Science and Technology Development was formed eight years ago to help the university’s faculty commercialize their research and technological innovations. High-level business executives sit on the board and offer advice, networking and help in finding money to move projects forward. The meeting between the Johns Hopkins Alliance and the UMB Commercial Advisory Board is an annual opportunity for researchers to network with business leaders and present concepts that aim to translate science to business.

Cancer-causing protein tied to hormone resistance in breast cancer B y D av i d M a r c h

Johns Hopkins Medicine

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n dozens of experiments in mice and in human cancer cells, a team of Johns Hopkins scientists has closely tied production of a cancer-causing protein called TWIST to the development of estrogen resistance in women with breast cancer. Because estrogen fuels much breast cancer growth, such resistance—in which cancers go from estrogen-positive to estrogen-negative status—can sabotage anti-cancer drugs that work to block estrogen and prevent disease recurrence after surgery. Estrogen resistance develops in more than half of women taking estrogen-blocking medications, such as tamoxifen, and exists from the start in many other women. The Johns Hopkins–led team of cancer experts also reports that stalling TWIST production significantly reverses estrogen resistance. “Now that we know TWIST has a major role in controlling estrogen resistance in breast cancer, we can investigate the value of anti-TWIST therapies and how they make possible postsurgical hormone therapy for all women who have had invasive breast cancer,” said senior study investigator and breast cancer biologist Venu Raman. “We suspect that TWIST production may be an underlying cause of estrogen resistance,” added Raman, an associate professor in the Department of Radiology at the Johns Hopkins University School of Medicine and its Kimmel Cancer Center. Estrogen resistance, Raman said, not only renders tamoxifen or aromatase inhibitors,

such as anastrozole and letrozole, ineffective in women whose original estrogen receptor status was positive but also rules out these standard treatment options for the one-quarter of women who at the time of their diagnosis already are estrogen receptor–negative. The latest findings of Raman and his team, published in the journal Oncogene online Nov. 7, are the first to demonstrate a detrimental link between TWIST activity and estrogen resistance. Previous work by Raman and others had shown that TWIST was more active in women with aggressive breast cancer and less active in women whose breast tumors were benign. But researchers had not yet established the direct connection to lowered levels of estrogen receptors. In five separate cancerous cell lines grown in the laboratory, some from women with aggressive forms of breast cancer and the rest without, TWIST activity was shown in all cells to be strongly active where estrogen receptor activity was low. Further tests in human tissue samples showed the same result. In additional experiments in mice injected with breast cancer cells, researchers found that TWIST activation led to continuous and aggressive tumor growth despite tamoxifen therapy, while in mice tumors with low levels of TWIST, tumor growth waned within two months of treatment. The new experiments are also believed to be the first to show that estrogen resistance is not a permanent condition, the researchers report. Halting TWIST production in two cell lines resulted in some return of anti–estrogen drug sensitivity. Almost 40 percent of cells tested reverted from

A D M I N I S T R A T I O N

Latting of Undergrad Admissions tapped for position at Emory B y D e nn i s O ’ S h e a

University Administration

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ohn F. Latting, who has headed Undergraduate Admissions at Homewood since 2001, has been appointed assistant vice provost for undergraduate enrollment and dean of admission at Emory University. Latting will move into his new role over the next few months. At Emory, he will be responsible for recruiting freshman classes for the undergraduate schools on the university’s Atlanta campus. He also will advise university officials on enrollment issues and lead the coordination of undergraduate admissions and financial aid.

Latting began his time at Johns Hopkins as director and in 2007 became dean of Undergraduate Admissions. He is credited with more than doubling freshman applications, shaping increasingly strong entering classes and building an effective and innovative staff. “We will miss John—not only as a valued contributor to Johns Hopkins’ many successes in the past decade but also as a colleague and, for so many of us, as a friend,” said Sarah B. Steinberg, vice provost for student affairs. William T. Conley, dean of Enrollment and Academic Services, will temporarily take on the additional role of interim dean of Undergraduate Admissions.

being estrogen receptor–negative to estrogen receptor–positive, and some 30 percent of these cell receptors became tamoxifensensitive, allowing the drug to target the cancerous cells. As part of the same set of experiments, Raman and his colleagues revealed how TWIST lowers estrogen receptor activity so that it can no longer bind with the estrogen hormone or drugs designed to counteract its cancerous effects. Researchers found that increased levels of TWIST attracted and pulled in another protein, DNMT3B, which causes methylation, or addition of methyl chemical groups to a key part of the estrogen receptor, shutting down its action. TWIST also interacts with another protein, HDAC1, which causes the de-acetylation, or removal of acetyl chemical groups from a key part of the estrogen receptor, and leads to the structural compression and blocking of the estrogen receptor. Lead study investigator and breast cancer biologist Farhad Vesuna, an instructor at Johns Hopkins, said, “Our study results are particularly exciting because we went beyond establishing an association to identifying several new routes for potentially controlling and possibly reversing estrogen resistance in breast cancer.” Vesuna said that the team’s next steps are to look at various specific means of interrupting TWIST protein production, on its own or by some combination with stalling or reversing methylation and de-acetylation of estrogen receptors, done by blocking DNMT3B or HDAC1. Vesuna pointed out that TWIST is usu-

ally found at very low levels in adults but is nevertheless an essential component to human embryonic development. However, raised TWIST levels have been shown in most other cancers, including tumors of the prostate, head and neck, bladder and lung. So the team’s scientific investigations of TWIST could extend to the role it plays in all cancers, not just breast cancer. This year alone, more than 230,000 women in the United States are expected to be diagnosed with invasive breast cancer, with an estimated 39,000 deaths. More than 2.6 million American women are breast cancer survivors. Funding support for this study was provided by the National Cancer Institute. In addition to Raman and Vesuna, researchers involved in these experiments were Ala Lisok, Brian Kimble, John Domek, Yoshinori Kato, Dmitri Artemov, Joanne Kowalski and Hetty Carraway, all of Johns Hopkins; and Petra van der Groep and Paul van Diest, both of the University Medical Center Utrecht, the Netherlands.

Related websites ‘Oncogene’:

www.nature.com/onc/index.html Johns Hopkins Radiology faculty:

www.hopkinsradiology.org/ Radiology%20Faculty/ Research%20Faculty

JHU’s got talent—and passion By Greg Rienzi

The Gazette

G

ot a great idea to share, or a skill to show off? Johns Hopkins this week launches a new multimedia, community-building experience that is part open-mic night and part grown-up show and tell. Ignite@JHU is a series of five-minute talks where presenters—students, staff and faculty—will share their personal and professional passions using 20 slides that autoadvance every 15 seconds. The inaugural event will take place from 7 to 10 p.m. on Thursday, Nov. 10, in Nolan’s Cafe at Charles Commons, Homewood campus. The event is based on the successful Ignite Baltimore series held at the Walters Art Museum. Ignite@JHU will be hosted by the Digital Media Center and Charles Commons Connections.

Mike Yassa, the Charles Commons faculty fellow and an assistant professor in the Department of Psychological and Brain Sciences, said that the idea was to have an open forum where people can share ideas and passions about anything and everything. One faculty member will demonstrate his juggling and robot-building abilities, another will talk about the use of photography in studying political science. A student will discuss the present and future of video games, now a $65 billion a year industry. Hot chocolate and brownies will be served. Those planning to attend are asked to check in on the event’s Facebook page, titled Ignite@JHU. A spring Ignite@JHU will be held on March 1, 2012. Those interested in signing up can contact Joan Freedman at digitalmedia@ jhu.edu. To view samples of past Ignite Baltimore events, go to www.youtube.com/user/ igniteBaltimore.


6 2011 6 THE THE GAZETTE GAZETTE •• November August 15, 7, 2011

Yes, it’s time to talk about snow

StravinSky’S

B y D e nn i s O ’ S h e a

LiBretto By

W. H. auDen anD cHeSter kaLLman

Peabody Opera Theatre

Peabody Opera Peabody Symphony Theatre Orchestra Garnett Bruce, StaGe Director Luke HeGeL-cantareLLa, DeSiGner DouG neLSon, LiGHtinG DeSiGner

Garnett Bruce, StaGe Director Hajime teri murai, Luke HeGeL-cantareLLa, DeSiGner rutH BLauStein roSenBerG Director of orcHeStraL activitieS

Peabody Symphony Orchestra Hajime teri murai, rutH BLauStein roSenBerG Director of orcHeStraL activitieS

Patricia anD artHur moDeLL PerforminG artS center at tHe Lyric Lyric oPeraBy HouSe SPonSoreD Dr. anD mrS. aLLan D. jenSen 140 WeSt mount royaL avenue WitH aDDitionaL funDinG from marc von may

f r i D a y , n o v e m B e r 18 , 7 : 3 0 P m S u n D ay, n o v e m B e r 2 0 , 3 : 0 0 P m ticketS $35 anD$25 4 1 0 - 9 0 0 -115 0 o r v i S i t Ly r i c o P e r a H o u S e . c o m

University Administration

A

n earthquake. A hurricane. A Halloween weekend sleet storm. What’s next? The answer, inevitably, is

“snow.” And with the inevitable snow comes the inevitable question: Is Johns Hopkins open today? Again, the answer is almost inevitable: Yes. The university has a strong bias toward holding classes and operating normally when possible, even when local schools and other area colleges and universities announce delays or closures. But there are exceptions. Remember the blizzard of ’96? The blizzard of 2003? And 2010? So which will it be next time? Snowmageddon Part II, or get out the galoshes and get to class? There are two easy ways to find out for sure without even getting out of bed. Option 1: Grab the bedside phone and call the Johns Hopkins weather emergency hotline at 410-516-7781 or, from outside the Baltimore area, 800-548-9004. Option 2: Pick up your smart phone or other mobile device and check out webapps.jhu.edu/ emergencynotices. Information on the university’s status after an overnight snow is generally posted on the phone line and website by around 6 a.m., with frequent updates throughout the day during a major storm. Enter the phone numbers into your phone book and bookmark the Web address now, so that you know where to check for announcements during or after a storm. Johns Hopkins remains on a normal schedule whenever possible, both because minimizing interruptions to teaching and

research is a priority and because so many university employees and students are involved in patient care. But there are exceptions. In 2009–2010, Baltimore was hit with 77 inches of snow, more than four times the normal seasonal total. After back-to-back blizzards in February 2010, classes were canceled and most employees told to stay home for an entire week. Though Johns Hopkins notifies local news media when it closes, cancels classes or tells staff to report later than normal, there are reasons why you should rely instead on the weather emergency hotline or the emergency notices Web page: • The phone line and Web page make information on Johns Hopkins available as soon as a decision is made. Both are updated as soon as there is new information. • Both the phone line and Web page are available to you at all times. If you rely on TV or radio, you’ll have to wait until the Johns Hopkins announcement comes around. • TV and radio will not broadcast announcements when Johns Hopkins remains open, only when it is closed or has a delayed opening. The phone line and Web page will provide information whenever the weather is questionable, even if it’s just that the university is open as usual. • The phone line and Web page will provide the most complete and accurate weather emergency information available on Johns Hopkins. TV and radio stations must report on dozens or even hundreds of institutions. They do not have time to broadcast everything you need to know, including information on outpatient clinics, snow day shuttle bus operations, and library and rec center status. The university’s policy on weather-related curtailment of operations is online at hrnt .jhu.edu/pol-man/appendices/sectionJ.cfm.

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November 7, 2011 • THE GAZETTE

7

R E S E A R C H

Brains come wired for cooperation, JHU neuroscientist asserts By Lisa De Nike

Homewood

NATIONAL SCIENCE FOUNDATION

W

hen legal commentator Nancy Grace and her partner danced a lively rumba to Spandau Ballet’s 1980s hit True on Dancing With the Stars, more was going on in her brain than worry about her footwork. Deep in Grace’s cortex, millions of neurons were hard at work doing what they apparently had been built to do: act and react to partner Tristan MacManus’ movements to create a pas de deux that had the dancers functioning together (for the most part) like a well-oiled machine. That is because the brain was built for cooperative activity, whether it be dancing on a reality show, working in an office or constructing a skyscraper, according to a study led by Johns Hopkins behavioral neuroscientist Eric Fortune and published in the Nov. 4 issue of the journal Science. “What we learned is that when it comes to the brain and cooperation, the whole is definitely greater than the sum of its parts,” said Fortune, an associate professor in the Department of Psychological and Brain Sciences in the Krieger School of Arts and Sciences. “We found that the brain of each individual participant prefers the combined activity over his or her own part.” In addition to shedding light on ourselves as social and cooperative beings, the results have important implications for engineers who want to be able to program autonomous robots to work effectively as teams in settings such as combat. But Fortune’s work didn’t involve androids or take place on a battlefield. Instead, he and his team took to the cloud forests of Ecuador, on the slopes of the active Anti-

This illustration shows how plain-tailed wrens’ duet performance, conceived as a whole, emerges simultaneously in two parts.

sana volcano. Why? It’s one of the only places in the world where you can find plain-tailed wrens. These chubby-breasted rust-and-gray birds, who don’t fly so much as hop and flit through the area’s bamboo thickets, are famous for their unusual duets. Their songs—sung by one male and one female—take an ABCD form, with the male singing the A and C phrases and the female (who seems to be the song leader) singing B and D. “What’s happening is that the male and female are alternating syllables, though it often sounds like one bird singing alone, very sharply, shrilly and loudly,” said Fortune, who spent hours hacking through the thick bamboo with a machete, trying

to catch the songbirds in nets. “The wrens made an ideal subject to study cooperation because we were easily able to tape-record their singing and then make detailed measurements of the timing and sequences of syllables, and of errors and variability in singing performances.” The team then captured some of the wrens and monitored activity in the area of their brains that controls singing. They expected to find that the brain responded most to the animal’s own singing voice. But that’s not what happened. “In both males and females, we found that neurons reacted more strongly to the duet song—with both the male and female birds singing—over singing their own parts alone.

In fact, the brain’s responses to duet songs were stronger than were responses to any other sound,” he said. “It looked like the brains of wrens are wired to cooperate.” So it’s clear that Nature has equipped the brains of plain-tailed wrens in the Andes of Ecuador to work cooperatively, and to prefer “team” activities to solo ones. But what does that have to do with people? “Brains among vertebrate animals— frogs, cats, fish, bears and even humans— are more similar than most people realize,” Fortune said. “The neurotransmitter systems that control brain activity at the molecular level are nearly identical among all vertebrates, and the layout of the brain structures is the same. Thus, the kinds of phenomena that we have described in these wrens is very relevant to the brains of most, if not all, vertebrate species, including us humans.” This research was supported by the National Science Foundation. Co-authors of the study are Gregory F. Ball, of Johns Hopkins; Carlos Rodriguez, of Pontificia Universidad Catolica del Ecuador; and Melissa Coleman, of Claremont McKenna College. David Li, an undergraduate neuroscience major at Johns Hopkins, also is a co-author. To listen to the Ecuadorian plain-tailed wrens’ songs and see short videos of the birds, go to ecuador.psy.jhu.edu/nsfwren.

Related websites Eric Fortune and his lab:

neuroscience.jhu.edu/EricFortune .php pbs.jhu.edu/research/fortune/index .html

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8 2011 8 THE THE GAZETTE GAZETTE •• November August 15, 7, 2011 P R E V E N T I O N

Johns Hopkins awarded $10 mill to reduce surgical infections By Stephanie Desmon

Johns Hopkins Medicine

J

ohns Hopkins’ Armstrong Institute for Patient Safety and Quality has been awarded $10 million for a project designed to reduce surgical-site infections and other major complications of colon surgery. The money comes from the Agency for Healthcare Research and Quality, part of the Department of Health and Human Services, and the project is in partnership with the American College of Surgeons. Armstrong Institute Director Peter J. Pronovost says that the work will be modeled on the success his team has had in developing a cockpit-style five-step checklist coupled with a program of departmen-

tal culture change that has dramatically reduced central line–associated bloodstream infections in intensive care units throughout the state of Michigan. Pronovost’s Comprehensive Unit-based Safety Program, known as CUSP—which is now in place in nearly every state, the District of Columbia, Puerto Rico and many nations around the world— is believed to have saved thousands of lives and millions of health care dollars. “This work will build on our knowledge of how to prevent central line infections and apply it to the task of preventing surgical-site infections, pneumonia, deepvein thrombosis and other common surgical complications,” he said. “We should be able to repeat that success in other areas.” The use of the American College of Surgeons’ vast database will be an invaluable N O V .

part of the new research, Pronovost says. The surgical safety program will begin in 10 states, in at least 10 hospitals in each. The hope is to ultimately create programs in all 50 states that can be used to reduce surgicalsite infections and complications and eventually to reduce infections in other kinds of surgeries. Johns Hopkins will partner with the World Health Organization to broadly disseminate what is learned. The project will utilize a new concept known as “clinical communities,” a system of developing patient safety and quality improvement programs from the ground up instead of having new directives sent down from executives. The Agency for Healthcare Research and Quality has also awarded the Armstrong Institute more than $700,000 for an 18-month 7

1 4

Calendar Continued from page 12 “Heme Trafficking From the Ground Up,” a Biochemistry and Molecular Biology seminar with Iqbal Hamza, University of Maryland. W1020 SPH. EB

Mon., Nov. 7, noon.

“Noncoding RNAs: With a Viral Twist,” a Carnegie Institution Embryology seminar with Joan Steitz, Yale University. Rose Auditorium, 3520 San Martin Drive. HW Mon., Nov. 7, 12:15 p.m.

Mon., Nov. 7, 1:30 p.m. “Neural Adaptations to a Brain-Machine Interface,” a Biomedical Engineering seminar with Jose Carmena, University of California, Berkeley. 709 Traylor. EB (Videoconferenced to 110 Clark. HW )

“Resolvent Estimates in Trapping Geometries,” an Analysis seminar with Jared Wunsch, Northwestern University. Sponsored by Mathematics. 300 Krieger. HW

Mon., Nov. 7, 4 p.m.

Mon.,

Nov.

7,

4:30

p.m.

“Thom-Sebastiani and Duality for Matrix Factorizations (via DAG),” a Topology seminar with Anatoly Preygel, MIT. Sponsored by Mathematics. 308 Krieger. HW “Current NIOSH Research in Mining and Safety,” a Graduate Seminar in Injury Research and Policy with Joel Haight of the National Institute for Occupational Safety and Health, the Centers for Disease Control and Prevention, and the U.S. Department of Health and Human Services. Co-sponsored by Health Policy and Management, the Center for Injury Research and Policy, and the Education and Research Center for Occupational Safety and Health. W2017 SPH. EB

Tues., Nov. 8, 12:10 p.m.

“An Evaluation of the Food Environment Along Paths to School, Its Impact on Childhood Obesity and Zoning as a Policy Solution,” a Health Policy and Management thesis defense seminar with Lauren Rossen. W2017 SPH. EB

Tues., Nov. 8, 2 p.m.

Tues., Nov. 8, 3 p.m. The M. Gordon Wolman Seminar— “Technion Grand Water Research Institute: A Pilot Solving Water Problems for the World” with Noah Galil, Technion, Israel. Sponsored by Geography and Environmental Engineering. 234 Ames. HW

“Vanishing Theorems,” an Algebraic Geometry/Number Theory seminar with Victor Lozovanu, Queen’s University at Kingston. Sponsored by Mathematics. 302 Krieger. HW Tues., Nov. 8, 4:30 p.m.

Mental Health Noon Seminar—“The Culture of Primary Care: Developing Patient-Centered Interventions” with Marsha Wittink, University of Rochester School of Medicine and Dentistry. B14B Hampton House. EB

Wed., Nov. 9, 12:15 p.m.

“Statistical Analysis of Multisite Time Series Data for Estimating Health Effects of Environmental Exposures,” a Biostatistics thesis defense seminar with Jennifer Feder Bobb. E6519 SPH. EB Wed., Nov. 9, 1 p.m.

“The Transcription Factor Nrf2 as a Target to Reduce Neurodegeneration and Neuroinflammation in Parkinson’s Disease,” a Pharmacology and Molecular Sciences seminar with Antonio Cuadrado, Autonomous University of Madrid Medical College. West Lecture Hall (ground floor), WBSB. EB

Wed., Nov. 9, 4 p.m.

Biomolecular Architectures and Systems for Nanoscience Engineering,” a Chemical and Biomolecular Engineering seminar with Jennifer Cha, University of California, San Diego. 110 Maryland. HW

Thurs., Nov. 10, 10:45 a.m.

The Bromery Seminar—“An Emerging Picture of Late Proterozoic Ocean Chemistry” with David Johnston, Harvard University. Sponsored by Earth and Planetary Sciences. Olin Auditorium. HW

Thurs., Nov. 10, noon.

“TransMetabolic

Thurs., Nov. 10, noon.

lating

Microbial

Exchange,” a Molecular Microbiology and Immunology/Infectious Diseases seminar with Pieter Dorrestein, University of California, San Diego. W1020 SPH. EB “Toward a Cell Biology of Pain,” a Neuroscience research seminar with Jon Levine, University of California, San Francisco. West Lecture Hall (ground floor), WBSB. EB

Thurs., Nov. 10, 1 p.m.

Thurs.,

Nov.

10,

1:30

p.m.

“Detecting Change in Multivariate Data Streams Using Minimum Subgraphs,” an Applied Mathematics and Statistics seminar with Robert Koyak, Naval Postgraduate School. 304 Whitehead. HW Thurs., Nov. 10, 3 to 6 p.m., and Fri., Nov. 11, 9 a.m. to 12:30 p.m. The Futures Semi-

nar—German and Romance Languages and Literatures, with Ruben Gallo, Princeton University; Joshua Landy, Stanford University; Helmut Muller-Sievers, University of Colorado; and Arielle Saiber, Bowdoin College. Mason Hall Auditorium (Thursday) and Charles Commons (Friday). HW Thurs., Nov. 10, 4 p.m. “Surving the Deal: A Journalistic Odyssey,” a Press and Public Policy seminar with James O’Shea, editor/founder, Chicago News Cooperative, and author of The Deal From Hell: How Moguls and Wall Street Plundered Great American Newspapers. Sponsored by the Institute for Policy Studies. 50 Gilman. HW

Fri., Nov. 11, 10 a.m. “Characterizing the Effects of Cell-Type Specific Human IL-10 Expression on Disease Susceptibility,” a Molecular Microbiology and Immunology thesis defense seminar with Dilini Ranatunga. W1214 SPH. EB

Special Bodian Seminar—“Neuronal Mechanisms for Perceptual Grouping” with Pieter Roelfsema, Neuroscience Institute of the Netherlands. Sponsored by the Krieger Mind/Brain Institute. 338 Krieger. HW

Fri., Nov. 11, 2 p.m.

program to develop and implement CUSP in two states to prevent ventilator-associated pneumonia. Once the pilot program shows positive results, the hope is that it, too, could be implemented nationwide. This contract is one of several important new contracts or grants received by the Armstrong Institute, which was established in May with a $10 million gift from C. Michael Armstrong, the chairman of the board of trustees of Johns Hopkins Medicine and retired chairman of Comcast, AT&T, Hughes Electronics and IBM World Trade Corp. The goal of the institute is to advance the science of reducing preventable harm and to improve health care quality, in order to benefit patients not only at Johns Hopkins but around the world. For more on the Armstrong Institute, go to www.hopkinsmedicine.org/armstrong_institute.

The David Bodian Seminar—“Reciprocal Mechanisms of Alpha and Gamma Oscillations in Monkey Primary Visual Cortex” with Timo van Kerkoerle, Neuroscience Institute of the Netherlands. Sponsored by the Krieger Mind/Brain Institute. 338 Krieger. HW

Fri., Nov. 11, 9 a.m. to 6 p.m.

“Learning Semantic Parsers for More Languages and With Less Supervision,” a Center for Language and Speech Processing seminar with Luke Zettlemoyer, University of Washington. B17 Hackerman.

Sat., Nov. 12, 10 a.m. to 4 p.m.

Sun., Nov. 13, 11 a.m. to 3 p.m.

Fri., Nov. 11, 4 p.m.

er, pre-sale shopping, informal modeling, fashion consultation and light refreshments. $45 in advance, $55 at the door.

Fri., Nov. 11, 4:30 p.m.

HW Mon., Nov. 14, 12:15 p.m. “Synthetic Cell Biology: Visualizing and Manipulating Cell Signaling,” a Carnegie Institution Embryology seminar with Takanari Inoue, SoM. Rose Auditorium, 3520 San Martin Drive. HW Mon., Nov. 14, 4 p.m. “Holomorphic Extensions and the Complex Monge-Ampere Equation,” an Analysis/PDE seminar with Dan Burns, University of Michigan. Sponsored by Mathematics. 300 Krieger. HW

SPECIAL EVENTS

Mon., Nov. 7, 4 p.m. Hopkins Medicine Distinguished Speaker Series—“Viral Reaction: Emergent Disease in an Increasingly Connected Society—Implications for Science, Medicine and Policy” with Anthony Fauci, director, NIAID, and a faculty panel. (See story, p. 9.) West Lecture Hall, Armstrong Medical Education Bldg. EB Tues., Nov. 8, 8 p.m. The 2011 Milton S. Eisenhower Symposium—America’s Boundless Possibilities: Innovate, Advance, Transform, with David Axelrod, adviser to President Barack Obama. Talks are followed by a question-andanswer session and reception. Shriver Hall Auditorium. HW Johns Hopkins Best Dressed Sale and Boutique , sponsored

by the Women’s Board of The Johns Hopkins Hospital to support patient care. Admission to the sale is free, but there is a charge for the preview party fundraiser (see below). For more information, go to www.womensboard .jhmi.edu/bds_buyers.cfm, call 410955-9341 or email jhhwb@jhmi .edu. Evergreen Carriage House.

Thurs., Nov. 10, 4 to 8 p.m. Preview party fundrais-

Thurs., Nov. 10, 7 to 10 p.m.

Ignite@JHU, a multimedia community-building experience for faculty, staff and students. Sponsored by the Digital Media Center and Charles Commons Connections. (See story, p. 5.) Nolan’s Cafe, Charles Commons. HW Fri., Nov. 11, 1:30 to 5 p.m.

“Baltimore Painted Furniture,” an InSIGHT symposium with Gregory Weidman, curator, Hampton National Historic Site; painting conservator Deborah Duerbeck Parr; and contemporary furniture craftsman David Wiesand. The event opens with remarks by William Voss Elder II, curator emeritus, BMA. There will be a concluding reception at 5 p.m. Sponsored by University Museums. $30 general admission, $25 for museum members, $15 for full-time students with ID. Advance registration is required; register online at www. museums.jhu.edu or by calling 410516-5589. Enrollment is limited to 40 participants. Homewood Museum. HW

W OR K S H O P S

Tues.,

Nov.

8,

1:30

p.m.

“Instructional Media and Technology,” an Eyes on Teaching workshop open to all grad students, postdoctoral fellows, lecturers and faculty in KSAS or WSE. To register, go to www.cer.jhu.edu/ events.html. Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW Wed., Nov. 9, 1 p.m. “Universal Design—How Accommodating Disabilities Improves Learning for All,” a Bits & Bytes workshop. The training is open to full-time Homewood faculty, lecturers and TAs; staff are also welcome to attend. To register, go to www.cer.jhu.edu/ events.html. Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW


November 7, 2011 • THE GAZETTE

9

Outbreaks: Experts discuss roles of social media, medical response teams B y D av i d M a r c h

Johns Hopkins Medicine

A

nthony S. Fauci, the renowned longtime director of the National Institute of Allergy and Infectious Diseases and winner of the Presidential Medal of Freedom for his groundbreaking work in battling the HIV/AIDS pandemic and establishing national biodefense programs, will lead a panel of disaster preparedness experts today, Nov. 7, as part of this fall’s Johns Hopkins Medicine Distinguished Speaker Series. The topic of the free public event, to be

held from 4 to 6 p.m. in the Anne and Mike Armstrong Medical Education Building on Johns Hopkins’ East Baltimore medical campus, is “Viral Reaction: Emergent Disease in an Increasingly Connected Society,” and panelists will discuss the implications for science, medicine and policy. Fauci, an internationally recognized authority on global infectious diseases and an immunologist, will be joined by speakers from the Johns Hopkins University schools of Medicine and Public Health to discuss how planning for, and responding to, disease outbreaks has changed in today’s wired and technologically mobile society. Johns Hopkins chose the topic in part

because of the popularity of the recently released film Contagion, a fictitious account of a global disease outbreak. The presentations will be grounded in real-life crises stemming from the outbreaks of influenza A (H1N1) in 2009, multidrug-resistant TB in 2007 and severe acute respiratory syndrome (SARS) in 2002 and 2003. The panel discussion, followed by a question-and-answer session for the audience, will be chaired by Atul Nakhasi, a Johns Hopkins first-year medical student and head of the speaker series, and will conclude with a public reception. Fauci, who was a 2007 recipient of the Lasker Award for Public Service, will be

joined on the panel by Johns Hopkins faculty members Katherine Clegg Smith, a sociologist with expertise in how people respond to news and social media during an outbreak; Jonathan Links, a medical physicist and Baltimore City’s pandemic and influenza planning adviser; Joshua Epstein, an expert in social and behavioral computer modeling of disease outbreaks and their spread; Khalil Ghanem, an internist and infectious disease specialist; and event moderator Tom Quinn, an infectious disease specialist and expert in the spread of sexually transmitted diseases, especially HIV/AIDS, and director of Johns Hopkins’ Center for Global Health.

Johns Hopkins scientists discover ‘fickle’ DNA change in brain

SAIS hosts launch of Eliot Cohen book on the American way of war

Finding has implications for treatment of wide range of diseases

B y F e l i s a N e u r i ng e r K l u b e s

By Maryalice Yakutchik

Johns Hopkins Medicine

J

ohns Hopkins scientists investigating chemical modifications across the genomes of adult mice have discovered that DNA modifications in nondividing brain cells, thought to be inherently stable, underwent large-scale dynamic changes as a result of stimulated brain activity. Their report, in the October issue of Nature Neuroscience, has major implications for treating psychiatric diseases and neurodegenerative disorders, and for better understanding learning, memory and mood regulation. Specifically, the researchers found evidence of an epigenetic change called demethylation—the loss of a methyl group from specific locations—in the nondividing brain cells’ DNA, challenging the scientific dogma that even if the DNA in nondividing adult neurons changes on occasion from a methylated to a demethylated state, it does so very infrequently. “We provide definitive evidence suggesting that DNA demethylation happens in nondividing neurons, and it happens on a large scale,” said Hongjun Song, a professor of neurology and neuroscience and director of the Stem Cell Program in the Institute for Cell Engineering at the Johns Hopkins University School of Medicine. “Scientists have previously underestimated how important this epigenetic mechanism can be in the adult brain, and the scope of change is dramatic.” DNA comprises the fixed chemical building blocks of each person or animal’s genome, but the addition or removal of a methyl group at the specific location chemically alters DNA and regulates gene expression, enabling cells with the same genetic code to acquire and activate separate functions. In previously published work, the same Johns Hopkins researchers reported that electrical brain stimulation, such as that used in electroconvulsive therapy for patients with drug-resistant depression, resulted in increased brain cell growth in mice, due likely to changes in DNA methylation status. This time, they again used electric shock to stimulate the brains of live mice. A few hours after administering the stimulation, the scientists analyzed 2 million of the same type of neurons from the mouse brains, focusing on what happens to one building block of DNA—cytosine—at 219,991 sites. These sites represented about 1 percent of all cytosines in the whole mouse genomes. In collaboration with genomic biologist Yuan Gao, now at the Lieber Institute for Brain Development, the scientists used the latest DNA sequencing technology and compared neurons in mice with or without

brain stimulation. About 1.4 percent of the cytosines measured showed rapid active demethylation or became newly methylated. “It was mind-boggling to see that so many methylation sites—thousands of sites—had changed in status as a result of brain activity,” Song said. “We used to think that the brain’s epigenetic DNA methylation landscape was as stable as mountains and more recently realized that maybe it was a bit more subject to change, perhaps like trees occasionally bent in a storm. But now we show it is most of all like a river that reacts to storms of activity by moving and changing fast.” The majority of the sites where the methylation status of the cytosine changed as a result of the brain activity were not in the expected areas of the genome that are traditionally believed to control gene expression, Song notes. Rather, they were in regions where cytosines are low in density, in genomic regions where the function of DNA methylation is not well-understood. Because DNA demethylation can occur passively during cell division, the scientists targeted radiation to the sections of mouse brains they were studying, permanently pre-

Related websites Hongjun Song:

neuroscience.jhu.edu/ HongjunSong.php Guo-li Ming:

neuroscience.jhu.edu/GuoliMing .php venting passive cell division, and still found evidence of DNA demethylation. This confirms, they say, that the DNA methylation changes they measured occurred independently of cell division. “Our finding opens up new opportunities to figure out if these epigenetic modifications are potential drug targets for treating depression, and promote regeneration, for instance,” said Guo-li Ming, a professor of neurology and neuroscience at the Johns Hopkins School of Medicine. This research was supported by the National Institutes of Health, a McKnight Scholar Award, the Brain and Behavior Research Foundation, the Adelson Medical Research Foundation and the Johns Hopkins Brain Science Institute. Authors of the paper from Johns Hopkins, in addition to Song and Ming, are Junjie U. Guo, Dengke K. Ma, Eric Ford, Mi-Hyeon Jang, Michael A Bonaguidi and Yuan Gao. The cover art of the October issue of Nature Neuroscience that illustrates this research paper is a Chinese landscape painted by Max Song, who is the 13-year-old son of Song and Ming. Other authors are Huan Mo and Hugh L. Eaves, both of the Virginia Commonwealth University; Madeleine P. Ball, of Harvard Medical School; Jacob A Balazer, of Proofpoint Inc.; Bin Xie, of Lieber Institute for Brain Development; and Kun Zhang, of the University of California, San Diego.

SAIS

T

he Nitze School of Advanced International Studies will host a discussion of Conquered Into Liberty: Two Centuries of Battles Along the Great Warpath That Made the American Way of War, a new book by Eliot Cohen, director of the SAIS Strategic Studies Program, at 6 p.m. on Thursday, Nov. 10. Cohen’s introductory remarks will be followed by a panel discussion by Tom Ricks, author and military journalist; Nicholas Westbrook, director emeritus of Fort Ticonderoga; and Charles Doran (moderator), director of the SAIS Canadian Studies and International Relations programs. In Conquered Into Liberty, to be released Nov. 15 by Free Press, Cohen describes how the British, French, Americans, Canadians and Indians fought over the key to the

North American continent: the corridor running from Albany, N.Y., to Montreal that was dominated by the Champlain Valley and known to Native Americans as the “Great Warpath.” He reveals how conflict along these 200 miles of lake, river and woodland shaped the country’s military values, practices and institutions. Even today, the Great Warpath legacy endures, says Cohen, who is the author of the prize-winning Supreme Command and former counselor of the U.S. Department of State. U.S. Army rangers trace their lineage and military culture to the ranger unit formed here in the middle of the 18th century by Robert Rogers, he says, and when Navy SEALs killed Osama bin Laden in Pakistan this year, they took part in the tradition of “cross-border operations” stretching back centuries. The event will be held in the Nitze Building’s Kenney Auditorium. Non-SAIS affiliates should RSVP to conquered.into .liberty2011@gmail.com.

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10 2011 10 THE THE GAZETTE GAZETTE •• November August 15, 7, 2011 H U M A N

R E S O U R C E S

B U L L E T I N

B O A R D

Notices No notices were submitted for publication this week.

Hot Jobs Listed below are some of the university’s newest openings for indemand jobs that we most urgently need to fill. In addition to considering these opportunities, candidates are invited to search a complete listing of openings and apply for positions online at jobs.jhu.edu.

Community Public Health chair named at School of Nursing B y J o n at h a n E i c h b e r g e r

School of Nursing

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Homewood Office of Human Resources Wyman Park Building, Suite W600 410-516-7196 Critical postings within our Homewood Division include the following three positions; applications are being accepted for these immediate opportunities. For detailed job descriptions and to apply, go to jobs.jhu.edu. 50367 50431 50246

Annual Giving Data Specialist Human Resources Services Representative Administrative Coordinator

School of Medicine Office of Human Resources 98 N. Broadway, Suite 300 410-955-2990 Are you a mid-level care provider looking for a great employment opportunity? The Division of Pulmonary and Critical Care, which is committed to superb patient care and cutting edge research, has several vacancies for applicants who strive to provide compassionate, state-of-the-art patient care of the highest quality. For detailed job descriptions and to apply, go to jobs.jhu.edu. 48971 48972 48973

Nurse Practitioner/Physician Assistant Nurse Practitioner/Physician Assistant Nurse Practitioner/Physician Assistant

Schools of Public Health and Nursing Office of Human Resources 2021 E. Monument St. 410-955-3006 The Bloomberg School of Public Health has on-call opportunities within the Weight Management Center. For detailed job descriptions and to apply, go to jobs.jhu.edu. 50323 Exercise Counselor 50322 Dietitian

Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria.

Woodcliffe Manor Apartments

S PA C I O U S

G A R D E N A PA RT M E N T L I V I N G I N

R O L A N D PA R K

• Large airy rooms • Hardwood Floors • Private balcony or terrace • Beautiful garden setting • Private parking available • University Parkway at West 39th St. 2 & 3 bedroom apartments located in a private park setting. Adjacent to Johns Hopkins University Homewood Campus and minutes from downtown Baltimore.

410-243-1216

105 West 39th St. • Baltimore, MD 21210 Managed by The Broadview at Roland Park BroadviewApartments.com

he Johns Hopkins University School of Nursing has selected Christine Savage as chair of the Department of Community Public Health, beginning Jan. 1. “The faculty found her to be passionate and enthusiastic about public health nursing with an exciting and clear vision for the department and for advancing the school’s role in community nursing,” said Martha N. Hill, dean of the school. “I wholeheartedly agree with them.” Savage is currently a professor in the University of Cincinnati’s College of Nursing and College of Medicine’s Department of Public Health Science. She also serves as the associate director of the University Hospital Institute of Nursing Research. Prior to joining the faculty of the Univer-

Blue Jays Continued from page 1 goals per game. It’s won two games by scores of 6-0, and two by 8-0 margins. Leading the way is senior Erica Suter, who this year became the team’s all-time leader in points, goals and assists. Head coach Leo Weil, now in his 20th season, said that despite losing such standouts as Jenn Paulucci and Allie Zazzali to graduation, he saw the potential for a more well-rounded, improved team. Weil recruited a talented freshman class, led by Hannah Kronick, who has scored 18 goals this season, two short of the freshman record. The goals have come fast and furious from multiple sources, with three players (Suter, Vranis and senior Paulina Goodman) recording hat tricks. “We have plenty of offense, lots of people who can score,” Weil said. “One of our goals going into the season was to put a lot of pressure on every team’s defense. I wanted to make it hard to prepare for us. If teams pack it in, we can be patient and wait for our chances; if they want to push up to draw us offside, we can take advantage of that, too.” Weil said that in a season full of bright moments, a particular highlight was a 5-1 victory over previously undefeated Haverford College. “We wanted to send a message that game that it was going to be tough for anyone to beat us,” he said. Message sent. With confidence sky high, Weil said that the trick is keeping everyone focused and grounded. “It’s easy to get overconfident,” he said. “You have to be careful. You can’t presume we are going to be successful just taking the field.” Jim Margraff, JHU’s football head coach, is taking a similar approach with his squad. He recently borrowed a phrase from New England Patriots head coach Bill Belichick and told his team to “ignore the noise,” referring to the attention and praise the team has received. “I tell them that the goal is simply be 1-0 every week,” said Margraff, now in his 22nd season as head coach. “Focus on the here and now.” His philosophy appears to be working. The Blue Jays have won a school-record 13 straight games dating back to last season,

sity of Cincinnati in 1997, Savage was a guest lecturer at the University of Maryland, Baltimore, School of Nursing and at the York College (Pa.) Department of Nursing. “I look forward to joining a school of nursing that is committed to innovation and excellence in nursing education, science and practice,” Savage said. “I’m excited to work with a motivated and talented team of nurse educators in the Department of Community Public Health.” Savage has worked with vulnerable populations for most of her career, beginning as a maternal/child health nurse in the 1970s and 1980s. Based on these experiences, she became interested in the role that alcohol and drugs play in increasing vulnerability in certain populations. She later became involved in the field of addictions nursing and served as president of the International Nurses Society on Addictions from 2003 to 2006.

the third-longest active winning streak in all divisions of NCAA football. The team clinched a share of the Centennial Conference title and a spot in the upcoming NCAA playoffs with its win last week over Ursinus. The team averages 46.5 points per game, led by the third-ranked passing attack in the nation. Equally impressive, it gives up only just over 9 points a game. The team routed Moravian 41-0, and four weeks later put up a basketball score vs. Gettysburg, winning 83-21. In the Gettysburg game, senior quarterback Hewitt Tomlin threw for 501 yards and seven touchdowns, both school records. Tomlin further etched his name in the Centennial Conference record book in the victory, becoming the league’s career leader in total offense and 300-yard passing games. Tomlin has thrown for 1,756 yards this year to date, with 19 touchdowns against only two interceptions. He’s averaging 291 yards a game. The team even survived the loss of Tomlin, due to injury, for several games and never skipped a beat. Margraff said that going into the season, he thought this could be a very special team. “To be honest, our expectations were quite high,” he said. “We had a large number of seniors returning, and some very talented freshmen. And when your best players are your hardest workers, that gives you a good foundation, and sets you up for success.” The Johns Hopkins volleyball team currently has a 17-match home winning streak and a 13-match overall undefeated streak, both team records. This season marked the first time in program history that the volleyball team went undefeated in conference play. It ended the regular season with a 23-4 overall record, collecting 18 shutouts along the way. Senior Melissa Cole is solidifying her place in the Johns Hopkins record books with her outstanding final season in a Blue Jay uniform. Cole is currently second on the team in digs (256) and kills (219) and is nearing the top 10 in both categories for her overall career. With conference tournament action under way and NCAA tournaments just around the corner, Calder said he’s hoping that fans will turn out to see some recordsetting teams in action. G To see this past weekend’s results and for upcoming schedules, go to www.hopkinssports .com.


November 7, 2011 • THE GAZETTE

Classifieds APARTMENTS/HOUSES FOR RENT

Bolton Hill, studio/1BR apt, huge windows, fp, full kitchen, deck, yd, priv prkng, huge BA w/double vanities, sep shower, soaking tub, can be partly furn’d, great for short-term residents. $950/mo. erasmocha@ yahoo.com. Deep Creek Lake/Wisp, cozy 2BR cabin w/ full kitchen, call for wkly/wknd rentals. 410638-9417 or jzpics@yahoo.com (for pics). Ellicott City, spacious 3BR, 2.5BA TH, kitchen/dining area, new windows, fin’d walkout bsmt, deck/patio, in Centennial high school zone. $1,875/mo. 410-979-9065 or rashmachaudhry@yahoo.com. Federal Hill, 2BR, 1BA rehab, 3 stories, water view, backyd, prkng, avail Dec 1. $1,900/mo (negotiable). 902-254-2040. Fells Point, 3BR, 1BA house, 3 stories, office, laundry, shed, storage, walking distance to JHH/shuttle/Carey Business School. $1,100/mo + utils. 410-283-1730 or zaremaz2003@yahoo.com. Mt Vernon, lg bsmt apt, could accommodate 3 people, nr JHMI shuttle. $1,350/mo incl all utils. 425-890-1327 or qinyingtan@ gmail.com. Mt Washington, 3BR, 2.5BA condo, dw, W/D, CAC, lg balcony, garage prkng, lg swimming pool and tennis court, nr I-83/ light rail. $1,400/mo + utils. 443-220-2138 or hLhuang@gmail.com. Nottingham/White Marsh, 2BR, 2BA TH w/vaulted ceilings, fp, W/D. $1,200/mo. 240-522-9075 or matenerichards@mris.com. Parkside Drive, 1BR apt, 2nd flr, across from park, 10- to 15-min drive to JHH/JHU, pref nonsmoker, must pass rental application. $575/mo incl heat. Paula, 410-868-2815 or paulakowale@gmail.com. Perry Hall, 1BR apt w/new appls, fresh paint, crpt, laundry rm, on dead-end street (no facing houses for privacy), great for senior living or mature tenant, easy access to 95/695. $1,000/mo. 443-882-5266 or christineepps0@msn.com. Roland Park, lg 1BR apt + dining rm, avail Dec 1. $1,100/mo incl heat, garage space, storage unit. mikesuse@comcast.net. Towson, 3BR rancher w/double BA, central gas heat and AC, fin’d bsmt, fenced yd, openair garage. 410-821-0058 or hlfreycorp@ yahoo.com.

M A R K E T P L A C E

3BR, 3.5BA house, 6 blks south of JHH, 2-car garage. 267-738-2161 or jodyseshadri@ yahoo.com. Sublet 1BR apt, Nov 19–30, quiet neighborhood, 15-min walk to Penn Station. $25/ day all-inclusive. 573-529-4358 (eve) or qhgb253@gmail.com. 2907 St Paul St, newly renov’d 1BR apt, 1st flr, hdwd flrs, new cabinets, safe and quiet neighborhood. $900/mo incl heat, water. murilo_silvia@hotmail.com.

HOUSES FOR SALE

Catonsville, fully renov’d 3BR, 2BA RH, hdwd flrs throughout, new windows, movein ready, affordable. $149,900. 443-8516514 or panfile@gmail.com. Ellicott City, 4BR, 2BA+ colonial, quiet culde-sac location, great school district, perfect for young family. $550,000. 410-531-0321 or www.homesandland.com/Real_Estate/MD/ City/Ellicott_City/listingid/17510859.html. Fells Point (300 blk S Durham St), 3 stories, just renov’d, big yd, 3 blks to JHH. $175,000. Dorothy, 410-419-3902. Guilford, gorgeous, renov’d 3BR, 3BA architect-designed condo, 2,200 sq ft (incl huge terrace), gourmet kitchen, living rm, dining rm, family rm, 2 prkng spaces, at JHU shuttle stop, 5-min walk to Homewood campus. 410-366-8507 or jz1234@earthlink.net. Owings Mills New Town, 2BR condo, nr metro, ready for immediate sale. www.4409silverbrook.info. Rosedale, 4BR house in quiet neighborhood, 2 full BAs, all appls, off-street prkng, movein cond at an affordable price. $199,900. Don, 410-499-2139. Timonium/Lutherville, 4BR, 2.5BA house, 5 fin’d levels, fp, hdwd flrs, nr I-83, easy access to all Hopkins campuses. $420,000. Val, 443-994-8938. 3BR, 2.5BA TH, approx 11 mi to JHH, 6.5 mi to BWI. ktbsn@mac.com.

ROOMMATES WANTED

Nonsmoker wanted for furn’d 700 sq ft BR in 3BR house in Cedonia owned by young F prof’l, bright, spacious, modern kitchen w/ convection oven, walk-in closet, landscaped yd, lg deck, free prkng, public transportation to JHU, wireless Internet incl’d. $550/mo + utils. 410-493-2435 or aprede1@yahoo.com. Share all new refurbished TH w/medical students, 4BRs, 2 full BAs, CAC, W/D, dw, w/w crpt, 1-min walk to JHMI, 924 N Broadway. gretrieval@aol.com. Nonsmoker wanted for rm in new TH, walking distance to JHMI, no pets. 301-7174217 or jiez@jayzhang.com.

In the restaurant or in the boardroom let Chef Langermann handle the details. boston street | baltimore 410.534.3287 | langermanns.com

Walk to JHU from this sophisticated, spacious condo with renovated kit., enlarged MB, lg.-cap. W/D, underground pkg., 24/7 sec., fitness/sauna, outdoor pool & guest rooms! $165,000

Quiet prof’l wanted for BR in TH 10 mins from Homewood, walk to MTA #11 bus, must be quiet, very clean, nonsmoker, love dogs, credit and background check req’d. $500/month-to-month incl cable, WiFi, heat/H20. jennyedd@gmail.com. F prof’l wanted for lg, unfurn’d BR in 3BR home nr Ft Meade, on golf course, gym area w/treadmill and weight system, community swimming pool, tennis court, walking/run-

ning trails. $700/mo + 1/3 elec and 1/3 cable + $400 sec dep (terms negotiable). Timisha, 301-887-3066 or timishalp@hotmail.com.

housekeeping, free time during the day, free rm and board w/pay. 301-412-5588 or helenliucfa@gmail.com.

M nonsmoker wanted for 2BR, 3BA TH, 2 blks to the JHMI campus, prkng provided, no pets. $700/mo. maimon.hubbi@gmail.com.

Mature but relaxed prof’l looking for a rm, sublet, apt or share in the Charles Village vicinity. 347-403-2066 or josephmauricio@ yahoo.com.

F grad or staff wanted for furn’d 3BR, 2BA house, short-term OK, avail mid-Dec. $550/ mo incl utils + sec dep. skbzok@verizon.net.

Thanksgiving pet food drive, donate a bag of dog/cat food. 410-870-2037 or www .thankfulpaws.org.

F prof’l/grad student wanted to share 3BR, 1.5BA TH in Middle River, fp, walk-in closet, off bus line and train station. $600/mo incl utils, cable, Internet. marquitah2001@ yahoo.com.

Hauling/junk removal, next-day service, free phone estimate, 15% discount for all Hopkins. John, 443-682-4875.

Share furn’d Fells Point house (N Collington Ave), w/2 F SPH students, new W/D, lg, renov’d kitchen, BR is well lit w/new blinds and crpt, access to rooftop deck w/garden, nr waterfront/JHMI/downtown by public transportation, possibility to renew lease. $600/ mo + utils. Jordan, 303-257-2929.

Residential Brokerage Roland Park Office 410-235-4100

Studios - $595 - $630 1 BD Apts. - $710-740 2 BD from $795

on Hickory Avenue in Hampden!

2 BD units from $760 w/Balcony - $790!

Shown by appointment 410.764.7776 www.BrooksManagementCompany.com

Looking for tutor to teach Dutch, an eager student seeks patient tutor; also want complete Nikon Multiphot macro camera system or parts. jtvriv@hotmail.com. Responsible and loving pet-, baby- or housesitter avail, experienced w/special needs children and cats or dogs, refs avail. 202288-1311 or janyelle.thomas@gmail.com.

CARS FOR SALE

Horse boarding in Baltimore Co, beautiful trails in Greenspring and Worthington valleys from farm. $500/mo (stall board) and $250/mo (field board). 410-812-6716.

’89 Chevy 3/4 or 1-ton pickup truck, 4x4, rebuilt motor, new tires. $2,600. John, 443750-7750.

Certified prof’l career coach avail to provide coaching to students/young prof’ls. 410-375-4042 or mmoLten1@yahoo.com.

ITEMS FOR SALE

Clean up for winter, pet-friendly and reliable cleaning service, one time or wkly service, special rates. 443-528-3637.

Bicycles: one 18" Trek 7-spd, and one 20" Raleigh 10- or 12-spd; both recently insp’d. $200/ea or best offer. Charles, 410-9675388. Dark wood entertainment center, 68"H x 50"W x 17"D, $150; 4-drawer locking lateral file, 53”H x 42”W x 19.5”D, in great shape, $400. 443-690-7706 or jozsa@ quixnet.net. Beautiful sofa, in excel cond, lg entertainment system, 27" TV; buyer haul all three items. $165. rtr635@gmail.com. Oak entertainment center, $500; 1967 Wurlitzer Americana jukebox w/100+ 45 records; baby swing, like new, $55; Fender acoustic guitar, $200; best offers accepted. Chris, 443-326-7717. New exterior French doors, music cassette tapes, fitness chair, 21" TV, 35mm cameras, silk flowers and vase, Asian decor pillows, office file units, men’s travel bag, dining rm set, full-length silver fox coat, BlackBerry Bold accessories, other misc items. 443-8242198 or saleschick2011@hotmail.com. Sand beach chairs (2), inkjet printer, oilfilled heaters (3) and baseboard heaters (2), portable canvas chair, keyboard case, 100W amplifier. 410-455-5858 or iricse.its@ verizon.net. Conn alto saxophone, in excel cond. 410488-1886. Antique art deco furniture: 2 loveseats in eggplant velvet, $1,000/pair; 7-pc dining set, table, chairs, buffet, cabinet, gold oak w/red trim, $1,000. cgarvan@verizon.net.

SERVICES/ITEMS OFFERED OR WANTED

PT babysitter needed for Mt Washington–area family, must be responsible, excel driver w/own car, take kids to school AM, pick up late afternoon, lt cooking and

Transmission repairs, rebuilt or used, free estimate, 20% discount for all JHU employees, faculty, staff and students. 410-574-8822. Clarinet and piano lessons offered by Peabody master’s student. 240-994-6489 or hughsonjennifer@gmail.com. Piano lessons, patient instruction from experienced teacher w/Peabody doctorate. 410-662-7951. Matlab tutor avail (GUI, image processing, engineering), flexible schedule, rate varies case by case but low rate guaranteed. qhgb253@gmail.com. Chinese tutor available for students interested in learning the language. 443-956-4255. Masterpiece Landscaping: knowledgeable, experienced individual, on-site consultation, transplanting, bed preparation, installation, sm tree and shrub shaping; licensed. Terry, 410-652-3446. Tutor for all subjects/levels; remedial and gifted; also help w/college counseling, speech and essay writing, editing, proofreading. 410337-9877 (after 8pm) or i1__@hotmail.com. Affordable and professional landscaper/certified horticulturist available to maintain existing gardens, also designing, planting or masonry; free consultations. David, 410683-7373 or grogan.family@hotmail.com. Friday Night Swing Dance Club, open to public, great bands, no partners necessary. 410-663-0010 or www.fridaynightswing.com. Peabody grad avail for babysitting and/ or piano lessons, exp’d teaching young children and babysitting experience incls infants. lauren88s@yahoo.com. LSAT tutor avail, current SAIS student (score 174, admitted to Georgetown, Penn, Cornell, Duke), flexible schedule, avail at Balto and DC campuses. $50/hr (negotiable). 240-600-7265.

PLACING ADS Classified listings are a free service for current, full-time Hopkins faculty, staff and students only. Ads should adhere to these general guidelines:

HICKORY HEIGHTS WYMAN COURT Just Renovated! A lovely hilltop setting Beech Ave. adj. to JHU!

11

• One ad per person per week. A new request must be submitted for each issue. • Ads are limited to 20 words, including phone, fax and e-mail.

• We cannot use Johns Hopkins business phone numbers or e-mail addresses. • Submissions will be condensed at the editor’s discretion. • Deadline is at noon Monday, one week prior to the edition in which the ad is to be run. • Real estate listings may be offered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.) Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attachments) to gazads@jhu.edu; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Baltimore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 410-343-3362.


12 THE GAZETTE • November 7, 2011 N O V .

7

1 4

Calendar

B L OO D D R I V E S

Wed., Nov. 9, 8:30 a.m. to 2 p.m. JHU/American Red Cross

Blood Drive. For information, email johnshopkinsblooddrive@ jhmi.edu or call 410-614-0913. Johns Hopkins at Eastern.

L E C T URE S

The 2011 Samuel Iwry Lecture— “Books in Ancient Israel” by Alan Millard, University of Liverpool. Sponsored by Near Eastern Studies. 50 Gilman. HW

Mon., Nov. 7, 5:30 p.m.

COLLOQUIA Tues.,

Nov.

8,

4:15

p.m.

“Toward Understanding and Combating Bacterial Resistance to Aminoglycoside Antibiotics,” a Chemistry colloquium with Sylvie Garneau-Tsodikova, University of Michigan, LSI. 233 Remsen. HW “Relativistic Black Hole Tidal Disruption Events,” an STSci colloquium with Joshua Bloom, University of California, Berkeley. Bahcall Auditorium, Muller Bldg. HW

Wed., Nov. 9, 3:30 p.m.

Wed., Nov. 9, 5 to 7 p.m.

“Mood Disorders and Creativity,” a Peabody DMA Musicology colloquium with Kay Redfield Jamison, SoM. 308C Conservatory Bldg. Peabody “The Versatile Beta-Barrel Reveals Secrets of the Membrane,” a Biology colloquium with Karen Fleming, KSAS. Mudd Hall Auditorium.  HW

Wed., Nov. 9, 5:15 p.m.

“Supercapacitors,” a Physics and Astronomy colloquium with Boris Shklovskii, University of Minnesota. Schafler Auditorium, Bloomberg Center. HW

The 2011 Turnbull Lecture presents Irish literary critic and cultural commentator Edna Longley. Sponsored by the Writing Seminars. Mudd Auditorium. HW

Mon., Nov. 7, 6:30 p.m.

David Axelrod, senior strategist for Barack Obama’s presidential campaign and later his senior adviser in the White House, visits the Homewood campus this week to discuss ‘America’s Boundless Possibilities.’ See Special Events.

the conference will be available at https://connect.johnshopkins .edu/diversity. Shriver Hall Auditorium. HW Fri., Nov. 11, 12:15 to 2:15 p.m. “Community Case Manage-

ment of Pneumonia,” a JB Grant Global Health Society conference with a keynote address by Shamim Qazi, World Health Organization, and Asha George, SPH. One of a series of events in recognition of World Pneumonia Day, Nov. 12. E2030 SPH. EB

Thurs., Nov. 10, 3 p.m.

Thurs., Nov. 10, 3 p.m. “Diabetes and ‘Defective’ Genes in 20th-Century America,” a History of Science, Medicine and Technology colloquium with Arleen Tuchman, Vanderbilt University. Seminar Room, 3rd floor, Welch Medical Library. EB

C O N FERE N C E S Mon., Nov. 7, 9:30 a.m. to 4 p.m. The Five Elements of Civil

Society: A New Approach to Participation in Combating Trafficking, a SAIS Protection Project conference with a keynote address, “The Role Business Can Play to End Trafficking in Persons” by BeatheJeanette Lunde, Carlson Hotels. To RSVP, call 202-663-5896 or email ieLgiba1@jhu.edu. Kenney Auditorium, Nitze Bldg. SAIS

Wed., Nov. 9, 8:30 a.m. to 2:30 p.m. The 2011 Diversity Con-

ference—Diversity Still Matters: Perspective, Dialogue and Action with keynote address by Howard Ross. Following his address Ross will sign copies of his latest book, Reinventing Diversity: Transforming Organizational Community to Strengthen People, Purpose and Performance; copies will be available for sale. The conference will also include workshops covering diversity topics. Registration is closed, but a webcast of

the hospital and health system. The event will include advice and information from an expert panel, a meeting with a Benefits Office representatives, raffle prizes and refreshments. To register and for location information, go to www .hopkinsworklife.org/downloads/ JH_Baby_Shower_Registration_ Form.pdf or call the Office of Work, Life and Engagement at 443-997-7000.

DISCUSSIONS/ TALKS Mon.,

Nov.

7,

4:30

p.m.

“Tunisians and Their Hopes for Democracy: Toward Democracy,” a SAIS Conflict Management Program discussion with Hatem Bourial, Tunisian TV personality and author. Co-sponsored by the American Tunisian Association. To RSVP, email itlong@jhu.edu. 500 Bernstein-Offit Bldg. SAIS Mon., Nov. 7, 5 p.m. “Ancient Chinese Thought, Modern Chinese Power,” a SAIS China Studies Program discussion with Yan Xuetong, Tsinghua University, China. To RSVP, call 202-6635816 or email zji@jhu.edu. Kenney Auditorium, Nitze Bldg. SAIS Tu e s . ,

N o v.

8,

12:30

p.m.

“The European Financial Crisis and the American Recession: Which Way Out?” a SAIS Canadian Studies Program discussion with Anne Krueger, SAIS. To RSVP, call 202-663-5714 or email starr.lee@jhu.edu. Rome Auditorium. SAIS Tu e s . ,

N o v.

8,

4:30

p.m.

Deans’ Forum, a panel of SAIS deans will discuss their work and field questions from students. (Event is open to the SAIS community only.) Sponsored by the SAIS Student Government Association. For more information, email saissga@jhu.edu. Rome Auditorium. SAIS Wed.,

Nov.

9,

12:30

p.m.

“Emerging Africa: Rwanda, a

Case of a Top Reformer?” a SAIS African Studies Program discussion with Stephan Klingebiel, German Development Institute. For more information, call 202663-5676 or email itolber1@jhu .edu. 736 Bernstein-Offit Bldg.

‘After the Beautiful: Hegel and Pictorial Modernism’ , a

Humanities Center special series with Robert Pippin, University of Chicago. 208 Gilman. HW •

Tues., Nov. 8.

Wed., Nov. 9. “Philosophy and Art: Heidegger on Modernist Art.”

Thurs., Nov. 10.

SAIS

“The Ideological Contest in the Age of Arab Revolutions,” a SAIS Middle East Studies Program discussion with Thanassis Cambanis, Boston Globe columnist and correspondent for The Atlantic. (Event is open to the SAIS community only.). For more information, email katarina@jhu .edu. 507 Nitze Bldg. SAIS Wed., Nov. 9, 12:30 p.m.

“The Future of American Cities: Opportunities and Challenges,” a Center for Social Concern panel discussion on reduced immigration and diversity, population decline, African-American migration to the suburbs and the impact of the economy, with Trae Lewis, Baltimore Area Young Republicans; Willie Flowers, Park Heights Community Health Alliance; Donn Worgs, Towson University; and Tom Stosur, Baltimore City Planning Department. Moderated by Anthony McCarthy, WEAA 89.9 FM. (See In Brief, p. 2.) Glass Pavilion, Levering. HW Wed., Nov. 9, 7:30 p.m.

Thurs., Nov. 10, 12:30 p.m.

“The 2020 Oil Inflection Point,” a SAIS Energy, Resources and Environment Program discussion with James Lambright, Sapphire Energy. (The speaker’s comments will be off the record.) To RSVP, email eregloballeadersforum@jhu .edu. 500 Bernstein-Offit Bldg. SAIS

I N FOR M A T I O N SESSIONS

“Johns Hopkins Baby Shower,” learn about the services and programs available to expectant parents who are also full-time JHU faculty and staff or employees of

Tues., Nov. 8, 3 p.m.

“Politics and Ontology in Modern Art: Clark, Fried and Left-Hegelianism.”

Workshop: “Active and Passive Skepticism in Nicholas Ray’s In a Lonely Place: Some Themes From Cavell.”

Wed., Nov. 9, 12:30 p.m. “From the Black Movement’s Struggle to the Teaching of African and AfroBrazilian Histories in Brazil,” a Program in Latin American Studies lecture by Amilcar Araujo Pereira, Universidade Federal do Rio de Janeiro. Co-sponsored by Political Science. 388 Gilman. HW

The Annual Alvin H. Bernstein Lecture—“Three Great Captains of the Ancient World” by Barry Strauss, Cornell University. Sponsored by the Philip Merrill Center for Strategic Studies. To RSVP, call 202-663-5772 or email ckunkel@ jhu.edu. Kenney Auditorium, Nitze Bldg. SAIS

Wed., Nov. 9, 4:30 p.m.

Thurs., Nov. 10, 3 p.m. The 17th

Annual James F. Bell Memorial Lecture in Continuum Mechanics by Robert McMeeking, University of California, Santa Barbara. Sponsored by Mechanical Engineering. 210 Hodson. HW

“Lexicography of the Jewish Aramaic Dialects From Late Antiquity,” a Leonard and Helen R. Stulman Jewish Studies Program lecture by Michael Sokoloff, Bar Ilan University, Tel Aviv. Co-sponsored by Near Eastern Studies. 130G Gilman. HW Mon., Nov. 14, 3 p.m.

MUSIC

BMA Discovery Series presents The Johannes String Quartet. (See In Brief, p. 2.) Sponsored by the Shriver Hall Concert Series. $10 donation suggested. Baltimore Museum of Art. HW

Sat., Nov. 12, 3 p.m.

REA D I N G S / B OO K T A L K S

Reading by Irish poet Michael Longley. Mudd Hall Auditorium. HW

Tues., Nov. 8, 6:30 p.m.

Tues., Nov. 8, 7 p.m. Bestselling novelist and comedy writer Larry Doyle will read from and sign copies of his new book, Deliriously Happy and Other Bad Thoughts. Barnes & Noble Johns Hopkins. HW Thurs., Nov. 10, 6 to 8 p.m.

“Conquered Into Liberty,” Eliot Cohen of SAIS; Tom Ricks, ForeignPolicy.com and the Center for a New American Security; Nicholas Westbrook, director emeritus, Fort Ticonderoga; and Charles Doran (moderator) of SAIS will discuss Cohen’s new book, Conquered Into Liberty: Two Centuries of Battles Along the Great Warpath That Made the American Way of War. (See story, p. 9.) Sponsored by the SAIS Strategic Studies Program. To RSVP, email conquered.into .liberty2011@gmail.com. Kenney Auditorium, Nitze Bldg. SAIS Mon., Nov. 14, 12:30 to 2 p.m. Eamonn Gearon will dis-

cuss his new book, The Sahara: A Cultural History. Sponsored by the SAIS African Studies Program. For more information, call 202-663-5676 or email itolber1@jhu.edu. 500 Bernstein-Offit Bldg. SAIS S E M I N AR S Mon., Nov. 7, 9 a.m. “Evaluation of Multidisciplinary Palliative Care on Terminally Ill Cancer Patients in Taiwan,” a Health Policy and Management thesis defense seminar with Shao-Yi Cheng. W2303 SPH. EB

“Chromosome 5 and 7 Abnormalities in Oncology Personnel Handling Anti-Cancer Drugs,” a Johns Hopkins Education and Research Center for Occupational Safety and Health seminar with Melissa McDiarmid, University of Maryland School of Medicine. Lunch provided. W2030 SPH. EB

Mon., Nov. 7, noon.

“Chalk It Up to Biophysics,” an Institute for Biophysical Research seminar with Jon Lorsch, SoM. 111 Mergenthaler. HW

Mon., Nov. 7, noon.

Continued on page 8

(Events are free and Calendar open to the public Key except where indicated.) APL BRB CRB CSEB

Applied Physics Laboratory Broadway Research Building Cancer Research Building Computational Science and Engineering Building EB East Baltimore HW Homewood JHOC Johns Hopkins Outpatient Center KSAS Krieger School of Arts and Sciences NEB New Engineering Building PCTB Preclinical Teaching Building SAIS School of Advanced International Studies SoM School of Medicine SoN School of Nursing SPH School of Public Health WBSB Wood Basic Science Building WSE Whiting School of Engineering

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