Sildenafil/Viagra in the Treatment of Premature Ejaculation – A New Hope of Treatment
History of Sildenafil Citrate • Sildenafil Citrate100mg was first launched in April 1998 in the United States of America (USA), soon after the Food and Drug Administration (FDA) established approval, and is now extensively available all over the world. • More than $400 million worth of this medicine was sold in its first quarter on the USA market.
Definition of PE • Premature ejaculation (PE; lifelong and acquired) is a male sexual dysfunction with below mentioned features: • Ejaculation that always or nearly always occurs prior to or within about one minute of vaginal penetration (lifelong PE) or a noticeable and bothersome reduction in latency time, frequently to about ≤3 min (acquired PE). • The inability to delay ejaculation on all or nearly all vaginal penetrations. • Negative personal moments like distress, bother, frustration and/or the avoidance of sexual intimacy.
Rationale behind using Sildenafil in PE There are numerous mechanisms to clarify the effectiveness of sildenafil (PDE5-Is) for treatment of PE: • Mainly, through the nitric oxide/cGMP regulation • Smooth muscle relaxation in the tubes that carry sperms, relaxation of seminal vesicles (glands that secrete seminal fluid that nourishes sperms), prostate, and urethra and inhibition of adrenergic transmission. • Locally by prompting peripheral state of painlessness.
• Perpetuation of the duration of erection.
What does the current evidence say? • Sildenafil 100mg increased confidence, the perception of ejaculatory control, and overall sexual satisfaction. • Sildenafil was found effective and safe. More effective than paroxetine (medication used to treat PE) and squeeze technique.
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