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Volume 34

Issue 2, 2014

ISSX President’s Message By John O. Miners, ISSX President As a Society, ISSX is dependent on the commitment and goodwill of its members for its activities, including the organization of scientific meetings and the functioning of Council and committees. Several members of ISSX completed their terms on Council or ISSX committees at the end of 2013. In the last Newsletter, I acknowledged the contribution of retiring officers and councillors. I would also like to thank members who have completed their terms on various committees: Awards Committee - Chantal Guillemette and Paul Hollenberg; Finance Committee - Eric Johnson (chair) and Teruko Imai; Membership Affairs Committee Hugues Dolgos (chair); Scientific Affairs Committee - Aleksandra Galetin, Heyo Kroemer, Zhouhan Hu, and Mikihisa Takano. Scientific reach, the hosting of high quality meetings, and international– ization are core to the mission of ISSX. I am pleased to announce that ISSX Council has approved a collaboration with the International Transporter Consortium (ITC). The ITC is an alliance of academic, industry, and regulatory scientists with a

common interest in developing the science of drug transporters. As an expert group, the ITC will contribute to the planning and delivery of transporter sessions at ISSX meetings. The ITC-ISSX collaboration has many potential benefits given the importance of transporters in drug disposition and the interest of many ISSX members in transporter science.

meeting co-chairs, Professor Changxiao Liu and Dr. Zhuohan Hu, and their colleagues in CSSX for hosting a scientifically rewarding and socially enjoyable meeting.

As I indicated in the last newsletter, the two ISSX scientific meetings scheduled for 2014 will increase the international scope of the Society. The 5th Asia Pacific ISSX Meeting, which was held in Tianjin, China from May 9-12, was hosted by the Chinese Society for the Study of Xenobiotics (CSSX), our affiliate and partner in China. The meeting was a great success. There were 552 registrants representing seventeen different countries and approximately 300 poster abstracts. Congratulations go to Professor Yasushi Yamazoe and Dr. Kazuya Maeda, the respective recipients of the Asia Pacific Scientific Achievement Award and the New Investigator Award, who both gave presentations at the meeting. On behalf of ISSX, I wish to thank the

Registration is now open for our second meeting in 2014, the joint 19th North American ISSX / 29th JSSX Meeting which will be held in San Francisco October 19-23. The meeting co-chairs Drs. Eric Johnson and Tetsuya Terasaki and their colleagues on the Meeting Organizing Committee have developed an outstanding scientific program that can be accessed on the ISSX website. Please support this meeting by your attendance and don’t forget to renew your membership, which provides the added benefit of discounted meeting registration. John O. Miners President International Society for the Study of Xenobiotics

IN THIS ISSUE 1

ISSX President’s Message

2

Book Review: Natural Products Chemistry

Asia Pacific ISSX Meeting 3 5th Report

4

19th North American ISSX / 29th JSSX Meeting

6 In Memoriam: Garold Steven Yost 7 13th European ISSX Meeting


Book Review NATURAL PRODUCTS CHEMISTRY: Sources, Separations and Structures Authors: R. Cooper, G. Nicola CRC Press: Taylor and Francis 206pp, ISBN 13: 978-146-656761-0, 2014 The advent of synthesis, perhaps a couple of centuries ago, has enabled man to alter biologically-produced molecules, increase the availability of what otherwise may have been scarce materials, and generate molecular species that have not previously existed in the natural world. Whilst ingenious and laudable without doubt, these successes do sometimes overshadow the importance of the natural realm. As stated in the volume’s descriptive material, “compounds isolated from nature have long been known to possess biological profiles and pharmaceutical potential far greater than anything made by man.” In our present day repertoire of drugs, many can trace their ancestry back to compounds obtained from the biochemistry of the natural world.

This current book, “presents a practical guide to gathering, isolating, and discovering new pharmaceuticals from nature.” It is divided into ten chapters, with a few being sub-divided into sections. Some sections, such as that addressing the exploitative practice of “biopiracy,” were a welcome enlightenment to my naïve appreciation of mankind. To give an insight as to the coverage of this book, the chapter headings are listed as follows: History of natural products (terrestrial, marine, bioprospecting), Biological and pharmacological aspects, Fractionation and isolation, Structure elucidation (X-ray crystallography, NMR, mass spectrometry), Biosynthesis, Chemical synthesis (optimization for mass production and manufacturing), Medicinal applications, Integrating with systems biology (computational chemistry), Sustainability (biopiracy, environmental protection, international treaties), and Translation (curation and digitization, intellectual property, licensing and strategy).

The authors have produced an interesting work, with an easy-toread layout and many black and white illustrations (and a good cover) to enhance the volume. With the increasing importance of natural products as potential lead candidates in the (nearing frantic) search for new medicinal agents, the book is recommended for those who are involved in this arena, and that probably relates to most of us.

Reviewed by

Steve Mitchell Faculty of Medicine Imperial College London London SW7 2AZ, UK

Book ordering information:

CRC Press Taylor and Francis Group 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, Florida FL 33487-2742 Web: http://www.taylorandfrancis.com http://www.crcpress.com

ISSX Career Center

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Searching for experts in the field of drug metabolism, pharmacokinetics, pharmacodynamics, and other related areas? The ISSX Career Center job board is your premier resource to find skilled applicants. •C  reate your Company Profile free of charge and explain the organization and work environment in detail. •W  hen your positions are advertised on the ISSX Career Center, an e-mail advertising the position is sent automatically to job seekers who have requested notifications about opportunities matching their search criteria. • Browse résumés for free and pay only for the résumés that you select. Post your jobs online today! When you use the ISSX Career Center, you ensure that your open positions are advertised in the right place. Visit www.issx.org/careercenter.


5th Asia Pacific ISSX Meeting Report

The 5th Asia Pacific ISSX Meeting held May 9-12, 2014 in Tianjin, China attracted 552 attendees and was convened in a very pleasant and educationally conducive setting. Meeting Organizing Committee Chairs Professors Changxiao Liu, Zhuohan Hu, and John Miners welcomed the attendees at the opening session in the modern auditorium of the Binhai One Hot Springs Hotel. Attendees from nations including Australia, China, France, Hong Kong, Japan, Korea, Libya, Macau, Russia, Singapore, Sri Lanka, Sweden, Taiwan, Thailand, and the United States enjoyed 12 symposia sessions, two keynote addresses, three workshop sessions, and nearly 300 scientific posters during the four day meeting. ISSX gratefully acknowledges the contributions of the Meeting Organizing Committee, session chairs, speakers, poster presenters, exhibitors, and meeting attendees. It was an excellent meeting in all regards.

To view more photographs from this meeting, visit our web site at www.issx.smugmug.com.

Issue 2, 2014

19th North American ISSX and 29th JSSX Meeting Hilton San Francisco Union Square San Francisco, California, USA October 19–23, 2014

13th European Meeting University of Strathclyde Glasgow, Scotland, UK June 22–25, 2015

20th North American ISSX Meeting Hilton Orlando Bonnet Creek Orlando, Florida, USA October 17–21, 2015

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Upcoming Meetings


19th North American ISSX / 29th JSSX Meeting Planning and organizing for the 19th North American ISSX and 29th JSSX Meeting to convene October 19-23, 2014 in San Francisco is progressing exceptionally well. The scientific program offers interesting subject matter for everyone. Additionally, this meeting features more than 550 poster abstracts, an exhibition hall with more than 50 companies presenting their latest products and services, industry-sponsored symposia sessions, award lectures, and much more. ISSX is extremely pleased to co-organize a scientific meeting with the Japanese Society for the Study of Xenobiotics (JSSX). In 2005, ISSX partnered with JSSX to organize a highly regarded meeting in Maui, Hawaii. Another joint meeting between our societies offers a wonderful opportunity to provide researchers both fundamental new findings and cutting-edge information related to xenobiotic metabolism and disposition and demonstrates our continued mutual support. The meeting will begin on Sunday, October 19 with short courses on DDI prediction, metabolite biosynthesis and structure determination, Non-CYP metabolism, and a tutorial on using database mining to maximize the use of DMPK and DDI data during clinical development of new chemical entities. The short courses will be followed by a welcome reception for all attendees and registered guests.

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/ISSX Newsletter / Issue 2, 2014

The Hilton San Francisco Union Square Hotel is the home of the 19th North American ISSX/29th JSSX Meeting. We have reserved a block of hotel rooms for attendees of this meeting but you must act fast! Reservations for hotel accommodations at our reduced rate of $259 (exclusive of taxes) must be made by Monday, September 29. Located approximately 14 miles from San Francisco International Airport (SFO) and Oakland International Airport (OAK), the hotel is easily accessible by airport shuttle, public transportation, taxi, and rental car and features many services that will assuredly make your stay a pleasant one.

Hilton San Francisco Union Square Hotel 333 O’Farrell Street San Francisco, California 94102 USA Telephone: + 1(415) 771-1400 The meeting web site, www.issx.org/jssx-issx/hotel includes a link where attendees can access the JSSX/ISSX hotel accommodations reservations page to conveniently and securely reserve hotel accommodations at our group rate online. Alternatively, you may telephone the Central Reservations department at: +1 (855) 786-4701. The city of San Francisco is served by two major airports, an extensive public transportation system, and many private taxi, ferry, and shuttle services. For a complete list of transportation options in and around San Francisco, be sure to visit the meeting web site. San Francisco International Airport (SFO) offers nonstop flights to more than 74 cities in the US on 17 domestic airlines. Visit www.flysfo.com for up-to-theminute departure and arrival information, airport maps, and details on ground transportation and more. Oakland International Airport (OAK) is served by most major US carriers, with more than 150 daily departures. The site www.oaklandairport.com provides details about ground transportation from Oakland International Airport.


Depending on the agreements between the United States and your country, a visa may be required. Please check with your local embassy/consulate or travel agent to obtain information regarding visa requirements. To request a Letter of Invitation from JSSX/ISSX to help facilitate visa arrangements, please view the visa information page on the JSSX/ISSX web site at www.issx.org/visa.

including the Golden Gate Bridge, cable cars, the famous Lombard Street, Alcatraz, and much more. Its international airport is a major gateway to Asia with direct flights from more than 40 countries daily. We sincerely look forward to welcoming you to San Francisco in October for a sociallyrewarding and high-quality scientific meeting.

San Francisco is renowned for its steep rolling hills, eclectic architecture, and unique sights and sounds

Meeting Organizing Committee Eric Johnson, PhD (Meeting Co-Chair), The Scripps Research Institute Tetsuya Terasaki, PhD (Meeting CoChair), Tohoku University Kan Chiba, PhD, Chiba University Frank Gonzalez, PhD, National Cancer Institute Natalie Hosea, PhD, Pfizer Inc. Takashi Izumi, PhD, Daiichi Sankyo Co., Ltd. Paul Ortiz de Montellano, PhD, University of California, San Francisco R. Scott Obach, PhD, Pfizer Inc.

Bill Smith, PhD, Gilead Sciences Hiroshi Suzuki, PhD, The University of Tokyo Hospital Peter W. Swaan, PhD, University of Maryland Mikihisa Takano, PhD, Hiroshima University Ikumi Tamai, PhD, Kanazawa University Toshio Teramura, PhD, Astellas Pharma, Inc. Hiroshi Yamazaki, PhD, Showa Pharmaceutical University Xiao-bo Zhong, PhD, University of Connecticut School of Pharmacy

of San Francisco. Attendees will see the infamous Alcatraz Island with its former federal penitentiary, the magnificent Golden Gate Bridge, the art deco Coit Tower, the iconic Transamerica Building, and much more while enjoying an open bar and dinner buffet on the yacht. The yacht features three decks with heated indoor and outdoor areas, two marble dance floors, three bars, and plenty of windows to afford attendees with spectacular views.

Join us for the premier social event of the meeting – a dinner cruise on the yacht San Francisco Spirit on Wednesday, October 22!

We hope you will join us for this unique event. Purchase your ticket through the meeting registration site at www.issx.org/enroll.

Support ISSX! Renew with ISSX for the 2014 Membership term and save on your meeting registration for the upcoming 19th North American / 29th JSSX Meeting in San Francisco, CA this October! www.issx.org/renew.

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ISSX 2014 Membership

Issue 2, 2014

View the city lights and architecture as you cruise the bay

The dinner cruise is three hours long and motor coach transportation will be provided between the meeting hotel and Pier 3.


IN MEMORIAM Garold Steven Yost (1948–2014) Past ISSX Council Member and longtime ISSX member Dr. Garold (Gary) Steven Yost passed away on June 23, 2014. Gary graduated from Hesston Junior College with an Associate Degree in 1969. He earned his BS from Bethel College in 1971, MS Organic Chemistry from University of Hawaii in 1974, and his PHD in Organic Chemistry from Colorado State University in 1977. He did a Postdoctoral fellowship at the University of California San Francisco, had tenure track positions at Towson State University and Washington State University before becoming a tenured Professor of Pharmacology and Toxicology and an Adjunct Professor of Medicinal Chemistry at University of Utah in 1992. Gary belonged to numerous scientific, professional, and scholarly societies including the American Chemical Society, International Society for the Study of Xenobiotics, Society of Toxicology, and the Mountain West Society of Toxicology.

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Gary was the recipient of many awards and recognitions including the Zeneca Traveling Lectureship Award, the Colgate-Palmolive Traveling Lectureship from the Society of Toxicology, and was elected Fellow of the Academy of Toxicological Sciences in 2000 and elected to the Board of Directors from 2004-2007. He served on many national and international committees including the National Academy of Sciences/National Research Council Committee on Toxicology (Guidelines for developing spacecraft contaminants, U.S. Naval Medical Research Toxicology Program, Subcommittee on Rocket-Emission Toxicants). He also served on numerous editorial boards.

Gary loved his profession. He was an outstanding scientist with an international reputation for excellence. He was an excellent mentor and lecturer for many doctoral candidates, pharmacy and medical students. His influence will continue to be a force in his scientific field and from his association with his students and family.


Make Plans to Attend the 13th European ISSX Meeting June 22-25, 2015 The University of Strathclyde • Glasgow, Scotland

Features of this Meeting The meeting will include short courses, keynote lectures delivered by leading researchers, parallel sessions on a wide range of topics, poster sessions, awards presentations, and a trade exhibition. There will be multiple opportunities for attendees to enjoy scientific and social interaction with friends and colleagues in a purpose-built conference facility in the centre of Glasgow.

is a wonderful city to visit. It provides an excellent launching point for exploring the other many sights to see in Scotland. Watch for communications from ISSX regarding abstract submission, how to nominate a deserving candidate for the European Scientific Achievement Award or European New Investigator Award in Honor of Karl J. Netter, registration and exhibition information, and much more! Be certain to include this outstanding scientific meeting in an easily accessible location in Europe in your department’s budget and make plans to join us in Glasgow, Scotland June, 22-25, 2015. The abstract submission site for this meeting opens on October 1, 2014. Watch your email for more information!

Meeting Organizing Committee Co-Chairs:

Meeting Venue

Ann Daly, Newcastle University Roland Wolf, University of Dundee

The 13th European ISSX Meeting will convene in a new state-of-the-art facility on the campus of the University of Strathclyde which is located in centre city Glasgow. Both university housing and business hotels will be available for attendees.

Meeting Organizing Committee:

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There is much to see in and around Glasgow. Stately homes and museums like the Burrell Collection and Kelvingrove Art Gallery & Museum should not be missed. And with Loch Lomond just half an hour away, there is plenty of breathtaking scenery to enjoy too. Glasgow also has great shopping and inspiring architecture and

Issue 2, 2014

Glasgow is easily accessed from two main airports close to the city: Glasgow International Airport and Glasgow Prestwick International Airport. Edinburgh Airport is only 40 miles away.

John Hayes, University of Dundee Brian Houston, University of Manchester Neil Kitteringham, University of Liverpool Michael McMahon, University of Dundee Richard Meehan, University of Edinburgh Munir Pirmohamed, University of Liverpool Colin Suckling, University of Strathclyde Geoff Tucker, University of Sheffield Michael Voice, Cypex, Dundee Heather Wallace, University of Aberdeen Matt Wright, Newcastle University


ISSX depends on the support of its members to help us organize our educational activities and to sustain our operations. Please respond to the membership dues notices that will be distributed in late October. Membership dues remain unchanged and go far towards helping us achieve our goals.

ISSX members  have  access  to  a  variety  of  exclusive  benefits  including:   A  Subscription  to  the  ISSX  Newsletter  -­‐  Members  receive  a  quarterly  newsletter  that  highlights  Society  news,   member  spotlights,  upcoming  meetings,  late  breaking  scientific  news,  and  much  more.   Reduced  Registration  Fees  -­‐  Members  receive  significant  discounts  on  registration  fees  for  all  ISSX  meetings   and  workshops.   Recorded  Educational  Content  -­‐  New  in  2014  -­‐  Members  can  access  recorded  content  online  at  a  reduced   members-­‐only  rate.   Abstract  Presentations  -­‐  Members  have  the  opportunity  to  submit  abstracts  to  present  their  work  with  other   leaders  in  the  field  at  ISSX  meetings.   Searchable  Meeting  Abstracts  -­‐  Members  may  perform  searches  for  and  cite  abstracts  from  past  ISSX   meetings.     Networking  Opportunities  -­‐  Meet  with  other  local  and  international  leaders  interested  in  DMPK.   Society  Awards  Program  -­‐  Only  ISSX  members  are  eligible  for  the  prestigious  Scientific  Achievement  Awards   presented  at  our  regional  meetings.   Travel  Grants  -­‐  Eligible  members  may  apply  for  travel  assistance  to  attend  ISSX  regional  and  international   meetings.   Membership  Directory  -­‐  Our  searchable  online  membership  directory  makes  connecting  with  fellow   researchers  convenient.   Special  Journal  Subscription  Discounts  -­‐  Members  receive  special  subscription  discounts  to  multiple  scientific   journals,  including  Drug  Metabolism  Reviews,  Annual  Review  of  Pharmacology  and  Toxicology,  and  many   more.     Hold  Office  and  Serve  on  a  Committee  -­‐  Holding  a  position  of  leadership  in  ISSX  is  a  tremendous  opportunity   to  serve  your  peers  worldwide,  to  develop  important  skills,  help  set  the  work  plan  of  a  prestigious  international   scientific  society,  and  be  recognized  as  a  leader  volunteer  of  an  international  scientific  society.   Vote  in  ISSX  Elections  -­‐  Helping  to  choose  the  future  leaders  of  ISSX  sets  the  path  of  our  organization  and   provides  you  the  opportunity  to  elect  those  who  best  represent  your  interests.         Most   of  all,  your  membership  indicates  your  support  of  our  mission  to  advance  the  understanding  of   the  interactions  of  medicines  and  chemicals  with  living  systems  and  helps  sustain  our  program  of   operations.    Please  support  ISSX  by  renewing  your  membership  today!  

www.issx.org/membership/renew


Change of Address

ISSX Newsletter is published quarterly in the spring, summer, autumn, and winter. For information concerning advertising in this publication, including rates and specifications, please visit www.issx.org or contact information@issx.org.

If your mailing address, telephone, fax number, or e-mail has changed or will change, please let us know as soon as possible. You may update your contact information at any time using the online membership directory, which you can access in the Member Only section of the Web site. If you have forgotten your username and/or password, please contact information@issx.org.

Advertise with ISSX in the quarterly ISSX Newsletter. Rates and additional advertising opportunities are available at www.issx.org/advertising2014.

Deadline for the submission* of material to the ISSX Office: ISSUE MATERIALS DEADLINE RELEASE DATE Pre-Meeting Issue

August 15, 2014

September 2014

Issue 4, 2014

November 14, 2014

December 2014

*

Subject to change

Editor Dr. Allen Cato, III Cato Research, LTD 6480 Weathers Place, Suite 104 San Diego, California 92121 USA Telephone: +1-858-452-7271 Fax: +1-858-452-7784 E-mail: jcato@cato.com

Advertise with ISSX The quarterly ISSX Newsletter is an online publication featuring Society updates, scientific articles of interest, book reviews, summaries of ISSX meeting proceedings, and more. This publication is designed to update the ISSX membership on the activities and events of the organization and to provide an information forum. Not only is the ISSX Newsletter promoted directly to all ISSX Members, but, as of 2012, it is also available to anyone who visits the ISSX Web site. Visit www.issx.org/advertising2014 today!

ISSX Newsletter Issue 2, 2014  
ISSX Newsletter Issue 2, 2014  

ISSX News, Letter from ISSX President, Book Review, 5th Asia Pacific Meeting Report, 19th North American ISSX / 29th JSSX Meeting, 13th Euro...