InfiniWell Practitioner Catalogue

Exact Pax™ FOUNDATIONAL

Thisall-inclusive, meticulously curatedselection of essential components is specifically designed to empower patients' overall well-being by nurturing crucial physiologicalsystems. From fortifyed bone healthtooptimizedimmunefunction,oursynergistic blend of Vitamin A, Vitamin D, Vitamin K2 MK-7, and well-absorbed Di-Magnesium Malate support neurological vitality and cardiovascular resilience through our Methylated B-Complex and Evonik's AvailOm® High Potency EPA. this packet offers a holistic approach to health maintenance.

FOUNDATIONAL

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN

BENEFITS

PATIENTS REQUIRING

• Cardiometabolic Support

• Bone health Support

• Immune Support

• Sex Hormone Metabolism Support

Supports Immune Function & Immune Cell Activation

Supports Strong Bones, Calcium Absorption & Metabolism

Supports Cardiovascular Function

Supports Neurological Function & Methylation Optimization ABOUT ExactPax"' - ---------

Personalized Packets Based on Specific Health Goals

Based on the gracious input and ordering patterns of thousands of Infiniwell physicians, we created the ExactPax™ line. Each ExactPax'" box includes a one-month supply of convenient, individual daily supplement packets. compiled from the most popular bundles purchased for each identified health goal.

Convenient Reordering

Eliminated Guesswork

BestPracticeProtocols

Better Compliance

Forgetmessybottles.Reordering Simplifyyourpatients· daily Keepyourpatientsup-to-date Having betterpatient isautomated,whichmakesthe healthroutine.Patientswillno with the best &latestpractice complianceequatestobetter conveniencenight &dayin longerneedtorememberwhen, protocolsbeingimplemented resultsforbothyourpatients comparisontomanagingbottles. howmuch,orwhattotake. byspecialists. andyourpractice.

FOUNDATIONAL vs. FOUNDATIONAL+

FOUNDATIONAL lx Defend 2x Activated Magnesium

lx Methylated B-Complex 2x Omega Sx

6 Capsules/Packet

1 x Defend

SUPPLEMENT FACTS

ServingSize:1Capsule I ServingsPerContainer:30

AmountPerServing %DV

VitaminA (asretinylpalmitate)(5,000IU) 1515mcg

VitaminD(as Vitamin03,cholecalciferol) 125mcg (5,000 IU)

VitaminE(asd-alphatocopherolsuccinate) (121IU) 100mg

VitaminK2MK-7(asK2VITAL0 DELTA 200mcg All-Trans Menaquinone-7)

AstraGin"(Astragalusmembranaceus 50mg andPanaxnotoginseng)RootExtracts

•DailyValueNotEstablished

OtherIngredients:Nuflow,VegetableCapsule (Hypromellose)

BOTH INCLUDE

2xActivated Magnesium 1 xMethylated B-Complex

SUPPLEMENT FACTS

ServingSize:2Capsules ServingsPerContainer.30

Amount Per Serving %DV

Magnesium 250mg 59% (asAlbionDi-MagnesiumMa/ateand TRAACS® MagnesiumLysinateG/ycianteChelate)

MalieAcid 828mg (asAlbionDi-MagnesiumMa/ate)

*DailyValueNotEstablished

OtherIngredients:RicePowder,Hydroxypropyl Methycellulose,MagnesiumStearate,Silicon Dioxide,VegetableCapsule(Hypromellose)

SUGGESTEDUSE

lx Defend Pro

2x Activated Magnesium

lx Methylated a-complex

2x Omega Sx

6 Capsules/Packet

1 x Defend Pro

SUPPLEMENT FACTS

ServingSize:1Capsule ServingsPerContainer:30 Amount

VitaminA(asretinylpalmitate)(5,000 IU) 1515mcg

VitaminD(as Vitamin03,cholecalciferol) 250mcg (10,000IU)

VitaminE(asd-alphatocopherol succinate) 100mg (121IU)

VitaminK2MK-7 (asK2VITAL0DELTA 300mcg

All-TransMenaquinone-7)

AstraGin"(Astragalusmembranaceus 50mg andPanaxnotoginseng) RootExtracts

*DailyValueNotEstablished

OtherIngredients:Nuflow,VegetableCapsule (Hypromellose) 2xOmegaSX

SUPPLEMENT FACTS SUPPLEMENT FACTS

ServingSize:1Capsule ServingsPerContainer:30

VitaminBl (as ThiamineHCL) 50mg

VitaminB2(asRiboflavin) 50mg

Niacin(asNiacinamide) 50mg

VitaminB6(asPyridoxineHCL) 50mg

Folate (asS-Methyltetrahydrofo/icAcid) 680mcg

VitaminB12(asMethy/cobalamin) 500mcg

Biotin 75mcg

PantothenicAcid/as[).(afunPantothenateJ50mg

Choline/as CholineBitartrate) 19mg

Inositol 50mg

*DailyValueNotEstablished 4,167%

.

otherIngredients:HydroxypropylMethycellulose, MagnesiumStearate,SiliconDioxide,Vegetable Capsule(Hypromellose)

Take 1 packet daily, with a meal, or as directed by your healthcare practitioner.

ServingSize:2CapsulesIServingsPerContainer.30

Amount Per Serving %0V

Omega-3LysineComplex (AvailOM0) (Providing360mgEPA, 1200mg * 180mgDHA)(asFreeFattyAcids)

SmartPrime-Om™ Complex 250mg * [MethyfsulfonyfmethaneandSesameseed (SesamumindicumL)extractstd. forSesamin]

AstraGin•(Astragafusmembranaceusand 50mg * Panaxnotoginseng) RootExtracts

*DailyValueNotEstablished

OtherIngredients:MagnesiumStearate(Vegetable), Silica,VegetableCapsule(Hypromellose) Contains Fish

CONTENTS

Defend / Defend Pro

Defend features vitamins A, 5000 IU of D3, and K2. Defend Pro also features vitaminA but includes 10,000 IU of D3 and K2. alI of which are essentialnutrients that play important roles in variousbiologicalprocesses. Vitamin A is important for vision, immune function, and cellular growth and differentiation. Vitamin Dis essential for bone health, immune function, and has beenlinked to numerousotherhealthbenefits.Vitamin K2 is necessary forproperblood clotting and has beenlinked to improved bone health and cardiovascular health. Since these three nutrients work together to depend on one another, their combination in a dietary supplement is key. AstraGin® . a proprietary blend of Astragalus membranaceus and Panax notoginseng extracts. serves to improve nutrient absorption and enhance the bioavail ability of certain compounds, these vitamins included. When combined, these nutrients and AstraGin® can create a synergistic effect, potentially enhancing their individual benefits and improving overall health.

• Supports immune function

• Supports effective calcium deposition

• Supports cardiometabolic function

• Supports optimal hormone metabolism

Activated Magnesium

Magnesium isinvolvedin over 200 essential biochemical reactions withinthe human body. It serves as acofactorfor numerous enzymes, facilitating various metabolic processes. These reactions include energy production, as magnesium is crucial for the synthesis of adenosine triphosphate (ATP). the primary energy currency of cells. Magnesium also plays a key role in protein synthesis, DNA and RNA synthesis, and cellular replication. Additionally, it is involved in maintaining proper nerve and muscle function; regulating blood pressure; supporting cardiovascular health; participating in the metabolism of carbohydrates, fats, and proteins; and aiding in the synthesis of neurotransmitters. Moreover, magnesium contributes to the activation of vitamin Dand helps maintain bone health. Its extensive involvement in such a wide array of physiological processes underscores its indispensability for overall well-being and optimal bodily function.

• Supports healthy neurotransmitter metabolism

• Promotes vascular relaxation and pliability

Methylated B-Complex

• Maintains healthy levels of melatonin

• Aids in healthy levels of ATP production

A diverse and intricate range of B vitamins is crucial for the body's ability to transform food into energy at the cellular level. These vitamins, which are soluble in water, are initially absorbed in the small intestine and then transported to the liver, where they undergo biotransformation into their coenzyme forms. One of the primary functions of B vitamins is to act as essential coenzymes in the Kreb's cycle, a biochemical pathway responsible for sustaining energy production in the form of adenosine triphosphate (ATP). which is vital for cellular energy. Additionally, B vitamins, particularly folate, B6, and B12, play a significant role in proper methylation: a biochemical process that facilitates the conversion of the problematic amino acid metabolite and homocysteine, into the amino acids methionine and cysteine.Adequate methylation is crucial for supporting various aspects of mental and physical health, including the regulation of gene expression and DNA repair.

• Supports healthy methylation & carbohydrate metabolism

• Promotes nervous system, immune & adrenal health

• Supportsneurotransmitterproductionfor a positivemood

• Protects against stress-induced nutrient depletion

DELTA

Omega5X

The dietary supplement market is flooded with products that promise to enhance overall health and well-being. However, not all supplements are created equal, and many fail to deliver on their promises. Omega SX is a unique supplement designed to enhance the delivery and increase the bioavailability of omega-3 fatty acids. We all know the role that omega-3 fatty acids play and their crucial role in maintaining the health of varioussystems in the body, but their bioavailability can be limited. Omega SX combines three key ingredients, AvailOm® High Potency EPA. SmartPrime-Om™ . and AstraGin® to provide a powerful combination of omega-3 fatty acids, MSM, sesame oil, and a patented blend of natural plant extracts that work together to maximize the bioavailability of omega-3 fatty acids in the body.

•Cardiometabolic support

• High potency EPA omega-3's

Avail□m® IIsma�-�p:.!�.�-□m

AnEvonikprodu<:t. trademark licensed by NPI, LLC.

WHEN TO RECOMMEND(+)

• Neurological and mood support

•Joint mobility and tissue integrity

Generally speaking, the patient who is looking to cover any potential nutritional gaps and provide themselves with optimal foundational nourishment would be the ideal person for a Foundational ExactPax™ recommendation.

When it comes to those patients who have similar nutritional goals but who want more intense immune, bone and heart support or simply desire a greater level of Vitamin D, the Foundational Foundational+ ExactPax™ is the more appropriate option.

INDIVIDUAL BOTTLES

A KKERMANSIA-BPC-COMPLEX

Prebiotic | Live Probiotic | Peptide*

ABC (Akkermansia-BPC-Complex) provides a new approach to cellular longevity via gut health and metabolic optimization. Informed by the latest research on microbiome profiles in Centenarians. This "first-of-it's-kind" formulation is at the cutting edge of longevity science. Two primary areas emerge from the data as being critical for longevity: gut barrier integrity and metabolic function, especially as it relates to GLP-1. ABC is designed specifically to harness the synergistic power of Akkermansia, BPC-157, and Sunfiber® to support metabolic optimization and microbiome profiles found amongst blue zone Centenarians.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMENPATIENTS REQUIRING

•Comprehensive Digestive Support

•Metabolic, Specifically GLP-1, Support

•Gut-Brain Axis Maintenance

•Intestinal Permeability Support

BENEFITS

Supports Healthy Gut Microbiota Aids in Optimizing Gut Barrier Integrity

Helps Promote GLP-1 Production

Promotes Leaner Body Composition

DIRECTIONS:

Take 1-2 capsules two times daily or as directed by your healthcare practitioner.

AKKERMANSIA & BPC- 157 BASICS

First, it is important to understand the biochemical role Akkermansia muciniphila plays in the gut as it relates to metabolic health. It all comes down to its interactions with glucagon-like peptide-1 (GLP-1), an important hormone produced by the intestinal cells, which plays a vital role in regulating glucose metabolism and insulin secretion. Akkermansia muciniphila is known to facilitate the natural production and secretion of GLP-1 in the intestine by utilizing mucin, a glycoprotein present in the mucus lining of the gut. as its primary source of energy.1 During the process of mucin degradation, Akkermansia releases metabolites that stimulate the intestinal L-cells to secrete more GLP-1.2 The increased levels of GLP-1 then act on various tissues, such as the pancreas, liver, and muscles, to promote glucose metabolism, support insulin sensitivity, and regulate appetite. ultimately contributing to overall metabolic health.3

BPC-157, on the other hand, plays an important supporting role via its effects on gut tissue and barrier integrity. This peptide is responsible for maintaining and continuously supporting the intestinal architecture. which allows the myriad of chemical interactions to occur without interruption within the gut ecosystem

BPC- 157 / AKKERMANSIA SYNERGY

Because the biochemical relationship between Akkermansia and the intestinal barrier is heavily dependent on a high level of structural integrity within the gut lining, BPC-157 serves as the ideal companion. As BPC-157 plays a vital role in rejuvenating and maintaining gut tissues, supporting barrier function, it creates the optimaI environment for Akkermansia's broad biochemical function.

Additionally, Sunfiber serves as a rich prebiotic source for short-chain fatty acid production, in particular butyrate. As a trio, they all work in harmony to support a healthy gut microbiome, improve nutrient absorption and optimize metabolic function. This synergistic interaction lays the foundation for longevity by fostering a resilient gut environment that contributes to overall healthspan and vitality.

CENTENARIAN INSIGHT

The most recent microbiome study in centenarians revealed fascinating insights into the gut microbiota of these long-lived individuals. One of the key findings was the abundance of Akkermansia muciniphila in the centenarian microbiome. 4 The article went on to state, ‘In addition, a high abundance of Akkermansia is a significant characteristic of elderly populations with low BMI values. Furthermore, the functional prediction results showed that the elderly longevity group had higher abilities in short-chain fatty acid metabolism, amino acid metabolism, and xenobiotic biodegradation.’ 4 The findings underscore the importance of Akkermansia in longevity and offer valuable insights into potential strategies for enhancing gut microbiome resilience and longevity in aging populations.

REFERENCES

2. 3. 4. Derrien, M. et al. (2004). Bulletin of the IDF, 388, pp.107-112.

Plovier. H. et al. (2017). Nature Medicine, 23(1), pp.107-113.

Baothman OA, Zamzami MA, Ta her I, Abu baker J, Abu-Farha M. Lipids Health Dis. 2016 Jun 18;15:108.

Ai X. Liu Y. Shi J, Xie X, Li L, Duan R. Lv Y, Xiong K. Miao Y, Zhang Y. Appl Microbial Biotechnol. 2024 Apr 15;108(1):300

REFERENCES

1. Salve J, Pate S, Debnath K, LangadeD. Adaptogenic andAnxiolytic Effects of Ashwagandha Root Extract in HealthyAdults: A Double-blind, Randomized, Placebo-controlledClinical Study. Cureus. 2019 Dec 25;ll(l2):e6466. doi: 10.7759/cureus.6466. PMID: 32021735; PMCID: PMC6979308.

2. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relievingand pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlledstudy. Medicine (Baltimore). 2019 Sep;98(37):el7186. doi: 10.1097/MD.0000000000017186. PMID: 31517876; PMCID: PMC6750292.

3. Sharma AK, Basu I, Singh S. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. J A/tern Complement Med. 2018 Mar;24(3):243-248. doi: 10.1089/acm.2017.0183. Epub 2017 Aug 22. PMID: 28829155.

4. Candelario M, Cuellar E, Reyes-Ruiz JM, Darabedian N, Feimeng Z, Miledi R, Russo-Neustadt A, Limon A. Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAp receptors. J Ethnopharmacol. 2015 Aug 2;171:264-72. doi: l0.1016/jJep.2015.05.058. Epub 2015 Jun 9. PMID: 26068424.

5. Barua A, Bradaric MJ, Bitterman P, Abramowicz JS, Sharma S, Basu S, Lopez H, Bahr JM. Dietary supplementation of Ashwagandha (Withania somnifera, Dunal) enhances NK cell function in ovarian tumors in thelaying henmodel of spontaneous ovarian cancer. Am J Reprod lmmunol. 2013 Dec;70(6):538-50. doi: 10.1111/aji.12172. Epub 2013 Nov 5. PM/D: 24188693.

6. Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):208-13. doi: 10.4314/ajtcam.v8i5S.9. Epub 2011Jul 3. PM/D: 22754076; PMC/D: PMC3252722.

BPC-157

Muscle, Joint & Gut Support*

BPC-157 is predominately indicated for patients who need joint and/or digestive (upper/lower) support.

There are two levels available: a 250 mcg dose, ideal for patients needing maintenance; and a 500 mcg dose, a higher potency that can be leveraged to cases where more support is needed.

There are two time-release formula options: rapid and delayed. The rapid release formula is typically for upper GI application. Regarding joint health, rapid release is more appropriate for acute needs, while the delayed release works for more ongoing support. The delayed release formula is intended to reach the lower intestines without succumbing to the harsh environment of the upper digestive system.

Historically, peptides have been notoriously difficult to absorb orally.

Throughout the entire BPC-157 line, it is important to note the addition of Salcaprozate Sodium (SNAC), which works to enhance absorption and support the body's ability to utilize the desired serving dosage at the required time.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMENPATIENTS REQUIRING

•Digestive Support; Both Upper & Lower

•Musculoskeletal Support

•Gut Brain Axis Protocols

•Immune System Support

BENEFITS

Joint and Soft Tissue Support

Neurological Support

Promotes Digestive Function

Optimize Nitric Oxide Production

DIRECTIONS:

Take 1 capsule twice daily or as directed by your healthcare practitioner.

REFERENCES

1. White DJ, de Klerk S,et al. Anti-Stress, Behavioural and MagnetoencephalographyEffectsofan L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, PlacebciillControlled, Crossover Trial. Nutrients. 2016;8(1):53.doi:10.3390/nu80l0053.

2. Higashiyama A. HtayHH,et al., Effectsof L-theanine on attention and reaction time response, Journal of Functional Foods.2011; doi:10.1016/jJ.2011.03.009.

3. Lopresti, A. L, Smith, S.J., Ali, S.,Metse, A. P., Kalns, J.,&Drummond, P. D. (2021). EffectsofaBacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods,85,104671. ISSN 1756-4646.https://doi.org/10.1016/jJff.2021.104671.

4. Best T, Clarke C,NuzumN, Teo WP. Acuteeffectsof combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic responseofthe prefrontal cortex:a double-blind, placebo-controlled study. Nutr Neurosci. 2021Nov;24(11):873-884. doi: 10.1080/l028415X.2019.1690288.Epub2019 Nov 18. PMID: 31736428.https://doi.org/J0.1080/l028415x.2019.1690288.

5. Maruyama Y, Kuribara H, Kishi E, Weintraub ST, Ito Y. Confirmation ofthe anxiolytic-like effectof dihydrohonokiol following behavioural and biochemical assessments.JPharm Pharmacol. 2001May;53(5):721-5. doi: J0.1211/0022357011775848.PMID:11370711.https://doi.org/J0.1211/0022357011775848

6. Kuribara H, Kishi E, Kimura M, Weintraub ST, Maruyama Y. Comparative assessmentofthe anxiolytic-like activities of honokiol and derivatives. Pharmacol Biochem Behav. 2000Nov;67(3):597-601. doi: 10.1016/s0091-3057(00)00401-9. PMID: 11164091.https://doi.org/J0.1016/s0091-3057(00)00401-9

7. Woodbury, A., Yu,S.P., Wei, L,& Garcia, P. (2013). Neuro-Modulating Effectsof Honokiol: A Review. Frontiers in Neurology, 4,130. https://doi.org/10.3389/fneur.2013.00130

INGREDIENTS

NADl

The first, and perhaps mostcutting-edge inclusion, is the NAD3® This is a multi patents-pending nutraceutical containing a unique Wasabijaponica extract, Theacrine. and Copper(l)-Niacin complex. Preliminary pre-clinical and human studies. in collaborationwiththe DNA methylation and epigeneticexpertsatTruDiagnostic andthe multi-omics Molecularand Applied Sciences Laboratory at Auburn University, suggestthemechanism bywhichthis trio works is by upregulating enzymes that facilitate the conversion ofNAD+ precursors. such asNiacin. Niacinamide, Nicotinamide Riboside(NR) and/orNMN to NAD+. whilealsosuppressingtheactivityofproteinsthatdeplete & consumeNAD+. Collectively,thesedatasupporttheuseofNAD3® incombinationwithanyNAD+precursoror"booster" (asanidealcompanion)forsupportingnetcellularNAD+status.

In vitro AND in vivo human clinicaldatafrom the recently completed 'ENHANCE Trial' of NAD3® supports the hypothesis that cellularNAD+concentrationaloneisnotthelinchpintolongevity. Instead,thereappearstobea"leakysink"wherebyNAD+levels decreaseduetochronicinflammationandaberrantimmuneactivation.NAD+depletioncouldbelimitedbycontrollingsystemic inflammation and keeping NAD+ salvage pathways active. Thus, onestrategyto enhance longevity appears to be providing sufficientNADprecursorforsalvagepathways,plusactivatingthedownstreamstressresilienceandpro-longevitygenenetworks (e.g.,SIRT3/6, SOD3, TERF1/POTI.CCL3, CXCL9, PGC1-A. SOX2/KLF4,etc.).Moreover,humandatawithoralsupplementationofNAD3® for 12weeksdemonstratedtheabilitytosupportvariousindependentcardiovascularriskfactorssuchasVLDL,TAGs, LDL-C,and TotalCholesterol.Inthesamestudy,beneficialchangesinintracellularNAD+levelswerenoted, eventhoughNAD3® does NOT containanappreciabledoseofNAD/B3vitaminprecursor.Takentogetherthepre-clinical,mechanisticdataonNAD3® (andits constituents,theacrine,long-chainallyl,andphenethyl ITC-richWasabiextract)andfirst-in-humanENHANCE Trialdataprovide asolidbasisforNAD3®aspartofacomprehensiveplantooptimizecardiometabolichealthandlongevity.'

•••• NSK-so�"

NSK-SD® Nattokinase - The second ingredient is a proteolytic enzyme. which operates very differently from a digestive enzyme in the body. Proteolytic enzymes work systemically. outside the confines of the digestive system. and protect against excessive fibrin formation and accumulation (fibrin being converted from fibrinogen, which excessive amounts of inflammation can trigger among other things, and at high levels can wreak havoc on the cardiovascular system via excessive clotting of blood). This enzyme, NSK-SD® , is a patented, branded, uniquely produced, and extensively studied enzyme. NSK-SD® is isolated from natto, a food made from fermented soybeans.

Thisenzymehasdemonstrated,quite consistently, its abilitytopositivelyimpactcardiovascularhealth.Clinicalresearch showing thephysiologicalandbiochemicalbenefitsof NSK-SD® highlighted in over 30+publishedstudies in the areas of supporting healthy blood pressure, providing critical fibrinolytic activity to mitigate excessive blood clotting while not inhibitingwoundhealing,supportinghealthylevelsofplateletand red blood cellaggregationas well as blood viscosity.2•3

Bergamot

Citrus bergamia. known as Bergamot, a fragrantfruit the size of an orangewith a yellow color similar to a lemon is included in this formulation. It's been clinically shown to support heart health by promoting healthy cholesterol. blood sugar. and triglyceride levels and supporting blood vessel function.4

OnenovelmechanismbywhichBergamotworks isthroughitsabilitytoactivateAMPK. Intermsofbloodsugar,andincidentally insulinlevels, this is typicallyseenastheprimarymechanism. Its activationofAMPKcombinedwiththestructural similarities to other HMG Co-A reductase inhibitors, has ledto the theorized mechanism bywhichBergamot can support healthy levels of cholesterol production.

REFERENCES

1. Roberts MD,OsburnSC, GodwinJS, Ruple BA, La MonicaMB, RaubB, SandrockJE, ZiegenfussTN, LopezHL EnhanceTrial: Effectsof NAD3"' on Hallmarks ofAgingand Clinical Endpointsof Healthin Middle AgedAdults: ASubsetAnalysisFocusedon Blood Cell NAO+ Concentrations and LipidMetabolism. Physio/ogia.2022;2(1):20-31.https://doi.org/10.3390/physio/ogia2010002

2. SumiH, Hamada H,Nakanishi K, etal. Enhancementofthefibrino/yticactivityinplasma byoral administrationofnattokinase.Acta Haemato/ 1990;84:139-43.DOI: 10.1159/000205051

3. SumiH, Hamada H,TsushimaH,etal. A novelfibrino/yticenzyme(nattokinase)inthevegetablecheeseNatto;atypicaland popularsoybeanfood intheJapanesediet. Experientia1987;43:1110-1.DO/:10.1007/BF01956052

4. Ross Walker, E/zbieta Janda and Vincenzo Mo/lace. The UseofBergamot-derivedPolyphenol Fraction inCardiometabolic Risk Preventionandits Possible MechanismsofAction.Cardiac Healthand Polyphenols. Chp84, Pg 1085-1103,2014. http://dx.doi.org/J0.1016/B978-0-12-398456-2.00084-0

5. Micaela Gliozzi. Ross Walker. E/zbjeta Janda, Vincenzo Mo/lace. Bergamot polyphenolic fraction enhancesrosuvastatin-inducedeffecton LDLcho/estero/, LOX-1expressionand ProteinKinaseBphosphorylation inpatientswithhyper/ipidemia. /nternationa/JournalofCardiology Dec2013, 170(2):140-5.https://doi.org/10.1016/j.ijcard.2013.08.125

6. ZX.Su ZR. Curcumin's Metabolites. Tetrahydrocurcumin and Octahydrocurcumin. PossessSuperiorAnti-inflammatory EffectsinvivoThrough SuppressionofTAKI-NF-KBPathway.FrontPharmaco/.2018Oct17;9:1181.https://doi:10.3389/fphar.2018.01181.

7. Ishida, Y.; Sagitani.A.; Kaneko. K.;Nakamura. Y.; Mizutani.J.; Masuda, O.;Watanabe, M.;Sato.S.;Shioya. N. Antihypertensive effectsofthetab/et containing "/actotripeptide (IPP, VPP)"insubjectswithhigh normal bloodpressureormild hypertension.J. Pharmaco/. Ther. 2007, 35, 1249-1260 doi:10.3390/nu7010659

INGREDIENTS

MITOaU"N]®

MitoBurn® (8-aminoisobuytric acid, L-BAIBA) knownforactivation ofBATviathesamegeneticinfluenceasbittermelon extractandalsoforenergyexpenditure. Itaccomplishes this byactivatingthe peroxisome proliferator-activatedreceptor gamma coactivator 1-alpha (PGC-la).atranscriptionalcoactivatorthatplays akeyrolein regulatingenergymetabolismand mitochondrial biogenesis.1 This activation occurs bywayofAMPK.oneofthe varioussignalingpathways thatregulate the shiftfromwhitetobrownadipose tissue.

Factor21® Bitter Melon Extract (Momordica charantia). isderivedfrombittermelon's effect onahormone called Fibroblastgrowth factor 21 (FGF21). Specifically. bittermelon extract hasbeenshownto activate thenuclearreceptor peroxisomeproliferator-activatedreceptoralpha (PPARa). whichinturn leadstotheactivation ofFGF21.Benefitsofthis activationincludesupportinginsulinsensitivityandglucosetolerance. Ithasalsobeenshowntosupportinsulinsensitivity byincreasingglucose uptakeand utilizationin cells. ThisisaccomplishedbyactivatingAMP-activated proteinkinase (AMPK)aswellasbyincreasingthetranslocationofglucose transporter4 (GLUT4) to thecellmembrane.GLUT4is responsiblefortransportingglucosefrom thebloodinto cells.andincreasingitstranslocationto the cellmembrane.2 3

GLUCO 'VANTAGE®

GlucoVantage® (Dihydroberberine). a chemical analog of berberine. has also been shown to support healthy insulin sensitivity levels by activating AMPK and supporting glucose uptake and utilization in muscle cells. Dihydroberberine is a new version of traditional berberine that is up to Sx more bioavailable/absorbable and 2x longer lasting (8 hours vs. 4 hours).5 It can also help with advanced glycation end products correlated with aging while supporting blood glucose disposal and improving insulin sensitivity and body composition. Plus, berberine in itself holds potential in supporting metabolism via its effect on the microbiota.6

ln:!!!Slim

lnnoSlim® . a combination ofAstragalus membranaceus andPanaxnotoginseng, has alsobeen shown to activateAMPK as well as increase the level of a key hormone called adiponectin, which is linked to higher levels of insulin sensitivity and supporting healthy glucose metabolism.7Additionally, it was found that lnnoSlim® reduces glucose absorption in the intestineby 42% by downregulatingtheSGLTl transporterandincreasesglucoseabsorptionin muscle and fatcellsby 50% and 68% by up regulating GLUT4transporter.8 9

Actiponin®

Actiponin® . activates theAMP-activated protein kinase (AMPK). an important intracellular sensorand regulator of glucose metabolism. lipid metabolism. and energy metabolism throughout the body. When activated, this powerful enzyme switches on catabolic ATP-generating pathways like fatty acid 13-oxidation. glycolysis. and glucose uptake (processes that normally occur during intensive exercise or prolonged starvation) and switches off anabolic ATP-consuming pathways like fatty acid and cholesterol synthesis.10

CALORlaU"N;)®

CaloriBurn GP® , agrains of paradise extract containing 6-paradol, has been shown to activateBAT and promote thermogenesis, leading to increased energy expenditure and imp roved metabolic health.11 Brown adipose tissue (BAT) is a specialized type of fat tissue that is involved in thermogenesis. or the generation ofheat. leading to increased energy expenditure and improved glucose and lipid metabolism.

CoQ10

Cellular Energy Production*

MicroActive® CoQlO is an advanced formulation of CoenzymeQlO (CoQlO) with unmatched absorption and superior bioavailability. This innovative 24-hour sustainedrelease MicroActive® CoQlO hasuniformlyenhanced bioavailability. making it 3x more absorbed than regular (crystalline) CoQlO and 2x more absorbablethansolubilized (enhanced bioavailability) CoQlOsoftgels.1 This meansit ismorereadily availabletothe body'stissuesand organs. ensuring efficient utilization and playingacrucial role in energy production and serving asapotent antioxidant. protectingcellsfrom oxidativedamage and providing cellular energy supportto themost vital organs including the heart and brain.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN

Supports CardiovascularHealth

PATIENTS REQUIRING

• Powerful Antioxidant Support

• Restoration of Energy Stores

• Mitigation of Deleterious Nature of Statin Medications

• Cardiovascular and/or Neurological Support

• Protocolsto Assist Athletes & Physically Active Individuals

AidsAntioxidant Activity Promotes NeurologicalHealth

MaintainsHealthy Bloodsugar Balance

SupportsCellularEnergy Production & PhysicalPerformance

MicroActive® CoQlO is aregistered trademarkofBioactives LLC CoQlO Cellular Energy Production' DietarySupplement 60 Capsules

DIRECTIONS:

Take 1 capsule daily or asdirected by yourhealthcarepractitioner.

SUPPLEMENT FACTS

Serving Size: 1 Capsule Servings Per Container: 60

CoenzymeQlO (fromMicroActive• QlO-cyclodextrincomplexandCoQ10)

•DailyValue NotEstablished

AmountPerServing %DY 120mg *

Other Ingredients: Vegetable Capsule (Hypromellose). Rice Powder, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

DEFEND

Foundational Combination of Vitamins A, D, and K2*

Vitamins A, D, and K2 are essential nutrients that play important roles in various biological processes. Vitamin A is vital for vision, immune function, and cellular growth and differentiation. Vitamin Dis essential for bone health, and immune function, and has been linked to numerous other health benefits. Vitamin K2 is necessary to supportbone health and cardiovascular health. Since these three nutrientswork together and depend on one another, their combination ina dietary supplement is key. AstraGin® , a proprietary blend of Astragalus membranaceus and Panax notoginsengextracts, serves to improve nutrient absorptionand enhance thebioavailability ofcertain compounds, these vitamins included. When combined these nutrients and AstraGin® can create a synergistic effect, potentiallyenhancing theirbenefits and improving overall health.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN PATIENTS REQUIRING

BENEFITS

• Cardiometabolic Support

• Bone Building & Strengthening Aid

• Immune System Support

• Sex Hormone Metabolism Support

Supports Healthy Calcium Deposition in Bones & Teeth

Supports Healthy Levels of Oxidation within Blood Vessels

Promotes Broad Immune System Activation

Aids in the Metabolism of Lipids

DIRECTIONS:

Take 1 capsule daily or as directed by your healthcare practitioner.

DEFEND

SUPPLEMENT FACTS

Serving Size: 1 Capsule Servings Per Container:

(asretinylpalmitate)(S,000

D(asVitaminD3,cholecalciferol)(S,000IU) 125mcg 625%

VitaminE(asd-alphatocopherolsuccinate)(121IU) 100mg 667%

VitaminK2MK-7(asK2VITAL•DELTA 200mcg * AII-TransMenaquinone-7)

AstraGin" (Astragalusmembranaceus and Panaxnotoginseng) RootExtracts

•DailyValueNot Established 50mg

Other Ingredients: Nuflow, VegetableCapsule (Hypromellose)

DEFEND PRO

SUPPLEMENT FACTS

Serving Size: 1 Capsule I Servings Per Container: 60

VitaminA(asretinylpalmitate)(S,000IU) 1515mcg 168%

VitaminD(asVitaminD3,cholecalcifero1)(10,000IU) 250mcg 1250%

VitaminE(asd-alphatocopherolsuccinate)(121IU) 100mg 667%

VitaminK2MK-7(asK2VITAL•DELTA 300mcg * All-TransMenaquinone-7)

AstraGin" (Astraga/usmembranaceus and Panaxnotoginseng) Root Extracts

50mg

•DailyValue Not Established

Other Ingredients: Nuflow, Vegetable Capsule (Hypromellose)

SEX HORMONE METABOLISM

Vitamins A and D are both involved in the regulation of sex hormone metabolism. Vitamin Ais vital for producing sex hormones, while vitamin Dis crucial in regulating sex hormone levels.

Retinoic acid. a derivative of vitamin A. is involved in the synthesis of sex hormones such as testosterone and estradiol. Retinoic acid regulates the activity of the enzymes that convert cholesterol into sex hormones. In particular. it supports theactivity of the enzyme CYP17Al. which synthesizes androgens such as testosterone. Italso regulates the activity of the enzyme CYP19A1, which synthesizes estrogens such as estradiol.

Vitamin Dis also involved in the regulation of sex hormone levels. Itacts on the hypothalamus and pituitary gland to regulatethe production of luteinizinghormone (LH)and follicle-stimulatinghormone(FSH).essentialforproducingsex hormones.Vitamin Ddeficiencyhasbeenassociatedwithlowlevelsoftestosteroneandhighlevelsofsexhormonebinding globulin (SHBG), which can lead to reduced bioavailability of testosterone.

BOOST ABSORPTION

AstraGin® is a proprietary blend of Astragalus membranaceus and Panax notoginseng extracts that have been shown to have several potential health benefits. While the effects of AstraGin® specificallyon heart health and immune health have not been extensively studied. the individual components ofAstraGin® have shown potential benefits for the cardiovascular system through antioxidant support. vessel relaxation. and lipid metabolism. But perhaps more importantly. AstraGin® has been shown toimprove nutrient absorption and enhance the bioavailabilityof specific compounds. One prime example of this is the increase in the expressionof the glucose transporter GLUT4, which is involved in the transport of vitamin K2 as well as other nutrients across the intestinal lining.

Allinall. Defend and Defend Pro. featuringvitaminsA. D. and K2. along withAstragin.offersauniquecombinationofnutrients that synergistically support heart. bone, immune. and hormone health. improving nutrient absorption and utilization for overall wellness.

REFERENCES

1. ZalaketJ,Hanna-Wakiml,MattaJ.AssociationbetweenHDL Cholesterol levels andtheConsumptionofVitaminAinMetabolically HealthyObese Lebanese:ACross-Sectional StudyamongAdultsinLebanon. Cholesterol.2018Jun 3;2018:8050512.doi: 10.1155/2018/8050512. PMID: 29971161; PMCID:PMC6008699.

2. Maresz K. Proper Calcium Use:Vitamin K2asaPromoterofBoneand Cardiovascular Health. lntegrMed (Encinitas). 2015 Feb;14(1):34-9.

3. Dupuis,M.L,Pagano,M.T.,Pierdominici,M.etal.TheroleofvitaminDinautoimmunediseases:couldsexmakethedifference?.BiolSexDiffer12, 12(2021).

4. MartensPJ,GysemansC,VerstuyfA, MathieuAC. Vitamin D's EffectonImmune Function. Nutrients.2020Apr 28;12(5):1248. SHOP@INFINIWELL.COM 888-819-4640 WWW.INFINIWELL.COM *These statements have not been evaluated by The Foodand Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

THE ART OF HORMONE BALANCING

One of DHEA's most intricate roles in physiology is its ability to serve as the metabolic precursor to both estrogen and testosterone, two hormones that sculpt the contours of human health. With a delicate touch, DHEA ensures that the seesaw of these hormones remains in perfect equilibrium, alleviating the symptoms that often arise from hormonal imbalances. Symptoms such as mood swings, fatigue, and waning libido can be signs of a diminished DHEA presence.1 In the realm of the endocrine system, cortisol reigns as the chief orchestrator of the body's stress response. However, when cortisol surges unchecked, it can provoke havoc on our health, from immunosuppression to metabolic disharmony. DHEA steps in as the counterbalance, ensuring that cortisol is operating within a beneficial range, thereby mitigating the insidious effects of chronic stress.2

Beyond hormonal harmony, DHEA's impact extends to the intricate realm of the nervous system. It can serve as a neuroprotector. encouraging the growth and maintenance of neurons through the production of neurotrophic factors. Such an endeavor is not merely artistic; it is critical in the realm of conditions such as mood, cognitive health, and neurological function.3

MECHANISMS OF ACTION

Steroidogenesis

DHEA is a multifaceted molecule, capable of transformationwithintargettissues. It metamorphoses intoactivesex hormones, including estrogen and testosterone. precisely when the body requires them. This ability to adapt and fine-tune hormonal levels makes DHEA a vital component to true hormonal balance.•

Healthy Inflammation Support

The stage on which DHEA performs its support for the body's natural inflammatory response focuses heavily on cytoki nes and oxidative stress. With incredible precision, it modulates cytokine production and mitigates oxidative stress. ultimately contributing to overall health.5

Receptor Support

DHEA also operates extensively at the molecular level, where it elegantly interacts with and activates specific receptors. such as the androgen and estrogen receptors. This interaction influences gene expression and cellular responses, ensuring that the body's responses are as harmonious as possible.6

5 MG OR 25 MG: WHICH IS MOST APPROPRIATE?

It is a best practice to test DHEA levels in order to determine which amount is needed for any particular patient. In general, while these dosages of DHEA can not always recommended for these particular indications. it may serve as a helpful guide to see which product might be appropriate for your patient.

Indications for 5 mg DHEA

• Aging and longevity support

• Mood and emotional support

• General hormone balance support

Indications for 25 mg DHEA

• Bone density support

• Adrenal insufficiency

• Libido support

DHH-8

Mood Support*

Dihydrohonokiol-B (DHH-B) is a natural compound derived from the root bark of Magnoliaofficinalis, a traditional Chinesemedicinalplant. It has garnered considerable attention inrecentyearsdue to its potentialtherapeutic properties. having 20x the strength of standard magnolia extract. DHH-B promotes a sense of tranquility and calmness. By targeting key neurotransmitters. this remarkable compound helps alleviate stress and supports relaxation. Its unique mechanism of action encourages a balanced state of mind. allowing you to navigate daily challenges with ease. Additionally. DHH-B promotes healthy sleep patterns. allowing individuals who take it to achieve restful nights and wake up feeling refreshed and rejuvenated.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN

BENEFITS

DHH-8

MAX

Support' DietarySupplement 30Capsules

Promotes an Overall Sense of Calm PATIENTS REQUIRING

• Stress & Sleep Protocols

• Mood & Neurological Protocols

• Inflammation Support

Maintains Healthy Neurotransmitter Release (Specifically, GABA)

Helps Promote Relaxation & Reduced Nervousness

�GLUTEN � SOY iWFREE �FREE

DIRECTIONS: a ({')/J.. DAIRY � NON �)FREE �GMO

Take 1 capsuleasneededorasdirected byyourhealthcare practitioner.

SHOULD NOT BE TAKENWITH ALCOHOL

DHH-8

SUPPLEMENT FACTS

Serving Size: 1 Capsule Servings Per Container: 30

DHH-B (Dihydrohonokio/-8) (derived from magnolia bark)

•DailyValueNotEstablished

AmountPerServing %DV 7.5mg

Other Ingredients:Cellulose. RicePowder,Hydroxypropyl Methylcellulose, Magnesium Stearate, Silicon Dioxide, Vegetable Capsule (Hypromellose)

Promotes Both Healthy REM & Non-REM Sleep Cycles

DHH-8 MAX

SUPPLEMENT FACTS

Serving Size: 1 Capsule I Servings Per Container: 30

DHH-B (Dihydrohonokio/-8) (derived from magnolia bark)

*DailyValueNotEstablished

AmountPerServing %DV 15mg

OtherIngredients:Cellulose.Rice Powder,Hydroxypropyl Methylcellulose. Magnesium Stearate. Silicon Dioxide, Vegetable Capsule (Hypromellose)

DIM

Hormone Support & Detoxification*

In the realm of natural compounds. one has steadily risen to prominence for its potential to enhance overall health and maintain equilibrium in various bodilysystems. Diindolylmethane (DIM) is a bioactive substance sourced from cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. Scientific research has illuminated DIM's remarkable contributionsto well-being. with its primary areas of applicationsfocusing sfunctionand cellular health.

DEMOGRAPHIC & CLINICAL

APPLICATIONS

MEN & WOMEN PATIENTS REQUIRING

BENEFITS

• Hormonal Balance Protocols

• Estrogen Dominance Support

• Phase II Detoxification Support

• Immune SystemMaintenance

Supports Healthy Estrogen Metabolism

Promotes Leaner Body Composition

Aids Liver Detoxification

Supports Antioxidant Capacity

Diindolylmethone

HormoneSupport& Detoxification'

DietarySupplement 60Capsules

DIRECTIONS:

Take 2 capsules with water daily or as directed by your healthcare practitioner.

SUPPLEMENT FACTS

Serving Size: 2 Capsules Servings Per Container: 30 AmountPerServing %DV

DIM(Diindolylmethane) 150mg

*DailyValueNotEstablished

Other Ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide,Vegetable Capsule (Hypromellose)

KEY FUNCTIONS

Balancing Hormones

DIM's first major feat lies in hormonal equilibrium. It engages in a crucial role by aiding in the metabolism of estrogen.a hormone that wields significant influence over health. Through a series of metabolic transformations.DIM encourages the conversion of potent forms of estrogen.like estradiol (E2).into less active metabolites such as 2-hydroxyestrone (2-0HEl). This process holds the potential to reduce the risk of health concerns related to estrogen dominance.'

Supporting Detoxification

The body'sdetoxificationpathways formthe frontline of defenseagainst harmfultoxins andcarcinogens. DIM steps into this arenabyfortifyingphase II detoxification pathways.Itpromotesthe expression and activityofcritical detoxifying enzymes.includingcytochrome P450, glutathione S-transferases, andquinone reductase. In doing so, itfacilitates the elimination of harmfulcompounds.enhancing thebody's detoxificationcapabilities.2 3

Nurturing theImmune System

DIM's reachextendsto the immune system.a vital guardian of health. Itmodulates immune responses byinfluencingthe production and activity ofimmunecells.includingT lymphocytes and naturalkilier (NK)cells.Theresult is a more robust and balanced immune system.readyto fend off threats and maintain well-being. 4 5

Guarding CellularHealth

Amidthe bustling landscapeofourbodies.cellular health stands paramount. DIM donsthecape of a potentantioxidant. swooping in to shield cells from oxidative stress andthe perils offree radical damage.This guardianofcells bolsters the body's innate defenses against oxidative harm.combatingthe agingprocess and potentially loweringthe riskof oxidative stress-related diseases.67

REFERENCES

1. Bradlow, H.L, etal. (1991). Long-term responsesofwomentoindole-3-carbinolorahighfiberdiet.Cancer Epidemiology, Biomarkers & Prevention, 1(5), 345-351.

2. Reed, G.A,etal. (2005). AphaseIstudyofindole-3-carbinolinwomen:tolerabilityandeffects.CancerEpidemiology,Biomarkers&Prevention, 14(8),1953-1960.

3. Lord, R. S.,etal. (1997). Urinarymetabolitesofindole-3-carbinolinhumansandrats.ChemicalResearchinToxicology, 10(12), 1228-1233.

4. Ge,X.,etal. (2013). lndole-3-carbinolinhibits LPS-inducedinflammatoryresponseby blocking TRIF-dependentsignalingpathway inmacrophages. FoodandChemicalToxicology,53,56-64.

5. Kim, Y. H.,etal. (2019). Diindolylmethanesuppressesthegrowthof5-fluorouracil-resistantcolorectalcancercellsthroughtheactivationofthep38 MAPKpathway. Oncology Letters, 18(3), 2577-2586.

6. Rahman, K.M., etal. (2008). Dietaryindolessuppressdelayed-type hypersensitivity byinducinga switch fromproinflammatory Th17 cells to anti-inflammatoryregulatory T cells through regulationofmicroRNA Journal ofImmunology, 180(1), 659-669.

7. AI-Malki, AL, & El Rabey, H.A(2015). The antidiabeticeffectoflowdosesofMoringaoleifera Lam. seedsonstreptozotocininduceddiabetesand diabetic nephropathyinmale rats.BioMedResearchInternational, 2015, 381040.

DNA PRIME

Unparalleled Cellular Protection & Telomere Support*

Telomeres. DNA. andmitochondriaareessentialcomponentsofourcells andplay crucialroles incellularfunctionandoverallhealth.Telomeres are theprotective capsattheendsofourchromosomesthatpreventthelossofgeneticinformation during cell division. Over time. telomeres naturally shorten. which can lead to cellular aging and increased risk of age-related diseases. DNA is the genetic materialthatprovides theinstructionsforcellularfunction. whilemitochondria are the powerhouses of the cell. responsible for producing energy. Damage to DNA and mitochondria can lead to cellular dysfunction and increased risk of diseasessuchascancer.neurodegenerativediseases.andcardiovasculardisease.

Overall. maintaining the health of our telomeres. DNA. and mitochondria is essentialfor healthy aging andlongevity. Aswe age. these cellular components naturally decline. makingitimportant to supportthemthrough various means. including diet. exercise. and targeted nutritional supplementation. The use of supplements containing ac-11® Cat's Claw Aqueous Extract. Activated BroccoRaphanin® . Sulforaphane Glucosinolate. BuckwheatPeptides. 2-HOBA. and MitoPrime® (L-ergothioneine) serveasapromisingwaytosupportthehealth of our telomeres. DNA. and mitochondria. and promote healthy aging overall.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN&WOMEN PATIENTSREQUIRING

BENEFITS

Cellular Protection &

Telomere Support'

DietarySupplement 60Capsules

• Healthy Aging & Longevity

• Healthy Cardiometabolic Function

• Healthy Neurological Function

• Mitochondrial Support

Supports Telomere Length & Telomerase activity

Supports DNA Repair & Cellular Renewal

Promotes Mitochondrial Function

Aids in the Mitigation of Oxidative Stress

DIRECTIONS:

Take 2 capsuleswith water daily or as directed byyourhealthcarepractitioner.

SUPPLEMENT FACTS

Serving Size: 2 Capsules I Servings Per Container: 30 AmountPerServing %DV

ac-11 ® Cat'sClawAqueousExtract 700mg * (Uncariatamentosa) (bark)(standardizedto8% carboxyalkylesters,CAEs)

ActivatedBroccoRaphanin•(Broccoli 300mg concentratefromseedandmyrosinaseenzyme)

SulforaphaneGlucosinolate 30mg (asGlucoraphanin)

BuckwheatPeptides20:1 200mg

2-HOBA(Hobamine®) 100mg

L-Ergothioneine(asMitoPrime®) 10mg

*DailyValueNotEstablished

OtherIngredients: Microcrystalline Cellulose, MagnesiumStearate (Vegetable),Silica,Vegetable Capsule (Hypromellose)

REFERENCES

I. Akesson, Christina et al. "An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity withoutinducing cell death. "International immunopharmacology 3,13-14 (2003): 1889-900. doi:10.1016/j.intimp.2003.07.001

2. Sheng, Yet al. "Enhanced DNA repair, immunefunction and reduced toxicityofC-MED-100,a novel aqueous extract from Uncaria tomentosa. "Journal of ethnopharmacology 69,2 (2000): 115-26. doi:JO.l016/s0378-874l(99)00070-7

3. Vanduchova, Alena et al. "lsothiocyanate from Broccoli, Sulforaphane, and Its Properties."Journal of medicinal food 22,2 (2019): 121-126. doi:J0.1089/jmf.2018.0024

4. Houghton, Christine A. "Sulforaphane: Its "Comingof Age" as a Clinically Relevant Nutraceutical inthe Prevention and Treatment of Chronic Disease."Oxidativemedicine and cellular longevity 20192716870. 14 Oct.2019,doi:10.1155/2019/2716870

5. Zhou,X., Wen, L, Li,Z.et al. Advance onthebenefitsofbioactive peptides from buckwheat. PhytochemRev 14, 381-388 (2015). https://doi.org/10.1007IslllOl-014-9390-0

6. Davies SS, May-Zhang LS, Boutaud 0, Amarnath V, Kirabo A. Harrison DG. lsolevuglandins as mediators ofdiseaseand the development of dicarbonylscavengers as pharmaceutical interventions. Pharmacol Ther. 2020;205:107418. doi:10.1016/j.pharmthera.2019.107418

7. Davies SS, Zhang LS.Reactive Carbonyl Species Scavengers-Novel Therapeutic Approaches for Chronic Diseases. Curr Pharmacol Rep. 2017;3(2):51-67. doi:JO.l007/s40495-0l7-008l-6

8. Mayorov V, Uchakin P, Amarnath V, et al. Targeting of reactive isolevuglandins in mitochondrial dysfunctionandinflammation.Redox Biol. 2019;26:101300. doi:10.1016/j.redox.2019.101300

9. McMaster WG, Kirabo A, Madhur MS, Harrison DG.Inflammation, immunity,and hypertensive end-organ damage. Gire Res. 2015;116(6):1022-1033. doi:10.1161/CIRCRESAHA.116.303697

10. Samuel P, TsapekosM,de Pedro N, Liu AG, Casey LippmeierJ, Chen S. Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions.JDiet Suppl. 2022;19(2):212-225.doi:l0.l080/J93902ll.2020.l8549l9.Epub 2020 Dec 7. PM/D: 33287595.

II. Fu TT, Shen L Ergothioneine as a Natural AntioxidantAgainst Oxidative Stress-Related Diseases.Front Pharmacol. 2022 Mar 18;13:850813. doi: 10.3389/fphar.2022.850813. PMID: 35370675; PMC/D: PMC8971627.

INGREDIENTS

Arginine Alpha-Ketoglutarate

Arginine Alpha-Ketoglutarate (AAKG) is a vital molecule in the tricarboxylic acid (TCA) cycle. a central pathway for energy production in cells, and is critical in cellularenergymetabolism and functions such as DNA and proteinsynthesis. AAKG acts as a precursor to nitric oxide (NO). a signaling molecule involved in various cellular processes. By supporting nitric oxide production. AAKG promotes blood flow and oxygen delivery to tissues. optimizing mitochondrial function. Furthermore. AAKG exhibits potent antioxidant properties. reducingoxidative stress and preserving mitochondrial integrity.The combinedeffects of AAKG on nitricoxide production. blood flow. oxygendelivery. and antioxidation contribute to its ability to promote longevity.1-2

Trimethylglycine

Trimethylglycine (TMG), also known as betaine anhydrous. is a naturally occurring compound with diverse physiological functions. TMG acts as a methyl donor. supporting DNA and histone methylation. which play critical roles in gene expression regulation and maintaining cellular function. By modulating gene expression, TMG helps optimize cellular function and contributes to its longevity-promotingeffects.3-•

E GAM NTE.

Natural polyphenols found in fruits. vegetables. and tea exhibit potential in the prevention and treatment of cancer through various mechanismsof action. These include antioxidant activity. modulation of cell signaling pathways. DNA methylation. and apoptosis. Bergamote® (bergamot orange extract). rich in polyphenols such as flavonoids and citrus bergamia polyphenols (CBPs). offers multiple mechanisms of action that promote longevity. Its potent antioxidant properties neutralize reactive oxygen species (ROS) and reduce oxidative stress. It has been shown to support cardiovascular health and support healthy cholesterol, blood sugar levels and weight loss.5•6•7 Additionally. bergamot orange extract supports endothelial function. promoting blood flow and cardiovascular health.8 9

Epigallocatechin Gallate

Epigallocatechin gallate (EGCG). a polyphenol found in green tea. promotes longevity through various mechanisms. EGCG scavenges free radicals. reduces oxidative stress. and protects cellular components as a potent antioxidant. Furthermore. EGCG supports autophagy. a cellular process that clears damaged proteins and organelles. promotes cellular function and support longevity.10 11

Taxifolin

Bioactivecompounds.includingpolyphenolsand flavonoids. possess the ability to support a healthy inflammatory response. including the NF-KB pathway and cytokine production. Taxifolin, also known as dihydroquercetin. is a flavonoid found in various plant sources that exhibits diverse mechanisms of action contributing to its longevity-promoting effects. It acts as a potent antioxidant. effectively scavenging free radicals and reducing oxidative stress. which can lead to cellular damage and aging. Additionally. taxifolin enhances mitochondrial biogenesis and supports electron transport chain activity. resulting in energy production and cellular respiration.12 13

Spermidine

Spermidine is a polyamine naturally present in various foods and cells. It plays a crucial role in cellular processes such as autophagy and gene expression regulation. Spermidine promotes autophagy. which removes damaged cellular components and supports cellular rejuvenation. By supporting autophagy. spermidine helps maintain cellular health. It also exhibits antioxidant properties. protecting cells from oxidative damage. Furthermore. spermidine regulates gene expression by interacting with chromatin and influencing histone modifications. contributing to cellular homeostasis and longevity.14 15

EPICATECHIN

Cardiovascular Support & Muscle Function*

Epicatechin, a flavanol compound found in sources like cocoa, green tea, and berries, offers a range of potential health benefits. With its antioxidant properties, epicatechinneutralizesharmful free radicals and supports cellular health. It stimulates the production of nitric oxide, promoting improved blood flow and cardiovascular health. Epicatechin also enhances insulin sensitivity, positively impacting glucose metabolism and reducing the risk of insulin resistance. Perhaps most notably, epicatechin aids muscle growth through myostatin inhibition, increased nitric oxide production, and enhanced protein synthesis. By harnessing these mechanisms, epicatechin may support overall cognitive function, metabolic health, and muscle performance and recovery.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN PATIENTS REQUIRING

BENEFITS

• Workout Endurance & Stamina Support

• Muscle Recovery Support

• Exercise-Related Muscle Soreness Aid

• Lean Muscle Mass Maintenance Support

EPICATECHIN

Cardiovascular Support & Muscle Function'

DietarySupplement 60Capsules

Strength Stamina & Nitric Oxide Gains Endurance Support

DIRECTIONS:

Take 2 capsules daily or as directed by your healthcare practitioner.

SUPPLEMENT FACTS

Serving Size: 2 Capsules I Servings Per Container: 30

AmountPerServing %DV

Epicatechin 500mg

•DailyValue Not Established

Other Ingredients: Magnesium Stearate, Silicon Dioxide,VegetableCapsule (Hypromellose)

FOCUS

Breakthrough Nootropic For Everyone*

A highly-functioning brain is essential for overall well-being and quality of life. Itenablescritical thinking.problem-solving.learning.anddailyfunctioning. Additionally.a healthy brain is crucial for maintaining memory.focus, and cognitive abilities as we age. Natural compounds can play a significant role in supporting brain function by offeringcognitive properties.including antioxidant and neuroprotective effects. Focus is a scientifically formulated cognitive support formula that combines RhodioPrime® 6X Rhodiola. LuteMax2020. lnnovaTea® naturalcaffeine. Dynamine™ . TeaCrine® . and HuperzineA These ingredients work synergistically to support mental performance.promote focus and memory.and sustain mental energy.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN PATIENTS REQUIRING

BENEFITS

• Neurological & Memory Protocols

• Sustained Mental Energy & Alertness

• Daily Blue Light Protection

• Eye Strain & Fatigue Support

Complete Nootropic'

Supplement 30 Capsules

Optimized Neurological Processing and Function

SustainedMental Acuityand Recall

& LongTermBrain/ Working MemorySupport

DIRECTIONS:

Take 1 capsule in the morning with water or as directed byyour healthcare practitioner.

SUPPLEMENT FACTS

Serving Size: 1 Capsule Servings Per Container: 30 Amount Per Serving

RhodioPrime•6X Rhodiola Extract 250mg * (std to 6% Salidroside) LuteMax2020 200mg * (20mg Lutein, 4 mg Zeaxanthin) InnovaTea• NaturalCaffeine98% 150mg * (from Tea) - Camellia sinensis Methylliberine (as Dynamine™) 100mg * Theacrine(as TeaCrine•) 100mg * HuperzineA [from (toothed clubmoss) 200mcg * extract (whole herb)]

• Daily Value Not Established

Other Ingredients: Vegetable Capsule (Hypromellose, Gellan Gum), Rice Powder. Microcrystalline Cellulose

NEUROPLASTICITY AND COGNITIVE FUNCTION

Neuroplasticity refers to the brain's ability to adapt, change, and reorganize itself in response to experiences, learning, and environmental factors. It underlies cognitive function and plays a vital role in learning, memory, adaptability, recovery from brain injuries, and maintaining brain health. The following areas highlight the importance of neuroplasticity:

Learning and Memory

Neuroplasticity allows for acquiringknowledge, learning new skills, and forming memories bystrengtheningand modifying synaptic connections between neurons.

Adaptability and Flexibility

Neuroplasticity enables the brain to adapt to changing circumstances and environmental demands, enhancing cognitive strategies, problem-solving approaches, and behavioral responses to novel situations.

Recovery and Rehabilitation

Neuroplasticity is crucial in brain injury or neurological disorders. allowing the brain to reorganize and reroute functions to undamaged areas, facilitating recovery and rehabilitation.

Lifelong Learning and Brain Health

Engaging in continuous learning, mental stimulation, and novel experiences promotes neuroplasticity, maintaining and enhancing neural connections for better cognitive function and reducing the risk of age-related cognitive decline.

Cognitive Reserve

Neuroplasticity contributes to cognitive reserve, which helps maintain optimal cognitive function despite age-related changes or brain pathology. Individuals with higher cognitive reserve exhibit better cognitive performance and resilience to neuro-decline.

INGREDIENTS SUPPORTING NEUROPLASTICITY

Among the ingredients in Focus. RhodioPrime® GX Rhodiola, LuteMax2020, and Huperzine A have shown potential benefits for supporting neuroplasticity.

• RhodioPrime® modulates neurotransmitters and neurotrophic factors involved in neuronal growth and synaptic plasticity. It may promote the release of brain-derived neurotrophic factor (BDNF). a protein that plays a key role in promoting neuroplasticity and neuronal survival.

• LuteMax2020 supports healthy levels of oxidative stress and inflammation. thereby promoting neuroplasticity.

• Huperzine Aincreases the concentration of acetylcholine, a neurotransmitter crucial for learning,memory,and neuroplasticity.

GI PRIME

Comprehensive Pre/Pro/Post

Biotic Formula*

GI Prime is a dietary supplement formulated to support gut health and promote overall digestive well-being. This advanced blend combines the following ingredients known for their beneficial effects on gut microbiota and immunefunction: Epicor®, which hasbeenshown tosupportgut health by promotinga balancedgutmicrobiota, modulatingimmune function, and improvinggutbarrierintegrity. lMMUSE™ .acutting-edgepostbioticclinically shown toactivate your body'snatural defensesat the cellular level toprovide comprehensivegut and immune support year-round. Butyragen™ servesas a butyrate-producing innovation andfinallya combination of Bacillus coagulans, subtilis, and clausii.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN

BENEFITS

Supportsa Healthy GutMicrobiota

PATIENTS REQUIRING

• Overall Digestive Support

• Acute & Ongoing Immune System Support

• Gut Dysbiosis Assistance

• Gut Permeability Protocols

GI PRIME

Pre/Pro/Postbiotic & ButyrateGenerator' Dietary Supplement 90 Capsules

Strengthens ImmuneSystem AidsinOptimizing Gut Barrier Integrity

Modulates Immune ResponseintheGutvia ActivationofpDC's, Supports Digestive Function & Regularity

DIRECTIONS:

Take 3 capsuleswithwaterdailyoras directed byyour healthcare practitioner.

SUPPLEMENT FACTS

Serving Size: 3 Capsules I Servings Per Container: 30 Amount Per Serving

Dried Yeast Fermentate (EpiCor•) 500mg (Saccharomycescerevisiae)

Lactococcus lactis strain Plasma 50mg (IMMUSE™ Postbiotic)

ButyraGen™ 200mg

Spore Probiotic Blend 12billion CFU

Bacillus Coagulans (SNZ1%9)

Bacillus Subtillus (SNZ1972)

Bacillus Clausii (SNZ1971)

•DailyValue Not Established

Other Ingredients: Rice Powder, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Vegetable Capsule (Hypromellose)

Bacillus Strains of Probiotics

Theprobiotic strainsBacilluscoagulans,Bacillussubtilis, andBacillusclausii, found in GI Prime, canpotentiallyinfluence the gut-brain axis. The gut-brain axis refers to the bidirectional communicationpathway between the gut and the brain, involving thenervous, endocrine, and immunesystems.

Probiotics have been shown to influence the gut-brain axis through severalmechanisms:

Production of Neurotransmitters: Certainstrains ofprobiotics,includingBacillusspecies, havethecapability toproduce neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA). These neurotransmitters play a crucial role in mood regulation, cognitive function, and overall mental welI-being.By producing these neurotransmitters, probiotics can indirectly influence the gut-brain axis and potentially impact mental health.

Healthy Expression of Inflammation: Probioticshave beenshowntosupporthealthylevels of inflammation in the body, including withinthenervoussystem.By supporting this healthyexpression, probiotics, includingBacillusstrains, canhelp modulate excessiveneuronal stress andstrengthenthe gut-brainaxis.

Regulation of Stress Response: The gut-brain axis is closely involved in regulating the body's response to stress.

Probiotics, including Bacillus strains, have been found to modulate the stress response through interactions with the hypothalamic-pituitary-adrenal (HPA) axis and the release of stress-related hormones. By influencing stress pathways, probiotics can indirectly impact the gut-brain axis and potentially improve stress-relatedmental health outcomes.

REFERENCES

1.Pinheiro, I., et al .Ayeast fermentate improves gastrointestinal discomfort andconstipation by modulation ofthegut microbiome: results from a randomized double-blind placebo-controlled pilot trial. BMC Complement Altern Med2017,17 (1), 441.

2. Oucray, H.A.G.,et al. Yeast fermentate prebiotic improves intestinal barrierintegrityduringheatstress by modulation ofthegut microbiota inrats. J Appl Microbiol2019,127,1192-1206.

3. Sugimura T, TakahashiH,JounaiK,0hshioK, Kanayama M, Tazumi K,Tanihata Y, Miura Y, Fujiwara 0, Yamamoto N. (2015)Effectsof oral intakeof plasmacytoid dendritic cells-stimulative lactic acid bacterial strainonpathogenesisof influenza-like illness and immunological responseto influenza virus.Br J Nutr. 3:1-7.

4.SuzukiH,OhshioK,Fujiwara 0. (2016)Lactococcus lactis subsp. lactis JCM5805activates natural killer cells viadendritic cells. BiosciBiotec Biochem. 80: 798-800.

5Rios-Covian 0, Ruas-MadiedoP,MargoliesA, Gueimonde M, de los Reyes-Gavilan CG,SalazarN. Intestinal shortchainfattyacidsandtheir link withdietand human health. FrontMicrobiol2016;7:9.

6.GaoZG, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye JP. Butyrate improves insulin sensitivityandincreasesenergyexpenditurein mice. Diabetes2009;58:1509-17.

IGNIGHT

The Key to Optimal Sleep & Metabolic Health*

In the chaos of modern life, finding a peaceful night's sleep can be elusive. Stress. anxiety, and the challenges of maintaining a healthy metabolism often stand in the way of the restorative slumber we all crave and need for optimal health. lgNIGHT. a leader in restorative sleep support, is a dietary supplement meticulously crafted to address both sleep concerns. aid metabolism. and promote overall well-being. Powered by nature's most potent ingredients, lgNIGHTserves as the industry's pioneer product to feature Sleeproot Valerian™ . one of the most powerful forms of Valerian available on the market. lgNIGHT combines this with Shoden® Ashwagandha, a proven powerhouse to balance circadian rhythm and provide hormonal support. DHH-8, a mood support derived from magnolia bark. and CalorieBurn GP® , a metabolic and weight management supportderived from the clinically-studied grains of paradise.

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN BENEFITS

Sleep&MetabolismOptimization' DietarySupplement 30Capsules

PATIENTS REQUIRING

• Sleep Quality or Management Concerns

• Restorative, Deep Sleep, & REM Support

• Metabolic & Weight Management Support

Quality Sleep

Promotes Leaner Body Composition

DIRECTIONS:

Take1 capsule 30 mins before bedoras directed byyourhealthcarepractitioner. SHOULDNOT BETAKENWITHALCOHOL

SUPPLEMENT FACTS

ServingSize:1Capsule ServingsPerContainer:30 AmountPerServing %DV

Sleeproot Valerian™ (Valerianaofficialis) 200mg

Root Extract (Standardized to2% Valerenic Acid)

Shoden• Ashwagandha (Withaniasomnifera) 120 mg Extract (root and leaO (35% Withanolides)

CaloriBurn GP0 Grains of Paradise Seed Extract (6-Paradol 12.5%)

DHH-B (Dihydrohonokiol-8) (derived from magnolia bark)

•DailyValueNotEstablished

40mg 1.5mg

OtherIngredients:VegetableCapsule(Hypromellose), RicePowder,MagnesiumStearate,SiliconDioxide

INGREDIENTS

❖

+ Sleeproot

Sleeproot Valerian™ -At the heart of lgNIGHT lies Sleeproot'". a novel form of Valerian (Valeriana somnifera novus).Sleeproot™ extract contains 2% valerenic acid.This high active content sets it apart from other valerian products on the market. which typically only contain on average 0.8% valerenic acid.Valerian has long been cherished for its ability to induce tranquility and aid in sleep. but Sleeproot™ takes it to a new level.The secret to Sleeproot's success lies in its interaction with the brain's gamma-aminobutyric acid (GABA) receptors.GABA is nature's calming messenger. and Sleeproot enhances its activity. soothing the central nervous system and inviting restfulness.1•2

Moreover.Valerianassists inregulating the sleep-wake cycle by influencingmelatonin production. the body's sleep-regulating hormone. Sleeproot'" in particular has been clinically studied and found to facilitate profound. statistically significant improvements in the amount of time it takes to fall asleep. sleep duration. sleep efficiency. reduction in daytime sleepiness and waking up feeling refreshed.

SH DEN.

Shoden® Ashwagandha - To conquer the pervasive stress that can disrupt our nights. lgNIGHT utilizes Shoden® . an enriched form of ashwagandha (Withania somnifera).Shoden's potency is expressed in its 35% withanolide content. the bioactive compounds responsible for its impressive stress-reducing and sleep-improving capabilities.

A pivotal study on Shoden® demonstrated its remarkable impact on sleep quality and duration.In this study. participants experienced a 42% increase in restorative sleep. accompanied by an additional 36 minutes of high-quality sleep and an increase of 39 minutes in overall sleep duration.The time it took to fall asleep also decreased by a significant 11.8%.These findings underscore Shoden's ability to enhance sleep by promoting restorative deep sleep phases and reducing the time it takes to transition into slumber.3

These impressive results can be attributed to Shoden..s role as an adaptogen. helping the body adapt to stress and regulate the hypothalamic-pituitary-adrenal (HPA) axis. which controls the release of stress hormones like cortisol.Lower cortisol levels bring about a sense of serenity. reduced anxiety. and ultimately. higher sleep quality.Additionally. Shoden"'s influence on neurotransmitters like serotonin lends a mood-enhancing touch to its repertoire.4 Shoden"'s role within lgNIGHT. is to encourage thejourney towards not only better sleep but a restorative one.

DHH-8

Dihydrohonokiol-B (DHH-B). derived from magnolia bark. is a natural sedative that heightens the activity of GABA receptors in the brain. similar to Sleeproot'".This mechanism fosters inhibitory signaling. coaxing the nervous system into a state of relaxation. an essential prerequisite for restful sleep.DHH-B is a known for those grappling with stress-related sleep disturbances.As anxiety subsides. sleep quality naturally improves.5

CALORlaUrSl!N;)®

CaloriBurn GP® - While sleep is often associated with rest. lgNIGHT goes the extra mile to turn sleep into a metabolic powerhouse. thanks to CalorieBurn GP® . extracted from grains of paradise.This unique ingredient ignites the concept of thermogenesis. where the body generates heat and burns calories.Within grains of paradise lies 6-paradol. a potent compound that supports brown adipose tissue (BAT). renowned for its calorie-burning prowess.By activating BAT. CalorieBurn GP® revs up metabolism and burns calories. even during the tranquil hours of sleep. assisting in weight management and overall metabolic health.6

REFERENCES

1. Shinjyo N, Waddell G, GreenJ. Valerian Rootin Treating Sleep Problems and Associated Disorders-A Systematic Reviewand Meta-Analysis. J Evid Based lntegrMed. 2020Jan-Dec;25:2515690X20967323.doi:10.1177/2515690X20967323. PMID: 33086877; PMCID:PMC7585905.

2. Bent S, PadulaA, MooreD, Patterson M, MehlingW. Valerian forsleep:a systematic reviewandmeta-analysis. AmJMed. 2006Dec;l19(12):1005-12. doi: 10.1016/j.amjmed.2006.02.026.PMID:17145239;PMCID:PMC4394901.

3. DeshpandeA, Irani N, BalkrishnanR, BennyIR. Arandomized, doubleblind, placebocontrolledstudyto evaluatetheeffectsof ashwagandha (Withaniasomnifera)extractonsleep qualityin healthyadults. Sleep Med. 2020Aug;72:28-36. doi: 10.1016/j.sleep.2020.03.012. Epub 2020Mar 21. PMID: 32540634.

4. LoprestiAL, Smith SJ, Ma/vi H, Kodgule R. Aninvestigationintothe stress-relievingand pharmacological actions ofanashwagandha(Withania somnifera)extract:Arandomized, double-blind, placebo-controlledstudy. Medicine (Baltimore). 2019 Sep;98(37):e17186. doi: I0.1097/MD.0000000000017186.PMID: 31517876; PMGID: PMC6750292.

5. WoodburyA, Yu SP, Wei L, GarcfaP. Neuro-modulating effectsofhonokiol:areview. Front Neurol. 2013 Sep11;4:130. doi: 10.3389/fneur.2013.00130. PMID: 24062717; PMGID: PMC3769637.

6. Sugita J, YoneshiroT, Sugishima Y, Ikemoto T, Uchiwa H, SuzukiI, SaitoM.Dailyingestionofgrainsofparadise (Aframomum melegueta) extract increases whole-body energy expenditureanddecreases visceralfatin humans. J Nutr Sci Vitaminol (Tokyo). 2014;60(1):22-7.

lnfiniAGE™

OMICmAge Optimization*

lnfiniAge™ representslnfiniWell'smostnovelinnovationdrivenbyobjective geneticdataandhasbeenshowntohelpimprovetheagingprocessinthe latestresearchfromHarvardUniversityandTruDiagnostic.Asweage,our bodies,organs,andcellsundergotransformationsthatimpactourwell-being andlifespan.Thesechangesarecomplex,however,inarecentpublication whichdescribesthecreationofanewepigeneticagealgorithm,scientists wereabletofindnovelmetabolomicandproteomicassociationsintothe reasonwhyweage.Thisculminatedinanewepigeneticagealgorithmcalled OMICmAgewhichisthebestperformingepigeneticclocktodate.Itisthe onlyepigeneticclockwithgreaterthan90%accuracyofdeathprediction within10years.ThisepigeneticclockisthedrivingforcebehindlnfiniAge™

DEMOGRAPHIC & CLINICAL APPLICATIONS

MEN & WOMEN

BENEFITS

AidsAntioxidant Capacity

Optimizes Mitochondrial Function

PATIENTSREQUIRING

•LongevityProtocols

•EpigeneticSupport

•CardiometabolicSupport

•NeurologicalSupport

DIRECTIONS:

Take2capsulesdailyorasdirected byyourhealthcarepractitioner.

SUPPLEMENT FACTS

ServingSize:2CapsulesIServingsPerContainer:30

PromotesCholesterol Profiling

Supports Healthy Inflammatory Response Optimizes Nutrient Sensing Pathways

Calciumalpha-ketoglutarate) N-AcetylL-Cysteine

* Lutein 15mg *

EclipseBio-AgeComplex'" 1,025mg * Calciumalpha-ketoglutarate,Uridinemonophosphate, L-Ergothioneine,ChokeberryExtract (AroniaMelanocarpa)

•DailyValueNotEstablished

OtherIngredients:MagnesiumStearate,Silicon Dioxide,VegetableCapsule(Hypromellose)

Supports Cognitive Function & Brain Aging

OVERVIEW

Animportantstepintheresearchwasleveragingartificialintelligencetofindnovelmetaboliteandproteomicassociations to biological aging. During this process. Harvard researchers asked which metabolites. clinical values. and proteins were most predictive of longevity. They found a total of 38 individual factors which were predictive of time until death. Furthermore, they were able to find several nutrition-related biomarkers which we used to design the best in class supplementto improveepigeneticaging.Together.we believe that lnfiniAge'"is thestrongestcombinationof ingredients to reverse the most predictive. biological age biomarkers to date.

Based on that information. lnfiniAge™ was born. It contains a precise blend of? key ingredients. including Calcium Alpha-Ketoglutarate, Uridine Monophosphate, Ergothionine. N-Acetyl L-Cysteine. Lutein (Carotene-2,2,-diol) Aronia Melanocarpa Extract,and Zinc. Many oftheseingredients have vast publications whichdescribeamultitudeof benefits with regard to the aging process. We havealso included what could be considered novel ingredients, relativeto longevity, into this formulation as well. Each of these has been specifically identified in theOMICm Age algorithm which can beneficially impactOMICm Age factors.

Forinstance,inthedevelopmentofOMICmAge,wetookintoeffectthatindividualswhohadhigherplasmaconcentrations of Uridine and Lutein were generally associated to have a better OMICm Age; and as a resuIt. have longer ives with less morbidity. We also included ingredients to change other OMICm Age measured variables. such as zinc and Aronia Melanocarpa Extract. Zinc and Aronia Melanocarpa Extract help to increase PON1.

Serum paraoxonase and arylesterase 1 (PON1) is an enzyme encoded by the PONl gene. Serum PONl is secreted mainly by theliver.althoughlocal synthesisoccursinseveraltissues.PONl proteinisfoundinalmostalltissues.PONl isalsoamajor anti-atheroscleroticcomponentof HDL Cholesterol (goodcholesterol).ThePONl gene isactivatedbyPPAR-y, whichincreases synthesisandreleaseofparaoxonase1 enzymefromtheliver,reducingatherosclerosis. IntheOMICmAgecohort,researchers found that higher levels of PON1 activity were associated with better aging. Some studies have shown that Aronia Melanocarpa Extract can increase PONl activity levels by over 15%.

INGREDIENTS

Zinc

Zinc.anutrientfoundthroughoutyourbody,helpsyourimmunesystemandmetabolismfunction.Zincisalsoimportantto woundhealingandyoursenseoftasteandsmell. However. likearoniamelanocarpaextract.ithasalsobeenshowntosupport PONl activitylevels.Inadditiontothis,thefirsttrialonepigeneticagereversal(the TRIMMTrial).alsosupplementedwith zinc.1 3

N-Acetyl L-Cysteine

N-Acetyl L-Cysteine (NAC). a derivative of the amino acid cysteine, has been of interest in the context of longevitydueto its potential impact on various mechanisms associated withaging. NAC isa precursor to glutathione. a keyantioxidant in the body,and it playsa crucial role inmitigating oxidative stressandprotectingcells from damage.Additionally, NAChas been investigated for its ability to influence cellular processes such as apoptosis and DNA repair. Some studies. particularly in animalmodels. havesuggestedthat NACsupplementationmayhaveapositiveinfluenceonlongevitybypromotinghealthier agingand reducing the risk of age-related diseases. Nevertheless. the exact mechanisms and its application to human longevity warrant further research to establish a clear causal relationship.4 5

In the creation ofOMICm Age. we see thathighercystine levels are negative for biologicalaging. This is most likely because cystineisupregulatedwithoxidativestress.6 Supplementationswithglutathioneprecursorsmighthelpreducethisoxidative stress burdenand improve OMICm Age.

INGREDIENTS

Epicatechin

Epicatechin, found in dark chocolate, green tea, and certain fruits, belongs to the catechin family of flavonoids. It has garnered attention for its potential to promote muscle growth, enhance exercise performance, and support overall health.1 2

One of the ways epicatechin works is by inhibiting myostatin, a protein that limits muscle growth.3 By blocking myostatin, epicatechincanpotentiallyincreasemuscleproteinsynthesis,leading tomusclegrowth.Additionally.epicatechinenhances theproductionofnitricoxide, whichimprovesblood flow andnutrient deliverytothemuscles. This increased circulationmay furthersupportmusclegrowthandexerciseperformance.Anotherbeneficialmechanismofepicatechinisitsabilitytostimulate mitochondrialbiogenesis,resultingintheproductionofnewmitochondria.This, inturn,enhancesendurance,energyproduction, andoverallmusclefunction. Epicatechinhasbeenshowntopromotemuscleprotein synthesis,increasingmusclegrowthand strength.Epicatechinhasalsobeenassociatedwithincreasedmusclefibersize,contributingtomusclehypertrophyandimproved muscle density. Improved blood flowand nitric oxide productionfacilitated byepicatechincan enhance exerciseperformance, including endurance, strength, and power output.1

eHMB

myHMB® contains[3-Hydroxy[3-Methylbutyrate (HMB).ametaboliteoftheessentialaminoacidleucine. Ithasgainedpopularity for its potential benefits in muscle recovery, strength, and exercise performance.4 5 myHMB® consists of pure [3-Hydroxy [3-Methylbutyrate (HMB). a naturallyoccurringcompoundfound in small amounts in certain foods. HMB is produced during the breakdown of leucine, an essential amino acid.

HMB exerts its effectsthroughseveralmechanisms. It stimulatesproteinsynthesis,supportingmuscle growth, repair, and maintenance. HMB also reduces muscle proteinbreakdown,preservinglean muscle mass during intenseexercise, caloric restriction. ormuscle-damagingconditions. Additionally. HMBpossessesanti-inflammatoryproperties.whichcanhelp reduce exercise-induced muscle damage and promote recovery. HMB supplementation accelerates recovery from intense exercise, reducesmusclesoreness.andpromotesrepairandadaptation.HMBmayalsoenhancemusclestrengthandpower,particularly inindividualsengagedinresistancetrainingorhigh-intensityactivities. Ithasshownpromiseinpreventingmusclelossduring caloric restriction, aging, or situations wheremuscle breakdownmayoccur. 6

Purpleforce· GHG"

PurpleForce® Purple Tea isderivedfromauniquecultivarofCamelliasinensisknownaspurpletea. Itcontainsbioactivecompounds that contribute to potential health benefits. PurpleForce® PurpleTea is made from the leaves of a specially cultivated purple tea plant (Camellia sinensis). It contains anthocyanins. catechins (including epicatechin). flavonoids, and other polyphenols.

Mechanistically, PurpleForce® PurpleTeaimprovesantioxidantactivity,thankstoitshighlevelsofanthocyaninsand catechins. These antioxidants help combat oxidative stress and reduce exercise-induced free radicals. aiding in muscle recoveryand reducingmuscledamage.Thebioactivecompoundsinpurpleteacanmidigateexercise-inducedmusclesoreness.Additionally, purple tea enhances nitric oxide production, improving blood flow and nutrient delivery to the muscles. which may supportmusclegrowthand performance.7

PurpleForce® Purple Tea aids in post-exercise recovery by leveraging its antioxidant to reduce muscle soreness and support muscle repair. Purple tea's catechins. including epicatechin. may increase muscle protein synthesis. promoting muscle growth and strength. It may also enhance exercise performance, including endurance, strength, and power output. through improved blood flow and nutrient delivery. Moreover, the high antioxidant content of purple tea contributes to overallhealth,supportingimmunefunctionand cardiovascular health.8

REFERENCES-

1. Schomburg, L (20JJ). Selenium, se/enoproteins and the thyroid gland: interactions in health and disease. Nature Reviews Endocrinology, 8(3), 160-171.

2. Venditti, P., & DiMeo, S. (2006). Thyroid hormone-induced oxidative stress. CellMo/ Life Sci, 63(4), 414-434.

3. Gartner, R., & Gasnier, B. C. (2003). Selenium in the treatment of thyroid diseases. European Journal of Endocrinology, 148(1), 9-13.

4. Gereben, B., Zavacki, A.M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., ... & Zeo/d, A. (2008). Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocrine Reviews, 29(7), 898-938.

5. Nacamul/i, D.,Mian, C., Petricca, D., Lazzarotto, F., Baro/lo, S.,Pozza, D., ... & Gire/Ii,M. E. (2010). Influence of physiological dietary selenium supplementation on the natural course of autoimmune thyroiditis. Clinical Endocrinology, 73(4), 535-539.

6 Zimmermann,M. B. (2009). Iodine deficiency. Endocrine Reviews, 30(4), 376-408.

7. Kopp. P. (2009). Perspective: genetic defects in iodide handling. Endocrinology, 150(3), 1084-1088.

8. Aghini-Lombardi, F., Antonangeli, L,Martino, E., Vitti, P., Maccherini, D., Leoli, F., & Pinchera, A. (1999). The spectrum of thyroid disorders in an iodine-deficient community: thePescopagano survey. The Journal of Clinical Endocrinology &Metabolism, 84(2), 561-566.

9. Knapen,M. H., Drummen, N. E., Smit, E., Vermeer, C., & Theuwissen, E. (2013).Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International, 24(9), 2499-2507.

JO. Razzaque, M. S. (2018). Does vitamin K2 deficiency contributeto increased risk of cardiovasculardiseasein dialysis patients? Medical Hypotheses, JJO, 32-34.

JJ. Potdar, D., Hirwani, R., & Dhulap, S. (2014).Phyto-chemica/ and pharmacological applications of Commiphora species.AsianPacific Journal of Tropical Medicine, 4(12), 952-960.

12. Panda, S., & Kar, A. (2005). Gugu/u (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation. Life Sciences, 77(21), 2782-2792.

13. Seoane-Co//azo, P., Fern0, J., Gonzalez, F., Dieguez, C., & Leis, R. (2015).Hypothalamic-autonomic control of energy homeostasis. Endocrine, 50(2), 276-291.

Corona, G., Spencer, J.P., Dess,,M.A., & Extra, J.M. (2009).Hydroxytyrosol, tyrosol and derivatives and their potential effects on human health. In 14. NaturalProducts (pp. 1-24). Springer.

JS. Bu/otta, S., Celano,M., Lepore, S.M., Montalcini, T., Pujia, A., & Russo, D. (20ll). Beneficial Effects of Olive Oil Polyphenols on the Impaired Endothelial Function and Elevated BloodPressure Induced by Acute Consumption ofTartrazine inHealthy Young Adults. International Journal of Food Sciences and Nutrition, 62(8), 806-812.

16. Mehmood,M. H., Siddiqi,H. S., Gilani, A.H., & Ahmed, A. (201l).Antioxidant and protective effect of hydroxytyroso/ acetate against oxidative stress in human erythrocytes. Drug Research, 61(12), 707-7JJ.

17. Nistico, S., Ehrlich, J., Gajowiak, A., & Niedzwiecki, A. (2018). Hydroxytyroso/:Health Benefits and Use as Functional Ingredient inMeat andMeat Products. Molecules, 23(9), 2329.

18. Cubeddu, L X., Cubeddu, R. J., Heimowitz, T., &Hoffman, J. (1981). Comparative bronchodi/ating activity of theobromine and theophylline in patients with chronic obstructive lung disease. Chest, 80(6), 740-744.

19. Tseng, Y. H., & Kung, J. T. (1995). Effects of theobromine on adenosine and thyroid hormone levels in the rat. Pharmacology, 50(1), 24-31.

20. De Lange, P., Senese, R., Cioffi, F.,Moreno,M., Lombardi, A., Silvestri, E., & Lanni, A. (20ll). Rapid activation by 3, S, 3'-L-triiodothyronine of adenosine 5'-monophosphate-activated protein kinase/acetyl-coenzyme A carboxylase and Akt/protein kinase B signaling pathways: relation to changes in fuel metabolism and myosin heavy-chain protein content in rat gastrocnemius muscle in vivo. Endocrinology, 152(2), 605-616.

21. Lombardi, A., de Lange, P., Silvestri, E., Busie/lo, R. A., Lanni, A., & Goglia, F. (2015).Moreno,M.Metabolic effects of thyroid hormone derivatives. Thyroid, 25(10), ll92-1201.

22. Senese, R., Cioffi, F., de Lange, P., Goglia, F., & Lanni, A. (2013).Thyroid: biological actions of 'nonc/assica/' thyroid hormones. Journal of Endocrinology, 218(1), Rl-Rl2.

COS METIC PEPTIDES