CDEF
CytoPharma GmbH
contact
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Derma Tools Biotech GmbH
Klappacher Str. 126 D-64285 Darmstadt +49 (0) 6151/9 51 88 14 +49 (0) 6151/9 51 58 13 info@cytopharma.de www.cytopharma.de Dr. Chris Schäfer
business activities
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Therapeutics Diagnostics Contract Research & Development Production Sales Services Training Lab Equipment Clinical Research (CRO)
application Agriculture Engineering Chemistry Food/Feed Medicine/Pharmaceuticals Env. Protection Consulting
profile CytoPharma GmbH was the first company to succeed in elucidating the physiological cause and molecular mechanism of arteriosclerosis and restenoses (post-operative reoccurrences of blood vessel narrowing). The cause of arteriosclerosis lies in damage to the endo thelial cells, which form a tile-like lining of all blood vessels throughout the body. Endothelial cell injury and necrosis give rise to vacant areas in which deposits become estab lished. These lead progressively to a hardening of the vessel, resulting in massive disturbances of circulation which can lead to myocardial infarction or apoplectic stroke. By specific use of newly developed active ingredients, CytoTools GmbH succeeded in stopping endothelial necrosis, thus reducing the deposition process in injured blood vessels.
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contact Klappacher Str. 126 D-64285 Darmstadt +49 (0) 6151/9 51 58 12 +49 (0) 6151/95 15 13 kontakt@dermatools.de Dr. Mark Freyberg, Dr. Dirk Kaiser Dr. Dirk Kaiser, Dr. Mark Freyberg
business activities Therapeutics Diagnostics Contract Research & Development Production Sales Services Training Lab Equipment Clinical Research (CRO)
application Agriculture Engineering Chemistry Food/Feed Medicine/Pharmaceuticals Env. Protection Consulting
profile Both in chronic wounds and in burns and scalds, a certain type of cell in the connective tissue, known as the fibroblast cell, is present in too small numbers. But fibroblasts play an essential role in the wound healing process. Derma Tools succeeded in locating the reasons for wound healing problems at the molecular level. Special attention was directed at the cause and mechanism of apoptosis (programmed cell death) of fibroblasts in the connective tissue of the skin. These studies were the first to identify the trigger for the programmed cell death of fibroblasts. The therapeutic approach thus focuses on two stages in the cell cycle – reduction of apoptosis and enhancement of cell division. As a result, there is an increase in the numbers of fibroblasts needed for wound healing. This has already been confirmed in tests with cultured cells and initial treatments of patients, and documented in scientific publications.