05/05/2011
Content • Pharmacodynamics – Dose-response curves
• Pharmacokinetics
Pharmacology Review
– Apparent volume of distribution – Half-life – Clearance – Steady state
Created by Sebastian Leuschner ©
Pharmacodynamics What the drug does to the body...
Pharmacokinetics What the body does to the drug...
Metabolism • Phase I – Derivation (e.g. oxidation) – Relatively minor change – exposes reactive group – Cytochrome P450 (CYP450)
• Phase II
Questions?
– Conjugation (e.g. glucuronidation) – Significantly increases water solubility
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