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Essential Cell Biology provides an accessible introduction to the fundamental concepts of cell biology. Its lively writing and exceptional illustrations make it the ideal textbook for a first course in cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive, conceptual framework of the basic science that underlies our current understanding of biology. The Third Edition is thoroughly updated scientifically, yet maintains the academic level and size of the previous edition. The book is accompanied by a Media DVD-ROM with over 130 animations and videos, all the figures from the book, and a new self-test quizzing feature for students.

NEW IN THE THIRD EDITION u Completely updated throughout. u Based on student and instructor feedback, the Third Edition now includes: • • • •

Integration of cell cycle and cell division into a single chapter. Improved treatment of thermodynamics and energetics. Integration of multi-media throughout text. The addition of a quizzing feature to the Media Player.

u Greater focus on regulation, including new material on chromosome structure and epigenetics, post-transcriptional control (riboswitches, microRNAs, and RNAi), and metabolic controls.

u Additional attention to disease and medicine, including new material on quality control u u u u

in protein production, cell-cell recognition, genetic variation, cancer treatments, and enhanced coverage of stem cells and their potential to treat disease. New treatment of genome evolution and comparative genomics. New coverage of modern recombinant DNA and cell visualization technologies. New “How We Know” sections. Revised Question Bank for instructors including questions that can be used with student response systems (i.e. clickers).

HALLMARK FEATURES u The authors are known worldwide for their research, teaching, writing, and leadership in science and science education.

u The text reflects the accuracy, authority, and currency of the renowned Molecular Biology of the Cell, but it is written at an introductory level.

u Concept headings descriptively introduce each section. u The art program emphasizes central concepts without unnecessary detail. u “How We Know” sections in every chapter introduce experimental science by explaining both the methods and scientific intuition of classical and current experiments.

u Questions interspersed throughout and at the end of each chapter test students’ understanding and stimulate curiosity (all questions answered in the back of the book).

u Panels that concisely review

basic science, principles, pathways, as well as other topics.

u Key terms in text listed at the end of each chapter.

u Detailed, illustrated glossary. u “Essential Concepts” review for each chapter.

CONTENTS 1. 2. 3. 4. 5. 6. 7. 8. 9. 10.

Introduction to Cells Chemical Components of Cells Energy, Catalysis, and Biosynthesis Protein Structure and Function DNA and Chromosomes DNA Replication, Repair, and Recombination From DNA to Protein: How Cells Read the Genome Control of Gene Expression How Genes and Genomes Evolve Manipulating Genes and Cells

11. 12. 13. 14. 15. 16. 17. 18. 19. 20.

Membrane Structure Membrane Transport How Cells Obtain Energy from Food Energy Generation in Mitochondria and Chloroplasts Intracellular Compartments and Transport Cell Communication Cytoskeleton The Cell Division Cycle Genetics, Meiosis, and the Molecular Basis of Heredity Tissues and Cancer

To download a detailed table of contents and sample chapters, please visit:

THE AUTHORS Bruce Alberts received his Ph.D. from Harvard University and is Professor of Biochemistry and Biophysics at the University of California, San Francisco. He is the editor-in-chief of Science magazine. For 12 years he served as President of the U.S. National Academy of Sciences (1993-2005). Dennis Bray received his Ph.D. from Massachusetts Institute of Technology and is currently an active emeritus professor at University of Cambridge. In 2006 he was awarded the Microsoft European Science Award. Karen Hopkin received her Ph.D. in biochemistry from the Albert Einstein College of Medicine and is a science writer in Somerville, Massachusetts. Alexander Johnson received his Ph.D. from Harvard University and is Professor of Microbiology and Immunology and Director of the Biochemistry, Cell Biology, Genetics, and Developmental Biology Graduate Program at the University of California, San Francisco.

Julian Lewis received his D.Phil. from the University of Oxford and is a Principal Scientist at the London Research Institute of Cancer Research UK.

Martin Raff received his M.D. from McGill University and is at the Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit and in the Biology Department at University College London.

Keith Roberts received his Ph.D. from the University of Cambridge and is Emeritus Fellow at the John Innes Centre, Norwich. Peter Walter received his Ph.D. from The Rockefeller University in New York and is Professor and Chairman of the Department of Biochemistry and Biophysics at the University of California, San Francisco, and an Investigator of the Howard Hughes Medical Institute.

April 2009 • 860 pages • 850 illustrations Paperback • 978-0-8153-4130-7 • £45.00

Hardback • 978-0-8153-4129-1 • £94.00

TEACHING SUPPLEMENTS The Art of Essential Cell Biology, Third Edition The images from the book are available in two convenient formats: PowerPoint® and JPEG. They are located in folders on the Media DVD-ROM or can be downloaded on the Web from Classwire™. On Classwire the individual JPEGs are searchable by figure number, figure name, or by keywords used in the figure legend from the book.

Figure Integrated Lecture Outlines The section headings, concept headings, and figures from the text have been integrated into PowerPoint presentations. These will be useful for instructors who would like a head start creating lectures for their course. Like all of our PowerPoint presentations, the lecture outlines can be customized. For example, the content of these presentations can be combined with videos from the DVD-ROM and questions from the book or “Question Bank,” in order to create unique lectures that facilitate interactive learning in the classroom.

Question Bank The instructor Question Bank has been expanded with new questions. Each chapter will contain between 50-60 questions, and approximately 20-25 of those will be new. Special effort has been made to create more multiplechoice questions that can be used with student response systems (i.e. clickers). In addition to the multiple-choice questions, the Question Bank includes: fill-in-the-blank questions, matching questions, true/false questions, and concept questions or “thought questions,” which are particularly challenging. The Question Bank is available on Classwire.

Media DVD-ROM The Media DVD-ROM comes with every copy of the book and includes the Essential Cell Biology Interactive media player. Details about the DVD-ROM are located in the column to the right.

Garland Science Classwire™ All of the instructor supplements are available to qualified instructors online at the Garland Science Classwire Website. Garland Science Classwire offers access to other instructional resources from all of the Garland Science textbooks, and provides free online course management tools. For additional information, please visit or e-mail (Classwire™ is a trademark of Chalkfree, Inc.)

MEDIA DVD-ROM The Media DVD-ROM is packaged with every copy of the book. It includes:

Essential Cell Biology Interactive The Essential Cell Biology Interactive Media Player contains over 130 animations, videos, and molecular models. It also includes a cell explorer program that encourages students to investigate a set of high-resolution micrographs.

Student Self-Quizzes The quizzing feature, which is new to this edition, allows students to test themselves in basic reading comprehension of each chapter. It is accessed through the Essential Cell Biology Interactive Media Player.

Movie Vault The Movie Vault is an archive of movies from the media player in three handy formats: QuickTime®, MPEG, and iPod®.

PowerPoint Presentations The figures from the book have been preloaded into PowerPoint presentations. There is one presentation for each chapter, and the files are located in a folder on the DVD-ROM. The files are also available on Classwire.

JPEG Archive The individual figures from the book are available in JPEG format. They are organized by chapter in folders on the DVDROM. They are also available on Classwire.

MOLECULAR BIOLOGY OF THE CELL FIFTH EDITION Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter January 2008 • 1,392 pages • 1,526 illustrations Hardback • 978-0-8153-4105-5 • £110.00 Paperback • 978-0-8153-4106-2 • £59.99 Packaged with a Media DVD-ROM

For nearly a quarter century Molecular Biology of the Cell has been the leading in-depth text reference in cell biology. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries.

THE PROBLEMS BOOK John Wilson and Tim Hunt January 2008 • 608 pages • 826 illustrations Paperback • 978-0-8153-4110-9 • £25.00 Packaged with a CD-ROM (contains solutions to all problems, and figures from the book)

The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter will review key terms, test for understanding basic concepts, and pose research-based problems. The Problems Book has been designed to correspond with the first twenty chapters of Molecular Biology of the Cell, Fifth Edition. •

Includes the solutions to the end-of-chapter problems in the textbook Molecular Biology of the Cell, Fifth Edition.

Contains over 2,000 problems and their solutions.

All of the solutions to the problems in The Problems Book are on the CD-ROM that is packaged with every copy of the book.

The problems are organized into the following categories: Terms to Learn, Definitions, True/False, Thought Problems, Calculations, and Data Handling.

The Problems Book will be useful for homework assignments and as a basis for class discussion. It could even provide inspiration for exam questions.

CELLULAR SIGNAL PROCESSING AN INTRODUCTION TO THE MOLECULAR MECHANISMS OF SIGNAL TRANSDUCTION Friedrich Marks, Ursula Klingmüller and Karin Müller-Decker December 2008 • 656 pages • 428 illustrations Paperback • 978-0-8153-4215-1 • £42.50

Cellular Signal Processing is intended for use in signal transduction courses for undergraduate and graduate students. It offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication. The content is guided by three central principles: the protein network, its energy supply, and its evolution. Includes coverage of prokaryotic signal transduction through to neuronal signaling and highlights the clinical aspects of cell signaling in health and disease. •

Chapter 3 discusses the evolution of cellular signal processing by focusing on prokaryotic signal transduction, which links the major switching reactions of mammalian signalling to prokaryotic predecessors.

Chapter 17 places signal transduction in context with systems biology and describes the formation and function of networks.

Sidebars highlight complementary perspectives to the main discussion and strengthen the student’s understanding of essential concepts.

Section summaries clarify the important points within each chapter.

Essential Cell Biology, Third Edition  

Essential Cell Biology provides an accessible introduction to the fundamental concepts of cell biology. Its lively writing and exceptional i...

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