Stefanie Kuzmiski MSc Medical Art

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“Small labels to distinguish the enzymes that modify PAHs may be useful for the viewer so the names are easier to remember (and therefore the process).” “This is too complex for general public (GP) - reading age about 11 years -reference The Sun. They may be interested if presented more simply - long chemical names although later reduced to initials (too many & so confusing) are a turn off to GP This level of ‘science’ is too advanced for the motivated environmentalist from road sweeper to bank teller.”

Aesthetically there was definite room for improvement. In addition to the animation being quite dark, respondents pointed out that they were unable to tell that the PAH had changed. The model does change from the PAH to a diol epoxide, but perhaps it would help to have the camera moving even closer to the reaction. Another possibility for visually signifying the reaction could be to use some sort of light rather than simply showing the enzyme touching the particle. “…3) It’s sometimes unclear how the video relates to the dialogue. For example, we zoom in through an atom in PAH to see...a cell’s nucleus, I think? But I’m not sure. Also, we hear that the PAH is transformed by three enzymes but I couldn’t see a transformation? 4) After hearing about the 3 transformations required to make PAH carcinogenic I was left with the impression that it should be rare and unlikely to occur. But we know it’s not so rare so I presume that the enzymes are prevalent and these interactions are common. It might help to show that somehow. Just some ideas to improve on an alreadyimpressive video!”

Discussion

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