Introduction to Organic Synthesis Reasons for synthesising organic compounds: ď‚§ to proof the structure of a natural compounds ď‚§ to prepare compounds those are useful for humankind, e.g. pharmaceuticals, polymer and dyes ď‚§ to prepare specific compounds to study reaction mechanisms or biological metabolism How can you design an organic compound? How can you propose a method of preparation? What is the bond disconnection? What is the difference between synthon and synthetic equivalent? What is the good disconnection?
Target Molecule (TM): The compound we wish to prepare. The molecule whose synthesis is being planned. Disconnection ( ): is a theoretical process (paper operation), which breaks a bond and converts a molecule into a possible starting material. The reverse of a chemical reaction. A good disconnection that gives stable, commercially favor, available and highly reactive starting materials with fewest steps in preparation.
Synthon: A fragment, usually an ion, produced by a disconnection, cannot itself be used, often because it is too unstable. Synthetic Equivalent: A neutral molecule carrying out the function of a synthon.
FGI: Functional Group Interconversion: The operation of writing one functional group for another so that disconnection becomes possible and help synthetic planning. Method of preparation: is a real reaction including real molecules and experimental conditions for this reaction. It is a reverse of a bond disconnection.