Stem Cell Therapy's Role in Managing Peripheral Artery Disease | Dr David Greene

STEM CELL THERAPY'S ROLE IN MANAGING PERIPHERAL ARTERY DISEASE

Dr. David Greene R3 Stem Cell

INTRODUCTION

• Peripheral Artery Disease (PAD) defined as the narrowing or blockage of blood vessels in the legs, arms, stomach, or kidneys.

• PAD affects millions of people worldwide, leading to reduced blood flow, pain, and tissue damage.

• Stem cell therapy emerges as a promising approach for managing PAD.

UNDERSTANDING STEM CELL THERAPY

• Stem cells are undifferentiated cells capable of self-renewal and differentiation into specialized cell types.

• Two main sources of stem cells: embryonic stem cells and adult stem cells.

• Adult stem cells, such as mesenchymal stem cells (MSCs), can be harvested from various tissues, including bone marrow and adipose tissue.

MECHANISM OF ACTION

• Stem cell therapy in PAD aims to enhance blood vessel formation and promote tissue regeneration.

• MSCs possess angiogenic and immunomodulatory properties.

• MSCs can differentiate into endothelial cells and smooth muscle cells, contributing to blood vessel repair and remodeling.

BENEFITS

Benefits of stem cell therapy in PAD:

• Improved blood flow and pain relief.

• Reduced need for amputation.

• Potential for long-term tissue regeneration.

FUTURE DIRECTIONS

• Combination therapies, such as combining stem cells with growth factors or gene therapy, show promise.

• Advances in tissue engineering and 3D printing may allow for the creation of personalized vascular grafts.

CONCLUSION

• Stem cell therapy holds great potential in managing peripheral artery disease.

• Stem cell therapy has also shown the ability to reduce inflammation and promote tissue healing.

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