please see Chapter 5, “Vessel Normalization Methods: The DMT Normalization Module” •
IC1: The internal vessel circumference at which the active force production of the vessel is maximal (ie, actin-myosin interactions are optimal); this is the ideal starting circumference for the vessel being studied
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IC1/IC100 Ratio: Also known as the Normalization Factor (Norm Factor), this ratio depicts the relationship between the internal circumference at which the active force production of the vessel is maximal and the internal circumference at which the vessel experiences optimal transmural wall pressure (here 100 mmHg) for a given vessel. This value should be determined for the specific vessel being studied! Some studies refer to the IC1/IC100 ratio as “factor k”. For a brief tutorial on how the Norm Factor (IC1/ IC100 ratio) can be determined for a specific vessel type, please see Sections 5.2 and 5.3.
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