ASNTR 2019 Conference Program by Donna Morrison

ASNTR

2019

26th Annual Conference American Society for Neural Therapy and Repair

Sheraton Sand Key Resort Clearwater Beach, Florida, USA

ASNTR-2019 Conference Summary Thursday, April 25, 2019 12:00 pm to 01:00 pm

ASNTR Council Meeting - Invitation Only

01:00 pm to 04:00 pm

Trainee Workshop – Industry Partnerships in Academic Research – Beach/Gulf

04:00 pm to 06:00 pm

Conference Registration – Lobby II

04:00 pm to 05:00 pm

Trainee - Mentor Meet & Greet – Beach/Gulf

05:00 pm to 05:15 pm

Welcome - Beach/Gulf

05:15 pm to 06:15 pm

Session 1: Keynote Lecture: Joanne Kurtzberg, MD – Beach/Gulf

06:15 pm to 06:45 pm

Award Presentations – Beach/Gulf

07:00 pm to 07:30 pm

Session 2: Data Blitz – Beach/Gulf

07:30 pm to 09:00 pm

Session 3: Poster Session - Reception – Palm/Bay

Friday, April 26, 2019 Platform Presentations – Beach/Gulf 07:00 am to 01:00 pm

Conference Registration – Lobby II

07:00 am to 08:00 am

Continental Breakfast – Palm

08:00 am to 09:15 am

Session 4: Stroke, Ischemia and TBI

09:15 am to 10:30 am

Session 5: Influence of Serotonin Circuitry on Parkinsonian Symptoms

10:00 am to 10:30 am

Refreshments Available – Palm

10:30 am to 12:30 pm

Session 6: Spinal Cord Injury

12:30 pm to 01:30 pm

Free Time

01:30 pm to 03:00 pm

Session 7: Professional Development Workshop Series - I

03:00 pm to 05:00 pm

Conference Registration – Lobby II

03:00 pm to 03:15 pm

Afternoon Break Refreshments Provided – Palm

03:15 pm to 04:15 pm

Session 8: Neurotrophic Factor Delivery in PD- When do we Intervene?

04:30 pm to 05:30 pm

Session 9: Presidential Lecture: David Schaffer, PhD

06:00 pm to 07:30 pm

Beach Volleyball Competition – Faculty vs. Post Docs/Students

Saturday, April 27, 2019 Platform Presentations – Beach/Gulf 08:00 am to 12:00 pm

Conference Registration – Lobby II

07:00 am to 08:00 am

Continental Breakfast - Palm

08:00 am to 10:00 am

Session 10: Cellular Reprogramming

09:45 am to 10:15 am

Refreshments Available – Palm

10:00 am to 12:05 pm

Session 11: Precision Medicine in Neurodegenerative Disease & Emerging Neurotechnologies

12:05 pm to 01:30 pm

Free Time

01:30 pm to 03:00 pm

Session 12: Professional Development Workshop Series - II

03:00 pm to 03:15 pm

Afternoon Break Refreshments Provided - Palm

03:15 pm to 04:15 pm

Session 13: Rising Star Research – Presentations from our Top-Ranked Travel Award Winners

04:30 pm to 05:30 pm

Session 14: Roy Bakay Memorial Lecture: Howard Federoff, MD, PhD

05:30 pm to 06:00 pm

2019 Awards & Business Meeting

07:00 pm to 10:00 pm

Beach Party

ASNTR Annual Meeting Code of Conduct ASNTR is committed to making the Annual Meeting an inclusive space for sharing ideas and knowledge. The policies of the ASNTR apply to all attendees, speakers, exhibitors, staff, contractors, volunteers, and guests at the Annual Meeting and related events. ASNTR prohibits any form of harassment, sexual or otherwise. Harassment should be reported immediately to ASNTR on-site Meeting staff: asntr.office@gmail.com. For more information on ASNTR’s policy, please visit our website: www.asntr.org/home.

Conference Agenda Thursday, April 25th 2019 12:00 pm to 01:00 pm

ASNTR Council Meeting – Current ASNTR Officers

01:00 pm to 04:00 pm

Trainee Workshop – Beach/Gulf “Industry Partnerships in Academic Research”

04:00 pm to 06:00 pm

Conference Registration – Lobby II

04:00 pm to 05:00 pm

Trainee – Mentor Meet & Greet – Beach/Gulf

05:00 pm to 05:15 pm

Welcome – Fredric Manfredsson & Paul Sanberg – Beach/Gulf

05:15 pm to 06:15 pm

Session 1: Keynote Lecture – Joanne Kurtzberg, MD Extending Cord Blood to Regenerative Therapies for the Brain

06:15 pm to 06:30 pm

ASNTR Memorial Award Presentation – Paul Sanberg & Evan Snyder

06:30 pm to 06:45 pm

Award Presentations – Kyle Fink & Fredric Manfredsson

07:00 pm to 07:30 pm

Session 2: Data Blitz – Beach/Gulf

07:30 pm to 09:00 pm

Session 3: Poster Session – Reception (Cash Bar) – Palm/Bay

Trainee Workshop “Industry Partnership in Academic Research” 1:00 pm – 4:00 pm Moderator: Kyle Fink

•

PARTNERING WITH INDUSTRY FROM AN ACADEMIC PERSPECTIVE Jan Nolta, Director of the Institute for Regenerative Cures, University of California, Davis

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WORKING WITH YOUR OFFICE OF TECHNOLOGY AND INNOVATION James Kovach, Director of Entrepreneurship and Innovation, University of California, Davis

•

INDUSTRY SPONSORED RESEARCH IN AN ACADEMIC LAB Robert Mays, Vice President – Regenerative Medicine, Athersys, Inc.

Session 1 Keynote Address 5:15 pm – 6:15 pm Introduction: Paul Sanberg 1-1

EXTENDING CORD BLOOD TO REGENERATIVE THERAPIES FOR THE BRAIN Joanne Kurtzberg, MD – Duke University Medical Center

ASNTR Memorial Award Presentation 6:15 pm – 6:30 pm Paul Sanberg & Evan Snyder

2019 Travel Award Presentations 6:30 pm – 6:45 pm Kyle Fink & Fredric Manfredsson

Data Blitz Beach/Gulf 7:00 pm - 7:30 pm Moderator: Tim Collier

Jenni Anttila – University of Helsinki (Travel Award Winner)

Kaveena Autar – University of Central Florida

Peter Deng – University of California, Davis (Travel Award Winner)

Nader El Seblani – University of Kentucky (Travel Award Winner)

Aurelie Joly Amado – University of South Florida (Travel Award Winner)

Khoi Le – Penn State University College of Medicine

Ron Leavitt – University of California, Irvine (Travel Award Winner)

Margo Randelman – Drexel University (Travel Award Winner)

Kevin Nash – University of South Florida

Fatemeh Shaerzadeh – University of Florida (Travel Award Winner)

Poster Session & Reception Palm/Bay Poster Session 7:30 – 9:00 pm

TEMPORAL ACTIVATION OF PATERNAL Ube3a IN ANGELMAN SYNDROME REPORTER MOUSE FOLLOWING TRANSPLANTATION OF ZINC FINGER SECRETED MESENCHYMAL STEM CELLS P. Deng, Travel award winner – University of California, Davis

ACTIVE IMMUNIZATION WITH TAU EPITOPE IN A MOUSE MODEL OF TAUOPATHY INDUCED STRONG ANTIBODY RESPONSE TOGETHER WITH IMPROVEMENT IN SHORT MEMORY AND TAU PATHOLOGY. A. Joly Amado, Travel award winner – University of South Florida

BRAIN DYSFUNCTION IN A MODEL OF GULF WAR ILLNESS CONTINUES INTO MIDDLE AGE WITH ELEVATED OXIDATIVE STRESS AND WANED MITOCHONDRIAL ACTIVITY L.N. Madhu, Travel award winner – Texas A&M University

THE AAV ALPHA SYNUCLEIN MODEL OF PARKINSON’S DISEASE – OPTIMIZATION OF GENETIC CONSTRUCTS F. Manfredsson – Michigan State University

T CELL PHENOTYPE IN MURINE OSTEOPONTIN-MEDIATED ANEURYSM HEALING K. Motwani, Travel award winner – University of Florida

FKN ACTS AS A DOUBLE-EDGED SWORD K. Nash – University of South Florida

THE ROLE OF INTERLEUKIN-6 IN MURINE ESTROGEN-DEFICIENCY ASSOCIATED CEREBRAL ANEURYSM RUPTURE D. Patel, Travel award winner – University of Florida

NEURAL PROGENITOR CELL SURVIVAL AND EXPRESSION OF PARVALBUMIN AND PROENKEPHALIN IN A JAUNDICED RAT MODEL OF KERNICTERUS J. Stanford – University of Kansas Medical Center

DISTINCT NEURONAL ENSEMBLES WITHIN THE MEMORY ENGRAM REGULATE MEMORY DISCRIMINATION AND GENERALIZATION X. Sun, Travel award winner – MIT/SUNY Upstate Medical University

LIMITED NG2 GLIAL TROPISM OF RECOMBINANT ADENO-ASSOCIATED VIRAL (rAAV)-MEDIATED GENE DELIVERY FOR IN VIVO NEURONAL REPROGRAMMING D. Peterson – Rosalind Franklin University

ISCHEMIC STROKE INDUCES DELAYED MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR (MANF) PROTEIN EXPRESSION IN BRAIN INFLAMMATORY CELLS J. Anttila, Travel award winner – University of Helsinki

CHARACTERIZING ROLE OF ADROPIN IN CEREBRAL ANEURYSM PATHOPHYSIOLOGY W. Dodd, Travel award winner – University of Florida

ASSOCIATION OF HYPERACUTE BLOOD PRESSURE PARAMETERS WITH BASELINE INFARCT VOLUME AND COLLATERAL STATUS OF PATIENTS WITH ANTERIOR CIRCULATION LARGE VESSEL OCCLUSION UNDERGOING ENDOVASCULAR THERAPY P. Moshayedi, Travel award winner – University of Pittsburgh Medical Center

SEQUENTIAL COMBINED TREATMENT OF PIFITHRIN-Α AND POSIPHEN ENHANCES NEUROGENESIS AND FUNCTIONAL RECOVERY AFTER STROKE F. Turcato, Travel award winner – University of Cincinnati

MAXIMUM TOLERATED DOSE OF EXOSOMES DERIVED FROM MESENCHYMAL STEM CELLS VIA INTRA-ARTERIAL DOSING IN A RAT STROKE MODEL M. Watanabe, Travel award winner – University of Miami

ACUTE TREATMENT OF A HYPOTHERMIC COMPOUND ATTENUATES PSYCHOLOGICAL DEFICITS CHRONICALLY DEVELOPED IN MICE WITH A FOCAL ISCHEMIC STROKE W. Zhong, Travel award winner – Emory University

DEVELOPMENT AND CHARACTERIZATION OF HIPSC CORTICAL NEURONS AND THEIR APPLICATION TO DRUG EVALUATION IN CNS DISEASE MODELS K. Autar – University of Central Florida

THE ROLE OF eIF5A IN TDP-43 PATHOLOGY IN FTD; THE TIP OF THE ICEBERG? Z. Quadri, Travel award winner – University of South Florida

HUMAN EMBRYONIC RETINAL PIGMENT EPITHELIAL CELL (hRPEC) GRAFTS PROVIDE IMMUNOMODULATION OF THE HOST MICROENVIRONMENT THROUGH SECRETED CYTOKINES K. Venkiteswaran – Penn State University Medical Center

SURAL NERVE GRAFTING AS A CELL-BASED DISEASE MODIFYING THERAPY FOR PARKINSON’S DISEASE N. El Seblani, Travel award winner – University of Kentucky Medical Center

UNILATERAL OPTOGENETIC OR CHEMOGENETIC INHIBITION OF THE NIGROSTRIATAL PATHWAY CAUSES REVERSIBLE HEMIPARKINSONISM THAT IS NOT ASSOCIATED WITH SPONTANEOUS OR LEVODOPA INDUCED DYSKINESIAS K.-M. Le – Penn State University College of Medicine

GUTTING THE PARKINSON'S BRAIN OF INFLAMMATION: HUMAN UMBILICAL CORD BLOOD STEM CELLS AND PLASMA TARGET GUT-BRAIN AXIS J.-Y. Lee – University of South Florida

LITHIUM CHOLESTEROL SULFATE: A NOVEL POTENTIAL TREATMENT FOR ALZHEIMER’S DISEASE AND AUTISM SPECTRUM DISORDER D. Shytle – University of South Florida

IN VIVO MAPPING OF THE SPATIO-TEMPORAL INVASION OF IMMUNE CELLS INTO EXTRACELLULAR MATRIX HYDROGEL IN A RAT MODEL OF STROKE USING 19F MAGNETIC RESONANCE IMAGING M. Modo – University of Pittsburgh

IN VIVO DELIVERY OF LARGE PLASMIDS AND CRISPR-Cas9 TO EDIT GFP GENE USING DENDRIMER NANOPARTICLES B. Srinageshwar, Travel award winner – Central Michigan University

EVALUATION OF DNA-BINDING DOMAINS TO SELECTIVELY REDUCE THE EXPRESSION OF MUTANT HUNTINGTIN IN PATIENT-DERIVED CELLS AND TRANSGENIC MICE K. Fink – University of California, Davis

POTENTIAL BENEFITS OF ENVIRONMENTAL ENRICHMENT IN A RODENT MODEL OF TAUOPATHY R. Gorzek, Travel award winner – University of Wisconsin, Madison

REPARATIVE EFFECTS OF STEM CELL FACTOR AND GRANULOCYTE COLONYSTIMULATING FACTOR IN AGED APP/PS1 MICE X. Guo, Travel award winner – SUNY Upstate Medical University

THE CONTRIBUTION OF STEM CELL FACTOR AND GRANULOCYTE-COLONY STIMULATING FACTOR IN REDUCING NEURODEGENERATION AND PROMOTING NEURAL NETWORK REORGANIZATION AFTER TRAUMATIC BRAIN INJURY J. He, Travel award winner – SUNY Upstate Medical University

INTRAVENOUSLY ADMINISTERED HUMAN NEURAL STEM CELL-DERIVED EXTRACELLULAR VESICLES AMELIORATE CRANIAL RADIATION-INDUCED BRAIN INJURY R. Leavitt, Travel award winner – University of California, Irvine

PROLYL OLIGOPEPTIDASE AND ITS INHIBITION ON ALPHA-SYNUCLEIN TOXICITY – A POSSIBILITY FOR DISEASE-MODIFYING THERAPY FOR PARKINSON’S DISEASE T. Myöhänen – University of Helsinki

EFFECTS OF UBE3A OVEREXPRESSION IN SPRAGUE DAWLEY RATS A.W. Nenninger, Travel award winner – University of South Florida

USE OF DENDRIMER NANOPARTICLES ENCAPSULATED CURCUMIN AS A POTENTIAL THERAPY FOR GLIOBLASTOMA IN MICE J. Rossignol – Central Michigan University

EFFECT OF CHRONIC NEUROINFLAMMATION ON THE CLEARANCE OF MACROMOLECULES FROM THE RAT BRAIN S. Suresh, Travel award winner – Central Michigan University

INTRANASAL ADMINISTRATION OF EXOSOMES FROM HUMAN iPSC-DERIVED NSCs ENHANCES NEURAL STEM/PROGENITOR CELL PROLIFERATION AND NEUROGENESIS IN THE NORMAL ADULT HIPPOCAMPUS R. Upadhya, Travel award winner – Texas A&M Health Science Center

CONDITIONED MEDIUM DERIVED FROM ENDOTHELIAL PROGENITOR CELLS EXERTS NEUROPROTECTION ON CULTURED CORTICAL AND MIDBRAIN NEURONAL STEM CELLS H.R. Widmer – University of Bern

MICRO RNA-2X CAN EFFECTIVELY INHIBIT ALZHEIMER'S DISEASE SYMPTOMS AND MAINTAIN MEMORY. L.-W. Wu, Travel award winner – National Dong Hwa University

PROGERIN-INDUCED AGING OF THE RAT NIGROSTRIATAL SYSTEM T.J. Collier – Michigan State University

INTERMITTENT HYPERCAPNIA TRAINING TO IMPROVE RESPIRATORY PLASTICITY FOLLOWING CERVICAL SPINAL CORD INJURY M. Randelman, Travel award winner – Drexel University College of Medicine

PHENOTYPIC CHARACTERISTICS OF THE HUMAN BONE MARROW DERIVED ENDOTHELIAL PROGENITOR CELL IN VITRO AS A POTENTIAL CELL TYPE FOR REPAIR OF THE BLOOD-SPINAL CORD BARRIER IN ALS H. Mustafa, University of South Florida

SUBCELLULAR COMPARTMENTALIZATION OF ALPHA-SYNUCLEIN ALTERS HISTONE POST-TRANSLATIONAL MODIFICATION PATTERNS AND CHROMATIN STATE IN SH-SY5Y CELLS I. Sandoval – Michigan State University

AGING INCREASES MICROGLIA SENESCENCE IN THE MIDBRAIN REGION: A RISK FACTOR IN PARKINSON DISEASE F. Shaerzadeh, Travel award winner – University of Florida

PHASE I CLINICAL TRIAL UPDATE: HUMAN NEURAL STEM CELL TREATMENT FOR PARKINSON’S DISEASE R. Gonzalez – International Stem Cell Corporation

Conference Agenda Friday, April 26th 2019 Platform Presentations – Beach/Gulf 07:00 am to 01:00 pm

Conference Registration – Lobby II

07:00 am to 08:00 am

Continental Breakfast – Palm

08:00 am to 09:15 am

Session 4: Stroke, Ischemia and TBI

09:15 am to 10:30 am

Session 5: Influence of Serotonin Circuitry on Parkinsonian Symptoms

10:00 am to 10:30 am

Refreshments Available – Palm

10:30 am to 12:30 pm

Session 6: Spinal Cord Injury

12:30 pm to 01:30 pm

Free Time

01:30 pm to 03:00 pm

Session 7: Professional Development Workshop Series - I

03:00 pm to 05:00 pm

Conference Registration – Lobby II

03:00 pm to 03:15 pm

Afternoon Break Refreshments Provided – Palm

03:15 pm to 04:15 pm

Session 8: Neurotrophic Factor Delivery in PD- When do we Intervene?

04:30 pm to 05:30 pm

Session 9: Presidential Keynote Address – David Schaffer, PhD Directed Evolution of New Viruses for Therapeutic Gene Delivery

06:00 pm to 07:30 pm

Beach Volleyball Competition – Faculty vs. Post Docs/Students

Stroke, Ischemia and TBI 8:00 am – 9:15 am Session Chairs: Anthony West & Lana Zholudeva

4-1

STRUCTURAL AND FUNCTIONAL MRI AS BIOMARKERS FOR REPAIR PROCESSES FOLLOWING STEM CELLS THERAPY OF WHITE MATTER STROKE S. Lepore, Travel award winner – University of California, Los Angeles

4-2

TRANSPLANTATION OF MESENCHYMAL STEM CELLS GENETICALLY ENGINEERED TO OVEREXPRESS INTERLEUKIN-10 INDUCES AUTOPHAGY, MITOPHAGY, MOLECULAR CHAPERONE RESPONSE AND PROTECTED NEURONAL DAMAGE IN A RAT MODEL OF TRAUMATIC BRAIN INJURY P. Maiti, Travel award winner – Ascension of St. Mary’s Hospital

4-3

HUMAN IPS-DERIVED INTERNEURONS ENHANCE FUNCTIONAL RECOVERY AFTER CORTICAL STROKE I.L. Llorente – University of California, Los Angeles

4-4

GENE EXPRESSION, MORPHOLOGICAL AND BEHAVIORAL CHANGES ASSOCIATED WITH A MOUSE MODEL OF MILD REPETITIVE TBI AND TREATMENT WITH ACTIVATORS OF Nrf2 and PPARγ W.A. Ratliff, Travel award winner – Bay Pines VA Healthcare System

4-5

DIRECT CONVERSION OF ASTROCYTES TO NEURONS ENHANCES NEURONAL REPAIR AND FUNCTIONAL RECOVERY AFTER ISCHEMIC STROKE M. Jiang, Travel award winner – Emory University

Influence of Serotonin Circuitry on Parkinsonian Symptoms 9:15 am – 10:30 am Session Chairs: Fredric Manfredsson & Lalitha Madhavan

5-1

SEROTONIN AND DOPAMINE INNERVATION OF THE BASAL GANGLIA IN PARKINSONIAN MONKEYS M. Parent – Laval University

5-2

INVESTIGATING THE ROLE OF SEROTONERGIC HYPERINNERVATION OF THE PREFRONTAL CORTEX ON PARKINSON’S DISEASE NON-MOTOR SYMPTOMS A. Roux, Travel award winner – Michigan State University

5-3

USING MULTIMODAL SEROTONINERGIC DRUGS AND GENE THERAPY AS ADJUNCT TREATMENTS FOR PARKINSON’S DISEASE A. West – Rosalind Franklin University of Medicine and Science

5-4

LEVERAGING SEROTONIN NEUROPLASTICITY TO OPTIMIZE PARKINSON’S DISEASE TREATMENT C. Bishop – Binghamton University, State University of New York

Spinal Cord Injury 10:30 am – 12:30 pm Session Chair: Michael Lane

6-1

TOP-LINE 12-MONTH RESULTS FROM THE SCISTAR STUDY - A PHASE 1/2A TRIAL OF HUMAN EMBRYONIC STEM CELL-DERIVED OLIGODENDROCYTE PROGENITOR CELLS (AST-OPC1) IN PATIENTS WITH SUBACUTE CERVICAL SPINAL CORD INJURY E. Wirth – BioTime, Inc.

6-2

EFFECTS OF MITOCHONDRIAL TRANSPLANTATION ON BIOENERGETICS AND NEUROPROTECTION FOLLOWING SPINAL CORD INJURY S. Patel – University of Kentucky

6-3

COMBINING NEURAL TRANSPLANTATION WITH THERAPEUTIC INTERMITTENT HYPOXIA TO TREAT THE INJURED SPINAL CORD L.V. Zholudeva – Drexel University

6-4

HUMAN NEURAL STEM CELL TRANSPLANTATION IN CHRONIC SPINAL CORD INJURY K.M. Piltti – University of California, Irvine

6-5

REGENERATIVE MEDICINE FOR SPINAL CORD INJURY USING IPS CELLS – FROM BENCH TO BEDSIDE N. Nagoshi – Keio University

6-6

HUMAN iPSC-DERIVED CORTICOSPINAL NEURONAL GRAFTS TO REPAIR CERVICAL SPINAL CORD INJURY G.W. Plant – Stanford University Sponsored by:

7: Professional Development Workshop Series I Methods to Promote Data Reproducibility in Laboratory Research 1:30 pm â&#x20AC;&#x201C; 3:00 pm

Hosted by: Good Research Practice Resource Center in partnership with ASNTR and the University of Kentucky Office of the Vice President for Research Guest Speakers: Greg Gerhardt, Ph.D. Richard Grondin, Ph.D. O. Meagan Littrell, Ph.D.

*Attend both workshops (4/26 & 4/27) to receive certificate

8: Neurotrophic Factor delivery in PD – When do we intervene? 3:15 pm – 4:15 pm Panel Discussion Moderator: Fredric Manfredsson

C. Lundberg – Lund University R. Mandel – University of Florida N. Polinski – Michael J. Fox Foundation

Presidential Keynote Address 4:30 pm – 5:30 pm Introduction: Fredric Manfredsson

9-1

DIRECTED EVOLUTION OF NEW VIRUSES FOR THERAPEUTIC GENE DELIVERY David Schaffer, PhD, University of California, Berkeley

Sponsored by:

Conference Agenda Saturday, April 27th 2019 Platform Presentations – Beach/Gulf 08:00 am to 12:00 pm

Conference Registration – Lobby II

07:00 am to 08:00 am

Continental Breakfast – Palm

08:00 am to 10:00 am

Session 10: Cellular Reprogramming

09:45 am to 10:15 am

Refreshments Available – Palm

10:00 am to 12:05 pm

Session 11: Precision Medicine in Neurodegenerative Disease & Emerging Neurotechnologies

12:05 pm to 01:30 pm

Free Time

01:30 pm to 03:00 pm

Session 12: Professional Development Workshop Series - II

03:00 pm to 03:15 pm

Afternoon Break Refreshments Provided – Palm

03:15 pm to 04:15 pm

Session 13: Rising Star Research – Presentations from our Top-Ranked Travel Award Winners

04:30 pm to 05:30 pm

Session 14: Roy Bakay Memorial Lecture Howard J. Federoff, MD, PhD Gene Networks Reveal New Therapeutic Targets for Neurodegenerative Diseases

05:30 pm to 06:00 pm

2019 Memorial Award Presentation & Business Meeting

07:00 pm to 10:00 pm

ASNTR Beach Party – Dinner & Dancing (Cash Bar)

Cellular Reprogramming 8:00 am – 10:00 am Session Chairs: Walter Low & Agnes Luo

10-1 TRANSLATING NEURO REPROGRAMMING FOR STROKE- WE NEED TO MOVE BEYOND THE BENCH A. Grande – University of Minnesota 10-2 BREAKING DOWN A METABOLIC BARRIER FOR DIRECT NEURONAL REPROGRAMMING OF GLIAL CELLS S. Gascón – Ludwig-Maximilians-Universität München 10-3 RECONSTRUCT DESTRUCTED BRAIN CIRCUIT VIA GLIA-TO-NEURON CONVERSION G. Chen – Penn State University 10-4 ENGINEERING NEUROGENESIS IN THE POSTNATAL BRAIN B. Berninger – King’s College London 10-5 GLIA-SCHMIA: REPLACING LOST NEURONS FOR STROKE REPAIR C. Morshead – University of Toronto 10-6 ADDRESSING CONCERNS OF NEUROLOGICAL CHIMERAS IN HUMAN-ANIMAL BLASTOCYST COMPLEMENTATION W. Low – University of Minnesota

Precision Medicine in Neurodegenerative Disease & Emerging Neurotechnologies 10:00 am – 12:05 pm Session Chairs: Kevin Nash & Corinna Burger

11-1 MJFF TOOLS PROGRAM N. Polinski – Michael J. Fox Foundation 11-2 PRECISION MEDICINE APPROACH TO IDENTIFY DRUG TREATMENTS FOR ALS USING WHOLE GENOME SEQUENCING AND PATIENT DERIVED STEM CELLS R. Bowser – Gregory W. Fulton ALS Research Center 11-3 THERAPEUTIC EFFORTS AROUND A SINGLE PATIENTS DISEASE - ALS N. Boulis – Emory University 11-4 THE ROLE OF rs6265 BDNF SNP ON FUNCTIONAL REMODELING OF THE PARKINSONIAN STRIATUM FOLLOWING DOPAMINE NEURON GRAFTING IN CRISPR KNOCK-IN RATS. K. Steece-Collier – Michigan State University 11-5 THE EFFECT OF hMSCS ON CELL DEATH PATHWAYS IN THE SPINAL CORD OF SOD1G93A RATS P. Jendelova – Czech Academy of Sciences 11-6 HUMAN-ON-A-CHIP SYSTEMS FOR USE IN PRE-CLINICAL DRUG DISCOVERY FOR ALZHEIMER’S DISEASE J.J. Hickman – University of Central Florida 11-7 ASSESSING IN VIVO NEURONAL REPROGRAMMING BY AUTOMATED RESONANCESCANNED CONFOCAL STEREOLOGY D. Peterson – Rosalind Franklin University

12: Professional Development Workshop Series II Methods to Promote Data Reproducibility in Laboratory Research 1:30 pm â&#x20AC;&#x201C; 3:00 pm

*Attend both workshops (4/26 & 4/27) to receive certificate

Rising Star Research Top-Ranked Travel Award Winners 3:15 pm – 4:15 pm Session Chairs: Ivette Sandoval & Peter Deng

13-1 VIRAL OVEREXPRESSION OF Nurr1 INDUCES SEVERE LID IN RESISTANT RATS AND PROMOTES DYSKINESIA-LIKE NEURONAL SIGNALING R.C. Sellnow, Travel award winner – Michigan State University 13-2 ROLE OF T CELLS IN ALPHA-SYNUCLEIN MODEL OF PARKINSON'S DISEASE M.S. Subbarayan, Travel award winner – University of South Florida 13-3 SEROTONERGIC HYPERINNERVATION IN NON-MOTOR CIRCUITS IN THE PARKINSONIAN RAT M. Davidsson, Travel award winner – Michigan State University 13-4 (-)-PHENSERINE AMELIORATES CONTUSION VOLUME LOSS, NEUROINFLAMMATION, AND BEHAVIORAL IMPAIRMENTS INDUCED BY TRAUMATIC BRAIN INJURY IN MOUSE S-C. Hsueh, Travel award winner – Case Western Reserve University

Roy Bakay Memorial Lecture 4:30 pm – 5:30 pm Introduction: Jeffrey Kordower 14-1 GENE NETWORKS REVEAL NEW THERAPEUTIC TARGETS FOR NEURODEGENERATIVE DISEASES Howard Federoff, MD, PhD, University of California, Irvine

ASNTR Memorial Award Presentation 5:30 pm – 5:45 pm Paul Sanberg

ASNTR Business Meeting 5:45 pm – 6:00 pm Fredric Manfredsson

All members and nonmembers are strongly encouraged to attend this meeting to welcome new ASNTR officers and to become actively involved in the future direction of the society.

Make plans now to join us next year!

April 23-25th

2020

27th annual meeting of the American Society for Neural Therapy and Repair

Sheraton Sand Key Resort Clearwater Beach, FL, USA