52nd International Chemistry Olympiad, Istanbul, TURKEY
Preparatory problems: PRACTICAL
Problem P1. Drug Delivery from a Polymeric Hydrogel System
Chemical structure of paracetamol.
Nowadays, studies in the field of medicine aim to reduce the drug dose to a minimum, extend the dose range, and improve the quality of life by ensuring that the patient is not affected by the side effects of the drug. “Controlled release systems” provide the best response to this goal. Controlled release is a system that can be prepared in membrane or matrix form. Controlled release of a drug from systems such as a hydrogel film or sphere allows the drug to be more effectively introduced into the body. Paracetamol is a drug active substance with analgesic and antipyretic properties. It is one of the most common drugs used to reduce moderate/mild pain and fever. In this problem, you will examine the controlled release of paracetamol active substance from a hydrogel polymer system. Chemicals Substance
Name
State
Paracetamol
Solid
GHS Hazard Statements H302, H315, H317, H319, P280, P301 + P312 + P330, P305 + P351 + P338 170