Delaware Journal of Public Health - Genetics/Genomics

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Delaware Academy of Medicine

Board of Directors: OFFICERS S. John Swanson, M.D. President Lynn Jones, FACHE President-Elect Professor Rita Landgraf Vice President Jeffrey M. Cole, D.D.S., M.B.A. Treasurer Stephen C. Eppes, M.D. Secretary Omar A. Khan, M.D., M.H.S. Immediate Past President Timothy E. Gibbs, M.P.H. Executive Director, Ex-officio DIRECTORS David M. Bercaw, M.D. Lee P. Dresser, M.D. Eric T. Johnson, M.D. Erin M. Kavanaugh, M.D. Joseph Kelly, D.D.S. Joseph F. Kestner, Jr., M.D. Brian W. Little, M.D., Ph.D. Arun V. Malhotra, M.D. Daniel J. Meara, M.D., D.M.D. Ann Painter, M.S.N., R.N. John P. Piper, M.D. Charmaine Wright, M.D., M.S.H.P. EMERITUS Robert B. Flinn, M.D. Barry S. Kayne, D.D.S.

Delaware Public Health Association

Advisory Council:

Omar Khan, M.D., M.H.S. Chair Timothy E. Gibbs, M.P.H. Executive Director Louis E. Bartoshesky, M.D., M.P.H. Gerard Gallucci, M.D., M.H.S. Richard E. Killingsworth, M.P.H. Erin K. Knight, Ph.D., M.P.H. Melissa K. Melby, Ph.D. Mia A. Papas, Ph.D. Karyl T. Rattay, M.D., M.S. William J. Swiatek, M.A., A.I.C.P.

Delaware Journal of Public Health Timothy E. Gibbs, M.P.H. Publisher Omar Khan, M.D., M.H.S. Editor-in-Chief Louis E. Bartoshesky, M.D., M.P.H. Eric B. Kmiec, Ph.D. Guest Editors Liz Healy, M.P.H. Managing Editor Kate Smith, M.D., M.P.H. Copy Editor Suzanne Fields Image Director ISSN 2639-6378

Delaware Journal of

December 2021

Public Health Volume 7 | Issue 5

A publication of the Delaware Academy of Medicine / Delaware Public Health Association

3 | In This Issue Omar A. Khan, M.D., M.H.S. Timothy E. Gibbs, M.P.H.

32 | Development of Cell Lines for use in COVID-19 Drug Development and Research London McGill, M.S.

4 | Guest Editor Louis E. Bartoshesky, M.D., M.P.H., F.A.C.M.G.

5 | Guest Editor Eric B. Kmiec, Ph.D.

6 | Recent Scientific Breakthroughs Applying CRISPR Gene Editing in Neurological Disorders Mitra Assadi-Khansari, M.D., F.A.A.N. London Pamela McGill, M.S.

10 | Impact of Genetic Testing on Human Health: The Current Landscape and Future for Personalized Medicine

36 | Accelerating the Pace of Newborn Screening Research to Advance Disease Understanding and Improve Health Outcomes: Key Efforts of the Newborn Screening Translational Research Network (NBSTRN) Amy Brower, Ph.D. Kee Chan, Ph.D., M.P.H. Jennifer Taylor, Ph.D. Ross Wiebenga Galata Tona, M.S. Yekaterina Unnikumaran, M.S. LaStephanie Barnes

38 | Life Sciences at Delaware Technical Community College

Vicky L. Funanage, Ph.D.

Mark T. Brainard, Ph.D.

12 | Realities of Pharmacogenomic and Minimizing Misconceptions and Medication Misadventures

40 | Impact of the Access to Genetic Counselor Services Act

Benjamin Duong, Pharm.D.

20 | The Genetic Testing Stewardship Program: A Bridge to Precision Diagnostics for the Non-genetics Medical Provider

Carol Nowlen, M.S. Kendra Flores, M.S., C.G.C.

42 | CRISPR In A Box™ and the Journey Toward Inspiring New Scientists Kristen Pisarcik

64 | Disparities in Delaware Caregiver Beliefs about the COVID-19 Vaccine for their Children Thao-Ly Tam Phan, M.D., M.P.H. Paul T. Enlow, Ph.D. Michael K. Wong Amanda M. Lewis, M.P.H. Anne E. Kazak, Ph.D., A.B.P.P. Jonathan M. Miller, M.D.

72 | Characteristics and Outcomes of SARS-CoV-2 Infection Among Adults Living With HIV In Delaware: The Story of a Syndemic During the First 12 Months of the SARS-CoV-2 Pandemic Adam K Skrzynski, M.D. Brooke L Darmstadter, Pharm.D., A.A.H.I.V.P. Sharon P Miner, A.G.P.C.N.P.-B.C. Keshab Subedi, M.S., M.Sc. Deborah Kahal, M.D., M.P.H., F.A.C.P.

80 | Team Up For Quality Care: The Role of Primary Care Teams in Prevention Of Cardiovascular Disease Cindy Biederman, M.S.N., R.N.

92 | History & Archives: Letter to the Editor Sharon Folkenroth-Hess, M.A.

Morgan Thomas, M.G.C., C.G.C. Louise Amlie-Wolf, M.S., C.G.C. Laura Baker, M.G.C., C.G.C. Karen W. Gripp, M.D., F.A.C.M.G.

44 | An Examination of Seasonal Trends in Delaware Drug Overdoses, 2016-2020

94 | Genetics Lexicon

24 | Molecular Genetic Testing for Kidney Disorders During the COVID-19 Pandemic

Aswini Abraham, M.S. Andrew C. Gray, M.A. Jascha Wagner, Ph.D. Tammy L. Anderson, Ph.D.

96 | Genetics More Information

Susan M. Kirwin Katherine M. Robbins, Ph.D. Kathleen M.B. Vinette Lee Hirata Karen W. Gripp, M.D. Vicky L. Funanage, Ph.D.

COVER

52 | Global Health Matters Sept-Oct 2021

96 | Genetics Resources

97 | Index of Advertisers

Fogarty International Center

The convergence of public health and genetics holds the possibility of improved understanding of the etiology, prevention, and management of complex diseases such as diabetes, dementia, heart disease, cancer including oral cancers, dental diseases, and syndromes.

The Delaware Journal of Public Health (DJPH), first published in 2015, is the official journal of the Delaware Academy of Medicine / Delaware Public Health Association (Academy/DPHA).

only the opinions of the authors and do not necessarily reflect the official policy of the Delaware Public Health Association or the institution with which the author(s) is (are) affiliated, unless so specified.

Submissions: Contributions of original unpublished research, social science analysis, scholarly essays, critical commentaries, departments, and letters to the editor are welcome. Questions? Write ehealy@delamed.org or call Liz Healy at 302-733-3989.

Any report, article, or paper prepared by employees of the U.S. government as part of their official duties is, under Copyright Act, a “work of United States Government” for which copyright protection under Title 17 of the U.S. Code is not available. However, the journal format is copyrighted and pages June not be photocopied, except in limited quantities, or posted online, without permission of the Academy/ DPHA. Copying done for other than personal or internal reference use-such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale- without the expressed permission of the Academy/DPHA is prohibited. Requests for special permission should be sent to ehealy@delamed.org.

Advertising: Please write to ehealy@delamed.org or call 302-733-3989 for other advertising opportunities. Ask about special exhibit packages and sponsorships. Acceptance of advertising by the Journal does not imply endorsement of products. Copyright © 2021 by the Delaware Academy of Medicine / Delaware Public Health Association. Opinions expressed by authors of articles summarized, quoted, or published in full in this journal represent


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