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Contents Now Available and Forthcoming ..........................3 New and Bestselling Textbooks ............................6 Imaging in Medical Diagnosis and Therapy Series ....................................................10 New and Bestselling References ........................16 Page 3
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Biomedical Optics ..............................................20 Image Processing and Informatics ......................22 Also of Interest ....................................................25
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Now Available and Forthcoming New!
Emerging Imaging Technologies in Medicine Edited by
Mark A. Anastasio Washington University, St. Louis, Missouri, USA
Patrick La Riviere
Webb’s Physics of Medical Imaging Second Edition Edited by
M A Flower Institute of Cancer Research/Royal Marsden NHS Foundation Trust, UK
University of Chicago, Illinois, USA
“Possibly the most comprehensive book on the subject currently on the market.”
This book offers a comprehensive survey of emerging medical imaging technologies that show great promise for routine clinical use. Each chapter provides a detailed discussion of the physics/technology and addresses improvements in terms of dose, sensitivity, and specificity, which are limitations of current imaging approaches. The book reflects the major advances in computer hardware, nanofabrication, and laser technology that have led to developments in phasecontrast imaging, photoacoustic imaging, and optical imaging.
Gathering recent developments into one volume, this comprehensive second edition presents the basic physics, modern technology, and up-to-date examples of clinical application across all the modalities of medical imaging. It now covers state-of-the-art detector technology and computer processing used in medical imaging. Along with many new examples and figures, this edition includes new chapters on medical image processing and multimodality imaging.
• Provides an overview of the most important emerging medical imaging technologies, modalities, and clinical applications • Covers tomosynthesis, breast CT, spectral CT, xray phase-contrast imaging, photoacoustic imaging, diffuse optical tomography, and acoustic imaging • Presents an overview of the modality, a summary of clinical potential, and a detailed discussion of the physics and technology • Emphasizes a clear understanding of the fundamentals, with a focus on hardware developments • Discusses multimodality imaging, including PET/MRI, diffuse optical tomography/MRI, and photoacoustic tomography/diffuse optical tomography • Explores three-dimensional microscopy, such as photoacoustic microscopy, optical coherence tomography, and Fourier transform infrared spectroscopy
Selected Contents: Advancements in Absorption-Based X-Ray Imaging. X-Ray Phase-Contrast Imaging. Photoacoustic Imaging and Tomography. Diffuse Optical Imaging. Advances in Acoustical Imaging. Multimodality Imaging. Recent Advancements in ThreeDimensional Microscopy.
—Sandro Olivo, University College London
• Presents the essential physics of medical imaging • Covers each imaging modality in detail, eliminating the need to consult specialized texts • Provides many examples of clinical applications of medical imaging • Includes contributions from leading researchers and clinical scientists • Contains more than 400 high-quality figures, with some in color
Selected Contents: In the Beginning: The Origins of Medical Imaging. Diagnostic Radiology with X-Rays. X-Ray Transmission Computed Tomography. Clinical Applications of X-Ray Computed Tomography in Radiotherapy Planning. Radioisotope Imaging. Diagnostic Ultrasound. Spatially Localised Magnetic Resonance. Physical Aspects of Infrared Imaging. Imaging of Tissue Electrical Impedance. Optical Imaging. Mathematics of Image Formation and Image Processing. Medical Image Processing. Perception and Interpretation of Images. Computer Requirements of Imaging Systems. Multimodality Imaging. Epilogue. Index. Catalog no. IP743, June 2012, 864 pp. ISBN: 978-0-7503-0573-0, $89.95 / £49.99 Also available as an eBook
Catalog no. K13780, December 2012, 361 pp. ISBN: 978-1-4398-8041-8, $169.95 / £108.00 Also available as an eBook
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Now Available and Forthcoming New!
Coming soon!
Monte Carlo Techniques in Radiation Therapy
Handbook of Photomedicine
Edited by
Joao Seco Massachusetts General Hospital, Boston, USA
Frank Verhaegen Maastro Clinic, Maastricht, Netherlands
This book explores the use of Monte Carlo methods for modeling various features of internal and external radiation sources. It addresses applications of the Monte Carlo particle transport simulation technique in radiation therapy, mainly focusing on external beam radiotherapy and brachytherapy. Along with presenting mathematical and technical aspects of the methods, the book discusses the modeling of medical linacs and other irradiation devices; issues specific to electron, photon, and proton ion beams and brachytherapy; and the optimization of treatment planning, radiation dosimetry, and quality assurance. • Provides a broad practical guide to the rapidly growing field of Monte Carlo simulations used in medical physics in radiotherapy • Includes the mathematical and technical background required for understanding Monte Carlo simulations and variance reduction techniques • Covers real medical applications of Monte Carlo methods in proton/light ion therapeutics, beam models, quality assurance, radiation dosimetry, and patient dose calculation • Incorporates examples to help illustrate key points
Selected Contents: Monte Carlo Fundamentals: History of Monte Carlo. Basics of Monte Carlo Simulations. Variance Reduction Techniques. Overview of Monte Carlo Codes. Application of Monte Carlo Techniques in Radiation Therapy: Applications of Monte Carlo to Radiation Dosimetry. Monte Carlo Modeling of External Photon Beams in Radiotherapy. Monte Carlo Modeling of External Electron Beams in Radiotherapy. Dynamic Beam Delivery and 4D Monte Carlo. … Index. Catalog no. K14687, March 2013, 342 pp. ISBN: 978-1-4665-0792-0, $149.95 / £95.00 Also available as an eBook
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Edited by
Michael R. Hamblin Harvard Medical School, Boston, Massachusetts, USA
Ying-Ying Huang Wellman Center for Photomedicine, Boston, Massachusetts, USA
This handbook thoroughly covers both therapeutic applications of light and diseases/conditions caused by light exposure. It also discusses the underlying cellular mechanisms and molecular synthesis of photosensitizer dyes used in phototherapy. An introductory section provides the necessary background for newcomers to the field, briefly tracing the history of the field and summarizing fundamental principles. Each subsequent section addresses a major subject of the field, including UV/PVA phototherapy, photodynamic therapy, laser surgery and medicine, and low-level laser/light therapy. Along with many examples, the book offers expert views on the state of the art and challenges in photomedicine. • Supplies a complete overview of the state of the art in photomedicine, from basic science to translational research and clinical treatment • Examines the diseases and conditions associated with UV/PVA phototherapy, photodynamic therapy, laser surgery and medicine, and low-level laser/light therapy • Takes an interdisciplinary approach by integrating knowledge and techniques from chemistry, physics, engineering, the biological sciences, and clinical medicine • Addresses photocarcinogenesis, photodermatoses, photoallergies, and photoaging • Explores timely topics related sunscreens and climate change-associated UV exposure
Selected Contents: History and Fundamentals. Diseases Caused by Light. Ultraviolet Phototherapy. Photodynamic Therapy (PDT). Low-Level Light Therapy (LLLT). Surgical Laser Therapy. Other Phototherapy and Future Outlook. Catalog no. K13978, October 2013, c. 904 pp. ISBN: 978-1-4398-8469-0, $199.95 / £127.00 Also available as an eBook
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Now Available and Forthcoming Coming soon!
Image Processing in Radiation Therapy
New!
Edited by
Pediatric Radiotherapy Planning and Treatment
Kristy K. Brock
Arthur J. Olch
University of Michigan, Ann Arbor, USA
Children’s Hospital Los Angeles, California, USA
Drawing on expert assessments and practical references, this book provides complete descriptions of the techniques involved in medical image processing. Chapters cover deformable registration, segmentation, and image reconstruction, along with the integration of these practices into the radiation therapy environment.
This practical guide covers every common diagnosis and disease site for infants through to teenagers. It presents clinical background information on pediatric cancers and a detailed discussion of treatment planning guidelines and methods. The author provides an overview of pediatric cancer and addresses specific issues that make treating children a challenge. The book also describes clinical trial guidelines and includes examples, CT scans, MRI images, tables, and figures.
The book’s four sections provide an overview of image segmentation and reconstruction techniques using image processing across all modalities as well as applications of these approaches in radiation therapy. The book also addresses the applications of registration, segmentation, and image reconstruction for radiation therapy, including adaptive radiotherapy, monitoring and tracking of treatment delivery, quantifying accuracy, and visualizing results. • Offers a complete overview of image registration, segmentation, and reconstruction techniques as well as their effectiveness and applicability in a radiation therapy context • Covers the underlying physics and image processing associated with the techniques • Includes critical evaluations of parametric and nonparametric image registration techniques and their applications in radiation therapy processes • Covers image segmentation techniques, from atlas-based to level set and registration-based techniques across modalities • Discusses adaptive radiotherapy, monitoring and tracking of treatment delivery, quantifying accuracy, and visualizing results
Selected Contents: Image Processing in Radiotherapy Applications. Registration. Segmentation. Advanced Imaging Techniques. Catalog no. K11476, August 2013, c. 312 pp. ISBN: 978-1-4398-3017-8, $129.95 / £82.00 Also available as an eBook
• Offers a concise and easy-to-use guide for treating pediatric cancers using radiation, with an emphasis on how to create and optimize treatment plans and accurate execution • Provides a much-needed bridge between clinical material specific to pediatrics and technical material specific to adults • Covers both IMRT and 3D conformal methods • Includes real example cases with anatomical drawings and CT/MR images as well as figures that show target and organs-at-risk volumes, beam arrangements, and dosimetry • Describes the use of advanced technologies, including proton beam therapy, cyberknife, and image-guided radiotherapy • Discusses special considerations for pediatric care, immobilization devices, and tips for undertaking clinical trials
Selected Contents: Section I Pediatric Cancers and Challenges for Radiotherapy: Overview of Childhood Cancer: Incidence, Survival, and Late Effects. Challenges of Treating Children with Radiation Therapy. Section II Guide to Treatment Planning and Dose Delivery: Leukemia. Tumors of the Central Nervous System. Hodgkin Lymphoma. Neuroblastoma. Wilms’ Tumor. Soft Tissue Tumors. Bone Sarcomas. Retinoblastoma. Catalog no. 85093, April 2013, c. 376 pp. ISBN: 978-1-4200-8509-9, $149.95 / £95.00 Also available as an eBook
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New and Bestselling Textbooks Coming soon!
Clark’s Essential Physics in Imaging for Radiographers Ken Holmes, Phil Harris, and Marcus Elkington
Measurement and Detection of Radiation Third Edition Nicholas Tsoulfanidis University of Nevada, Reno, USA
Sheldon Landsberger University of Texas at Austin, USA
An invaluable tool for students, assistant practitioners, and radiographers, this easy-to-understand, handy book provides an accessible guide to the subject, with diagrams and photographs to support the text. The text opens with chapters giving an overview of image production, basic mathematics, and physics relevant to medical imaging, followed by detailed chapters on the physics relevant to producing diagnostic images using x-rays. Each chapter has clear learning objectives and a series of MCQs to test these learning outcomes.
“… a very good textbook, providing a solid introduction to radiation detection and measurement for upper-level undergraduate and first-year graduate students in the field of nuclear science and engineering.”
• Offers a practical guide for the study of physics in imaging for radiographers
“This book is an excellent review of nuclear detection systems. The updated text is particularly timely with regard to the current zeitgeist for homeland security, nuclear non-proliferation, and nuclear security.”
• Presents clear explanations supplemented with many diagrams and photographs • Enables readers to understand fundamental definitions of physics and how these are applied to radiography
—Medical Physics, July 2012
“… a good background reference [for] those interested in a refresher course in the physics underlying detection. …” —Olivier Gayou, Doody’s Listings and Reviews, August 2011
—Steven Biegalski, University of Texas at Austin
• Makes a difficult subject easy by offering learning objectives at the beginning of each chapter as well as MCQs and challenging questions to test learning outcomes at the end of each chapter
Continuing in the tradition of its bestselling predecessors, this third edition illustrates the fundamentals of nuclear interactions and radiation detection with a multitude of examples and problems. This edition includes a new chapter on recent applications of radiation detection, updated topics, many new references, and a completely updated bibliography.
Selected Contents:
Selected Contents:
Overview of Image Production. Mathematics for Medical Imaging. Physics for Medical Imaging. XRays, X-Ray Circuit, and X-Ray Tube. X-Ray Interactions. Principles of Radiation Detection and Image Formation. Image Quality. Radiation Dose and Exposure Indicators. Image Display and Manipulation in Medical Imaging. Radiation Protection and Safety. Risk–Benefit.
Introduction to Radiation Measurements. Statistical Errors of Radiation Counting. Review of Atomic and Nuclear Physics. Energy Loss and Penetration of Radiation through Matter. Gas-Filled Detectors. Scintillation Detectors. Semiconductor Detectors. Relative and Absolute Measurements. Introduction to Spectroscopy. Electronics. Data Analysis Methods. Photon (Gamma-Ray and X-Ray) Spectroscopy. Charged-Particle Spectroscopy. Neutron Detection and Spectroscopy. Activation Analysis. Health Physics Fundamentals. Applications of Radiation Detection. Appendices. Index.
Catalog no. K18088, June 2013, 320 pp. Soft Cover, ISBN: 978-1-4441-4561-8 $31.95 / £19.99
Catalog no. 91859, December 2010, 518 pp. ISBN: 978-1-4200-9185-4, $145.95 / £93.00 Also available as an eBook
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New and Bestselling Textbooks
Applied Medical Image Processing A Basic Course Wolfgang Birkfellner Medical University of Vienna, Austria
“The topics covered are clearly explained … an ideal text for anyone who is new to medical image processing. … This text is likely to be of interest to students starting work in medical image processing and would be a useful library text for hospital departments offering training in medical imaging.” —Sarah Cade, Scope, December 2011
“The CD adds substantial value to the text and serves as an excellent guide to practice the information covered in the text. … Several books on image processing have been published recently, and this book takes a backseat to none of them. … Students who take a course where this book is used as the course text will be fortunate indeed.” —William Hendee, Medical Physics, December 2010
“[A]n outstanding work that will be of interest to virtually all biomedical engineers. The text is easy to follow, supposing only that the reader has a modest knowledge of linear algebra, basic engineering principles, and computer programming. … Relevant medical images used for processing compliment many of the concepts discussed. … The text and images refer to several MATLAB®-based programming examples that are provided at the end of each chapter. … The book is enjoyable to read, and students and professionals will not be bored when doing so. …” —Edward J. Ciaccio, BioMedical Engineering OnLine, 2011
Selected Contents: A Few Basics of Medical Image Sources. Image Representation. Operations in Intensity Space. Segmentation. Filtering and Transformations. Spatial Transforms. Rendering, Visualization, and Surface Models. Registration. Volume Reconstruction. Appendix. Glossary. Index. Catalog no. K11176, September 2010, 403 pp. ISBN: 978-1-4398-2444-3, $76.95 / £48.99 Also available as an eBook
Physics for Diagnostic Radiology Third Edition P.P. Dendy Addenbrookes NHS Trust, Cambridge, UK
B. Heaton Aberdeen Radiation Protection Services, UK
“… written in a clear and concise style, supported by excellent illustrations. The textbook describes recent state-of-the-art advances in medical imaging in a way radiologists, radiographers and medical physicists will find easy to understand. It is internationally recognised as one of the key textbooks in its field.” —Keith Faulkner, North East Strategic Health Authority, UK
• Explains the underlying physical principles of imaging techniques • Includes new chapters on PET and PACS • Offers new material on digital receptors, radiation doses and risks to patients, and special radiographic techniques • Points out the similarities of concepts across different modalities • Follows the guidelines issued by the European Federation of Organisations in Medical Physics for training in diagnostic radiology • Contains exercises and multiple choice questions for readers to assess their understanding of the basic principles • Includes extensive cross-referencing, text references, and recommendations for further reading
Selected Contents: Fundamentals of Radiation Physics and Radioactivity. Production of X-Rays. Interaction of X-Rays and Gamma Rays with Matter. Radiation Measurement. The Image Receptor. The Radiological Image. Assessment of Image Quality and Optimisation. Tomographic Imaging with X-Rays. Special Radiographic Techniques. Diagnostic Imaging with Radioactive Materials. Positron Emission Tomographic Imaging (PET). Radiobiology and Generic Radiation Risks. Radiation Doses and Risks to Patients. Practical Radiation Protection and Legislation. Diagnostic Ultrasound. Magnetic Resonance Imaging. Digital Image Storage and Handling. Multiple Choice Questions. Index. Catalog no. 83155, August 2011, 720 pp. ISBN: 978-1-4200-8315-6, $79.95 / £49.99 Also available as an eBook
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New and Bestselling Textbooks Introduction to Physics in Modern Medicine
Nuclear Medicine Physics
Second Edition
Edited by
Suzanne Amador Kane
Joao Jose De Lima
Haverford College, Pennsylvania, USA
IBILI Biophysics Institute, Coimbra, Portugal
“… textbooks introducing this topic to students from non-scientific backgrounds need to present the fundamental theory in a manner that is easily grasped yet sufficiently in depth to enable the reader to appreciate its application to real problems. Introduction to Physics in Modern Medicine manages to tread this fine line admirably. … To make this second edition up to date, the author describes a number of recent advances … the contents are thoroughly grounded in well-explained practical examples. … [a] well-researched book that renders complex subject matter thoroughly understandable and enjoyable.”
“The data contained here will no doubt prove vital to researchers in multiple disciplines (physics, nuclear medicine, oncology) looking for ways to expand and upgrade patient care, specifically, oncologists charged with diagnosing and treating various forms of cancer will immediately benefit from learning how nuclear imaging techniques can enhance the patient experience in the clinical setting.”
—Contemporary Physics, 2011
Fully updated, this second edition builds on the bestselling original to provide medical and physics students with an exploration of the physics-related applications found in state-of-the-art medical centers. Requiring very little physics, biology, or chemistry and keeping mathematics to a minimum, the applicationsdedicated chapters adhere to simple and self-contained qualitative explanations that make use of examples and illustrations. With an enhanced emphasis on digital imaging and computers in medicine, this edition gives readers a fundamental understanding of state-of-the-art medical physics as well as the advances, technologies, and practical applications of digital imaging. The text includes case studies, worked examples, and exercises. Supporting material is available on the author’s website.
—The Electric Review, January 2011
Edited by a renowned international expert in the field, this work explores the physics behind the theoretical foundation and applications of nuclear medicine. It covers important physical aspects of the methods and instruments involved in modern nuclear medicine, along with related biological topics. The book discusses the production of radioisotopes and radiopharmaceuticals, positron physics and positron applications in medicine and biology, and modern radiation detectors and measuring methods. It also explores systems in nuclear medicine, imaging methodologies, dosimetry, and the biological effects of radiation. • Discusses topics useful in nuclear medicine R&D and clinical applications • Covers subjects not frequently discussed in nuclear medicine books, such as accelerators and positron physics • Describes the production of radioisotopes and the biological effects of radiation • Presents novel physical approaches relating to radiopharmaceuticals and their use
Selected Contents: Introduction and Overview. Telescopes for Inner Space. Lasers in Medicine. Seeing with Sound. X-Ray Vision. Images from Radioactivity. Radiation Therapy and Radiation Safety in Medicine. Magnetic Resonance Imaging. Catalog no. C9438, April 2009, 448 pp. Soft Cover, ISBN: 978-1-58488-943-4 $62.95 / £39.99 Also available as an eBook
Selected Contents: Introduction. Radioisotopes and Radiopharmaceuticals Production. Positron Physics: Applications in Medicine and Biology. Modern Radiation Detectors and Measuring Methods. Systems in Nuclear Medicine. Imaging Methodologies. Dosimetry and Biological Effects of Radiation. Index. Catalog no. C7958, November 2010, 524 pp. ISBN: 978-1-58488-795-9, $167.95 / £107.00 Also available as an eBook
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New and Bestselling Textbooks Physiology, Biophysics and Biomedical Engineering Edited by
Andrew W. Wood Swinburne University of Technology, Hawthorn, Victoria, Australia
Showing how biophysics and biomedical engineering have advanced modern medicine, this text provides a multidisciplinary understanding of biological phenomena and the instrumentation for monitoring these phenomena. It explores the application of physics and engineering methods to medicine and biology, including the use of nanotechnology in biomedical engineering. • Offers a multidisciplinary approach to human biological systems • Highlights the application of physics and engineering methods to medicine and biology • Gives readers a solid basis for understanding the physiological processes in the human body • Draws on the classroom material of experienced lecturers
Fundamentals of MRI An Interactive Learning Approach Elizabeth Berry Elizabeth Berry Ltd, Leeds, UK
Andrew J. Bulpitt University of Leeds, UK
“This interactive book with CD by Berry and Bulpitt provides an easy-to-follow, step-by-step process to efficiently assimilate and develop an understanding of the fundamentals of MRI. … The online teaching methods and exercises are both intuitive and informative. This will be an invaluable learning tool and resource for those interested in grappling with the complexities of MRI. I would highly recommend this interactive book to those wanting an understanding of MRI.” —Vincent Khoo, Royal Marsden Hospital, London
“The best text I have seen for students who are preparing for an exam on MRI physics and for self-study.” —Larry Zeng, University of Utah
Catalog no. C9012, December 2008, 320 pp. ISBN: 978-1-58488-901-4, $67.95 / £43.99
• Incorporates a range of numerical problems with worked solutions • Provides MATLAB® code for the advanced mathematical analysis of physiological and clinical monitoring systems
Selected Contents: INTRODUCTION. MAINLY MOLECULES: Molecular Biophysics. Membrane Biophysics. Excitability and Synapses. Skeletal Muscle Biophysics. HEART AND CIRCULATION: Cardiac Biophysics. Rheology of Blood. The Vascular System: Blood Flow Patterns in Various Parts of the Circulation. Cardiovascular System Monitoring. LUNGS, KIDNEYS, AND SPECIAL MONITORING: Respiratory Biophysics. Renal Biophysics and Dialysis. Cardiopulmonary Perfusion and Advanced Surgical Techniques. THE CENTRAL NERVOUS SYSTEM: Organization of the Human Central Nervous System. The Biophysics of Sensation—General. Vision. Audition and Vestibular Sense. Chemical Senses. SYSTEMS AND SIGNALS: Physiological Signal Processing. Bioelectrical Signals: The Electroencephalogram. Magnetic Stimulation and Biomagnetic Signals. Medical Imaging. Microscopy and Biophotonics. SYSTEMS INTEGRATION: Physiological Modeling. Biomechanics and Biomaterials. Biosensors and Emerging Technologies. Answers to Questions. Index. Catalog no. C6513, February 2012, 782 pp. ISBN: 978-1-4200-6513-8, $99.95 / £49.99 Also available as an eBook
A Practical Approach to Medical Image Processing Elizabeth Berry Catalog no. C8245 December 2007, 304 pp. ISBN: 978-1-58488-824-6 $92.95 / £59.99
Biomolecular Action of Ionizing Radiation Shirley Lehnert Montreal General Hospital/McGill University, Quebec, Canada
Catalog no. IP164 October 2007, 560 pp. Soft Cover, ISBN: 978-0-7503-0824-3 $97.95 / £62.99 Also available as an eBook
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Imaging in Medical Diagnosis and Therapy Series New!
Quantitative MRI in Cancer
Comprehensive Brachytherapy
Edited by
Thomas E. Yankeelov, David R. Pickens, and Ronald R. Price Vanderbilt University, Nashville, Tennessee, USA
“… this book fills a void in the literature in this area. … The text is well written and, in particular, is well organized … The text has abundant mathematic derivations and numerous figures and diagrams (including many pulse sequence diagrams) … the text fulfills the goal of providing a one-volume overview of quantitative oncologic MR imaging. It is ideally suited to physician scientists and medical physicists working to advance research in the field and improve future clinical MR imaging applications.” —Michael Orsi, Radiology, July 2012
“… useful as an introductory text for imaging scientists and physicians who engage in quantitative cancer imaging methodologies with other modalities, such as nuclear medicine. … the greatest strengths of this book are its breadth of subject matter, the uniformly large numbers of citations provided by the chapter authors, and the detailed index.” —Geoffrey Clarke, Medical Physics, March 2012
Physical and Clinical Aspects Edited by
Jack Venselaar, Ali S. Meigooni, Dimos Baltas, and Peter J. Hoskin “This book … addresses the topic of brachytherapy from many vantage points (oncological, physical, and biological) and will satisfy readers from the entire radiotherapy community.” —From the Foreword by Pierre Scalliet
Brachytherapy delivers a highly localized dose to a target region using radionuclides implanted in or very near to the tumor. This book provides a complete overview of the field and covers related delivery modalities, such as electronic brachytherapy. Along with exploring new clinical protocols, it discusses major advances under development, including imaging and robotics, strategies for improved dosimetry, Monte Carlo-based dose calculation, and optimization. The first part of the text offers a detailed understanding of the underlying physics, design, and implementation of the techniques. The second part provides a hands-on guide for practitioners. • Provides essential background information and practical guidelines for quick reference
• Shows how MRI is used today for the diagnosis and therapy monitoring of cancer
• Offers a balanced perspective from experts across the globe
• Discusses qualitative and quantitative aspects of the techniques
• Includes recommendations from major professional organizations
• Presents a detailed treatment of tissue characterization using endogenous and exogenous contrast agents
• Integrates the physics and clinical aspects of the practice
• Covers image processing in cancer • Explores emerging trends in MR characterization, such as radiation therapy planning, molecular and cellular imaging, and hyperpolarized MR
• Presents a complete overview of the design, performance, and management of quality assurance programs • Discusses research areas and future developments
Selected Contents:
Selected Contents: Physical Basis of Magnetic Resonance Imaging. Characterizing Tissue Properties with Endogenous Contrast Mechanisms. Characterizing Tissue Properties with Exogenous Contrast Agents. Image Processing in Cancer. Emerging Trends. Index.
Introduction. Brachytherapy Dosimetry Methods. Brachytherapy Treatment Planning and Imaging. Uncertainties in Clinical Brachytherapy. Clinical Brachytherapy. Developments in Clinical Brachytherapy. Radiation Protection and Quality Management in Brachytherapy.
Catalog no. K11087, September 2011, 338 pp. ISBN: 978-1-4398-2057-5, $139.95 / £89.00 Also available as an eBook
Catalog no. K11997, November 2012, 535 pp. ISBN: 978-1-4398-4498-4, $199.95 / £127.00 Also available as an eBook
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Imaging in Medical Diagnosis and Therapy Series Informatics in Medical Imaging Edited by
Quality and Safety in Radiotherapy
George C. Kagadis
Edited by
University of Patras, Rion, Greece
Todd Pawlicki, Peter Dunscombe, Arno J. Mundt, and Pierre Scalliet
Steve G. Langer Mayo Clinic, Rochester, Minnesota, USA
“… a helpful reference guide for medical physicists, radiologists, and administrative staff seeking additional information on medical imaging informatics. … most chapters are well written and easy to read even for readers without much prior knowledge in medical imaging informatics. … well written by experts in their respective fields and has good coverage. Readers may also obtain a wealth of information in medical imaging informatics from references listed at the end of each chapter … .” —Yu Liu, Medical Physics, March 2012
This book reflects the considerable advances made in recent years, most notably in radiology. It also addresses other specialties, such as pathology, cardiology, dermatology, and surgery. The text discusses basic imaging informatics protocols, PACS, and the electronic medical record. It also details key instrumentation and data mining technologies as well as practical operational issues. • Provides practical coverage of standards used to support the different aspects of information in the health care enterprise • Addresses issues concerning pathology, dermatology, and radiation therapy informatics • Discusses procurement, operations, teleradiology, and ethics in the radiology department • Offers a detailed overview of key technologies, including operating systems, networks, and storage and image compression
Selected Contents: Introduction to Informatics in Healthcare. Standard Protocols in Imaging Informatics. Information Systems in Health Care Informatics. Key Technologies. Operational Issues. Medical Informatics beyond the Radiology Department. Catalog no. K11526, October 2011, 367 pp. ISBN: 978-1-4398-3124-3, $157.95 / £101.00 Also available as an eBook
“… it goes well beyond [QA tests] and tackles quality at the highest levels of management and strategy. Virtually every aspect of quality and safety in radiotherapy is dissected … it serves as an excellent starting point and contains many references for further reading. … an extremely useful first reference for any manager wishing to review their current quality management practices. …” —Keri Owen, Scope, December 2011
“… well written and easy to read. Because of its comprehensive nature, students as well as seasoned radiation therapy professionals will find this book useful. … No one book contains the range of topics covered in this book. … the authors provide a brief review of all these topics with enough detail to convey the salient points needed to understand the fundamentals. Each chapter includes a wealth of references, which readers can use to supplement the material in this book. This is an important reference on critically important topics.” —Arthur Olch, Doody’s Review Service, June 2011
• Presents a global view of modern quality techniques that encourage improved patient care and safety • Discusses both process- and people-specific approaches to quality monitoring and improvement • Includes examples that highlight the use of modem quality techniques from manufacturing and engineering • Emphasizes real-world scenarios that offer guidelines for setting up QA programs and performing QA procedures
Selected Contents: Introduction to Quality Assurance and Quality Management. Medical Quality Assurance in Radiotherapy. Quality of Systems and Processes in Radiotherapy. Patient-Specific Quality Assurance in Radiotherapy. Catalog no. K10241, December 2010, 643 pp. ISBN: 978-1-4398-0436-0, $145.95 / £93.00 Also available as an eBook
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Imaging in Medical Diagnosis and Therapy Series Adaptive Motion Compensation in Radiotherapy
Adaptive Radiation Therapy
Edited by
Edited by
Martin J. Murphy
X. Allen Li
Virginia Commonwealth University, Richmond, USA
Medical College of Wisconsin, Milwaukee, USA
This book provides a detailed treatment of online interventional techniques for motion compensation radiotherapy. It explains how adaptive motion intervention is imaging-intensive and relies on near realtime image acquisition and processing. With a focus on the strategy of online motion compensation, the book discusses necessary motion detection methodology, repositioning methodology, and how to interpret and respond to target movement data in real time. It covers methods of detection and correction and then offers examples. It also explores the distinct problems in dose planning and delivery posed by each adaptation technology.
“The breadth of the book is impressive, and the authors of each chapter provide a wealth of up-todate references, making it easy for readers who are interested in exploring certain ART techniques and technologies in more detail … The editor and the authors are to be commended for producing a valuable work on a very dynamic field that offers a chance for meaningful clinical benefits to many patients receiving radiation therapy for a variety of cancer types and clinical indications.”
• Presents the full spectrum of image guidance techniques for medical interventions in the context of critical issues of motion compensation • Pays special attention to the interplay between beam and target movement • Explains problems with dose planning and delivery of various methods
—Moyed Miften, Medical Physics
“The book contains a wealth of useful information ranging from practical workflow issues to directions of future research. I recommend this book for medical physicists and radiation oncologists who are interested in clinical practice and research utilizing advanced imaging and radiation therapy technology.” —James C.H. Chu, Rush University Medical Center
• Discusses fault detection and quality assurance
Selected Contents:
Selected Contents:
PART I TREATMENT PLANNING: Goals of Radiation Therapy. 3D and 4D Morphological Imaging for Radiation Treatment Planning. Biological Imaging for Radiation Treatment Planning. Biomarkers for Early Radiation Response. Inverse Treatment Planning. Biologically Based Models for Treatment Planning. … PART II TREATMENT DELIVERY: IMRT Delivery. CTBased IGRT Technology. Non-CT-Based IGRT. Offline Correction Strategies for Interfraction Variations. Online Correction Strategies for Interfraction Variations. Intrafraction Variations and Management Technologies. Stereotactic Radiation Therapy Delivery. Image-Guided Brachytherapy. Quality Assurance in Adaptive Radiation Therapy. PART II CLINICAL APPLICATIONS: Central Nervous System. Head and Neck. Breast. Lung. Liver. Prostate. Sarcoma.
Introduction. Real-Time Tumor Localization. Theoretical Aspects of Target Detection and Tracking. Respiratory Gating. The CyberKnife® Image-Guided Frameless Radiosurgery System. Fundamentals of Tracking with a LINAC MLC. Couch-Based Target Alignment. Robotic LINAC Tracking Based on Correlation and Prediction. Treatment Planning for Motion Adaptation in Radiation Therapy. Treatment Planning for Motion Management via DMLC Tracking. Real-Time Motion Adaptation in Tomotherapy® using a Binary MLC. Combination of a LINAC with 1.5 T MRI for Real-Time Image-Guided Radiotherapy. The ViewRayTM System. Fault Detection in Image-Based Tracking. Catalog no. K11160, December 2011, 165 pp. ISBN: 978-1-4398-2193-0, $157.95 / £101.00 Also available as an eBook
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Catalog no. K10840, January 2011, 427 pp. ISBN: 978-1-4398-1634-9, $157.95 / £101.00 Also available as an eBook
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Imaging in Medical Diagnosis and Therapy Series New!
Proton and Carbon Ion Therapy Edited by
C.-M. Charlie Ma Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Tony Lomax Paul Scherrer Institute, Villigen PSI, Switzerland
An up-to-date guide to using proton and carbon ion therapy in modern cancer treatment, this book offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and the future outlook of the field. It covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. The book also gives practical guidance on patient setup, target localization, and treatment planning for clinical proton and carbon ion therapy, offering detailed reports on the treatment of various cancers. • Discusses advances in the radiobiology of protons and heavy ions • Describes the latest particle accelerators and particle therapy delivery techniques
Image-Guided Radiation Therapy Edited by
J. Daniel Bourland Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
“Image-Guided Radiation Therapy contains valuable information on the history of image-guided radiation treatment (IGRT), imaging systems, and secondary technologies. It is extensive in the explanation of how such systems are used clinically, and it covers most of the devices offered by manufacturers today. It is truly a remarkable compilation of focused and detailed chapters that span the art of image-guided radiation therapy.” —Michael S. Gossman, Medical Physics, June 2012
• Explains the clinical uses and impact of IGRT technologies on radiation treatment • Offers the research and clinical expertise of the inventors of IGRT technologies and early users of imaging technologies
• Covers modern dosimetry, image guidance, and treatment planning methods for particle therapy
• Describes conventional gantry, ring gantry, and robotic linac systems as well as imaging technologies that use ultrasound, fan-beam CT, cone-beam CT, x-ray, and PET/CT
• Presents recent treatment techniques and outcomes of proton and carbon ion therapy
• Surveys the technology behind real-time monitoring/tracking
Selected Contents:
• Presents clinical applications of head–neck, prostate, lung, brain, and breast cancer treatments
Introduction to Proton and Carbon Ion Therapy. Accelerators for Proton and Ion Therapy. Beam Delivery Systems for Particle Therapy. Requirements for Particle Therapy Facilities. Radiobiology of Proton and Carbon Ion Therapy. Dosimetry for Proton and Carbon Ion Therapy. Image-Guided Proton and Carbon Ion Therapy. Treatment Planning for Scanned Particle Beams. Conformal Proton Therapy. Clinical Experience with Particle Radiotherapy. Future Prospects for Particle Therapy. Index. Catalog no. K10826, October 2012, 250 pp. ISBN: 978-1-4398-1607-3, $129.95 / £82.00 Also available as an eBook
• Discusses future R&D
Selected Contents: Optical and Remote Monitoring IGRT. UltrasoundGuided Radiation Therapy. In-Room CT System for IGRT. Megavoltage Fan-Beam CT IGRT. Kilovoltage Cone-Beam CT Guidance of Radiation Therapy. Megavoltage Cone-Beam IGRT. Kilovoltage X-Ray IMRT and IGRT. Kilovoltage Radiography for Robotic Linac IGRT. Respiratory-Correlated CT. 4D PET/CT in Radiotherapy. On-Board Digital Tomosynthesis: An Emerging New Technology for IGRT. Image Registration and Segmentation in Radiation Therapy. Catalog no. K10143, February 2012, 256 pp. ISBN: 978-1-4398-0273-1, $129.95 / £82.00 Also available as an eBook
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Imaging in Medical Diagnosis and Therapy Series New!
Physics of Thermal Therapy
New!
Fundamentals and Clinical Applications Edited by
Edited by
Mia K. Markey
Eduardo Moros Moffitt Cancer Center, Tampa, Florida, USA
This book covers the basic principles, practical aspects, and clinical applications of thermal therapy. It shows how the use of controlled heat in medicine and biology involves electromagnetics, acoustics, thermodynamics, heat transfer, and imaging sciences. The book discusses challenges in the use of thermal energy on living tissues and explores genetic, cellular, and physiological responses that will help in combating cancer. It also highlights recent advances, including the treatment of solid tumors using image-guided thermal therapy, microbubbles, nanoparticles, and other cutting-edge techniques.
Selected Contents: Foundations of Thermal Therapy Physics: Fundamentals of Bioheat Transfer. Thermal Dose Models: Irreversible Alterations in Tissues. Practical Clinical Thermometry. Physics of Electromagnetic Energy Sources. The Physics of Ultrasound Energy Sources. Numerical Modeling for Simulation and Treatment Planning of Thermal Therapy: Ultrasound. Numerical Modeling for Simulation and Treatment Planning of Thermal Therapy. Clinical Thermal Therapy Systems: External Electromagnetic Methods and Devices. Interstitial Electromagnetic Devices for Thermal Ablation. Clinical External Ultrasonic Treatment Devices. Endocavity and Catheter-Based Ultrasound Devices. Physical Aspects of Emerging Technology for Thermal Therapy: Evolving Tools for Navigated Image-Guided Thermal Cancer Therapy. Temperature Imaging Using Ultrasound. Focused Ultrasound Applications for Brain Cancer. Extracorporeal Ultrasound-Guided High-Intensity Focused Ultrasound Ablation for Cancer Patients. Using Hyperthermia to Augment Drug Delivery. Magnetic Nanoparticles for Cancer Therapy. Application of Gold Nanoparticles in Laser Thermal Therapy. Thermochemical Ablation. Catalog no. K12209, December 2012, 375 pp. ISBN: 978-1-4398-4890-6, $149.95 / ÂŁ95.00 Also available as an eBook
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Physics of Mammographic Imaging The University of Texas at Austin, USA
Covering the fundamentals of image formation, interpretation, analysis, and modeling, this volume presents a detailed, state-of-the-art overview of the technical aspects of mammographic imaging and its clinical context. It covers the use of mammographic imaging in the detection, diagnosis, treatment planning, and monitoring of breast cancer. Expert authors give a balanced summary of core topics such as digital mammography, contrast-enhanced mammography, stereomammography, breast tomosynthesis, and breast CT. The book highlights the use of mammographic imaging with complementary breast imaging modalities, such as ultrasound, MRI, and nuclear medicine techniques. It also discusses critical issues that include computer-aided diagnosis, perception, and quality assurance.
Selected Contents: Image Formation: Fundamentals of Digital Mammography. Contrast-Enhanced Digital Mammography. Stereo Mammography. Breast Tomosynthesis. Breast CT. Comparison of Advanced X-Ray Modalities. Image Interpretation: Breast Cancer Detection and Diagnosis. Image-Guided Procedures and Surgical Planning. Displays for Breast Imaging. Perception of Mammographic Images. Image Analysis and Modeling: Physical Breast Phantoms. Digital Phantoms for Breast Imaging. Observer Models for Breast Imaging. Current Status of Computer-Aided Detection of Breast Cancer. Complementary Approaches: Breast Ultrasound. Breast MRI. Nuclear Medicine Imaging of the Breast: History, Clinical Application and Integration, and Future. Future Directions: Breast Elasticity Imaging. Electrical Impedance Imaging and Spectroscopy of the Breast. Optical Imaging of the Breast. Outlook for Computer-Based Decision Support in Breast Cancer Care. Catalog no. K13500, November 2012, 317 pp. ISBN: 978-1-4398-7544-5, $179.95 / ÂŁ114.00 Also available as an eBook
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Imaging in Medical Diagnosis and Therapy Series New!
Cancer Nanotechnology Principles and Applications in Radiation Oncology Edited by
Sang Hyun Cho Georgia Institute of Technology, Atlanta, USA
Sunil Krishnan University of Texas MD Anderson Cancer Center, Houston, USA
Reflecting profound advances in the application of nanotechnology to radiation oncology, this work demonstrates how the unique physicochemical properties of nanoparticles lead to novel strategies for cancer treatment and detection. After an introduction to the first principles of radiation physics and radiation biology, the book discusses the fabrication of nanoparticles, the safety of nanoparticles, and the quantification of nanoparticle accumulation within tissues. It then highlights the computational and experimental techniques that underlie the use of nanoparticles for imaging and treating tumors. The book concludes with discussions on regulatory issues related to human use and a summary of envisioned clinical translation. • Offers a complete overview of the intersection of nanotechnology and radiation oncology • Presents the full spectrum of developments in experimental research, preclinical testing, and potential clinical uses of nanomaterials as enhancers of radiation therapy efficacy
Targeted Molecular Imaging Edited by
Michael J. Welch Washington University, St. Louis, Missouri, USA
William C. Eckelman University of California–San Diego, La Jolla, USA
“This text successfully fulfills its goal by introducing the concepts of molecular imaging agent development and then providing a diverse set of examples of targeted agents. … The strength of this book is its emphasis of case studies that are representative of the various types of translational studies that can be performed using molecular imaging.” —Michael T. Munley, Medical Physics, August 2012
Covering the fundamental concepts of molecular imaging, this book presents state-of-the-art disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery. It includes examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases. The book is a valuable tool for readers involved with targeted molecular imaging, medicinal chemistry, pharmacology, radiology, and medical physics. • Discusses various methods of validating a new targeted probe through • Includes imaging examples of breast cancer, cardiovascular disease, and neurodegenerative diseases
• Describes the basic principles of cancer targeting by nanomaterials
• Describes basic principles, disease models, and applications in pharmacology and pharmacy
• Covers safety and regulatory issues
• Presents in vitro studies, small animal studies, and targeted radiopharmaceuticals
• Explores the most promising approaches, including the use of nanoparticles for radiation response modulation and thermal ablation treatment of tumors
Selected Contents: Basic Principles of Radiation Oncology and Radiosensitization. Synthesis, Safety, and Imaging of Nanomaterials for Cancer Applications. Nanomaterials for Radiation Therapy. Nanomaterials for Hyperthermia and Thermal Therapy. Future Outlook.
Selected Contents: In Vitro Studies. Small Animal Studies. Radiopharmacology and Radiopharmacy. Case Studies on Developing Target Nonnuclear Probes. Case Studies on Developing Targeted Radiotracers. Catalog no. K11953, February 2012, 388 pp. ISBN: 978-1-4398-4195-2, $169.95 / £108.00 Also available as an eBook
Catalog no. K13683, January 2013, 284 pp. ISBN: 978-1-4398-7875-0, $169.95 / £108.00 Also available as an eBook
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15
New and Bestselling References New!
Monte Carlo Calculations in Nuclear Medicine
Proton Therapy Physics Edited by
Harald Paganetti Massachusetts General Hospital and Harvard Medical School, Boston, USA
This practical guide goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. Along with exploring QA issues and biological considerations, it collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. • Covers all delivery methods of proton therapy, including beam scanning and passive scattering • Discusses clinical aspects, such as treatment planning and QA • Explores such research topics as biological treatment planning • Offers insight on the past, present, and future of proton therapy from a physics perspective • Includes references for further reading
Selected Contents: Proton Therapy: History and Rationale. Physics of Protons Stopping in Matter. Proton Accelerators. Characteristics of Clinical Proton Beams. Beam Delivery Using Passive Scattering. Particle Beam Scanning. Dosimetry. Quality Assurance and Commissioning. Monte Carlo Simulations. Physics of Treatment Planning for Single-Field Uniform Dose. Physics of Treatment Planning Using Scanned Beams. Dose Calculation Algorithms. Precision and Uncertainties in Proton Therapy for Nonmoving Targets. Precision and Uncertainties in Proton Therapy for Moving Targets. Treatment-Planning Optimization. In Vivo Dose Verification. Basic Aspects of Shielding. Late Effects from Scattered and Secondary Radiation. The Physics of Proton Biology. Fully Exploiting the Benefits of Protons: Using Risk Models for Normal Tissue Complications in Treatment Optimization. Index. Catalog no. K11646, December 2011, 704 pp. ISBN: 978-1-4398-3644-6, $139.95 / £89.00 Also available as an eBook
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Second Edition Applications in Diagnostic Imaging Edited by
Michael Ljungberg, Sven-Erik Strand, and Michael A. King This book covers the applications of Monte Carlo calculations in nuclear medicine and critically reviews them from a diagnostic perspective. New chapters in this edition cover codes and applications in pre-clinical PET and SPECT. The book explains how Monte Carlo methods and software packages can be applied to evaluate scatter in SPECT and PET imaging, collimation, and image deterioration. • Provides a guide for researchers developing methods to improve image resolution • Describes various computer programs and critically reviews their areas of application • Demonstrates how Monte Carlo techniques can be used to simulate complex imaging systems • Includes five new chapters that cover new codes and applications in areas such as pre-clinical PET and SPECT systems
Selected Contents: Introduction to the Monte Carlo Method. Variance Reduction Techniques. Anthropomorphic Phantoms: Early Developments and Current Advances. The Gamma Camera: Basic Principles. Positron Emission Tomography. The SimSET Program. The SIMIND Monte Carlo Program. GATE: A Toolkit for Monte Carlo Simulations in Tomography and Radiation Therapy. The MCNP Monte Carlo Program. The EGS Family of Code Systems. ASIM: An Analytic PET Simulator. Monte Carlo in SPECT Scatter Correction. Monte Carlo in Quantitative 3D PET: Scatter. Design of Molecular Imaging Systems Assisted by the Monte Carlo Methods. Introduction to Task-Based Assessment of Image Quality for Investigators Employing Monte Carlo Simulation of Imaging Systems. Monte Carlo Method Applied in Nuclear Medicine Dosimetry. Catalog no. K11910, November 2012, 357 pp. ISBN: 978-1-4398-4109-9, $129.95 / £82.00 Also available as an eBook
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New and Bestselling References Essentials of Forensic Imaging A Text-Atlas Angela D. Levy Georgetown University Hospital, Washington, D.C., and Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
H. Theodore Harcke, Jr. Armed Forces Institute of Pathology, Washington, D.C., and Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
“The work is very well done and makes a significant contribution to the literature on the topic … . [It] addresses, and is applicable to, the whole range of forensic autopsies. The printing/illustration quality is outstanding.” —Joel Lichtenstein, University of Washington
“The book is unusually well illustrated through correlation of photographs and radiological images of the highest quality. … The book is certain to find extended use in training programs and daily death investigation and documentation.” —William A. Murphy, Jr., University of Texas MD Anderson Cancer Center
“I believe that the book will be useful for practicing forensic pathologists. The numerous examples covering a wide variety of forensic cases … illustrate the value of imaging techniques in medicolegal death investigation.” —John Butts, University of North Carolina at Chapel Hill
This text-atlas provides readers with a foundation for applying modern cross-sectional imaging to forensic autopsy. The book integrates more than 300 color images with basic forensic pathology in a topical format. Following an introduction to basic concepts and imaging techniques, subsequent chapters are organized by cause of death. The presentation is supported by full text explanations that review relevant forensic and radiologic principles.
Selected Contents:
Practical Radiological Anatomy Sarah McWilliams St Thomas’ Hospital, London, UK
Practical Radiological Anatomy is an illustrated and concise revision book for radiology trainees who are learning to interpret all modes of imaging. The essential revision book for doctors training in radiology and preparing for the first FRCR exam, Practical Radiological Anatomy is also of great value to advanced radiology practitioners, nurse practitioners, emergency medicine doctors, and radiographers. • Organizes each chapter by body system, with case studies to illustrate the application of anatomy • Provides indispensable guidelines on how to interpret images • Demonstrates the key features of basic anatomy with many clear images and examples of commonly encountered pitfalls • Matches the current curriculum of the FRCR Part 1 and Part 2A exams • Includes both conventional imaging and cross-sectional CT and MRI anatomy to aid in the preparation for the FRCR 2A modules
Selected Contents: Neuroimaging. Imaging of the Nasopharynx, Face, and Neck. Chest Imaging. Gastrointestinal Imaging I: Oesophagus, Stomach, and Bowel. Gastrointestinal Imaging II: Liver, Spleen, Pancreas, Adrenals, Biliary Tract, and Aorta. Imaging of the Genitourinary tTract. Imaging of the Spine. Imaging of the Upper Limb. Imaging of the Lower Limb. On-Call Top Tips. Catalog no. K17220, January 2011, 416 pp. Soft Cover, ISBN: 978-1-85315-800-1 $63.95 / £39.99
Introduction to Forensic Imaging. Integrating Imaging and Autopsy. Postmortem Change and Decomposition. Gunshot Wounds. Blunt Force Injury. Death from Fire and Burns. Blast Injury. Sharp Force Injury. Death by Drowning and Bodies Found in Water. Suicide. Natural Death. Other Causes of Death. Beyond Standard Autopsy. Catalog no. 91115, December 2010, 282 pp. ISBN: 978-1-4200-9111-3, $167.95 / £107.00 Also available as an eBook
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New and Bestselling References Biosensors and Molecular Technologies for Cancer Diagnostics
Radiopharmaceuticals
Edited by
Introduction to Drug Evaluation and Dose Estimation
Keith E. Herold
Lawerence E. Williams
University of Maryland, College Park, USA
Avraham Rasooly National Cancer Institute, Rockville, and the FDA Center for Devices and Radiological Health, Silver Spring, Maryland, USA
Bridging the gap between research and clinical application, this volume explores the use of biosensors as effective alternatives to the current standard methods in cancer diagnosis and detection. It describes the major aspects involved in detecting and diagnosing cancer as well as the basic elements of biosensors and their applications in detection and diagnostics. • Covers many optical-based biosensors, including surface plasmon resonance, evanescent wave and waveguides, optical imaging, luminescence, and photoacoustic analysis • Discusses several modes of electrochemical biosensors, such as potentiometric and amperometric biosensors • Examines electronic and magnetic technologies for cancer analysis, covering field effect transistors, magnetic resonance, and electric fieldbased biosensors • Explores such novel developments as thermometric sensing and optomechanical cantileverbased technologies • Presents the technology and schematics of the devices, helping nonengineers understand the background of biosensors
Selected Contents: Optical Technologies for Cancer Detection and Diagnostics: Surface Plasmon Resonance. Optical Technologies for Cancer Detection and Diagnostics: Evanescent Wave and Waveguide Biosensors. Optical Technologies for Cancer Detection and Diagnostics: Spectrometry for Cancer Analysis. Optical Technologies for Cancer Detection and Diagnostics: Optical Imaging for Cancer Analysis. Optical Technologies for Cancer Detection and Diagnostics: Fluorescence, Luminescence, Refractive Index Detection Technologies. Optical Technologies for Cancer Detection and Diagnostics: Photoacoustic for Cancer Analysis. Electrochemical Biosensors. Electronic and Magnetic Technologies for Cancer Analysis. Thermometric Sensing. Cantilever-Based Technology. Index. Catalog no. K11937, May 2012, 844 pp. ISBN: 978-1-4398-4165-5, $169.95 / £108.00 Also available as an eBook
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City of Hope National Medical Center, Duarte, California, USA
“This high-quality hardcover volume is a textbook providing an exposition … on the development and evaluation of antibody-based and other targeted radionuclide therapies … unique in the targeted radionuclide therapy literature.” —Medical Physics, May 2012
“The book covers a very important topic and fills a gap not covered by others. I believe that it will be a very valuable in our education of Ph.D. students and also very valuable for researchers in this area. I will recommend the book to my colleagues.” —Sven-Erik Strand, University of Lund
“The book is written in a very clear style, and is accessible not only to physicists, but to any professional involved in radiopharmaceutical development and clinical or preclinical experiments. … Through 30 years of experience, Prof. Williams shares with us ideas, caveats, and hints applicable to the domain. In the acknowledgements, he indicates his will to ‘put some chips back in the pot.’ This is exactly how I receive this book: a senior scientist in our field is sharing his experience—and I dare say his wisdom— with us. This atypical book is going to be an essential part of my library.” —Manuel Bardies, INSERM
Selected Contents: Tumor Targeting and a Problem of Plenty. Preclinical Development of Radiopharmaceuticals and Planning of Clinical Trials. Selection of Radiopharmaceuticals for Clinical Trials. Absorbed Dose Estimation and Measurement. Determination of Activity In Vivo. Modeling and Temporal Integration. Functions Used to Determine Absorbed Dose Given Activity Integrals. Absorbed Dose Estimates without Clinical Correlations. Dose Estimates and Correlations with Laboratory and Clinical Results. Multiple-Modality Therapy of Tumors. Allometry (Of Mice and Men). Summary of Radiopharmaceuticals and Dose Estimation. Index. Catalog no. K10532, December 2010, 326 pp. ISBN: 978-1-4398-1067-5, $145.95 / £93.00 Also available as an eBook
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New and Bestselling References Husband & Reznek’s Imaging in Oncology 3rd Edition
Handbook of Physics in Medicine and Biology
Edited by
Edited by
Janet Husband
Robert Splinter
Royal Marsden Hospital, Sutton, UK
University of North Carolina at Charlotte, USA
Rodney H. Reznek
“The handbook includes hundreds of diagrams, images, and tables, making it a useful tool for both medical physicists/engineers and other medical/biology specialists … includes materials that are rarely combined together, which strengthens its interdisciplinary approach.”
St Bartholomew's Hospital, London, UK
The third edition of this comprehensive, award-winning book addresses all aspects of cancer imaging, from diagnosis to long-term follow up. It is organized into nine clearly defined sections, with the core of the text focusing on the application of imaging in all tumors. The book gives an extensively referenced, evidence-based analysis of the role of imaging in planning treatment. It covers the imaging of metastatic diseases as well as cancer imaging. Experienced professionals also examine the advantages and limitations of all relevant imaging modalities, including ultrasound, CT, MRI, PET/CT, and other nuclear medicine techniques. The book’s color diagrams of the staging systems enable readers to easily understand and memorize these often complex systems. In addition, key points and summaries are provided throughout for quick revision. • Includes a new section on functional imaging • Contains extensive references and over 2,500 images • Presents material from pioneering clinical researchers of CT and MRI in cancer care
Selected Contents: General Principles. Primary Tumor Evaluation and Staging. Hematology Malignancy. Pediatrics. Metastases. Imaging and Treatment. Effects of Treatment on Normal Tissue, The Immunocompromised Host. Functional Imaging. Catalog no. DU5516, December 2009, 1520 pp. ISBN: 978-0-415-45167-3, $785.00 / £500.00 Also available as an eBook
—Physics in Medicine and Biology, 55 (2010)
“… an excellent work by a highly competent team. The book chapters follow logically from the properties of the cell membrane through sensors and electroreception, biomechanics, and fluid dynamics to the recording of bioelectrical signals, bioelectric impedence analysis, x-ray and computed tomography, magnetic resonance imaging, nuclear medicine, and ultrasonic and thermographic imaging … keep this book close at hand and do not hesitate to use it frequently.” —BioMedical Engineering OnLine, 2010
This handbook presents a quantitative physical description of all aspects of cellular and organ performance along with the methods used to measure these functions. Moreover, it covers the physics necessary to understand the theoretical and practical basis for the development of diagnostic and therapeutic tools. It offers readers a foundation in relevant physical principles and technology critical to understanding biological functioning for application to biomedical research and healthcare.
Selected Contents: Anatomical Physics. Physics of Perception. Biomechanics. Electrical Physics. Diagnostic Physics. Physics of Accessory Medicine. Physics of Bioengineering. Catalog no. 75241, April 2010, 548 pp. ISBN: 978-1-4200-7524-3, $167.95 / £107.00 Also available as an eBook
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Biomedical Optics New!
Coherent Raman Scattering Microscopy
Handbook of Biomedical Optics
Edited by
Edited by
Ji-Xin Cheng
David A. Boas, Constantinos Pitris, and Nimmi Ramanujam
Purdue University, West Lafayette, Indiana, USA
Xiaoliang Sunney Xie Harvard University, Cambridge, Massachusetts, USA
Edited by pioneers in the field and with contributions from a distinguished team of experts, this color book explains how CRS can be used to obtain a point-bypoint chemical map of live cells and tissues. It discusses the principles of nonlinear optical spectroscopy and presents the theories of contrast mechanisms pertinent to CRS microscopy. The text then provides important technical aspects of CRS microscopy, including microscope construction, detection schemes, and data analyses. It also covers applications that demonstrate how CRS microscopy has become a valuable tool in biomedicine.
Selected Contents: Theory: Theory of Coherent Raman Scattering. Coherent Raman Scattering under Tightly Focused Conditions. Platforms: Construction of a Coherent Raman Microscope. Stimulated Raman Scattering Microscopy. Femtosecond versus Picosecond Pulses for Coherent Raman Microscopy. Wide-Field CARS Microscopy. Vibrational Spectromicroscopy by Coupling Coherent Raman Imaging with Spontaneous Raman Spectral Analysis. Coherent Control in CARS. Fourier Transform CARS Microscopy. CRS with Alternative Beam Profiles. Vibrational Phase Microscopy. Multiplex CARS Microscopy. Interferometric Multiplex CARS. Photonic Crystal Fiber-Based Broadband CARS Microscopy. Multiplex Stimulated Raman Scattering Microscopy. Applications: Imaging Myelin Sheath Ex Vivo and In Vivo by CARS Microscopy. Imaging Lipid Metabolism in Caenorhabditis elegans and Other Model Organisms. Lipid-Droplet Biology and Obesity-Related Health Risks. White Matter Injury: Cellular-Level Myelin Damage Quantification in Live Animals. CARS Microscopy Study of Liquid Crystals. Live Cell Imaging by Multiplex CARS Microspectroscopy. Coherent Raman Scattering Imaging of Drug Delivery Systems. … Catalog no. K13060, October 2012, 610 pp. ISBN: 978-1-4398-6765-5, $149.95 / £95.00
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“This handbook is a successful attempt to provide as much as possible information to a number of physicists, R&D engineers, clinicians, and scientists who would like to apply contemporary concepts and techniques to solving biomedical diagnostic and therapeutic challenges. It often covers areas that are not conventionally addressed, and is generally thought-provoking and brain-stimulating … an excellent tutorial for students and young investigators … a relevant reference for scientists and also a good teaching tool. … a good balance between introductory knowledge and high-level expertise, without burdening the reader with excessive data. What makes it really unique is its scope. … An additional value is that the book is truly state of the art.” —Boris Gramatikov, BioMedical Engineering OnLine, February 2012
“… highly recommend it. It provides an in-depth review and overall treatment covering most areas of biomedicine from the ground-level foundations of optics to background on photon transport in tissues, theory, and experiments. … a major contribution to the biomedical optics field and will serve as a great resource.” —Journal of Biomedical Optics, December 2011
Taking a broad yet detailed approach, this handbook covers light-based diagnostic methodologies and light-mediated therapeutics as well as concepts and cutting-edge optical methods used in research and practice. Extensively illustrated, the book also discusses the advantages and disadvantages of various techniques.
Selected Contents: Background. Spectroscopy and Spectral Imaging. Tomographic Imaging. Microscopic Imaging. Molecular Probe Development. Phototherapy. Catalog no. 90364, June 2011, 831 pp. ISBN: 978-1-4200-9036-9, $157.95 / £101.00 Also available as an eBook
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Biomedical Optics Coming soon!
Handbook of Photonics for Biomedical Science
Advanced Biophotonics Tissue Optical Sectioning Edited by
Edited by
Ruikang K. Wang
Valery V. Tuchin
University of Washington, Seattle, USA
Saratov State University, Russia
“Many of the chapters are written by leaders in their field and thus provide both good foundational descriptions as well as up-to-date accounts of the state of the field. … the book does well throughout: providing a better than skin-deep introduction to a subject, focusing on the core issues within a field and providing references to enable more detailed investigation. … It brings together much of the most important literature into an easily accessible form. … a valuable addition to the collection of researchers, engineers and clinicians alike.” —Peter R.T. Munro, Contemporary Physics, 2011
This handbook analyzes achievements, trends, and perspectives of photonics in its application to biomedicine. World-renowned experts describe advanced biophotonics methods and techniques intensively developed in recent years, enabling readers to become familiar with major, state-of-the-art results in biophotonics science and technology. The text covers finite-difference time-domain simulation, photothermal therapy, nanoparticle photonic technologies, and much more.
Selected Contents: FDTD Simulation of Light Interaction with Cells for Diagnostics and Imaging in Nanobiophotonics. Plasmonic Nanoparticles: Fabrication, Optical Properties, and Biomedical Applications. Transfection by Optical Injection. Advances in Fluorescence Spectroscopy and Imaging. Applications of Optical Tomography in Biomedical Research. Fluorescence Lifetime Imaging and Metrology for Biomedicine. Raman and CARS Microscopy of Cells and Tissues. Resonance Raman Spectroscopy of Human Skin for the In Vivo Detection of Carotenoid Antioxidant Substances. Polarized Light Assessment of Complex Turbid Media Such as Biological Tissues Using Mueller Matrix Decomposition. … Catalog no. K10313, May 2010, 868 pp. ISBN: 978-1-4398-0628-9, $167.95 / £107.00 Also available as an eBook
Valery V. Tuchin Saratov State University, Russia
This reference provides an overview of optical imaging and manipulation technologies in biophotonics, covering both basic and advanced optical imaging techniques. It reviews the principles and fundamentals of bioimaging and molecular imaging/manipulation techniques. It also covers instrumentation, basic algorithms, and data processing methods and explores applications in biotechnology, biomedical engineering, biophysics, medicine, and pharmacology. • Presents a range of imaging and manipulation techniques • Covers new and emerging techniques as well as established technologies • Discusses data processing and instrumentation • Describes advanced imaging technologies based on different approaches for the selection of image-carrying photons and optical tissue sectioning
Selected Contents: Spatial and Temporal Frequency Domain Imaging. Polarization Imaging. Unified Monte Carlo Modeling. Confocal Microscopy. Multiphoton Microscopy and SHG. Optical Coherence Tomography: Theory and Technology Developments. Standards and Traceability for Optical Coherence Tomography. Advances in Doppler OCT. Optical Microangiography. Advances in Blood Flow Imaging. Phase-Sensitive Optical Coherence Tomography for Nanotechnology. Optical Coherence Tomography and Fluorescence Spectroscopy: Optical Slicing Plus Biochemical Probing. Multimodal Tomography Combining Optical Coherence Tomography (OCT) with Fluorescence Laminar Optical Tomography (FLOT). Multiscale Multimodal Imaging of Structure and Function. Quantitative Assessment of Clinical Optical Coherence Tomography Data. Photoacoustic Imaging. Array-Based Photoacoustic Microscopy. Optoacoustic Molecular Imaging: Methods and Applications. … Catalog no. K14253, June 2013, c. 576 pp. ISBN: 978-1-4398-9581-8, $199.95 / £127.00 Also available as an eBook
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Image Processing and Informatics
Practical Biomedical Signal Analysis Using MATLAB® K.J. Blinowska and J. Zygierewicz University of Warsaw, Poland
This book not only covers the current techniques of biomedical signal processing, but it also offers handson guidance on which methods are appropriate for a given task and different types of data. The first several chapters of the text describe signal analysis techniques—including new and advanced methods—in an easy and accessible way. MATLAB® routines are listed when available and freely available software is discussed where appropriate. The final chapter explores the application of the methods to a broad range of biomedical signals, highlighting problems encountered in practice. A unified overview of the field, this book explains how to properly use signal processing techniques for biomedical applications and avoid misinterpretations and pitfalls. It helps readers choose the appropriate method as well as design their own methods. • Provides hands-on guidance for those working in the area of biomedical signal analysis • Covers tools for stationary and nonstationary signals, nonlinear methods of signal analysis, and models and measures for multivariate signals • Compares the advantages and disadvantages of different methods in the context of applications • Refers to MATLAB routines and freely available software found on the Internet • Applies the methods to a variety of electric, magnetic, and acoustic signals
Selected Contents: Introductory Concepts. Single Channel (Univariate) Signal. Multiple Channels (Multivariate) Signals. Application to Biomedical Signals. References. Index. Catalog no. K10605, September 2011, 324 pp. ISBN: 978-1-4398-1202-0, $99.95 / £63.99 Also available as an eBook
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Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications Dzevad Belkic and Karen Belkic Karolinska Institute, Stockholm, Sweden
“… immensely useful as a practical resource handbook to dip into from time to time and to find specific advice on issues faced during the course of work in MR techniques for cancer research. … the best feature of this book is how it positions the very practical area of digital signal processing in the contextual framework of a much more esoteric and fundamental field—that of quantum mechanics. The direct link between quantum-mechanical spectral analysis and rational response functions and the general role of quantum mechanics in signal processing is beautifully brought out in Chapter 2. This chapter alone is worth the price of the book and will especially appeal to a multi-disciplinary audience comprising NMR spectroscopists, atomic and molecular physicists, and physicists who work in the foundations of quantum mechanics.” —Kavita Dorai, Contemporary Physics, January 2013
Selected Contents: Basic Tasks of Signal Processing in Spectroscopy. The Role of Quantum Mechanics in Signal Processing. Harmonic Transients in Time Signals. Signal-Noise Separation via Froissart Doublets. Padé Processing for Magnetic Resonance (MR) Total Shape Spectra from in vivo Free Induction Decays (FIDs). Exact Reconstructions of Spectral Parameters by FPT. Machine Accurate Padé Quantification and Exact Signal-Noise Separation. Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Spectroscopic Imaging (MRSI) in Neuro-Oncology: Achievements and Challenges. Padé Quantification of Malignant and Benign Ovarian MRS Data. Breast Cancer and Non-Malignant Breast Data: Quantification by FPT. Multiplet Resonances in MRS Data from Normal and Cancerous Prostate. General Discussion. Conclusions and Outlooks. Catalog no. K10321, January 2010, 468 pp. ISBN: 978-1-4398-0644-9, $139.95 / £89.00 Also available as an eBook
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Image Processing and Informatics Image Processing with MATLAB® Applications in Medicine and Biology Omer Demirkaya, Musa Hakan Asyali, and Prasanna K. Sahoo This text explains complex, theory-laden topics in image processing through real-world examples and MATLAB® algorithms. The authors emphasize threedimensional processing and analysis as well as statistical and stochastic modeling. They cover the areas of nonlinear diffusion filtering and PDE-based image filtering and highlight applications with images from medicine and biology. • Provides MATLAB algorithms to help scientists and researchers quickly identify the most effective solution method for a particular problem at hand • Enables a diverse set of readers to comprehend the material by striking the right balance between theory and practice • Covers three-dimensional processing and analysis along with statistical and stochastic modeling • Explores nonlinear diffusion filtering and PDEbased image filtering • Addresses relatively advanced topics, including Markov random field-based image segmentation • Includes images from medicine and biology • Contains real-world examples and exercises in every chapter
Selected Contents: Medical Imaging Systems. Fundamental Tools for Image Processing and Analysis. Probability Theory for Stochastic Modeling of Images. Two-Dimensional Fourier Transform. Nonlinear Diffusion Filtering. Intensity-Based Image Segmentation. Image Segmentation by Markov Random Field Modeling. Deformable Models. Image Analysis. Applications. Appendices. Catalog no. 9246, December 2008, 451 pp. ISBN: 978-0-8493-9246-7, $113.95 / £73.99 Also available as an eBook
PACS and Digital Medicine Essential Principles and Modern Practice Yu Liu St. Luke’s Medical Center, Milwaukee, Wisconsin, USA
Jihong Wang University of Texas MD Anderson Cancer Center, Houston, USA
“For someone … looking for a concise summary of PACS, its environs (both departmental and enterprise), components, and support issues—this book would be an excellent choice.” —Steve G. Langer, Medical Physics, October 2012
“… a thorough and practical reference for radiologists, administrators, engineers, and others who might create, manage, or use such a system. …” —SciTech Book News, February 2011
This book presents key principles and practical steps for PACS and EHR implementations and maintenance. It shows how PACS are used in radiology, teleradiology, cardiology, pathology, and radiation oncology. The authors specifically cover PACS system components, quality control, IT infrastructures, networks, and data storage technologies. • Explains how PACS are used in radiology, teleradiology, cardiology, pathology, and radiation oncology • Describes industry standards, such as DICOM, HL7, and IHE, as well as security, privacy, and safety regulations, including HIPAA • Discusses the replacement of legacy systems • Provides case studies of PACS implementation in a clinical healthcare system and an academic institution
Selected Contents: PACS Servers and Workstations. Imaging Display Devices in PACS. Networking Technologies. Data Storage. Healthcare Information Integration. Teleradiology. Practical PACS Implementation. Upgrade and Replacing Legacy PACS. Enterprise PACS. Electronic Health Record and Personal Health Record Implementation. Quality Control, Security, and Downtime Management. Index. Catalog no. C8365, November 2010, 367 pp. ISBN: 978-1-4200-8365-1, $145.95 / £93.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Image Processing and Informatics Correction Techniques in Emission Tomography Edited by
Mohammad Dawood, Xiaoyi Jiang, and Klaus Schäfers European Institute for Molecular Imaging, Münster, Germany
“It is refreshing to have a text on emission molecular imaging relevant to animals and human beings with an emphasis on those factors that detract from resolution and quantification. This book implicitly distinguishes between molecular imaging of emitters and molecular imaging provided by magnetic resonance techniques … In sum, this book shows how researchers have overcome limitations in emission tomography noted 40 years ago and have brought the methods to the goal of high spatial resolution and quantification. Most importantly, these advances have enabled clinically useful applications not available to other diagnostic methods.”
Theoretical Foundations of Digital Imaging Using MATLAB® Leonid P. Yaroslavsky Tel Aviv University, Israel
Helping readers master digital imaging, this text presents a unified theoretical basis for understanding and designing methods of imaging and image processing. Designed for newcomers to imaging science and engineering, the book treats the theory of digital imaging as a specific branch of science, covering the subject in its entirety—from image formation to image perfecting. The author avoids using heavy mathematics and derives all formulas in full detail. To facilitate a deeper understanding of the major results, the book includes a number of exercises supported by MATLAB® programs, with the code available on the book’s CRC Press web page.
—From the Foreword by Thomas F. Budinger, University of California, Berkeley
• Emphasizes the connection between the original analog nature of images and image transformations and their computer implementation
• Provides a thorough treatment of state-of-the-art correction techniques
• Supports all mathematical formulations by their physical interpretation
• Covers different imaging modalities, including nuclear medicine imaging, hybrid systems, and optical imaging
• Avoids using heavy mathematics
• Addresses the special problems encountered in hybrid imaging
• Supports concepts and algorithms with interactive MATLAB exercises at the end of each chapter
• Explores the use of correction methods in biomedical imaging applications
Selected Contents: BACKGROUND: Biomedical Applications of Emission Tomography. PET Image Reconstruction. CORRECTIONS TECHNIQUES IN PET AND SPECT: Basics of PET and SPECT Imaging. Corrections for Physical Factors. Corrections for Scanner Related Factors. Image Processing Techniques in Emission Tomography. Motion Correction in Emission Tomography. Combined Correction and Reconstruction Methods. RECENT DEVELOPMENTS: Introduction into Hybrid Tomographic Imaging. MRBased Attenuation Correction for PET/MR. Optical Imaging. Index.
• Derives all formulas in full detail without skipping intermediate steps
• Provides downloadable MATLAB files for the exercises at www.crcpress.com
Selected Contents: Introduction. Mathematical Preliminaries. Image Digitization. Discrete Signal Transformations. Digital Image Formation and Computational Imaging. Image Resampling and Building Continuous Image Models. Image Parameter Estimation: Case Study— Localization of Objects in Images. Image Perfecting. Index. Catalog no. K12836, November 2012, c. 511 pp. ISBN: 978-1-4398-6140-0, $99.95 / £63.99 Also available as an eBook
Catalog no. K10659, April 2012, 287 pp. ISBN: 978-1-4398-1298-3, $119.95 / £76.99 Also available as an eBook
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Also of Interest An Introduction to Radiation Protection Sixth Edition Alan Martin, Sam Harbison, Karen Beach, and Peter Cole
Introduction to BioMEMS Albert Folch University of Washington, Seattle, USA
“Overall, the sixth edition maintains the high standards of its predecessors and should remain as a key reference text for those working in radiation protection.” —Journal of Radiation Protection
The sixth edition of this established text takes readers through the general background of the subject, the technical principles underlying the control of radiation hazards, radiation detection and measurement, and the biological effects of radiation. The book also addresses radiation protection issues in the nuclear industry, the non-nuclear sector, and the medical field. Further specialized topics include risk assessment, waste management and decommissioning, radiological incidents and emergencies, relevant legislation, and organizational issues. • Incorporates clear diagrams and photographs as well as summary sections and revision questions that are suitable for beginners and more advanced radiation practitioners • Reflects current EU strategies and other European and international requirements and legislation, including ICRP103 • Covers more risk and risk assessment, decommissioning, and recent advances in radiation protection in medicine • Includes an image library and sample lectures
Selected Contents: The Structure of Matter. Radioactivity and Radiation. Radiation Units. Biological Effects of Radiation. Natural and Man-Made Radiation. The System of Radiological Protection. Radiation Detection and Measurement. The External Radiation Hazard. The Internal Radiation Hazard. Practical Health Physics Techniques. Radiation Protection in the Nuclear Industry. Radioactive Waste and the Decommissioning of Radioactive Facilities. … Catalog no. K18600, March 2012, 256 pp. Soft Cover, ISBN: 978-1-4441-4607-3 $52.95 / £32.99
“The field has been waiting for a true textbook that provides a practical, historical, authoritative, and comprehensive introduction to bioMEMS. It has finally arrived, courtesy of Albert Folch, complete with PowerPoint lectures and thoughtful homework questions. I highly recommend it.” —David J. Beebe, University of Wisconsin–Madison
“A comprehensive, colorful textbook on the important field of bioMEMS. I will definitely recommend to my students!” —Albert van den Berg, University of Twente
“Dr. Folch’s book is a monumental achievement which brings an authoritative and comprehensive account to the rapidly growing, multidisciplinary field of bioMEMS. Many working scientists and engineers as well as students will find this book fascinating.” —Mehmet Toner, Harvard Medical School
“This book successfully integrates microfabrication and the physics of microfluidics with numerous biological applications. It provides a visual feast of images that lead to a comprehensive understanding of many complex concepts. Applications presented range from biomolecules to cells, tissues, and organisms, and are presented in clear, logical steps. It serves as an outstanding text for advanced undergraduates and graduate students, as well as an excellent review for researchers who are new to the field.” —Fawwaz Habbal, Harvard University
Selected Contents: How Do We Make Small Things? Micropatterning of Substrates and Cells. Microfluidics. Molecular Biology on a Chip. Cell-Based Chips for Biotechnology. BioMEMS for Cell Biology. Tissue Microengineering. Implantable Microdevices. Appendix. Index. Catalog no. K10966, August 2012, 528 pp. ISBN: 978-1-4398-1839-8, $89.95 / £57.99 Also available as an eBook
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Also of Interest Introduction to Experimental Biophysics
Basic Clinical Radiobiology Fourth Edition Edited by
Michael C. Joiner Albert van der Kogel
Biological Methods for Physical Scientists Jay Nadeau
Radboud University Medical Center, Nijmegen, Netherlands
McGill University, Montreal, Quebec, Canada
This book deals with the biological aspects of radiotherapy. It presents the main ideas and significant scientific developments that underlie the radiotherapeutic management of cancer. New chapters in this edition cover the mechanisms of cell death, biological response modifiers, and biological image-guided radiotherapy. This edition also revises sections on the molecular basis of the radiation response, tumor hypoxia, and the dose-rate effect.
“This book is essential reading for any physical scientist who is interested in performing biological research.”
Selected Contents: Introduction: The Significance of Radiobiology and Radiotherapy for Cancer Treatment. IrradiationInduced Damage and the DNA Damage Response. Cell Death after Irradiation: How, When and Why Cells Die. Quantitating Cell Kill and Cell Survival. Models of Radiation Response. Dose-Response Relationships in Radiotherapy. LET and RBE. Tumor Growth and Response to Radiation. Fractionation: The L-Q Approach. The L-Q Approach in Clinical Practice. Modified Fractionation. Time Factors in Normal Tissue Response to Radiation. The Dose-Rate Effect. Pathogenesis of Normal Tissue Side Effects. The Volume Effect in Radiotherapy. The Oxygen Effect and Fractionated Radiotherapy. The Tumor Microenvironment and Cellular Hypoxia Responses. Therapeutic Approaches to Tumor Hypoxia. Combined Radiotherapy and Chemotherapy. Retreatment Tolerance of Normal Tissues. Molecular Image-Guided Radiotherapy with PET. MolecularTargeted Agents for Enhancing Tumor Response. Biological Response Modifiers in the Clinic: Tumor. Biological Response Modifiers: Normal Tissue. Molecular Targeting and Patient Individualization. Protons and Other Ions in Radiotherapy. Second Cancers after Radiotherapy. Catalog no. K18393, March 2009 ISBN: 978-0-340-92966-7, $68.95 / £42.99 Also available as an eBook
—Contemporary Physics
“… an ambitious text aimed at educating new graduate students about the important and most common techniques used in a modern biological physics laboratory; it could also serve nicely as a reference manual for advanced graduate students of new or underused protocols. … an essential part of the biophysicist’s collection.” —Jennifer L. Ross, Physics Today, August 2012
“The book provides a comprehensive overview of diverse methods in biophysics. It will be a great resource for every working scientist in the physical sciences. It would also be a great supporting text to read as part of an introductory course in biophysical methods, particularly for graduate students and postdocs entering the field from other disciplines.” —Anthony J. Koleske, Yale University
This text is a practical companion for physical scientists seeking to move into wet laboratory experiments and biological research areas. The book’s three main sections address genes, proteins, and expression systems. This structure allows readers to follow the steps involved in the production of nucleic acids and proteins and the different levels of purification required for each type of analysis.
Selected Contents: Introduction and Background. Molecular Cloning of DNA and RNA. Expression of Genes in Bacteria, Yeast, and Cultured Mammalian Cells. Protein Expression Methods. Protein Crystallization. Introduction to Biological Light Microscopy. Quantitative Cell Culture Techniques. Semiconductor Nanoparticles (Quantum Dots). Gold Nanoparticles. Surface Functionalization Techniques. Electrophysiology. Spectroscopy Tools and Techniques. Appendix. Glossary. Index. Catalog no. K11452, September 2011, 672 pp. Soft Cover, ISBN: 978-1-4398-2953-0 $93.95 / £59.99 Also available as an eBook
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N E W !
Encyclopaedia of Medical Physics Two-Volume Set Edited by
Slavik Tabakov, Franco Milano, Sven-Erik Strand, Cornelius Lewis, and Perry Sprawls
Get the Most Up-to-Date Encyclopaedia on Medical Physics ➢ Contains roughly 3,500 crossreferenced entries relating to medical physics and associated technologies—split into two volumes ➢ Co-published by the European Medical Imaging Technology e-Encyclopaedia for Lifelong Learning (EMITEL) consortium ➢ Supported by the International Organization for Medical Physics (IOMP) ➢ Features contributions from over 100 specialists ➢ Describes new and existing methods and equipment in medical physics ➢ Includes references, further reading, images, graphs, formulas, and examples
Catalog no. K12085 December 2012, 908 pp. ISBN: 978-1-4398-4652-0 $595.00 / £379.00 Also available as an eBook
CRC Press
Taylor & Francis Group
Medical Physics
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