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Contents Biomaterials & Medical Devices ..................................3 Bioprocessing ............................................................11 Nanobiotechnology ..................................................15 Biotechnology............................................................26 Medicine & Biology ..................................................34 Page 9

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Drug Discovery & Delivery ........................................37 General Resources & Industry Applications................39

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Biomaterials & Medical Devices Forthcoming!

The Medical Device R&D Handbook Second Edition Edited by

Theodore R. Kucklick TRKD Medical Devices, Los Gatos, California, USA

Praise for the First Edition: “This is the first in its class of multidisciplinary books for medical device innovators, reaching across several disciplines to capture what innovators need.” —Michael Gertner, MD, Co-Director, Surgical Innovation Program at Stanford University

“This is a resource that will help medical device innovators develop better products, and more focused companies, more quickly.” —Randy Williams, Founder, The Keiretsu Forum

“Finally, a real manual that for the first time supports efficient medical device development.” —Peter H. Muller, President, Interform Product Development

Due to tremendous technological advances in medical technology, the field of medical device design has grown in importance. The first edition of this volume grew to become the most popular resource in this category. Specially designed for medical device designers, biomedical engineering students, physician entrepreneurs, and medical device entrepreneurs, The Medical Device R & D Handbook, Second Edition explains the basics on how to prototype and develop a medical device. Highlighting the latest FDA regulations, it discusses the fundamentals of plastics, adhesives, medical needles, and rapid prototyping and provides tips and tools to save time and money. This updated and expanded second edition presents practical advice and interviews from key opinion leaders and pioneers in the field. Extensive references at the end of each chapter enhance additional study. About the Editor: Ted Kucklick works in the research and development of innovative medical devices. He is the co-founder of Cannuflow, Inc., a company dedicated to developing medical devices for orthopedic surgery. He earned a bachelor’s degree in product design from the Cleveland Institute of Art and has studied marketing and management a Baldwin-Wallace College in Berea, Ohio. Ted has completed the Cardiovascular Engineering certificate course at Stanford University and the Global BioEntrepreneur certificate course at the University of California, Berkeley. He is the inventor on several issued and pending patents and is a member of the IEEE/EMBS, IDSA, AMI, and SMIT professional societies. Contents: Medical Plastics

Catheter Building

In Vitro and In Vivo Studies

Medical Metals

Rapid Prototyping

Patents and Intellectual Property

Medical Adhesives

Medical Molding

Using Industrial Design

Specialized Materials

Medical Illustration

Human Factors in Medical Devices

Catheter Forming Operations

Regulatory Affairs

Balloon Forming

Needles and Cannulae

Interviews with Leaders and Pioneers

Catalog no. K10598, September 2012, c. 550 pp., ISBN: 978-1-4398-1189-4, $139.95 / £89.00 Also available as an eBook

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Biomaterials & Medical Devices Forthcoming!

Regenerative Engineering Edited by

Cato T. Laurencin and Yusuf Khan University of Connecticut Health Center, Farmington, USA

Traditional approaches to tissue repair involve tissue engineering, in which cells and biodegradable scaffolds are combined to repair damaged or diseased tissue. This method has been in use for almost 20 years, but more recently, the field of regenerative medicine—which involves the regeneration of damaged tissue and organs through the use of stem cells and cytokines—has emerged and is gaining momentum. The influx of these innovative approaches to tissue regeneration and repair has necessitated a re-examination of the available teaching tools for undergraduate and graduate students. Both tissue engineering and regenerative medicine have been taught at the undergraduate and graduate level through a varied selection of approaches, using an ever-widening spectrum of textbooks. Given the similarity between the two fields, it is important to examine where each approach overlaps and where each differs. Regenerative engineering is at the core of this overlap and distinction. It is the intersection of regenerative medicine and tissue engineering—where regenerative medicine focuses on the biological aspects of tissue regeneration via stem cells, factors, and cytokines, and tissue engineering focuses on the integration of materials science and life science. The challenge to future researchers is to understand both the research and the application of ideas to real-world problems. Regenerative Engineering provides a framework and a strategy through which future researchers can be educated in this direction. With introductory chapters in materials science and life science, the book uses a combination of fundamental lecture-based teaching and problem-based learning approaches that help develop students into future researchers capable of completing the translation of their work from the lab to the operating room. Using a similar structure in each chapter to provide continuity throughout the text, the book is enhanced with examples, case studies on clinically relevant issues, and extensive references to facilitate learning and encourage further study. Contents: Introduction Basic Cell Biology Morphogenesis and Developmental Biology Basic Anatomy and Physiology Basic Materials Science Biomaterials Introduction to Regenerative Engineering Organ Regenerative Engineering Cardiovascular Regenerative Engineering Musculoskeletal Regenerative Engineering Neural Regenerative Engineering

Catalog no. K10724, September 2012, c. 400 pp., ISBN: 978-1-4398-1412-3, $99.95 / £63.99 Also available as an eTextbook


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Biomaterials & Medical Devices Forthcoming!

Reliable Design of Medical Devices Third Edition Richard C. Fries Isorel, Inc., Fitchburg, Wisconsin, USA

The medical device industry is constantly evolving and as a result, texts that explore the reliability of these devices must keep pace with changes. With an emphasis on safety and a thorough analysis of hazards and risks, Reliable Design of Medical Devices, Third Edition addresses changes in methodology and discusses the latest thinking on reliability. The book provides working engineers with assistance in preparing, designing, and testing a product. Discussions on hazard analysis and reliability tools such as FMEA and FTA offer direction in assuring that the new device is safe and effective. Every chapter in this third edition has been completely updated and three new chapters have been added. Contents: BASICS OF RELIABILITY. Reliability. The Concept of Failure. REGULATIONS AND STANDARDS. The FDA. Medical Device Directives. Quality System Regulation (QSR). Standards Directly Related to Reliability. SPECIFYING THE DEVICE. The Medical Device as an Entity. Defining the Device. Requirements Engineering. Safety and Risk Management. Liability. Intellectual Property. Human Factors. Six Sigma. HARDWARE DESIGN AND TEST. Hardware Design. Hardware Risk Analysis. Hardware V & V. Hardware Data Analysis. SOFTWARE DESIGN AND TEST. Software Design. Software Coding. Software Metrics. Software Risk Analysis. Software V & V. Software Data Analysis. MANUFACTURING. Hardware Manufacturing. Software Manufacturing. Configuration Management. MAINTENANCE. Analysis of Field Data.

Catalog no. K14218, September 2012, c. 416 pp. ISBN: 978-1-4398-9491-0, $179.95 / ÂŁ114.00 Also available as an eBook

Coming Soon!

A Laboratory Course in Tissue Engineering Melissa Kurtis Micou University of California, San Diego, USA

Dawn Kilkenny University of Toronto, Ontario, Canada

A Laboratory Course in Tissue Engineering is a hands-on lab manual for tissue engineering (TE) instruction. It contains classic TE experiments as well as modern TE techniques, emphasizing the importance of engineering analysis, mathematical modeling, and statistical design of experiments. The book includes over 20 stand-alone experiments that provide more than a semester's worth of activities, allowing instructors to customize their courses. The authors present experiments that use equipment commonly found in labs equipped for tissue culture, and they include pre-lab and discussion questions for each experiment. They describe multiple formats useful for the presentation of results, including technical posters, extended abstracts, and technical reports. Contents: Getting Started in the Lab. Lab Safety. Essential Lab Skills for Tissue Engineers. Isolation of Primary Chondrocytes from Bovine Articular Cartilage. Measuring and Modeling Growth of a Cell Population. Purification of a Cell Population Using Magnetic Cell Sorting. Decellularized Matrices for Tissue Engineering. Effect of Plating Density on Cell Adhesion to Varied Culture Matrices. Dynamic vs. Static Seeding of Cells onto Biomaterial Scaffolds. Cell Patterning Using Microcontact Printing. Measuring and Modeling the Motility of a Cell Population Using an Under-Agarose Assay. Characterizing Matrix Remodeling Through Collagen Gel Contraction. Effect of Substrate Stiffness on Cell Differentiation. Effect of Culture Configuration (2D vs. 3D) on Matrix Accumulation. Combining in silico and in vitro Techniques to Engineer Pluripotent Stem Cell Fate. The Fahraeus-Lindqvist Effect: Using Microchannels to Observe Small Vessel Hemodynamics. Examining Single Cell Mechanics Using a Microfluidic Micropipette Aspiration System. Contribution of Tissue Composition to Bone Material Properties. Technical Communication: Presenting Your Findings. Appendices.

Catalog no. K13694, August 2012, 256 pp. Soft Cover ISBN: 978-1-4398-7893-4, $59.95 / ÂŁ38.99 Also available as an eBook

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. Biomaterials

& Medical Devices


Coming Soon!

Bacterial Cellulose

Biomaterials and Stem Cells in Regenerative Medicine

A Sophisticated Multifunctional Material

Edited by

Miguel Gama

Murugan Ramalingam

University of Minho, Braga, Portugal

University of Strasbourg. France

The first book dedicated to the potential applications and unique properties of bacterial cellulose (BC), Bacterial Cellulose: A Sophisticated Multifunctional Material covers the basic science, technology, and economic impact of this bulk chemical as well as the companies and patents that are driving the field. It reviews the biosynthesis and properties of BC, including genetics and characterization; discusses the advancing technology as it relates to product development, bioreactors, and production; and analyzes the economic impact of BC on a diverse range of industry applications, including materials and biomaterials, biological and polymer sciences, and electromechanical engineering. The book discusses intellectual property implications associated with BC and provides an overview of the products currently on the market or in the development process.

Seeram Ramakrishna National University of Singapore

Serena Best University of Cambridge, UK


Biomaterials and Stem Cells in Regenerative Medicine bridges the gap in experimental approaches and understanding among the key areas of biomedical research. It examines the basic science involved in structure and properties, techniques and technological innovations in processing and characterizations, and applications of biomaterials and stem cells in tissue regeneration. Coverage ranges from fundamental principles to current technological advancements in the major field of regenerative medicine at the macro/micro/nano/molecular scales. The authors discuss breakthroughs in biomaterials, stem cells, tissue engineering, and drug delivery and provide current perspectives of these key elements in the context of regenerative medicine.



Biosynthesis and Properties Genetics and Strain Improvement Bioreactors and Large Scale Production Applications Biomedical Engineering Food Papermaking Composites/Nanocomposites Organic Light Emitting Diodes (OLEDs) Microelectromechanical Systems (MEMS) Economic Analysis and Perspectives

Catalog no. K13216, September 2012, c. 250 pp. ISBN: 978-1-4398-6991-8, $99.95 / £63.99 Also available as an eBook

• Presents a self-contained resource for understanding the current perspectives on biomaterials and stem cells in regenerative medicine • Examines growth factors, stem cells, scaffolds, and biomaterials for tendon regeneration • Discusses biomaterials and stem cells for myocardial repair • Explores the processing of metallic biomaterials for a better cell response • Covers spatially designed nanofibrous membranes for periodontal tissue regeneration • Introduces smart biomaterial scaffold for in situ tissue regeneration Catalog no. K13711, June 2012, c. 552 pp. ISBN: 978-1-4398-7925-2, $149.95 / £95.00 Also available as an eBook


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Biomaterials & Medical Devices Biological and Biomedical Coatings Handbook Two-Volume Set Edited by

Sam Zhang Nanyang Technological University, Singapore

Important in today’s nanotechnology, biological and biomedical coatings have been studied extensively and are receiving much attention from researchers. A timely reference for both experts and newcomers, Biological and Biomedical Coatings Handbook: TwoVolume Set explores the latest developments in films and coatings for biological and biomedical applications. The text covers a wide array of material types, including sol-gel, bio-ceramics, polymers, glass, nanomaterials, and chitosan. It also addresses various processes for developing and implementing these coatings, including CVD and PVD, drug delivery, released-control coatings, and spectroscopy. The two volumes can also be purchased individually. Features: • Presents cutting-edge developments from world leaders in films and coatings research • Offers a simplified introductory stepping stone for new entrants to the field and a solid review for veterans • Covers processing, properties, and performance • Discusses sol-gels, bio-ceramics, polymers, glasses, nanomaterials, and other materials • Explores CVD and PVD • Includes information on drug delivery and released-control coatings • Gives practitioners up-to-date figures, tables, plots, and images to aid their work Contents VOLUME 1: Processing and Characterization. Bonelike Mineral and Organically Modified Bonelike Mineral Coatings. Synthesis and Characterization of Hydroxyapatite Nanocoatings by Sol–Gel Method for Clinical Applications. Hydroxyapatite and Other Biomedical Coatings by Electrophoretic Deposition. Thermal Sprayed Bioceramic Coatings: Nanostructured Hydroxyapatite (HA) and HA-Based Composites. Nanostructured Titania Coatings for Biological Applications: Fabrication an Characterization. Hydrothermal Crystallization with Microstructural Self-Healing Effect on Mechanical and Failure Behaviors of Plasma-Sprayed Hydroxyapatite Coatings. Bioceramic Coating on Titanium by Physical and Chemical Vapor Deposition. Coating of Material Surfaces with Layer-by- Layer Assembled Polyelectrolyte Films. Bioactive Glass-Based Coatings and Modified Surfaces: Strategies for the Manufacture, Testing, and Clinical Applications for Regenerative Medicine.

VOLUME 2: Applications. Sol-Gel Derived Hydroxyapatite Coatings on Metallic Implants: Characterization, In Vitro and In Vivo Analysis. Amorphous Carbon Coatings for Biological Applications. Biomedical Applications of Carbon-Based Materials. Impedance Spectroscopy on Carbon-Based Materials for Biological Application. Control of Drug Release from Coatings: Theories and Methodologies. Release-Controlled Coatings. Orthopedic and Dental Implant Surfaces and Coatings. Piezoelectric Zinc Oxide and Aluminum Nitride Films for Microfluidic and Biosensing Applications. Medical Applications of Sputter-Deposited Shape Memory Alloy Thin Films. Bioactive Coatings for Implanted Devices. Catalog no. K11126, May 2011, 976 pp., ISBN: 978-1-4398-2125-1, $249.95 / £159.00 Also available as an eBook

Biological and Biomedical Coatings Handbook Processing and Characterization

Catalog no. K12269, May 2011, 456 pp., ISBN: 978-1-4398-4995-8, $139.95 / £89.00 Also available as an eBook

Biological and Biomedical Coatings Handbook Applications

Catalog no. K12270, May 2011, 520 pp., ISBN: 978-1-4398-4996-5, $139.95 / £89.00 Also available as an eBook

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. Biomaterials

& Medical Devices

Essential Resources from Human Factors Engineering Consultant Michael E. Wiklund

Designing Usability into Medical Products

Usability Testing of Medical Devices

Michael E. Wiklund

Michael E. Wiklund, Jonathan Kendler, and Allison Yale Strochlic

Wiklund Research & Design, Inc., Concord, Massachusetts, USA

Wiklund Research Design, Inc., Concord, Massachusetts, USA

Design Science, Philadelphia, Pennsylvania, USA

Informative, practical, and engaging, Usability Testing of Medical Devices provides concrete, hands-on instruction for the busy professional. Recognizing that the intended readers, including marketers, engineers, and regulatory affairs specialists, have limited time, the book has been carefully designed to be concise and visual, allowing readers to absorb much in one sitting or move from one section to another as needed. The book provides a general understanding of usability testing and reviews key concepts, highlighting the challenges of validating that protects against dangerous errors that could lead to patient injury and death. An appendix contains a wealth of ancillary resources, including recommended books and reports, U.S. Food and Drug Administration publications, websites, available webinars on courses, and other tools.

"This book should be on the shelf of anyone involved in the development of medical products. Today, devices are getting more and more complex while caregivers as a whole are much less experienced. User-centered interface design has to make up the difference and this book gives you a plan."

Stephen B. Wilcox

Contents: Introduction Risk Management and Usability Testing The Commercial Imperative Testing Costs Anatomy of a Usability Test Types of Tests Writing a Test Plan Choosing a Participant Sample and Recruiting Participants Test Environments Adding Realism Selecting Tasks Conducting the Test Interacting with Participants Documenting the Test Documenting the Test Reporting Results Validation Testing

Catalog no. K10595, December 2010, 412 pp. ISBN: 978-1-4398-1183-2, $72.95 / £45.99 Also available as an eBook

—Nicholas Barker, formerly Vice President of Design, Datascope Corp

Advocating a user-centered approach to medical technology design, Designing Usability into Medical Products covers the essential processes and specific techniques necessary to produce safe, effective, usable, and appealing medical systems and products. Written by experts on user-centered research, design, and evaluation, the book provides a range of alternative approaches. The authors explore how to make medical devices safe and effective by involving users in the design process. They discuss specific design and evaluation methods and tools, present case studies of user-friendly medical technologies and corporate human factors programs, and supply related resources for medical design professionals. Features: • Presents case-specific guidance on designing user interfaces that will help prevent human error • Provides access to authoritative viewpoints and advice on proven methods for developing user-centered medical products • Offers specific design recommendations, such as how to design intuitive control panels • Contains case studies of human factor programs that illustrate how to approach the task, what the pitfalls are, and how to learn from them • Includes illustrations that substantiate the design guidance provided in the text Catalog no. 2843, February 2005, 376 pp. ISBN: 978-0-8493-2843-5, $139.95 / £89.00 Also available as an eBook


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. Biomaterials

& Medical Devices New!

ISO 13485 A Complete Guide to Quality Management in the Medical Device Industry Itay Abuhav Hinterforst, Switzerland

The United States and European Union now require the ISO 13485 Standard certification for medical device manufacturers. Written by an experienced industry professional, ISO 13485: A Complete Guide to Quality Management in the Medical Device Industry provides comprehensive instruction on the ISO 13485 Standard certification for quality control in medical device manufacturing. It covers all the requirements of ISO 13485 and offers a step-by-step comparison between the ISO 13485 and ISO 9001, enabling a sound understanding of these new procedures. Topics include management responsibility, resource management, and measurement, analysis, and improvement. Features: • Presents from-the-trenches advice from a quality manager • Clarifies and interprets the ISO 13485 Standard requirements • Discusses the harmonization of regulatory requirements with the quality management system • Integrates risk management activities throughout the realization processes (with reference to the ISO 14791 standard) • Translates the requirements and objectives into feasible activities and tasks for reader comprehension • Provides examples of how one can implement the requirements drawn from various sectors and industries Catalog no. K12946, October 2011, 374 pp. ISBN: 978-1-4398-6611-5, $129.95 / £82.00 Also available as an eBook

Materials Science of DNA Edited by

Jung-II Jin Korea University, Seoul, South Korea

James Grote AFRL/RXPS, Wright Patterson Air Force Base, Ohio, USA

As interest continues to grow, DNA is expected to become focal to nanobiotechnology because of its structural and chemical characteristics. With chapters written by experts in their respective fields, this text chiefly focuses on DNA’s role in the rapidly growing fields of nanoscience, nanotechnology, and biotechnology. It is the first to address the materials science facet of DNA, rather than its chemical, biochemical, or biological aspects. It includes tables, graphs, equations, and an ancillary CD-ROM to provide understanding of DNA and the great potential of this biopolymer as an advanced material. Catalog no. K11352, December 2011, 338 pp. ISBN: 978-1-4398-2741-3, $119.95 / £76.99 Also available as an eBook

Biomimetics Nature Based Innovation Edited by

Yoseph Bar-Cohen JPL/Caltech, Pasadena, California, USA

A review of the current state of the art of biomimetics, this book documents key biological solutions that provide a model for innovations in engineering and science. It explores a wide range of topics, including artificial senses and organs; mimicry at the cell–materials interface; modeling of plant cell wall architecture; biomimetic composites; artificial muscles; and biomimetic optics. The book also discusses applications of biomimetics in manufacturing, products, medicine, and robotics; biologically inspired design as a tool for interdisciplinary education; and the biomimetic process in artistic creation. Catalog no. K11566, September 2011, 788 pp. ISBN: 978-1-4398-3476-3, $159.95 / £99.00 Also available as an eBook

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. Biomaterials

& Medical Devices Handbook of Active Materials for Medical Devices

Biomaterials A Nano Approach

Advances and Applications

Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo

Edited by

Andres Diaz Lantada

From a multi-disciplinary point of view, this book examines basic concepts, various processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials specific to biomedical applications. Spanning their historical development and reviewing recent advances, it describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. With illustrative examples and a variety of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human health care systems. Catalog no. 47817, June 2010, 372 pp. ISBN: 978-1-4200-4781-3, $99.95 / £69.99

Universidad Politecnica de Madrid, Spain

This book covers biodevices, mainly implantable or quirurgical, for the diagnosis or treatment of different pathologies, which benefit from the use of active materials as sensors or actuators. Based on the additional functionalities of active or "intelligent" materials—both as sensors and actuators— the research presented in this book helps further development of medical devices. The results will help with the industrial expansion of these kinds of materials as part of more complex systems. Catalog no. N10471, September 2011, 350 pp. ISBN: 978-981-4303-36-1, $249.95 / £159.00 Also available as an eBook


Handbook of Harnessing Biomaterials in Nanomedicine

Porous Media Applications in Biological Systems and Biotechnology Edited by

Preparation, Toxicity, and Applications

Kambiz Vafai University of California, Riverside, USA

Edited by

Dan Peer

Exploring innovative approaches for applying existing porous media technologies to biomedical applications, this volume presents world-class scientists and engineers who address significant problems and discuss exciting research in biological systems. They cover various transport processes, mechanical behavior, and material properties of biological tissues from a porous media point of view. The book also explores pertinent aspects of experimental work and numerical techniques and discusses the modeling of several phenomena, including flow changes in cerebral aneurysms, biomass growth, marine systems, and tissue homeostasis and repair.

Biomaterials play a significant role in nanomedicine. Applications include drug delivery by polymers, lipids, and carbohydrates for the delivery of small molecules, and antibodies and peptides as targeting agents for therapeutics and diagnosis. This book comprises theoretical and experimental analysis of various biomaterials used in nanomedicine. It explores research methods and preparation techniques and describes several promising applications. It also examines the toxicity of nanocarriers, including those related to immune response, and presents success stories of biomaterials that have reached clinics.

Catalog no. 65416, August 2010, 632 pp. ISBN: 978-1-4200-6541-1, $149.95 / £95.00

Catalog no. N10498, January 2012, 424 pp. ISBN: 978-981-4316-46-0, $149.95 / £95.00

Also available as an eBook

Also available as an eBook


Tel Aviv University, Israel

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Bioprocessing Basic Transport Phenomena in Biomedical Engineering Third Edition Ronald L. Fournier University of Toledo, USA

Encompassing a variety of engineering disciplines and life sciences, the very scope and breadth of biomedical engineering presents challenges to creating a concise, entry level text that effectively introduces basic concepts without getting overly specialized in subject matter or rarified in language. Basic Transport Phenomena in Biomedical Engineering, Third Edition meets and overcomes these challenges to provide readers with the foundational tools and the confidence they need to apply these techniques to problems of ever greater complexity. Bringing together fundamental engineering and life science principles, this highly accessible text provides a focused coverage of key momentum and mass transport concepts in biomedical engineering. It offers a basic review of units and dimensions, material balances, and problem solving tips, and then emphasizes those chemical and physical transport processes that have applications in the development of artificial and bioartificial organs, controlled drug delivery systems, and tissue engineering. The book also includes a discussion of thermodynamic concepts and covers topics such as body fluids, osmosis and membrane filtration, physical and flow properties of blood, solute and oxygen transport, and pharmacokinetic analysis. It concludes with the application of these principles to extracorporeal devices as well as tissue engineering and bioartificial organs. Written in a style friendly to all readers, this text provides a quantitative understanding of the underlying physical, chemical, and biological aspects of the topic. Features: • Provides an introductory level text for students in bioengineering, chemical engineering, mechanical engineering, and the life sciences • Presents a basic understanding and the theories of transport in biological systems and then builds on this knowledge base to show real-world applications in the development and design of artificial organs, drug delivery systems, and tissue engineering • Includes numerous examples with a discussion of the numerical methods used to solve the problems • Contains an extensive bibliography of the research literature that supports the material in the text • Supplies illustrations with problems at the end of each chapter that provide readers the opportunity to explore in greater detail the material covered in each chapter Solutions manual available upon qualifying course adoption

Contents: Introduction A Review of Thermodynamic Concepts Physical Properties of the Body Fluids and the Cell Membrane The Physical and Flow Properties of Blood Solute Transport in Biological Systems Oxygen Transport in Biological Systems Pharmacokinetic Analysis Extracorporeal Devices Tissue Engineering Bioartificial Organs References Index

Catalog no. K11304, August 2011, 483 pp., ISBN: 978-1-4398-2670-6, $89.95 / £44.99 Also available as an eBook

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Bioprocessing New!

Disposable Bioprocessing Systems Sarfaraz K. Niazi Pharmaceutical Scientist Inc., Deerfield, Illinois, USA

Because of many misconceptions, the biological drug manufacturing industry does not fully utilize disposable components, despite their wide availability. Regulatory and environmental concerns, however, will eventually compel manufacturers to adopt disposable systems. Making a strong case for disposables, this book demonstrates the true potential of these systems. Written by a researcher and professor with hands-on experience in designing, establishing, and validating biological manufacturing facilities worldwide, and creating model facilities using maximum disposable technology, this book is a comprehensive introduction to understanding disposable systems. It gives an overview of the current state of the disposable bioprocessing industry, resolves controversial issues, and guides readers in choosing disposable components that meet their needs. An important chapter on safety addresses facts and myths about the use of plastics and elastomers—including the issue of leaching— and explains how to ensure regulatory compliance. The book describes the equipment and systems available to prepare the starting materials for the manufacturing of biological drugs—from disposable containers to filters. The author also discusses costs, regulations, and concerns about waste disposal and shares his predictions for the future of the disposable bioprocessing industry. A practical manual for those interested in the transition to disposable systems, this book will also interest students of bioprocessing. It offers a timely view of disposable bioprocessing technology as a "game changer" that will facilitate developing new drugs and conducting research in the emerging field of stem cells and gene therapy. Contents: The Bioprocessing Industry—An Introduction Safety of Disposable Systems Containers Mixing Systems Disposable Bioreactors Connectors and Transfers Controls Downstream Processing Filling and Finishing Systems Filtration Regulatory Compliance Environmental Concerns Epilogue Bibliography Index

About the Author: Sarfaraz K. Niazi has been teaching pharmaceutical sciences and conducting research in the field of drug and dosage form development for over 35 years. A former professor at the University of Illinois, Dr. Niazi has written over a hundred papers, dozens of books, and owns numerous patents for his inventions in the field of drug development and biopharmaceutical processing, including patents on novel bioreactors. His first book on the subject, Handbook of Biogeneric Therapeutic Proteins (CRC Press), was widely received as a primer in the field of biological manufacturing. Dr. Niazi has hands-on experience in designing, establishing, and validating biological manufacturing facilities worldwide. Catalog no. K12983, December 2011, 322 pp., ISBN: 978-1-4398-6670-2, $149.95 / £95.00 Also available as an eBook


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Bioprocessing The Metabolic Pathway Engineering Handbook Edited by

Christina D. Smolke Stanford University, California, USA

Christina D. Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In The Metabolic Pathway Engineering Handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in this field. With a wealth of cutting edge research and analysis, this work also serves as an invaluable resource for those seeking to add their own contributions. Organized by topic, this reference is available as two volumes that can be purchased individually or as a set. The Metabolic Pathway Engineering Handbook: Fundamentals provides an overview of the field with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction models, the regulation of metabolic pathways, and genome scale and multiscale modeling tools. In addition, it covers the development of appropriate hosts for metabolic engineering, including the use of Escherichia coli, Bacillus subtilis, Streptomyces, yeast, filamentous fungi, and mammalian cells using cell culture. The Metabolic Pathway Engineering Handbook: Tool and Applications delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies, including recent research on genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. This volume also looks at emerging applications for producing fine chemicals, drugs, and alternative fuels. Fundamentals Contents: Introduction and Preface to Handbook; Christina D. Smolke Cellular Metabolism; Vincent Martin Balances and Reaction Models; Walter van Gulik Regulation of Metabolic Pathways; James Liao Modeling Tools for Metabolic Engineering; Costas Maranas Developing Appropriate Hosts for Metabolic Engineering; Jens Nielsen Tools and Applications Contents: Evolutionary Tools in Metabolic Engineering; Claudia Schmidt-Dannert Gene Expression Tools for Metabolic Pathway Engineering; Christina D. Smolke Applications of Emerging Technologies to Metabolic Engineering; Jay Keasling Future Prospects in Metabolic Engineering; Bernhard Palsson and Sang Yup Lee Appendix I: Tools for Experimentally Determining Flux through Pathways; Ralf Takors Appendix II: Applications; Brian Pfleger and Brian Brazeau The Metabolic Pathway Engineering Handbook: Fundamentals Catalog no. K10164, July 2009, 678 pp., ISBN: 978-1-4398-0296-0, $174.95 / £112.00 Also available as an eBook

The Metabolic Pathway Engineering Handbook: Tools and Applications Catalog no. 77651, July 2009, 581 pp., ISBN: 978-1-4200-7765-0, $174.95 / £112.00 Also available as an eBook

Save on the Set! Catalog no. 3923, August 2009, 1259 pp., ISBN: 978-0-8493-3923-3, $269.95 / £165.00 Also available as an eBook

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Bioprocessing Distillation Control, Optimization, and Tuning


PAT Applied in Biopharmaceutical Process Development and Manufacturing

Fundamentals and Strategies

An Enabling Tool for Quality-by-Design

Lanny Robbins Larco Technologies LLC, Midland, Michigan, USA

Edited by

Emphasis on improved quality and performance of distilled products and the demand for reduced operating costs place a heavy burden on both the personnel responsible for profitability and the manufacturing department charged with operating the processing equipment. There have been dramatic improvements in the computer software and hardware used to simulate and model the distillation process and potential response to experimentation, but mastering the art of distillation process and control still requires solid understanding of a large body of information. With a focus on achieving product purity at low cost, Distillation Control, Optimization, and Tuning: Fundamentals and Strategies highlights core concepts. These include process variables for continuous binary distillation columns and the four basic control strategies, the distillate and bottoms product quality performance objectives, and the tuning of process control loops. Without dwelling on complex mathematical descriptions, the book presents the fundamentals of process control of a distillation column as a separation and purification unit operation. It covers the concepts and functional criteria that are critical to successful implementation of process control, as well as measurement and improvement of product quality performance. It describes how process control loops for distillation columns can be tuned for stable operation, with a balance between minimum variability from setpoint changes and excellent response to load disturbances.

Cenk Undey, Duncan Low, Jose C. Menezes, and Mel Koch This book summarizes the state of the art in process analytical technologies applied to various aspects of biopharmaceutical process development and manufacturing. The text summarizes regulatory perspectives, FDA/EMEA guidelines, and new industry expectations. It explores emerging technology, especially in the area of real-time monitoring for end-point control, as well as new sensor, analytical, and measurement technologies. The authors also present successful industrial-scale deployment case studies and strategies from the biopharmaceutical industry and discuss future trends. Catalog no. K11448, December 2011, 327 pp. ISBN: 978-1-4398-2945-5, $159.95 / ÂŁ99.00 Also available as an eBook

Macroporous Polymers Production Properties and Biotechnological/ Biomedical Applications Edited by

Bo Mattiasson and Igor Galaev Lund University, Sweden

Ashok Kumar Indian Institute of Technology, Kampur, India

This volume emphasizes the need to strike a balance between the details of hypotheses and good engineering judgment. The author outlines learning objectives at the beginning of each chapter and includes chapter-end summaries, exercises, and references to help readers acquire essential knowledge and understanding. The result is a resource that will inform future decisions for the design, operation, and troubleshooting of distillation process control systems.

Macroporous polymers are rapidly becoming the material of choice for many tissue engineering, bioseparation, and bioprocessing applications. This book addresses the production, characterization, and application of these polymers. The text considers traditional methods of production, including phase separation polymerization, leaching, foaming, and double emulsion, as well as newly emerging methods such as cryogelation. The chapters also detail the various applications of macroporous gels for the separation of biomolecules and for the cultivation of mammalian cells in bioreactors and tissue engineering.

Catalog no. K12689, April 2011, 144 pp. ISBN: 978-1-4398-5748-9, $149.95 / ÂŁ95.00

Catalog no. 84615, December 2009, 525 pp. ISBN: 978-1-4200-8461-0, $139.95 / ÂŁ89.00

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Nanobiomaterials Handbook Edited by

Balaji Sitharaman State University of New York at Stony Brook, USA

Nanobiomaterials exhibit distinctive characteristics, including mechanical, electrical, and optical properties, which make them suitable for a variety of biological applications. Because of their versatility, they are poised to play a central role in nanobiotechnology and make significant contributions to biomedical research and healthcare. Nanobiomaterials Handbook offers a broad introduction for those new to the subject and serves as a useful reference for advanced professionals. Analyzing major topics and disciplines in this arena, this volume: • Defines scope, current status, and future prospects of nanobiomaterials • Surveys nanobiomaterials and examines various synthesis and processing techniques important for developing nanobiomaterials • Explores the unique nanoscopic physicochemical properties of nanobiomaterials • Discusses potential applications, emphasizing unique challenges in the design, fabrication, and evaluation of biomaterials for a particular application or field • Provides a detailed overview of the interactions between bionanomaterials/biological systems and the biocompatibility issues associated with bionanomaterials Advances in nanobiomaterials requires a multidisciplinary approach spanning major fields in physical and biological sciences, engineering, and medicine with considerable collaboration between ethicists, regulatory bodies, and industry. This volume brings together the work of a team of world-renowned experts from various fields who discuss the vast potential for nanobiomaterials in a myriad of applications. Selected Contents: Nanobiomaterials: Current and Future Prospects. Multifunctional Gold Nanoparticles for Cancer Therapy. Synthesis, Processing, and Characterization of Ceramic Nanobiomaterials for Biomedical Applications. Synthesis, Properties, Characterization, and Processing of Polymeric Nanobiomaterials for Biomedical Applications. CarbonBased Nanomedicine. Synthetic and Toxicological Characteristics of Silica Nanomaterials for Imaging and Drug Delivery Applications. Peptide-Based Self-Assembled Nanofibers for Biomedical Applications. Electrostatically SelfAssembled Nanomaterials. Peptide-Based Nanomaterials for siRNA Delivery: Design, Evaluation, and Challenges. Nucleic Acid Nanobiomaterials. Emerging Technologies in Nanomedicine. Nanomaterials for Therapeutic Drug Delivery. Nanobiomaterials for Nonviral Gene Delivery. Nanobiomaterials for Cancer-Targeting Therapy. Nanobiomaterials for Ocular Applications. Nucleic Acid Based Nanobiosensing. Nanobiomaterials for Molecular Imaging. Gadolinium-Based Bionanomaterials for Magnetic Resonance Imaging. Nanostructured Materials for Improved Magnetic Resonance Imaging. Nanobiomaterials for Dual-Mode Molecular Imaging: Advances in Probes for MR/Optical Imaging Applications.

Catalog no. 94661, June 2011, 737 pp., ISBN: 978-1-4200-9466-4, $169.95 / £108.00 Also available as an eBook

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Nanobiotechnology New!

Handbook of Nanoscience, Engineering, and Technology Third Edition Edited by

William A. Goddard III, Donald Brenner, Sergey E. Lyshevski, and Gerald J. Iafrate The first and second editions of the Handbook of Nanoscience, Engineering, and Technology, published in 2003 and 2008, exemplified the progress in nanoscience toward the vision put forward by Richard Feynman in his 1959 address, “There is Plenty of Room at the Bottom.” Feynman speculated about manipulating materials atom by atom, challenging the technical community “to find ways of manipulating and controlling things on a small scale.” Inspired by his vision, nanoscience is today defined as the manipulation and control of materials at the spatial scale of a few hundred angstroms (one-thousandth of the width of a human hair) or less. The extraordinary progress in nanoscience over the last decade now allows for the tailoring and combining of the physical, biological, and engineering properties of matter at the atomistic level of nature’s architectural building blocks. Critical to progress in nanoscience has been the stunning advances in synthesis, fabrication, and processing to achieve designed nanostructures complemented by nanoscale resolution tool development that allows characterization at the nanoscale. Simultaneous with these experimental advances, theory and simulation based on first principles has advanced from hundreds of atoms to the millions of atoms involved in a nanodevice of 20 nm dimensions. These developments now enable atomistic level tailoring and control of materials, setting the stage for the next revolution of nanoscale manufacturing where scalable technologies are used to manufacture large numbers of devices—each with complex functionalities. The visionary challenge put forth by Feynman in 1959 is well on its way to becoming a reality. As a testimonial to this reality, the first two editions of the Handbook included broad categories of innovative nanoscience, engineering, and technology emerging in the 2003 and 2008 timeframe. The Third Edition extends the portfolio further, including additional chapters on nanoenergy, electronic optics in graphene, metamaterials, nanomaterials for energy storage devices, photovoltaics, DNA devices and assembly, digital microfluidic lab-on-a-chip, and more. This edition also updates select chapters that appeared in the second edition. Selected Contents: There’s Plenty of Room at the Bottom: An Invitation to Enter a New Fields of Physics Room at the Bottom, Plenty of Tyranny at the Top Twenty Years to Develop Nanotechnology: 2000-2020 Nanomagnet Logic Quantum Transport at the Nanoscale Spontaneous Emission of Bloch Oscillation Radiation in the Terahertz Regime Molecular and BioMolecular Processing: Solutions, Directions and Prospects Spin Field Effect Transistors: The Pros and the Cons Optical Behavior of Periodic Nanostructured Media: A Classical Electromagnetic (Mesoscopic) Approach Theory of Ballistic Electron Transport in n+–i–n+ Diodes: Properties in THz-Frequency Range. Nanoparticle Manipulation by Electrostatic Forces Biological- and Chemical-Mediated Self-Assembly of Artificial Micro- and Nanostructures Introduction to Nanomanufacturing Molecules on Semiconductors: Towards Molecular Logic

Catalog no. K12751, May 2012, c. 1093 pp., ISBN: 978-1-4398-6015-1, $149.95 / £95.00 Also available as an eBook


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Learning Bio-MicroNanotechnology

Nanotechnology and Human Health

Mel I. Mendelson

Ineke Malsch

Loyola Marymount University, Los Angeles, California, USA

Malsch Techno Valuation, Utrecht, Netherlands

A primary text for undergraduate nanotechnology courses, Learning Bio-Micro-Nanotechnology is designed for students who lack a cross-disciplinary background and knowledge of micro- and nanotechnology. Clearly and concisely written, it contains examples, questions, and problems divided into three hierarchical learning skills: understanding, analyzing, and evaluating the concepts. The author breaks down the boundaries between biology, chemistry, physics, engineering and ethics by co-mingling the vocabulary and concepts of these disciplines around bio-applications. Copiously illustrated, this text leans heavily towards biological and biomedical applications and includes a comprehensive chapter on ethics. A comprehensive solutions manual is available upon qualifying course adoption

Nanotechnology and Human Health reviews current scientific and technical developments in nanotechnology for biomedical, agrofood, and environmental applications. This collection of perspectives on the ethical, legal, and societal implications of bionanotechnology provides unique insight into contemporary technological developments. Readers with a technical background will benefit from the overview of the state-of-the-art research in their field, while those with a social science background will benefit from the discussion of realistic prospects of nanotechnology. The text includes a glossary and extensive end-of-chapter references.

Contents: Thinking Small and Big Bio-Molecules and Cells Molecular Chemistry Engineering Bits and Bytes Seeing Small Things Μ-Electro-Mechanical Devices Bio-Applications Risks-Nano or Mega Ethics and Social Values Predictions –Year 2025

About the Author: Mel I. Mendelson attained his Ph.D. in Materials Science from Northwestern University, one of the leading universities in bio-nanotechnology. He worked for 20 years in the micro-electronics and aerospace industries prior to entering academia in 1994. Currently, he is a professor of Mechanical Engineering at Loyola Marymount University.

Features: • Provides an overview of nanotechnology for biomedical, agrofood, and environmental applications • Reviews global trends in government industrial research • Offers a realistic and balanced analysis of the short- to medium-term implications for people and the environment • Details ways in which to lay the foundations for a global ethical code of conduct for nanotechnology Contents: Biomedical Nanotechnology Overview Nanotechnology and Agrofood and Water Bionanotechnology and the Environment Ethical, Legal, and Social Implication of Bionanotechnology

Catalog no. 8144, October 2012, c. 300 pp. ISBN: 978-0-8493-8144-7, $119.95 / £76.99 Also available as an eBook

Catalog no. 82035, October 2012, c. 600 pp. ISBN: 978-1-4200-8203-6, $89.95 / £57.99 Also available as an eBook

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Nanobiotechnology Nanotechnology


Understanding Small Systems, Second Edition

Nanofabrication Handbook

Ben Rogers

Edited by

Reno, Nevada, USA

Stefano Cabrini

Sumita Pennathur

Lawrence Berkeley National Lab., Berkeley, California, USA

University of California, Santa Barbara, USA

Satoshi Kawata

Jesse Adams

Osaka University, Japan

Nevada Nano, Inc., Reno, USA

“An impressive work covering all the important nanofabrication topics and contents … Highly recommended.”

Winner of a CHOICE Outstanding Academic Book Award 2011! " … this outstanding introduction to the broad field of nanotechnology provides a solid foundation for further study. Summing Up: Highly recommended.” —N. M Fahrenkopf, University at Albany, in CHOICE, 2011

Nano novices come from a wide variety of backgrounds, so an effective text must assume limited understanding of background material, not be overly focused on any particular area, and still maintain scientific rigor and quality. Fitting neatly between popular science books and high-level treatises, Nanotechnology: Understanding Small Systems, Second Edition works from the ground up to provide: • A detailed yet accessible introduction to one of the world’s fastest growing fields, understandable to members of a variety of disciplines • A clear presentation of real-world examples and original illustrations, as well as hundreds of homework problems of varying types, including multiple choice, true-false, in-depth calculation, and essay (with complete solutions manual) • A systems-based approach that illustrates how underlying areas of nano are assembled to create systems with unique functions and characteristics

—Professor Din Ping Tsai, National Taiwan University

While many books are dedicated to individual aspects of nanofabrication, what is needed is a single source that defines and explains the total vision of the field. Filling this gap, Nanofabrication Handbook presents a unique collection of the new and most important established approaches to nanofabrication. Contributors from leading research facilities and academic institutions around the world define subfields, offer practical instructions and examples, and pave the way for future research. Helping readers to select the proper fabricating technique for their experiments, the book provides a broad vision of the most critical problems and explains how to solve them. It includes basic definitions and introduces the main underlying concepts of nanofabrication. The book also discusses the major advantages and disadvantages of each approach and offers a wide variety of examples of cutting-edge applications. Each chapter focuses on a particular method or aspect of study. For every method, the contributors describe the underlying theoretical basis, resolution, patterns and substrates used, and applications. They show how applications at the nanoscale require a different process and understanding than those at the microscale. For each experiment, they elucidate key solutions to problems relating to materials, methods, and surface considerations.

Comparing nanoscale and macroscale systems reveals the complex and fundamental differences between phenomena at different scales and uncovers the specific challenges and opportunities of nano. With its engaging and entertaining style, this book provides a gateway into an exciting and rapidly evolving area of science.

A complete resource for this rapidly emerging interdisciplinary field, this handbook provides practical information for planning the experiments of any project that employs nanofabrication techniques. It gives readers a foundation to enter the complex world of nanofabrication and inspires the scientific community at large to push the limits of nanometer resolution.

Catalog no. K12225, July 2011, 421 pp. ISBN: 978-1-4398-4920-0, $99.95 / £63.99

Catalog no. 90526, February 2012, 546 pp. ISBN: 978-1-4200-9052-9, $129.95 / £82.00

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Nanobiotechnology New!

Simulations in Nanobiotechnology Edited by

Kilho Eom Korea University, Seoul, South Korea

A thorough presentation of state-of-the-art simulations for studying the nanoscale behavior of materials, Simulations in Nanobiotechnology discusses computational simulations of biomolecules and nanomaterials. The book gives readers insight into not only the fundamentals of simulation-based characterizations in nanobiotechnology, but also in how to approach new and interesting problems in nanobiotechnology using basic theoretical and computational frameworks. Presenting the simulation-based nanoscale characterizations in biological science, Part 1: • Describes recent efforts in MD simulationbased characterization and CG modeling of DNA and protein transport dynamics in the nanopore and nanochannel • Presents recent advances in continuum mechanicsbased modeling of membrane proteins • Summarizes theoretical frameworks along with atomistic simulations in single-molecule mechanics • Provides the computational simulation-based mechanical characterization of protein materials Discussing advances in modeling techniques and their applications, Part 2: • Describes advances in nature-inspired material design, atomistic simulation-based characterization of nanoparticles’ optical properties, and nanoparticle-based applications in therapeutics • Provides an overview of the recent advances made in experiment and simulation-based characterizations of nanoscale adhesive properties • Suggests theoretical frameworks with experimental efforts in the development of nanoreson-ators for future nanoscale device designs • Delineates advances in theoretical and computational methods for understanding the mechanical behavior of a graphene monolayer Catalog no. K11581, October 2011, 562 pp. ISBN: 978-1-4398-3504-3, $139.95 / £89.00 Also available as an eBook

Biological and Medical Sensor Technologies Edited by

Krzysztof Iniewski CMOS Emerging Technologies, Inc., Vancouver, British Columbia, Canada

Biological and Medical Sensor Technologies presents contributions from top experts who explore the development and implementation of sensors for various applications used in medicine and biology. Edited by a pioneer in the area of advanced semiconductor materials, the book is divided into two sections. The first part covers sensors for biological applications. Topics include: • Advanced sensing and communication in the biological world • DNA-derivative architectures for long-wavelength bio-sensing • Label-free silicon photonics • Quartz crystal microbalance-based biosensors • Lab-on-chip technologies for cell-sensing applications • Enzyme biosensors • Future directions for breath sensors • Solid-state gas sensors for clinical diagnosis The second part of the book examines sensors for medical applications. This section addresses: • Bio-sensing and human behavior measurements • Sweat rate wearable sensors • Various aspects of medical imaging • The future of medical imaging • Spatial and spectral resolution aspects of semiconductor detectors in medical imaging • CMOS SSPM detectors • CdTe detectors and their applications to gamma-ray imaging • Positron emission tomography (PET) Composed of contributions from some of the world’s foremost experts in their respective fields, this book covers a wide range of subjects. It explores everything from sensors and communication systems found in nature to the latest advances in manmade sensors. The end result is a useful collection of stimulating insights into the exciting applications of sensor technologies in everyday life. Catalog no. K13895, February 2012, 412 pp. ISBN: 978-1-4398-8267-2, $149.95 / £95.00 Also available as an eBook

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Nanobiotechnology Applied Optics Fundamentals and Device Applications


Nanostructures and Nanoconstructions Based on DNA

Nano, MOEMS, and Biotechnology

Yuri M. Yevdokimov, V.I. Salyanov, and S.G. Skuridin

Mark A. Mentzer US Army Research Laboratory, Aberdeen Proving Ground, Maryland, USA

Engelhardt Institute of Molecular Biology, Moscow, Russian Federation

How does the field of optical engineering impact biotechnology? Applied Optics Fundamentals and Device Applications: Nano, MOEMS, and Biotechnology answers that question directly by integrating coverage of the many disciplines and applications involved in optical engineering, and then examining their applications in nanobiotechnology. Written by a senior U.S. Army research scientist and pioneer in the field of optical engineering, this book addresses the exponential growth in materials, applications, and cross-functional relevance of the many convergent disciplines making optical engineering possible, including nanotechnology, MEMS, (MOEMS), and biotechnology. Providing an unprecedented interdisciplinary perspective of optics technology, this book describes everything from core principles and fundamental relationships to emerging technologies and practical application of devices and systems—including fiber-optic sensors, integrated and electro-optics, and specialized military applications. The author places special emphasis on: • Fiber sensor systems • Electro-optics and acousto-optics • Optical computing and signal processing • Optical device performance • Thin film magnetic memory • MEMS, MOEMS, nano- and bionanotechnologies • Optical diagnostics and imaging • Integrated optics • Design constraints for materials, manufacturing, and application space Bridging the technology gaps between interrelated fields, this reference is a powerful tool for students, engineers and scientists in the electrical, chemical, mechanical, biological, aerospace, materials, and optics fields. Its value also extends to applied physicists and professionals interested in the relationships between emerging technologies and cross-disciplinary opportunities.

Written for chemists, physicists, molecular biologists, and students in related fields, Nanostructures and Nanoconstructions Based on DNA examines information presently available on the specific properties of metallic nanoparticles and compares their properties with those related to nano-objects formed by biological molecules. It also discloses details of formation and physicchemical peculiarities of the DNA nanostructures and DNA-based nanoconstructions. The reference contains a greater emphasis DNA physics and molecular biology than most other published titles in this area. The authors discuss how nucleic acid molecules and their complexes with chemical and biologically active compounds are of great interest in the development of various nanoscale systems and devices of practical importance. The book connects the liquid crystalline phase formation in DNA with possible nanotechnological applications. Contents: Nanoparticles and Biological Molecules Nanostructures with Synthetic Single-Stranded DNA Molecules Nanoconstructions Based on Spatially Ordered Double-Stranded DNA Molecules Practical Application of DNA-Based Nanoconstructions Stabilization of the DNA CLCD Particles and DNA NaC’s in Polymeric Hydrogel Catalog no. K14579, July 2012, c. 260 pp. ISBN: 978-1-4665-0569-8, $139.95 / £89.00 Also available as an eBook

Catalog no. K11430, May 2011, 368 pp. ISBN: 978-1-4398-2906-6, $129.95 / £82.00 Also available as an eBook


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Nanobiotechnology Life at the Nanoscale Atomic Force Microscopy of Live Cells


Bionanotechnology Maheshwar Sharon

Edited by

IIT Bombay (Retired), Birla College, Nanotechnology Research Center, India

Yves Dufrêne

Madhuri Sharon

Universite Catholique de Louvain, Louvain-la-Neuve, Belgium

Monad Nanotech Pvt. Limited, Mumbai, India

Beginning with fundamentals and expanding to applications, Life at the Nanoscale: Atomic Force Microscopy of Live Cells provides a comprehensive overview of the use of atomic force microscopy (AFM) and related scanning probe microscopies for cell surface analysis. The book covers all cell types from viruses and protoplasts to bacteria and animal cells. The contributors discuss a range of advanced AFM modalities, including high-resolution imaging, nanoindentation measurements, recognition imaging, and single-molecule and single-cell force spectroscopy.

Highlighting the human applications of the science, this volume discusses the fundamental concepts and underlying science of bionanotechnology and the bionanomachines that result from advances in this exciting new field. Distilling the author’s research and groundbreaking original experimentation, chapters cover bionanomachines and their use with and manipulation of DNA, RNA, proteins, carbohydrates, and lipids. Well-documented and authoritative, the book offers students and scientists alike the foundational information required to advance this powerful and potentially life-altering field.

Enhanced with numerous color illustrations, the book covers methodologies for preparing and analyzing cells and membranes of all kinds. The contributors highlight recent examples to illustrate the power of AFM techniques in life sciences and nanomedicine. About the Editor: Yves Dufrêne received his engineering degree in Chemistry and Bioindustries in 1991 and a PhD in Biophysical Chemistry in 1996 at the Université Catholique de Louvain (UCL) in Belgium. After completing postdoctorate work at the Naval Research Laboratory in Washington, D.C. in 2000, he became a research associate of the Belgian National Fund for Scientific Research and a lecturer in Physical Chemistry and Nanobiotechnology at UCL. He is currently the head of the Laboratory of Chemistry of Interfaces. Catalog no. N10435, August 2011, 460 pp. ISBN: 978-981-4267-96-0, $149.95 / £95.00 Also available as an eBook

Catalog no. K12393, April 2012, 300 pp. ISBN: 978-1-4398-5214-9, $79.95 / £49.99


Electrokinetic Particle Transport in Micro/Nanofluidics Direct Numerical Simulation Analysis Shizhi Qian and Ye Ai Old Dominion University, Norfolk, Virginia, USA

This book covers electrokinetic particle transport in micro/nano-fluidics involving electrophoresis, dielectrophoresis, electro-osmosis, and inducedcharge electro-osmosis. It emphasizes the direct numerical simulation of electrokinetic particle transport phenomena and provides several supportive experimental studies. The authors use COMSOL Multiphysics to conduct all the numerical simulations presented and include the corresponding script files in the appendix. The book is suitable as a resource for researchers in micro/nanofluidics and as a supplementary textbook for courses in electrokinetic transport phenomena in micro/nanofluidics. Catalog no. K12520, May 2012, c. 400 pp. ISBN: 978-1-4398-5438-9, $129.95 / £82.00 Also available as an eBook

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Nanobiotechnology Two Essential Volumes from Nanotechnology Pioneer and Entrepreneur Daviåd E. Reisner

Chirality in Biological Nanospaces


Reactions in Active Sites

Global Prospects

Nilashis Nandi

Edited by

University of Kalyani, India

Activity in the nanodimensional sites of large biological macromolecules greatly accelerates biological reactions. The chirality of the reactants also has a strong influence on the process, but its importance in such biological reactions has only recently begun to be understood. This book explores the influence of chirality on reaction mechanisms in such biological nanospaces. The text addresses ribosomal architecture and the influence of the chirality of amino acid and sugar in the active sites of transferase, oxidoreductases, hydrolases, lysases, isomerase, ligases, and other systems. Catalog no. K11852, July 2011, 209 pp. ISBN: 978-1-4398-4002-3, $119.95 / £76.99 Also available as an eBook

Colloids and Interfaces in Life Sciences and Bionanotechnology

As the impact and importance of nanotechnology continues to grow, nanomedicine and biotechnology have become areas of increased development. Drug delivery by nanoparticulates and nanocoatings for medicial devices are among the many new techniques on the horizon. To prepare for the future of medicine, biomedical engineers must have a deeply rooted understanding of the role of bionanotechnology. Catalog no. 7528, July 2008, 368 pp. ISBN: 978-0-8493-7528-6, $104.95 / £66.99 Also available as an eBook

Global Prospects Edited by

David E. Reisner The Nano Group, Inc., Farmington, Connecticut, USA

Willem Norde Wageningen University, The Netherlands, and University Medical Center Groningen, The Netherlands

This classroom-tested reference presents a concise introductory treatment of the physicochemical principles that determine interrelated colloidal and interfacial phenomena and their relevance to various life sciences. The book focuses on concepts that form the basis for understanding this behavior. Whether deciphering the spontaneous assembly of amphiphilic molecules or the intentional fouling of surfaces for the immobilization of cells in bioreactors, this book devotes special attention to reversible and soft colloids and discusses the colloidal domain in a historical perspective. Catalog no. K10890, June 2011, 495 pp. ISBN: 978-1-4398-1718-6, $129.95 / £39.99


The Nano Group, Inc., Farmington, Connecticut, USA

Bionanotechnology II

Second Edition

Also available as an eBook

David E. Reisner

The impact and importance of nanotechnology continues to grow, and nanomedicine and biotechnology have become areas of increased development. Biomedical engineers who work with biological processes and structures must have a deeply rooted understanding of the role of bionanotechnology, a rapidly evolving sector of the nanotechnology field. Bionanotechnology II: Global Prospects, a followup to the editor’s highly successful first volume, contains 26 entirely new contributions that provide a broad survey of research shaping this critical field. With coverage of technical and nontechnical areas, the book offers representative reporting on a wide variety of activity from around the world. It discusses the role of nanotechnology in novel medical devices, bioanalytical technologies, and nanobiomaterials. Catalog no. K10254, August 2011, 583 pp. ISBN: 978-1-4398-0463-6, $99.95 / £63.99 Also available as an eBook

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Nanobiotechnology Particulate Systems in Nano- and Biotechnologies

DNA LiquidCrystalline Dispersions and Nanoconstructions

Edited by

Yuri M. Yevdokimov, V.I. Salyanov, S.V. Semenov, and S.G. Skuridin

Wolfgang Sigmund, Hassan El-Shall, Dinesh O. Shah, and Brij M. Moudgil University of Florida, Gainesville, USA

Engelhardt Institute of Molecular Biology, Moscow, Russian Federation

Viewing recent advances in absorbed films and particle technology as a foundation for nano- and biotechnology innovations, this text offers comprehensive coverage of important topics in this area and summarizes the latest developments to occur worldwide over the past 10 years. International experts from European, Australian, and Asian nanobiocenters offer their critical perspectives on each specific field, examine the current status of technology, and discuss challenges for future research.

With detailed coverage of DNA liquid crystals, this book explores the condensation of various forms of DNA. The text presents the practical applications of the peculiar properties of the liquidcrystalline state of nucleic acids and shows how double-stranded nucleic acids represent an important tool for nanotechnology. The authors address modeling DNA molecules under laboratory conditions and they clarify the role of these molecules in living cells and for directed, artificial regulation of biological activity.

Catalog no. 7436, December 2008, 385 pp. ISBN: 978-0-8493-7436-4, $169.95 / £108.00

Catalog no. K13273, September 2011, 304 pp. ISBN: 978-1-4398-7146-1, $139.95 / £89.00

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Medical Nanotechnology and Nanomedicine

Also available as an eBook

Micro and Nano Techniques for the Handling of Biological Samples

Harry F. Tibbals

Jaime Castillo, Winnie Edith Svendsen, and Maria Dimaki

University of Texas Southwestern Medical Center, Dallas, USA

Technical University of Denmark, Lyngby

A highly accessible overview of alternative and conflicting concepts in the rapidly developing nanotechnology revolution, this reader-friendly guide reviews current research and development in nanoscience and illustrates the accomplishments and possibilities for application in nanomedicine. Divided into three parts, the first presents a historical background, the second investigates the current status of the field and its applications, and the third looks at future directions and possibilities. Representative examples, case summaries, and graphical illustrations enhance the text.

The techniques and tools used to understand many biological problems must be able to handle biological material without damaging or altering its natural state. This volume assesses various micro and nano techniques currently available to handle these materials. It shows how the techniques can effectively manipulate biological samples and highlights the advantages and shortcomings of each. The authors also help readers understand how the manipulation tools work and how to determine the appropriate tool for their needs.

Catalog no. K10431, September 2010, 527 pp. Soft Cover ISBN: 978-1-4398-0874-0, $72.95 / £45.99

Catalog no. K11354, August 2011, 255 pp. ISBN: 978-1-4398-2743-7, $129.95 / £82.00 Also available as an eBook

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Nanobiotechnology Digital Microfluidic Biochips


Fundamentals of Nanotechnology Gabor L. Hornyak, John J. Moore, Harry F. Tibbals, and Joydeep Dutta

Design Automation and Optimization Krishnendu Chakrabarty Duke University, Durham, North Carolina, USA

Winner of the 2009 CHOICE Outstanding Academic Textbook Award!

Tao Xu Cisco Systems, Cary, North Carolina, USA

Microfluidics-based biochips combine electronics with biochemistry for newly emerging application areas such as point-of-care medical diagnostics, onchip DNA analysis, automated drug discovery, and protein crystallization. This book envisions an automated design flow for microfluidic biochips. It offers newly designed automation solutions for problems unique to digital microfluidics. The authors provide a comprehensive methodology for the automated design, test, and use of robust and low-cost manufactured digital microfluidic systems. Catalog no. K11010, May 2010, 213 pp. ISBN: 978-1-4398-1915-9, $145.95 / £93.00 Also available as an eBook

“ . . . an outstanding, essential resource ... covers the entire spectrum of nanotechnology, including nanoelectronics, photonics, nanocomposites, and thin films ... can be read and appreciated by experts and non specialists alike. A revolutionary book in a revolutionary field.” —B. Ransom, formerly, University of California, San Diego, in Choice: Current Reviews for Academic Libraries

Catalog no. 48031, December 2008, 786 pp. ISBN: 978-1-4200-4803-2, $94.95 / £59.99 Also available as an eBook


Introduction to Nanoscience Gabor L. Hornyak, Joydeep Dutta, Harry F. Tibbals, and Anil K. Rao


Nanotechnology in Biology and Medicine

Metropolitan State College of Denver, Colorado, USA

"The figures are engaging and instructive, and the chapter reference lists are outstanding, ... exposes students to the complete scope of nanoscience, allowing them to bring their disciplinary knowledge to the table and to understand the science, language, and techniques used in allied fields … Summing Up: Highly recommended."

Methods, Devices, and Applications Edited by

Tuan Vo-Dinh Duke University, Durham, North Carolina, USA

The latest generation of nanodevices enables scientists to more accurately detect, analyze, and manipulate nanostructures at the molecular level. Emphasizing the application and design of nanomaterials, devices, and sensors, this book carefully details current methods, protocols, and instrumentation for biomedical applications such as stem cell research, gene diagnostics, targeted drug delivery, and tissue engineering. Pioneers in the field offer a cohesive source of vital data, tool kits, references, and experimental insight. Topics include self-assembly and biomanufacturing.

—B. Ransom, formerly, University of California, San Diego, in Choice: Current Reviews for Academic Libraries

Catalog no. 48058, May 2008, 856 pp. ISBN: 978-1-4200-4805-6, $94.95 / £59.99 Also available as an eBook

A wealth of ancillary materials is available online for both titles Save when you buy the combined volume!

Introduction to Nanoscience and Nanotechnology

Catalog no. 2949, January 2007, 792 pp. ISBN: 978-0-8493-2949-4, $179.95 / £115.00

Catalog no. 47795, December 2008, 1640 pp. ISBN: 978-1-4200-4779-0, $149.95 / £96.00

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Nanobiotechnology New!

Understanding Nanomedicine An Introductory Textbook Rob Burgess Medical Nanotechnologies Incorporated, Richardson, Texas, USA

This book comprehensively covers a broad range of therapeutic and diagnostic applications of nanotechnology, providing descriptions of cuttingedge discoveries along with historical perspectives. The text focuses on nanomaterials and nanoparticles, the sectors that hold the most promise for the future of medicine. The author looks at how nanotechnology can impact cancer treatment, clinical neuroscience, tissue engineering, drug delivery, and diagnostics. He also discusses the worldwide governmental regulatory impact on nanomedicine. Catalog no. N10477, April 2012, 350 pp. ISBN: 978-981-4316-38-5, $149.95 / £95.00

Nanoimaging Edited by

Beth A. Goins and William T. Phillips University of Texas, San Antonio, USA

The first resource of its kind, this book examines cutting-edge research on the use of nanoparticles for in vivo diagnostic medical imaging and therapy. It discusses a variety of nanoparticles, including quantum dots, carbon nanotubes, dendrimers, gold nanoshells, metal nanorods, micelles, liposomes, polymers, MRI iron oxide particles, and microbubbles. Examples in the book include multifunctional nanoparticles designed for multimodality imaging and simultaneous diagnostic and therapy (theranostic) applications. Catalog no. N10430, September 2011, 350 pp. ISBN: 978-981-4267-09-0, $149.95 / £95.00 Also available as an eBook


CarbohydrateModifying Biocatalysts

Artificial Human Sensors Science and Applications

Edited by

Edited by

Peter Grunwald

Peter Wide

University of Hamburg, Germany

Orebro University, Sweden

Carbohydrates have long been minimized by the scientific community due to their complex structure and a lack of suitable experimental methods for structure determination. This book provides an overview of the structure, function, and application of carbohydrate-modifying biocatalysts. It explores glycoconjugates and carbohydrate-modifying enzymes and the key roles they play in biological processes such as recognition, signal transduction, and immune responses. It discusses research activities in glycoscience, including the development of several new pharmaceuticals to treat malaria, cancer, and other diseases.

As the aging population increases, the need grows for support mechanisms for elderly patients with limited sensing abilities. This volume discusses human and artificial sensing in conjunction with the human perception capabilities (auditory, taste, smell, vision, and touch). It provides an overview of the intriguing field of machine sensing and perception, discussing new intelligent technologies that enhance the natural sensing, perception, and mobility abilities of humans. It concludes with future possibilities in this nascent field.

Catalog no. N10454, October 2011, 846 pp. ISBN: 978-981-4241-67-0, $299.95 / £191.00

Also available as an eBook

Catalog no. N10431, March 2012, 220 pp. ISBN: 978-981-4241-58-8, $149.95 / £95.00

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Biotechnology New!

New Technologies and Applications

Methods for Studying Nucleic Acid/Drug Interactions

Edited by

Edited by

Narayan S. Hosmane

Meni Wanunu

Northern Illinois University, Dekalb, USA

Northeastern University, Boston, Massachusetts, USA

Boron has made a significant impact in our lives through its quiet use in fertilizers, fungicides, soaps, detergents, and heat-resistant glassware. Boron Science: New Technologies and Applications addresses the applications of boron in chemistry, industry, medicine, and pharmacology by explaining its role in problems such as catalysis and hydroboration as well as its use in superconductors, materials, magnetic/nonmagnetic nanoparticles, and medical applications, including cancer therapy.

Yitzhak Tor

Boron Science

Illustrating the practical versatility of boron, the 29 chapters are divided into seven major sections: • Boron for Living: Medicine • Boron for Living: Health and Nutrition • Boron for Living: Radioisotope • Boron for Living: Boron Neutron Capture Therapy • Boron for Electronics: Optoelectronics • Boron for Energy: Energy Storage, Space, and Other Applications • Boron for Chemistry and Catalysis: Catalysis and Organic Transformations More than just an updated compilation of progress in the applied science of boron, this book is a tribute to the legions of workers who have spent years conducting groundbreaking studies. The book celebrates these scientists and their protégés, who together transformed boron science into the exciting and growing area it is today. Catalog no. K11300, October 2011, 878 pp. ISBN: 978-1-4398-2662-1, $299.95 / £191.00 Also available as an eBook

University of California at San Diego, La Jolla, USA

"By focusing on a selection of novel and emerging techniques, Wanunu and Tor provide a remarkable overview of biophysical and computational advances in structure-based investigations of the interactions between nucleic acids and smallmolecule ligands. An impressive collection of approaches is described: analytical biophysical techniques alongside novel exploitation of chemical and computational tools. Indeed, the smart combination of results obtained by classical methods with state of the art biophysical approaches reveals astonishing insights, thus paving new research avenues in this central area of research." —Professor Ada Yonath, Weizmann Institute of Science, 2009 Nobel Laureate in Chemistry

Methods for Studying Nucleic Acid/Drug Interactions describes emerging, non-conventional methods for probing the interactions of small molecules with nucleic acids as well as modern computational methods for assessment. Highlighting novel methods for nucleic acid/ligand interactions, this volume: • Surveys possible future techniques and highlights their drawbacks and advantages with respect to commonly used tools • Introduces several classical techniques, including crystallography, NMR and mass spectroscopy, optical, and calorimetry-based techniques • Details diverse aspects of powerful fluorescence-based techniques, electrospray mass spectrometry (ESI-MS) techniques, electrophoresis-based techniques, surface plasmon resonance (SPR) detection, continuous wave (CW) EP, computational modeling, and microarray-based methods Case studies are included to clarify material and ample references encourage further study. Catalog no. K11829, December 2011, 392 pp. ISBN: 978-1-4398-3973-7, $119.95 / £76.99 Also available as an eBook


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Biotechnology Biotechnology Fundamentals Firdos Alam Khan Manipal University, Dubai, UAE

The focus of Biotechnology Fundamentals is to educate readers on both classical and modern aspects of biotechnology and to expose them to a range of topics, from basic information to complex technicalities. Other books cover subjects individually, but this text offers a rare topical combination of coverage, using numerous helpful illustrations to explore the information that students and researchers need to intelligently shape their careers. Keeping pace with the rapid advancement of the field, topics covered include how biotechnology products are produced, the differences between scientific research conducted in universities and that conducted in industry, which areas of biotechnology offer the best and most challenging career opportunities, and key laboratory techniques and protocols employed in the field. The contents of this book are derived from discussions between teachers and undergraduate students and designed to address the concepts and methods thought useful by both sides. Starting with the fundamentals of biotechnology, coverage includes definitions, historical perspectives, timelines, and major discoveries, in addition to products, research and development, career prospects, ethical issues, and future trends. Features: • Explores novel medical genetics topics such as intra-uterine insemination • Discusses the process of biotech product development, with suitable examples • Examines ethical issues within biotechnology research and product development (e.g., embryonic stem cells, cloning, gene therapy, and GM crops) • Presents information on current research trends • Includes learning objectives for each chapter, in addition to problems, lab assignments, references, and ancillary online resources • Suggests field trips that can be used to apply and better understand concepts and other material in the book Solutions manual available with qualifying course adoption

Selected Contents: Introduction to Biotechnology


Microbial Biotechnology

What Is Biotechnology?

Agricultural Biotechnology

Animal Biotechnology

Ethical and Regulatory Issues in Biotechnologyy

Agricultural Biotechnology

Genes and Genomics

Environmental Biotechnology

Medical Biotechnology


Medical Biotechnology

Industrial Biotechnology

Cell as the Building Block of Life


Environmental Biotechnology

Genes and Genetics

Other Emerging Fields of Biotechnology

DNA Replication

Product Development in Biotechnology

DNA Interactions with Proteins

Industrial Biotechnology

History of Biotechnology

DNA-Modifying Enzymes

Ethics in Biotechnology

Human Genome Project

DNA Methylation

Careers in Biotechnology

Major Scientific Discoveries in Biotechnology

DNA Mutation

Laboratory Tutorials

Proteins and Proteomics


Biotechnology as the Science of Integration

Recombinant DNA Technology

Animal Biotechnology

Catalog no. K11059, September 2011, 608 pp., ISBN: 978-1-4398-2009-4, $89.95 / £48.99 Also available as an eBook

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Biotechnology New!

Stem Cells and Revascularization Therapies Edited by

Hyunjoon Kong and Lawrence B. Schook University of Illinois Urbana-Champaign, USA

Andrew J. Putnam University of California - Irvine, USA

In the last few decades, significant advances in the biology and engineering of stem cells have enabled progress in their clinical application to revascularization therapies. Some strategies involve the mobilization of endogenous stem cell populations, and others employ cell transplantation. However, both techniques have benefited from multidisciplinary efforts to create biomaterials and other biomedical tools that can improve and control the fate of stem cells and advance our understanding of them. Stem Cells and Revascularization Therapies focuses on the fundamentals and applied studies in stem cell biology and provides perspectives associated with the development of revascularization strategies. To help readers understand the multidisciplinary issues associated with this topic, the book has been divided into four sections: • Section 1: Explores how to define, isolate, and characterize various stem and progenitor cell populations for neovascularization • Section 2: Summarizes some especially useful model systems and approaches used to regulate angiogenesis, vasculogenesis, and arteriogenesis, and explores their impact on the formation of functional vessels in vivo • Section 3: Focuses on stem cell homing to sites of injury and inflammation, as well as strategies to exploit this mobilization phenomenon • Section 4: Covers stem cell transplantation topics, including recreating features of endogenous stem cell niches to maintain the multipotency of transplanted cells and combinatorial delivery of cells and molecular factors Intended to inspire new contributions to improve the therapeutic efficacy, this volume outlines emergent findings and challenges regarding the use of stem cells in revascularization therapies. Overcoming the significant hurdles to our understanding of stem cell biology will enhance their utility in promoting new blood vessel formation. Contents: Part I Defining, Isolating, and Characterizing Various Stem and Progenitor Cell Populations for Neovascularization Embryonic Stem Cells

Regulation of Capillary Morphogenesis by the Adhesive and Mechanical Microenvironment

Part III Treating Cardiovascular Diseases by Enhancing Endogenous Stem Cell Mobilization

Building Blood Vessels Using Endothelial and Mesenchymal Progenitor Cells

Stem Cell Homing to Sites of Injury and Inflammation

Induced Pluripotent Stem Cells

In Vitro Vascular Tissue Engineering

Part II

Scaffold-Based Approaches to Maintain the Potential of Transplanted Stem Cells

Guiding Stem Cell Fate through Microfabricated Environments Spatial Localization of Growth Factors to Regulate Stem Cell Fate

Part IV

Combined Therapies of Cell Transplantation and Molecular Delivery


Catalog no. K10180, December 2011, 342 pp., ISBN: 978-1-4398-0323-3, $149.95 / £95.00 Also available as an eBook


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Biotechnology New!

OMICS Biomedical Perspectives and Applications Edited by

Debmalya Barh Institute of Integrative Omics and Applied Biotechnology, West Bengal, India

Kenneth Blum and Margaret A. Madigan LifeGen, Inc., San Diego, California, USA

“ … this book will be intensively useful to scientists from both academia and industry, teachers and professors, health professionals, and mostly students, who should be encouraged to study and learn from its wisdom.” —From the Foreword by Debasis Bagchi, PhD, MACN, CNS, MAIChE, Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy

A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting-edge omics research and novel technologies. They supply a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. The book collates recent developments in the field into a state-of-the-art framework for this discipline. Contents: SECTION I: Methodology and Application. Bioinformatics: A Brief Introduction to Changing Trends in Modern Biology. Nutrigenomics. Omics Approaches in Toxicology Research and Biomedical Applications. Stem Cells: Basics and Therapeutic Applications. Emerging Trends of Nanotechnology in Omics-Based Drug Discovery and Development. Magnetic Nanoparticles in Biomedical Applications. High-Throughput Screening in Medical Diagnosis and Prognosis. High-Throughput Omics: The Application of Automated High-Throughput Methods and Systems for Solutions in Systems Biology. Safety in Diagnostic Imaging Techniques Used in Omics.

SECTION II: Empirical Research. Molecular Genetics of Human Cancers: Modulation of the Tumor Suppressor Function of RB1 Gene Product in Human Vestibular Schwannomas. Forward Genetics Approach in Genomics: Functional Identification of Unknown Genes. Proteomics of Phagosomal Pathogens: Lessons from Listeria monocytogens and New Tools in Immunology.

SECTION III: Computational and Systems Biology. In a Quest to Uncover Governing Principles of Cellular Networks: A Systems Biology Perspective.

Intermolecular Interaction in Biological Systems. Implanted Brain-Machine Interfaces in Rats: A Modern Application of Neuromics.

SECTION IV: Therapeutics. Pharmacogenomics in Development of Disease-Specific Therapeutic Strategy. Omics Approaches in Cancer Biomarker and Targeted Anticancer Drug Discovery. Recent Advances in MicroRNA Expression Profiling Toward a Molecular Anatomy of Tumorigenesis and Applications for Diagnosis, Prognosis, and Therapeutics. Marine Metabolomics in Cancer Chemotherapy. Genome-Wide Association Studies of Type 2 Diabetes: Current Status, Open Challenges, and Future Perspectives. Cardiac Channelopathies: Applications of Genomics and Proteomics in Diagnosis and Therapy. Toward an Omic Perspective on Infectious Disease and Its Therapy: Integrating Immunoinformatics, Immunomics, and Vaccinomics. NeuroAIDS and Omics of HIV Vpr. Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome.

SECTION V: Future Perspective. Future Perspective: Paving a Path to Optimization of Health.

Catalog no. K12277, November 2011, 613 pp., ISBN: 978-1-4398-5008-4, $139.95 / £89.00 Also available as an eBook

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Biotechnology Coming Soon!

Biotechnology of Plasma Proteins

Gene Biotechnology

Roger L. Lundblad Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Third Edition William Wu, Helen H. Zhang, Michael J. Welsh, and Peter B. Kaufman Covering state-of-the-art technologies and a broad range of practical applications, the latest edition of Gene Biotechnology presents tools that researchers and students need to understand and apply today's biotechnology techniques. Many of the currently available books in molecular biology contain only protocol recipes, failing to explain the principles and concepts behind the methods outlined or to inform the reader of possible pitfalls in the methods described. Filling these gaps, this book: • Discusses a wide variety of approaches, from very basic methods to the latest, most sophisticated technologies • Contains clearly detailed, step-by-step protocols with helpful troubleshooting tips • Addresses the needs of researchers in academic and commercial environments • Guides graduate students in designing, implementing, and evaluating experimental projects. Each chapter covers the principles underlying methods and techniques, includes step-by-step descriptions of each protocol, and provides notes, tips, and a troubleshooting guide. The book includes sections on how to write a research paper for publication in English-language journals, how to protect research discoveries and inventions via patents, and practical methods of bio-calculation. Written by a team of internationally recognized scientists, this volume presents procedures as well as clear and simple explanations of the key principles and concepts behind the methods. It is a single, logically organized source for the most important new methodologies. This unique resource provides the tools to help ensure success in contemporary molecular and cellular biology research. Catalog no. K12153, May 2011, 575 pp. ISBN: 978-1-4398-4830-2, $149.95 / £95.00 Also available as an eBook

Discussing the role of plasma proteins in current biotechnology, Biotechnology of Plasma Proteins describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products and highlights products from albumin, intravenous immunoglobins, and coagulation. The book offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, and mass spectrometry. Contents: Source, Composition, and Function of Blood Plasma Fractionation and Plasma Protein Therapeutics Methods for the Analysis of Plasma and Plasma Protein Fractions Plasma/Serum Albumin.Plasma Immunoglobulins Factor VIII and von Willebrand Factor Plasma Proteinase Inhibitors (Serpins) Vitamin K dependent Proteins Miscellaneous Plasma Proteins.

About the Author: Roger L. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his PhD in biochemistry at the University of Washington. After postdoctoral work in the laboratories of Stanford Moore and William Stein at The Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill. He joined the Hyland Division of Baxter Healthcare in 1990. Currently, Dr. Lundblad works as an independent consultant at Chapel Hill, North Carolina, and writes on biotechnological issues. He is an adjunct professor of pathology at the University of North Carolina at Chapel Hill and the author or editor of several CRC Press publications. Catalog no. K12286, August 2012, c. 544 pp. ISBN: 978-1-4398-5026-8, $149.95 / £95.00 Also available as an eBook


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Biotechnology Sensors for Chemical and Biological Applications Edited by

Manoj Kumar Ram Palm Harbor, Florida, USA

Venkat R. Bhethanabotla University of South Florida, Tampa, USA

In recent years, sensor research has undergone a quiet revolution that will have a significant impact on a broad range of applications in areas such as health care, the environment, energy, food safety, national security, and manufacturing. Sensors for Chemical and Biological Applications provides a detailed discussion of the potential of chemical and biological sensors. It examines how they are meeting the challenges of chem-bio terrorism by monitoring through enhanced specificity, fast response times, and the ability to determine multiple hazardous substances. Exploring the nanotechnology approach and carrying this theme throughout the book, the chapters cover the sensing principles for chemical, electrical, chromatographic, magnetic, biological, fluidic, optical, and ultrasonic and mass sensing systems. They address issues associated with cost, synthesis, and testing of new low cost materials with high sensitivity, selectivity, robustness, and speed for defined sensor applications. The book extensively discusses the detailed analysis of future impact of chemical and biological sensors in day-to-day life. Successful development of improved chemical sensor and biosensor systems and manufacturing procedures will not only increase the breadth and depth of the sensor industry, but will spill over into the design and manufacture of other types of sensors and devices that use nanofabrication and microfabrication techniques. This reference not only supplies versatile, hands-on tools useful in a broad array of disciplines, but also lays the interdisciplinary groundwork required for the achievement of sentient processing. Catalog no. 3366, April 2010, 390 pp. ISBN: 978-0-8493-3366-8, $135.95 / £87.00 Also available as an eBook

Support Vector Machines and Their Application in Chemistry and Biotechnology Yizeng Liang, Qing-Song Xu, Hong-Dong Li, and Dong-Sheng Cao Central South University, Changsha, China

Support vector machines (SVMs) are used in a range of applications, including drug design, food quality control, metabolic fingerprint analysis, and microarray data-based cancer classification. While most mathematicians are well-versed in the distinctive features and empirical performance of SVMs, many chemists and biologists are not as familiar with what they are and how they work. Presenting a clear bridge between theory and application, Support Vector Machines and Their Application in Chemistry and Biotechnology provides a thorough description of the mechanism of SVMs from the point of view of chemists and biologists, enabling them to solve difficult problems with the help of these powerful tools. Topics discussed include: • Background and key elements of support vector machines and applications in chemistry and biotechnology • Elements and algorithms of support vector classification (SVC) and support vector regression (SVR) machines, along with discussion of simulated datasets • The kernel function for solving nonlinear problems by using a simple linear transformation method • Ensemble learning of support vector machines • Applications of support vector machines to near-infrared data Beneficial for chemical data analysis and the modeling of complex physic-chemical and biological systems, support vector machines show promise in a myriad of areas. This book enables nonmathematicians to understand the potential of SVMs and utilize them in a host of applications. Catalog no. K11127, May 2011, 211 pp. ISBN: 978-1-4398-2127-5, $119.95 / £76.99 Also available as an eBook

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Environmental Microbiology for Engineers

Colloids in Biotechnology

Volodymyr Ivanov

Monzer Fanun

Nanyang Technological University, Singapore

Al-Quds University, East Jerusalem, Palestine

Environmental Microbiology for Engineers examines how microbiology can be used in environmental research and practical applications. The book encompasses both fundamental and applied principles and explores topics such as the microbiology of water, wastewater, soil, and air biotreatment systems used in environmental engineering. It also covers civil engineering topics such as biocementation, biocorrosion, biofouling and biodeterioration of materials.

Colloids show great potential in a wide variety of applications, including drug delivery and medical imaging, and the design and fabrication of colloid systems has attracted considerable interest in the research community. Colloids in Biotechnology describes developments in the field of biotechnological applications in the past decade and bridges the gap between these research efforts and commercially viable options.

Edited by

This volume provides a thoroughly up-to-date introduction to current trends in environmental microbiology and engineering. Microbial classification is represented as a periodic table with theoretical connections between all prokaryotic groups, highlighting their environmental applications. Combining microbiological knowledge and environmental biotechnology principles in a readable fashion, the text includes topics such as: • Structures and functions of microbial cell and cell aggregates • Applied microbial genetics and molecular biology • Diversity and function of microorganisms in environmental engineering systems • Environmental bioengineering processes • Microbiological monitoring of environmental engineering systems • Microbiology of water and wastewater treatment • Biocementation and bioclogging of soil • Biocorrosion of constructions • Biodeterioration of materials • Biopollution of indoor environment Written in an accessible style, the book teaches with a minimal use of mathematical equations. A solutions manual is available with qualifying course adoption.

Striking a balance between theory and experiment, between principles and applications, and between molecular and physical approaches to the subject, the book assembles contributions from an international community of colloid scientists to provide a comprehensive reference on the role of colloids in biotechnology and biomedicine. The authors discuss new types of biosurfactants; mixtures of surfactants; and peptides, proteins, and polyelectrolytes. They also describe the formation and properties of magnetic colloids and review their applications in chemical biology and medicine. They highlight current progress in the design of self-assembled materials for biotechnology and cover the formation of nanofibres and the use of sol-gel technology in biology. The chapter authors have been given the freedom to present the spectrum of the relevant science, from pure to applied, in their particular topic. The compilation of this vast experience makes this text a valuable reference for those working in research and development in a range of technologies as well as academic scientists in the colloid and surface science field. Catalog no. K11511, September 2010, 547 pp. ISBN: 978-1-4398-3080-2, $169.95 / £108.00 Also available as an eBook

Catalog no. 92340, November 2010, 438 pp. ISBN: 978-1-4200-9234-9, $104.95 / £66.99 Also available as an eBook


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Biotechnology Systems Biology and Bioinformatics: A Computational Approach

Emerging Protein Biotherapeutics Edited by

Kayvan Najarian, Christopher N. Eichelberger, Siamak Najarian, and Shahriar Gharibzadeh

Iqbal S. Grewal

Emphasizing computational methods, this volume introduces systems biology and its impact on biology and medicine. The book reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. It includes techniques to discover genes, perform nucleotide and amino acid sequence matching, estimate static gene dynamic pathways, and predict the behavior of biological systems for important applications.

Given the speed at which antibody therapy is becoming readily accepted, a comprehensive industry guide is needed. This book maintains an overall emphasis on various therapeutic approaches and applications and provides critical discussions on the most significant areas of research in biologics. It focuses on the applications of protein biologics in autoimmunity and inflammation, hematological malignancies, and solid tumors. Each chapter presents the most informative and contemporary account of its subject available.

Catalog no. 46500, April 2009, 190 pp. ISBN: 978-1-4200-4650-2, $75.95 / £47.99

Catalog no. 63200, June 2009, 368 pp. ISBN: 978-1-4200-6320-2, $174.95 / £112.00

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Also available as an eBook

Preclinical Therapeutics, Seattle Genetics, Inc., Bothell, Washington, USA


Essentials of Biotechnology

Bioseparation Technology

R.C. Sobti and Suparna S. Pachouri

Neeraj Mishra and Akhilesh Dubey

University of the Punjab, India

Ane Books, India

A comprehensive treatise on biotechnology, this volume starts with a review of early applications that scientists employed long before the field was defined. It then examines the emergence of current methods, specialized tools, and cell culture- and nucleic acid-based technologies. It presents chapters on biotechnology in the areas of health, agriculture, environment, aquaculture, and food and explores the status of biotechnology in developing countries, with special reference to India. It also examines debated ethical considerations and discusses issues related to intellectual property rights and patents.

Designed for those with a background in engineering or biology, this text explores the fundamentals of the emerging field of bioseparation technology. The book begins with an introduction to bioprocesses and then presents focused chapters on cell disruption, filtration, centrifugation, adsorption, and extraction. The book also examines membrane separation processes, precipitation, chromatography, and electrokinetics. It describes methods of separation as well as finishing operations and formulation.

Catalog no. AB8284, November 2008, 750 pp. ISBN: 978-1-4200-8284-5, $135.95 / £87.00

Catalog no. N10039, December 2012, c. 300 pp. Soft Cover ISBN: 978-1-4398-0172-7, $49.95 / £31.99

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Biotechnology / Medicine & Biology Forthcoming!

The Law of Regenerative Medicine and Tissue Engineering

Illustrated Dictionary of Biotechnology Himanshu Arora

David S. Smith

Ane Books, India

Helping to support a common language in this rapidly evolving field, this dictionary includes a range of terms wide enough to satisfy the needs of any researcher, clinician, lawyer, investor, student, or instructor whose work involves contact with new advances in science and medicine. Written in an accessible style, it provides straightforward definitions and invaluable background information so that even complex terms require only a rudimentary understanding of the life sciences. Extensive crossreferencing expands individual definitions, enabling readers to follow a chosen theme. Illustrations are included where they enhance understanding. Catalog no. N10040, April 2009, 450 pp. Soft Cover ISBN: 978-1-4398-0173-4, $64.95 / £41.99

Coming Soon!

CMOS Nanoelectronics

Pepper Hamilton LLP, Pittsburgh, Pennsylvania, USA

Numerous clinical trials are currently in progress for complex tissue constructs and cell therapies. Providing an overview of those legal and regulatory elements that can significantly impact the clinical introduction of cell- and tissue-based products, The Law of Regenerative Medicine and Tissue Engineering is an important reference at both the federal and state level. Discussing guidelines for the numerous current clinical trials for complex tissue constructs and cell therapies, it also considers strategies for building patent portfolios for the increasing number of companies commercializing skin substitutes. It examines expanded cell populations for cartilage repair and extracellular materials intended to enable remodeling or repair at the implementation site. The book contains expert advice for navigating the FDA review process for market approval and includes extensive references at the end of each chapter to enhance further research and preparation. Contents:

Innovative Devices, Architectures, and Applications

Introduction: An Overview of the Emerging Legal Regime Governing Regenerative Medicine

Edited by

Ownership, Transfer and Use of Cell- and Tissue-Based Materials

Nadine Collaert

Intellectual Property

IMEC, Leuven, Belgium

This volume examines FinFET —one of the most important device architectures that have been widely researched to extend transistor scaling. Discussing FinFET’s advantages and integration challenges, it addresses topics such as high-density fin patterning, gate stack design, and source/drain engineering. The book explores circuit-related aspects, including the impact of variability on SRAM design, ESD design, and high-T operation. It also introduces a new device concept: the junctionless nanowire FET.

FDA Regulation of Tissue Engineered Medical Products (TEMPs) Reimbursement for Cell- and Tissue-Based Products and Therapies Liability Issues Postscript: Trends in Legislation, Regulation and Case Law for the Future of Regenerative Medicine Reference Materials: Relevant Federal and State Statutes and Regulations

Catalog no. N10509, June 2012, c. 300 pp. ISBN: 978-981-4364-02-7, $149.95 / £95.00

Catalog no. K11293, October 2012, c. 270 pp. Soft Cover ISBN: 978-1-4398-2650-8, $59.95 / £38.99

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Medicine & Biology

BioMEMS Science and Engineering Perspectives Simona Badilescu and Muthukumaran Packirisamy

Biomedical Microsystems Ellis Meng

Concordia University, Montreal, Quebec, Canada

University of Southern California, Los Angeles, USA

As technological advancements widen the scope of applications for biomicroelectromechanical systems (BioMEMS or biomicrosystems), the field continues to impact many aspects of life science operations and functionalities. Because BioMEMS research and development require the input of experts who use different technical languages and come from varying disciplines and backgrounds, scientists and students can avoid potential difficulties in communication and understanding only if they possess a skill set and understanding that enables them to work at the interface of engineering and biosciences.

Poised to dramatically impact human health, biomedical microsystems (bioMEMS) technologies incorporate various aspects from materials science, biology, chemistry, physics, medicine, and engineering. Reflecting the highly interdisciplinary nature of this area, Biomedical Microsystems covers the fundamentals of miniaturization, biomaterials, microfabrication, and nanotechnology, along with relevant applications.

Keeping this duality in mind throughout, BioMEMS: Science and Engineering Perspectives supports and expedites the multidisciplinary learning involved in the development of biomicrosystems. It starts with a balanced introduction of biological, engineering, application, and commercialization aspects of the field. With a focus on molecules of biological interest, the book explores the building blocks of cells and viruses. It also examines the molecules that form the self-assembled monolayers (SAMs), linkers, and hydrogels used for making different surfaces biocompatible through functionalization. Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-on-achip (LOC) and micro total analysis system (TAS), along with their pertinence to emerging point-ofcare (POC) and point-of-need (PON) applications. Features: • Provides a concise overview of BioMEMS principles • Incorporates modern applications • Covers fabrication techniques • Includes examples and problems in each chapter • Offers references, review questions, and case studies to aid comprehension Solutions manual available with qualifying course adoption

Catalog no. K10877, April 2011, 368 pp. ISBN: 978-1-4398-1699-8, $99.95 / £63.99 Also available as an eBook

Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, the book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. For readers with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application. It offers a starting point for understanding advanced topics and encourages readers to begin to formulate their own ideas about the design of novel bioMEMS. Features: • Emphasizes practical knowledge useful for application to real-world problems • Describes research and commercialized bioMEMS devices as well as emerging applications • Includes detailed examples, laboratory exercises, and a variety of problems • Contains numerous illustrations of concepts, processes, and devices • Offers downloadable original images for qualifying instructors at Solutions manual available with qualifying course adoption

Catalog no. 51229, September 2010, 408 pp. ISBN: 978-1-4200-5122-3, $94.95 / £59.99 Also available as an eBook

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Medicine & Biology The Delivery of Regenerative Medicines and Their Impact on Healthcare

Biology for Engineers

Edited by

Arthur T. Johnson

Catherine D. Prescott

University of Maryland, College Park, USA

Biolatris Ltd., Cambridge, UK

Dame Julia Polak Imperial College, London, UK

Based on input from an international panel of experts, this book provides first-hand experience of the challenges and opportunities facing the delivery of regenerative medicines to patients. It highlights key issues beyond science and clinical translation, such as finance and business models, intellectual property and regulatory landscapes, as well as questions of how regenerative medicines will be evaluated for reimbursement. It also covers legal issues relevant to regulators, insurers, investors, and pharmaceutical and biotech researchers. Catalog no. K11628, November 2010, 400 pp. ISBN: 978-1-4398-3606-4, $179.95 / £115.00

This entry-level text minimizes unnecessary memorization of connections and classifications and emphasizes concepts, technology, and the utilization of living things. Filled with practical examples, the book discusses biological responses from the perspectives of psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine. Offering numerous tables of useful information, it covers the scaling of biological responses and attributes as well as different types of applications related to biological systems. Catalog no. 77635, September 2010, 775 pp. ISBN: 978-1-4200-7763-6, $104.95 / £66.99 Also available as an eBook

Also available as an eBook

Mechanobiology Handbook Edited by

Introduction to Complexity and Complex Systems

Jiro Nagatomi

Robert B. Northrop

Clemson University, South Carolina, USA

University of Connecticut, Storrs, USA

At appropriate levels, mechanical stimuli are necessary for growth and maintenance of healthy tissues and organs. Mechanobiology examines the effects of mechanical force stimuli on cellular biological functions. The past two decades have seen a dramatic increase in the level of research in this area. Collecting the cutting-edge findings from a diverse range of scientists, this volume presents an overview of the basics in mechanics and cell biology. It is designed to stimulate new ways of thinking in current mechanobiology researchers.

Written for students and professionals in the fields of biomedical engineering, systems biology, biophysics, and physiology, this reference covers complexity issues within living systems. Topics include human responses to coping with complex systems, the Law of Unintended Consequences, the relation of complexity to evolution, and the complexity inherent in invertebrate immune systems and economic systems. A comprehensive glossary provides acronyms and terms relating to complex, nonlinear biological systems. Dynamic models and questions are included to further aid in understanding.

Catalog no. 91212, March 2011, 563 pp. ISBN: 978-1-4200-9121-2, $169.95 / £109.00 Also available as an eBook

Catalog no. K11775, December 2010, 551 pp. ISBN: 978-1-4398-3901-0, $83.95 / £53.99 Also available as an eBook


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Drug Discovery & Delivery Forthcoming!

Ocular Drug Delivery Systems Barriers and Application of Nanoparticulate Systems Deepak Thassu Managing Director, Actavis SSL R&D, Owings Mills, Maryland, USA

Gerald J. Chader University of Southern California Medical School, Doheny Eye Institute, Los Angeles, California,, USA

Written for academic and industrial researchers in the field of ophthalmology, this book presents research on the development of currently marketed devices and recent trends for the future delivery of drugs topically to the posterior eye. It includes chapters on ocular physiology and the application of nanoparticles-based delivery systems to enhance drug efficacy. Contributors include leading eye researchers, surgeons, and pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis.

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery Paul C. H. Li Simon Fraser University, Burnaby, British Columbia, Canada

Authored by one of the field’s pioneering researchers, this volume focuses on all key aspects of the microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and currently emerging advances. The book emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses.

Catalog no. K12138, October 2012, 416 pp. ISBN: 978-1-4398-4800-5, $169.95 / £108.00

Catalog no. K10977, February 2010, 418 pp. Soft Cover ISBN: 978-1-4398-1855-8, $99.95 / £38.99

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Also available as an eBook


Neurobiology of Huntington’s Disease

Applying Genomic and Proteomic Microarray Technology in Drug Discovery Second Edition Robert S. Matson Beckman Coulter, Fullerton, California, USA

Written for academics, researchers, and professionals within the field of pharmaceutical science and biology, this volume evaluates current scientific research using microarray technology in genomic and proteomic applications. The book highlights bead-based assays and the expanded role for microarrays in biomarker discovery and diagnostics. The section on omics-driven applications has been expanded to include chemical biology and metabolomics. A new chapter discusses multiplex assays and their future impact on biomarket discovery, drug discovery, companion diagnostics, and personalized medicine.

Applications to Drug Discovery Edited by

Donald C. Lo Duke University Medical Center, Durham, North Carolina, USA

Robert E. Hughes Buck Institute for Age Research, Novato, California, USA

Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, this volume focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics as well as the latest in high-throughput and highcontent screening. Exploring the interplay between academic and industrial research, the investment community, and non-profit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and clinical usage.

Catalog no. K12595, October 2012, 352 pp. ISBN: 978-1-4398-5563-8, $149.95 / £95.00

Catalog no. 9000, July 2010, 338 pp. ISBN: 978-0-8493-9000-5, $159.95 / £99.00

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Also available as an eBook

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Medicine & Biology 3D Cell-Based Biosensors in Drug Discovery Programs


Antisense Drug Technology Principles, Strategies, and Applications, Second Edition

Microtissue Engineering for High Throughput Screening

Edited by

William S. Kisaalita

Stanley T. Crooke

University of Georgia, Athens, USA

ISIS Pharmaceuticals Inc., Carlsbad, California, USA

Written by one of the foremost experts in this field, this book provides the latest information — from theory to practice — on challenges and opportunities for incorporating 3D cell-based biosensors or assays in drug discovery programs. It supplies a historical perspective and defines the problem 3D cultures can solve. It also discusses how genomics and combinatorial chemistry have changed the way drug are discovered and presents data from the literature to underscore the limitations in pharmaceutical industry performance under the new paradigm.

This second edition incorporates lessons learned from clinical trials and offers new directions and avenues of research and development. The book explains mechanisms of action, pharmacokinetics of delivery, and the therapeutic potential of antisense drugs, ologonucleotides, hybridizationbased drugs, duplex RNA, and more. Leading researchers consider the potential of antisense drugs for the alleviation of cardiovascular, metabolic, and inflammatory diseases as well as cancer and neurological and immune disorders.

Catalog no. 73494, June 2010, 404 pp. ISBN: 978-1-4200-7349-2, $135.95 / £87.00

Catalog no. 8796, July 2007, 848 pp. ISBN: 978-0-8493-8796-8, $269.95 / £165.00

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Also available as an eBook

Handbook of Analysis of Oligonucleotides and Related Products

Transdermal and Intradermal Delivery of Therapeutic Agents Application of Physical Technologies

Edited by

Ajay K Banga

Jose V. Bonilla

Mercer University, Atlanta, Georgia, USA

Girindus America, Cincinnati, Ohio, USA

G. Susan Srivatsa ElixinPharma, Encinitas, California, USA

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and degenerative disorders. This volume explores the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. The book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations. Catalog no. K11050, February 2011, 511 pp. ISBN: 978-1-4398-1993-7, $139.95 / £89.00

Interest in drug delivery systems is growing as the delivery of many drugs continues to be a problem due to safety, stability, and compliance issues. This is especially true for the increased number of biologic medicines. Transdermal delivery is an important part of such systems, and the use of physical enhancement methods to penetrate the skin barrier is growing in popularity. This book reviews the strategies available for the delivery of compounds into and through the skin. Catalog no. K10285, May 2011, 309 pp. ISBN: 978-1-4398-0509-1, $129.95 / £82.00 Also available as an eBook

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General Resources & Industry Applications New!


Quality Operations Procedures for Pharmaceutical, API and Biotechnology

Process Validation in Manufacturing of Biopharmaceuticals

Syed Imtiaz Haider and Erfan Syed Asif

Anurag Rathore

Third Edition Edited by Indian Institute of Technology, New Delhi

Julphar Gulf Pharm Industries, United Arab Emirates

Gail Sofer

Quality Operations Procedures for Pharmaceutical, API and Biotechnology classifies the various aspects of quality operations as separately designed operating procedures and provides a systematic description for each element. Addressing local and international compliance, the author presents technical solutions to fulfill the needs of quality assurance and quality control systems of all grades.

SofeWare Associates, Texas, USA

A practical resource, the text provides standard operating procedures for documentation guidelines, validation guidelines, handling of materials in microbiological labs, process simulation testing, conducting internal audits, and chemical and biological testing. An accompanying CD-ROM offers valuable key performance indicator templates. Selected Contents: Handling of Sampled Material. Control of Incoming Materials used in Production. Control of Bulk and Intermediate Products. Checking of Finished Products. Destruction of Disposal Samples after Complete Testing and Reference Samples after Expiry. Recording the Analysis and Controlling the Analytical Registers and Records. Testing of Finished Products. Microbiological Monitoring Program. Clothing in Microbiology Laboratory. Microbiological Media Handling. General Cleaning and Sanitation of Microbiological Laboratory. Managing Primary and Secondary Reference Standards in the Quality Control Laboratory. Handling of Raw/Packaging Materials and Finished Samples in Reference Room. Stability Testing Program. Control of Controlled Substances (Raw Material, Bulk and Finished Products). Rounding of Significant Numbers. Analytical Methods Transfer for New Products. Handling Out of Specification Results. Batch Auditing Procedure. Validation and Certification Guidelines. Product Complaints Handling Procedure. Sampling of Finished Products for Laboratory Testing. Sampling of Bulk Products for Laboratory Testing. Product Recall Procedure. Cream/Ointment In-process Audit Checks. Inspection of Physical Attributes/Characteristics of Coated/Uncoated Tablets. Powder In-Process Filling Audit Checks. Sealing Checks of Strips and Blisters. Tablets Compression Audit Checks. In-Process Checks for Finishing Lines. Internal QA Audit Guideline.

Process Validation in Manufacturing of Biopharmaceuticals, Third Edition explores strategies for selecting the most appropriate quality control processes. Offering practical guidelines, recommendations, and an abundance of industrial case studies, the book demonstrates various techniques and approaches in the validation of biopharmaceutical processes. The new edition addresses the numerous changes made in the pharmaceutical industry as well as the many modifications that have been made to regulations. The authors also cover advances in biotechnology. Features: • Presents process characterization techniques for scaling down unit operations used in biopharmaceutical manufacturing • Offers guidance and strategies for scaling down unit operations, including chromatography, chemical modification reactions, ultrafiltration, and microfiltration • Provides practical methods to test raw materials and in-process samples • Overviews the new validation paradigm of process development, process qualification, and continuous monitoring • Discusses background and industry commentary on the final version of the FDA 2011 Guidance for Industry on Process Validation Principles and Practices • Considers potential risks from adventitious agents, which include viruses, bacteria, fungi, mycoplasma, and transmissible spongiform encephalopathies The book stresses the importance of taking a riskbased approach towards computerized system compliance and describes how it adds value to the product and process that is commensurate with cost. It also presents strategies for a team approach to ensure process validation is carried out according to current expectations.

Catalog no. K14029, June 2012, c. 224 pp. ISBN: 978-1-4398-8690-8, $129.95 / £82.00

Catalog no. K12321, May 2012, c. 540 pp. ISBN: 978-1-4398-5093-0, $169.95 / £108.00

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Also available as an eBook

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Essential Resources from Esteemed Author Syed Imtiaz Haider

Biotechnology A Comprehensive Training Guide for the Biotechnology Industry Syed Imtiaz Haider, Ph.D. and Anika Ashtok Julphar Gulf Pharmaceutical Industries, United Arab Emirates

All manufacturing companies face the daunting task of designing an employee training matrix that meets the rigor of national and international regulatory standards. Answering the call for a one-stop resource that focuses exclusively on this multi-faceted, high-tech industry, Biotechnology: A Comprehensive Training Guide for the Biotechnology Industry provides ready-to-implement instructional templates that save time and expense without cutting corners on critical elements. This complete, single-source reference contains 28 complete biotechnology courses and a customizable CD-ROM with hands-on training tools. The book also provides time-saving information on how to orient employees involved in writing and executing batch manufacturing and in-process control documents. Key Benefits: • Contains adaptable training text, test summaries and papers, test answers, and certificates of completion • Streamlines the training process, maximizing efficiency • Boosts the marketing edge over competitors This valuable training tool presents step-by-step guidance for optimizing research and development expenditures. It provides tips on avoiding marketing delays, gaining a competitive advantage, and reducing product development failures. Organizations that utilize the material in this guide will developed skilled manpower while maintaining local and international regulatory compliance. Contents: Microbial Growth Text

Centrifugation Text

Industrial Biosafety Text

Culturing Microorganisms

Homogenization Text

Certificate of Attainment

Bioreactor Configurations Text

Refolding of Inclusion Bodies Text

Biotechnology Training Records

Bioreactor Design Features Text

Solubilization and Refolding of Proteins Text

Recommended Readings

Lyophilization: Growing with Biotechnology Text

Inclusion Bodies Solubilization Text

Shear Effects in Culture Text

Sludge Treatment Text

Energy Input in Bioreactors Text

Freeze Drying Text

Downstream Processing Text

Vacuum Drying Text

Mammalian Cell Cultures Text

Diafilteration Text

Plant Cell Cultures Text

Partition Chromatographs Text

Fermentation Text

Adsorption Chromatographs Text

Characteristics of Cells in Culture Text

Gel Filteration Chromatographs Text

Cell Lysis Text

Techniques of Genetic Engineering Text

Cells Fractionation Text

Appendix A ICH Harmonised Tripartite Guideline Appendix B Guidance for Industry by U.S Department of Health and Human Services – Food and Drug Administration – Center for Biologics Evaluation and Research (CBER) – February 1999 Appendix C EMEA European Medicine Agency Guideline Index

Catalog no. 84488, April 2009, 868 pp., Soft Cover, ISBN: 978-1-4200-8448-1, $107.95 / £69.99 Also available as an eBook


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Essential Resources from Esteemed Author Syed Imtiaz Haider Quality Control Training Manual

Cleaning Validation Manual

Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories

A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries

Syed Imtiaz Haider and Erfan Asif Syed Julphar Gulf Pharmaceutical Industries, United Arab Emirates

Written to help companies comply with GMP, GLP, and validation requirements imposed by the FDA and regulatory bodies worldwide, Quality Control Training Manual: Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality, safety, and efficacy. The book and its accompanying CD-ROM comprise detailed text, summaries, test papers, and answers to test papers, providing an administrative solution for management. Features: • Provides the FDA, Health Canada, WHO, and EMEA guidelines directly applicable to pharmaceutical laboratory-related issues • Offers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirements • Contains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industries • Includes a CD-ROM with downloadable training courses that can be adopted and directly customized to a particular organization • Supplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificate The biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles, with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the CD-ROM supply valuable tools for developing training matrices to achieve FDA, Health Canada, EMEA, MHRA UK, WHO, and GLP compliance.

Syed Imtiaz Haider, Ph.D. and Erfan Syed Asif, Ph.D. Julphar Gulf Pharmaceutical Industries, United Arab Emirates

With over 20 easy-to-use template protocols for cleaning validation of the most commonly used equipment, the Cleaning Validation Manual: A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries provides technical solutions to assist in fulfilling the training needs of finished pharmaceutical manufacturers. Drawing on the authors’ more than two decades of experience, the text offers hands-on training based on current approaches and techniques. The manual is organized as a database to support those involved in the development, manufacturing, auditing, and validation of bio-pharmaceuticals on a pilot scale, leading to scaled-up production. It also provides exclusive training guidelines in a CD-ROM to enable users to amend or adapt processes as necessary. Features: • Enables pharmaceutical companies to implement a cleaning validation program on-site without the help of external consultants • Provides a ready-to-use formula to develop a master plan, standard operating procedure, and validation protocols • Includes photographs of sampling points to enhance clarity • Covers a wide range of active ingredients with information on their level of solubility in water, potency, and toxicity • Allows validation professionals to create a worst-case matrix for different equipment • Contains a chapter on the regulatory guidelines from the FDA, HPFBI, WHO, and EMEA Catalog no. K11299, May 2010, 608 pp. ISBN: 978-1-4398-2660-7, $145.95 / £93.00 Also available as an eBook

Catalog no. K12268, February 2011, 484 pp. ISBN: 978-1-4398-4994-1, $139.95 / £89.00 Also available as an eBook

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General Resources & Industry Applications

Biotechnology Operations Principles and Practices Michael J. Roy University of Wisconsin-Madison, USA

Based on the author's extensive teaching experience, Biotechnology Operations: Principles and Practices introduces key biotechnology developments and covers critical elements of biotechnology operations. Comprehensive and practical, but with a focus on fundamentals, it emphasizes the themes of planning and integrating the seven key operational endeavors: scientific and management skills of biomanufacturing, clinical trials, nonclinical studies, project management, quality assurance, quality control, and regulatory affairs. The author discusses these subjects in relation to development planning, process and pathways, management of integrated projects, and the business and economic aspects of development. Describing the functional areas that must be successfully integrated to bring a biotechnology product to market, this book presents a roadmap and reference for biotechnology operations, integrating the functional areas through the processes of product planning and design and the practice of project management. It also applies lessons gleaned during past decades as novel products have been developed from emerging scientific discoveries. The lessons highlight development principles and practices that could reduce risk, resolve problems, and help the industry to bring safe and effective biotechnology products of the future to market more efficiently and quickly. Features: • Provides an introduction to each key biotechnology development subject in one volume • Incorporates an integrated approach, tying together the various functional areas • Emphasizes the need to both plan and integrate a program and provides the information with which to successfully lead such efforts • Uses relatively simple language, explains jargon, and uses diagrams to describe processes so subjects are easily understood Selected Contents: Introduction to Biotechnology Operations: Planning for Success. Biotechnology Operations. Marketing, Financial and Business. Considerations for Development. Product Development Planning. Summary of Planning for Success. Project Management. Project Management in Biotechnology. Background of Project Management. Project Management in Biotechnology. Project Management in Biotechnology. Operations. Project Management with Contracts and Collaborations. Tools for Effective Project Management. Summary of Project Management in Biotechnology Development. Regulatory Affairs. The U.S. Food and Drug Administration: Law and Regulations for Biopharmaceuticals. FDA-Regulated Products. U.S. FDA Regulatory Information and Resources: Regulatory Intelligence. Regulatory Operations for FDA Applications. Summary on Regulatory Affairs Activities in Biotechnology Operations. Regulatory Compliance. Regulatory Compliance. Quality Systems to Meet Regulatory Compliance. Compliance for Biopharmaceuticals: Other Regulations of Importance. Quality Systems. Biomanufacture. Quality Control. Nonclinical Studies. Clinical Trials. Glossary. Additional Reading. Practical Problems and Questions

Catalog no. K11486, March 2011, 416 pp., ISBN: 978-1-4398-3027-7, $99.95 / £63.99 Also available as an eBook


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General Resources & Industry Applications

Healthcare Biotechnology

Intelligent Energy Field Manufacturing Interdisciplinary Process Innovations

A Practical Guide

Edited by

Dimitris Dogramatzis

Wenwu Zhang

Dogramatzis Pharmacy, Athens, Greece

"... particularly strong... provides insight into the biotechnology business sector." —British Journal of Biomedical Science

It is a mammoth task to bring a biotechnology innovation from inception to widespread therapeutic use. It takes strong managerial skills and a solid grounding in biopharmaceutical research and development procedures to foresee and plan for all of the possibilities and pitfalls involved. Healthcare Biotechnology: A Practical Guide focuses on the management of healthcare-related biotech—from product conception through regulatory approval and the rest of its life cycle. Divided into easily digestible sections, the book covers current systems, recent progress and controversy, major players and products, and comparisons with the pharmaceutical industry. Topics include: • Intellectual property protection and management • The innovation cycle • Patent application • Commercialization and competition • Funding • Partnering • Cash-intensive activities • Financing alternatives • Complexities of alliance implementation and management Highlighting research, development, and biomanufacturing, the book examines clinical trial design and regulations, "fast-track" approvals, and patient recruitment as well as production platforms and processes, costs, strategies, and timelines. The author investigates marketing, including planning, promotion, pricing, supply chain management, and bio-brand lifecycle management. He concludes with tips on running the business, offering diverse biobusiness models and reasonable expectations, from inception through maturity and decline. Catalog no. K12108, December 2010, 689 pp. ISBN: 978-1-4398-4746-6, $104.95 / £66.99

GE Global Research Center, Schenectady, New York, USA

An in-depth introduction to Intelligent Energy Field Manufacturing (EFM), this book explores a fresh engineering methodology that not only integrates and but goes beyond methodologies such as Design for Six Sigma, Lean Manufacturing, Concurrent Engineering, self-assembly, biometics, and more. It discusses dynamic M-PIE flows, the generalities of energy fields, logic functional materials and intelligence, the open scheme of intelligent EFM implementation, and the principles of intelligent EFM. Catalog no. 71017, July 2010, 728 pp. ISBN: 978-1-4200-7101-6, $159.95 / £99.00 Also available as an eBook

Drug Device Combination Products Delivery Technologies and Applications Edited by

A. Lewis Biocompatibles, UK Limited, Farnham, Surrey

Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive novel product development. Illustrating how effective drug delivery can be achieved by means other than oral tablets, this book provides a thorough analysis of the fundamentals, applications, and new technologies of drug-device combination products for use throughout the human body. The book discusses product development and areas of application. Catalog no. N10136, January 2010 ISBN: 978-1-4398-2479-5, $244.99 / £155.00

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General Resources & Industry Applications New Edition of a Bestseller!

Fundamentals of Microfabrication and Nanotechnology Third Edition (Three-Volume Set) Marc J. Madou University of California, Irvine, USA

Thoroughly revised and updated, this perennial bestseller lays the foundation for comprehensive theoretical and practical understanding of MEMS and NEMS. Expanded to three volumes to reflect the substantial growth in the field, this edition features recent developments in nano- and micromanufacturing techniques, DNA and protein arrays, fluidics, photonics, and actuators. Illustrated in color throughout, the text includes endof-chapter problems and worked-out examples, with many culled from recent literature and the author’s own work. Ancillaries are available upon qualifying course adoption.

Features • Features recent developments in nano- and micromanufacturing techniques, DNA and protein arrays, fluidics, photonics, and actuators • Provides theoretical foundation for understanding the science behind MEMS and NEMS • Explores the latest manufacturing techniques, including rapid prototyping and a wide variety of novel nanomanufacturing approaches • Offers thorough coverage of Bio-MEMS and Bio-NEMS • Contains worked-out example problems and end-of-chapter problems • Includes color illustrations integrated throughout the text

Catalog no. 3180, August 2011 1992 pp., ISBN: 978-0-8493-3180-0, $249.95 / £159.00

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General Resources & Industry Applications Also available as individual volumes Solid-State Physics, Fluidics, and Analytical Techniques in Micro- and Nanotechnology Selected Contents: Historical Note: The Ascent of Silicon, MEMS, and NEMS. Crystallography. Quantum Mechanics and the Band Theory of Solids. Silicon Single Crystal is Still King. Photonics. Fluidics. Electrochemical and Optical Analytical Techniques. Catalog no. 55119, June 2011 656 pp., ISBN: 978-1-4200-5511-5, $99.95 / £63.99 Also available as an eBook

Manufacturing Techniques for Microfabrication and Nanotechnology Selected Contents: LITHOGRAPHY: Photolithography. Next-Generation Lithographies and Lithography Research. PATTERN TRANSFER WITH SUBTRACTIVE TECHNIQUES: Dry Etching. Wet Chemical Etching and Wet Bulk Micromachining—Pools as Tools. Thermal Energy-Based Removing. Mechanical Energy-Based Removing. PATTERN TRANSFER WITH ADDITIVE TECHNIQUES: Physical and Chemical Vapor Deposition—Thin Film Properties and Surface Micromachining. Chemical, Photochemical and Electrochemical Forming Techniques. Thermal Energy-Based Forming Techniques—Thermoforming. Micro-Molding Techniques—LIGA. Catalog no. 55194, June 2011 670 pp., ISBN: 978-1-4200-5519-1, $99.95 / £63.99 Also available as an eBook

From MEMS to Bio-MEMS and Bio-NEMS Manufacturing Techniques and Applications Selected Contents: FROM TRADITIONAL MANUFACTURING TO NANOTECHNOLOGY: Nonlithography-Based (Traditional) and Lithography-Based (Nontraditional) Manufacturing Compared. Nature as an Engineering Guide Biomimetics. Nanotechnology: Top-Down and Bottom-Up Manufacturing Approaches Compared. Packaging, Assembly, and SelfAssembly. Selected Materials and Processes for MEMS and NEMS. Metrology and MEMS/NEMS Modeling. SCALING LAWS, ACTUATORS, AND POWER AND BRAINS IN MINIATURE DEVICES: Scaling Laws. Actuators. Power and Brains in Miniature Devices. MINIATURIZATION APPLICATION: MEMS and NEMS Applications. Catalog no. 5516X, June 2011 650 pp., ISBN: 978-1-4200-5516-0, $99.95 / £63.99 Also available as an eBook

Solutions manual, PowerPoint lecture slides, and electronic figures available upon qualifying course adoption.

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