Nrf2 Pathway
DUO SYNERGIZERS
Diabetes Health Fair Clearwater Bioacoustic Wellness Center Oxidative stress plays a major role in the pathogenesis of
Protandim Nrf2 & Nrf1 Synergizers effectively reduce oxidative stress and support mitochondria production to fight the effects of aging. www.clearwaterbioacoustic.com BENEFITS
Reduce oxidative stress*
Combat the effects of aging caused by oxidative stress*
Activate Nrf2 protein to turn on natural antioxidant production*
Repair and rejuvenate damaged cells*
Protect cells from free radical damage*
Create new mitochondria and increases the size of mitochondria*
Increase cellular energy (ATP)*
Promote cellular repair*
Enhance daily performance and energy levels*
Boost cellular health so that cells function at peak performance*
Reverse cellular aging by targeting genes to support chromosome maintenance*
both types of diabetes mellitus. Impairment in the oxidant/antioxidant
equilibrium creates a condition known as oxidative stress. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance.
Nrf2 mediates the induction
endogenous antioxidant and
signaling pathway are
of antioxidant genes and is a
detoxification systems.
aberrant in diabetes.
major regulator of the
Multiple aspects of the Nrf2
Mitochondria & Diabetes Nrf1 Pathway Mitochondria are critically
maintaining cellular
involved in the
homoeostasis, normal organ
pathophysiology of diabetes.
development and growth
Insulin release is regulated by
during life processes depend
mitochondrial ATP
on Nrf1. Conversely,
production and mitochondrial
dysfunction of Nrf1 may
ROS, or free radical damage,
result in a myriad of possible
may contribute to the long-
diseases.
term deterioration of insulin secretory capacity seen in type 2 diabetes. Moreover, ROS, appear important in the autoimmune destruction that characterizes type 1 diabetes, as well as in the pathophysiology of the longterm complications that characterize both classes of diabetes. Nrf1 specifically regulates pathways in lipid metabolism, amino acid metabolism, proteasomal degradation, the citric acid cycle, and the mitochondrial respiratory chain. Essential functions for
Mitochondrial ATP production is the main energy source for the cell. Diabetes reduces the efficient generation of ATP. Adenosine triphosphate play an essential role in glucoseinduced insulin secretion from pancreatic β-cells.
*These statements have not been evaluated by the Food and Drug Administration. This product/service is not intended to diagnose, treat, cure, or prevent disease.
Joseph Phillips & Cassie Dunn Clearwater Bioacoustic Wellness Center 702.575.3445 clearwaterbioacoustic@gmail.com www.clearwaterbioacoustic.com