How to Increase Effectiveness of Sildenafil for Erectile Dsyfunction Treatment

How does Sildenafil work to treat ED?

Sildenafil falls into a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. These inhibit phosphodiesterase enzymes, which degrade the molecules that relax the muscle tissue. This allows for increased blood flow, causing an erection. An important factor in sildenafil working properly is sexual stimulation. Sexual stimulation results in the release of nitric oxide, activating the enzyme guanylate cyclase and making increased cGMP levels possible.

Sildenafil does not cure ED. However, it can help treat the symptoms of the condition.

One study of the use of Sildenafil for treating ED states that the treatment is highly effective with a "good safety and tolerability profile in men with ED." The worldwide prevalence of ED is currently increasing, with an expected 322 million men being affected by 2025, according to a 2022 report on erectile dysfunction statistics.