CIDICS Science for our Society by CIDICS UANL

CIDICS

Science for our Society

CIDICS

Science for our Society Carlos Eduardo Medina-De la Garza Dora Elia Cortés-Hernández

UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN

Jesús Ancer-Rodríguez President Rogelio G. Garza-Rivera VicePresident of Administration Juan Manuel Alcocer-González VicePresident of Academics Mario César Salinas-Carmona VicePresident for Research, Innovation and Graduate Studies Rogelio Villarreal-Elizondo VicePresident of Cultural Affairs Carlos E. Medina-De la Garza Director of CIDICS Celso José Garza-Acuña Publishing Director St. Padre Mier # 909 Monterrey, Nuevo León, México, 64000 Phone (5281) 8324 4111 / Fax (5281) 8329 4095 e-mail: publicaciones@uanl.mx web page: www.uanl.mx/publicaciones First edition, 2013 Universidad Autónoma de Nuevo León © Carlos Eduardo Medina-De la Garza © Dora Elia Cortés-Hernández ISBN: 978-607-27-0179-3 All rights reserved according to the law. Prohibited the total or partial reproduction of this text without prior authorization. Impreso en Monterrey, México Printed in Monterrey, Mexico

For this book: Carlos E. Medina-De la Garza Dora Elia Cortés-Hernández Editors Daniela Azpilcueta-Salinas José Gerardo Velasco Castañón Co-editors Eloy Cárdenas-Estrada Felipe Edmundo Garza-García Collaborators Claudia G. Hernández-Rodríguez Mario Valles-Ballesteros Images & Photography

Content Introduction 9 Message of Rector 11 Message of Director 13 Background & Concept 15 Biosafety Office 17 Research Units 19 Gene and Cell Therapy 21 Influenza and Respiratory Pathogens 29 Emerging Pathogens and Vectors 35 Health Psychology 41 Public Health Research 47 Neuroscience 55 Immunomodulators 75 Health Education Nursing 81 Integral Dentistry 89 Bio-Modelling 101 Bioimaging 109 Molecular Biology, Genomics and Sequencing 111 Knowledge Management 127 Bioethics 133 Vaccinology / Clinical Studies 141 Tissue Engineering 143 CIMAT Monterrey 145 Academic, Educative & Outreach Projects 147 Human Variome Project (HVP) – México 149 Businesses and R&D 151 Science in Motion at CIDICS-UANL 153 National Week of Science and Technology (SNCyT) 155 Ibero-american Network for Communication and Health 157 Divulgation of Science and Biotechnology 159 Information and Data Sharing Technology 161 MEDICA 163 National & International Networking 165 Publications 166 Events & Seminars 173 Staff 177 Gallery 181 Art in CIDICS 195

Introduction

Message of Rector The Universidad Aut贸noma de Nuevo Le贸n (UANL), has established itself as the strongest research institution in northern Mexico, through 80 years with a solid structure and academic quality. The UANL takes the challenge to create a culture based on scientific and technological development. With relevance and quality on its educational programs, UANL is fundamental for sustainable development of our society. To create knowledge means creating opportunities, development and wealth. The project to improve knowledge to service our community, seeks to integrate scientific research on health sciences through the Center of Research and Development in Health Sciences (CIDICS), which is a project conceived and executed according to UANL priorities. CIDICS provides an academic infrastructure and research in fundamental areas of development as health, biomedicine and biotechnology. For the year 2013, 80 years after its beginning as a Public University, UANL has 34 Research Centers, ranging from areas such languages and software, to Aeronau-

tics and Biotechnology. With more than 560 professors belonging to the National Researchers System (SNI from CONACYT) and more than 1200 professors with the PROMEP-profile acknowledgement (from Education Ministry) UANL has the research and academic strength to continue in its quest to become the best university in Mexico. With our 2020 development plan as a tool and guide, we seek to meet our goal to be always a socially responsible, internationally recognized institution and thus serve the educational and developmental requirements and expectations of our state and country.

Jes煤s Ancer-Rodr铆guez Rector of UANL 11

Message of Director The Center for Research and Development in Health Sciences (CIDICS) is a project that was born as an idea at the beginning of year 2000 and became real with the dedication of its physical building on 29 September 2009. It was conceived by our current rector Dr. Jesus Ancer Rodriguez during his tenure as dean of medical school, with the aim to foster interdisciplinary, problemsolving oriented research.

CIDICS aims to be a sustainable facility and has developed bonds and collaborative work with industry and government offices which need and use data and information generated by our research units. We offer know-how in our areas of competence to those companies facing specific problems or seeking development of products, and also offer partnership and joint ventures to those interested in developing technology.

The concept of CIDICS is a high technology and high-performance facility where independent but integrated groups work together, which allows a broader understanding of specific tasks and problems and helps the development of an interdisciplinary problem-solving approach. Most of CIDICS scientist are professors of the different schools of UANL dealing with health, such as the medical school and University Hospital “Dr. José E. González”, Schools of Dentistry, Psychology, Nursing, and Public Health and Nutrition, to cite those located at the health sciences campus, home of CIDICS. We collaborate with and also nourish from our neighbors, the Center for University Health and the Outpatient Clinic for UANLWorkers. Additionally, other schools which collaborate with CIDICS are those of Biology, Chemistry, Veterinary Medicine, Agriculture, Technical High-School for Health, Mechanical Engineering and Law. Also of special meaning is our collaboration with schools such as the Communication College, which also have a desk and staff here for research and innovation in health and media and communication.

In its fourth year of operations, coinciding with the 80th anniversary of our University, we present this activity report to show who we are and what we do, in a simple and not overwhelming fashion, to help you get acquainted with our activities in order for you or your colleagues to find areas of interest. Please join us in this brief tour through CIDICS, we hope you will enjoy it!

Carlos E. Medina-De la Garza

Director of CIDICS

Background & Concept of CIDICS The construction of the Center started in December 2006, designed by Architect Oscar Leal-Garza and built by Engineer José Luis Martínez-Cuéllar. In the administration of works and operative tasks, many scientist and administrators collaborated, among others Dora Elia Cortés-Hernández, Ernesto Torres-López, Graciela Ramírez and Rosalinda Sepúlveda. In September 29, 2009 it was dedicated by the Governor José Natividad González-Parás and Rector José Antonio González-Treviño. The Secretary General of UANL and now Rector Jesús Ancer-Rodríguez was the driving force of the concept and its materialization. In February 2010 Dr. Rick A. Rogers was appointed Director and then in September 2010, Dr. Carlos E. Medina-De la Garza was appointed. Purpose of CIDICS is to establish the physical infrastructure and high level human resources that requires our national science. This project is so far unique in the region and corresponds to the concept of academic contribution to acknowledge-based economy. We develop tangible knowledge products and other technology-based companies.

CIDICS is a facility depending on the Central Administration of UANL and in the alignment with the Rectorat and the Vice-presidency for Research, Graduate Studies and Innovation. The Direction on charge of Dr. Carlos E. Medina-De la Garza has two main branches, the administrative, where MES. Felipe E. Garza-García is re sponsible, and the Academic under responsibility of Dr. Dora Elia Cortés-Hernández. The Direction team is also supported by Accountancy, Human Resources, and Public Relations Office, and by a well trained staff to allow the administrative duties to run smoothly. CIDICS will be soon undergoing a process for quality-management certification under the ISO 9001-2008 normative, to further warrant the ever-growing number of processes and activities that support all laboratories and research groups. The Direction of such a young center as CIDICS, nourishes from the ideas and innovation from all CIDICS members and scientific staff, and runs an open policy to foster innovative proposals and initiatives.

Biosafety Office The Biosafety Office (BO) is the area of Direction dealing with biohazards and all sort of internal biorisks affecting CIDICS in order to maintain a safe working environment. Its main purpose is to provide a theoretical an practical framework regarding both safety and security for perssonnel working at CIDICS. This is achieved in collaboration with all of the research unit heads. BO is also responsible for perssonel training and daly surveillance regarding occupational safety, as well as updating internal procedures to comply with federal, state and municipal regulations. Independent of BO but working in close collaboration, CIDICS has a Biosafety Committee to constantly evaluate research projects and keep a track on ongoing and upcoming legislation regarding Biosafety and Biosecurity issues.

Head of Biosafety Office EfraĂn Montes-Villarreal efrain.montesv@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1740

Research Units

Gene and Cell Therapy Unit This Unit goal is the research and development of innovative therapies for treatment of chronic degenerative diseases that severely affect quality of life. The Unit has equipment, infrastructure and trained scientific and technical personnel to develop products and services based on the application of knowledge and techniques of molecular and cell biology and biomaterials engineering. Our main research focus on development of oncolytic viral vectors for cancer and the combination of gene therapy and methods for generating cell implants for bone and joint injuries. Additionally, we are engaged on adult multipotent cell research for vascular- and tissue- regeneration. We have projects funded by CONACYT (National Council for Science and Technology, Mexico) and international agencies such as UC-MEXUS and the Seventh Framework Programme of the European Economic Community, and collaborate with the NIH, USA and the University of Bonn, Germany. Through graduate programs in Basic Sciences from the Faculty of Medicine of UANL, our unit supports the training of highly specialized scientists, for preclinical and early phase clinical studies.

Head of Gene and Cell Therapy Unit Augusto Rojas-MartĂnez augusto.rojasm@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1751

Stem Cells and Bone: enhanced healing Among adult human tissues, bone is unique because its remarkable regenerative potential which declines with lifespan. Still, in some circumstances external bone materials are required for extensive reconstructive or corrective surgeries of fractures, craniofacial malformations, periodontal disease, etc. Sometimes, bone material is either scarce or inaccessible. As an alternative, in a collaboration with the Bone and Tissues Bank of the University Hospital and the Department of Biochemistry and Molecular Medicine of the School of Medicine, UANL, we developed a 3-component implant (3CI) made with genetically modified mesenchymal stem cells (MSC) expressing the morphogenetic proteins 2 and 7 (BMP2 and BMP7) and embedded in a demineralized bone matrix. In vitro assays demonstrate that the 3CI is composed of osteoblast able to produce a matrix of collagen 1 plus key bone constitutive proteins like osteocalcin, osteopontine, etc. This implant also demonstrated improved bone repair with the 3CI implant in around 10 weeks in dog and sheep, animal species selected as big mammal models for prospective clinical trials. These studies also confirmed the presence of cortical and marrow bone structures in 3CI implanted animals, which also displayed mechanical properties resembling those of the intact mature bone.

Castro-Govea Y, et al. Human bone morphogenetic protein 2-transduced mesenchymal stem cells improve bone regeneration in a model of mandible distraction surgery. J Craniofac Surg. 2012. 23:392396. Hernández-Hurtado A, et al. Stem cell-derived Implant for bone replacement tested in complete tibia osteotomy in the sheep. In preparation. 2013. Patent application: Implante de células madre mesenquimatosas autólogas modificadas genéticamente para regeneración ósea y método para la reproducción del mismo. MX/a/2008/DI6103. IMPI

Stem Cells helping cartilage regeneration Lesions of the major joints represent a growing health problem claiming alternative therapeutic approaches, due to restrictions in the natural regenerative potential of the hyaline cartilage. Mesenchymal stem cells (MSC) have an intrinsic chondrogenic potential to alleviate tissue demands and research groups world-wide are actively working to generate cartilage implants closely resembling the unique features of the natural cartilage. In collaboration with the Bone and Tissues Bank of the University Hospital and the Department of Biochemistry and Molecular Medicine of the School of Medicine, UANL, we are developing a precultured implant constituted by genetically modified MSC expressing insulin-like factor 1 (IGF1) and fibroblast growth factor 2 (FGF2) and embedded in a cartilage-derive scaffold. In vitro assays demonstrate that the 28-days cultured implant transduced with adenoviral vectors expressing the referred growth factors is able to produce hyaline tissue mainly composed by a matrix rich in collagen 2 and cartilage proteoglycans, like aggrecan, byglycan, cartilage matrix protein, etc. we are currently working in an ovine preclinical model of knee lesions to test the efficacy and safety of this implant.

Garza-Veloz I, et al. Analyses of Chondrogenic Induction of Adipose Mesenchymal Stem Cells by Combined Co-stimulation Mediated by Adenoviral Gene Transfer. Arthritis Research & Therapy. 2013. 15: R80 Figure: Histologic and IHC (anti-collagens II, I, and X) analyses of cartilage microspheres generated by MSC transduced with several combinations of genes for chondrogenic factors after 14 and 28 days of culture. IGF1/FGF2 cotransduced microspheres resembled the proteoglycan composition of the hyaline cartilage, the acceptable expression of collagen II and the restricted presence of collagens I and X.

Gene Therapy for Cervicouterine and Prostate Cancer Tumors display unique features that distinguish them from others. Cervicouterine cancer (CUC) is 99% associated to human papillomavirus (HPV) infection. This virus takes advantage of specific transcription factors expressed in the cervical microenvironment to support its own replication. Despite recent demonstrations rejecting the pathogenic role of the xenotropic murine leukemia virus (XMRV) in prostate cancer (PC), this γ-retrovirus is able to transduce prostate tissue. We are working in the design, construction, and production of adenoviral and retroviral vectors for cancer gene therapy. We developed conditionally replicating adenoviral vectors for CUC, considering that these tumors are HPV positive and overexpress the transcription factor Brn3a. The oncolytic adenoviral vectors Ad5-URR∆24 (patented) and Ad5-UV2∆24 contain modified versions of the HPV16-promoter region to drive vector replication in HPV-infected and Brn3a-expressing cells, respectively. Both vectors contain the ∆24 deletion in the E1A gene to restrict their genetic functions to tumor cells with disrupted pRB-control of the cell cycle. The Ad5-URR∆24 effectively controls tumor growth and extended survival in a mouse model of CUC.

We also developed a retroviral system based on XMRV genome for PC. The system includes the gene-carrier plasmid, the XMRV non-replicating genome plasmid, and the packaging cell line.

Delgado-Enciso I, et al. A potent replicative Delta-24 adenoviral vector driven by the promoter of HPV-16 that is highly selective for HPVassociated neoplasias. 2007. Journal of Gene Medicine 9:852-861. Cervantes-García D, et al. Oncolytic virotherapy. Annals of Hepatology. 2008; 7:34-45. Delgado-Enciso I, et al. Evaluación preclínica del efecto terapéutico de vectores adenovirales en neoplasias dependientes del papilomavirus humano. Rev Invest Clin 60:101-106. 2008. Cervantes-Garcia D, Rojas-Martinez A, Camerini D. An XMRV derived retroviral vector as a tool for gene transfer. Virol J.2011; 8:284. Vectores adenovirales de replicación selectiva dirigida por el promotor URR de virus de papiloma humano y deficientes en funciones de E1A. Patent title: IMPI 287339 (Mexico). 2011. Figure: In vivo antitumor effects of Ad-URR/E1A∆24. A. Tumor growth curves of female mice bilaterally implanted in the dorsum with human HVP tumor lines HeLa and SiHa. Only left tumors were injected with vector and mock treatments. Ad-URR/E1A∆24 effectively controlled tumor growth in mice implanted with the two different lines. B. Survival curves also demonstrates difference between the Ad-URR-E1A∆24 treated mice and the remaining controls.

Influenza and Respiratory Pathogens Laboratory Our Laboratory has established a collaborative interdisciplinary work in order to monitor epidemiological acute respiratory diseases; clinics participating in this University Health Center, which provides primary medical care to people living in an urban area in the municipality of Guadalupe, NL. Throat swab samples where collected from people suffering IRA during the period September 2011 to March 2012. The throat swab specimens allowed the detection of pathogenic viruses, among which monitoring influenza A/H1N1 2009 virus by RT-PCR thus contributes to study antigenic changes posed by these viruses this is an activity in collaboration with the Global Influenza and Surveillance Response System (GISRS) sponsored by the World Health Organization, as an effort aimed at reducing morbidity and mortality from epidemics caused by influenza virus and have programs and supplies in preparation for the next pandemic. Studies on accute respiratory infection dynamics are fully supported through collaboration with Centro de Investigaciones en Matematicas (CIMAT).

Head of Influenza and Respiratory Pathogens Laboratory José Gerardo Velasco-Castañón jose.velascoc@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1761

Relationship between Acute Respiratory Illnesses and Weather Studies on Acute Respiratory Infection (ARI) are of utmost importance as these maladies constitute the most frequent cause to seek medical attention in any given country. ARI´s are a group which includes diferent syndromes and assorted aetiologies among which viruses and particularly influenza stand out; the later exhibits an ample antigenic variability that enables the periodic occurrence of severe epidemics and pandemics such as the ones in 1918, 1957, 1968 and 2009. Whilst most published data on ARI addressing the impact on human health in more than 8 decades are derived from studies about specific pathogens or hospitalized patients, here at CIDICS we have adopted an integral strategy to approach Epidemiology of all ARI cases as defined in the International Statistical Classification of Diseases and Related Health Problems. This is accomplished through a time series statistical model that can lead to develop a real time monitoring system linked to a Global Positioning System. This epidemiological approach is posible through CIDICS ongoing collaboration with Centro de Investigaciones en Matamáticas (Unidad Monterrey), as well as Centro Universitario de Salud, the Immunology Department, Facultad de Medicina and Secretaria de Salud del Estado de Nuevo León.

Costilla-Esquivel A, Corona-Villavicencio F, Velasco-Castañón JG, Medina-De la Garza CE, Martínez-Villarreal RT, Cortes-Hernández DE, Ramírez-López LE, González-Farías G. A relationship between acute respiratory illnesses and weather. Epidemiol Infect. 2013. 2:1-9 Figure: Google Maps

Influenza and Acute Respiratory Infection (Ari) Watch Respiratory tract infections belong in the group of very important infections in children and adults. One third of all infection-related hospitalizations are due to respiratory tract infections. Upper respiratory tract infections are one of the most significant reasons for school or work absenteeism. These group of diseases that affect the air passages, including the nasal passages, the bronchi and the lungs are generally benign, nevertheless, the disease burden for Acute Respiratory Infections (ARI) is estimated at 94 037 000 DALYs (WHO, 2002 ) and 3.9 million deaths (WHO, 2002 ). ARI are among the leading causes of death in children under 5 years but diagnosis and attribution are difficult and uncertain. Most cases of ARI syndrome can be attributed to a number of very diferent ethiological agents, like Influenza, Parainfluenza Respiratory syncytial virus, , Adenovirus, Coronavirus, Rhinovirus as well as bacteria such as: Streptococcus pneumoniae and Haemophilus influenzae, thus early detection of epidemics and pandemics is stressed in World Health Organization sponsored Global Influenza Surveillance and Response System (GISRS), which has been successfully functioning for over half a century.* We at CIDICS have established a permanent follow up on both national and international epidemiological data and recomendations on Influenza.

This effort is carried out in collaboration with The State of Nuevo Le贸n Health Ministry (Secretaria de Salud del Estado de Nuevo Le贸n). Contents consists of data published in scientific literature and Public Health recommendations and guides directed to Health Professionals as well as public at large. Our permanent activities would help in proper allocation of resources such as vaccine distribution and public health education campaigns, or decrease unnecessary antibiotic use for acute respiratory tract infections in adults in a point-of-service health care level.

http://www.who.int/influenza/gisrs_laboratory/en/index.html *Pan American Helath Organization RESOLUTION CSP27.R10. Regional policy and strategy for ensuring quality of health care, including patient safety

Emerging Pathogens and Vectors Unit Emerging and re-emerging vectorborne diseases encompass those pathologies currently threatening the public health grounds in most developing countries. Global warming changes, increase in human population migration and intense traffic among animal health, wildlife disease, and public health pathogens are responsible to modify the rural and urban environment and so to facilitate spreading worldwide of above mentioned diseases. This Unit is formed by professors of the Biology and Medical school, comprising departments of those, such as infectology, biochemistry and entomology. The Unit of Emerging Pathogens at CIDICS plays a key role in surveillance and alerting to local and regional Health authorities introduction of new human disease agents. Likewise, study and research on emerging vector-borne diseases is stimulated throughout frequent seminars, writing of grant proposals for funding, and supporting undergraduate and graduate students thesis offered to different University schools such as Medicine, Biology, Veterinary Science, and Public Health. Current research topics considered in this Unit are: Dengue, Rickettsia, West Nile Virus, Arboviruses and Filarial vectors.

Head of Emerging Pathogens and Vectors Unit Ildefonso Fernรกndez-Salas ildefonso.fernandezsl@uanl.edu.mx +52(81)1340-4370 / 8329-4000 ext. 1789

Dengue-Infected Vectors As Surveillance Tool The detection and serotyping of dengue viruses in mosquitoes in endemic and epidemic areas is of critical importance. During epidemic periods, these studies can identify areas where transmission of dengue virus is greatest, thereby allowing vector control authorities to prioritize their efforts and focus on areas where individuals are at greatest risk of disease. During endemic periods, mosquito-based dengue virus surveillance provides an early warning system for predicting future dengue outbreaks, therefore allowing for the timely implementation of prevention and control measures. To identify the dengue virus serotype(s) temporally and spatially associated with the cases, entomologic-based virus surveillance was initiated. Adult mosquitoes were collected from 88 houses by CDC backpack aspirator, and all female Aedes aegypti L. (n = 419) were individually homogenized and assayed in pools by (RT-PCR). Five(12%) of 41 pools were positive for dengue virus-RNA. The individual mosquitoes essays produced six mosquitoes positive for dengue virus serotype-2 (DENV-2) RNA.

Sánchez-Casas RM, Alpuche-Delgado RH, Blitvich BJ, Díaz-González EE, Ramírez-Jiménez R, Zarate-Nahon EA, Sánchez-Rodríguez OS, Laguna-Aguilar M, Marcela Alvarado-Moreno M, Ibarra-Juárez LA, Medina-de la Garza CE, Lorono-Pino MA, Marco Domínguez-Galera M, Mis-Ávila P, Fernández-Salas I. Detection of Dengue Virus Serotype 2 in Aedes aegypti in Quintana Roo, Mexico, 2011. Southwestern Entomologist. 2013; 38(1):109-117. Image: Copyright Dr. Leonnnard Munstermann, University of Notre Dame, USA

Surveillance of West Nile Virus in the USA-Mexico border The Emerging Pathogens Unit maintains since several years a surveillance program on West Nile Virus (WNV). It intends to define the role of vertebrate hosts; i. e., resident and migratory birds and horses, as well as mosquito vectors, into the zoonotic transmission disease dynamics of West Nile Virus (WNV), an emerging disease one decade ago introduced into Mexico. These viruses are usually maintained in cycles between mosquito vectors and avian reservoir hosts. The principal vectors for WN virus are Culex mosquito species, although various Aedes, Anopheles and Ochlerotatus species are also involved in transmission cycles. Many different wild bird species act as reservoir hosts. Humans and horses are usually incidental hosts, and clinical manifestations include fever, fever with aseptic meningitis, or fever with encephalitis. The detection of WN virus infections in animals often precedes the first reports of human disease. Our group has also documented the last years, virus isolation from horse brains, Culex mosquitoes, seropositive resident and migratory birds as well as human cases in northeast Mexico states. WNV diagnosis is conducted throughout field collections and hospitals, it includes blocking ELISA, RT-PCR and sequencing of isolated virus.

Rodríguez MdeL, Rodriguez DR, Blitvich BJ, López MA, FernándezSalas I, Jimenez JR, Farfán-Ale JA, Tamez RC, Longoria CM, Aguilar MI, Rivas-Estilla AM. Serologic surveillance for West Nile virus and other flaviviruses in febrile patients, encephalitic patients and asymptomatic blood donors in northern Mexico. Vector-Borne and Zonnotic Diseases. 2010; 10(2): 151-157 Fernández-Salas I., J. F. Contreras-Cordero, B. J. Blitvich, J. I. González-Rojas, A. Cavazos-Álvarez, N. L. Marlene, A. Elizondo-Quiroga, M. A. Loroño-Pino, D. J. Gubler, B.C. Cropp, Ch. H. Calisher, B. J. Beaty. Serologic evidence of West Nile Virus infection in birds, Tamaulipas State, México. Vector-borne and Zoonotic Diseases. 2003; 3(4):209213.

Health Psychology Unit The unit of health psychology is organized in the following areas: Sleep Laboratory studies different sleep habits and disorders that affect the quality of the physical and psychological functioning, as well as their relationship with medical and psychological variables. Psychooncology studies psychosocial factors that favor the development of different types of cancer, evaluate the emotional impact on the patient and family. It also addresses medical treatment adherence and behaviors, emotions and social factors that favor the survival of this condition. Research in addictions aims to develop explanatory models and integrative multidimensional about psychosocial problems (school violence, suicidal ideation, etc.) in order to create comprehensive programs for health promotion, prevention and treatment of these problems.

Head of Health Psychology Unit Arnoldo T茅llez-L贸pez arnoldo.tellez@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1768

Psychological Aspects In Breast Cancer Patients Psycho-oncology studies the evaluation and treatment of psychological processes altered by the diagnosis and treatment of cancer, such as stress, depression, low self-esteem, among others. These conditions along with sociodemographic characteristics affect the quality of life of breast cancer patients and their families. The Unit of Health Psychology along with professors from the Faculty of Psychology con ductstudies to determine the impact of these variables on the quality of life, where stress is one of the main factors involved, along with progressive deterioration of health in cancer. On the other hand, psychological variables such as high self-esteem, optimism, and social support can reduce the effects of stress and have a positive influence on breast cancer treatments, in which altered body image and sexual function have great influence and are major areas of study. Evaluation of interventions such as hypnotherapy to improve the quality of life and health of these patients, in addition to studying relationship between immune system cells, hormones such as cortisol and psychological aspects, are of paramount interest.

Moral-De La Rubia J, Segura-Herrera LG, García-García E, Téllez-López A. Estrés y calidad de vida relacionada con la salud en padres de niños con leucemia linfoblastica aguda. Psicogente. 2012; 15(18): 249261. Juárez-García, DM, Landero-Hernández R. Imagen corporal, funcionamiento sexual autoestima y optimismo en mujeres con cáncer de mama. Nova Scientia. 2011; 4: 17-34.

Sleep Disorders Sleep disorders appear in different populations, and instruments to measure for Spanish population are scarce or specific to certain disorders, so Unit Health psychology we took on the task of conducting a questionnaire for detection of different sleep disorders, count on validity and reliability. This questionnaire is based on the International Classification of Sleep Disorders and includes 30 items seeking detect insomnia, somnolence, snoring, sleep apnea, among other disorders. Currently this instrument is used to study the prevalence of sleep disorders in different populations as rotating shift staff, service users or general population health. The studies conducted at the sleep-facilities at CIDICS are focused also on shift workers and all those who are under stress and sleep deprivation. The Monterrey scale for sleep disorders is a new, valuable tool for their study.

Téllez-López A, Villegas-Guinea D, Juárez-García D, Segura-Herrera LG. Cuestionario Trastornos de Sueño Monterrey. Medicina Universitaria. 2012; 14(56): 150-156.

Public Health Research Unit The Unit of Research on Public Health is a specialized center that produces scientific knowledge applied to this field. The Unit has human and technological resources to carry out excellent qualitative and quantitative research, in the field as well as in the laboratory. It integrates highly trained and specialized multidisciplinary staff, and provides a space for postgraduate human resources development in any of the essential areas of public health. Its lines of generation and production of knowledge are oriented to the field of health promotion, healthy lifestyles, determinants of health, epidemiology, environmental health, health systems and services, health economics, public policy, and migration and health. Its projects are focused on infectious and priority chronic degenerative diseases prevalent at present, influenza, respiratory diseases, obesity, diabetes, and asthma. All with emphasis on the northern border region of Mexico.

Head of Public Health Research Unit Dora Elia CortĂŠs-HernĂĄndez dora.cortesh@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1753

Accidents and Road Safety The traffic accidents in Nuevo Leon during 2010 represented 17% of the global burden for traffic accidents in Mexico, a serious problem that concerns to public health. The mortality and disability for this cause, could be diminished by the adoption and implementation of preventive measures as the use of the safety belt and helmet for motorcyclists as well as to not to drive under the effects of alcoholic beverages. We try to foster the use of safety devices on motor vehicles. To support the implementation of public policies and governmental campaigns of prevention for accidents and road safety with scientific evidence, the Unit of Research on Public Health has developed in collaboration with the health services at Nuevo León, for 3 consecutive years gathering of baseline data in 4 municipalities of the metropolitan area to find out the prevalence of four risk factors related to accidents, finding in 32,622 surveys a media between 2010 and 2012 in the prevalence of the use of safety belt in drivers of 54.52 % and the use of infant car chairs was only 33.7 % . In addition, the incorrect use of helmet in motorcyclists resulted in a 46.4 % reflecting these results, the need to establish strategies and policies of promotion and prevention focus on these specific risk factors.

In collaboration with the State Secretariat of Health and the State Council of Accident Prevention of Nuevo Leon, two reports were published, aimed at municipalities decision makers, plus one bulletin for broad public distribution and a book addressing Accident profile in Nuevo León.

Informes de Resultados de Línea Basal y Seguimiento en Monterrey, San Pedro, Guadalupe y García. 2010, 2011 y 2012. Boletín del Consejo Estatal de Prevención de Accidentes, Nuevo León 2010; 1(1). Accidentes Viales en Nuevo León. Perfiles Estadísticos 2004-2010. Publicación del Comité de Vigilancia Epidemiológica del Consejo Estatal de Prevención de Accidentes en Nuevo León.

Spatial Clusters of infant mortality rates in Mexico The infant mortality is distinguished by substantial variations among regions, states, municipalities and also including rural and urban communities. More importantly the rates of infant mortality are not randomly distributed in the geography of a country and if it is widely correlated by the level of socioeconomic development. Infant Probability of Survival show spatial variations and conglomerations within the regions which can change in agreement to the place where they were born. In the search of local variations of spatial autocorrelation or spatial clusters the local statistic is estimated of I-Moran and the Local Index of Spatial Autocorrelation (LISA) which facilitates the identification of municipalities with high concentration, low concentration and spatial atypical concentrations. The map shows the distribution of four different spatial clusters: a) High-High (HH): a municipality with high values and also its neighbors, b) High - low (HL): a municipality with high values and neighboring with low values; c) Low - high (LH): a municipality with low values and neighboring with high values; d) Low - low (LL): a municipality with low values as well as its neighbors.

As it is shown in the figure above the spatial clusters of high values (HH) of rates of infant mortality are found in the south and south-east areas of Mexico covering sections of the states of Guerrero, Chiapas, Oaxaca and Veracruz as well as the Tarahumara regions of Chihuahua. In contrast the spatial clusters of low values the (LL) are specially found in some sections of the region of the north border and particularly in the center-west of Mexico a region with high tradition of international migration to the United States.

Flores M, Sunil TS, Picazzo-Palencia E, Cortes-Hernandez DE. A spatial analysis of the effects of international migration on infant mortality in Mexico. Social Development Issues. 2012; 32(2): 1-15. Map: Spatial Clusters of infant mortality rates in Mexico at municipal level, 2000.

Spatial Distribution of Hypertension in Adult Population of Mexico Hypertension is one of the principal causes of death and disability worldwide; though the strategies to prevention and control of the hypertension have been widely applied in many countries for more than 50 years the global rates of control of the arterial pressure continue to be low in most of the countries. Mexico finds itself in an advanced phase of the epidemiological transition with a disease burden dominated by the non-communicable diseases among them: heart diseases, brain hemorrhage and hypertension. This happens in spite of the advances in the universal coverage of health services in the country. To public health decision makers and epidemiologists, it is important to know the geographical distribution of hypertension in adult population, further as the prevalence, knowledge, treatment and control. Consequently with this information, the health authorities could focus the preventive and promotion strategies and programs looking for better impact and effectiveness. The geographical areas with higher prevalence rates of hypertension in adult population are the states of the north of Mexico among them: Sonora, Durango, Baja California Sur, and Coahuila including others.

On the other hand at the center-south area of the country, the states with a lower rate of prevalence are: Puebla, Guerrero, Oaxaca and Chiapas. It should be noted that two states of the north (Nuevo Le贸n and San Luis Potosi) possess very similar prevalence rates between them than those of the south-center region. It is important to highlight that Mexico City and the state of Morelos located in the central region show the highest rates of hypertension under control in Mexico.

Dora Elia Cort茅s Hern谩ndez, Esteban Picazzo Palencia. External cooperation: Jose Javier Sanchez, Jose R. Banegas. (Professors and researchers of Department of Public Health, Preventive Medicine and Microbiology, Faculty of Medicine of Universidad Aut贸noma de Madrid. Maps: Prevalence of hypertension, aware, treatment and control in adult population in Mexico, based on the National Survey of Health and Nutrition (ENSANUT) 2006.

Neuroscience Unit Understanding the underlying function of the nervous system is crucial for the study, diagnosis and treatment of neurological pathologies in humans. Scientific research of the healthy and diseased anatomy, physiology, biochemistry and genetic of the nervous system is of great importance to medicine, as this contributes to its continuous improvement. The Neuroscience Unit is a research group created by the Department of Neurology of the Faculty of Medicine and University Hospital UANL, that also includes researchers from the Department of Biochemistry and the Department of Pharmacology. Our main goals are to produce basic and clinical research knowledge of the nervous system, implement this research into the clinical setting, and train excellent human resources of all levels of biomedical research.

Coordinator of Neuroscience Unit Eduardo Garza-Villarreal eduardo.garzav@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1757

The Absolute Pitch Ability Absolute pitch (AP) is the remarkable ability to identify a musical pitch without an external sound reference. AP is often considered to reflect musical giftedness, but it has also been associated with certain disabilities due to increased prevalence of AP in individuals with sensory and developmental disorders. We are currently researching the cognitive processing of the AP ability in collaboration with the Center of Functionally Integrative Neuroscience of the University of Aarhus. One of our findings suggests that the AP ability may be directly related to autistic traits such as poor social skills and attention switching, although not to autism itself. We also found that musicians with AP have increased cortical thickness in many different areas of the brain related to auditory, language, memory and even visual processing, as well as increased white matter in association cerebral tracts. Hence, this is a very complex ability that seems to entail a widely distributed anatomical network. Finally, another novel finding was that the AP ability is partly practice-dependent. This means that people with AP benefit from practicing their ability and they can get better or worse at it with time, bringing up the long argument about nature or nurture.

At the moment, we are working on the brain anatomical correlates of the AP ability in the subcortical structures such as the hippocampus and the basal ganglia in collaboration with the Kimel Family Translational Imaging Genetics Research Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health Department of Psychiatry, University of Toronto, Canada, as well as the cognitive processing of AP measured by electroencephalography.

Garza-Villarreal EA, Dohn A, Chakravarty MM, Hansen M, Lerch J, Vuust P, “Gray and white matter anatomy of absolute pitch possessors”. In review in Cerebral Cortex Dohn A, Garza-Villarreal EA, Heaton P, Vuust P. “Do Musicians with Perfect Pitch Have More Autism Traits than Musicians without Perfect Pitch? An Empirical Study”. 2012. PLoS ONE, 7(5), e37961. Dohn A., Garza-Villarreal E. A., Ribe L. R., Wallentin M., Vuust P. “Musical Activity Tunes Up Absolute Pitch Ability”. In review in Music Perception. Image by Eduardo A. Garza-Villarreal

Can Sounds Reduce Pain? Placebo Analgesia of Auditory Stimuli Pain is a very complex entity related to damage or disease. It involves somatosensory, emotional and cognitive processing to name a few, and we are nowhere near on understanding how pain and analgesia are processed. Placebo analgesia is the analgesic effect of an innocuous treatment such as a sugar pill. Studies have shown that there are several opiate and dopaminergic pathways related to placebo analgesia, suggesting that it is a physical effect where cognitive and emotional mechanisms play a key role. It is fairly known that some auditory stimuli, such as music, can reduce acute and chronic pain. In previous studies we showed that any auditory stimulus, nature sounds or music, reduce acute pain when it is pleasant and relaxing. But also, we have shown that the thought that the auditory stimulus will reduce pain is enough to reduce it. We are currently trying to uncover if auditory stimuli can elicit a placebolike analgesia, similar to the placebo effect observed with innocuous sugar pills, and if this effect can be use successfully as a treatment adjuvant in central pain diseases such as fibromyalgia. This is a project in collaboration with the Center of Functionally Integrative Neuroscience of the University of Aarhus and the Institute of Neurobiology of the Universidad Nacional Autónoma de México, where we performed behavioral and functional magnetic resonance imaging (fMRI) methods to study the analgesic effect of auditory stimuli.

Garza-Villarreal EA, Wilson AD, Vase L, Brattico E, Barrios F, Jensen TS, Romero-Romo JI, Peter Vuust. Music reduces pain and increases functional mobility in fibromyalgia. In preparation for Journal of Pain. 2013. Garza-Villarreal EA, Brattico E, Vase L, Østergaard L, Vuust P, “Superior analgesic effect of an active distraction versus pleasant unfamiliar sounds and music: the influence of emotion and cognitive style”. PLoS ONE. 2012; 7 (1), e29397. Garza-Villarreal EA, Brattico E, Leino S, Ostergaard L, Vuust P. “Distinct neural responses to chord violations: A multiple source analysis study”. Brain research. 2012; 1389: 103–114. Image source: http://www.sxc.hu

Importance of Lipid on Neuronal Plasticity Induced by Drug Addiction Drug addiction is a severe neuropsychiatric disorder characterized by loss of control over reward (associated with pleasure) motivated behaviour. This behaviour is controlled by a set of brain structures, “the rewarding system”, organized to direct behaviour towards goals that are beneficial to the organism to survive (e.g., food and water intake and reproductive activities). Abuse of drugs has been demostrated to stimulate the rewarding system inducing aberrant neuronal plasticity, which disrupt the system and impair all rewarded motivated behaviour because avoid the capability of the system to suffer future synaptic plasticity. We are studying the mechanism that lead to disruption of rewarding system in animal models. Previously, our investigations have showed that lipids are important in the regulation of synaptic proteins, especially during plasticity. At present, our research is focused on the role of lipids and glutamate receptors on synaptic plasticity induced by addictive drugs. Our aim is to identify alteration that may suffer glutamate receptors and to determinate whether manipulation of membrane lipids could attenuate or revert these alterations in a animal model.

Delint-Ramirez I, Willoughby D, Hammond GV, Ayling LJ, Cooper DM. Palmitoylation Targets AKAP79 Protein to Lipid Rafts and Promotes Its Regulation of Calcium-sensitive Adenylyl Cyclase Type 8. J Biol Chem. 2011; 286(38):32962-75. Delint-Ramirez I, Fernandez E, Bayes A, Kicsi E, Komiyama NH, Grant. SGN. In vivo composition of NMDA receptor signalling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93. The Journal of Neuroscience, 2010. 30(24):8162-8170. Delint-Ramírez I, Salcedo-Tello P, Bermudez-Rattoni F. Spatial memory formation induces recruitment of NMDA receptor and PSD-95 to synaptic lipid rafts. (2008). J Neurochem. Aug 2008, 106(4):165868. Image by Ilse Delint-Ramírez

Role of Glutamate Receptors in Food Addictions and Obesity Mounting evidence suggests that overeating may be conceptualized within the same behavioural and neurobiological framework as drug addiction. Neural circuits implicated in drug conditioning, craving and relapse overlap extensively with those involved in natural reward and reinforcement like food. Moreover, both psychoactive substances and palatable food induce release of dopamine following acute ingestion or administration in the rewarding system. While dopamine is in large part responsible for reinforcing the acquisition of drug seeking behaviours, considerable evidence indicates that disruptions in glutamatergic neurotransmission are responsible for chronic, long-lasting drug seeking behaviours. It has been reported that chronic cocaine administration decrease metabotropic glutamate receptors (mGLUR1 and 5). This promotes alteration of other glutamate receptors increase of AMPA and decrease of NMDA receptors which has been related with the loss of capability of the rewarding system to recover and return to basal levels, still after long withdrawal period. However, glutamatergic system in food addictions and obesity has been studied very little. This is way our research is focused on determinate whether palatable food can induce alteration on glutamate receptors that has been reported for drug addictions.

At the moment we have observed that obese mice (which were fed with high fat diet for 3 months) had alteration in the levels of synaptic NMDA receptors. Now we are standardizing a model to induce and measure food addiction in mice. Using this model we are going to determinate whether food addictions induce changes in glutamate receptors in synapses. Next step will be design strategies to manipulate the glutamatergic system with the objective of regulate palatable food ingestion in food addiction and obesity.

Delint-Ramirez I, Camacho-Morales A, Segoviano-RamĂrez JC, GarzaVillarreal, EA. Role of glutamate receptors in food addictions and obesity. In preparation.

Hypothalamus and Type 2 Diabetes Positive energy balance during obesity lead to metabolic complications including type 2 diabetes. The role of central nervous system in the coordination of energy balance has been proposed as an attractive candidate to become deleterious during obesity. Our research focuses on determining the molecular mechanisms of how the excessive increase in fat food intake affects the physiology of the hypothalamus, a brain structure that coordinates the bodyâ&#x20AC;&#x2122;s energy balance, insulin sensitivity and diabetes susceptibility. Also, we study, whether manipulating these mechanisms it would be possible to prevent or reverse metabolic abnormalities associated with diabetes.

Camacho-Morales A, Delint-Ramirez I, Segoviano-RamĂrez JC, GarzaVillarreal EA. Mechanisms of hypothalamic lipotoxicity during obesity and its relevance to the development of type 2 diabetes. Project in progress. Image source: http://www.sxc.hu

Lipid Rafts in Brain relate to Genetic Obesity Lipid rafts (LRs) are membrane subdomains enriched in cholesterol, glycosphingolipids and sphingolipids containing saturated fatty acid. Signaling proteins become concentrated in these microdomains meanly by saturated fatty acid modification, thus facilitating formation of protein complexes and activation of specific signaling pathways. High intake of saturated fatty acids promotes inflammation and insulin resistance, in part by disrupting insulin signaling pathway. Here we investigate whether lipid-induced toxicity in obesity correlates with altered composition of insulin signalling proteins in LRs in brain. We have identified TANK-binding kinase 1 (TBK1) as a candidate to be upregulated during obesity. Our data support the hypothesis that hyperlipidemia associated with genetic obesity alters targeting of insulin signaling proteins membrane domains.

Camacho-Morales A, Delint-Ramirez I, Vidal-Puig A, Segoviano-RamĂrez JC. Genetic obesity correlates with disruption of insulin signaling proteins accumulation into lipid rafts in brain. In preparation. Image by Alberto Camacho-Morales

Mitochondrial disfunction and Obesity-Diabetes Mitochondria associated membranes (MAMs) include a subdomain leading to the regulation of mitochondrial function. Lipid accumulation during obesity and diabetes promotes mitochondrial dysfunction and activation of Endoplasmatic Reticulum Stress (ERE) in muscle, hepatocytes, pancreatic beta cells and cardiomyocytes. In this project we investigate whether obesity leads to mitochondrial dysfunction and ERE activation in hypothalamus by MAMs function. Our results might generate data to propose to the function of the MAMs as an important modulator of ERE and mitochondrial function, as triggers of pathogenic mechanism related to metabolic syndrome. Camacho-Morales A, et al, In preparation. 2013. Related publications: Camacho-Morales A, Rodriguez-Cuenca S, Blount M, Prieur X, Barbarroja N, Fuller M, Hardingham GE, Vidal-Puig A. Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response. Exp Neurol. 2012; 237(2):396-406. Puddifoot C, Martel MA, Soriano FX, Camacho A, Vidal-Puig A, Wyllie DJ, Hardingham GE. PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity. J Neurosci. 2012; 32(20):6995-7000. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho-Morales A, Barbarroja N, O’Rahilly S, Sethi JK, Dopazo J, Orešič M, Ricote M, Vidal-Puig A. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarisation in obese mice. Diabetes. 2011; 60(3):797-809. Image by Alberto Camacho-Morales

Motor function recovery after stroke Stroke is the first cause of disability and the third cause of death in Mexico. One type of disability results from damage to the motor system and consequently the patients can loose the complete use of the upper and/or lower limbs right after the stroke. Following the insult, the motor system starts to recover function of the affected limb by means of network reorganization and macroscopic plasticity. However, it is not yet clear by which means does the motor network reorganizes, to which extent does it recovers motor function nor the reason for the variability of the recovery in different patients. Our project aims to determine motor recovery after acute stroke following rehabilitation, and to study genetic, serological and neuroimaging biomarkers of motor function recovery to better understand it in our population.

Deplanque D, Lavallee PC, Labreuche J, Gongora-Rivera F, Jaramillo A, Brenner D, Abboud H, Klein IF, Touboul PJ, Vicaut E, Amarenco P; Lacunar-BICHAT Investigators. Cerebral and extracerebral vasoreactivity in symptomatic lacunar stroke patients: a case-control study. Int J Stroke. 2013; 8(6):413-21. Gongora-Rivera F., Navar-Vizcarra S., Villarreal-Velazquez H.J., GarzaVillarreal EA. â&#x20AC;&#x153;Superoxide dismutase polymorphism and its association to functional prognosis in strokeâ&#x20AC;?. In preparation. Image by Eduardo A. Garza-Villarreal

Nocturnal epilepsy and sleep disorders in children Several studies agree on the diagnostic difficulty between the types of nocturnal epilepsy and the different sleep disorders in children. Sleep is a state of the organism that is regular, cyclical and easily reversed, characterized by a type of disconnection from the external stimuli. Nocturnal epilepsy is a disorder with diverse causes that is characterized by seizures occurring while sleeping. Sleep and epilepsy are both bound by the same conditions of excitation and inhibition of the neurons, for which it is necessary to differentiate normal and abnormal phenomena in sleep from those that could be seizures, manifesting during sleep. The aim of this project is to describe and study the genetic and electroencephalographic endophenotype nocturnal epilepsy and sleep disorders in children. This project is a collaboration between the Department of Neurology of the Faculty of Medicine and University Hospital, the Neuroscience Unit and the Psychology of Health Unit of the CIDICS.

Duran-de la Re A, Garza-Villarreal EA, Chavez-Luevanos B, TellezLopez A, Abrego-Ambia AV, Gongora-Rivera F, Juarez-Garcia DM, Gutierrez-Barron MA, Villarreal-Velazquez HJ. Nocturnal epilepsy and sleep disorders in children. Project in progress. Image source: http://www.sxc.hu

Immunomodulators Our laboratoy is configured to the ongoing evaluation of new or already known molecules that can fulfill functions of immune response modifiers in medical therapeutics. The focus of research of this laboratory is, among others, anthelmintic drugs, and pesticides that have shown putative immunomodulatory properties such as levamisole, albendazole, ivermectin and diethylcarbamazine. The methodology used for evaluation processes of these and other drugs, is the measurement of respiratory burst, cytokine expression, production of antibodies assessment and evaluation animal models, among others. The service of our laboratory is supported by teachers / researchers of undergraduate and postgraduate medical school, and a chemist specializing in basic research and highly trained in the use of the methodologies used in the evaluation of the immune system.

Head of Immunomodulators Unit Carlos E. Medina-De la Garza carlos.medina@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1730

Spark the Immune System Immunomodulators are substances intended to enhance or decrease the actions of the immune system and thus achieve a desired effect upon a inflammatory, infectious or neoplasic process. Diethylcarbmazine (DEC) is an anthelmintic piperazine derivative drug, which has immune stimulating properties, including increased platelet and granulocyte adhesion to parasite. DEC has been proposed as candidate for evaluation as immunomodulatory drug with therapeutic potential. We analysed these properties in the BALB/c mice model and evaluate the effect of DEC on antibody, cellular citokine response and respiratory burst in. Our results shown higher dose treatment with DEC enhance significantly the respiratory burst of both polymorphonuclear leucocytes and monocytes. And enhances the IL and IL response. This result suggest a stimulating, dose-dependent immunomodulatory effect of DEC, which thus remain a strong candidate for ongoing assessment as an immunological modifier.

Medina-De la Garza CE., Guerrero-Ramirez G., García-Hernández M., Castro-Corona M.A., Torres-López E. Brattig N.W., Salinas-Carmona M.C. Immunomodulatory activity of diethylcarbamazine on humoral, cellular cytokine response and respiratory burst in BALB/C mice. Immunopharmacology and Immunotoxicology, 2012; 34(3):477-483 Figure: Model of Diethylcarbamazine (DEC) by Professors Luis Alejandro Pérez-López and Rosalba Ramírez-Durón, Analytical Chemistry Department, School of Medicine, UANL.

3D - Immunomodulation Tissues and cells undergo enviromental conditions that influence on their shape, intercellular comunications and functions. The mimetization of a target tissue and the development of its enviroment are important issues to consider in an in-vitro model culture. The three dimensional (3D) cell culture model biomimics the morphologic and functional characteristics of in-vivo parental tissues, and this work requires multidisciplinary strategies. The development of an inflamed in-vitro-intestinal tissue culture model based on human tissues may present a promising alternative to complement existing experimental systems to screen and study novel therapeutics. As a part of the training of one of us (MGH) and with support of Drs. Klaus Erttmann and Norbert Brattig in the Molecular Medicine Laboratory at Bernard Nocht Institute (BNI) there is a collaborative work, aimed to establish an in-vitro-intestinal tissue culture model that reflects the pathophysiological changes of inflamed intestinal tissue which can be used to evaluate the modulatory capacities of proteins, especially various Stongyloides-derived galectins. This will help determine potential use as immunomodulators against chronic inflammatory diseases and autoimmunity.

The need for immunomodulatory molecules to human clinical uses requires the determination and characterization of their biologic activities in a 3D tissue culture model and therefore to contribute to the knowledge of its possible future therapeutic potential.

Erttmann K., GarcĂa-HernĂĄndez M., Hansmann J., Liebau E., Brattig N.. Role of intestinal helminthes in the gut microbiome: Secreted proteins from Strongyloides may influence host immune status. First results were presented at the Cell Symposia: Microbiome and Host Health, on May 12-14, 2013 in Lisbon, Portugal.

Health Education Nursing Unit The goal of our work is the design, implementation and evaluation of forms of communication which use the the Internet, social networks, online platforms, text messaging and blogs with the purpose of providing health education. The target audience are health care providers of public and private organizations that provide health education and academic institutions interested in the research of the use of Technologies of Information and Communication for health promotion. Virtual environments may connect users and health care providers of organizations or communities to provide information or services that promote health to individuals and groups, enable greater collaboration with users and health providers to create networks and to promote the development of new content and services that promote health.

Head of Nursing Unit Raquel A. Benavides-Torres raquel.benavidest@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1764

Sexual Resilience in Adolescents Sexual Resilience in adolescents promotes safe sex through family, social and individual protective factors and counteracts sexual risk factors and risk associated with adolescence. Resilience is a mechanism that reduces the impact of risk because the teen is in a constant state of vulnerability and protective factors enable appropriate decision making about sexual risk situations. Thus, a teenager has protective factors that help to develop resilient capabilities, that favor having healthy behaviors. Resilience allows the adolescent to plan their future away from sexual risk situations. Sexual risk is exacerbated by the psychological changes (invulnerability) and defensive coping mechanisms (evasive, fatalistic and emotive) common at this stage of development. In this sense, resilience-based prevention and social competence must be addressed in the development of intervention programs, both elements are aimed at strengthening protective factors owned by the individual and reduce the risk factors, a program named “CONECTATE” was developed to promote sexual responsibility among young people; it is structured in eight sessions with interactive activities and three repositories of information, all of which can be delivered on a Website. The design of the website and learning platform represents an innovative means for health education and interactive learning sessions at low cost.

Castillo-Arcos L., Benavides-Torres RA. Modelo de Resiliencia Sexual en el Adolescente: Teoría de Rango Medio. Aquichan. 2012; 12(2): 169-182. Castillo-Arcos L, Benavides-Torres RA, López-Rosales F. Intervención por Internet para Reducir Conductas Sexuales de Riesgo para VIH/ SIDA: Una Propuesta Innovadora. Desarrollo Científico de Enfermería. 2012; 20(8): 266-270.

Sexually Transmitted Infections in Housewives: A Gender Perspective Data around the world show that housewives are more vulnerable to get HIV / AIDS than other population groups. Gender awareness in this populations is characterized by being submissive in their sexual encounters. In Mexico, the culture of machismo and the perspective of living in a in a sexist and patriarchal society put women at higher risk. Housewives report inconsistent use of condoms during sex, lack of knowledge about HIV prevention and low perception of risk. Housewives believe that their partner are monogamous and they do not protect themselves using a condom. Therefore it is very important to work with women to empower them and also there is the need to know the factors that predicts their behavior. According to this, we strive to promote sexual health though intervention programs to develop gender awareness to reduce the vulnerability of housewives to get STI-HIV/AIDS in the following years, so that the AIDS pandemic can be brought under control.

Onofre-Rodríguez DJ, Benavides-Torres RA. Imaginarios sobre las Infecciones de Transmisión Sexual en Mujeres. Estudio Comparativo. Aportaciones Actuales de la Psicología Social. AMEPSO. 2012; I: 581. Saenz-Soto NE, Benavides-Torres, RA. STD prevention in heterosexual couples and Community-Based Participatory Research. Leadership Forum. Sigma Theta Tau International Indianapolis, Indiana.

Talking about Sex in the Family HIV/AIDS, sexually transmitted infections and teenage pregnancies are common in marginalized urban communities. The family is the system that has a protective impact on adolescent sexual behavior, where communication between parents to children about sex is essential to change attitudes and behaviors. Educational interventions as “¡Cuídate!” (“Take care of yourself!”) are needed to increase knowledge, strategies and skills to provide parents to effective communicate with their children Parents acknowledged that is difficult to communicate with their children about sexuality and peer pressure, and they are afraid to provide freedom and sexual information that is not adequate. Parents from low socioeconomic status commonly have feelings of guilt or shame to talk about sexual issues with their children because they think that their past behavior about sex has not been appropriate to provide counseling to them. In relation to the educational intervention and the general objective, the intervention “¡Cuídate!” increased teenparent communication on sex in marginalized urban communities within the metropolitan area of Monterrey, N. L., we found a significant positive effect on parental sexual communication in the two tracking after the educational intervention. In conclusion, the intervention “¡Cuídate!” was effective for the population studied, increasing parental knowledge and skills to enhance communication in families.

Marquez-Vega, MA, Benavides-Torres RA, Gallegos-Cabriales EC, Repetto P, Montoya-Flores BI. Programa de educación sexual para padres de comunidades urbanomarginadas: prueba piloto. 2011. http://www. congresobiomedico.org.mx/memorias2011/htm/1830/1040.htm Olvera-Blanco MA, Benavides-Torres RA, Cruz-Castruita RM, LópezRosales F, Onofre-Rodríguez DJ, Márquez-Vega MA. Modelo de Acompañamiento para la implementación efectiva de programas para prevenir el VIH/SIDA. Evidentia. 2013; 10 (41). Marquez-Vega MA. Intervención sobre comunicación sexual para padres en comunidades urbano-marginadas. Doctoral Thesis. UANL. México. 2012

Integral Dentistry Unit The aims of this unit is to determine the etiology of oral cavity diseases and implement the use of biotechnological tools for their treatment. Also seeks to identify biomolecules as new antimicrobial options, mimicking the natural behavior of oral bacteria. Infrastructure assets to support research in this Unit includes: anaerobic-chamber, microscope for fluorescence (Axio Inverter Z.1, Carl-Zeiss), a Stereomicroscope (Carl-Zeiss), Incubators, Analgesi贸metro, Real-time Real-time and End-Point Thermal Cycler, Gel Doc XR, Cameras electrophoresis, Analysis of proteins by ionic charge (Protean IEF Cell), Densitometer GS-800 (hydrophobicity of several compounds), Spectrophotometer, fume hood, ELISA plate reader for 96 wells, ice machine, deep freezer at -80 掳 C.

Head of Integral Dentistry Unit Myriam A. De la Garza-Ramos miriam.garzarm@uanl.edu.mx +52(81)1340-4370 / 8329-4000 ext. 1781

Bio-Materials Currently, researchers from the School of Mechanical and Electrical Engineering (FIME) and CIDICS have developed a new biocompatible alloy with higher mechanical, tribological and biological applications for for surgical treatment of bone fractures (osteosynthesis), specifically for total joint replacement where premature wear has been one of the primary causes of failure. These multidisciplinary studies, including participation of our Unit (Dr. Myriam De La Garza-Ramos) have revealed that such novel cobalt based alloy with additions of boron is biocompatible in cell cultures. This innovation generated at UANL gives new biomaterials alternatives for thousands of patients. Alvarez-Vera M, Ortega-Saenz JA, Hernandez-Rodriguez MAL. A study of the wear performance in a hip simulator of a metal–metal Co–Cr alloy with different boron additions. Wear. 2013. 301: 175–181

Antimicrobial efficacy We tested neutral super-oxidized electrolyzed gel and chlorhexidine digluconate for antimicrobial efficacy and cytotoxicity in fibroblasts. Cultures were prepared with Streptococcus intermedius, Porphyromonas gingivalis and a mixture of both. Chlorhexidine digluconate showed no bacterial growth and a greater cell cytotoxicity (22.08% cell viability), compared with super-oxidized gel (97.16%). Super-oxidized gel inhibited bacterial growth around the mini-implant. Chlorhexidine digluconate acted as a bactericide. Chlorhexidine digluconate had a greater cytotoxic effect when compared with neutral super-oxidized electrolyzed gel.

Torres-Capetillo E, Carrillo-Fuentevilla R, De la Garza-Ramos MA, Mercado-Hernández R, Torre-Martínez H, Segoviano-Ramírez JC. Antimicrobial efficacy of neutral super-oxidized electrolyzed gel versus chlorhexidine digluconate 0.12% in biofilm formation on orthodontic mini-implants: An in vitro study. Journal of Pharmacognosy and Phytotherapy. 2013 , 5(4): 64-71.

Quorum-Sensing Density can regulate various functions in bacteria. Among them several cell functions associated with secondary metabolism, biofilm formation and virulence gene expression. This phenomenon was discovered in the marine bacteria Vibrio fischeri and Vibrio harveyi which produce autoinducers, and when their concentration reaches a threshold level in environment, they bind to a response regulator protein and induce expression of luciferase gene cluster. Today, we can recognize two kind of quorum-sensing systems in V. harveyi, one of them utilizes an acylhomoserine lactone as the signal and other uses a luxS-encoded signal. Porphyromonas gingivalis is an oral bacterium that has been implicated in periodontitis, and it possesses a luxS gene homologue that might be implicated not only in a quorum-sensing system but also in stress gene regulation. In this study, we report the regulation of gene expression in P. gingivalis as response to different cell concentration of Streptococcus intermedius, another natural oral habitant. Both bacteria were incubated at the following ratios: 1:1, 1:10 and 10:1 of P. gingivalis: S. intermedius. The genetic expression of the locus PG0520, PG0538 and PG1280 was evaluated with qPCR.

Aguirre-Arzola VE, Pereyra-Alferez B, Sanchez-Najera RI, Galan- Wong LJ, De La Garza-Ramos MA, Alcazar-Piza単a AG. Evidence of cross gene regulation of some virulence factors of Porphyromonas gingivalis by Streptococcus intermedius. African Journal of Biotechnology. 2013. 12(28), 4498-4502.

Antimicrobial of CatDex activity The investigation includes compounds with potential antiseptic efficacy e.g. natural extracts, bacteriocins and CatDex, a polyguanidine construct. CatDex has previously been demonstrated to have high anti tumor cell efficacy demonstrated in tumor cell cultures from prostate, breast, bladder and renal cell cancers. In the present investigation CatDex was examined in the CIDICS as an oral antiseptic and tested against two common oral bacteria, Porphyromonas gingivalis and Streptococcus mutants. CatdDex showed significant efficacy as oral antiseptic demonstrated in the most common oral bacteria and without toxicity to the oral mucous membranes. Additional studies on CatDex antimicrobial properties are in progress. This piece of research is made possible through partnership with Dr. Marcela Marquez Holmberg and Dr. Andres Holmberg from Department of Oncology and Pathology Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.

Meurling L., Marquez M., Nolson S. and Holmberg A.R. Polymer conjugated guanidine is a potentially useful anti-tumor agent. International Journal of Oncology. 2009; 35: 281-285. Van Cleemput M., Cattoor K, De Bosscher K, Haegeman G, De Keukeleire D, Heyerick A. Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds. Journal of Natural Products. 2009; 72: 1220-1230. Baca-Castañón ML. Antimicrobial effect Lactobacillus reuteri on bacteria involved in dental caries and periodontal disease. Bachelor Thesis. UANL. 2012 Escamilla-García E., Alcázar-Pizaña A.G., De La Garza-Ramos M.A., Medina-De La Garza C.E., Márquez M. Antimicrobial of CatDex activity against Porphyromonas gingivalis-W83 and Streptococcus mutansUA130. Journal of Dental Research (Special Issue). 2013; 3-4. ISSN 1544-0591 Figure shows the confocal microscopy image 63X, S. mutants incubated 4 hrs with 100 uM Catdex-FITC (green color). Dapi (blue color) as dye for the cell nucleus. (Juan Carlos Segoviano-Ramírez and Dr Erandi Escamilla-García).

Isolation of Human Pulp CD44 Mesenchymal Stem Cell Current perspectives in tissue engeneering include isolation of mesenchymal stem cells present in adult tissues; at present there are great expectations for therapeutic use, the stem cells have self-renewal, proliferation and differentiation, is for this reason they are an excellent alternative for the treatment of lesions in dental tissues and periodontal structures.

De la Garza-Ramos MA, Del ﾃ］gel-Mosqueda C, Isolation of human dental pulp stem cells CD271 and CD44 using MACSﾂｮ Technology. AADR Annual Meeting, Tampa, Florida. 2012 (http://iadr.confex.com/ iadr/htsearch.cgi).

Bio-Modelling Unit The unit is intended to be a complement to the research process by providing technical quality, research experience, ethics and proper management of the different experimental models as required. All this with adherence to international standards of quality (FELASA, AAALAC), in handling experimental animals of experimental animals, as well as personnel trained in the care of experimental models in each of the work areas. Our aim is to facilitate the procedures and above all to improve the quality in each experiment to be performed. This unit is designed to operate in safety BSL levels 1 and 2 as the team which will be counted as an individual controlled air system and high safety standards air to generate appropriate containment and biosafety projects, flexibility species to work including fish (zebra fish), small mammals (mini pig) and others. This unit is known for its features as an Animal Facility.

Head of Bio-Modelling Unit Mario A. Guzmán-García Coordinator of Bio-Modelling Unit Víctor Daniel L. Garzón-Cortés victor.garzoncr@uanl.edu.mx +52(81)1340-4370 / 8329-4000 ext. 1830

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Biologic Models in Orthodontics Dogs are one of the most widely animal models used in dentistry, but their use is becoming increasingly constrained by international standards in animal care. Because of this, researchers around the world are looking for new options to replace them. One model that offers alternatives for handling, immune response and anatomical knowledge, among others, is mini-pig or Vietnamese pig (Sus scrofa ussuricus) offers alternatives for easy handling, immune response and anatomical similarity among others. In Dentistry, mini dental implants have been used in various ways: to replace missing teeth, as anchoring means for traction on orthodontic treatment, and to align and retract anterior teeth without back support, etc.

In vivo results of the experiment show that chlorhexidine is bactericidal because it reduces tissue inflammation and promotes a slow epithelialization therein.

However, use of mini dental-implants causes swelling around implantation site, due to presence of oral cavity bacteria. Chlorhexidine is used to prevent oral infections; its main action is as inhibitor of bacterial growth. We tested chlorhexidine to prevent inflammation, and showed a much stronger effect of this antiseptic on mini implants on Vietnamese pigs using clinical parameter and histopathological confirmation. The objective of this project was to test the effectiveness of chlorhexidine in a living model (Vietnamese pigs) and histopathological confirmation from biopsies of tissue surrounding the mini implant.

Garzón-Cortés, V. D. L., Flores-Castillo, P. A., Carrillo, R., Guzmán, M. A., De la Garza, M. A. & Martínez, R. Reduction of inflammation of the surrounding tissue of a miniimplant in Sus scrofa ussuricus using chlorhexidine digluconate gel. Journal of the American Association for Laboratory Animal Science. 2012; 51(5): 707. Figure. Procedure of mini-implants placement in Vietnamise pig.

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Use of Biologic Models in Genitourinary Infections The effect of reproductive tract infections on fertility and neonatal infections has been debated for decades. No definitive conclusions have been reached so far, due to several factors, such as the difficulty in isolating the responsible pathogens, the absence of symptoms indicating a genitourinary disease and subclinical inflammatory processes. Chlamydia trachomatis is a very frequent sexually transmitted pathogen which infects 90 million people annually. On the other hand, Ureaplasma urealyticum cause chronic lung disorders and is an important cause of morbidity and mortality in newborns. These two organisms have a high affinity for epithelial surfaces of the female urogenital tract. The pathogenic mechanisms of genital tract infection by Chlamydia trachomatis murine variety (Chlamydia muridarum) represent an in vivo system similar in many respects to acute infections of the genital tract in women. This similarity is useful for studying the mechanism of this infection.

The objective of this study was to implement a murine model to study this chronic endometrial infection and to identify the histopathological alterations caused by them. In vivo results confirm that infection with Chlamydia trachomatis and Ureaplasma urealyticum cause significant cell damage to the endometrial tissue.

Álvarez-Cuevas S, Ramos-González B, Garzón-Cortés VDL., GuzmánGarcía M, Áncer-Rodríguez J, Noguera-Salvá R, Gallegos-Ávila MG. Modelo murino para el estudio de la co-infección endometrial por Chlamydia trachomatis y Ureaplasma urealyticum. XXVII Congreso Nacional de Investigación en Medicina. “Translational Medicine from Bench to Bedside”. Monterrey, Nuevo León, México. 2011 Figure. Histologic endometrial murine analyses as follows, columns: hematoxylin, reticulin fiber and Masson’s trichrome staining, and rows: control, carrier media, Chlamydia trachomatis and Ureaplasma urealyticum (40 X).

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Use of Biologic Models in Assessing Osseointegration in Dentistry The search for the ideal “anchor” has been a long sought goal in orthodontics. Micro-implants are small intraosseous screws, specially designed for use in orthodontics and are used to reach maximum anchorage. Titanium is the great biocompatibility material for micro-implants. It is preferred to use a smooth surface rather than a rough (microblasted) of prosthetic implants because osseointegration (direct structural and functional connection between bone and the implant surface without interference from soft tissue) is not sought. Currently the grade V titanium is used because it inhibits osseointegration and the same level of resistance is maintained. The purpose of this investigation is to determine the degree of osseointegration of microrough and smooth surface titanium implants in animal models.

Flores-C P, Carrillo-F. R, De La Garza-R M, Guzman-G.MA, Vazquez-A. A, Herrera-R. JdeJ, Garzon-C. D. “Inflammation gum tissue around a mini-implant in Sus scrofa ussuricus using chlorhexydine digluconate gel”. EUA. Journal of the American association for laboratory animal science. 2012. 51. This project suceed in close collaboration with the Dentistry Unit. Figure. Computed tomography witih and without mini-implants in lagomorph model.

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Bioimaging The Bioimaging Unit at CIDICS works as a Core Facility, supporting researchers doing their works in the life sciences area. Our goal is to support researchers doing technical training, innovation and development of technology in the area of morphologic sciences and microscopy. The Unit offers to interested researchers the installed capacity to run their own research protocols. We offer training curses about microscopic techniques, management of tissue samples and their preparation for microscopic analysis in bright field, fluorescence, confocal laser, scanning electronic and transmission electronic microscopy, as well as training for acquisition and analysis of images. Also Unit offers its facilities to researchers, research groups and / or companies interested in the development of instruments, equipment and other devices that may be useful to the medical community or constitute advances to microscopy development and applications. http://cidics.uanl.mx/bioimagen/

Coordinator of Bioimaging Unit Juan Carlos Segoviano-RamĂrez juan.segovianor@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1766

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Molecular Biology, Genomics and Sequencing Unit Specialized in molecular biology and genomics, our laboratory provides a wide range of genetic services and products to the health, pharmaceutical, food, and biotechnology industries. Topic areas: Infectious Diseases: Identification and Diagnosis of known pathogens in biological or industrial applications. Metagenomics: searching for and identifying genomes of microorganisms (viruses, bacteria and fungi) in a variety of samples (clinical or industrial) for diagnostic or quality control. Oncogenomics/Genetics: massive or selective analysis of biomarkers in cancer and genetic diseases. Pharmacogenomics: identification and analysis of genetic polymorphisms in metabolizing enzymes of drugs (phase I and II), transporters and receptors associated with drug response. Sequencing: Research and DNA sequencing services Personalized Medicine: Diagnostic applications available for health professionals Animal Genetics: Research and diagnostic services for breeders and researchers Food quality: We develops and applies qualitative and quantitative DNA technologies to the genetic traceability of agro-alimentary products in unprocessed and processed products.

Head of Molecular Biology, Genomics and Sequencing Unit Roc铆o Ortiz-L贸pez rocio.ortizl@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1750

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Circulating microRNAs as Biomarkers for the onset of HPV infection MicroRNAs are 19–24 nucleotide noncoding RNAs that can play important post-transcriptional regulatory roles in living cells affecting a variety of physiological cellular pathways such as proliferation, differentiation and apoptosis. The discovery of stable microRNAs in bodily fluids indicated their potential as non-invasive biomarkers. Cervical cancer is the third most common cancer among women in the world, is strongly associated with human papillomavirus (HPV) infection. The ability to detect precursors to cervical cancer relies on women presenting for repeat cervix testing at regular intervals, which is an uncomfortable test for any woman. Early cancer detection and prognosis strategies are based on the identification and validation of biomarkers which are highly indicative of disease progression from normal or precancerous tissue to early invasive cancers. The aim of our work is to investigate the presence of circulating microRNAs and their association with different stages of cervical cancer or precancerous lesions of the cervix associated with HPV infection, in order to provide a non invasive alternative to uncomfortable monitoring/screening practices. Using miRNA microarray analysis, 19 circulating miRNAs were identified as differentially expressed among four groups of study: cervix cancers, HPV positive dysplasias, HPV positive with normal cytology and HPV negative with

normal cytology. In the figure we observe two clusters apparently sub-regulated in dysplasia samples; but not in the other three groups. These 19 miRNAs are being analyzed in a larger group of women to validate its potential use as biomarkers. Their accessibility in peripheral blood and stability given the fact that miRNAs circulate confined within exosomes, make researchers foster hope in their role as emerging biomarkers of cervical cancer and other disorders. Martinez-Fierro ML, Leach RJ, Gomez-Guerra LS, Garza-Guajardo R, Johnson-Pais T, Beuten J, Morales-Rodriguez IB, Hernandez-Ordoñez MA, Calderon-Cardenas G, Ortiz-Lopez R, Rivas-Estilla AM, AncerRodriguez J, Rojas-Martinez A. Identification of viral infections in the prostate and evaluation of their association with cancer. BMC Cancer. 2010;10:326. Prado JC, Calleja-Macias IE, Bernard HU, Kalantari M, Macay SA, Allan B, Williamson AL, Chung LP, Collins RJ, Zuna RE, Dunn ST, Ortiz-Lopez R, Barrera-Saldaña HA, Cubie HA, Cuschieri K, von Knebel-Doeberitz M, Sanchez GI, Bosch FX, Villa LL. Worldwide genomic diversity of the human papillomaviruses-53, 56, and 66, a group of high-risk HPVs unrelated to HPV-16 and HPV-18. Virology. 2005 Sep 15;340(1):95104. Downregulation of nineteen plasma circulating miRNAs in patients with cervix dysplasia associated to HPV infection. In process Figure: Heat map for 41 miRNAs pre-selected from a massive miRNA microarray analysis. “A” and “B” indicate the 19 miRNAs apparently sub-regulated in dysplasia group.

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Genomic tools for prognosis assessment in Acute Myeloid Leukemia Acute myeloid leukemia (AML) is a clonal disorder caused by malignant transformation of cells derived from bone marrow. AML is a heterogeneous group of disorders with genetic abnormalities and variable response to treatment. Certain structural chromosomal changes (eg. presence of translocations 8; 21 and 15, 17) and numerical changes (presence of monosomy 5 and 7) have been associated with an unfavorable prognosis respectively. Similarly, mutations in FLT3, NPM1 and C/EBPα have demonstrated great importance for prognostic. More recently, variants in the gene copy number (CNV) is been implicated as important pathogenic factors for the development of cancer. However in the absence of common markers of poor prognosis in patients with aggressive clinical phenotype, it requires the identification of surrogate markers that explain the clinical phenotype. Currently, approaches more sensitive as array comparative genomic hybridization (aCGH) is used to identify genetic changes associated with cancer pathogenesis. Eventually, some of these changes could include genes associated with favorable or unfavorable prognosis for patients and we could to include aCGH as a prognostic method in our AML patients. Our goal is to implement and evaluate the use of genomic microarrays as a support tool for determining prognosis in patients with AML.

We obtained the frequency of occurrence of mutations in 30 screened AML samples; deleted regions were the mainly alteration found in the analyzed samples in regions including cancer-related genes or chromosomal aberrations previously associated to hematopoietic malignancies and AML, the chromosomes that showed more abnormalities were 5 and 7.

Gutierrez-Aguirre CH, Garcia-Rodriguez F, Ortiz-Galvez VM, CantuRodriguez OG, Salazar-Riojas R, Martinez-Gonzalez OL, Gonzalez-Llano O, Jaime-Pérez JC, Ortiz-Lopez R, Flores-Jimenez JA, Alatorre-Ricardo J, Mancias-Guerra C, Gomez-Almaguer D. Lower than expected cytogenetic and molecular response to imatinib in Mexican patients with chronic myelogenous leukemia. Hematology. 2013;18(4):224-9. Ruiz-Argüelles GJ, Garcés-Eisele J, Ortiz-López R, Rivas-Llamas R, Gómez-Almaguer D, Ruiz-Delgado GJ. Molecular characterization of chronic myeloproliferative neoplasias in México. Hematology. 2009;14(5):261-5.

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Prognosis of acute lymphoblastic leukemia type B in Mexican patients Acute lymphoblastic leukemia (ALL) remains the leading cause of disease-related death in young people and new therapeutic approaches directed against rational therapeutic targets are urgently required to improve treatment outcomes. This is particularly true for ALL in older children, adolescents, and adults, in whom treatment outcomes are markedly inferior to those of young children. A major goal of current leukemia research is to use comprehensive genomic analysis of the leukemic cell. Few studies have reported and validated gene expression prognostic biomarkers of ALL type B (B-ALL). This biomarkers analysis in childhood ALL could be remarkably informative to identified a number of new alterations in the expression or regulation of genes that play important roles in the establishment of the leukemic clone and determine risk of relapse. The aim of this study is to analyze the expression profile of 45 genes associated to signaling pathways involved in ALL and a group of 600 miRNAs, to evaluate their association with the prognosis of the disease. Samples of peripheral blood mononuclear cells at three different times (diagnosis, four and eight weeks after starting treatment) from 73 B-ALL patients have been studied. Gene expression profiles of 45 mRNAs and 667 highly characterized human miRNAs, have been analyzed by real-time quantitative polymerase chain reaction.

From the 45 analyzed genes, normalized dCt values of 23 genes showed differences between non leukemia controls and B-ALL. The association between FLT3 deregulation and relapse/ death was a constant in the three studied times. From the 667 analyzed. 77 miRNAs were differentially expressed. We have found that at least 17 cellular pathways are involved in ALL pathogenesis and that FLT3 retained independent prognostic significance value for unfavorable B-ALL outcome, reflected as increased risks of relapse/death in the study population and AKT2 and RUNX1 could be used as a therapeutic targets for ALL. These findings highlight biomarkers that could be associated with clinical and biological prognostic factors in B-ALL. Gutierrez-Aguirre CH, Garcia-Rodriguez F, Ortiz-Galvez VM, Cantu-Rodriguez OG, Salazar-Riojas R, Martinez-Gonzalez OL, Gonzalez-Llano O, Jaime-Pérez JC, Ortiz-Lopez R, Flores-Jimenez JA, Alatorre-Ricardo J, Mancias-Guerra C, Gomez-Almaguer D. Lower than expected cytogenetic and molecular response to imatinib in Mexican patients with chronic myelogenous leukemia. Hematology. 2013 Jul;18(4):224-9. Ruiz-Argüelles GJ, Garcés-Eisele J, Ortiz-López R, Rivas-Llamas R, Gómez-Almaguer D, Ruiz-Delgado GJ. “Molecular characterization of chronic myeloproliferative neoplasias in México”. Hematology. 2009;14(5):261-5. Figure: Volcano Charts of miRNAs differentially expressed in patients with B-ALL versus non leukemia controls. Cutoff values of p = 0.05 in the y-axis (-log 10 0.05 = 1.3) and an exchange rate of 2 in the x-axis (log2 = 1). Green dots represent over-expressed miRNAs and the red dots to sub-expressed.

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Pharmacogenomics in patients with breast cancer Genetic variation influences the response of an individual to drug treatments. Understanding this variation has the potential to make therapy safer and more effective by determining selection and dosing of drugs for an individual patient. In the context of cancer, tumours may have specific disease-defining mutations, but a patient’s germline genetic variation will also affect drug response (both efficacy and toxicity), and here we focus on how to study this variation. Based on sequencing technologies and statistical genetics analysis methods, our laboratory has been focused in the discovery of variants associated with drug response in different types of cancer. In the case of breast cancer, this is a public health problem that affects women worldwide. Although there are therapies directed against the malignant cells, due to a diagnosis at advanced stages of the disease, it is increasingly common the administration of systemic chemotherapy, along with a serie of adverse effects. So it is necessary to search for biomarkers for diagnosis and / or prognosis to help us understand the mechanisms of response to chemotherapy treatment, and try to offer the option of a personalized treatment that improves individual response and help us to prevent side effects.

Our goal is to evaluate the outcome of treatment by chemotherapy in patients clinically diagnosed with breast cancer, evaluating the pharmacogenetics and pharmacokinetics of doxorrubicine and adriamicine treatment.

Canseco-Ávila LM, Jerjes-Sánchez C, Ortiz-López R, Rojas-Martínez A. Determination of molecular genetic markers in acute coronary syndromes and their relationship to cardiovascular adverse events. Arch Cardiol Mex. 2013 Jan-Mar;83(1):8-17. Dorado P, Machín E, de Andrés F, Naranjo MEG, Peñas-Lledó EM , Llerena A, Moya GE, Ferreiro V, Tarazona-Santos E, Fiedler J, Herrera L, Rojas-Ponce R, Sarmiento AP, Borbón A, Barrantes R, Jiménez-Arce G, Céspedes C, Rodeiro I, Álvarez M, Pérez B, Calzadilla LR, Delgado R, Remirez D, Terán E, Heras N, Beltrán LJ, Hernández F, Ortiz-López R, Rojas-Martínez A, Garza-Ocañas L, Pérez-Páramo YX, López-López M, Ortega-Vázquez A, Alonso-Vilatela E, Monroy-Jaramillo N, Corona Vázquez T, Yescas-Gómez P, Ochoa-Morales A, Sosa-Macías MG, Galaviz-Hernández C, Lares-Aseff I, Lazalde B, Ramirez-Roa R, Grazina M, Cobaleda J, Estévez-Carrizo FE, González-Vacarezza N. Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes. Drug Metabol Drug Interact. 2012;27(4):217-33. Vázquez-Martínez OT, Martínez-Rodríguez HG, Velásquez-Arenas L, Baños-González D, Ortíz-López R, Padilla-Rivas G, Welsh O, OcampoCandiani J. Treatment of vitiligo with a melanocyte-keratinocyte cell suspension versus dermabrasion only: a pilot study with a 12-month follow up. J Drugs Dermatol. 2011 Sep;10(9):1032-6. Soriano-Hernández AD, Galvan-Salazar HR, Montes-Galindo DA, Rodriguez-Hernandez A, Martinez-Martinez R, Guzman-Esquivel J, Valdez-Velazquez LL, Baltazar-Rodriguez LM, Espinoza-Gómez F, Rojas-Martinez A, Ortiz-Lopez R, Gonzalez-Alvarez R, Delgado-Enciso I. Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: a preclinical evaluation. Int Urol Nephrol. 2012 Apr;44(2):471-7.

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Microarray technology platforms (Affymetrix and NimbleGen) Our unit, through the genotyping and expression laboratory, focuses to study chromosomal rearrangements related to congenital diseases, mainly those that affect the CNS and/ or cause multiple malformations such as facial dysmorphia or developmental malformations. The high resolution of the used microarray platforms in our lab, let us to elucidate the causative genetic defects of the different human disorders and to understand the functional relevance of pathogenic mutations and the cell protein signaling networks the respective proteins are embedded in. Besides studying congenital defects, platforms allow us to study the genetic component of different acquired diseases (e.g. cancer) or perform an analysis of DNA natural variants related to changes in the drugs metabolism (pharmacogenomics). In the cancer field, we have studied genomic changes to level of gene copy number, gene expression and methylation. On the other hand, DNA copy number variants, which account for the greatest portion of genetic variability in humans and their phenotypic consequences, are currently rather unknown and those can range from benign to neutral and disease causing. For instance, the same genetic change appears to have no biological relevance at all in one individual, while it causes severe health problems in another one.

Thus, our group has the goal to investigate the variable phenotypic consequences of DNA copy number variants against the background of the modifying influence exerted by the individual genetic background. Altogether, our research lines focus to ascertaining genotype-phenotype associations of human diseases.

Neira VA, Romero-Espinoza P, Rojas-Martínez A, Ortiz-López R, Córdova-Fletes C, Plaja A, Barros-Núñez P. De novo MECP2 disomy in a Mexican male carrying a supernumerary marker chromosome and no typical Lubs syndrome features. Gene. 2013 Jul 25;524(2):381-5. Córdova-Fletes C, Domínguez MG, Vázquez-Cárdenas A, Figuera LE, Neira VA, Rojas-Martínez A, Ortiz-López R. A de novo sSMC(22) Characterized by high-resolution arrays in a girl with cat-eye síndrome without coloboma. Molecular Syndromology 3:131-135. 2012. Neira VA, Córdova-Fletes C, Grondin Y, Ramirez-Velazco A, Figuera LE, Ortíz-López R, Barbaro M.Complex 9p rearrangement in an XY patient with ambiguous genitalia and features of both 9p duplication and deletion. Am J Med Genet A. 2012 Jun;158A(6):1498-502.

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Genomic platforms applied to Biotechnology industries Next-generation sequencing (NGS) technologies have demonstrated the capacity to sequence DNA at unprecedented speed, thereby enabling previously unimaginable scientific achievements and novel medical and biological applications. NGS are revolutionizing biology and can be applied to address critical issues in Biotechnology. These technologies can produce draft sequences of genomes with a significant reduction to the cost and timeframe of traditional technologies. In addition, NGS technologies can be used to assess gene structure and expression, and importantly, to identify heritable genome variation underlying important agronomic or bio-industry traits. Our laboratory uses different platforms [454 Flex and Jr (Roche), Ion-Torrent (Life Technology) and MiSeq (Illumina)] to provide service to other researchers or Biotechnological enterprises. We had actually participated in the sequencing of several organisms with biotechnological application in order to know their genome structure and be able to easily make improvements at the biological process directly applied to improve production and enhance safety.

Vera-Cabrera L., Ortíz-López R., Elizondo-González R., Pérez-Maya A., Ocampo-Candiani J.; “Complete genome sequence of Nocardia Brasiliensis HUJEG-1”. J. Bacteriol. 2012. 194(10): 2761. Vera-Cabrera L., Ortíz-López R., Elizondo-González R., Ocampo-Candiani J.; “Complete genome sequence analysis of Nocardia Brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis”. J. PLoS One. 2013 Junio 3;8 (6):e65425. Sánchez-García A, Ríos-Ibarra CP, Rincón-Sánchez AR, Ortiz-López R, Garza-Juárez A, Morlett-Chávez J, Martínez-Rodríguez H, Rivas-Estilla AM. Use of proteomic analysis tools to identify HCV-proteins downregulated by acetylsalicylic acid. Annals of Hepatology. 2013; 12(5) 1-5.

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Bioinformatics - Comprehensive Data Analysis The bioinformatics laboratory, as part of the Molecular Biology and Genomics unit is capable of analyzing data from NGS platforms including Ion Torrent, Illumina, 454 Titanium and 454 Jr. Data from Whole Genome, Transcriptome and Targeted Amplicon sequencing projects is processed and assembled using the most fitting software available (e.g. Newbler, IDBA, Mira, BWA, Trinity, MUMmer, Tablet, Ugene, etc). As part of collaboration we have sequenced, assembled and published the genome of Nocardia brasiliensis. There are onging genomics analysis of brewing yeasts, shrimp transcriptome, HIV quasispecies identification, detection of CFTR novel mutations, genome sequencing of Staphylococcus sp. and the targeted sequencing of a breast cancer amplicon pannel of genes to identify variants among other projects. The laboratory counts with several computing systems including a 2 X Hexa-core, 47 GB RAM and 11 TB server.

Grondin Y., Ortiz-López R.; Bioinformática en la era de las ciencias ‘ómicas’. Ciencia Conocimiento Tecnología. 2011. Número 116, p.p.35-38. Cerda-Flores RM, Rivera-Prieto RA, Pereyra-Alférez B, Calderón-Garcidueñas AL, Barrera-Saldaña HA, Gallardo-Blanco HL, Ortiz-López R, Flores-Peña Y, Cárdenas-Villarreal VM, Rivas F, Figueroa A, Kshatriya G. Genetic structure of Mexican Mestizos with type 2 diabetes mellitus based on three STR loci. Gene. 2013 Aug 1;525(1):41-6.

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Knowledge-Management Unit The Knowledge-Management Unit (UAC) is a service unit of CIDICS whose task is to offer researchers the best sources of information, specialized publications and updated scientific databases. This unit possess also an exclusive array of 689 books, 560 titles and 613 printed volumes all orientated to the specialized ongoing work of the CIDICS working units. With leading edge technology in video conferences, electronic classroom (computer lab), we have wide spaces for multiple uses and are the core of sources of information at CIDICS. Besides, the Unit cooperates in proper investigation of: knowledge management, scientific evidence for the public politics, think tanks (laboratory of ideas) intellectual property and communication and health. Furthermore, the unit works in different projects together with the General Directorate of Libraries (DGB) of UANL and The Pan-American Organization of the Health (PAHO) with their project United States-Mexico Virtual Library of Health.

Head of Knowledge-Management Unit Juan Manuel Saldivar-Blanco juan.saldivar@dgb.uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1739

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UANL Data-Bases The Data Bases of Universidad Aut贸noma de Nuevo Leon (UANL) grant access to 52 electronic resources, 1,382 digital books and 91,000 periodic publications that can be accessed by means of the Digital Library at our web site. These data bases have an important digital array that is free of charge for students and professors and offers a great variety of contents segmented in 6 thematic areas: Life Sciences, Health Sciences, Engineering and Exact Sciences, Economy and Administration, Social Sciences and Education, Arts and Humanities. The General Directorate of Libraries (DGB) of UANL is on charge to manage this material that includes tools of great help to research like: the newspaper library EL Porvenir, The bibliographical manager End Note, the citation browser from Web of Science as well as the Journal Citation Reports that measures the impact factor of journals. It also has support of CONACyT through program (CONRyCIT) and is one of the strongest information resources in our University.

It can be accessed at: http://www.dgb.uanl.mx/?mod=bdigital

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Think Tanks as a Health Tool The relevance to create proper public policies based on scientific knowledge has turned into development and strengthening of organizations named Think Tanks (TT). From the beginning of XX century, these public and private organizations have fostered research oriented to have great impact and influence upon stakeholders and decision makers. At the Knowledge-management Unit of CIDICS and in close cooperation with the Public Health Unit, we have adopted this approach to the concept of Think Tanks oriented to health sciences, in order to put facts and knowledge at the reach of decision makers and stakeholders, mainly at government level, thus deepening and expanding their area of influence und allowing them to reach the best decisions regarding health issues, that will have an impact in the community, and set the basis to renew old, or develop brand new public policies.

Saldivar-Blanco, JM. [â&#x20AC;&#x153;Think-Tankâ&#x20AC;? design in Health Sciences ] M.A. Thesis, UANL 2012

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Bioethics Unit The Bioethics Unit together with COBICIS (Ethics Committee of CIDICS) advises and helps on the development of research projects involving Bioethical issues. A Bioethics Unit is an essential part of every research center, for its in charge to provide a fair and ethical assessment of every protocol and clinical trial and those involving biological models as well. COBICIS follows the guidelines of our Unit international network with UNESCO on Bioethics and is registered on the Mexican network of Bioethics. CIDICS is thus registered in U. S. Department of Health and Human Services (HHS), Office for Human Research Protections (OHRP), FEDERAL WIDE ASSURANCE (FWA), and IRB Organizations (IORGs), also with Mexican registration at COFEPRIS, CONBIOETICA and all due regulatory organisms.

Head of Bioethics Unit Eloy Cรกrdenas-Estrada eloy.cardenases@uanl.edu.mx +52(81)1340-4370 / 8329-4000 ext. 1743

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Advance Directive in the state of Nuevo León It is ascribed to human rights activist Luis Kutner, the proposal of a living will, the advance directive. This document contains the will of a person regarding his/her medical management in case of terminal illness. This advance directive defines the limits of his/her treatment in order not to fall into the case of suicide or assisted/caused death. The advanced directive also seeks to avoid therapeutic obstinacy through the excessive use of medical technology and seek therefore a dignified death giving every autonomy right to the patient. While some federal states in Mexico already have the advance directive in their legislation, Nuevo Leon state is still missing this law. Our goal is to provide the ethic and medical concepts and background to the lawyers and legislators, and work together with our Law School to include this regulation for advance directive in our state laws.

García-Montelongo F, Hernández-Morales JH, Gutiérrez-Martinez AK, Leal-Isla-Sánchez G, Cantú-Lazo R, Cárdenas-Estrada E. Estudio comparativo de Legislaciones de Voluntad Anticipada en México. VII Coloquio de Humanidades. México. 2013 (http://www.researchgate. net/publication/236659216_POSTER-01-CIDICS-UBe-Voluntas)

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The legacy of Fritz Jahr The German theologian and educator Paul Max Fritz Jahr (Halle an der Saar, 1895-1953) is credited with the coining of the term “Bioethics” in 1927, as he published is assay “Bioethics: an overview of ethical relationship of man with animals and plants” (“Bio-Ethik: Eine Umschau über die ethischen Beziehungen des Menschen zu Tier und Pflanze”) The concepts and teachings of Jahr were relegated in his own country during the dreadful times of the nationalsocialistic terror-state, but resurfaced and were used by scientists to find an humanistic view of Science. The bioethical imperative of respect from human life to natural resources, animals, plants and environment is also evident from the writings of this pastor. We have to be aware, in the light of new discoveries and knowledge, new behaviors and values, to preserve ethics in science and medicine. Our group seeks to expand and deepen the knowledge of Jahr’s legacy to ensure a preeminent role of ethical values in our scientific society.

Original source: Bio-Ethik. Eine Umschau über die ethischen Beziehungen des Menschen zu Tier und Pflanze. Kosmos. Handweiser für Naturfreunde 1927, 24(1): 2-4 Figure: http://www.google.es/imgres?sa=X&hl=es&biw=1280&bih= 880&tbm=isch&tbnid=ls83B1HIBc_0zM:&imgrefurl=Fritz-Jahr

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Software for Informed Consent and Sample-Size Calculation In order to ease the process of evaluating the contents of the informed consent presented in each research protocol, we have developed a easy to use software. In close collaboration with the Center for Mathematical Research from CONACyT (CIMAT) which supplied the computer system tools and know-how for the purpose, we performed the analysis of technical terms used and provide common words easy to be understood by the undersigning person. In further collaboration with CIMAT, we have developed a software to make an easier calculation of sample size for clinical research. This software has been distributed free of charge to organizations and researchers who attend fairs and events where CIDICS is present. We are developing other bioethics topics for computers, tablets and mobile-phones.

https://sites.google.com/site/cobicis/ http://www.cimat.mx/es/Monterrey

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Vaccinology Unit and Clinical Studies This Unit is designed to support Phase III and Phase IV clinical trials on efficacy and effectivity of vaccines in association with pharmaceutical industry. These studies require personnel properly trained in research to suit the needs of sponsors and protect participating individuals, as well as follow up and analysis of data. Besides three ongoing studies on vaccines, CIDICS seeks further to expand the number and reach of such studies, needed for the right evaluation and future use of much needed vaccines, such as dengue fever and pentavalent streptococcus pneumoniae. Additionally, CIDICS will start this year clinical studies for end stage testing of compounds for their registration in Mexico and some other novel compounds, including natural origin substances. For this purpose CIDICS has the facilities and rooms designed for clinical and bioavailability studies. This former facilities will be in full availability for the pharmaceutical industry soon.

Head of Vaccinology Unit and Clinical Studies Eloy Cรกrdenas-Estrada eloy.cardenases@uanl.edu.mx +52(81)1340-4370 / 8329-4000 ext. 1743

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Tissue Engineering Unit This new unit was created to develop research combining stem-cell technology and new materials to create tissue and organs for biomedical purposes. We aim to apply tissue engineering focused to produce, as first goal, human skin from fat tissue stem-cells. This Unit works with support of the Department of Clinical Pathology from our University Hospital (Head Dr. Fernando PérezChávez) and Pathology (Head Dr. Oralia Barbosa-Quintana). Currently, basic studies on recovery and culture of stem-cells are performed, with the goal of reaching the stage of tissue printing.

Head of Tissue Engineering Unit Fernando Pérez-Chávez fernando.perezch@uanl.mx +52(81)1340-4370 / 8329-4000

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CIMAT Monterrey The Centro de Investigación en Matemáticas (Mathematical Research Center), CIMAT, was founded in 1980 in Guanajuato, Mexico. It is a public research center within the CONACYT Public Centers System, dedicated to the generation, transmission and application of mathematical, statistical and computer science knowledge. CIMAT has as its main objectives: • To generate scientific knowledge through research in the disciplines that constitute the Center’s field of work. • To educate human resources with excellence in these disciplines. • To strengthen the competencies in related areas within the public, private and social sectors in Mexico, through liaison projects. As a part of the Center’s expansion program, CIMAT’s Monterrey Unit came into being in 2009, and it is located at the CIDICS since 2012. Among the joint CIDICS-CIMAT Monterrey lines of research are: • Epidemiological models for infectious diseases.

• Models for the analysis of medical images, static and functional. • Models for the analysis of genomic prevalences and risks in addictions. The CIDICS-CIMAT Monterrey collaboration is consolidating with publications, and grows steadily in a natural manner thanks to the reunion in the same institution of research efforts in health sciences and in mathematics, statistics and scientific computing, allowing the academic teams to interact in an efficient and continuous manner.

Head of CIMAT Monterrey (CONACYT) Graciela González-Farías farias@cimat.mx +52(81)1340-4370 / 8329-4000 ext. 1778

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Academic, Educative & Outreach Projects

Human Variome Project (HVP) – México Many diagnostic tests now exist for many genetic disorders. However, not enough information on genetic variations and their effects is making its way out of labs and clinics and being shared, within countries and internationally. Too often there is no available information, or even worse, incorrect information, because there is no system in place to collect all of this vital knowledge and make it accessible to the world. For the HVP, its core purpose is to alleviate needless suffering for millions of the world’s people by collecting, organizing and sharing data on genetic variation. If diagnosis is much slower than otherwise possible, people will not only suffer from the physical effects of disease, but they and their families will also suffer from psychological, emotional and economic effects. The HVP Consortium is motivated by the knowledge that by working together, we will be able to significantly reduce such needless suffering. In a meeting of the Mexican Association of Human Genetics (AMGH), representatives of the Centro Médico Nacional Siglo XXI, Centro Médico Nacional de Occidente, IMSS, Centro Médico Nacional 20 de Noviembre, ISSSTE, Hospital General de México, INMEGEN, Hospital Infantil de México, and the Universidad

Autónoma de Nuevo León (UANL), handed the responsibility to the CIDICS at the UANL to organize the National Node: Bioinformatics; Clinical Genetics; Ethical, Legal and Social Implications; Communication; and Administration. The school of Biology supports also CIDICS on this project. The HVP-México will represent the multidisciplinary and cooperative nature of the effort between Mexican geneticists, patients, institutions and the society.

Human Variome Project - México Responsible: Augusto Rojas-Martínez Bioinformatics: José Arcadio Valdés-Franco Website: hvpmexico.uanl.mx Patrinos GP, Smith TD, Howard H, Al-Mulla F, Chouchane L, Hadjisavvas A, Hamed SA, Li XT, Marafie M, Ramesar RS, Ramos FJ, de Ravel T, El-Ruby MO, Shrestha TR, Sobrido MJ, Tadmouri G, WitschBaumgartner M, Zilfalil BA, Auerbach AD, Carpenter K, Cutting GR, Dung VC, Grody W, Hasler J, Jorde L, Kaput J, Macek M, Matsubara Y, Padilla C, Robinson H, Rojas-Martinez A, Taylor GR, Vihinen M, Weber T, Burn J, Qi M, Cotton RG, Rimoin D; International Confederation of Countries Advisory Council. Human Variome Project country nodes: documenting genetic information within a country. Human Mutation. 2012; 33(11):1513-9.

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Businesses and R&D Research and Development is a very important part in any enterprise. It typically involves generation of new ideas to expand business and achieve better economic gains. There are two acknowledged lines of work: one to develop new commercial or industry products whereas the other scope is to generate new knowledge per se. Universities have traditionally focused on the latter while leaving the former somewhat on the side. We strive to fill this gap by applying the results of our research to establish strategic alliances with government, industry and private organizations while taking full advantage of products, processes, services, technologies, or ideas generated by the many ongoing research projects. It is our purpose to protect the intellectual property through appropriate legal procedures like copyright, trademarks, patents, industrial design rights, etc. On the other hand, CIDICS also provides space and infrastructure for incubation of technology-based business and research services.

Interested in businesses scheme with CIDICS? Contact: Dr. Carlos E. Medina-De la Garza Director carlos.medina@uanl.mx

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Science in Motion at CIDICS - UANL Under the motto “Scientists educating Scientists”, the CIDICS divulgation program “Science in Motion”, aims to arouse interest among high school students into research in Medicine, Biology, and Life Science. The goal of the program is to spread science knowledge in students between 15-18 years old, in order to get involved, take interest in research and choose the best option as a career, in order to better educate future quality scientists in Mexico. Contribution to society: • Social responsibility must take into account the higher education institutions, with the partnership approach to the world of science. • Contribute to the development of critical mass of young scientists in our country. • Physical presence at our institution, given the opportunity to see first-hand, the sciencerelated issues. • Meet the scientists who are expected to be a “role model” to guide the imagination, attitudes, and talents of students.

José Gerardo Velasco-Castañón gerardo.velascoc@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1761 Daniela Azpilcueta-Salinas daniela.azpilcuetas@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1723

Among the activities carried out in the program include holding conferences with the presence of a group of students in CIDICS, and “The Cinema and Science”, the projection of films for dissemination and promotion of interest in science, directly on schools facilities. 153

National Week of Science and Technology (SNCyT) Every year a week is dedicated to communication in Science and Technology. This annual event encompasses a wide range of activities to provide a converging stage for all interested in promoting Science and scientific thinking as well as science teaching in order to foster the development of human resources. Sponsored by Consejo Nacional de Ciencia y Tecnologia (CONACyT), it is carried out in every state in Mexico focusing in children teenagers and young adults. It is a celebration well suited to provide a rapprochement between scientists, popularizers, researchers, entrepreneurs, and technologists in a scenario of cordiality and deference to younger generations who are encouraged to follow a career as scientists. The SNCyT is a forum through which thousands of Mexican children and teenagers learn about the many possibilities open in the fields of productive activity, scientific research and teaching. Its mission is to project science as a cornerstone for economic development, cultural and social development of our country. Shared this purpose educational institutions, scientific associations, state departments, companies, research centers, science museums and state governments. Concrete is creative and proactive events of scientists, teachers, communicators and business cycles by means of conferences, workshops, exhibitions, demonstrations, tours, contests and science fairs, among

others. The SNCyT is part of the communication activities of Science and Technology institutionally held throughout the country. The purpose: to awaken the interest of these disciplines among the children and youth, under the motto, â&#x20AC;&#x153;To grow you must knowâ&#x20AC;?.

http://www.conacyt.gob.mx/comunicacion/Paginas/SemanaNacCyT.aspx

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Ibero-american Network for Communication and Health The Latin-American Network of Communication and Health (REDICOMSA) is integrated by researchers, academic and professional personnel of the area of communication and health of a number of universities from México and abroad, dedicated to promote and strengthen research and training of human resources, and provide specialized services to elaborate development projects in the ever growing field of communication and health. The CIDICS hosts REDICOMSA headquarters since april 2012. Summoning a number distinguished researchers and specialists (both national and international) in order to share knowledge and experiences to support schools and institutions to develop academic programs, as well as collaboration to establish graduate studies programs in the field of health and communication. Among the participants on REDICOMSA can be found: the Ministry of Health of the State of Nuevo León, The Universidad Complutense de Madrid, Spain, the Department of the Province of Buenos Aires (Argentina), the Foundation of Education for the Health (Spain), the Universidad Autónoma de Madrid (Spain) and our Universidad Autónoma de Nuevo León.

http://www.comunicacion.uanl.mx/ http://cidics.uanl.mx/

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Divulgation of Science and Biotechnology at CIDICS The goal of the Scientific and Technological Dissemination and Divulgation Area of CIDICS is to provide scientific and technological knowledge, in an attractive and simple format, to the general public and particularly professors and students of UANL. Our goal is focused in encouraging researchers to disseminate their work in print media, but specially online in the web, among other projects we have developed a scientific and technological divulgation journal named: Conocimiento UANL (KNOWLEDGE UANL), which spreads concepts, hypothesis, thesis, laws, theories, facts, research and work, on the subjects of science and technology, covering the university, local, national and international scopes. This publication arises as part of the festivities for the 80th Anniversary of the UANL and its first issue on May 2013, features the subject: RESEARCH IN UANL, which presents, by its own researchers, investigation activities by the various faculties of our institution. Conocimiento UANL can be access online at the website: revistaconocimiento.uanl.mx Another project in support and coordination with the Direction of Publications of the UANL is a science and technology book collection, named: “La Ciencia a tu Alcance”, whose main objective is to make accessible, the scientific and technological knowledge, to the general public.

We have published the first seven works in various branches of human knowledge, which were developed with simple language and numerous images, to make them more attractive. The titles and authors are: “Vaccines and Human Health” by Dr. Mario Cesar Salinas-Carmona, “Human Machines. Between Knowing and Doing” by Dr. Anastacia Rivas-Olivo, “Corn, Wheat and Rice. The Grains Feeding the World” by Felix Ramos-Gamiño; “An Adventure To Outer Space” by Dr. José Ruben Morones-Ibarra, “Nature. That Exotic Beauty, Low Priced” by Dr. Eder Zavala-López, “Science in Everyday Life “by Milton Maciel Mata-Guerrero, and “Brief History of Corruption” by Mr. Juan Roberto Zavala. These books, plus still see, can be viewed on the portal cienciaatualcance. uanl.mx We have also created a scientific a technology blog, named: “Reporte Ciencia” in order to contribute with knowledge to the communication society. Our contributors can be students, teachers and doctors, elaborating brief news and articles, accepting social responsibility to disseminate these ideas into popular knowledge. The blog can be consulted at: reporteciencia.uanl.mx Luis Eugenio Todd-Pérez luis.toddp@uanl.mx +52(81)1340-4370 / 8329-4000 ext. 1754

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Information and Data Sharing Technology â&#x20AC;&#x153;The things you share are things that make you look good, things which you are happy to tie into your identity.â&#x20AC;?* Strategic institutional communication involves projecting work in progress at CIDICS so both health professionals and general public are able to access relevant information, so along this line we are developing an APP, that is an application software for mobile devices, since these are a very important tool to reach a large number of people, either individuals or groups in an ever growing number of social networks like the paradigm setting Facebook. Our first version is being tested for smartphones or tablets using the Android operating system, it is intended to be small, fast, and easyto-use developed to fully take advantage of a small touchscreen interface. Unlike desktop applications, our app is intended to be used onthe-go. An iPhone app will be developed son thereafter. We strive to provide a social network service as a mean to build social networks or social relations among people who, share interests, activities, backgrounds, or real-life connections within health sciences, patient care or public health to share ideas, data, pictures, comments, activities, events, and interests not only within our University but as a projection of social responsibility.

*Hilary Mason, chief data scientist, VentureBeat, 2012

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MEDICA - D端sseldorf Germany The internationalization process of UANL involves both academic and business opportunities. To foster this process, we at CIDICS seek also partnerships regarding businesses and offering of services within Mexico and abroad. Thus in November 2012, we decided to participate in MEDICA, the world fair for medical products and services in D端sseldorf, Germany. In this yearly venue, the world meets to offer the best of products and opportunities for those working in health and related fields. In a market growing annually around six percent, we seek to offer not only research services at CIDICS (sequencing, gene and cell therapy or chemical compound testing, among other), but also services and products of UANL aimed at global market. This is the first time a Mexican university participates in MEDICA and after the 2012 edition we will be representing UANL again in 2013 in the PROMEXICO stand. UANL is expected to be aware of the challenges and opportunities of an ever changing health market and to have a competitive edge, thus we have to take every opportunity to become an international player at our best of knowledge and skills.

http://www.medica.de/

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National & International Networking In the global society of today, partnerships and cooperation are required. The sustainable progress of CIDICS and our University requires from our scientists commitment, knowledge and skills to work in international and multidisciplinary environments. Many of our relations with Mexican and foreign universities and companies are result of personal acquaintance or even friendship among scientists or former colleagues. Whatever its origin, it is our goal to strengthen our commitment to those partners with whom we work in a productive, friendly and equitable fashion, and create and foster mutually fruitful relationships. In this regard, we do not only cooperate with scientific groups within UANL, but also with other local universities in Nuevo Leon State and its Health Ministry, and with Institutions in Mexico as Universidad Autónoma de México (UNAM), Instituto Politécnico Nacional (IPN), Universidad de Guadalajara (UdeG), Instituto Mexicano del Seguro Social (IMSS). We are aware that to become a solid international partner, means to be a good partner anywhere, starting locally, nationally and thus internationally. Examples of good working relationships are also ties to Karolinska Institutet, Sweden, University of Bonn and Bernhard Nocht Institut, Germany, University of Aarhus, Denmark, University of Toronto, Canada, University of California, Davis, University of Texas Health Science Center at San Antonio, National

Cancer Institute, USA, Oxford University, Sanger Institute, UK, Universidad Nacional de Colombia, Universidad del Valle, Colombia, Universidade Estadual de Campinas, Universidade Federal do Rio Grande do Sul, Brasil.

http://cidics.uanl.mx/

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Publications Publication is the proper culmination of scientific labor and it is the cornerstone of science. Here we present the collection of original work carried out by CIDICS professionals in our own facilities and in collaboration with colleagues at other institutions in the United States, Europe and South America, from 2010 to date.

2010 Bonilla C.A., Rubio M.S., Sifuentes A.M., Parra-Bracamonte G.M., Arellano V.W., Méndez M.R., Berruecos J.M., Ortiz R.; Association of CAPN1 316, CAPN1 4751 and TG5 markers with bovine meat quality traits in Mexico. Genet Mol Res. 2010. 14;9:2395-405. Flores-Ramírez R., Uribe-Longoria A., Rangel-Fuentes M.M., Gutiérrez-Fajardo P., Salazar-Riojas R., CervantesGarcía D., Treviño-Ortiz J.H., Benavides-Chereti G.J., Espinosa-Oliveros L.P., Limón-Rodríguez R.H., MonrealPuente R., Rojas-Martínez A.; Intracoronary Infusion of CD133+ Endothelial Progenitor Cells Improves Heart Function and Quality of Life in Patients with Chronic PostInfarct Heart Insufficiency. Cardiovasc Revasc Med. 2010. 11:72-78. Huerta-Pérez L., Cortés-Hernández D.E. Comité de Vigilancia Epidemiológica Línea Basal de seguridad vial en Nuevo León. Boletín del Consejo Estatal de Prevención de Accidentes Nuevo León. Volumen 1, 2010.

Arteaga S., González V., Kurniawan S. & Benavides R. Mobile games and design requirements to increase teenagers’ physical activity in Mexico. Journal of Pervasive and Mobile Computing. 2011. Borrego Soto G., y cols. Terapia génica y celular: nuevas alternativas para la regeneración del tejido óseo. Ciencia Conocimiento Tecnología. 2011. 116, 21-24.

Guzmán F., López K., Alonso M. & Benavides R.; Jóvenes de pandillas en Monterrey: El significado del consumo de drogas. En: Problemas Relevantes de Salud Pública en la Región Noreste de México. COLEF. 2011.

Cárdenas-Estrada E., Medina-De la Garza C.E.; Bioética en Investigación. Ciencia Conocimiento Tecnología. 2011. 116, 50-53.

Guzmán-García M.A., Garzón-Cortés V.L.; La experimentación en animales de laboratorio. Ciencia Conocimiento Tecnología. 2011. 116. 58-59.

Castro-Corona M.A. Inmunología Odontológica. Medicina Universitaria. 2011: 13:112-113

Kuehn A., Chircop A., Downe-Wamboldt B., ShepparedLeMoine D., Wittstock L., Herbert R., Benavides-Torres R., Murnaghan D. & Critchely M.; Evaluation of the Impact of a North American Nursing Exchange Program on Student Cultural Awereness. International Journal of Nursing Education Scholarship. 2011. 8(1).

Cervantes-Garcia D., Rojas-Martinez A., Camerini D. An XMRV Derived Retroviral Vector as a Tool for Gene Transfer. Virol J. 2011. 8:284. Cortés- Hernandez D.E.; Una Epidemia Silenciosa. Medicina Universitaria. 2011:3-4

Martinez-Fierro M.L., Leach R.J., Gomez-Guerra L.S., Garza-Guajardo R., Johnson-Pais T., Beuten J., Morales-Rodriguez I.B., Hernandez-Ordoñez M.A., Calderon-Cardenas G., Ortiz-Lopez R., Rivas-Estilla A.M., Ancer-Rodriguez J., Rojas-Martinez A.; Identification of viral infections in the prostate and evaluation of their association with cancer. BMC Cancer. 2010. 10:326.

Cortés-Hernández D.E., El Conocimiento en Salud Pública, puente entre la práctica y la política pública. Ciencia Conocimiento Tecnología. 2011; 116: 14-16.

Peralta R., Baudis M., Vazquez G., Juárez S., Ortiz R., Decanini H., Hernández D., Gallegos F., Valdivia A., Piña P., Salcedo M.; Increased expression of cellular retinol binding protein 1 in laryngeal squamous cell carcinoma. J Cancer Res Clin Oncol. 2010. 136:931-938.

Frausto V., Rico R., Martínez P. & Benavides R.; Normas Subjetivas para VIH/SIDA y las Actitudes Sexuales en Adolescentes. Enfermería Global. 2011; 10: 1-7.

Rios-Ibarra C., Blitvich B.J., Farfan-Ale J., Ramos-Jiménez J., Muro-Escobedo S., Martínez-Rodríguez H.R., OrtizLópez R., Torres-López E., Rivas-Estilla A.M.; Fatal human case of West Nile disease, Mexico, 2009. Emerg Infect Dis. 2010. 16:741-743. Velasco-Castañón J.G., México ante el mundo: la reciente pandemia de Influenza. Medicina Universitaria. 2010. 12:248-249.

2011 Acosta-Olivo C., Elizondo-Rodriguez J., Araujo-Lopez Y., Mendoza-Lemus O., Cardenas-Estrada E, Moreno-Gonzalez J.A.; Comparison of Botulinum Toxin a and Intralesional Steroids for the Treatment of Plantar Fasciitis: A Randomized, Double-Blinded Study. Foot & Ankle International. 2011 Álvarez-Aguirre A., Alonso-Castillo M., Benavides-Torres R., López K., Alonso B. & Guzmán F. La prevención de adicciones desde el análisis evolucionario de Rodgers. Ciencia Ergo Sum. 2011. 17.253-257.

Grondin Y., Ortiz-López R.; Bioinformática en la era de las ciencias ‘ómicas’. Ciencia Conocimiento Tecnología. 2011. Número 116, p.p.35-38.

De la Garza-Ramos M.A., Escamilla-García E.; Unidad de Odontología Integral y Especialidades. Ciencia Conocimiento Tecnología. 2011; 116: 48-49.

García-Hernández M., Medina-De la Garza C.E., CastroCorona M.A., La inmunomodulación en la terapéutica moderna. Ciencia Conocimiento Tecnología. 2011; 116: 28-30. Garza-Cortez R., Cárdenas-Cadena S.A., Gómez-Guerra L.S., Garza-Guajardo R., Ortíz-López R., Grondin Y., Leach R.J., Reveles X.T., Rojas-Martínez A.; Genomic rearrangement analysis in aggressive prostate cáncer. Rev. Mex Urol. 2011; 71:160-163 Garza-Veloz I., Castruita-De la Rosa C., Cortés-Flores R., Martínez-Gaytán V., Rivera-Muñoz J.E., García Mayorga E.A., Meza-Lamas E., Rojas-Martínez A., Ortiz-López R., Martínez-Fierro M.L.; No association between polymorphisms/haplotypes of the vascular endotelial growth factor gene and preeclampsia. BMC Pregnancy and Childbirth 2011, 11:35. González-Farías G.; Ciencias de la Salud y Matemáticas en Monterrey, Ciencia Conocimiento Tecnología 2011. 116: 45-47. Grondin Y., Ortiz-López R.; Análisis de la variabilidad genómica humana a muy alta resolución. Ciencia Conocimiento Tecnología. 2011. 116, 38-44.

Kuehn A.F., Chircop, A., Downe-Wamboldt, B., SheppardLeMoine, D., Wittstock L., Herbert R., Benavides-Torres, R.A., Murnaghan D., Critchley K., Evaluating of The Impact of a North American Nursing Exchange Program on Student Cultural Awareness. International Journal of Nursing Education Scholarship. 2011; 8:1-2 Luévano-González A., Guzmán A.Q., Ancer-Rodríguez J., Ortiz-López R., Rojas-Martinez A., González-Guerrero J.F., Flores-Gutiérrez J.P.; Analysis of DNA mismatch repair proteins expression and BRAF V600E Mutation in a subset of early-and late-onset colorectal carcinoma patients in Mexico. Arch Med Res. 2011;42 :457-62 Marino-Martinez I.A., Barboza-Quintana O., Rojas-Martínez A.; Cáncer cervical: interacción de la célula tumoral y su entorno inmunológico. Ciencia Conocimiento Tecnología. 2011. 116, 25-27. Medina-De la Garza CE; El Centro de Investigación y Desarrollo en Ciencias de la Salud, Una Realidad de Vanguardia. Ciencia Conocimiento Tecnología 2011.116: 6-8. Medina-De la Garza C.E., Koschwitz M.C.; Johann Peter Frank y la medicina social. Medicina Universitaria. 2011; 13: 163-168. Medina-De la Garza C.E.; La Oncología en la medicina Mexicana. Medicina Universitaria. 2011; 13: 114-115. Montes- Villarreal E.; La Bioseguridad. Revista Ciencia Conocimiento Tecnología. 2011; 116: 54-57. Palacios-Saucedo G.C., Rivera-Morales L.G., VázquezGuillén J.M., Sánchez L.M., Ramírez T.J., Briones E., Ortiz-López R., Vázquez C.A., Rodríguez-Padilla C.; Drug Resistance Mutations during Structured Interruptions of HAART in Two HIV-1-Infected Children. Curr HIV Res. 2011. 9:154-9.

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Torres-López E; Desarrollo y Evaluación Vacunas: Su aplicación Biotecnológica. Ciencia Conocimiento Tecnología 2011.116: 31-34

Benavides R., y colaboradores. “Implicaciones de GREECA para el cuidado de Enfermería, la Docencia e Investigación en el Fenómeno de las Drogas”. 2012.

Saldívar-Blanco J.M.; Administración del conocimiento para las ciencias de la salud. Ciencia Conocimiento Tecnología. 2011. 116 17-20.

Benavides-Torres R.A., Wall K.M., Núñez Rocha G.M., Onofre Rodríguez D.J., Hopson L.; “Factors associated with lifetime HIV testing in Texas by race/ethnicity”. The Open AIDS/Journal. 2012. 232-238.

Saldívar-Blanco J.M.; Una guía actual para la escritura científica. Medicina Universitaria. 2011; 13: 50-68. Soriano-Hernández A.D., Galván-Salazar H.R., MontesGalindo D.A., Rodríguez-Hernández A., Martínez-Martínez R., Guzmán-Esquivel J., Valdez-Velázquez L.L., Baltazar-Rodríguez L.M., Espinoza-Gomez F., Rojas-Martínez A., Ortiz-López R., González-Álvarez R., Delgado-Enciso I.; Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: a preclinical evaluation. Int Urol Nephrol. 2011 Soriano-Hernández AD, Galvan-Salazar HR, MontesGalindo DA, Rodriguez-Hernandez A, Martinez-Martinez R, Guzman-Esquivel J, Valdez-Velazquez LL, BaltazarRodriguez LM, Espinoza-Gómez F, Rojas-Martinez A, Ortiz-Lopez R, Gonzalez-Alvarez R, Delgado-Enciso I.; Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: a preclinical evaluation. Int Urol Nephrol. 2011 Téllez-López A., Villegas-Ginea D.; La Psicología de la Salud. Ciencia Conocimiento Tecnología. 2011. 116: 60-62. Torres-Benavides R.A., Ph.D. Valdez-Montero C., MCE. González-González V.M., Ph.D. Onofre-Rodríguez D.J., MTS.; “Use of sexual material online and at-risk sexual behavior regarding HIV/AIDS among college students”. Journal of the American Medical Informatics AssociationBMJ. 2011. 1-5. Valle M., Benavides R., Álvarez A. & Peña J.; Conducta Sexual de Riesgo Para VIH/SIDA en Jóvenes Universitarios. Revista de Enfermería del Instituto Mexicano del Seguro Social. 2011. 19, 133-136. Vázquez-Martínez O.T., Martínez-Rodríguez H.G., Velázquez-Arena L., Baños-González D., Ortíz-López R., Padilla-Riva G., Welsh O., Ocampo-Candiani J. Treatment of Vitiligo With a Melanocyte-Keratinocyte cell suspension versus Dermabrasion only: A pilot study with A 12-Month Follow up. J Drugs Dermatol. 2011. 1; 10:1032-6. Velasco-Castañón J.G..; Lo que nos enseñó la pandemia de influenza. Ciencia Conocimiento Tecnología. 2011: 116: 9-13. 2012 Baca-Castañón ML. Antimicrobial effect Lactobacillus reuteri on bacteria involved in dental caries and periodontal disease. Bachelor Thesis. UANL. 2012

Camacho-Morales A, Rodriguez-Cuenca S, Blount M, Prieur X, Barbarroja N, Fuller M, Hardingham GE, VidalPuig A. Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response. Exp Neurol. 2012; 237(2):396-406. Cantú-Salinas C., Salinas-Santander M., Lagos-Ramirez A.M., Sanchez-Dominguez E., Rios-Ibarra C., Ortíz-López R., Welsh O., Ocampo-Candiani J.; “Tumor necrosis factor alpha promoter-308 G/A Polymorphism in Mexican patients with patchy alopecia areata”. International Journal Dermatology. 2012. 51, 571-575. Castillo-Arcos L., Benavides-Torres R.; “Modelo de Resiliencia Sexual en el Adolescente: Teoría De Rango Medio”. Aquichan. 2012. 12: 169-182. Castillo-Arcos L., Benavides-Torres R.A., López-Rosales, F.; “Intervención por internet para reducir conductas sexuales de riesgo para VIH/SIDA: una propuesta innovadora”. Desarrollo Científico de Enfermería. 2012. 20: 266-270. Castro-Govea Y., Cervantes-Cardasch V.H., Borrego-Soto G., Martínez-Rodríguez H.G., Espinoza-Juárez M., Romero-Díaz V., Marino-Martínez I.A., Robles-Zamora A., Álvarez-Lozano E., Padilla-Rivas G.R., Ortiz-López R., Lara-Arias J., Vazquez-Juárez J., Rojas-Martínez A. “Human bone morphogenetic protein 2-transduced mesenchymal stem cells improve bone regeneration in a model of mandible distraction surgery”. J Cranifac Surg. 2012; 23:392-396. Córdova-Fletes C., Domínguez M.G., Vázquez-Cárdenas A., Figuera L.E., Neira V.A., Rojas-Martínez A., OrtizLópez R. “A de novo sSMC (22) characterized by highresolution arrays in a girl with cat-eye syndrome without Colomba”.Mol. Syndromol. 2012. 3:131-135. De la Garza-Ramos MA, Del Ángel-Mosqueda C, Isolation of human dental pulp stem cells CD271 and CD44 using MACS® Technology. AADR Annual Meeting, Tampa, Florida. 2012 (http://iadr.confex.com/iadr/htsearch.cgi). De la Garza-Ramos MA, Alcazar-Pizaña A, Garza-Enriquez M, Caffesse R., Aguirre-Arzola V., Galán-Wong L.G., Pereyra-Alférez B.P.; “Streptococcus intermedius trgger quorum-sensing in porhyromonas gingivalis microorganisms in industry in environment from scientific and industrial research to consumer products”. 2012. 518-521.

De la Garza-Ramos MA, Luna-Ayala A, Garza-Enriques M, Martínez-Carreón D, Pereyra-Alferez B. Caffesse RG; “Streptococcus intermeduis can module the expression of some virulence factors in porphyromanas gingivalis”. Microbes in Applied Research: Current Advances and Challenges. 2012. Dohn A., Garza-Villarreal E.A., Heaton P., & Vuust P.; “Do musicians with perfect pitch have more autism traits than musicians without perfect pitch? An empirical study”. PLoS ONE. 2012. 7, e37961. Dohn A., Garza-Villarreal E.A., Ribe L.R., Wallentin M., Vuust P. “Musical activity tunes up absolute pitch ability”. Music Perception. 2012. Dorado P, Machín E, de Andrés F, Naranjo MEG, PeñasLledó EM , Llerena A, Moya GE, Ferreiro V, TarazonaSantos E, Fiedler J, Herrera L, Rojas-Ponce R, Sarmiento AP, Borbón A, Barrantes R, Jiménez-Arce G, Céspedes C, Rodeiro I, Álvarez M, Pérez B, Calzadilla LR, Delgado R, Remirez D, Terán E, Heras N, Beltrán LJ, Hernández F, Ortiz-López R, Rojas-Martínez A, Garza-Ocañas L, Pérez-Páramo YX, López-López M, Ortega-Vázquez A, Alonso-Vilatela E, Monroy-Jaramillo N, Corona Vázquez T, Yescas-Gómez P, Ochoa-Morales A, Sosa-Macías MG, Galaviz-Hernández C, Lares-Aseff I, Lazalde B, RamirezRoa R, Grazina M, Cobaleda J, Estévez-Carrizo FE, González-Vacarezza N. Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes. Drug Metabol Drug Interact. 2012;27(4):217-33. Flores-C P, Carrillo-F. R, De La Garza-R M, Guzman-G. MA, Vazquez-A. A, Herrera-R. JdeJ, Garzon-C. D. “Inflammation gum tissue around a mini-implant in Sus scrofa ussuricus using chlorhexydine digluconate gel”. EUA. Journal of the American association for laboratory animal science. 2012. 51. Flores M, Sunil TS, Picazzo-Palencia E, Cortes-Hernandez DE. A spatial analysis of the effects of international migration on infant mortality in Mexico. Social Development Issues. 2012; 32(2): 1-15. Gallegos J., Benavides R., Beretvas T. & Linan-Thompson L. “Psychosocial Interventions to Prevent Anxiety Disorders in School Settings from 1985–2007: A Meta-Analysis”. Educational Pshychology. 2012. Gallegos-Guajardo J., Ruvalcaba-Romo N.A. & BenavidesTorres R.A.; “Anxiety disorders in children: Prevention and early intervention”. Saarbrucken, Germany: LAP Lambert Academic Publishing. 2012. Gamez-Salas M.J., Lau-Rojo L., Verdugo-Barraza M. de L., De la Garza-Ramos M.A.; “Detection of microorganisms in patients with brackets MBT and Alexander”. Microbes in Applied Reserch: Current Advances and Challenges. 2012. 522-52.

Garza-Garza A.M., Llodra-Calvo J.C., Arce-Mendoza A.Y., De la Garza-Ramos M., Quiroga-García M.A.; “Detection of IgM and IgG antibodies against Mycobacterium tuberculosis in students”. Microbes in Applied Reserch: Current Advances and Challenges. 2012. 518-521. Garza-Villarreal EA, Brattico E, Leino S, Ostergaard L, Vuust P. “Distinct neural responses to chord violations: A multiple source analysis study”. Brain research. 2012; 1389: 103–114. Garza-Villarreal E.A., Brattico E., Vase L., Østergaard L., Vuust P.; “Superior analgesic effect of an active distraction versus pleasant unfamiliar sounds and music: the influence of emotion and cognitive style”. PLoS ONE. 2012. 7 (1), e29397. Garzón-Cortés, V. D. L., Flores-Castillo, P. A., Carrillo, R., Guzmán, M. A., De la Garza, M. A. & Martínez, R. Reduction of inflammation of the surrounding tissue of a miniimplant in Sus scrofa ussuricus using chlorhexidine digluconate gel. Journal of the American Association for Laboratory Animal Science. 2012; 51(5): 707. Geny Durán, Torres-Martínez H.H., De la Rosa E., Mercado-Hernandez, De la Garza-Ramos M.A.; “Spap gene of Streptococcus mutans in dental plaque and its relationship with early childhood caries”. Paedriat. Dent.; 2012.: 220240 Hernandez-Delgadillo R., Velazco-Arias D., Diaz D., Arevalo-Niño K., Garza-Enriquez M., De la Garza-Ramos M., Cabra-Romero C. “Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm”. International Journal. 2012. 7, 1-5. Laguna-Aguilar M, Alvarado-Moreno MS, Sánchez-Rodríguez OS, Ramírez-Jiménez R, Zárate-Nahón EA, SánchezCasas RM, Fernández-Salas I, Rebollar-Téllez EA. Field Evaluation of a Novel Trap Baited with Carbon Dioxide Produced by Yeast for the Collection of Female Aedes aegypti Mosquitoes in Mexico. Southwestern Entomologist. 2012; 37(4):495-504. Mangold E., Reutter H., León-Cachón R.B.R., Ludwig K.U., Herms S., Chacón-Camacho O., Ortiz-López R., Paredes-Zenteno M., Arizpe-Cantú A., Muñoz-Jiménez S.G., Nowak S., Kramer F.J., Wienker T.F., Nöthen M.M., Knapp M., Rojas-Martínez A.; “Evaluating SKI as candidate gene for nonsyndromic cleft lip with or without cleft palate”. Journal of Oral Sciences. Julio 2012. Marquez-Vega MA. Intervención sobre comunicación sexual para padres en comunidades urbano-marginadas. Doctoral Tesis. UANL. México. 2012 Marroquín-Rodríguez A.L., Martínez-Cervantes T.J., Morales-Cortés L., Garza-Villarreal E.A.; “Somatotipo de la mujer con Síndrome de ovario poliquístico”. FML. 2012. 16(4):4p.

Medina-De la Garza C., Guerrero-Ramírez G., GarcíaHernández M., Castro-Corona A., Torres-López E. Barattig N., Salinas-Carmona M.; “Immunomodulatory activity of diethycarbamazine on humoral celular cytokine reponse and respiratory burst in BALB/c mice”. Immunofarmacology and Immunotoxicology. 2012. 34: 477-483. Medina-De la Garza C.E.; “El papel de la academia en la Ciencia y Tecnología” Ingenierías. 2012. 54, XV. Moral-De La Rubia J., Segura-Herrera L.G., García-García E., Téllez-López A. “Estrés y Calidad de Vida Relacionada con la Salud en Padres de Niños con Leucemia Linfoblástica Aguda”. Revista Psicogente. 2012; 15:249-261. Neira V.A., Córdova-Fletes C., Grondin Y., Ramirez-Velazco A., Figuera L.E., Ortíz-López R., Barbaro M.; “Complex 9p Rearrangement in an XY Patient With Ambiguous Genitalia and Features of Both 9p Duplication and Deletion”. Am. J. Med. Genet. 2012. 158A, 149:502. Onofre-Rodríguez DJ, Benavides-Torres RA. Imaginarios sobre las Infecciones de Transmisión Sexual en Mujeres. Estudio Comparativo. Aportaciones Actuales de la Psicología Social. AMEPSO. 2012; I: 581. Ortíz-López R., Rojas-Martínez A., Garza-Ocañas L., Pérez-Páramo Y.X.; “Pharmacogenetics in Latin American populations: regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders”. Drug Metabol Drug Interact. 2012;27(1):57-60. Patrinos GP, Smith TD, Howard H, Al-Mulla F, Chouchane L, Hadjisavvas A, Hamed SA, Li XT, Marafie M, Ramesar RS, Ramos FJ, de Ravel T, El-Ruby MO, Shrestha TR, Sobrido MJ, Tadmouri G, Witsch-Baumgartner M, Zilfalil BA, Auerbach AD, Carpenter K, Cutting GR, Dung VC, Grody W, Hasler J, Jorde L, Kaput J, Macek M, Matsubara Y, Padilla C, Robinson H, Rojas-Martinez A, Taylor GR, Vihinen M, Weber T, Burn J, Qi M, Cotton RG, Rimoin D; International Confederation of Countries Advisory Council. Human Variome Project country nodes: documenting genetic information within a country. Human Mutation. 2012; 33(11):1513-9. Puddifoot C, Martel MA, Soriano FX, Camacho A, VidalPuig A, Wyllie DJ, Hardingham GE. PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity. J Neurosci. 2012; 32(20):6995-7000. Rivas-Estilla A.M., Bryan-Marrugo O.L., Trujillo-Murillo K., Pérez-Ibave D., Charles-Niño C., Pedroza-Roldan C., Ríos-Ibarra C., Ramírez-Valles E., Ortiz-López R., IslasCarbajal M.C., Nieto N., Rincón-Sánchez A.R.; “Cu/Zn superoxide dismutase (SOD1) induction is implicated in the antioxidative and antiviral activity of acetylsalicylic acid in HCV-expressing cells”. Am J Physiol Gastrointest Liver Physiol. 2012; (11):G1264-73.

Rodeiro I., Remírez-Figueredo D., y colaboradores. “Pharmacogenetics in Latin American populations: regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders”. Drug Metab Drug Interact. 2012; 27: 57-60. Salinas-Santander M, Díaz-García D, Rojas-Martínez A, Cantú-Salinas C, Sánchez-Domínguez C, Reyes-López M, Cerda-Flores RM, Ocampo-Candiani J, Ortiz-López R. Tumor necrosis factor-α 308G/A polymorphism is associated with active vitiligo vulgaris in a northeastern Mexican population. Experimental and Therapeutic Medicine. 2012; 3(5):893-897. Soriano-Hernández AD, Galvan-Salazar HR, MontesGalindo DA, Rodriguez-Hernandez A, Martinez-Martinez R, Guzman-Esquivel J, Valdez-Velazquez LL, BaltazarRodriguez LM, Espinoza-Gómez F, Rojas-Martinez A, Ortiz-Lopez R, Gonzalez-Alvarez R, Delgado-Enciso I. Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: a preclinical evaluation. Int Urol Nephrol. 2012 Apr;44(2):471-7. SPS3 Investigators, Benavente O.R., Hart R.G, McClure L.A., Szychowski J.M., Coffey C.S., Pearce L.A.; “Effects of clopidogrel added to aspirin in patients with recent lacunar stroke”. N Engl J Med. 2012 Aug. 30;367(9):817-25. Téllez-López A, Villegas-Guinea D, Juárez-García D, Segura-Herrera LG. Cuestionario Trastornos de Sueño Monterrey. Medicina Universitaria. 2012; 14(56): 150-156. Vera-Cabrera L., Ortíz-López R., Elizondo-González R., Pérez-Maya A., Ocampo-Candiani J.; “Complete genome sequence of Nocardia Brasiliensis HUJEG-1”. J. Bacteriol. 2012. 194(10): 2761. Vera-Cabrera L., Ortíz-López R., Elizondo-González R., Ocampo-Candiani J.; “Complete genome sequence analysis of Nocardia Brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis”. J. PLoS One. 2013 Junio 3;8 (6):e65425. Villarreal-Garcia L.E., Oranday-Cárdenas A., De la GarzaRamos M.A., Rivas-Morales C., Verde-Star M.J., GomezTreviño J.A.; “Activity methanolic extracts of Azadirachta Indica (A. Juss) on P. G.”. Microbes in Applied Reserch: Current Advances and Challenges. 2012. 2013 Aguirre-Arzola VE, Pereyra-Alferez B, Sanchez-Najera RI, Galan- Wong LJ, De La Garza-Ramos MA, Alcazar-Pizaña AG. Evidence of cross gene regulation of some virulence factors of Porphyromonas gingivalis by Streptococcus intermedius. African Journal of Biotechnology. 2013. 12(28), 4498-4502.

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Amarenco P., Lavallée P.C., Labreuche J., Ducrocq G., Juliard J.M., Feldman L., Cabrejo L., Meseguer E., Guidoux C., Adrai V., Ratani S., Kusmierek J., Lapergue B., Klein I.F., Gongora-Rivera F., Jaramillo A., Abboud H., Olivot J.M., Mazighi M., Touboul P.J., Steg P.G.; “Coronary artery disease and risk of major vascular events after cerebral infarction”. Stroke. 2013; 44(6):1505-11.

Garza-Veloz I, Romero-Díaz VJ, Martínez-Fierro ML, Marino-Martínez IA, González-Rodríguez M, MartínezRodríguez HG, Espinoza-Juárez MA, Bernal-Garza D, Ortiz-López R, Rojas-Martínez A. “Analyses of Chondrogenic Induction of Adipose Mesenchymal Stem Cells by Combined Co-stimulation Mediated by Adenoviral Gene Transfer”. Arthritis Research & Therapy. 2013; 15:R80

Camacho A., Huang J.K., Delint-Ramirez I., Yew-Tan C., Fuller M., Lelliott C.J., Vidal-Puig A., Franklin R.J.; “Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis”. Eur J Neurosci. 2013, E-pub. Canseco-Ávila LM, Jerjes-Sánchez C, Ortiz-López R, Rojas-Martínez A. Determination of molecular genetic markers in acute coronary syndromes and their relationship to cardiovascular adverse events. Arch Cardiol Mex. 2013; 83(1):8-17.

Gutierrez-Aguirre CH, Garcia-Rodriguez F, Ortiz-Galvez VM, Cantu-Rodriguez OG, Salazar-Riojas R, MartinezGonzalez OL, Gonzalez-Llano O, Jaime-Pérez JC, OrtizLopez R, Flores-Jimenez JA, Alatorre-Ricardo J., ManciasGuerra C, Gomez-Almaguer D; “Lower than expected cytogenetic and molecular response to imatinib in Mexican patients with chronic myelogenous leukemia”. Hematology. 2013; 18:224-229.

Cerda-Flores R.M., Rivera-Prieto R.A., Pereyra-Alférez B., Calderón-Garcidueñas A.L., Barrera-Saldaña H.A., Gallardo-Blanco H.L., Ortiz-López R., Flores-Peña Y., Cárdenas-Villarreal V.M., Rivas F., Figueroa A., Kshatriya G.; “Genetic structure of Mexican Mestizos with type 2 diabetes mellitus based on three STR loci”. Gene. 2013, Aug 1. 525(1):41-6. Cortés-Guzmán AJ, Sánchez-Casas RM, Ibarra-Juárez LA, Aldo I. Ortega-Morales, Julián E. Garcia-Rejón, Juan F. Contreras-Cordero, Pedro Mis-Ávila, Domínguez-Galera MA, Rebollar-Téllez EA, Medina-De la Garza CE, Fernández-Salas I. West Nile Virus Survey of Birds, Horses, and Mosquitoes of the Pacific Coast, Southern Mexico. Southwestern Entomologist. 2013; 38(2):231-240 Costilla-Esquivel A, Corona-Villavicencio F, Velasco-Castañón JG, Medina-De La Garza CE, Martínez-Villarreal RT, Cortes-Hernández DE, Ramírez-López LE, GonzálezFarías G.; “A Relationship between acute respiratory illnesses and weather”. Epidemiol Infect. 2013; 2:1-9. Deplanque D, Lavallee PC, Labreuche J, Gongora-Rivera F, Jaramillo A, Brenner D, Abboud H, Klein IF, Touboul PJ, Vicaut E, Amarenco P; Lacunar-BICHAT Investigators. “Cerebral and extracerebral vasoreactivity in symptomatic lacunar stroke patients: a case-control study”. Int J Stroke. 2013;8(6):413-21. Dohn A., Garza-Villarreal E.A., Chakravarty M.M., Hansen M., Lerch J., Vuust P., “Gray and white matter anatomy of absolute pitch possessors”. Cerebral Cortex. 2013. Escamilla-García E., Alcázar-Pizaña A.G., De La GarzaRamos M.A., Medina-De La Garza C.E., Márquez M. Antimicrobial of CatDex activity against Porphyromonas gingivalis-W83 and Streptococcus mutans-UA130. Journal of Dental Research (Special Issue). 2013; 3-4.

Gutiérrez-Gómez C, Godínez-Hana AL, García-Hernández M, Suárez-Roa MdeL, Toussaint-Caire S, Vega-Memije E, Gutiérrez-Mendoza D, Pérez-Dosal M, Medina-De la Garza CE. “Lack of IgG Antibody seropositivity to Borrelia burgdorferi in patients with Parry-Romberg Syndrome and Linear Morphea en coup de sabre in Mexico”. Int. J. Dermatol. 2013, (in press). Landeros-Olvera E, Benavides R, Frederickson K, Martínez-Reyes M. del C., Celis-García M; “Análisis del concepto “decisión de cambio” para mejorar las conductas de salud en el contexto de las enfermedades crónicas en adultos”. Aquichan. 2013; 13:57-68. Martinez-Fierro M.L., Garza-Veloz I., Rojas-Martinez A., Ortiz-Lopez R., Castruita-de la Rosa C., Ortiz-Castro Y., Lazalde-Ramos B.P., Cervantes-Villagrana A.R., GomezGuerra L., Martinez-Torres A.A.; “Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer”. Cancer Biomarkers. 2013. Martínez-Jacobo L, Córdova-Fletes C, Ortiz-López R, Rivas F, Saucedo-Carrasco C, Rojas-Martínez A. “Delineation of a de novo 7q21.3-q31.1 Deletion by CGH-SNP Arrays in a Girl with Multiple Congenital Anomalies Including Severe Glaucoma”. Molecular Syndromology. 2013; 4: 285-291. Medina-De la Garza CE, García-Hernández M, CastroCorona MA. Visual Mnemonics for serum protein electrophoresis. Med. Educ. Online. 2013. In process. Neira V.A., Romero-Espinoza P., Rojas-Martínez A., OrtizLópez R., Córdova-Fletes C., Plaja A., Barros-Núñez P.; “De novo MECP2 disomy in a Mexican male carrying a supernumerary marker chromosome and no typical Lubs syndrome features”. Gene. 2013. 524:381-385. Olvera-Blanco MA, Benavides-Torres RA, Cruz-Castruita RM, López-Rosales F, Onofre-Rodríguez DJ, MárquezVega MA; “Modelo de acompañamiento para la implementación efectiva de programas para prevenir el VIH/SIDA”. Evidentia. 2013; 10(41). http://www.index-f.com/evidentia/n41/ev7990.php

Ramirez-Jimenez R, Zarate-Nahon EA, Alvarado-Moreno MS, Sanchez-Casas RM, Laguna-Aguilar M, Sanchez-Rodriguez OS, Torres-Zapata R, Rivas-Estilla AM, RamosJimenez J, Medina-De la Garza CE, Villarreal-Perez JZ, Ibarra-Juarez LA, Dominguez-Galera MA, Mis-Avila P, Fernandez-Salas I. Potential dengue secondary infections associated to Aedes aegypti populations found in home environments in Monterrey, Mexico. Southwestern Entomologist. 2013; 38(1):99-108. Sánchez-Casas RM, Alpuche-Delgado RH, Blitvich BJ, Díaz-González EE, Ramírez-Jiménez R, Zarate-Nahon EA, Sánchez-Rodríguez OS, Laguna-Aguilar M, Marcela Alvarado-Moreno M, Ibarra-Juárez LA, Medina-de la Garza CE, Lorono-Pino MA, Marco Domínguez-Galera M, Mis-Ávila P, Fernández-Salas I. Detection of Dengue Virus Serotype 2 in Aedes aegypti in Quintana Roo, Mexico, 2011. Southwestern Entomologist. 2013; 38(1):109-117. Sánchez-García A, Ríos-Ibarra CP, Rincón-Sánchez AR, Ortiz-López R, Garza-Juárez A, Morlett-Chávez J, Martínez-Rodríguez H, Rivas-Estilla AM. Use of proteomic analysis tools to identify HCV-proteins down-regulated by acetylsalicylic acid. Annals of Hepatology. 2013; 12(5) 1-5. Torres-Capetillo E, Carrillo-Fuentevilla R, De la GarzaRamos MA, Mercado-Hernández R, Torre-Martínez H, Segoviano-Ramirez JC. “Antimicrobial efficacy of neutral super-oxidized electrolyzed gel versus chlorhexidine digluconate 0.12% in biofilm formation on orthodontic miniimplants: An in vitro study”. Journal of Pharmacognosy and Phytotherapy. 2013. 5, 64-71. Vera-Cabrera L., Ortiz-Lopez R., Elizondo-Gonzalez R., Ocampo-Candiani J.; “Complete genome sequence analysis of Nocardia Brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis”. PLoS One. 2013, Jun 3. 8(6):e65425. Zarate-Nahon EA, Ramirez-Jimenez R, Alvarado-Moreno MS, Sanchez-Casas RM, Laguna-Aguilar M, Sanchez-Rodriguez OS, Rivas-Estilla AM, Ramos-Jimenez J, MedinaDe la Garza CE, Villarreal-Perez JZ, Fernandez-Salas I. Aedes aegypti mosquitoes at non residential sites might be related to transmission of Dengue Virus in Monterrey, Northeastern Mexico. Southwestern Entomologist. 2013 (in press).

BOOKS & BOOKS CHAPTERS Medina-De la Garza CE, Castro-Corona MA. Inmunodeficiencias primarias y secundarias: características, diagnóstico y tratamiento inmunológico. En La inmunología en la Salud y la Enfermedad. México: Editorial Médica Panamericana, 2010: 165-181. Medina-De la Garza CE, Castro-Corona MA. Respuesta inmune contra infecciones por parásitos: factores del parásito y del hospedero involucrados en la respuesta a la infección. En La inmunología en la Salud y la Enfermedad. México: Editorial Médica Panamericana, 2011: 283-295.

Medina-De la Garza CE. Inmunodeficiencias primarias. En Fundamentos para el Ejercicio de la Medicina Guía para el Examen de Residencias Médicas ERM. México: Manual moderno, 2012: 285-291. Guzman, F., López, K., Alonso, M., & Benavides, R. Jóvenes de Pandillas en Monterrey: El Significado del Consumo de Drogas. En F. J. Uribe Salas y J. Parra Ávila. (Eds.), Salud Pública en la Frontera Norte de México. Tijuana, Baja California: Colegio de la Frontera Norte. 2012; 165-195. Picazzo-Palencia E. La salud y el desarrollo humano y sustentable. Alemania: Editorial Médica Española, 2012.

López, F. La conducta sexual responsable, y la auto eficacia percibida virtud o espejismo?. En J. C. Sánchez (Eds.), Tópicos de Psicología de la Salud en el Ámbito Universitario. México: CUMEX- UANL. 2011; 245-265.

Rojas-Martinez A. Anthropological and medical implications of genetic admixture in the Mexican mestizo population En Genomics and health in the developing world. United Kingdom: Oxford University Press, 2012: 1171-1258.0

Onofre, D, Cabello, M. Vulnerabilidad Social en Adolescentes con Síndrome Metabólico. Un problema Mundial de índole Social. En La Problemática de los grupos vulnerables: visiones de la realidad. [CD-ROM]. Facultad de Trabajo Social: Universidad Autónoma de Coahuila. 2011; 32-48.

Benavides R, Castillo L, Lopez F, Onofre D. Promoción de la Salud Sexual en Jóvenes. México, Distrito Federal: Manual Moderno. 2013.

Salinas-Carmona MC, Medina-De la Garza CE. Técnicas Inmnunológicas para el estudio de antígenos parasitarios. En Parasitología Médica. México: McGraw Hill, 2011: 345351.

Medina-De la Garza CE. (prologue). Publicaciones del Dr. José Eleuterio González en Ciencias Médicas. Sección Farmácia y Botánica Tomo II. Universidad Autónoma de Nuevo León. 2013

Chiú-García JA, Huerta-Pérez L, Cortés-Hernández DE, Velazco-Villavicencio V, Picazzo-Palencia E, Flores-Sepúlveda Y, Villarreal-Pérez JZ, Medina-De la Garza CE. Accidentes viales en Nuevo León Perfiles estadísticos 20042010. México: 2012 Esparza S, Benavides R, Moreno G, Alonso M, Paz M. Implicaciones de Greeca para el cuidado de enfermería, la docencia e investigación en el fenómeno e las drogas. En M. A. Alonso, K. López, N. Oliva, & F. Guzmán. (Eds.), Liderazgo en la prevención de uso y abuso de drogas: una experiencia. Monterrey, Nuevo León: Tendencias. 2012; 79-97. Godínez-Hana AL, Medina-De la Garza CE. Parasitosis. En Infectología Clínica. 2ª ed. México: Manual Moderno, 2012: 363-400. López F., Planeación innovadora para la intervención en Psicología. En M. García Meraz, R. Guzmán Saldaña, A. Romero Palencia, A. del Castillo Arreola, & G. Solano Solano, (Eds.), Evaluación e intervención en psicología: Planteamientos teóricos y empíricos. Hidalgo: Editorial del Estado de Hidalgo. 2012. Márquez, M., Benavides, R., Gallegos, E., Montoya, B., Núñez, G. Comunicación Sexual de Padres a Hijos: Teoría de la Acción Razonada y Conducta Planeada. En F. López y R. Benavides. (Eds.) Módelos Teóricos y Técnicas de Intervención en Salud. México, Distrito Federal: Trillas. (in press).

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Events & Seminars CIDICS is credited with first class facilities to support academic and science-related activities, such as conferences, symposia, workshops, etc. but facilities are just the place. Must important of all, are the scientist and students that share their knowledge and interact with their peers to create an academic and scientificminded environment. Here we list the seminars we had at CIDICS as a permanent effort to discuss our own work and to keep abreast of latest developments elsewhere. Also included are diverse academic endeavors that reflect the effort made throughout the first years.

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EVENTS 2011 February 21-24, 2011 “Proteomics Course: “Proteomics Study through Electrophoresis 2-d” February 25, 2011 “Bioethics Course” March 01, 2011 Conference: “Prevention and Diseases Control” March 04, 2011 Conference: “Superesolution Light Microscopy” March 08-09, 2011 “Workshop for the Development of Municipal Projects of Healthy Communities, 2011” March 25, 2011 “External Advisory Council Session of UANL” April 13, 2011 Signing of Agreement and Conference of the Federal Health Secretary: “Advances and Health Challenges” April 14-15, 2011 “Symposium: Food Safety, 2011” April 28-29, 2011 Course: “Vision and Action Opportunities for Minors and Family through Child Psychiatry and adolescence” May 26-27, 2011 “Methodology of Clinical Research in Psychiatry” June 14, 2011 Congress: “Blood Donor Global Day” July 04-06, 2011 “Course of Clinical Trials” Julio 21-22, 2011 “Thematic Network of CONACYT-Medicine and Health: Dengue” July 30, 2011 Course “Good Clinical Practices” August 08, 2011 “Crisis Intervention Diploma” August 26, 2011 “Context of Development, Postgraduate Quality National Program” September 05-06, 2011 Symposium: “BioMonterrey 2011” September 13, 2011 “Biocluster” September 16-17, 2011 Congress of Restorative Dentistry September 21, 2011 Symposium: “Animal Facility: Research and Policy” September 22, 2011 “Health Psychology Congress: Sleep Disorders” September 28 – October 01, 2011 “Regional Congress of Public Health Research” October 07, 08, 28 and 29, 2011 Course “Mathematical Epidemiology, Examples, Data and Associated Models” October 07-08, 2011 “Medical Symposium: News on Cancer” October 11, 2011 “Responding to the Challenge: Helps to Improve Mental Health”

October 13, 2011 “1st Qualitative Research Forum in Health Sciences” October 14-15, 2011 “1st National Congress of Psychotherapy” October 18, 2011 Conference: “Medical Image Segmentation: Practical Tools and Emerging Technologies” October 24-28, 2011 “Workshop Course in FISH, Course-Workshop” November 03, 2011 “Fostering and Innovation Support, Symposium” November 25, 2011 “Mexican Academy of Science, Conference” 2012 January 27, 2012 Mapping Program and Search of UANL Technology-Talents” January 28, 2012 “Updates on HIV” February 02, 2012 “Dialogue with Winners – IMSS” March 24, 2012 Session “The Skin in the Adult” March 26, 2012 “Tuberculosis Symposium” March 29, 2012 “Animal Management Course at Basic Level Laboratory“ April 17, 2012 “Forum of the Iberoamerican Network of Communication and Health” May 03, 2012 “Transforming Medical Science across the Americas through Biotechnology” May 09, 2012 “Physicians and the Creation of Theoretical Epidemiology” June 16, 2012 Workshop: Spatial Statistical Analysis and Systems of Geographic Information (SGI) with Applications on Public Health July 09-13, 2012 Certificate Course “Intervention on Crisis” July 17, 2012 “Good Clinical Practices” July 27-28, 2012 Conference: Current Statistics on Maternal Mortality in Nuevo Leon, Mexico. August 01, 2012 “Course-Workshop MAX-QDA” August 08-10, 2012 Symposium: “Food Safety, 2012” August 24, 2012 Conference: “Institutional Proposal for the Mexican Node Conformation of the Human Variome Project: DuchenneBecker Muscular Dystrophy as an Example” August 25, 2012 Conference: “Estrogenic Hormone Replacement and Cardiovascular Risk” August 27, 2012 Forum: “Seniors and Social Development”

August 28-29, 2012 “First National Meeting of Education for seniors” September 05-06 de 2012 “I Psychooncology Symposium” September 08, 2012 Course: “Good Clinical Practices” September 13-14, 2012 Congress: “Research in Public Health” September 17-21, 2012 Workshop: “Theoretical and Practical FISH Course and Microarrays” September 21, 2012 Symposium: “Tissue Regeneration with Stem Cells” September 25, 2012 Science in Motion – National Week of Science and Technology (CONACYT) September 26-27, 2012 Symposium: “Gambling Addiction” October 03, 2012 Conference: “The Genomic Landscape of Cancer and Aging” Dr. Carlos López Otin (Science and Technology Mexico Award, 2011) October 04-06, 2012 Course “Mathematical Epidemiology, Examples, Data and Associated Models” October 05-06, 2012 Symposium: “Obesity: Century Pandemic” October 16-19, 2012 Congenital Disorders Toolkit Workshop October 19-20, 2012 III National Congress “Psychoanalysis: Advances and Research in Mental Health” October 24-27, 2012 Course: “Carl Zeiss Microscopy” November 23-24, 2012 “International Course on Fetal Medicine” November 30, 2012 Symposium: “Animal Facility: Research and Policy” 2013 March 01-02, 2013 “Prioritary Program of Epilepsy, 2013” March 11, 2013 “Light Course – Sequencing” March 12-15, 2013 “Cell Cultivation Course” March 13, 2013 “Symposium: “Neuropsychiatry and Neurodegeneration” March 14-15, 2013 Symposium: “Validation of Process in Automation of the Sterilization Central and Equipments” April 12, 2013 “Mental Health and Woman Psychopathology” March 14-15, 2013 Symposium “Principal Pathologies and Clinical Approach of Seniors” May 22-24, 2013 Workshop: Technocal Cooperation and OPS/UANL Collaboration” May 25, 2013 Symposium: “Diabetes Type 2”

June 05-07, 2013 Course “Dental Pulp Stem Cells” June 7, 2013 Dual Disorders: Clinical and Therapeutic Aspects of Addictive Comorbidity June 8, 2013 Pacemaker Update Workshop June 14, 2013 Forum: Human Rights Commission June 21-22 2013 Symposium: “Neurology for non-neurologists” July 04, 2013 “Dialogue with Winners – IMSS” July 14, 2013 Symposium: “Pompe Disease Diagnosis” July 16-19, 2013 Training Workshop: Molecular tools for Diagnosis of Chlamydia: Morphological and Interpreting Clinical Correlation. July 26, 2013 Highlights in Allergies and Clinical Immunology August 7, 2013 Conference “Discovering the Helicobacter” by Dr. Robert Warren, Nobel Prize Medicine 2005 September 05-06, 2013 “II Psychooncology Symposium” SEMINARS 2011 26/01/2011 “Basal line about traffic accidents in Nuevo León, 2010” 02/02/2011 “Segmentation of Images from Special Samples and Investigation Advances in Medical Images” 09/02/2011 “Probabilistic Segmentation: Theory and Application” 16/02/2011 “Sensibility and Specificity on Investigation” 23/02/2011 “The Enigma of the Amyloses Fibers and its Relation with Neurodegenerative disease: The case of the Prion Protein” 02/03/2011 “Determination of antimicrobial compounds by lactic acid bacteria: Applications in oral health” 09/03/2011 “Quality and disorder of sleep in operators of the manufacturing industry. Data update” 16/03/2011 “ION-TORRENT PGM (Person Genome Machine) Technology Sequencing of New Generation” 23/03/2011 “Good Clinics Practices: Essential Documents” 06/04/2011 “Perspectives in the Investigation of Cancer” 12/04/2011 “Mathematics Modeling from the Incidence of Rate of Infectious Diseases in a population” 04/05/2011 “Dynamical Network Models in Biology”

11/05/2011 “Collective movement of animals and cells” 18/05/2011 “Free Software: Useful tools for Medical Investigation” 25/05/2011 “Multiple View, Multiple Target Tracking with Principal Axis-Based Data Association” 01/05/ 2011 “Health Regulation for Tobacco Control” 08/06/2011 “Pharmacokinetic - Statistical Models” 22/06/2011 “Guardians of Cell Cycle: Mitotic Checkpoints” 29/06/2011 “Inhibition of Biofilm of Bacteria from Oral Cavity” 03/08/2011 “Yellow Fever in Perú” 10/08/2011 “The images of heavy magnetic resonance on diffusion of hydrogen, and its processing form, estimate cerebral connections” 24/08/2011 “Hybrid Nanostructures with Potential Applications in Medicine” 31/08/2011 “Immobilized enzymes on polymeric nanofibers through the electrospinning technique and its application in biosensors and liberation systems of proteins” 14/09/2011 “Research Trend for Prevention of HIV/AIDS: Achievements and Challenges after 30 years” 05/10/2011 “Onchocerciasis: A Parasitosis Under Control in Mexico” 06/10/2011 “Mass Pyrosequencing” 12/10/2011 “Some Immunomodulatory Properties of Diethylcarbamazine” 18/10/2011 “Medical Image Segmentation Conference: Practical Tools and emerging technologies” 19/10/2011 “The Immune Innate Response: Background of the Nobel Prize 2011” 2012 11/01/2012 “Designing a Nanosystem for Activation and Guided Sending of Genes” 18/01/2012 “The Effect of Auditory Stimuli in Acute and Chronic Pain: Cognitive and Emotional Mechanisms and Placebo Effect” 24/01/2012 “Just do it! What Musical Practice Does to the Brain?” 01/02/2012 “Nanoparticles of Bismuth Inhibit the Growing and Formation of Biofilm of Streptococcus mutans” 08/02/2012 “Mechanism of Lipotixic Damage in obesity and its relevance in the development of diabetes type 2”

15/02/2012 “The Importance of Industrial Property” 22/02/2012 “Health Quality in the Trails of México” 29/02/2012 “Search of an Anti-Tuberculous new agent: New molecules with Potential vs Resistant Tuberculosis of Drugs” 07/03/2012 “Electronic Microscopy of the Viral Infections: Ultrastructural Aspects of the HIV Infection on lymphoid tissue. 14/03/2012 “Commercial Tendencies and Business Opportunities with China” 21/03/2012 “Treatment of Sewage” 18/04/2012 “Palmitoylation and Association of Synaptic Proteins with Lipid Rafts: Possible Implication on Plasticity in the Development of Addictions” 25/04/2012 “Experiences with the Adoption of Open Access Politics and the Institutional Repository” 09/05/2012 “Doctors and the Creation of the Theoretical Epidemiology 16/05/2012 “Evolution of a Vaccine: Paralityc Poliomyelitis Associated to Vaccination with Oral Sabin” 30/05/2012 “Through Mouth Enters the Enemy, Commensal Bacteria to produce health benefits” 06/06/2012 “Genetic Approaches for Cancer Treatment” 13/06/2012 “Regulation of COFEPRIS and Preparation of Requests for to obtain grants in USA” 20/06/2012 “Experimentation with Animal Models Applied to Investigation in Biomedicine. 27/06/2012 “The Economy of Health: Fundamental Aspects” 04/07/2012 “Use of Sexual Material Online and Sexual Risk Behaviors in Young College students” 01/08/2012 “Use of Mutant Mice as a Tool for Discovering New Features of Biomedical Importance in the genome” 15/08/2012 “Mexican Node of the Human Variome Project” 22/08/2012 “Issues of a warm Investigation” 28/08/2012 “International Seminary to Quality Certification on Medical Attention ans Security of the Patient” 19/09/2012 “Use of the Microarrays in Clinic and Investigation” 17/10/2012 “Public Health Genomics” 24/10/2012 “Presentation of the Online INEGI-Site” 31/10/2012 “Advances on Cerebral Ischemic Disease”

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21/11/2012 “Association Between the Diagnosed Curve of Glucose and Complications of Pregnancy in women with Gestational Diabetes” 28/11/2012 “Cellular Therapy: Effect of the Growing Factors and Differentiation in Cultivation of Chondrocytes for joint injuries repair” 05/12/2012 “Isolation and Cultivation of Mesenchymal Stem-Cells from Human Dental Pulp” 12/12/2012 “Xerostomia and Sjogren Syndrome” 19/12/2012 “Tobacco selected toxicological and toxicogenomic analysis in a group of young volunteers” 2013 23/01/2013 “Effect of Climate Change in Vector Borne Diseases” 06/02/2013 “Human Variome Project” 13/02/2013 “Adjuvant Effect Analysis of Calreticulin on Immunogenicity of Antigens ag85b, esat-5, cfp-10 and the Protection against damage caused by Mycobacterium tuberculosis” 20/02/2013 “To clean is something more than the use of a chemical disinfectant” 27/02/2013 “Obesity and Cardiac Abnormalities: What was first, Egg or Chicken?” 06/03/2013 “Microbial Activity of CatDex Against Porhyromonas gingivalis Bacteria and Steptococcus mutans, both present in Oral Diseases” 13/03/2013 “Computational Neuroanatomy in Neuropsychiatric Disorders” 20/03/2013 “The RNAi as a Therapeutic Tool Against Cancer” 10/04/2013 “Neuropsychology of Aging” 11/04/2013 “Investigation on Genetically Modified Mice” 17/04/2013 “Morphogenesis and Organogenesis in Drosophila: From Synthetic Gene Regulation to Its Application on Pathological Processes” 08/05/2013 “Biological Markers of Neuropsychiatric Symptoms in Alzheimer’s disease” 22/05/2013 “Parkinson’s Disease” 25/05/2013 “2013 Seminary Diabetes Type 2” 29/05/2013 “Study of the Specific Antigen Asthmatic Reactivation Produced by Inflammatory Stimuli in a Murine Model”

05/06/2013 “Participation of Glutamate Receptors and Palmitoylation of Proteins in the development of addictions” 19/06/2013 “The Approach of Violence through Research on Public Health” 03/07/2013 “The Role of Mast Cells in Ultraviolet-induced immunosuppression” 21/08/2013 “Intelligent Planning, lessons learned in E-Learning for EHealth” 04/09/2013 “Memory’s Molecular Mechanisms: Implications in a transgenic model of Alzheimer’s disease”

Staff

Director Carlos E. Medina-De la Garza P. +52(81) 1340 4370 ext. 1705 carlos.medina@uanl.mx

Emerging Pathogens and Vectors Ildefonso Fernández-Salas P. +52(81) 1340 4370 ext. 1789 ildefonso.fernandezsl@uanl.edu.mx

Administrative Coordinator Felipe E. Garza-García P. +52(81) 1340 4370 ext. 1729 felipe.garza@uanl.mx

Public Health Research Dora Elia Cortés-Hernández Tel. +52(81) 1340 4370 ext. 1753 dora.cortesh@uanl.mx

Academic Coordinator Dora Elia Cortés-Hernández Tel. +52(81) 1340 4370 ext. 1753 dora.cortesh@uanl.mx

Health Psychology Arnoldo Téllez-López P. +52(81) 1340 4370 ext. 1768 arnoldo.tellez@uanl.mx

Public Relations Daniela Azpilcueta-Salinas P. +52(81) 1340 4370 ext. 1723 daniela.azpilcuetas@uanl.mx

Neuroscience Héctor J. Villarreal-Velázquez Eduardo Garza-Villarreal P. +52(81) 1340 4370 ext. 1757 eduardo.garzav@uanl.mx

Biosafety Office Efraín Montes-Villarreal P. +52(81) 1340 4370 ext. 1740 efrain.montesv@uanl.mx Research Units Gene and Cell Therapy Augusto Rojas-Martínez P. +52(81) 1340 4370 ext. 1751 augusto.rojasm@uanl.mx Influenza and Respiratory Pathogens Gerardo Velazco-Castañón P. +52(81) 1340 4370 ext. 1761 jose.velascoc@uanl.mx

Immunomodulators Carlos E. Medina-De la Garza P. +52(81) 1340 4370 ext. 1705 carlos.medina@uanl.mx Health Education Nursing Raquel A. Benavides-Torres P. +52(81) 1340 4370 ext. 1764 raquel.benavidest@uanl.mx Integral Dentistry Myriam A. De la Garza-Ramos P. +52(81) 1340 4370 ext. 1781 myriam.garzam@uanl.edu.mx Bioethics Eloy Cárdenas-Estrada P. +52(81) 1340 4370 ext. 1743 eloy.cardenases@uanl.edu.mx

Bio-Modelling Mario A. Guzmán-García P. +52(81) 1340 4370 ext. 1828 Víctor Daniel L. Garzón-Cortés P. +52(81) 1340 4370 ext. 1830 victor.garzoncr@uanl.edu.mx Bioimaging Juan Carlos Segoviano-Ramírez P. +52(81) 1340 4370 ext. 1766 juan.segovianor@uanl.mx Molecular Biology, Genomics and Sequencing Rocío Ortiz-López P. +52(81) 1340 4370 ext. 1750 rocio.ortizl@uanl.mx Knowledge Management Juan Manuel Saldívar-Blanco P. +52(81) 1340 4370 ext. 1745 juan.saldivar@dgb.uanl.mx Vaccinology / Clinical Research Eloy Cárdenas-Estrada P. +52(81) 1340 4370 ext. 1743 eloy.cardenases@uanl.edu.mx Tissue Engineering Fernando Pérez-Chávez fernando.perezch@uanl.mx P. +52(81) 1340 4370 ext. CIMAT Monterrey (CONACYT) Graciela González-Farías P. +52(81) 1340 4370 ext. 1778 farias@cimat.mx

Staff, associated researchers and collaborators of CIDICS Abiel H. Mascareñas-De los Santos Adriana Sánchez-García Alan Roberto Vázquez-Alcocer Alberto Camacho-Morales Alejandro Durán-De la Re Alicia Yudith Costilla-Gómez Allyson Treviño-García Ana Lorena Godinez-Hana Ana María Rivas-Estilla Anders R. Holmberg Andrea G. Alcázar-Pizaña Andrés Carreón-Lozano Antonio Costilla-Esquivel Carlos Alberto Hernández-Puente Carlos Córdova-Fletes Carol Elizabeth de León-Orozco Casiano Del Ángel-Mosqueda Cecilia V. Martínez-Hernández César E. Cabral-Heredia Cruz del Carmen Esquivel-Carrillo David Alejandro Galván-García Dehisy Marisol Juárez-García Deyanira Núñez-Torres Dora Julia Onofre-Rodríguez Edgar Jiménez-Peña Edith Flores-Ceballos Eduardo Álvaro-Galue Erandi Escanilla-García Esteban Picazzo-Palencia Fátima Miroslava Alvarado-Monroy Francisco Hernández-Cabrera Fuensanta López-Rosales Gissela Borrego-Soto Grecia Iris Uscanga-Perales Griselda Garza-González Guadalupe A. Pedraza-Grimaldo Guillermo Flores-Briseño Gustavo Leal-Isla-Sánchez Héctor E. Hernández-González Héctor Fernando Galván-García

Héctor Peralta-Santoyo Héctor Xavier Martínez-Sánchez Humberto A. Salazar-Sesatty Ilse Delint-Ramírez Isaías Cruz-Jiménez Iván Alberto Marino-Martínez Iván Hernández-Romero Janet García-González Janete Sotelo-Rubio Javier Ramos-Jiménez Jesús Daniel Quiñones-García Jorge Alberto Chiu-García Jorge Humberto Hernández-Morales Jorge Villarreal-González José Alfredo Romo-Dávila José Arcadio Valdés-Franco José de Jesús Herrera-de la Rosa José María Buenrostro-Franco José Ramón Domínguez-Molina Josefina De la Riva-González Juan Eugenio Elizondo-Martínez Juan Fernando Góngora-Rivera Juan Roberto Zavala-Treviño Juanita González-Domínguez Julio César Rodríguez-López Laura E. Ramírez-López Laura H. De la Garza-Salinas Laura Rivera-Narváez Leticia A. Zavala-Gómez Leticia Jaime-Bernal Letycia A. Zavala-Gómez Lourdes Huerta-Pérez Lucinda Sepúlveda-García Luis Eugenio Todd-Pérez Luis Guillermo Segura-Herrera Lubia del Carmen Castillo-Arcos Marcela Granados-Shiroma Marcela Márquez-Holmberg María Aracely Márquez-Vega María de los Ángeles Castro-Corona

María Elena de la Cruz-Maldonado María Teresa Salas-Cantú Mario Alberto Maldonado-Ramírez Marisela García-Hernández Martha García-Durán Martha Patricia Monsiváis-García Mary Carmen Saucedo-Zúñiga Mayra Hernández-Mendoza Miguel Ángel Gutiérrez-Barrón Miguel Soto-Valdez Nora Dalia Cabrera-Rivera Norma Guadalupe López-Cabrera Omar Martin Ledesma-Guadarrama Oscar Álvarez-Hernández Oscar Santiago-Sánchez Oscar Susano Dalmau-Cedeño Patricia Ancer-Rodríguez Patricia Villarreal-Quiroga Pavel Antonio Hipólito-López Perla Lizbeth Pérez-Ledezma Porfirio Tamez-Solís Ramiro Elizondo-González Ramsés Medina-González Rebeca Thelma Martínez-Villarreal Roberta Garza-Tamez Roberto Cantú-Lazo Rodrigo Macías-Páez Rodrigo Soto-Moreno Rosa María Sánchez-Casas Rosalinda Rivera-Ríos Salvador Pinales-Armendáriz Sandra Santuario-Facio Santos Adriana Sánchez-Rodríguez Sergio Maltos-Uro Tomás Nangullasmú-Plasencia Verónica Velasco-Villavicencio Víctor A. Tamez-Rodríguez Víctor Hugo Muñiz-Sánchez Yesenia Marina Flores-Sepúlveda Zaira Lucía González-Contreras 179

Gallery

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Art in CIDICS The 15,500 square meters of the Center are not only laboratories, meeting rooms and research oriented rooms. CIDICS was conceived also as a place where esthetics should be in alignment with the human activities performed here. A number of distinguished artists have made with their work, a bright and beautiful place of CIDICS, a place to explored, to investigate, to question and to answer, all this in a friendly environment. Here youâ&#x20AC;&#x2122;ll see some of the arts displayed here.

Clemencia, acrylic on canvas. Author: Antonio Pruneda. 2009. Size: 100 x 150 cm. Location: Foyer, CIDICS - UANL

Asombro de la Humanidad, mix on canvas. Author: Sergio Villarreal. 2009. Size: 118 x 168 cm. Location: Direction, CIDICS - UANL

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Renacer 1, oil on canvas. Author: Cora Diaz. 2010. Size: 500 x 120 cm. Location: Foyer south wall, CIDICS - UANL

Renacer 2, oil on canvas. Author: Cora Diaz. 2010. Size: 500 x 120 cm. Location: Foyer south wall, CIDICS - UANL

Renacer 3, oil on round canvas. Author: Cora Diaz. 2010. Size: 240 x 820 cm. Location: Foyer of Auditorium, main floor, CIDICS - UANL

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Desnudo, acrylic on linen. Author: Armando Lopez. 2003. Size: 125 x 130 cm. Location: Foyer, CIDICS - UANL

La monta単a siempre nuestra, mixed on canvas. Author: Gerardo Canttu. 1977. Size: 500 x 400 cm. Location: Foyer, Auditorium north wall, CIDICS - UANL

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Origenes (de la serie paisaje), oil on canvas. Author: Cora Diaz. 2009. Size: 150 x 100 cm. Location: 1st floor, CIDICS - UANL

Virus del Nilo Oeste, acrylic and charcoal on canvas. Author: Esteban Ramos. 2009. Size: 100 x 150 cm. Location: Foyer of Auditorium, main floor, CIDICS - UANL

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Imprint

Photographs and illustrations were provided by authors or CIDICS/UANL-staff and they respond to copyrights. Other photos were obtained from different sources in compliance to educational uses and non-profit purposes. No infringement of any copyright was intended in this publication and photos for illustrating purposes were obtained, to our best knowledge from copyright free sources.

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CIDICS: Science for our Society, Carlos Eduardo Medina-De la Garza and Dora Elia Cortés-Hernández was printed in November 2013 by Serna Impresos S.A. All body copy was set in Minion Pro 10-19 pt. and headlines were MyriadPro 70 pt. Copy editing and proofreading by the authors and Daniela Azpilcueta-Salinas and José Gerardo Velasco-Castañón. Cover was designed by Claudio Tamez-Garza.