Computer aided pattern recognition of oral pre cancerous lesions principal investigators professor c

Page 4

IV. CONCLUSION We have presented development steps toward a computer aided analysis and diagnosis system for oral mucosal lesions. Two common classifiers were evaluated on real data obtained from the lesion of the oral cavity. The obtained overall classification accuracy around 85% may be compared with the human performance. The diagnostic performance of the human specialist is estimated at 90%, while the diagnostic ability of dentists in general practice is estimated at 75%, when compared to a specialist [5]. Our current oral lesion database includes additional image samples from Indian population, such as erytroplakia and oral submucous fibrosis, which have high chances to develop into oral cancer. The lesions will be analysed as the number of cases will grow. The larger number of examples will give more accurate estimates of the classification performance. The advantage of standard color imaging is its simplicity and the low cost. The technique is also non-invasive, and sensitive for screening and early detection. Such technology will help the countries in South-East Asian region loaded with the highest number of oral cancer in the world [3]. It also will help in other parts of the world. However, due to the overlapping between the investigated classes, to improve the systems performance, probably we may need to incorporate additional imaging data from frequencies beyond the visual spectrum of the light. The developed method will be implemented as a lesion analysis tool and decision support system, and that could be used in India and other clinical settings elsewhere.

R EFERENCES [1] W. Barrett and E. Mortensen, Interactive live-wire boundary extraction, Medical Image Analysis 1(4), pp. 331-341, 1997 [2] C. Cortes, V. N. Vapnik, ”Support vector networks”, Machine Learning 20 (1995) 273-297 [3] P. C. Gupta and A. Nandakumar, Oral cancer scene in India, Oral Diseases, 1999, No 1: 1-2. [4] R. Herbrich, T. Graepel and C. Campbell, ”Bayes point machines”, J. Mach. Learn. Res. 1, pp.245-279, 2001 [5] J. A. Jullien, M. C. Downer, J. M. Zakrzewska and P. M. Speight, ”Evaluation of the screening test for the early detection of oral cancer and precancer”, Community Dent Health 12, pp.3-7, 1995 [6] U. Mattsson, A. Chodorowski, T. Gustavsson, M. Jontell, F. Bergqvist, ”Use of computer-assisted image analysis for noninvasive evaluation of oral lichenoid reactions and oral leukoplakia.” Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb;79(2):199-206 [7] T. P. Minka, A family of algorithms for approximate Bayesian interference. Doctoral dissertation, Massachusetts Institute of Technology, 2001 [8] M. Opper and O. Winther, Gaussian processes for classification: Mean field algorithms. Neural Computation 12, pp. 2655-2684, 2000 [9] J. Reibel, Prognosis of oral pre-malignant lesions: Significance of clinical, histopathological and molecular characteristics. Crit Rev Oral Bio Med 14(1) (2003) 47-62 [10] P. Rujan, ”Playing billiard in version space”, Neural Computation, vol. 9, no. 1, pp.99-122, 1997 [11] V. N. Vapnik, ”The Nature of Statistical Learning Theory”, 1st ed., Springer-Verlag, New York (1995) [12] K. Veropoulos, C. Campbell and N. Cristianini. ”Controlling the Sensitivity of Support Vector Machines.”, In Proceedings of the International Joint Conference on Artificial Intelligence (IJCAI99), Workshop ML3, pp. 55-60. Stockholm, Sweden, 1999 [13] J. Weston, S. Mukherjee, O. Chapelle, M. Pontil, T. Poggio and V. Vapnik ”Feature selection for SVMs”, in Advances in Neural Information Processing Systems, Vol, 13, 2000 [14] N. Yamamoto, T. Kuroiwa, A. Kutakura, T. Shibahara and C. Choudhury ”Loss of Heterozygosity (LOH) on Chromosomes 2q, 3p and 21q in Indian Oral Squamous Cell Carcinoma”, Bull. Tokyo Dent Coll, 48(3):109-117, 2007


Issuu converts static files into: digital portfolios, online yearbooks, online catalogs, digital photo albums and more. Sign up and create your flipbook.