MEDICINE Insertion
LC09 aptamer PEG-PEI-Cholesterol (PPC) 10% Lactose
Incubation
Incubation
CRISPR/Cas9 plasmids Credit: HKBU
PPC-CRISPR/Cas9
THE GOODS CANCER
LC09-PPC-CRISPR/Cas9
CRISPR/Cas9 gene editing compounds are mixed with a lipid polymer solution (PPC) (left), which leads to CRISPR/Cas 9 being spontaneously encapsulated by a protective lipid layer (center). Then molecules designed to specifically recognize osteosarcoma cells, called LC09 aptamers, are added to the exterior of the lipid layer (right). This enables the CRISPR/Cas9 compounds to specifically target and edit a gene controlling blood vessel formation in osteosarcoma cells, thereby limiting tumour growth.
ASIA RESEA RC H N EWS 201 9 Credit: (Composite) Rajesh Rajendran Nair & ktsdesign | 123rf
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